IKEDA Hitoshi 池田均

Researcher Number	80202422
Other IDs
Affiliation (based on the past Project Information) *help	2015 – 2018: 東京大学, 医学部附属病院, 准教授 2007 – 2013: 東京大学, 医学部附属病院, 准教授 2007 – 2008: The University of Tokyo, Faculty of Medicme, Associate Professor 2007: 東京大学, 医学部附属病院, 教授 2005 – 2006: 東京大学, 医学部附属病院, 助教授 … More 2004: The University of Tokyo, Faculty of Medicine, Lecturer, 医学部附属病院, 講師 2002 – 2003: The University of Tokyo, Faculty of Medicine, Research Associate, 医学部附属病院, 助手 1995 – 2001: 東京大学, 医学部・附属病院, 助手 1997: 東京大学, 医学部附属病院, 助手 1995 – 1996: Univ.of Tokyo, Fac.of Med., Assistant Professor, 医学部(病), 助手 1993 – 1994: 東京大学, 医学部(病), 医員 1988: Faculty of Medicine, University of Tokyo, 医学部(病), 助手 1988: 東京大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology Except Principal Investigator Gastroenterology / Gastroenterology / Laboratory medicine / Metabolomics
Keywords	Principal Investigator スフィンゴシン1リン酸 / 肝再生 / Rho / Edg-5(S1P_2) / リゾフォスファチジン酸 / c-met / 星細胞 / HGF / 門脈圧亢進症 / 肝線維化 … More / 肝障害 / 臨床 / 脂質 / 癌 / セラミド / トランスレーショナルリサーチ / トランスレーショナル・リサーチ / S1Pリアーゼ / 大腸癌 / 肝細胞癌 / Platelet / Growth Factor / Epidermal Growth Factor / Liver Regeneration / イムノアッセイ / 血小板 / 増殖因子 / 上皮成長因子 / Liver damage / Liver cirrhosis / Liver fibrosis / Lysophosphatidic acid / Autotaxin / 肝硬変 / オートタキシン / liver regeneration / sphingosine 1-phosphate / EDG5 / LYSOPHOSPHATIDIC ACID / SPHINGOSINE 1-PHOSPHATE / HEPATIC STELLATE CELLS / PORTAL HYPERTENSION / スフィンゴシンコリン酸 / STELLATE CELLS / TGFbeta / ITO CELLS / TGFB / TGFβ / C-met / 伊東細胞 / 肝臓学 / 肝臓病学 … More Except Principal Investigator HGF / 肝細胞 / TGFα / 虚血再灌流障害 / 伊東細胞 / 栄養学 / 再生医学 / Kupffer細胞 / Ischemic preconditioning / 酸化ストレス / 生理活性 / 分子生物学 / NADPH oxidase / Leucine / Hepatocytes / ISCHEMIC PRECONDITIONING / ischemic preconditioning / 活性酸素 / 肝移植 / ICAM-1 / Rho-kinase / 肝星細胞 / Hepatic stellate cell / 星細胞 / 肝障害 / トランスレイショナルリサーチ / 生理活性脂質 / 移植・再生医療 / 臨床検査医学 / スレオニンプロテインキナーゼ / セリン / プロテインキナーゼ / 臨床検査 / リゾホスファチジン差 / アポタンパク質M / ホスファチジルセリン特異的ホスホリパーゼA1 / アポリポタンパク質M / オートタキシン / リゾホスファチジルセリン / スフィンゴシン1-リン酸 / リゾホスファチジン酸 / リゾリン脂質 / Bioactivity / Translational research / Nutrition / Regenerative medicine / トランスレイショナルリサー / Transplantation and regeneration / Oxidative stress / Oxygen radicals / Kupffer cells / reperfusion injury / Ischemia / reactive oxygen species(ROS) / ロイシン / LIVER TRANSPLANTATION / REPERFUSION INJURY / ISCHEMIA / 虚血再潅流障害 / LIPID PHOSPHATE PHOSPHOHYDROLASE / AUTOTAXIN / HEPATIC STELLATE CELLS / LYSOPHOSHATIDIC ACID / Auto taxin / Lysophospholipase D / 低分子量G淡白質Rho / Lipid phosphate phosphohydrolase / Autotaxin / Lysophosphatidic acid / functions / proliferation / 機能 / 増殖 / ADENOSINE / SUPEROXIDE / KUPFFER CELLS / ISCHEMIA REPERFUSION / LIVER TRASNPLANTATION / 活性酵素 / アデノシン / MACROPHAGE ACTIVATION / LIVER INJURY / ADHESION MOLECULE / HEPATOCYTE / マクロファージ活性化 / 接着分子 / phospholylation / cirrgotic liver / extracellular matrix / Rho Kinase / Rho / リン酸化 / 硬変肝 / Rho-Kinase / 細胞外マトリックス / diagnostic method / differentiation / hepatocellular carcinoma / immature form of TGFα / mature form of TGFα / pro TGFα / 診断法 / 分化度 / 肝細胞癌 / 非成熟型TGFα / 成熟型TGFα / proTGFα / COLLAGEN / RETINOL BINDING PROTEIN / STELLATE CELL / コラーゲン / レチノール結合蛋白 / RNA-binding domain / CUB domain / Liver fibrogenesis / Myofibroblast / Fat-storing cell / Stellate cell / Ito cell / 形質転換 / 活性化 / クローニング / 脂肪貯蔵細胞 / RNA結合ドメイン / CUBドメイン / 肝線維化 / 筋線維芽細胞 / Molecular biology / Non-parenchymal cell / Kupffer cell / Endothelial cell / threonine protein-kinase / Serine / protein-kinase / スレオニンプロティンキナーゼ / フッパー細胞 / 肝非実質細胞 / 肝類洞内皮細胞 / クッパー細胞 / 好中球 / マクロファージ / 肝虚血 / 内皮細胞障害 / エンドトキシン / 血管内凝固 / アルコール性肝炎 / 肝不全 / 食塩感受性 / 炎症 / アンジオテンシン / メタボリックシンドローム / 血管障害 / レニンアンジオテンシン / トランスレーショナルリサーチ / 内科 / 脂質過酸化 / 活性酸素ラジカル(ROS) / 血小板 / 脂質 / シグナル伝達 / 情報伝達 Less

Clarification of a role of sphingosine 1-phosphate in pathology of hepatocellular carcinoma, and its application for treatment strategyPrincipal Investigator
- Principal Investigator
  
  Ikeda Hitoshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Laboratory Medicine of Lysophospholipids
- Principal Investigator
  
  Yatomi Yutaka
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Laboratory medicine
- Research Institution
  The University of Tokyo
Stimulation of liver regeneration and function by IGF-I
- Principal Investigator
  
  TOMIYA Tomoaki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
A novel treatment for liver injury by modulation oflipid mediator effectsPrincipal Investigator
- Principal Investigator
  
  IKEDA Hitoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Induction of IGF-I production by amino acids in the liver : Its significance in the cirrhotic liver
- Principal Investigator
  
  TOMIYA Tomoaki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Pathophysiological mechanisms and therapeutic targets in multiple organ damages in metabolic syndrome
- Principal Investigator
  
  SHIMOSAWA Tatsuo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
短時間の虚血再潅流による酸化ストレスを介した肝細胞保護作用の制御・機序
- Principal Investigator
  
  TEJIMA Kazuaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Elucidation of a role of sphingosine 1-phosphate on liver damagePrincipal Investigator
- Principal Investigator
  
  IKEDA Hitoshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Analysis of platele-derived bioactive substances : establishment of platelet biology and its application into laboratory medicine
- Principal Investigator
  
  YATOMI Yutaka
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Laboratory medicine
- Research Institution
  The University of Tokyo
Modulation by amino acids of the expression of factors produced by hepatic stellate cells : its implication in injured liver
- Principal Investigator
  
  TOMIYA Tomoaki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Research for mechanisms of induction of hepatic ischemic tolerance by ischemic preconditioning.
- Principal Investigator
  
  TEJIMA Kazuaki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Elucidation of the clinical significance of autotaxin and lysophosphatidic acid in liver diseases.Principal Investigator
- Principal Investigator
  
  IKEDA Hitoshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Induction of hepatocyte growth factor by physiological agents : its effects on hepatocyte proliferation and protein production
- Principal Investigator
  
  TOMIYA Tomoaki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Functional Analysis of The Biological Activities of a Lipid Mediator, Lysophoshatidie Acid, on The Pathogenesis of Liver Fibrosis
- Principal Investigator
  
  YANASE Mikio
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Elucidation of the mechanism of the inhibitory effect of sphingosine 1-phosphate on hepatocyte proliferation and the significance in liver regenerationPrincipal Investigator
- Principal Investigator
  
  IKEDA Hitoshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
LIVER PROTECTION AGAINST ISCHEMIAJREPERFUSION INJURY BY ISCHEMIC PRECONDITIONING
- Principal Investigator
  
  ARAI Masahiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  THE UNIVERSITY OF TOKYO
Significance of growth factors for Hepatocyte proliferation and functions
- Principal Investigator
  
