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SAIDO Takaomi  西道 隆臣

ORCIDConnect your ORCID iD *help
… Alternative Names

西道 隆臣  サイドウ タカオミ

SAIDO Takaomi C  西道 隆臣

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Researcher Number 80205690
External Links
Affiliation (Current) 2025: 慶應義塾大学, 医学部(信濃町), 客員教授
2025: 国立研究開発法人理化学研究所, 脳神経科学研究センター, 旧チームリーダー
Affiliation (based on the past Project Information) *help 2023 – 2024: 国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー
2017: 国立研究開発法人理化学研究所, 脳科学総合研究センター, 教授
2016: 国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー
2015: 国立研究開発法人理化学研究所, その他部局等, その他
2014: 独立行政法人理化学研究所, 脳科学総合研究センター, シニア・チームリーダー … More
2014: 独立行政法人理化学研究所, 脳科学総合研究センター, 神経蛋白制御研究チーム・チームリーダー
2013 – 2014: 独立行政法人理化学研究所, 脳科学総合研究センター, チームリーダー
2012: 独立行政法人理化学研究所, 神経蛋白制御研究チーム, シニア・チームリーダー
2008: The Institute of Physical and Chemical Research, 神経代謝機構研究グループ, グループディレクター
2007: The Institute of Physical and Chemical Research, 神経蛋白制御研究チーム, チームリーダー
2003 – 2004: 独立行政法人理化学研究所, 神経蛋白制御研究チーム, チームリーダー
2002: 理化学研究所, 神経蛋白制御研究チーム, チームリーダー
2000 – 2001: 理化学研究所, 神経蛋白制御研究チーム, チームリーダー(研究職)
1999: 理化学研究所, 脳科学総合研究センター, チームリーダー
1999: 理化学研究所, 脳科学総合研究センター, 研究員
1998: Riken Brain Science Institute, Laboratory for Proteolytic Neuroscience, Team Lea, 神経蛋白制御部門, 研究員
1997 – 1998: 理化学研究所, 神経蛋白制御研究チーム, チームリーダー(研究職)
1996 – 1997: 東京都臨床医学総合研究所, 遺伝情報部門, 研究員
1996: 東京大学, 臨床医学総合研究所, 研究員
1996: 財団法人 東京都臨床医学総合研究所, 遺伝情報研究部門, 研究員
1995 – 1996: 東京都臨床医学総合研究所, 研究員
1994 – 1996: 財団法人東京都臨床医学総合研究所, 遺伝情報研究部門, 研究員
1995: 東京都, 臨床医学総合研究所, 研究員
1992: Tokyo, Metropol. Inst. Med. Sci. Research, 遺伝情報, 研究員
1990: Tokyo Metropol. Inst. Med. Sci. Dept. Mol. Bio., researcher, 遺伝情報部門, 研究員
1988: 東京都臨床医学総合研究所, 遺伝情報研究部, 研究員 Less
Review Section/Research Field
Principal Investigator
Biological pharmacy / Biological Sciences / Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Biological pharmacy
Except Principal Investigator
