MIZUNO Akira 水野昭

Researcher Number	80219641
External Links
Affiliation (based on the past Project Information) *help	2003 – 2006: The University of Tokushima, University Hospital, Instructor, 医学部・歯学部附属病院, 助手 2002: The University of Tokushima, Medical School Hospital, Instructor, 医学部附属病院, 助手 1999 – 2001: The Tokushima University, Medical school Hospital, Instructor, 医学部・附属病院, 助手 1998: 徳島大学, 医学部付属病院, 助手 1998: The University of Tokushima Medical School Hospital, Instructor, 医学部附属病院, 助手 … More 1996 – 1997: 徳島大学, 医学部・附属病院・検査部, 助手 1994 – 1997: 徳島大学, 医学部・附属病院, 助手 1995: 徳島大学, 医学部, 助手 1988: 徳島大学, 医学部附属病院, 助手 1988: Dept of Laboratory Medicine, Tokushima University Hospital, assistant, 附属病院検査部, 助手 1987: 徳島大学, 附属病院, 医員 1986: 徳島大学, 附属病院検査部, 医員 Less
Review Section/Research Field	Principal Investigator Laboratory medicine / Laboratory medicine Except Principal Investigator Kidney internal medicine / 内分泌・代謝学 / Metabolomics / Laboratory medicine / Kidney internal medicine
Keywords	Principal Investigator 門脈グルコースセンサー / 血小板 / インスリン抵抗性 / Impaired glucose tolerance / Obese subject / Early phase insulin response / Clamp-CPR-OGL method / Portal glucose sensor / 耐糖能障害 / 肥満者 … More / インスリン早期分泌 / Clamp-CPR-OGL法 / platelet / portal glucosensor / liver cirrhosis / diabetes mellitus / Insulin resistance / レプチン / 肝硬変 / 2型糖尿病 / insulin resistance in diabetics / hyperinsulinemic euglycemic clamp / platelet aggregation / insulin sensitivity in platelet / measurement of insulin sensitivity / 糖尿病 / polycystic ovary syndrom / 糖尿病者でのインスリン抵抗性 / 正常血糖クランプ法 / 血小板凝集 / 血小板のインスリン感受性 / インスリン感受性測定 … More Except Principal Investigator octn2 / 糖尿病 / OLETF / glomerulosclerosis / メサンギウム細胞 / インスリン抵抗性 / Smad1 / STAT3 / JVS mouse / carnitine / JVSマウス / カルニチン輸送担体 / カルニチン / mesangial cell / MSW / TGF-β / 糸球体硬化症 / microangiopathy / insulin secretion / インスリン分泌 / 膵ラ氏島 / ラ氏島 / 腹腔内脂肪 / impedance aggregometry / Prognostication of prethrombotic state / Von Willebrand因子 / フィブロネクチン / フィブリノゲン / 粘着性凝固蛋白 / 比濁法 / 全血インピーダンス法 / 血小板凝集能測定法 / hyperaggregable state / 全血血小板凝集能 / 血管機能検査 / 全血血小板凝集能(インピーダンス法) / 血栓予知 / Src / type IV collagen / angiotensin II / BMP4 / α-smooth muscle actin / diabetic nephropathy / ALK / Id2 / smad1 / AGE / SMA / ALK1 / BMP / コラーゲン / 糖尿病性腎症 / podocyte / renal failure / nephrotic syndrome / gene / kidney / 腎糸球体上皮 / ネフローゼ症候群 / 遺伝子変異 / ゲノム / ポドドサイト / ポドサイト / 腎不全 / ネフローゼ / 遺伝子 / 腎臓 / fatty acid / 2-DG uptake / glucagon / insulin / carintine transporter / 脂肪毒性 / 高血糖 / 長鎖脂肪酸 / 膵β細胞 / 脂肪酸 / 2-DG取り込み / グルカゴン / octn 2 / インスリン / vitamin K / warfarin / growth factor / Gas 6 / proliferation / Erk / 増殖抑制 / Gla化蛋白 / Axl / ビタミンK / 糸球体腎炎 / ワーファリン / 増殖因子 / Gas6 / 増殖 / diabetes mellitus / islet / 毛細血管微小血流 / 糖尿病性血管障害 / 毛細血管障害 / NaィイD1+ィエD1 dependency / pyruvate / lactate / hypoglycemia / carnitine transporter / カルニチントランスポーター / JVS マウス / β-酸化 / ポジショナルクローニング / OCTN^2 / 心筋細胞 / Na^+依存性 / ピルビン酸 / 乳酸 / 低血糖症 / promoter / transcription factor / 核転送 / プロモーター / 転写因子 / fat droplet / insulin resistance / beta-cell mass / beta-cell proliferation / Tvpe2DM / β細胞インスリン含量 / 膵管上皮細胞 / β細胞量 / 胎児ラ氏島様細胞集塊 / β細胞増殖能 / 部分膵切除 / LETO / 脂肪滴 / 細小血管症 / B細胞量 / B細胞増殖能 / 2型糖尿病 / islet B cell / glucokinase / グルコカイネース / グルコキナーゼ / Superoxide dismutase / nitric oxide / Venous occlusion test / IIIa monoclonal antibody / Anti GPIIb / Antiplatelet therapy monitoring / Einephrine-potentiated platelet aggregation / 血栓症 / 血管機能 / 血小板内カルシウム濃度 / 抗ヒトGP IIb / 血小板凝集 / 血栓-血管機能 / 一酸化窒素 / IIIaモノクローナル抗体 / 抗ヒトGPIIb / スーパーオキサイド・ジスムターゼ(SOD) / 一酸化窒素(NO) / 静脈圧迫試験 / (IIIa)モノクローナル抗体 / 抗ヒトGP(IIb) / 抗血小板療法モニタリング / 血小板エピネフリン凝集 / 糖尿病腎症 / HSP47 / IV型コラーゲン / RAGE / 糖化終末産物 / リボザイム / 食事制限 / FFA / カフェテリア食 / 視床下部破壤 / 肥満 / NIDDM Less

