KOBAYASHI Hisayoshi 小林久芳

Researcher Number	80225531
Other IDs
Affiliation (based on the past Project Information) *help	2013: 東京大学, 分子細胞生物学研究所, 助教 2007 – 2009: 東京大学, 分子細胞生物学研究所, 助教 1997 – 2006: 東京大学, 分子細胞生物学研究所, 助手
Review Section/Research Field	Principal Investigator Bioorganic chemistry Except Principal Investigator Biological Sciences / Drug development chemistry / Living organism molecular science / Chemical pharmacy
Keywords	Principal Investigator CSBP / GAZER / ZEATIN / STRUCTURE / COCONUT MILK / CYTOKININ / 糖鎖 / G3R2-ZR / ゼアチン / 構造 / ココナッツミルク / サイトカイニン … More Except Principal Investigator … More 構造展開 / サリドマイド / 構造活性相関 / 抗アンドロゲン / 酵素阻害剤 / 阻害剤 / フタルイミド / 核内受容体リガンド / レチノイド / アンドロゲン / アンタゴニスト / 腫瘍壊死因子 / 生理活性物質 / 真菌 / スクリーニング / 細胞毒性 / ホヤ / 海綿 / 海洋無脊椎生物 / 北スラウエシ州 / インドネシア / 熱帯サンゴ礁 / 調査研究 / 核内受容体 / 代謝物 / 一酸化窒素合成酵素 / シクロオキシゲナーゼ / 分子設計 / 核内レセプター / アンドロジェン / グルコシダーゼ / 耐性克服 / アンドロゲンアンタゴニスト / アミノペプチターゼ / 血管新生 / ligand / enzyme inhibitors / molecular design / structural development / androgen / thalidomide / retioids / nuclear receptor / 情報伝達物質 / 医薬品化学 / シナージスト / ホモフタルイミド / ヘシン / リガンド / 熱帯サンゴ礁海域 / 薬用海洋資源 / 変異ロドプシン / 網膜色素変性症 / ニーマン・ピック病Ｃ型 / 膜タンパク質 / 蛋白質相互作用 / マルチテンプレート / 蛋白変性症 / フォールディング異常症 / トラフィッキング / PPAR / ジフェニルペンタン / 肝臓X受容体 / 生物応答調節 / 化合部物ライブラリー / ケミカルジェネティクス / 抗ウイルス剤 / ロドプシン / 細胞内局在 / テンプレート / フォールディング / 生物応答調節剤創製法 / 医薬分子機能学 / イミダゾールアルカロイド / 北スラクエシ州 / 化学成分 / 生態 / 生理 / 海洋無脊椎動物 / ビタミンD / チュブリン重合阻害 / ヒストン脱アセチル化酵素 / 血管新生阻害 / ペプチダーゼ / 分化誘導 / チュブリン重合阻害剤 / アポトーシス / がん治療 / フェニルホモフタルイミド / フェニルフタルイミド / サブタイプ選択性 / 一酸化窒素合成酵素(NOS) / シクロオキシゲナーゼ(COX) / ヒストンデアセチラーゼ / 分化誘導促進活性 / 細胞浸潤阻害 / 前立腺がん細胞 / 医薬リード / 生物応答調節剤 / がん細胞浸潤 / 細胞検定 / シクロオキシナーゼ / 変異型レセプター / イソキサゾロン骨格 / 前立腺がん / 細胞浸潤 Less

Chemical control of protein dramatype
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Research on the marine sources for drug discovery in the tropical coral reef.
- Principal Investigator
  
  TSUKAMOTO Sachiko
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Kumamoto University
Biological response modification based on multi-template and dramatype approaches.
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Investigation of physiology, ecology, and constituents in the invertebrates, which inhabit in the coral reef of the North Pacific
- Principal Investigator
  
  TSUKAMOTO Sachiko
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Chiba University
  Kanazawa University
Development of anti-tumor agents based on biological response modification.
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
サリドマイドの抗糖尿病薬への展開
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
がん増悪因子を阻害する医薬リードの創製
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
サリドマイドの構造展開による、がん増悪因子を阻害する医薬リードの創製
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
サリドマイドの構造展開による,がん増悪因子を阻害する医薬リードの創製
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
ホルモンとしてのサリドマイド・・・細胞検定を指標にした構造展開
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokyo
Structural development of bio-active compounds affecting nuclear receptor function
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokyo
BIOLOGICAL MEANING OF MAJOR CYTOKINININ COCONUT MILK.Principal Investigator
- Principal Investigator
  
  KOBAYASHI Hisayoshi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  THE UNIVERSITY OF TOKYO