物質生物化学 / Physical pharmacy / 医薬分子機能学 / Cerebral neurosurgery / Functional biochemistry / General medical chemistry / Drug development chemistry / Neurochemistry/Neuropharmacology / Dermatology
Keywords
Principal Investigator
アルツハイマー病 / カルパイン / カルパスタチン / 脳虚血 / 神経変性 / ベータアミロイド / 老化 / プロテオリシス / ALZHEIMER'S DISEASE / beta-AMYLOID … More / アミロイドβペプチド / プロテアーゼ / 神経細胞死 / 神経変性疾患 / Aβ蓄積 / トランスクリプトーム / 病態モデル / タウ病理 / brain aging / somatostatin / caspase / calpastatin / calpain / neprilysin / β amyloid / Alzheimer's disease / プロテアソーム / カイニン酸 / 中性エンドペプチダーゼ / 脳老化 / ソマトスタチン / カスパーゼ / ネプリライシン / βアミロイド / SECRETASE / PRESENILIN / セクレターゼ / プレセニリン / AGING / ISCHEMIA / FODRIN / CALPAIN / PROTEASE / PROTEOLYSIS / フオドリン / フキドリン / プロテオリミス / フォドリン / カルシウムチャネル / オリゴマー / ユビキチンンプロテアソーム / ユビキチンプロテアソーム / アポリポ蛋白質 / 代謝異常 / アミノペプチダーゼ / カルシウム / 海馬 / アクチンフィラメント / 形態形成 / 接着 / インラグリン / 上皮性ガン細胞 … More
Except Principal Investigator
カルパイン / カルシウム / calpain / ホルボ-ルエステル / プロテインキナ-ゼC / アルツハイマー病 / 構造生物学 / 神経毒性オリゴマー / アミロイドβ / 認知症 / プロテアーゼ / プロテアーゼインヒビター / プロファーゼ / EFハンド構造 / カルモジュリン / CANP / カルシウムプロテアーゼ / Aging / Degradation / Radio-label / Knockout mice / Neprilysin / Neutral Endopeptidase / Amyloid-β ptide / Alzheimers Disease / 海馬 / 大脳皮質 / プロテオリシス / ベータ-アミロイド / 老化 / 分解システム / RI標識 / ノックアウトマウス / ネプリライシン / 中性エンドペプチダーゼ / アミロイドβペプチド / calpastatin / fodrin / liposome / calpain inhibitor / cerebral ischemia / 遅発性神経細胞死 / リポソーム / カルパイン阻害剤 / 脳虚血 / MUSCULAR DYSTROPHY / HALF-LIFE / CALCIUM / PEOTEIN DEGRADATION / 筋ジストロフィー症 / 筋ジストロフィー / 寿命 / タンパク分解 / signal transduction / calcium / Protein Kinase C / ダウンレギュレ-ション / 情報伝達 / プロテインキナーゼC / phorbol ester / calcium protease / protein kinase C / カルシウムイオン / カルシウムプロテア-ゼ / MRI / NMR / 中性子捕捉療法 / グルコース / キャリア / ホウ素 / 銅 / ホウ素クラスター / グルコサミン / 天然物 / ホウ素中性子捕捉療法 / 神経発生 / ブレインバンク / タウ / アミロイド蛋白 / タウオパチー / 痴呆 / フォドリン / 神経細胞死 / 局所脳虚血 / 転換酵素 / ケラチノサイト / IL-1 Less
  • Research Projects