  TOMIYA Tomoaki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
PORTAL HYPERTENSION-ELUCIDATION OF THE MECHANISM IN THE LIGHT OF FUNCTIONAL ABNORMALITIES OF HEPATIC STELLATE CELLS AND DEVELOPMENT OF THERAPEUTIC STRATEGYPrincipal Investigator
- Principal Investigator
  
  IKEDA Hitoshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  THE UNIVERSITY OF TOKYO
MEASURES AGAINST HEPATIC FAILURE AFTER LIVER TRANSPLANTATION : BASIC INVESTIGATION ON PRECONDITIONING OF THE DONOR LIVER
- Principal Investigator
  
  ARAI Masahiro
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  THE UNIVERSITY OF TOKYO
Diagnostic method for differentiation of hepatocellular carcinoma : Determination of immature TGFα in blood and urine.
- Principal Investigator
  
  OGATA Itsuro
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tokyo
Extracellular matrix in liver cirrhosis : its abnormality and influence on liver functions.
- Principal Investigator
  
  OGATA Itsuro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tokyo
HEPATOCYTES AND ADHESION MOLECULE ICAM-1 : ITS EXPRESSION AND SIGNIFICANCE FOR LIVER INJURY.
- Principal Investigator
  
  OHNO Akihiko
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
ELUCIDATION OF SIGNIFICANCE OF c-met EXPRESSION IN ACTIVATED HEPATIC STELLATE GELLS AND ITS APPLICATION OF THERAPEUTIC STRATEGYPrincipal Investigator
- Principal Investigator
  
  IKEDA Hitoshi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  UNIVERSITY OF TOKYO
Cloning and characterization of newly described proteins from a fat-storing cell library : their significance in the activation of the cells.
- Principal Investigator
  
  OGATA Itsuro, ARAI Masahiro
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tokyo
THERAPY FOR HEPATIC FIBROSIS BY TARGETED DELIVERY OF ANTI-FIBROTIC AGENTS TO HEPATIC STELLATE CELLS
- Principal Investigator
  
  MASAKI Naohiko
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  UNIVERSITY OF TOKYO
Cloning and characterization of a possible adhesion molecule expressed by hepatic non-parenchymal cells
- Principal Investigator
  
  OGATA Itsuro
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tokyo
肝実質細胞機能の細胞外マトリックスによる調節機構の解明
- Principal Investigator
  
  OGATA Itsuro
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
アルコール性肝炎進展における虚血の関与とその機序の解明
- Principal Investigator
  
  尾形逸郎
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Platelet Epidermal Growth Factor and Liver RegenerationPrincipal Investigator
- Principal Investigator
  
  IKEDA Hitoshi, 岡裕爾
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tokyo

[Journal Article] Evidence Suggests Sphingosine 1-Phosphate Might Be Actively Generated, Degraded, and Transported to Extracellular Spaces With Increased S1P2 and S1P3 Expression in Colon Cancer.2017
- Author(s)
  Uranbileg B, Nishikawa T, Ikeda H, Kurano M, Sato M, Saigusa D, Aoki J, Watanabe T, Yatomi Y.
- Journal Title
  
  Clin Colorectal Cancer.
  
  Volume: Nov 21. pii: Issue: 2 Pages: 30369-9
- DOI
  10.1016/j.clcc.2017.11.004
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09343, KAKENHI-PROJECT-17K08233, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05906
[Journal Article] Resveratrol exerts a biphasic effect on apolipoprotein M.2016
- Author(s)
  Kurano M, Hara M, Nojiri T, Ikeda H, Tsukamoto K, Yatomi Y.
- Journal Title
  
  Br J Pharmacol
  
  Volume: 173 Issue: 1 Pages: 222-233
- DOI
  10.1111/bph.13360
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15378, KAKENHI-ORGANIZER-15H05897, KAKENHI-PROJECT-25253040, KAKENHI-PLANNED-15H05906
[Journal Article] Sphingosine kinase-1, S1P transporter spinster homolog 2 and S1P2 mRNA expressions are increased in liver with advanced fibrosis in human.2016
- Author(s)
  Sato M, Ikeda H, Uranbileg B, Kurano M, Saigusa D, Aoki J, Maki H, Kudo H, Hasegawa K, Kokudo N, Yatomi Y.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 32119-32119
- DOI
  10.1038/srep32119
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05906, KAKENHI-PROJECT-15K18842, KAKENHI-PROJECT-16K09343
[Journal Article] Increased mRNA Levels of Sphingosine Kinases and S1P Lyase and Reduced Levels of S1P Were Observed in Hepatocellular Carcinoma in Association with Poorer Differentiation and Earlier Recurrence.2016
- Author(s)
  Uranbileg B, Ikeda H, Kurano M, Enooku K, Sato M, Saigusa D, Aoki J, Ishizawa T, Hasegawa K, Kokudo N, Yatomi Y.
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 2 Pages: e0149462-e0149462
- DOI
  10.1371/journal.pone.0149462
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15378, KAKENHI-PROJECT-15K18842, KAKENHI-ORGANIZER-15H05897, KAKENHI-PROJECT-25253040, KAKENHI-PLANNED-15H05906, KAKENHI-PROJECT-16K09343
[Journal Article] Lysophosphatidylserine has Bilateral Effects on Macrophages in the Pathogenesis of Atherosclerosis2015
- Author(s)
  Nishikawa M, Kurano M, Ikeda H, Aoki J, Yatomi Y
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 22 Issue: 5 Pages: 518-526
- DOI
  10.5551/jat.25650
- NAID
  130004704381
- ISSN
  1340-3478, 1880-3873
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-15H05897, KAKENHI-PROJECT-25253040, KAKENHI-PROJECT-25293010
[Journal Article] Possible involvement of sphingomyelin in the regulation of the plasma sphingosine 1-phosphate level in human subjects2015
- Author(s)
  Ohkawa R, Kurano M, Mishima Y, Nojiri T, Tokuhara Y, Kishimoto T, Nakamura K, Okubo S, Hosogaya S, Ozaki Y, Yokota H, Igarashi K, Ikeda H, Tozuka M, Yatomi Y
- Journal Title
  
  Clinical Biochemistry
  
  Volume: 48 Issue: 10-11 Pages: 690-697
- DOI
  10.1016/j.clinbiochem.2015.03.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460671, KAKENHI-ORGANIZER-15H05897, KAKENHI-PROJECT-25253040
[Journal Article] A New Enzyme Immunoassay for the Quantitative Determination of Classical Autotaxins (ATXα, ATXβ, and ATXγ) and Novel Autotaxins (ATXδ and ATXε)2015
- Author(s)
  Tokuhara Y, Kurano M, Shimamoto S, Igarashi K, Nojiri T, Kobayashi T, Masuda A, Ikeda H, Nagamatsu T, Fujii T, Aoki J, Yatomi Y
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 6 Pages: e0130074-e0130074
- DOI
  10.1371/journal.pone.0130074
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-15H05897, KAKENHI-PROJECT-25253040
[Journal Article] LDL Receptor and ApoE are Involved in the Clearance of ApoM-associated Sphingosine 1-phosphate2015
- Author(s)
  Kurano M, Tsukamoto K, Hara M, Ohkawa R, Ikeda H, Yatomi Y.
- Journal Title
  
  J Biol Chem
  
  Volume: 290 Issue: 4 Pages: 2477-88
- DOI
  10.1074/jbc.m114.596445
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860740, KAKENHI-ORGANIZER-15H05897, KAKENHI-PROJECT-25253040
[Journal Article] Lysophosphatidylserine has Bilateral Effects on Macrophages in the Pathogenesis of Atherosclerosis2015
- Author(s)
  Nishikawa M, Kurano M, Ikeda H, Aoki J, Yatomi Y
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 22
- NAID
  130004704381
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25253040
[Journal Article] Possible involvement of minor lysophospholipids in the increase in plasma lysophosphatidic acid in acute coronary syndrome.2015
- Author(s)
  Kurano M, Suzuki A, Inoue A, Tokuhara Y, Kano K, Matsumoto H, Igarashi K, Ohkawa R, Nakamura K, Dohi T, Miyauchi K, Daida H, Tsukamoto K, Ikeda H, Aoki J, Yatomi Y
- Journal Title
  
  Arterioscler Thromb Vasc Biol
  
  Volume: 35 Issue: 2 Pages: 463-470
- DOI
  10.1161/atvbaha.114.304748
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-22116001, KAKENHI-PLANNED-22116004, KAKENHI-PROJECT-25253040, KAKENHI-ORGANIZER-15H05897, KAKENHI-PROJECT-26670021
[Journal Article] Blood levels of serotonin are specifically correlated with plasma lysophosphatidylserine among the glycero-lysophospholipids2015
- Author(s)
  Kurano M, Dohi T, Nojiri T, Kobayashi T, Hirowatari Y, Inoue A, Kano K, Matsumoto H, Igarashi K, Nishikawa M, Miyauchi K, Daida H, Ikeda H, Aoki J, Yatomi Y
- Journal Title
  
