OHKUBO Iwao 大久保岩男

Researcher Number	80152073
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2011: 天使大学, 看護栄養学部, 教授 2003 – 2008: 滋賀医科大学, 医学部, 教授 1993 – 1996: 滋賀医科大学, 医学部, 教授 1991 – 1993: 滋賀医科大学, 教授 1990 – 1991: 滋賀医科大学, 医学部, 教授 1987 – 1989: 名古屋市立大学, 医学部, 助教授
Review Section/Research Field	Principal Investigator General medical chemistry / Pathological medical chemistry / Pathological medical chemistry Except Principal Investigator Pathological medical chemistry / Orthopaedic surgery / Legal medicine / Legal medicine
Keywords	Principal Investigator キニノーゲン / kininogens / Mutagenesis / キニノ-ゲン / ミュタジェネシス / thiol proteinases / Complex / ELISA / モノクロナール抗体 / カルパイン … More / チオ-ルプロティナ-ゼ / チオ-ルプロテイナ-ゼ / 複合体 / Prokaryotic cells / Eukaryotic cells / Bacuro virus / Kininogens / Functional domains / 発現 / 重鎖 / PCR / 昆虫細胞 / プライマー / Site-directed mutagenesis / バキュロウイルス / reactive site / cysteine protease inhibitor / 反応部位 / システインプロテア-ゼ / His-Gly-Lysモチーフ / ヒト高分子キニノーゲン・ドメイン5 / αアクチニン4 / 阻害ペプチド / マトリゲル浸潤阻害 / 血管新生阻害 / アポトーシス / ペプチド / 管形成阻害 / 高分子キニノーゲン / 分子腫瘍学 … More Except Principal Investigator AAP / インヒビター / プロテアーゼ / Chemotactic factor / Calpain / Inflammation / 免疫グロブリン / ロイコエグレッシン / アセチル化ペプチド / 走化性因子 / カルパイン / 炎症 / inhibitor(s) / intrinsic opioid / cerebrospinal fluid / spinal pain remission system / Dipeptidyl peptidase III / 内因性オピオイド / 脳脊髄液 / 脊髄性疼痛抑制系 / ジペプチジールペプチダーゼIII / Brain Disorder / Glycoconjugate / CSF / Protease and Protease Inhibitor / ドーパミンニューロン / アルツハイマー型痴呆 / 統合失調症 / 免疫組織化学染色 / レクチン染色 / SIDS / オリーブ・橋・小脳路 / 脳幹網様体 / 法医病理学 / 脳虚血 / 睡眠・窒息 / βトレイス / プロスタグランヂンD2合成 / システチンC / プロスタグランヂンD2 / シスタチンC / CoX2 / 死後脳診断 / 法医病理診断 / HASSALL'S CORPUSCLES / SPERMATOGENESIS / TASTE BUDS CELLS / TRANSFERAZE GENES / ABO BLOOD GROUP / 人獣鑑別 / ABO遺伝子 / 糖鎖転移酵素遺伝子 / 味蕾細胞 / ABO式血液型抗原 / 精子成熟 / ハッサル氏小体 / ABO式血液型遺伝子型 / amino acid sequence / Infectious disease / human liver / DDP II / アミノ酸配列 / 感染種 / ヒト肝臓 / DDPII / Antigen presentation / Intracellular protease transport / Amyloidogenic protease / Calpain activation due to inafarotion / Hematocyte coagulation factor / Thrombomodulin / 94K calpain / Limited proteolysis / ニュ-カッスル病ウイルス / 26Sプロテアソ-ム / T細胞エイズレセプタ- / カルパインペプチドの白血球遊走活性 / カルパインの活性化 / プレプロタキキニン遺伝子発現調節因子 / プロテア-ゼによる情報発現 / トランスゴルジ膜結合性プロセシングプロテアーゼ / カテプシンBの抗原阻囎への関与 / 心筋梗塞巣活性化カルパイン / プロガストリンの活性化 / 筋組織特異的カルパイン / カテプシン-インバリアント鎖による抗原提示の調節 / 筋組織特異的94Kカルバイン / カテプシンの抗原提示への関与 / カテプシンの細胞内選別輸送 / アミロイドジェニックプロテアーゼ / 脳梗塞巣活性化カルパイン / 血球内凝固因子 / スロンボモジュリンの発現調節 / 筋組織特異的94Kカルパイン / プロテアーゼによる情報発現 / Geranylgeranylzation / Processing / Amidation / Cystine protease / Glycation / システィンプロテア-ゼ / ゲラニルゲラニル化 / プロセシング / アミド化 / システィンプロテアーゼ / 糖化 / 肥満 / メタボリック症候群 / 靭帯 / メタボリック症候 / 脂質代謝 / 変性肥厚 / 靱帯 / プロテオーム解析 Less