    (21 results)
  • Research Products

    (42 results)
  • Co-Researchers

    (44 People)
  •  How does Abeta amyloidosis promotes tau pathology in vivo?Principal Investigator

    • Principal Investigator
      西道 隆臣
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  Analyses of the oligomers of amyloid beta by NMR/MRI and protein science

    • Principal Investigator
      TERASAWA HIROAKI
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Physical pharmacy
    • Research Institution
      Kumamoto University
  •  Design and synthesis of boron-containing drugs and application to dual resonance MRI and neutron capture therapy

    • Principal Investigator
      Aoki Shin
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      Tokyo University of Science
  •  Single calcium channel(s) formed by Abeta oligomer(s)Principal Investigator

    • Principal Investigator
      SAIDO Takaomi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      The Institute of Physical and Chemical Research
  •  カルパインの脳神経系における生理機能と病理作用Principal Investigator

    • Principal Investigator
      西道 隆臣
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research
  •  The roles of proteolytic systems in brain agingPrincipal Investigator

    • Principal Investigator
      SAIDO Takaomi C.
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The Physical and Chemical Research, RIKEN
  •  Identification of the major in vivo ABl-42-degrading catabolic-system in brain parenchyma.

    • Principal Investigator
      IWATA Nobuhisa
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      医薬分子機能学
    • Research Institution
      The Institute of Physical and Chemical Research
  •  局所脳虚血におけるカルパイン-カルパスタチン系の役割の解析

    • Principal Investigator
      横田 正幸
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Hyogo Medical University
  •  アルツハイマー病発症分子機構に関する総合的研究

    • Principal Investigator
      森 啓
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Osaka City University
  •  虚血性神経細胞死におけるカルパイン-カルパスタチン系の役割の解析Principal Investigator

    • Principal Investigator
      西道 隆臣
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The Institute of Physical and Chemical Research
  •  Analysis of pathological phenotypes of familial Alzheimer's disease-associated gene mutations in presenilin.Principal Investigator

    • Principal Investigator
      SAIDO Takaomi C.
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      RIKEN Brain Science Institute
  •  虚血性神経細胞死におけるカルパイン-カルパスタチン系の役割の解析Principal Investigator

    • Principal Investigator
      西道 隆臣
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  アルツハイマー病βアミロイドペプチドのアミノ末端構造の決定と代謝に関する研究Principal Investigator

    • Principal Investigator
      西道 隆臣
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  Effects of calpain inhibitor on delayed neuronal death after global forebrain ischemia

    • Principal Investigator
      YOKOTA Masayuki
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Hyogo College of Medicine
  •  上皮性ガン細胞の増殖・接着におけるカルパイン・カルパスタチン系の役割Principal Investigator

    • Principal Investigator
      西道 隆臣
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  皮膚ケラチノサイト IL-1αの活性化および分泌機構に関する研究

    • Principal Investigator
      水谷 仁
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Mie University
  •  Determination and regulation of half-life of the proteins

    • Principal Investigator
      SUZUKI Koichi
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Functional biochemistry
    • Research Institution
      University of Tokyo
  •  Development, application, and generalization of new methodology to spatially resolve proteolytic phenomena.Principal Investigator

    • Principal Investigator
      SAIDO Takaomi C
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Biological pharmacy
    • Research Institution
      TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE
  •  Mechanism of down-regulation of protein kinase C and its implications in signal transduction

    • Principal Investigator
      SUZUKI Koichi
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      The University of Tokyo
  •  Function of Calcium-Dependent Protease in Down Regulation of Protein Dinase C

    • Principal Investigator
      SUZUKI Koichi
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      物質生物化学
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  カルシウム依存性プロテアーゼのドメイン構造と活性の発現制御

    • Principal Investigator
      鈴木 紘一
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      物質生物化学
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research

All 2024 2023 2017 2016 2015 2008 2005 2004 2000

All Journal Article Presentation Book

  • [Book] Alzheimer's Disease Research Guide: Animal Models for Understanding Mechanisms and Medications2024

    • Author(s)
      Takaomi C. Saido
    • Total Pages
      300
    • Publisher
      Elsevier
    • ISBN
      9780443289798
    • Data Source
      KAKENHI-PROJECT-23K26790
  • [Journal Article] Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer’s disease2024

    • Author(s)
      Wang Ting、Sobue Akira、Watanabe Seiji、Komine Okiru、Saido Takaomi C.、Saito Takashi、Yamanaka Koji
    • Journal Title

      Journal of Neuroinflammation

      Volume: 21 Issue: 1 Pages: 55-55

    • DOI

      10.1186/s12974-024-03046-2

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K14687, KAKENHI-PROJECT-23K06826, KAKENHI-PROJECT-20K16488, KAKENHI-PROJECT-23K26790
  • [Journal Article] Temporal Alterations in White Matter in An<i>App</i>Knock-In Mouse Model of Alzheimer’s Disease2024

    • Author(s)
      Morrissey Zachery D.、Gao Jin、Shetti Aashutosh、Li Wenping、Zhan Liang、Li Weiguo、Fortel Igor、Saido Takaomi、Saito Takashi、Ajilore Olusola、Cologna Stephanie M.、Lazarov Orly、Leow Alex D.
    • Journal Title

      eneuro

      Volume: 11 Issue: 2 Pages: 0496-23

    • DOI

      10.1523/eneuro.0496-23.2024

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K26790
  • [Journal Article] Preventive effect of propolis on cognitive decline in Alzheimer’s disease model mice.2024