  BBA Clin
  
  Volume: 4 Pages: 92-98
- DOI
  10.1016/j.bbacli.2015.08.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-15H05897, KAKENHI-PROJECT-25253040
[Journal Article] Induction of insulin secretion by apolipoprotein M, a carrier for sphingosine 1-phosphate.2014
- Author(s)
  Kurano M, Hara M, Tsuneyama K, Sakoda H, Shimizu T, Tsukamoto K, Ikeda H, Yatomi Y.
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: 1841 Issue: 9 Pages: 1217-1226
- DOI
  10.1016/j.bbalip.2014.05.002
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390181, KAKENHI-PROJECT-25253040, KAKENHI-PROJECT-25670175, KAKENHI-PROJECT-25860740
[Journal Article] Lysophosphatidylserine stimulates chemotactic migration of colorectal cancer cells through GPR34 and PI3K/Akt pathway2014
- Author(s)
  Iida, Y. H. Tsuno N Kishikawa, J. Kaneko, K. Murono, K. Kawai, K. Ikeda, T. Ishihara, S. Yamaguchi, H. Sunami, E. Kitayama, J. Yatomi, Y. Watanabe, T.
- Journal Title
  
  Anticancer Res
  
  Volume: 34 Pages: 5465-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25253040
[Journal Article] Increased serum autotaxin levels in hepatocellular carcinoma patients were caused by background liver fibrosis but not by carcinoma2014
- Author(s)
  Kondo M, Ishizawa T, Enooku K, Tokuhara Y, Ohkawa R, Uranbileg B, Nakagawa H, Tateishi R, Yoshida H, Kokudo N, Koike K, Yatomi Y, Ikeda H
- Journal Title
  
  Clin Chim Acta
  
  Volume: 433C Pages: 128-134
- DOI
  10.1016/j.cca.2014.03.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23689060, KAKENHI-PROJECT-25253040, KAKENHI-PROJECT-25460981
[Journal Article] Modulation of sphingosine-1-phosphate and apolipoprotein M levels in the plasma, liver and kidneys in streptozotocin-induced diabetic mice2014
- Author(s)
  Nojiri T, Kurano M, Tokuhara Y, Ohkubo S, Hara M, Ikeda H, Tsukamoto K, Yatomi Y
- Journal Title
  
  J Diabetes Investig
  
  Volume: 5 Issue: 6 Pages: 639-48
- DOI
  10.1111/jdi.12232
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25253040, KAKENHI-PROJECT-25860740
[Journal Article] High ubiquitous mitochondrial creatine kinase expression in hepatocellular carcinoma denotes a poor prognosis with highly-malignant potential2014
- Author(s)
  Uranbileg B, Enooku K, Soroida Y, Ohkawa R, Kudo Y, Nakagawa H, Tateishi R, Yoshida H, Shinzawa S, Moriya K, Ohtomo N, Nishikawa T, Inoue Y, Tomiya T, Koike K, Yatomi Y, Ikeda H
- Journal Title
  
  Int J Cancer
  
  Volume: 134 Pages: 2189-2198
- Data Source
  KAKENHI-PROJECT-23590961
[Journal Article] Liver involvement in sphingosine 1-phosphate dynamism revealed by adeniviral hepatic overexpression of apolipoprotein M.2013
- Author(s)
  Kurano M, Tsukamoto K, Ohkawa R, Hara M, Iino J, Kageyama Y, Ikeda H, Yatomi Y.
- Journal Title
  
  Atherosclerosis
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590716
[Journal Article] Induction of p53-dependent p21 limits proliferative activity of rat hepatocytes in the presence of hepatocyte growth factor2013
- Author(s)
  Inoue Y, Tomiya T, Nishikawa T, Ohtomo N, Tanoue Y, Ikeda H, Koike K
- Journal Title
  
  PLoS One
  
  Volume: 8
- Data Source
  KAKENHI-PROJECT-23590961
[Journal Article] High ubiquitous mitochondrial creatine kinase expression in hepatocellular carcinoma denotes a poor prognosis with highly malignant potential.2013
- Author(s)
  Uranbileg B, Enooku K, Soroida Y, Ohkawa R, Kudo Y, Nakagawa H, Tateishi R, Yoshida H, Shinzawa S, Moriya K, Ohtomo N, Nishikawa T, Inoue Y, Tomiya T, Kojima S, Matsuura T, Koike K, Yatomi Y, Ikeda H.
- Journal Title
  
  Int J Cancer.
  
  Volume: 134 Issue: 9 Pages: 2189-98
- DOI
  10.1002/ijc.28547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590961, KAKENHI-PROJECT-24390183, KAKENHI-PROJECT-25460981
[Journal Article] Induction of p53-dependent p21 limits proliferative activity of rat hepatocytes in the presence of hepatocyte growth factor.2013
- Author(s)
  Inoue Y, Tomiya T, Nishikawa T, Ohtomo N, Tanoue Y, Ikeda H, Koike K.
- Journal Title
  
  PLoS One.
  
  Volume: 8 Issue: 11 Pages: e78346-e78346
- DOI
  10.1371/journal.pone.0078346
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590961
[Journal Article] Sphingosine-1-phosphate as a mediator involved in development of fibrotic diseases2013
- Author(s)
  Takuwa Y
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 183 Issue: 1 Pages: 185-192
- DOI
  10.1016/j.bbalip.2012.06.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590284, KAKENHI-PROJECT-22590716, KAKENHI-PROJECT-23590257, KAKENHI-PROJECT-23590344, KAKENHI-PROJECT-23659170, KAKENHI-PROJECT-24390051, KAKENHI-PUBLICLY-23116509
[Journal Article] Liver involvement in sphingosine 1-phosphate dynamism revealed by adenoviral hepatic overexpression of apolipoprotein M2013
- Author(s)
  Kurano, M., Tsukamoto, K., Ohkawa, R., Hara, M., Iino, J., Kageyama, Y., Ikeda, H., and Yatomi, Y.
- Journal Title
  
  Atherosclerosis
  
  Volume: 229 Issue: 1 Pages: 102-109
- DOI
  10.1016/j.atherosclerosis.2013.04.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25253040
[Journal Article] リゾリン脂質と肝臓疾患2012
- Author(s)
  池田均
- Journal Title
  
  臨床検査
  
  Volume: 56 Pages: 209-212
- Data Source
  KAKENHI-PROJECT-22590716
[Journal Article] Antagonism of sphingosine 1-phosphate receptor 2 causes a selective reduction of portal vein pressure in bile duct-ligated rats2012
- Author(s)
  Kegeyama Y
- Journal Title
  
  Hepatology
  
  Volume: 56 Issue: 4 Pages: 1427-1438
- DOI
  10.1002/hep.25780
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590284, KAKENHI-PROJECT-22590716, KAKENHI-PROJECT-23590961, KAKENHI-PROJECT-23591213, KAKENHI-PROJECT-23659170, KAKENHI-PUBLICLY-23116509
[Journal Article] Antagonism of sphingosine 1-phosphate receptor 2 causes a selective reduction of portal vein pressure in bile duct-ligated rodents2012
- Author(s)
  Kageyama Y, Ikeda H, Watanabe N, Nagamine M, Kusumoto Y, Yashiro M, Satoh Y, Shimosawa T, Shinozaki K, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Yokota H, Koyama T, Ishimaru K, Okamoto Y, Takuwa Y, Koike K, Yatomi Y
- Journal Title
  
  Hepatology
  
  Volume: 56 Pages: 1427-38
- Data Source
  KAKENHI-PROJECT-23590961
[Journal Article] Prediction of hepatocellular carcinoma development by plasma ADAMTS13 in chronic hepatitis B and C2011
- Author(s)
  Ikeda H, Tateishi R, Enooku K, Yoshida H, Nakagawa H, Masuzaki R, Kondo Y, Goto T, Shiina S, Kume Y, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Ono T, Koike K, Yatomi Y
- Journal Title
  
  Cancer Epidemiol Biomarkers Prev
  
  Volume: 20 Pages: 2204-11
- Data Source
  KAKENHI-PROJECT-23590961
[Journal Article] Autotaxin as a novel serum marker of liver fibrosis2011
- Author(s)
  Nakagawa H, Ikeda H, Nakamura K, Ohkawa R, Masuzaki R, Tateishi R, Yoshida H, Watanabe N, Tejima K, Kume Y, Iwai T, Suzuki A, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Omata M, Igarashi K, Aoki J, Koike K, Yatomi Y
- Journal Title
  
  Clin Chim Acta
  
  Volume: 412 Pages: 1201-6
- Data Source
  KAKENHI-PROJECT-23590961
[Journal Article] Autotaxin as a novel serum marker of liver fibrosis.2011
- Author(s)
  Nakagawa H, Ikeda H, Nakamura K, Watanabe N, Tejima K, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Omata M, Igarashi K, Aoki J, Koike K, Yatomi Y.
- Journal Title
  
  Clin Chim Acta
  
  Volume: 412 Pages: 1201-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590961
[Journal Article] Prediction of hepatocellular carcinoma development by plasma ADAMTS13 in chronic hepatitis B and C.2011
- Author(s)
  Ikeda H, Tateishi R, Enooku K, Yoshida H, Nakagawa H, Masuzaki R, Kondo Y, Goto T, Shiina S, Kume Y, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Ono T, Koike K, Yatomi Y.
- Journal Title
  