All 2011 2010 2008 2007 2006 2005

All Journal Article

[Journal Article] Isolation of salsolinol, a tetrahydroisoquinoline alkaloid, from the marine sponge Xestospongia cf. vansoesti as a proteasome inhibitor2011
- Author(s)
  Y.Nagasawa, R.E.P.Mangindaan, K.Ukai, H. Kobayashi, M.Namikoshi, S.Tsukamoto
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume: 59 Pages: 287-290
- NAID
  130000405530
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/21297314
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22406001
[Journal Article] Two unprecedented cembrene-type terpenes from an Indonesian soft coral Sarcophyton sp2010
- Author(s)
  M.Kapojos, K.Ukai, R.Mangindaan, S.Tsukamoto, H.Kobayashi, M.Namikoshi
- Journal Title
  
  Tetrahedron
  
  Volume: 66 Issue: 3 Pages: 641-645
- DOI
  10.1016/j.tet.2009.11.078
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22406001
[Journal Article] Leucettamol A : A New Inhibitor of Ubc13-Uev1A Interaction Isolated from a Marine Sponge, Leucetta aff2008
- Author(s)
  S. Tsukamoto, T. Takeuchi, H. Rotinsulu, R. E. P. Mangindaan, R. W. M. van Soest ,K. Ukai, H. Kobayashi, M. Namikoshi, T. Ohta, and H. Yokosawa
- Journal Title
  
  microrhaphis, Bioorg. Med. Chem. Lett 18(24)
  
  Pages: 6319-6320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18406002
[Journal Article] Naamidines H and I : Cytotoxic Imidazole Alkaloids from the Indonesian Marine Sponge, Leucetta chagosensis2007
- Author(s)
  S. Tsukamoto, T. Kawabata, H. Kato, T. Ohta, H. Rotinsulu, R. E. P. Mangindaan, R. W. M. van Soest, K. Ukai, H. Kobayashi and M. Namikoshi
- Journal Title
  
  J. Nat. Prod 70(10)
  
  Pages: 1658-1660
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18406002
[Journal Article] Development of tubulin-polymerization inhibitors based on thalidomide skeleton.2007
- Author(s)
  Aoyama H, Noguchi T, Misawa T, Nakamura T, Miyachi H, Hashimoto Y, Kobayashi H
- Journal Title
  
  Chem. Pharm. Bull. 55(6)
  
  Pages: 844-949
- NAID
  110006278705
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] Effects of immunomodulatory derivatives of thalidomide (IMiDs) and their analogs on cell-differentiation, cyclooxygenase activity and angiogenesis.2006
- Author(s)
  Fujimoto H, Noguchi T, Kobayashi H, Miyachi H, Hashimoto Y
- Journal Title
  
  Chem. Pharm. Bull. 54(6)
  
  Pages: 855-860
- NAID
  110004836392
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] Enhancement of all-trans retinoic acid-induced HL-60 cell differentiation by thalidomide and its metabolites.2005
- Author(s)
  T.Noguchi, C.Shinji, H.Kobayashi, 他3名
- Journal Title
  
  Biological & Pharmaceutical Bulletin 28・3
  
  Pages: 563-564
- Data Source
  KAKENHI-PROJECT-15659025
[Journal Article] Enhancement of all-trans retinoic acid-induced HL-60 cell differentiation by thalidomide and its metabolites.2005
- Author(s)
  T.Nogucchi, C.Shinji, H.Kobayashi, 他3名
- Journal Title
  
  Biological & Pharmaceutical Bulletin 28・3
  
  Pages: 563-564
- Data Source
  KAKENHI-PROJECT-17016013

1. HASHIMOTO Yuichi (90164798)

# of Collaborated Projects: 9 results

# of Collaborated Products: 2 results
2. KOISO Yuikiko (50092200)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. NOGUCHI Tomomi (20401284)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
4. NAMIKOSHI Michio (30189196)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
5. TSUKAMOTO Sachiko (40192190)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. UKAI Kazuyo (60433512)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
7. AOYAMA Hiroshi (40374699)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 長澤和夫 (10247223)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. ISHIKAWA Minoru (70526839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SUGITA Kazuyuki (60542090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MATSUMOTO Yotaro (90420041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MISAWA Takashi (40709820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 遠藤泰之 (80126002)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 森崎尚子 (00092354)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 白井隆一 (80183838)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. MANGINDAAN Remy E. P

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

KOBAYASHI Hisayoshi 小林 久芳

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BIOLOGICAL MEANING OF MAJOR CYTOKINININ COCONUT MILK.Principal Investigator

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[Journal Article] Isolation of salsolinol, a tetrahydroisoquinoline alkaloid, from the marine sponge Xestospongia cf. vansoesti as a proteasome inhibitor2011

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[Journal Article] Two unprecedented cembrene-type terpenes from an Indonesian soft coral Sarcophyton sp2010

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[Journal Article] Leucettamol A : A New Inhibitor of Ubc13-Uev1A Interaction Isolated from a Marine Sponge, Leucetta aff2008

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KOBAYASHI Hisayoshi 小林久芳