    • Author(s)
      Ryo Inagaki, Tohru Yamakuni, Takashi Saito, Takaomi C Saido, Shigeki Moriguchi
    • Journal Title

      Neurobiology of Aging

      Volume: 139 Pages: 20-29

    • DOI

      10.1016/j.neurobiolaging.2024.03.002

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06794, KAKENHI-PROJECT-21K15349, KAKENHI-PROJECT-23K26790
  • [Journal Article] Effects of tooth loss on behavioral and psychological symptoms of dementia in app knock-in mice2024

    • Author(s)
      Furukawa Masae、Tada Hirobumi、Raju Resmi、Wang Jingshu、Yokoi Haruna、Yamada Mitsuyoshi、Shikama Yosuke、Saito Takashi、Saido Takaomi C.、Matsushita Kenji
    • Journal Title

      Journal of Oral Biosciences

      Volume: in press Issue: 2 Pages: 329-338

    • DOI

      10.1016/j.job.2024.03.005

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22KJ3207, KAKENHI-PROJECT-23K26790
  • [Journal Article] Sex‐dependent cholinergic effects on amyloid pathology: A translational study2023

    • Author(s)
      German‐Castelan Liliana、Shanks Hayley R. C.、Gros Robert、Saito Takashi、Saido Takaomi C.、Saksida Lisa M.、Bussey Timothy J.、Prado Marco A. M.、Schmitz Taylor W.、Prado Vania F.、the Australian Imaging Biomarkers and Lifestyle flagship study of ageing
    • Journal Title

      Alzheimer's and Dementia

      Volume: 20 Issue: 2 Pages: 995-1012

    • DOI

      10.1002/alz.13481

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K26790
  • [Journal Article] A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury2023

    • Author(s)
      Zhao Xinyi、Zeng Wen、Xu Hong、Sun Zihan、Hu Yingxin、Peng Beibei、McBride Jennifer D.、Duan Jiangtao、Deng Juan、Zhang Bin、Kim Soo-Jung、Zoll Bryan、Saito Takashi、Sasaguri Hiroki、Saido Takaomi C.、Ballatore Carlo、Yao Haishan、Wang Zhaoyin、Trojanowski John Q.、Brunden Kurt R.、Lee Virginia M.-Y.、He Zhuohao
    • Journal Title

      Science Translational Medicine

      Volume: 15 Issue: 713

    • DOI

      10.1126/scitranslmed.abo6889

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K26790
  • [Journal Article] A fully automated home cage for long-term continuous phenotyping of mouse cognition and behavior2023

    • Author(s)
      Ho Hinze、Kejzar Nejc、Sasaguri Hiroki、Saito Takashi、Saido Takaomi C.、De Strooper Bart、Bauza Marius、Krupic Julija
    • Journal Title

      Cell Reports Methods

      Volume: 3 Issue: 7 Pages: 100532-100532

    • DOI

      10.1016/j.crmeth.2023.100532

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K26790
  • [Journal Article] Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer’s disease2023

    • Author(s)
      Daniels Michael JD、Lefevre Lucas、Szymkowiak Stefan、Drake Alice、McCulloch Laura、Tzioras Makis、Barrington Jack、Dando Owen R、He Xin、Mohammad Mehreen、Sasaguri Hiroki、Saito Takashi、Saido Takaomi C、Spires-Jones Tara L、McColl Barry W
    • Journal Title

      eLife

      Volume: 12

    • DOI

      10.7554/elife.85279

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K26790
  • [Journal Article] 11B NMR Probes of Copper(II): Finding and Implications of the Cu2+-Promoted Decomposition of ortho-Carborane Deriviatives.2016

    • Author(s)
      Tomohiro Tanaka, Yukiko Nishiura, Rikita Araki, Takaomi Saido, Ryo Abe and Shin Aoki,
    • Journal Title

      European Journal of Inorganic Chemistry,

      Volume: 2016 Issue: 12 Pages: 1819-1834

    • DOI

      10.1002/ejic.201600117

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460156, KAKENHI-PROJECT-16K18915
  • [Journal Article] 11B NMR/MRI Sensing of Copper(II) Ions In Vitro by the Decomposition of a Hybrid Compound of a nido-o-Carborane and a Metal Chelator2016