  Cancer Epidemiol Biomarkers Prev
  
  Volume: 20 Pages: 2204-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590961
[Journal Article] Increased production of ADAMTS13 in hepatic stellate cells contributes to enhanced plasma ADAMTS13 activity in rat models of cholestasis and steatohepatitis.2010
- Author(s)
  Watanabe N, Ikeda H, Kume Y, Satoh Y, Kaneko M, Takai D, Tejima K, Nagamine M, Mashima H, Tomiya T, Noiri E, Omata M, Matsumoto M, Fujimura Y, Yatomi Y
- Journal Title
  
  Thromb Haemost 102
  
  Pages: 389-396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590761
[Journal Article] Expression of alpha-taxilin in hepatocellular carcinoma correlates with growth activity and malignant potential of the tumor.2010
- Author(s)
  Ohtomo N, Tomiya T, Tanoue Y, Inoue Y, Nishikawa T, Ikeda H, Seyama Y, Kokudo N, Shibahara J, Fukayama M, Koike K, Shirataki H, Fujiwara K
- Journal Title
  
  Int J Oncol 37
  
  Pages: 1417-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590761
[Journal Article] plasma level of bioactive lipid mediator sphingosine 1-phosphate is reduced in patients with chronic hepatitis C.2010
- Author(s)
  Ikeda H, Ohkawa R, Watanabe N, Nakamura K, Kume Y, Nakagawa H, Yoshida H, Okubo S, Yokota H, Tomiya T, et al.
- Journal Title
  
  Clin Chim Acta
  
  Volume: 416 Pages: 765-770
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590761
[Journal Article] Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2.2010
- Author(s)
  Ikeda H, Watanabe N, Ishii I, Shimosawa T, Kume Y, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Iitsuka S, Fujita R, Omata M, Chun J, Yatomi Y
- Journal Title
  
  J Lipid Res 50
  
  Pages: 556-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590761
[Journal Article] Plasma level of bioactive lipid mediator sphingosine 1-phosphate is reduced in patients with chronic hepatitis C.2010
- Author(s)
  Ikeda H, Ohkawa R, Watanabe N, Nakamura K, Kume Y, Nakagawa H, Yoshida H, Okubo S, Yokota H, Tomiya T, Nishikawa T, Ohtomo N, Tanoue Y, Koike K, Yatomi Y
- Journal Title
  
  Clin Chim Acta 411
  
  Pages: 765-770
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590761
[Journal Article] Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via shinosine 1-phosphate receptor 2(SIP2).2009
- Author(s)
  Hitoshi Ikeda et al.
- Journal Title
  
  Journal of Lipid Research 50
  
  Pages: 556-564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590750
[Journal Article] Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2.2009
- Author(s)
  Ikeda, H., Watanabe, N., Ishii, I., Shimosawa.T., Kume, Y., Tomiya, T., Inoue, Y., Nishikawa, T., Ohtomo, N., Tanoue, Y., Iitsuka, S., Fujita, R., Omata, M., Chun, J., Yatomi, Y.
- Journal Title
  
  J.Lipid Res. 50
  
  Pages: 556-564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591048
[Journal Article] Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2.2009
- Author(s)
  Ikeda H, Watanabe N, Ishii I, Shimosawa T, Kume Y, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, et al.
- Journal Title
  
  J Lipid Res 50
  
  Pages: 556-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590761
[Journal Article] Increased production of ADAMTS13 in hepatic stellate cells contributes to enhanced plasma ADAMTS13 activity in rat models of cholestasis and steatohepatitis.2009
- Author(s)
  Watanabe N, Ikeda H, Kume Y, Satoh Y, Kaneko M, Takai D, Tejima K, Nagamine M, Mashima H, Tomiya T, et al.
- Journal Title
  
  Thrombo Haemost 102
  
  Pages: 389-396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590761
[Journal Article] Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2.2009
- Author(s)
  Ikeda H., Watanabe N., Ishii I., Shimosawa T., Kume Y., Tomiya T., Inoue Y., Nishikawa T., Ohtomo N., Tanoue Y., Iitsuka S., Fujita R., Omata M., Chun J., Yatomi Y.
- Journal Title
  
  J.Lipid Res. 50
  
  Pages: 556-564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591048
[Journal Article] Sphingosine1-phosphate regulates regeneration and fibrosisafter liver injury via sphingosine 1-phosphate receptor 2(S1P_2)2009
- Author(s)
  Ikeda H., Watanabe N., Ishii I., Shimosawa T.,Kume Y., Tomiya T., Inoue Y., Nishikawa T., Ohtomo N., Tanoue Y., Iitsuka S., Fujita R., Omata M., Chun J., Yatomi Y.
- Journal Title
  
  Journal of Lipid Research
  
  Pages: 556-564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590750
[Journal Article] Increased production of ADAMTS13 in hepatic stellate cells contributes to enhanced plasma ADAMTS13 activity in rat models of cholestasis and steatohepatitis2009
- Author(s)
  Watanabe, N., Ikeda, H., Kume, Y., Satoh, Y., Kaneko, M., Takai, D., Tejima, K., Nagamine, M., Mashima, H., Tomiya, T., Noiri, E., Omata, M., Matsumoto, M., Fujimura, Y., Yatomi, Y.
- Journal Title
  
  Thromb.Haemost. 102
  
  Pages: 389-396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209020
[Journal Article] Autotaxin enzyme immunoassay in human cerebrospinal fluid samples2009
- Author(s)
  Nakamura, K., Ohkawa, R., Okubo, S., Yokota, H., Ikeda, H., Yatomi, Y., Igarashi, K., Ide, K., Kishimoto, T., Masuda, A., Yamamoto, T., Tsuji, S., Saito, N., Kurokawa, M., Okudaira, S., Aoki, J.
- Journal Title
  
  Clin.Chim.Acta 405
  
  Pages: 160-162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209020
[Journal Article] Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 22009
- Author(s)
  Ikeda, H., Watanabe, N., Ishii, I., Shimosawa, T., Kume, Y., Tomiya, T., Inoue, Y., Nishikawa, T., Ohtomo, N., Tanoue, Y., litsuka, S., Fujita, R., Omata, M., Chun, J., Yatomi, Y.
- Journal Title
  
  J.Lipid Res. 50
  
  Pages: 556-564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209020
[Journal Article] Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injuryvia sphingosine 1-phosphate receptor 2.2008
- Author(s)
  Ikeda H, Watanabe. N, Ishii I, Shimosawa T, Kume Y, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, et al.
- Journal Title
  
  J Lipid Res 50
  
  Pages: 556-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590761
[Journal Article] Validation of an autotaxin enzyme immunoassay in human serum samples and its application to hypoalbuminemia differentiation2008
- Author(s)
  Nakamura, K., Igarashi, K., Ide, K., Ohkawa, R., Okubo, S., Yokota, H., Masuda, A., Oshima, N., Takeuchi, T., Nangaku, M., Okudaira, S., Arai, H., Ikeda, H., Aoki, J., Yatomi, Y.
- Journal Title
  
  Clin.Chim.Acta 388
  
  Pages: 51-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209020
[Journal Article] Plasma sphingosine-1-phosphate measurement in healthy subjects : close correlation with red blood cell parameters2008
- Author(s)
  Ohkawa, R., Nakamura, K., Okubo, S., Hosogaya, S., Ozaki, Y., Tozuka, M., Osima, N., Yokota, H., Ikeda, H., Yatomi, Y.
- Journal Title
  
  Ann.Clin.Biochem. 45
  
  Pages: 356-363
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209020
[Journal Article] Serum autotaxin measurement in haematological malignancies : a promising marker for follicular lymphoma2008
- Author(s)
  Masuda, A., Nakamura, K., Izutsu, K., Igarashi, K., Ohkawa, R., Jona, M., Higashi, K., Yokota, H., Okudaira, S., Kishimoto, T., Watanabe, T., Koike, Y., Ikeda, H., Kozai, Y., Kurokawa, M., Aoki, J., Yatomi, Y.
- Journal Title
  
  Br.J.Haematol. 143
  
  Pages: 60-70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209020
[Journal Article] Analysis of serum and urinary lysophospholipase D/autotaxin in nephrotic syndrome2008
- Author(s)
  Nakamura, K., Nangaku, M., Ohkawa, R., Okubo, S., Yokota, H., Ikeda, H., Aoki, J., Yatomi, Y.
- Journal Title
  
  Clin.Chem.Lab.Med. 46
  
  Pages: 150-151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209020
[Journal Article] Induction of ischemic tolerance in rat liver via reduced nicotinamide adenine dinucleotide phosphate oxidase in Kupffer cells.2007
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, et. al.
- Journal Title
  
  World J Gastroenterol 13(38)
  
  Pages: 5071-5078
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590749
[Journal Article] Effect of rapamycin on hepatocyte function and proliferation induced by growth factors.2007
- Author(s)
  Tomiya T, Yamaoka M, Inoue Y, Nishikawa T, Yanase M, Ikeda H, Tejima K, Nagashima K, Watanabe N, Omata M, Fujiwara K.
- Journal Title
  
  Chemotherapy 53
  
  Pages: 59-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Induction of ischemic tolerance in rat liver via reduced nicotinamide adenine dinucleotide phosphate oxidase in Kupffer cells.2007
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, Yanase M, moue Y, Nishikawa T, Watanabe N, Ohtomo N, Omata M, fujiwara K.
- Journal Title
  
