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Shimamoto Naoto  島本 直人 (鹿野 直人)

ORCIDConnect your ORCID iD *help
… Alternative Names

島本 直人 (鹿野 直人)  シマモト ナオト

鹿野直人

SHIKANO Naoto  鹿野 直人

島本 直人(鹿野直人)  シマモト ナオト

SHIMAMOTO Naoto  島本 直人

鹿野 直人  シカノ ナオト

島本 直人  シマモト ナオト

SHIKANO Noto  鹿野 直人

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Researcher Number 80295435
Other IDs
External Links
Affiliation (Current) 2025: 茨城県立医療大学, 保健医療学部, 准教授
Affiliation (based on the past Project Information) *help 2020 – 2023: 茨城県立医療大学, 保健医療学部, 准教授
2014 – 2017: 茨城県立医療大学, 保健医療学部, 准教授
2012: 茨城県立医療大学, 保健医療学部, 講師
2010 – 2011: 茨城県立医療大学, 保健医療学部・放射線技術科学科, 講師
2007: Ibaraki Prefectural University of Health Science, Department of Radiological Sciences, Assistant Professor
1998 – 2006: 茨城県立医療大学, 保健医療学部, 助手
2002: 茨城県立医療大学, 保健医療学部, 教授
Review Section/Research Field
Principal Investigator
Radiation science / Radiation science / Basic Section 52040:Radiological sciences-related
Except Principal Investigator
Radiation science / Radiation science / Basic Section 52040:Radiological sciences-related
Keywords
Principal Investigator
system L / functional imaging / neutral amino acid / 4F2hc / artificial amino acid / isoform selectivity / L-type amino acid transporter / radiopharamaceutical / 放射性医薬品 / 光学異性体 … More / BNCT / 中性子捕捉療法 / 人工アミノ酸 / 中性アミノ酸トランスポーター / pharmacokinetics / 4-borono-D-phenylalanine / 4-borono-L-phenylalanine / ホウ素アミノ酸 / アミノ酸エステル / 4-Borono-phenylalanine / ホウ素中性子捕捉療法 / BPA / 体内動態制御法 / ホウ素アミノ酸製剤 / アイソフォーム選択性 / L系 / 画像診断薬 / 機能診断薬 / アミノ酸輸送 / radiopharmaceutical / radipharamaceutical / 核医学 / グリオーマ細胞株 / フローサイトメトリー / 機能イメージング / 膜蛋白 / 放射性人工アミノ酸 / 薬物動態制御 / アミノ酸トランスポーター / リポソーム / 抗体イメージング / CD133 / 分子イメージング / 脳腫瘍 / がん幹細胞 / トランスポーターイメージング / 放射性標識抗体 / 腫瘍細胞 / 血液脳関門 / モノクロナル抗体 / ポリクリロナル抗体 / 造影剤 / CHO-K1 / system ASC / system A / 3-iodo-D-tyrosine / 中性アミノ酸輸送系 / D-アミノ酸 / X線位相撮影 / 3-iod-α-methyl-L-tyrosine / シンクロトロン放射光 / 蛍光X線CT / X線検査 / 機能造影剤 / 3-iodo-α-methyl-L-tyrosine / DLD-1 / シンクトロン放射光 / 膜輸送機能 / チロシン / 膜輪送機能 / 腎機能診断薬 / アミノ酸 … More
Except Principal Investigator
Apaf-1 / Hsp90 / アポトーシス / PI3K-Akt / 放射線増感 / 17AAG / GA / 分子イメージング / アストロサイト / 神経細胞 / 脳腫瘍細胞 / フェニルアラニンホウ素誘導体(BPA) / ホウ素中性子捕捉療法(BNCT) / C6グリオーマ細胞 / 原子吸光スペクトル / 蛍光 / BPA / ホウ素中性子捕捉療法 / 抗がん剤 / トランスポータ / 小動物イメージング / SPECT / 個別化医療 / 薬物トランスポータ / 多剤耐性 / 個別化治療 / 核医学 / apoptosis / pancreatic cell line / Sulforaphane / Rdiosensitization / Bcl-2 / apigenin / 放射線増感効果 / 生存シグナル / 膵臟がん / 膵臓がん / sulforaphane / Spheroid / Apoptosis / Radiosensitization / スフェロイド / Akt / PI3K / geldanamycin / 多細胞スフェロイド / HSP90 / Reduction of Exposure Dose / Spatial Coherence / Calcification / Small Fracture / Wooden Foreign Body / Refraction Contrast / Radiography / Synchrotron Radiation / 干渉性 / フレネル回折 / 骨画像 / 位相コントラスト / 被曝線量の軽減 / 被曝軽減 / 空間コヒーレンス / 石灰化 / 微小骨折 / 木製異物 / 屈折コントラスト / X線撮影 / シンクロトロン放射光 / 蛍光X線 / 4-Br-L-phenylalanine / 非生体構成元素 / 機能診断 / X線検査 / 人工アミノ酸 / 放射光 Less
  • Research Projects