    • Author(s)
      omohiro Tanaka, Rikita Araki, Takaomi Saido, Ryo Abe, and Shin Aoki
    • Journal Title

      European Journal of Inorganic Chemistry

      Volume: - Issue: 20 Pages: 3330-3337

    • DOI

      10.1002/ejic.201600346

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460156, KAKENHI-PROJECT-16K18915
  • [Journal Article] カルパスタチン遺伝子改変マウスを用いた神経変性および生理機構の解析2008

    • Author(s)
      高野 二郎、西道 隆臣
    • Journal Title

      細胞内の輪廻転生-タンパク質の分解機構(実験医学 増刊) 23

      Pages: 316-321

    • Data Source
      KAKENHI-PROJECT-19044047
  • [Journal Article] Calpain-mediated degradation of G-substrate plays a critical role in retinal excitotoxicity for amacrine cells2008

    • Author(s)
      Nakazawa, T., Shimura, M., Mourin, R., Kondo, M., Yokokura, S., Saido, T. C., Nishida, L., Endo, S.
    • Journal Title

      J. Neurosci. Res (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19044047
  • [Journal Article] Comprehensive behavioral phenotyping of calpastatin-knockout mice.2008

    • Author(s)
      Nakajima, R., Takao, K, Huang, S. M., Takano, J., Iwata, N., Miyakawa, T., Saido, T. C.
    • Journal Title

      Mol. Brain 1(7)

      Pages: 1-15

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19044047
  • [Journal Article] F- and ^1H-MRI detection of amyloid-13 peptide in vivo2005

    • Author(s)
      Higuchi M, Iwata N, Matsuba Y, Sato K, Sasamoto K, Saido TC
    • Journal Title

      Nature Neurosci. (in press)

    • Data Source
      KAKENHI-PROJECT-12210019
  • [Journal Article] Longer forms of amyloid β protein : Implications for the mechanism of intramembrane cleavage by γ-secretase2005

    • Author(s)
      Qi-Takahara Y, Morishima-Kawashima M, Tanimura Y, Dolios G, Hirotani N, Horikoshi Y. Kametani F. Maeda M. Saido TC
    • Journal Title

      J.Neurosci. 25

      Pages: 436-445

    • Data Source
      KAKENHI-PROJECT-12210019
  • [Journal Article] Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice over-expressing their specific inhibitors2005

    • Author(s)
      Higuchi M, Tomioka M, Takano J, Shirotani K, Iwata N, Masumoto H, Maki M, Itohara S. Saido TC
    • Journal Title

      J.Biol.Chem. (in press)

    • Data Source
      KAKENHI-PROJECT-12210019
  • [Journal Article] Novel α-secretase cleavage of Alzheimer's amyloid β precursor protein in the endoplasmic reticulum of CO57 cells2005

    • Author(s)
      Shin RW, Saido TC, Maeda M, Kitamoto T
    • Journal Title

      Neurosci.Lett. (in press)

    • Data Source
      KAKENHI-PROJECT-12210019
  • [Journal Article] Somatostatin regulates brain amyloid β peptide, Aβ_<42>, via modulation of proteolytic degradation Somatostatin regulates brain amyloid β peptide, Aβ_<42>, via modulation of proteolytic degradation2005

    • Author(s)
      Saito T, Iwata N, Tsubuki S, Takaki Y, Takano J, Huang S-H, Suemoto F, Higuchi M, Saido TC
    • Journal Title

      Nature Medicine (in press)

    • Data Source
      KAKENHI-PROJECT-12210019
  • [Journal Article] Fluoro-substituted and ^<13>C-labeled styrylbenzene derivatives for detecting brain amyloid plaques2004

    • Author(s)
      Sato K, Higuchi M, Iwata N, Saido TC, Sasamoto, K
    • Journal Title