  World J Gastroenterol 13
  
  Pages: 5071-5078
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Suppression of lysophosphatidic acid and lysophosphatidylcholine formation in the plasma in vitro : Proposal of a plasma sample preparation method for laboratory testing of these lipids2007
- Author(s)
  Nakamura, K., Kishimoto, T., Ohkawa, R., Okubo, S., Tozuka, M., Yokota, H., Ikeda, H., Ohshima, N., Mizuno, K., Yatomi, Y.
- Journal Title
  
  Anal.Biochem. 367
  
  Pages: 20-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209020
[Journal Article] Leucine stimulates HGF production by hepatic stellate cells through mTOR pathway2007
- Author(s)
  Tomiya T, Nishikawa T, Inoue Y, Ohtomo N, Ikeda H, Tejima K, Watanabe N, Tanoue Y, Omate, M, Fujiwara K.
- Journal Title
  
  Biochem Biophys Res Common 358
  
  Pages: 176-180
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Stimulation by glutamine and proline of HGF production in hepatic stellate cells.2007
- Author(s)
  Nishikawa T, Tomiya T, Ohtomo N, Inoue Y, Ikeda H, Tejima K, Watanabe N, Tanoue Y, Omata M, Fujiwara K.
- Journal Title
  
  Biochem Biophys Res Commun 363
  
  Pages: 978-982
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Induction of ischemic tolerance in rat liver via reduced nicotinamide adenine dinucleotide phosphate oxidase in Kupffer cells2007
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, Yanase M, Inoue Y, Nishikawa T, Watanabe N, Ohtomo N, Omata M, Fujiwara K.
- Journal Title
  
  World J Gastroenterol 13
  
  Pages: 5071-5078
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Measurement of lysophospholipase D/autotaxin activity in human serum samples2007
- Author(s)
  Nakamura, K., Ohkawa, R., Okubo, S., Tozuka, M., Okada, M., Aoki, S., Aoki, J., Arai, H., Ikeda, H., Yatomi, Y.
- Journal Title
  
  Clin.Biochem. 40
  
  Pages: 274-277
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209020
[Journal Article] Both Plasma Lysophosphatidic Acid and Serum Autotaxin Levels are Increased in Chronic Hepatitis2007
- Author(s)
  Watanabe, N., Ikeda, H., Nakamura, K., Ohkawa, R., Kume, Y., Aoki, J., Hama, K., Okudaira, S., Tanaka, M., Tomiya, T., Yanase, M., Tejima, K., Nishikawa, T., Arai, M., Arai, H., Omata, M., Fujiwara, K., Yatomi, Y.
- Journal Title
  
  C.J.Clin.Gastroenterol. 41
  
  Pages: 616-623
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209020
[Journal Article] Rho-kinase inhibitor prevents hepatocyte damage in acute liver injury induced by carbon tetrachloride in rats.2007
- Author(s)
  Ikeda H, Kume Y, Tejima K, Tomiya T, Nishikawa T, Watanabe N, Ohtomo N, Arai M, Arai C, Omata M, Fujiwara K, Yatomi Y.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 293
  
  Pages: 911-917
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Rho-kinase inhibitor prevents hepatocyte damage in acute liver injury induced by carbon tetrachloride in rats2007
- Author(s)
  Ikeda H, Kume Y, Tejima K, Tomiya T, Nishikawa T, Watanabe N, Ohtomo N, Arai M, Arai C, Omata M, Fujiwara K, Yatomi Y.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 293
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Oxygen radical production by NADPH oxidase in Kupffer cells promotes hepatic ischemic tolerance.2007
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T et al.
- Journal Title
  
  Hepatology International 1(1)
  
  Pages: 215-215
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590615
[Journal Article] Ischemic preconditioning in liver pathophysiology.2007
- Author(s)
  Arai M, Tejima K, Ikeda H, Tomiya T, et. al.
- Journal Title
  
  J Gastroenterol Hepatol 22(1)
  
  Pages: 65-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590749
[Journal Article] Stimulation by glutamine and proline of HGF production in hepatic stellate cells2007
- Author(s)
  Nishikawa T, Tomiya T, Ohtomo N, Inoue Y, Ikeda H, Tejima K, Watanabe N, Tanoue Y, Omata M, Fujiwara K.
- Journal Title
  
  Biochem Biophys Res Commun 363
  
  Pages: 978-982
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Effect of rapamycin on hepatocyte function and proliferation induced by growth factors2007
- Author(s)
  Tomiya T, Yamaoka M, Inoue Y, Nishikawa T, Yanase M, Ikeda H, Tejima K, Nagashima K, Watanabe N, Omata M, Fujiwara K.
- Journal Title
  
  Chemotherapy 53
  
  Pages: 59-69
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Effect of rapamycin on hepatocyte function and proliferation induced by growth factors.2007
- Author(s)
  Tomiya T, Yamaoka M, Inoue Y, Nishikawa T, Yanase M, Ikeda H, Tejima K, et al.
- Journal Title
  
  Chemotherapy 53・1
  
  Pages: 59-69
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C.2007
- Author(s)
  Watanabe N, Ikeda H, Nakamura K, Obkawa R, Kume Y, Aoki J, Hama K, Okudaira S, Tanaka M, Tonriya T, Yanase M, Tejima K, Nishikawa T, Arai M, Arai H, Omata M, Fujiwara K, Yatomi Y.
- Journal Title
  
  J Clin Gastroenterol 41
  
  Pages: 616-623
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Leucine stimulates HGF production by hepatic stellate cells through mTOR pathway.2007
- Author(s)
  Tomiya T, Nishikawa T, Inoue Y, Ohtomo N, Ikeda H, Tejima K, Watanabe N, Tanoue Y, Omata M. Fujiwara K
- Journal Title
  
  Biochem Biophys Res Commun 358
  
  Pages: 176-180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Serum lysophospholipase D/autotaxin may be a new nutritional assessment marker : study on prostate cancer patients2007
- Author(s)
  Nakamura, K., Takeuchi, T., Ohkawa, R., Okubo, S., Yokota, H., Tozuka, M., Aoki, J., Arai, H., Ikeda, H., Ohshima, N., Kitamura, T., Yatomi, Y.
- Journal Title
  
  Ann.Clin.Biochem. 44
  
  Pages: 549-556
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209020
[Journal Article] Ischemic preconditioning in liver pathophysiology2007
- Author(s)
  Arai M, Tejima K, Ikeda H, Tomiya T, Yanase M, Inoue Y, Nagashima K, Nishikawa T, Watanabe N, Omata M, Fujiwara K.
- Journal Title
  
  J Gastroenterol Hepatol 22 : S1
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Hepatic stellate cell damage may lead to decreased plasma ADAMTS13 activity in rats2007
- Author(s)
  Kume Y, Ikeda H, Inoue M, Tejima K, Tomiya T, Nishikawa T, Watanabe N, Ichikawa T, Kaneko M, Okubo S, Yokota H, Omata M, Fujiwara K, Yatomi Y
- Journal Title
  
  FEBS Lett 581
  
  Pages: 1631-1634
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity2007
- Author(s)
  Watanabe, N., Ikeda, H., Nakamura, K., Ohkawa, R., Kume, Y., Tomiya, T., Tejima, K., Nishikawa, T., Arai, M., Yanase, M., Aoki, J., Arai, H., Omata, M., Fujiwara, K., Yatomi, Y.
- Journal Title
  
  Life Sci. 81
  
  Pages: 1009-1015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209020
[Journal Article] Leucine stimulates HGF production by hepatic stellate cells through mTOR pathway2007
- Author(s)
  Tomiya T, Nishikawa T, Inoue Y, Ohtomo N, Ikeda H, Tejima K, et al.
- Journal Title
  
  Biochemical And Biophysical Research Communications (印刷中)
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Hepatic stellate cell damage may lead to decreased plasma ADAMTS13 activity in rats2007
- Author(s)
  Kume Y, Ikeda H, Inoue M, Tejima K, Tomiya T, Nishikawa T, Watanabe N, Ichikawa T, Kaneko M, Okubo S, Yokota H, Omata M, Fujiwara K, Yatomi Y.
- Journal Title
  
  FEBS Lett 581
  
  Pages: 1631-1634
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity2007
- Author(s)
  Watanabe N, Ikeda H, Nakamura K, Ohkawa R, Kume Y, Tomiya T, Tejima K, Nishikawa T, Arai M, Yanase M, Aoki J, Arai H, Omata M, Fujiwara K, Yatomi Y.
- Journal Title
  
  Life Sci 81
  
  Pages: 1009-1015
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Rho-kinase inhibitor prevents hepatocyte damage in acute liver injury induced by carbon tetrachloride in rats2007
- Author(s)
  Ikeda, H., Kume, Y., Tejima, K., Tomiya, T., Nishikawa, T., Watanabe, N., Ohtomo, N., Arai, M., Arai, C., Omata, M., Fujiwara, K., Yatomi, Y.
- Journal Title
  
  Am.J.Physiol.Gastrointest.Liver Physiol. 293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209020
[Journal Article] Leucine stimulates HGF production by hepatic stellate cells through mTOR pathway.2007
- Author(s)
  Tomiya T, Nishikawa T, Inoue Y, Ohtomo N, Ikeda H, Tejima K, Watanabe N, Tanoue Y, Omata M, Fujiwara K.
- Journal Title
  