    (15 results)
  • Research Products

    (68 results)
  • Co-Researchers

    (19 People)
  •  Development of pharmacokinetic control method using new D-BPA glycoconjugate for BNCTPrincipal Investigator

    • Principal Investigator
      島本 直人 (鹿野直人)
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Ibaraki Prefectural University of Health Science
  •  BNCT用Dフェニルアラニンホウ素誘導体の脳腫瘍モデルを用いた脳実質内分布の評価

    • Principal Investigator
      相良 順一
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Ibaraki Prefectural University of Health Science
  •  Development of methods for controlling the pharmacokinetics of boron-amino acid for BNCTPrincipal Investigator

    • Principal Investigator
      Shimamoto Naoto
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Ibaraki Prefectural University of Health Science
  •  Development of high accuracy multidrug resistance prediction method using SPECT imaging for individualized anticancer therapy

    • Principal Investigator
      KOBAYASHI Masato
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Kanazawa University
  •  Construction of strategy to develop new brain tumor imaging agents targeting cancer stem cellsPrincipal Investigator

    • Principal Investigator
      Shimamoto Naoto
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Ibaraki Prefectural University of Health Science
  •  Development of radiolabeled antibody for channel transporter imagingPrincipal Investigator

    • Principal Investigator
      SHIMAMOTO Naoto
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Ibaraki Prefectural University of Health Science
  •  Radiosensitization by inhibition of cell survival signal

    • Principal Investigator
      KUBOTA Nobuo
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Ibaraki Prefectural University of Health Science
  •  Development of isoform-specific amino acid transporter imaging agentPrincipal Investigator

    • Principal Investigator
      SHIKANO Naoto
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Radiation science
    • Research Institution
      Ibaraki Prefectural University of Health Science
  •  D-アミノ酸の組織高集積性に着目した放射性画像診断薬の開発Principal Investigator

    • Principal Investigator
      鹿野 直人
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Radiation science
    • Research Institution
      Ibaraki Prefectural University of Health Science
  •  放射光X線検査用機能診断薬の創製

    • Principal Investigator
      SHIKAWA Nobuyoshi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Radiation science
    • Research Institution
      Ibaraki Prefectural University of Health Science
  •  Radiosensitization by inhibition of Hsp90 and microenvironmental factors

    • Principal Investigator
      KUBOTA Nobuo
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Radiation science
    • Research Institution
      Ibaraki Prefectural University of Health Science
  •  Development of isoform-selective amino acid transporter imaging agentPrincipal Investigator

    • Principal Investigator
      SHIKANO Naoto
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Radiation science
    • Research Institution
      Department of Radiological Sciences Ibaraki Prefectural University of Health Sciences
  •  シンクロトロン放射光を利用したX線検査のための代謝機能診断薬の開発Principal Investigator

    • Principal Investigator
      鹿野 直人
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Radiation science
    • Research Institution
      Ibaraki Prefectural University of Health Science
  •  Development of phase sensitive radiography for human imaging by means of synchrotron radiation