      Eur.J.Medicinal.Chem. 39

      Pages: 573-578

    • Data Source
      KAKENHI-PROJECT-12210019
  • [Journal Article] Alzheimer's β-secretase cleaves a glycosyltransferase as a physiological substrate2004

    • Author(s)
      Kitazume S, Saido TC, Hashimto Y
    • Journal Title

      Glycoconjugate.J. 20

      Pages: 59-62

    • Data Source
      KAKENHI-PROJECT-12210019
  • [Journal Article] SH3 domain of spectrin participates in the activation of Rac in specialized calpain-induced integrin signaling complexes2004

    • Author(s)
      Bialkowska K, Saido TC, Fox JEB
    • Journal Title

      J.Cell.Science. 118

      Pages: 381-395

    • Data Source
      KAKENHI-PROJECT-12210019
  • [Journal Article] Truncated carboxyl-terminal fragments of β-amyloid precursor protein are processed to amyloid β-proteins 40 and 422004

    • Author(s)
      Funamoto S.Morishima-Kawashima M, Tanimura Y, Hirotani N, Saido TC, Ihara Y
    • Journal Title

      Biochemistry 43

      Pages: 13532-13540

    • Data Source
      KAKENHI-PROJECT-12210019
  • [Journal Article] Calpain activity in the Amikacin-damaged rat cochlea2004

    • Author(s)
      Ladrech, S, Guitton, M, Saido TC, Lenoir M
    • Journal Title

      J.Comp.Neurol. 477

      Pages: 149-160

    • Data Source
      KAKENHI-PROJECT-12210019
  • [Journal Article] Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid β peptide clearance in primary neurons2004

    • Author(s)
      Hama E, Shirotani K, Iwata N, Saido TC
    • Journal Title

      J.Biol.Chem. 279

      Pages: 30259-30264

    • Data Source
      KAKENHI-PROJECT-12210019
  • [Journal Article] Degradation of amyloid-β peptide : a key to Alzheimer pathogeneis, prevention, and therapy.2000

    • Author(s)
      Saido, T.C.et al.
    • Journal Title

      NeuroSci.News 5(3)

      Pages: 52-62

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12210019
  • [Journal Article] Degradation of amyloid-β peptide : a key to Alzheimer pathogeneis, prevention, and therapy.2000

    • Author(s)
      Saido, T.C.et al.
    • Journal Title

      NeuroSci. News 5

      Pages: 52-62

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-12210019
  • [Presentation] 前頭側頭葉認知症ノックインモデルマーモセット作製の提案2024

    • Author(s)
      西道隆臣
    • Organizer
      第13回 日本マーモセット研究会大会
    • Data Source
      KAKENHI-PROJECT-23K26790
  • [Presentation] Creation of next-generation animal models of FTDP-17 and AD that exhibit Abeta-independent and -dependent tau pathology without depending on an overexpression paradigm.2024

    • Author(s)
      Takaomi C. Saido
    • Organizer
      Alzheimer's Symposium: Spotlighting the Challenges and Advancements in Translational Work on Alzheimer's Disease Models
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K26790
  • [Presentation] 光架橋法と質量分析法を用いたアミロイドベータペプチド(Aβ)のオリゴマー形成メカニズムの解析2017

    • Author(s)
      川下真依, 吉田晋太郎, 吉永壮佐, 武田光広, 田中愛弓, 濱口貴史, 山口瞳, 岩本成人, 斉藤貴志, 瀧浪欣彦, 瀬田丈士, 河野俊之, 西道隆臣, 寺沢宏明
    • Organizer
      第36回日本認知症学会
    • Data Source
      KAKENHI-PROJECT-16K15110
  • [Presentation] 金属イオンによる含ホウ素化合物の分解反応の発見と金属イオン検出用11B NMR/MRIプローブへの応用2017

    • Author(s)
      青木伸、田中智博、西浦由紀子、田村佳、安部良、荒木力太、西道隆臣
    • Organizer
      第11回ホウ素・ホウ素化化合物シンポジウム(JSBB11)
    • Place of Presentation
      東京理大葛飾キャンパス(東京都・葛飾区)
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460156
  • [Presentation] Photo cross-linking and MS analyses of the amyloid β-peptide oligomers2017