  Biochem Biophys Res Commun 358
  
  Pages: 176-180
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Oxygen radical production by NADPH oxidase in Kupffer cells promotes hepatic ischemic tolerance.2007
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, et al.
- Journal Title
  
  Hepatology International 1(1)
  
  Pages: 215-215
- Data Source
  KAKENHI-PROJECT-17590615
[Journal Article] Hepatic stellate cell damage may lead to decreased plasma ADAMTS13 activity in rats.2007
- Author(s)
  Kume Y, Ikeda H, Inoue M, Tejima K, Tomiya T, Nishikawa T, Watanabe N, et al.
- Journal Title
  
  FEBS Letters 58・18
  
  Pages: 1631-1634
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Plasma 1ysophosphatidic acid level and serum autotaxin activity are increased in in liver injury in rats in relation to its severity2007
- Author(s)
  Watanabe N, Ikeda H, Nakamura K, Ohkawa R, Kume Y, Tomiya T, Tejima K, Nishikawa T, Arai M, Yanase M, Aoki J, Arai H, Omata M Fujiwara K, Yatomi Y.
- Journal Title
  
  Life Sci 81
  
  Pages: 1009-1015
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Hepatic stellate cell damage may lead to decreased plasma ADAMTS13 activity in rats2007
- Author(s)
  Kume, Y., Ikeda, H., Inoue, M., Tejima, K., Tomiya, T., Nishikawa, T., Watanabe, N., Ichikawa, T., Kaneko, M., Okubo, S., Yokota, H., Omata, M., Fujiwara, K., Yatomi, Y.
- Journal Title
  
  FEBS Lett. 581
  
  Pages: 1631-1634
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209020
[Journal Article] Oxygen radical production by NADPH oxidase in Kupffer cells promotes hepatic ischemic tolerance.2007
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T et al.
- Journal Title
  
  Hepatology International 1 (1)
  
  Pages: 215-215
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590615
[Journal Article] The herbal medicine inchin-ko-to (TJ-135) induces apoptosis in cultured rat hepatic stellate cells2006
- Author(s)
  Ikeda, H., Nagashima, K., Yanase, M., Tomiya, T., Arai, M., Inoue, Y., Tejima, K., Nishikawa, T., Watanabe, N., Kitamura, K., Isono, T., Yahagi, N., Noiri, E., Inao, M., Mochida, S., Kume, Y., Yatomi, Y., Nakahara, K., Omata, M., Fujiwara, K.
- Journal Title
  
  Life Sci. 78
  
  Pages: 2226-2233
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209020
[Journal Article] The herbal medicine inchin-ko-to (TJ-135) induces apoptosis in cultured rat hepatic stellate cells.2006
- Author(s)
  Ikeda H, Nagashima K, Yanase M, Tomiya T, Arai M, Inoue Y, Tejima K, et al.
- Journal Title
  
  Life Sciences 78・19
  
  Pages: 2226-2233
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Hepatocyte preconditioning via activation of NADPH oxidase in Kupffer cells against warm ischemia/reperfusion injury.2005
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, Yanase M, et al.
- Journal Title
  
  Hepatology 42(4)
- Data Source
  KAKENHI-PROJECT-17590615
[Journal Article] Hepatocyte preconditioning via activation of NADPH oxidase in Kupffer cells against warm ischemia/reperfusion injury.2005
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, Yanase M et al.
- Journal Title
  
  Hepatology 42(4)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590615
[Journal Article] Ischemic preconditioning protects hepatocytes via reactive oxygen species derived from Kupffer cells in rats.2004
- Author(s)
  Tajima K, Arai M, Ikeda H, Tomiya T, Yanase M, et al.
- Journal Title
  
  Gastroenterology 127
  
  Pages: 1488-1496
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation.2004
- Author(s)
  Ikeda H, Nagashima K, Yanase M, Tomiya T, Arai M, et al.
- Journal Title
  
  Biochem Biophys Res Commun. 320
  
  Pages: 754-759
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation.2004
- Author(s)
  Ikeda H, Nagashima K, Yanase M, Tomiya T, Arai M, et al.
- Journal Title
  
  Biochem Biophys Res Commun 320
  
  Pages: 754-759
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Treatment with leucine stimulates the production of hepatocyte growth factor in vivo.2004
- Author(s)
  Tomiya T, Inoue Y, Yanase M, Arai M, Ikeda H et al.
- Journal Title
  
  Biochem Biophys Res Commun. 322
  
  Pages: 772-777
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Ischemic preconditioning protects hepatocytes via reactive oxygen species derived from Kupffer cells in rats.2004
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, Yanase M, et al.
- Journal Title
  
  Gastroenterology 127
  
  Pages: 1488-1496
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] HMG-COA reductase inhibitor modulates collagen GEL-contraction by hepatic myofibroblast-like stellate cell line : involvement of geranylgeranylated proteins.2004
- Author(s)
  Yanase M, Ikeda H, Matsui A, Noiri E, Tomiya T, et al.
- Journal Title
  
  Comp Hepatol. 3
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] HMG-COA reductase inhibitor modulates collagen GEL-contraction by hepatic myofibroblast-like stellate cell line : involvement of geranylgeranylated proteins.2004
- Author(s)
  Yanase M, Ikeda H, Matsui A, Noiri E, Tomiya T, et al.
- Journal Title
  
  Comp Hepatol 3
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Functional Diversity between Rho-Kinase-and MLCK-Mediated Cytoskeletal Actions in a Myofibroblast-Like Hepatic Stellate Cell Line.2003
- Author(s)
  Yanase M, Ikeda H, Ogata I, Matsui A, Noiri E, Tomiya T, et al.
- Journal Title
  
  Biochem Biophys Res Commun 305
  
  Pages: 223-228
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Functional Diversity between Rho-Kinase and MLCK-Mediated Cytoskeletal Actions in a Myofibroblast-Like Hepatic Stellate Cell Line.2003
- Author(s)
  Yanase M, Ikeda H, Ogata I, Matsui A, Noiri E, Tomiya T, et al.
- Journal Title
  
  Biochem Biophys Res Commun. 305
  
  Pages: 223-228
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Antiproliferative Property of Sphingosine 1-Phosphate in Rat Hepatocytes Involves Activation of Rho Via Edg-5.2003
- Author(s)
  Ikeda H, Satoh H, Yanase M, Inoue Y, Tomiya T, et al.
- Journal Title
  
  Gastroenterology 124
  
  Pages: 459-469
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Involvement of Rho/Rho kinase pathway in regulation of apoptosis in rat hepatic stellate cells.2003
- Author(s)
  Ikeda H, Nagashima K, Yanase M, Tomiya T, et al.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 285
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C.
- Author(s)
  Watanabe N, Ikeda H et al.
- Journal Title
  
  Journal of Clinical Gastroenterology (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590618
[Journal Article] Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C.
- Author(s)
  Watanabe N, Ikeda H et al.
- Journal Title
  
  Journal of Clinical Gastroenterology In press
- Data Source
  KAKENHI-PROJECT-17590618
[Journal Article] Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C.
- Author(s)
  Watanabe N, Ikeda H, et al.
- Journal Title
  