Fundamental Analysis of Regulation of Smadl-related Genes in Diabetic Nephropathy
- Principal Investigator
  
  ABE Hideharu
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Research Institute for Production Development
Is the disturbed early phase insulin response prescribed by the genetical role?Principal Investigator
- Principal Investigator
  
  MIZUNO Akira
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  The University of Tokushima
Molecular Pathogenesis of Hereditary Glomerulosclerosis.
- Principal Investigator
  
  TSUKAGUCHI Hiroyasu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokushima
The Study of Progressive Factors to Developing Glomerular Injury
- Principal Investigator
  
  DOI Toshio
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokushima
Is lipotoxicity caused by the intracellular accumulation ofacyl CoA ?
- Principal Investigator
  
  KUWAJIMA Masamichi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokushima
Trials for the evaluation of hepatic insulin resistance with novel simplified method using plateletPrincipal Investigator
- Principal Investigator
  
  MIZUNO Akira
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  The University of Tokushima
Hammer-head型リボザイムによる遺伝子発現抑制の腎疾患への応用
- Principal Investigator
  
  DOI Toshio
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokushima
Investigation for progressive factors of glomerulosclerosis.
- Principal Investigator
  
  DOI Toshio
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokushima
  Kyoto University
Positional cloning of carnitine transporter gene and its contribution on hypoglycemia.
- Principal Investigator
  
  KUWAJIMA Masamichi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokushima
The role of islet microangiopathy for the onset and aggravation of diabetes mellitus.
- Principal Investigator
  
  NOMA Yoshihiko
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokushima
The etiological importance of reduced B-cell masses for the development of type 2 diabetes mellitus.
- Principal Investigator
  
  SHIMA Kenji
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  The University of Tokushima
Development of simple method for a measurement of insulin sensitivity in vitro using human platelet.Principal Investigator
- Principal Investigator
  
  MIZUNO Akira
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  The University of Tokushima
The relation of gulcokinase activity and the change of the localization in islet beta cells after glucose stimulation
- Principal Investigator
  
  NOMA Yoshihiko
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  UNIVERSITY OF TOKUSHIMA
腹腔内脂肪蓄積のインスリン抵抗性への病因的関連
- Principal Investigator
  
  島健二
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  The University of Tokushima
Studies on development of vascular function test for prediction of thrombotic states
- Principal Investigator
  
  ISOBE Jun-ich
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  TOKUSHIMA UNIVERSITY
NIDDM発症予防における運動・食事療法の役割(自然発症モデルラットを用いて)
- Principal Investigator
  
  SHIMA Kenji
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  The University of Tokushima
Studies on prognostication of prethrombotic states.
- Principal Investigator
  
  ISOBE Jun-ichi
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  The University of Tokushima

All 2006

All Journal Article

[Journal Article] インスリングラルギン・グリクラジド併用療法の検討2006
- Author(s)
  水野昭
- Journal Title
  
  Diabetes Frontier (印刷中)
- Data Source
  KAKENHI-PROJECT-15590491
[Journal Article] Studies on the combination therapy of insulin glarugine and gliclazide.2006
- Author(s)
  Akira Mizuno
- Journal Title
  
  Diabetes Frontier (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590491
[Journal Article] インスリングラルギン・グリクラジド併用療法の検討2006
- Author(s)
  水野明
- Journal Title
  
  Diabetes Frontier (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590491

1. NOMA Yoshihiko (10218349)

# of Collaborated Projects: 11 results

# of Collaborated Products: 0 results
2. KUWAJIMA Masamichi (00205262)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
3. MURAKAMI Takashi (40210009)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
4. DOI Toshio (60183498)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
5. TSUKAGUCHI Hiroyasu (60335792)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. SHIMA Kenji (90028407)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. ISOBE Jun-ich (30035711)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 佐野壽昭 (80154128)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 堀内久徳 (90291426)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 久米典昭 (20252455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 横出正之 (20252447)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. ITO Michinori (40211057)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TANAKA Toshihiro (50292850)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 篠原康雄 (60226157)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 石井賢二 (00212811)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SHIMABUKURO Michio (60271144)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. ISHIMURA Kazunori (90112185)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. NAKAYA Yutaka (50136222)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. ARAI Hidekazu (60325256)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. ABE Hideharu (60399342)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. ARAI Hidenori (60232021)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

MIZUNO Akira 水野 昭

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Development of simple method for a measurement of insulin sensitivity in vitro using human platelet.Principal Investigator

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MIZUNO Akira 水野昭