Proteomic analysis for the degenerative changes of yellow ligament
- Principal Investigator
  
  OGIKUBO Osamu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagoya City University
A study of high weight molecular kininogen domain 5 derived peptide : Inhibition of metastasis and vascularization, and induction of apoptosisPrincipal Investigator
- Principal Investigator
  
  OHKUBO Iwao
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Shiga University of Medical Science
Interaction of dypeptidyl peptidase III and its inhibitors, which has an important role in spinal pain remission system
- Principal Investigator
  
  FUKUOKA Muneyoshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  NAGOYA CITY UNIVERSITY
Some enzymes in the cerebrospinal fluid and glyco-conjugates may be useful to diagnose brain disorder
- Principal Investigator
  
  NISHI Katsuji
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Legal medicine
- Research Institution
  Shiga University of Medical Science
Infectious disease, and hepatic and gastrointestinal disease in Japan and China
- Principal Investigator
  
  OKADA Yoshio
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Shiga University of Medical Science
THE FORENSIC APPLICATION OF ABO BLOOD GROUP GENES AND BIOLOGICAL SIGNIFICANCE OF THE ANTIGENS
- Principal Investigator
  
  NISHI Katsuji
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  SHIGA UNIVERSITY OF MEDICAL SCIENCE
Analysis of the funcional domains of the heavy chain of kininogens by using the technique of site directed mutagenesisPrincipal Investigator
- Principal Investigator
  
  OHKUBO Iwao
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Shiga University of Medical Science
The post-translational modification of proteins
- Principal Investigator
  
  TANIGUCHI Naoyuki
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka University
Roles of proteases in signal transduction and their disorders
- Principal Investigator
  
  SASAKI Makoto
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagoys City Unversity Medcal School
Determination of the reactive site (s) of kininogens for cysteine proteases using technique of site-directed mutagenesisPrincipal Investigator
- Principal Investigator
  
  OHKUBO Iwao
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Shiga university of Medical Science
Pathological and biochemical significance of the complex between kininogens and thiol proteinasesPrincipal Investigator
- Principal Investigator
  
  OHKUBO Iwao
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagoya City University
Roles of thiol proteases and kininogens in induction and regulation of inflammation
- Principal Investigator
  
  SASAKI Makoto
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagoya City University Medical School

All 2010 2009 2008 2007 2006 2004 Other

All Journal Article Presentation

[Journal Article] Shedding of gACE from residual body membrane of rat sperm2009
- Author(s)
  Takeuchi K, Sakaue T, Yamamoto Y, Nishi K, Ohkubo I
- Journal Title
  
  Leg. Med.(Tokyo) 11
- NAID
  10027263023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590304
[Journal Article] Immuno-histochemical characteristics of necrotic area in the old-infarction area of human brain bu using of antibodies against cystatin c cathepsin B, puromycin sensitive alanyl-aminopeptidase and prostaglandin D2 synthase - A preliminary oxamination.2007
- Author(s)
  A.Kobayashi, I.Takase, T.Kitamura, A.Takamure, M.Ohyagi, A.Morimoto, S.Yamasaki, Y.Yamamoto, I.Ohkubo, K.Nishi, Anil Aggrawa
- Journal Title
  
  Internet Journal of Forensic Medicine and Toxicology 8(In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390212
[Journal Article] Legumain/asparaginyl endopeptidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal proximaltubular cells2007
- Author(s)
  Morita Y, Araki H, Sugimoto T, TakeuchiK, Yamane T, Maeda T, Yamamoto Y, NishiK, Asano M, Shirahama-Noda K, NishimuraM, Uzu T, Hara-Nishimura I, Koya D,Kashiwagi A, Ohkubo I
- Journal Title
  