  Journal of Clinical Gastroenterology (In Press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590618
[Patent] オートタキシン測定による肝線維化の検査方法および検査薬2009
- Inventor(s)
  矢冨裕, 中村和宏, 池田均, 五十嵐浩二
- Industrial Property Number
  2009-298048
- Filing Date
  2009-12-28
- Data Source
  KAKENHI-PROJECT-18209020
[Patent] 天然形態ヒトオートタキシン特異的抗体, そのスクリーニング方法, 及びオートタキシン測定による悪性リンパ腫の検査方法および検査薬2007
- Inventor(s)
  青木淳賢, 新井洋由, 矢冨裕, 池田均, 中村和宏, 五十嵐浩二, 井出和史
- Filing Date
  2007-08-02
- Data Source
  KAKENHI-PROJECT-18209020
[Patent] 天然形態ヒトオートタキシン特異的抗体及びそのスクリーニング方法2006
- Inventor(s)
  青木淳賢, 新井洋由, 矢冨裕, 池田均, 中村和宏, 五十嵐浩二, 井出和史
- Industrial Property Number
  2006-212275
- Filing Date
  2006-08-03
- Data Source
  KAKENHI-PROJECT-18209020
[Presentation] The importance of S1P lyase in the pathophysiology of hepatocellular carcinoma and colon cancer.2018
- Author(s)
  Uranbileg B, Ikeda H, Kurano M, Saigusa D, Kano K, Aoki J, and Yatomi Y.
- Organizer
  The 15th Congress of the Asian Society for Clinical Pathology and Laboratory Medicine (ASCPaLM). September 6-8th 2018, Ulaanbaatar, Mongolia.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09343
[Presentation] S1P is actively metabolized and transported to extracellular spaces with increased receptors expression in colon cancer2017
- Author(s)
  Uranbileg B, Nishikawa T, Ikeda H, Kurano M, Sato M, Saigusa D, Aoki J, Watanabe T, Yatomi Y.
- Organizer
  29th World Congress of World Association of Societies of Pathology and Laboratory Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09343
[Presentation] 肝星細胞コラーゲン産生に対するIGF-Iの調節作用およびその機序の検討2013
- Author(s)
  西川尚子, 富谷智明, 大友夏子, 井上有希子, 池田均, 白瀧博通, 小池和彦
- Organizer
  第17回日本肝臓学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] IGF-I reduces collagen production through induction of collagen degradation via mTOR dependent signaling pathway2013
- Author(s)
  西川尚子, 富谷智明, 大友夏子, 井上有希子, 池田均, 白瀧博通, 小池和彦
- Organizer
  第20回肝細胞研究会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] 肝星細胞におけるコラーゲン産生に対するIGF-Iの直接作用2012
- Author(s)
  西川尚子, 富谷智明, 大友夏子, 井上有希子, 池田均, 白瀧博通, 小池和彦
- Organizer
  第48回日本肝臓学会総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] Reduction of collagen production by insulin-like growth factor I is independent of activation state of hepatic stellate cells2012
- Author(s)
  Nishikawa T, Tomiya T, Ohtomo N, Inoue T, Ikeda H, Shirataki H, Koike K.
- Organizer
  The 63rd annual meeting of the American association for the study of liver diseases
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] 肝星細胞の増殖とコラーゲン産生に対するIGF-Iの影響に関する検討2012
- Author(s)
  西川尚子, 富谷智明, 大友夏子, 井上有希子, 池田均, 白瀧博通, 小池和彦
- Organizer
  第19回肝細胞研究会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] Insulin-like growth factor I reduces collagen production by hepatic stellate cells even when their proliferative activity is stimulated2012
- Author(s)
  Nishikawa T, Tomiya T, Ohtomo N, Inoue Y, Ikeda H, Shirataki H, Koike K
- Organizer
  22nd Conference of the Asian Pacific Association for the Study of the Liver
- Place of Presentation
  Taipei, Taiwan
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] Insulin-like growth factor I reduces collagen production by hepatic stellate cells even when their proliferative activity is stimulated.2012
- Author(s)
  Nishikawa T, Tomiya T, Ohtomo N, Inoue Y, Ikeda H, Shirataki H, Koike K.
- Organizer
  22nd Conference of the Asian Pacific Association for the Study of the Liver
- Place of Presentation
  Taipei, Taiwan
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] 肝星細胞の増殖とコラーゲン産生に対するIGF-I の影響に関する検討2012
- Author(s)
  西川尚子、富谷智明、大友夏子、井上有希子、池田均、白瀧博通、小池和彦
- Organizer
  第19回肝細胞研究会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] Reduction of collagen production by Insulin-like growth factor I is independent of modulation of activation state in hepatic stellate cells2012
- Author(s)
  Nishikawa T, Tomiya T, Ohtomo N, Inoue Y, Ikeda H, Shirataki H, Koike K
- Organizer
  63rd Annual Meeting of the American Association for the Study of the Liver Diseases
- Place of Presentation
  Boston, Massachusetts
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] 血中ADAMTS13による肝細胞癌発症予測2011
- Author(s)
  池田均, 建石良介, 榎奥健一郎, 吉田晴彦, 中川勇人, 増崎亮太, 近藤祐爾, 五藤忠, 椎名秀一朗, 富谷智明, 井上有希子, 西川尚子, 大友夏子, 田上靖, 小池和彦
- Organizer
  第47回日本肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] Effect of IGF-I and mechanisms of its action on proliferation and protein production by rat hepatocytes2011
- Author(s)
  Tanoue Y, Tomiya T, Ohtomo N, Inoue Y, Nishikawa T, Ikeda H, Shirataki H, Koike K, Fujiwara K
- Organizer
  46th Annual Meeting of the European Association for the Study of the Liver
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] 門脈圧亢進症におけるスフィンゴシン1リン酸の関与2011
- Author(s)
  池田均
- Organizer
  肝類洞壁細胞研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590716
[Presentation] 肝細胞に対するIGF-Iの作用点2011
- Author(s)
  田上靖, 富谷智明, 大友夏子, 西川尚子, 井上有希子, 池田均, 白瀧博通, 藤原研司, 小池和彦
- Organizer
  第47回日本肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] 新たな肝線維化マーカーとしての血清Autotaxin抗原量2011
- Author(s)
  中川勇人, 池田均, 増崎亮太, 建石良介, 吉田晴彦, 渡邉尚子, 富谷智明, 井上有希子, 西川尚子, 大友夏子, 田上靖, 小池和彦
- Organizer
  第47回日本肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] Effect of IGF-I and mechanisms of its action on proliferation and protein production by rat hepatocytes.2011
- Author(s)
  Tanoue Y, Tomiya T, Ohtomo N, Inoue Y, Nishikawa T, Ikeda H, Shirataki H, Koike K, Fujiwara K.
- Organizer
  46th Annual Meeting of the European Association for the Study of the Liver
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] Insulin-like growth factor I stimulates proliferation and protein production in rat hepatocytes through an mTOR signaling pathway.2010
- Author(s)
  Tanoue Y, Tomiya T, Ohtomo N, Nishikawa T, Inoue Y, Shirataki H, Ikeda H, Koike K, Fujiwara K
- Organizer
  Annual Meeting of the American Association for the Study of the Liver Diseases
- Place of Presentation
  Boston, Massachusetts
- Data Source
  KAKENHI-PROJECT-20590761
[Presentation] 受容体SIP2を介したスフィンゴシン1リン酸作用抑制による門脈圧亢進症治療の可能性2010
- Author(s)
  池田均
- Organizer
  日本肝臓学会総会
- Place of Presentation
  山形
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-22590716
[Presentation] 肝臓とレニンアンジオテンシン系メタボリックシンドロームにおける役割2010
- Author(s)
  下澤達雄、上竹勇三郎、森典子、穆勝宇、神保りか、史安男、王紅、松井宏光、小倉彩世子、池田均、矢冨裕、藤田敏郎
- Organizer
  第33回日本高血圧学会総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-20591048
[Presentation] Direct effect of insulin-like growth factor I on proliferation and protein production by rat hepatocytes.2010
- Author(s)
  Tanoue Y, Tomiya T, Ohtomo N, Inoue Y, Nishikawa T, Ikeda H, Shirataki H, Koike K, Fujiwara K
- Organizer
  FASEB Summer Research Conference : Liver Growth, Injury and Metabolism, Basic and Applied Biology
- Place of Presentation
  Snowmass, Colorado, USA
- Data Source
  KAKENHI-PROJECT-20590761
[Presentation] A role of the diet and LOX-1-induced oxidative stress in the onset of NASH.2010
- Author(s)
  Uetake Y, Shimosawa T, Ikeda H, Yatomi Y, Fujita T.
- Organizer
  14^<th> International Congress of Endocrinology(ICE2010)
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-20591048
[Presentation] A role of the diet and LOX-1-induced oxidative stress in the onset of NASH.2010
- Author(s)
  Uetake Y, Shimosawa T, Ikeda H, Yatomi Y, Fujita T.
- Organizer
  14^<th> International Congress of Endocrinology (ICE2010)
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-20591048
[Presentation] S1P2 antagonism selectively reduces portal pressure in rats with liver cirrhosis2009
- Author(s)
  Ikeda, H., Watanabe, N., Sato, Y., Nagamine, M., Yatomi, Y.
- Organizer
  4th International conference on phospholipase A2 and lipid mediators (PLM2009)
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-18209020
[Presentation] Expression of alpha-taxilin may reflect malignant potential of hepatocellular carcinoma.2009
- Author(s)
  Ohtomo N, Tomiya T, Tanoue Y, Inoue Y, Nishikawa T, Watanabe N, Ikeda H, Koike K, Seyama Y, Kokudo N, Shibahara J, Shirataki H, Fujiwara K
- Organizer
  60 th Annual Meeting of the American Association for the Study of the Liver Diseases
- Place of Presentation
  Boston, Massachusetts
- Data Source
  KAKENHI-PROJECT-20590761
[Presentation] Clinical laboratory medicine of lysophospholipid mediators2009
- Author(s)
  Yatomi, Y., Ikeda, H.
- Organizer
  4th International conference on phospholipase A2 and lipid mediators (PLM2009)
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-18209020
[Presentation] Alpha-taxilin, a postulated vesicle traffic protein, may be involved in hepatocyte proliferation.2009
- Author(s)
  Ohtomo N, Tomiya T, Tanoue Y, Inoue Y, Nishikawa T, Watanabe N, Ikeda H, Omata M, Seyama Y, Kokudo N, Shibahara J, Fukayama M, Shirataki H, Fujiwara K
- Organizer
  44 th Annual Meeting of the European Association for the Study of the Liver
- Place of Presentation
  Copenhagen, Denmark
- Data Source
  KAKENHI-PROJECT-20590761
[Presentation] Alpha-taxilin,a novel syntaxin-binding protein, is involved in cell proliferation in rat liver2008
- Author(s)
  Ohtomo N, ToMiya T, Tanoue Y,. Inoue Y, Nishikawa T, Watanabe N, Ikeda H. et al.
- Organizer
  Faseb Summer Research Conference
- Place of Presentation
  Snowmass, Colorado, USA
- Year and Date
  2008-08-05
- Data Source
  KAKENHI-PROJECT-20590761
[Presentation] A Role of the diet-induced oxidative stress in the onset of NASH.2008
- Author(s)
  Uetake Y, Shimosawa T, Ikeda H, Yutaka Y, Fujita T.
- Organizer
  43rd Annual Meeting of the European Association for the Study of the Liver (EASL)
- Place of Presentation
  Milan, Italy
- Data Source
  KAKENHI-PROJECT-20591048
[Presentation] 肝再生および線維化におけるスフィンゴシン1-リン酸(sphingosine 1-phosphate: SIP)の意義について2008
- Author(s)
  渡邉尚子、池田均ら
- Organizer
  第94回日本消化器病学会総会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2008-05-08
- Data Source
  KAKENHI-PROJECT-19590750
[Presentation] ら肝再生および線維化におけるスフィンゴシン1- リン酸(sphingosine 1-phosphate : S1P)の意義について2008
- Author(s)
  渡邉尚子、池田均
- Organizer
  第94回日本消化器病学会総会
- Place of Presentation
  福岡(国際会議場)
- Year and Date
  2008-05-08
- Data Source
  KAKENHI-PROJECT-19590750
[Presentation] Role of the diet-induced oxidative stress in the onset of NASH.2008
- Author(s)
  Uetake Y, Shimosawa T, Ikeda H. Yutaka Y. Fuiita T.
- Organizer
  43rd Annual Meeting of the European Association for the Study of the Liver (EASL)
- Place of Presentation
  Milan
- Data Source
  KAKENHI-PROJECT-20591048
[Presentation] Alpha-taxillin, a novel syntaxin-binding protein, is involved in cell proliferation in rat liver.2008
- Author(s)
  Ohtomo N, Tomiya T, Tanoue Y, Inoue Y, Nishikawa T, Watanabe N, Ikeda H, Omata M, Shirataki H, Fujiwara K
- Organizer
  FASEB Summer Research Conference : Liver Biology, Development and Disease
- Place of Presentation
  Snowmass, Colorado, USA
- Data Source
  KAKENHI-PROJECT-20590761
[Presentation] Oxygen radical production by NADPH oxidase in Kupffer cells promotes ischemic tolerance2007
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, Nishikawa T, Watanabe N, Ohtomo N, Yatomi Y, Omata M, Fujiwara K.
- Organizer
  The Asian Pacific Association for the Study of Liver Diseases
- Place of Presentation
  Kyoto, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] Sublethal oxidative stress induces hepatic ischemic tolerance via NADPH oxidase in Kupffer cells2007
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, Nishikawa T, Watanabe N, Ohtomo N, Yatomi Y, Omata M, Fujiwara K.
- Organizer
  Asian Pacific Digestive Week 2007
- Place of Presentation
  Kobe, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] Serum follistatin levels as a marker of hepato-gastrointestinal carcinomas2007
- Author(s)
  Tomiya T, Takabe K, Inoue Y, Tejima K, Ikeda H, Nishikawa T, Watanabe N, Ohtomo N, Omata M, Vale W, Fujiwara K.
- Organizer
  Asian Pacific Digestive Week 2007
- Place of Presentation
  Kobe, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] Inhibition of Rho-kinase leads to hepatocyte protection in vitro and in vivo2007
- Author(s)
  Ikeda H, Tomiya T, Tejima K, Nishikawa T, Watanabe N, Ohtomo N, Yatomi Y, Fujiwara K, Omata M.
- Organizer
  The Asian Pacific Association for the Study of Liver Diseases
- Place of Presentation
  Kyoto, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] Chemotherapy-induced HB V reactivation in an HBV carrier showing negative for HBs Ag and HBs Ab2007
- Author(s)
  Ohtomo N, Tomiya T, Sakamoto K, Yoshida H, Kato N, Tejima K, Nishikawa T, Watanabe N, Ikeda H, Omata M.
- Organizer
  The Asian Pacific Association for the Study of Liver Diseases
- Place of Presentation
  Kyoto, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] Sublethal oxidative stress induces hepatic ischemic tolerance via NADPH oxidase in Kupffer cells.2007
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, et. al.
- Organizer
  Asian Pacific Digestive Week (APDW)
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19590749
[Presentation] Pharmacological action of BCAAs on the liver : Possible contribution of BCAAs to the function of hepatic stellate cells2007
- Author(s)
  Tomiya T, Nishikawa T, Ohtomo N, Inoue Y, Tejima K, Ikeda H, Watanabe N, Tanoue Y, Omate. M, Fujiwara K.
- Organizer
  Sixth JSH Single Topic Conference
- Place of Presentation
  Iwate, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] Pharmacological action of BCAAs on the liver: Possible contribution of BCAAs to the function of hepatic stellate cells.2007
- Author(s)
  Tomiya T, Nishikawa T, Ohtomo N, moue Y, Tejima K, Ikeda H, Watanabe N, Tanoue Y, Omata M, fujiwara K.
- Organizer
  Sixth JSH Single Topic Conference
- Place of Presentation
  Iwate, Japan
- Year and Date
  2007-09-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] Induction of p53-related effector genes may regulate hepatocyte proliferation stimulated by hepatocyte growth factor2007
- Author(s)
  Inoue Y, Tomiya T, Nishikawa T, Ohtomo N, Tanoue Y, Tejima K, Ikeda H, Watanabe N, Omata M, Fujiwara K.
- Organizer
  Asian Pacific Digestive Week 2007
- Place of Presentation
  Kobe, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] Stimulatory effect of amino acids on HGF production in hepatic stellate cells2007
- Author(s)
  Nishikawa T, Tomiya T, Ohtomo N, Inoue Y, Tanoue Y, Tejima K, Ikeda H, Watanabe N, Omata M, Fujiwara K.
- Organizer
  Asian Pacific Digestive Week 2007
- Place of Presentation
  Kobe, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity2007
- Author(s)
  Watanabe N, Ikeda H, Tomiya T, Tejima K, Nishikawa T, Ohtomo N, Yatomi Y, Omta M, Fuiwara K.
- Organizer
  Asian Pacific Digestive Week 2007
- Place of Presentation
  Kobe, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] The relationship between serum follistatin levels and liver regeneration in hepatectomized patients2007
- Author(s)
  Tomiya T, Takabe K, Inoue Y, Tejima K, Ikeda H, Nishikawa T, Watanabe N, Ohtomo N, Omata M, Vale W, Fujiwara K.
- Organizer
  The Asian Pacific Association for the Study of Liver Diseases
- Place of Presentation
  Kyoto, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] Induction of P53-related effector genes may regulate hepatocyte proliferation stimulated by hepatocyte growth factor2006
- Author(s)
  Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Yanase M, Ikeda H, Tejima K, Omata M, Fujiwara K.
- Organizer
  FASEB Summer Research Conference
- Place of Presentation
  Snowmass, Colorado, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] Induction of P53-related effector genes may regulate hepatocyte proliferation stimulated by hepatocyte growth factor2006
- Author(s)
  Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Yanase M, Ikeda H, Tejima K, Omata M, Fujiwara K.
- Organizer
  FASEB Summer Research Conference
- Place of Presentation
  Colorado, USA
- Year and Date
  2006-07-24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590719