    • Author(s)
      Mai Kawashita, Shintaro Yoshida, Sosuke Yoshinaga, Mitsuhiro Takeda, Ayumi Tanaka, Takashi Hamaguchi, Hitomi Yamaguchi1, Shigeto Iwamoto, Takashi Saito, Yoshihiko Takinami, Toshiyuki Kohno, Takaomi C. Saido, Hiroaki Terasawa
    • Organizer
      第55回生物物理学会
    • Data Source
      KAKENHI-PROJECT-16K15110
  • [Presentation] カルボラン分解反応を利用した銅(II)イオン検出のための11B NMR/MRIプローブの設計と合成2016

    • Author(s)
      田中 智博、西浦 由紀子、荒木 力太、西道 隆臣、安部 良、青木 伸
    • Organizer
      第42回反応と合成の進歩シンポジウム
    • Place of Presentation
      清水文化会館マリナート(静岡県・静岡市)
    • Year and Date
      2016-11-07
    • Data Source
      KAKENHI-PROJECT-26460156
  • [Presentation] Finding of deboronation reaction of ortho-carborane derivatives catalyzed by metal ions and its application to 11B NMR probes2016

    • Author(s)
      Tomohiro Tanaka, Yukiko Nishiura, Rikita Araki, Takaomi Saido, Ryo Abe, and Shin Aoki
    • Organizer
      4th International Postgraduate Conference on Pharmaceutical Sciences 2016 (iPoPS2016)
    • Place of Presentation
      Noda (東京理科大学), Chiba
    • Year and Date
      2016-02-27
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460156
  • [Presentation] ESI-QTOF MS analyses of the oligomerization mechanism of amyloid β peptides2016

    • Author(s)
      Yoshida, S., Yoshinaga, S., Takeda, M., Tanaka, A., Hamaguchi, T., Yamaguchi, H., Iwamoto, H., Saito, T., Takinami, Y., Kohno, T., Saido, T.C., and Terasawa, H.
    • Organizer
      日本生物物理学会第54回年会
    • Place of Presentation
      つくば国際会議場、茨城
    • Year and Date
      2016-11-25
    • Data Source
      KAKENHI-PROJECT-16K15110
  • [Presentation] 11B NMR/MRIによる銅イオン検出のためのキレーター導入型o-carboraneプローブの設計、合成及び反応性評価2016

    • Author(s)
      田中智博、荒木力太、西道隆臣、安部良、青木伸
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      横浜市、パシフィコ横浜
    • Year and Date
      2016-03-27
    • Data Source
      KAKENHI-PROJECT-26460156
  • [Presentation] Finding of deboronation reaction of ortho-carborane derivatives catalyzed by metal ions and its application to 11B NMR probes2015

    • Author(s)
      Tomohiro Tanaka, Yukiko Nishiura, Rikita Araki, Takaomi Saido, Ryo Abe, Shin Aoki
    • Organizer
      2015 International Chemical Congress of Pacific Basin Societies (PACICHEM2015)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460156
  • [Presentation] o-carborane分解反応に基づく金属イオン検出のための11B NMR/MRIプローブの設計、合成と反応性評価2015

    • Author(s)
      田中智博、西浦由希子、、荒木力太、西道隆臣、安部良、青木伸
    • Organizer
      日本ケミカルバイオロジー学会第10回年会
    • Place of Presentation
      仙台、東北大学
    • Year and Date
      2015-06-10
    • Data Source
      KAKENHI-PROJECT-26460156
  • [Presentation] 銅イオンによるo-carborane分解反応の発見とそれを応用した11B NMRプローブの設計と合成2015