  FEBS Lett 581
  
  Pages: 1417-1424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590304
[Journal Article] Porcine germinal angiotensin I-converting enzyme : Isolation andcharacterization and molecular cloning2007
- Author(s)
  Takeuchi K, Araki H, Sakaue T, Yamamoto Y, Fujiwara M, Nishi K, Ohkubo I
- Journal Title
  
  Comp. Biochem. Physiol. part B 146
  
  Pages: 215-226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590304
[Journal Article] Immuno-histochemical characteristics of necrotic area in the old-infarction area of human brain bu using of antibodies against cystatin c cathepsin B, puromycin sensitive alanyl-aminopeptidase and prostaglandin D2 synthase - A preliminary examination.2007
- Author(s)
  A.Kobayashi, I.Takase, T.Kitamura, A.Takamure, M.Ohyagi, A.Morimoto, S.Yamasaki, Y.Yamamoto, I.Ohkubo, K.Nishi, Anil Aggrawa
- Journal Title
  
  Internet Journal of Forensic Medicine and Toxicology 8(In press)
- Data Source
  KAKENHI-PROJECT-15390212
[Journal Article] Proximal HNF1 element is essential for the induction of human UDP-glucurosyltransferase 1A1 by glucocorticoid receptor.2006
- Author(s)
  Usui T, Kuno T, Ueyama H, Ohkubo I, Mizutani T.
- Journal Title
  
  Biohem.Phamacol. 28
  
  Pages: 693-701
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591503
[Journal Article] Co-expression of COX-2 and L-PGDS in Brain2006
- Author(s)
  A.Kobayashi, I.Takase, A.Takamure, Y.Yamamoto, I.Ohkubo, K.Nishi
- Journal Title
  
  Proceeding of IALM, MedimondS.R.I. G823C0221(Web)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390212
[Journal Article] Legumain/asparaginyl endopeptidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal proximal tubular cells.2006
- Author(s)
  Y.Morita, H.Araki, T.Sugimoto, K.Takeuchi, T.Yamane, T.Maeda, Y.Yamamoto, K.Nishi, M.Asano, K.Noda, M.Nishimura, T.Uzu, I.Nishimura, D.Koya, A.Kashiwagi, I.Ohkubo
- Journal Title
  
  FEBS Letters 8
  
  Pages: 1417-1424
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390212
[Journal Article] Legumain/asparaginyl endopeptidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal proximal tubular cells.2006
- Author(s)
  Y.Morita, H.Araki, T.Sugimoto, K.Takeuchi, T.Yamane, T.Maeda, Y.Yamamoto, K.Nishi, M.Asano, K.Noda, M.Nishimura, T.Uzu, I.Nishimura, D.Koya, A.Kashiwagi, I.Ohkubo
- Journal Title
  
  FEBS Letters 581
  
  Pages: 1417-1424
- Data Source
  KAKENHI-PROJECT-15390212
[Journal Article] Co-expression of COX-2 and L-PGDS in Brain2006
- Author(s)
  A.Kobayashi, I.Takase, A.Takamure, Y.Yamamoto, I.Ohkubo, K.Nishi
- Journal Title
  
  Proceeding of IALM, MedimondS.R.l. (G823C0221)(web)
- Data Source
  KAKENHI-PROJECT-15390212
[Journal Article] Primary structure and properties of Mn-superoxide dismutase(Mn-SOD)from scallop adductor muscle.2006
- Author(s)
  Ikebuchi M, Takeuchi K, Yamane T, Ogikubo O, Maeda T, Kimura H, Ohkubo I.
- Journal Title
  
  Int.J.Biochem. & Cell Biol. 38
  
  Pages: 521-532
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591503
[Journal Article] Stimulation of transcriptional expression of human UDP-glucuronosyltransferase 1A1 by dexamethasone.2004
- Author(s)
  Kanou M, Usui T, Ueyama H, Sato H, Ohkubo I, Mizutani T.
- Journal Title
  
  Mol.Biol.Report 31
  
  Pages: 151-158
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591503
[Journal Article] Identification of antigenic epitopes recognized by Mac-2 binding protein-specific cytotoxic T lymphocytes for use in cancer immunotherapy.2004
- Author(s)
  Ozaki Y, Kontani K, Teramoto K, Fujita T, Tezuka N, Sawai S, Watanabe H, Fujino S, Asai T, Ohkubo I.
- Journal Title
  