1. TOMIYA Tomoaki (90227637)

# of Collaborated Projects: 19 results

# of Collaborated Products: 90 results
2. YANASE Mikio (50334397)

# of Collaborated Projects: 10 results

# of Collaborated Products: 25 results
3. ARAI Masahiro (60271566)

# of Collaborated Projects: 9 results

# of Collaborated Products: 5 results
4. OGATA Itsuro (80169169)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
5. TEJIMA Kazuaki (30396733)

# of Collaborated Projects: 5 results

# of Collaborated Products: 42 results
6. YATOMI Yutaka (60200523)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
7. HIRATA Keiichi (50199064)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. OHNO Akihiko (30223902)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. MATSUI Atsushi (40260484)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. NAGOSHI Sumiko

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. SHIMOSAWA Tatsuo (90231365)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
12. ANDO Katsuyuki (60184313)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. YAMAOKA Miho (50261962)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MASAKI Naohiko (40219316)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MOCHIDA Sotoshi (20219968)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. FUJIWARA Kenji (80101088)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. KURANO Makoto (60621745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
18. 中川勇人 (00555609)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 山田真和 (60143426)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 岡裕爾 (20160658)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. KINOSHITA Moritoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. Uranbileg Baasanjav

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
23. 常山幸一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 矢富裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 24 results
25. 尾崎由基男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 國土典宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 石沢武彰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 青木淳賢

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

IKEDA Hitoshi 池田 均

Research Projects

Research Products

Co-Researchers

Clarification of a role of sphingosine 1-phosphate in pathology of hepatocellular carcinoma, and its application for treatment strategyPrincipal Investigator

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A novel treatment for liver injury by modulation oflipid mediator effectsPrincipal Investigator

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Elucidation of a role of sphingosine 1-phosphate on liver damagePrincipal Investigator

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Elucidation of the clinical significance of autotaxin and lysophosphatidic acid in liver diseases.Principal Investigator

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Elucidation of the mechanism of the inhibitory effect of sphingosine 1-phosphate on hepatocyte proliferation and the significance in liver regenerationPrincipal Investigator

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IKEDA Hitoshi 池田均