    • Author(s)
      田中智博、西浦由希子、荒木力太、西道隆臣、安部良、青木伸
    • Organizer
      第25回金属の関与する生体関連反応シンポジウム
    • Place of Presentation
      長崎、長崎大学
    • Year and Date
      2015-05-30
    • Data Source
      KAKENHI-PROJECT-26460156
  • [Presentation] o-carborane分解反応に基づく銅イオン検出のための11B NMR/MRIプローブの設計、合成と反応性評価2015

    • Author(s)
      田中智博、西浦由希子、田村佳、荒木力太、西道隆臣、安部良、青木伸
    • Organizer
      第57回日本薬学会関東支部大会
    • Place of Presentation
      千葉、日本大学
    • Year and Date
      2015-09-12
    • Data Source
      KAKENHI-PROJECT-26460156
  • [Presentation] Regulation of Aβamyloidosis, tau phosphorylation, microgliosis and somatodendritic dystrophy by calpain-calpastatin system2008

    • Author(s)
      Saido, T. C
    • Organizer
      The 15^<th> Takeda Science Foundation Symposium on Bioscience
    • Place of Presentation
      Tokyo, Japan
    • Data Source
      KAKENHI-PROJECT-19044047
  • [Presentation] Mechanistic involvement of calpain -calpastatin system in Alzheimer pathology2008

    • Author(s)
      Saido, T. C
    • Organizer
      ICAD2008
    • Place of Presentation
      Chicago, USA
    • Data Source
      KAKENHI-PROJECT-19044047
  • 1.  YOKOTA Masayuki (40148648)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 2.  SUZUKI Koichi (80011948)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  ISHIURA Shoichi (10158743)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  OHNO Shigeo (10142027)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  AKITA Yoshiko (40124432)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  榎森 康文 (60160389)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  IWATA Nobuhisa (70246213)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 8.  Aoki Shin (00222472)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 10 results
  • 9.  HISAMATSU YOSUKE (80587270)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  TOMIOKA Shigeo (90159046)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  SORIMACHI Hiroyuki (10211327)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  MARUYAMA Kei (30211577)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  TSUBUKI Satoshi (20217368)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  TERASAWA HIROAKI (10300956)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 15.  YOSHINAGA Sosuke (00448515)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 16.  TAKEDA Mitsuhiro (90508558)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 17.  水谷 仁 (30115737)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  稲地 真 (60242939)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  山浦 生也 (50239844)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  森 啓 (10159189)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  田代 朋子 (50114541)
    # of Collaborated Projects: 1 results
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  • 22.  金井 克光 (80214427)
    # of Collaborated Projects: 1 results
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  • 23.  白澤 卓二 (80226323)
    # of Collaborated Projects: 1 results
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  • 24.  道川 誠 (40270912)
    # of Collaborated Projects: 1 results
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  • 25.  田平 武 (80112332)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  山口 晴保 (00158114)
    # of Collaborated Projects: 1 results
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  • 27.  井原 康夫 (60114386)
    # of Collaborated Projects: 1 results
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  • 28.  武田 雅俊 (00179649)
    # of Collaborated Projects: 1 results
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  • 29.  玉岡 晃 (50192183)
    # of Collaborated Projects: 1 results
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  • 30.  池田 研二 (90232181)
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  • 31.  浦上 克哉 (30213507)
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  • 32.  東海林 幹夫 (60171021)
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  • 33.  葛原 茂樹 (70111383)
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  • 34.  荒井 啓行 (30261613)
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  • 35.  安部 良 (20159453)
    # of Collaborated Projects: 1 results
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  • 36.  小野 公二 (90122407)
    # of Collaborated Projects: 1 results
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  • 37.  南 康文 (40181953)
    # of Collaborated Projects: 1 results
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  • 38.  川崎 博史 (70169704)
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  • 39.  今城 忍 (20160046)
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  • 40.  笹栗 弘貴 (10783053)
    # of Collaborated Projects: 1 results
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  • 41.  SHIBATA Masao
    # of Collaborated Projects: 1 results
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  • 42.  星 美奈子
    # of Collaborated Projects: 1 results
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  • 43.  祖父江 顕
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 44.  森口 茂樹
    # of Collaborated Projects: 0 results
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