  Biochem.Biophys.Res.Commn. 317
  
  Pages: 1089-1095
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591503
[Journal Article] Functional role of hCNGB3 in regulation of human cone CNG channel : Effect of rod monochromacy-associated mutations in hCNGB3 on channel function.
- Author(s)
  Okada A, Ueyama H, Toyoda F, Oda S, Ding W-G, Tanabe S, Yamade S, Matsuura H, Ohkubo I, Kani K.
- Journal Title
  
  Invest.Ophthalmol.Vis.Sci. 45
  
  Pages: 2324-2332
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591503
[Presentation] 血漿Zn-α2-glycoprotein測定値と肥満との相関について2010
- Author(s)
  竹内圭介、林良美、荻久保修、大塚隆信、大久保岩男
- Organizer
  第83回日本生化学学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21591902
[Presentation] Identification of actinin-4 as a binding protein for domain 5 of high molecular weight kininogen on MG-632008
- Author(s)
  Tunetoshi Hato, Toshinaga Maeda, Susumu Uchiyama, Daisuke Nou, Keisuke Takeuchi,Osamu Ogikubo, Iwao Ohkubo and Takanobu Otsuka
- Organizer
  The 23^<rd> Annual Research Meeting of theJapanese Orthopaedic Association
- Place of Presentation
  国立京都国際会館
- Year and Date
  2008-10-24
- Data Source
  KAKENHI-PROJECT-19590304
[Presentation] ヒトキニノーゲンdomain 5由来ペプチドによるMG-63細胞における遺伝子発現変化2007
- Author(s)
  山根拓也, 渡辺一史, 杉本直之, 蜂須麗, 竹内圭介, 前田利長, 大久保岩男
- Organizer
  BMB2007
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19590304

1. TAKEUCHI Keisuke (40432306)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
2. KATUNUMA Nobuhiko (50035375)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. SASAKI Makoto (10080003)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. NISHI Katsuji (60073681)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
5. YAMAMOTO Yoshio (60111902)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
6. UEYAMA Hisao (30127013)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MAEDA Toshinaga (20250342)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. OGIKUBO Osamu (00291584)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. HAYASHI Yoshimi (80444967)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. ISHIGURO Hiroshi (20211039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TANIGUCHI Naoyuki (90002188)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SHIMOMURA Yasutugu (00029951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. OOMURA Tsuneo (80029933)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TASHIRO Yutaka (40077558)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MAKITA Akira (60004561)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. IWANAGA Sadaaki (90029942)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. SUZUKI Koichi (80011948)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. OKADA Yoshio (10106825)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. YAMAMOTO Gaku (40230544)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. YOSHITAKE Kazusada (80108985)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. TAKAGAKI Masaru (10171414)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. YAMADA Mitsuko (80145911)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. TAKATSU Akihiro (60010089)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. IKEMOTO Keiko (90184449)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. TAKASE Izumi (30351406)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
26. FUKUOKA Muneyoshi (80285204)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. KUNIMATSU Mitoshi (70145746)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 高橋健治 (70011533)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 木南英紀 (10035496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 市原明 (40035374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 賀佐伸省 (10142712)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 種子島章男 (70283520)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 牛山郁子 (70283562)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 高永波

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 杜培革

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. GAO Yongbo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. DU Peige

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OHKUBO Iwao 大久保 岩男

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study of high weight molecular kininogen domain 5 derived peptide : Inhibition of metastasis and vascularization, and induction of apoptosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the funcional domains of the heavy chain of kininogens by using the technique of site directed mutagenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Determination of the reactive site (s) of kininogens for cysteine proteases using technique of site-directed mutagenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathological and biochemical significance of the complex between kininogens and thiol proteinasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Shedding of gACE from residual body membrane of rat sperm2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Immuno-histochemical characteristics of necrotic area in the old-infarction area of human brain bu using of antibodies against cystatin c cathepsin B, puromycin sensitive alanyl-aminopeptidase and prostaglandin D2 synthase - A preliminary oxamination.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Legumain/asparaginyl endopeptidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal proximaltubular cells2007

Author(s)

Journal Title

OHKUBO Iwao 大久保岩男