    • Principal Investigator
      MORI Koichi
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      IBARAKI PREFECTURAL UNIVERSITY OF HEALTH SCIENCES
  •  腎のアミノ酸膜輸送機能の画像化を目的とした放射性機能診断薬の開発Principal Investigator

    • Principal Investigator
      鹿野 直人
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Radiation science
    • Research Institution
      Ibaraki Prefectural University of Health Science

All 2024 2023 2018 2017 2016 2015 2014 2013 2012 2011 2010 2007 2006 2004 Other

All Journal Article Presentation

  • [Journal Article] ホウ素中性子捕捉療法(BNCT)とアミノ酸 -合目的的なホウ素10の細胞特異的体内動態制御法-2024

    • Author(s)
      相澤萌夏、中島修一、相良順一、松村明、鹿野直人
    • Journal Title

      茨城県立医療大学紀要

      Volume: 29 Pages: 51-61

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K07162
  • [Journal Article] ホウ素中性子捕捉療法(BNCT)とアミノ酸 -合目的的なホウ素10の細胞特異的体内動態制御法-2024

    • Author(s)
      相澤萌夏,中島修一,相良順一,松村明,鹿野直人
    • Journal Title

      茨城県立医療大学紀要

      Volume: 29 Pages: 51-62

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K07088
  • [Journal Article] Advanced boron neutron capture therapy targeting cancer stem cells by selective induction of LAT1 overexpression.2023

    • Author(s)
      Tani T, Fujita T, Misawa M, Tojo N, Shikano N, Suzuki M, Ohnishi K.
    • Journal Title

      Radiat Res.

      Volume: 200(1) Pages: 21-31

    • DOI

      10.1667/rade-22-00195.1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K07088
  • [Journal Article] Development of radioiodine labeled acetaminophen for specific, high-contrast imaging of malignant melanoma2018

    • Author(s)
      Wen Jing Zhu , Masato Kobayashi , Kohei Yamada , Kodai Nishi , Kotaro Takahashi , Asuka Mizutani , Ryuichi Nishii , Leo G. Flores II , Naoto Shikano , Munetaka Kunishima , Keiichi Kawai
    • Journal Title

      Nuclear Medicine and Biology

      Volume: 59 Pages: 16-21

    • DOI

      10.1016/j.nucmedbio.2017.12.008

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05397, KAKENHI-PROJECT-15K09949, KAKENHI-PROJECT-18K19508
  • [Journal Article] Differences in accumulation and the transport mechanism of l- and d-methionine in high- and low-grade human glioma cells.2017

    • Author(s)
      Masato Kobayashi , Asuka Mizutani , Kodai Nishi , Syuichi Nakajima , Naoto Shikano , Ryuichi Nishii , Kazuki Fukuchi , Keiichi Kawai
    • Journal Title

      Nucl Med Biol.

      Volume: 44 Pages: 78-82

    • DOI

      10.1016/j.nucmedbio.2016.09.003

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05397, KAKENHI-PROJECT-25293260, KAKENHI-PROJECT-26461801, KAKENHI-PROJECT-15K15452, KAKENHI-PROJECT-26860988, KAKENHI-PROJECT-15K09949
  • [Journal Article] Relationship between [14C]MeAIB uptake and amino acid transporter family gene expression levels or proliferative activity in a pilot study in human carcinoma cells: Comparison with [3H]methionine uptake.2017

    • Author(s)
      Kagawa S, Nishii R, Higashi T, Yamauchi H, Ogawa E, Okudaira H, Kobayashi M, Yoshimoto M, Shikano N, Kawai K.
    • Journal Title

      Nucl Med Biol.

      Volume: 44 Pages: 8-15

    • DOI

      10.1016/j.nucmedbio.2017.01.008

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25293260, KAKENHI-PROJECT-26461801, KAKENHI-PROJECT-26461816, KAKENHI-PROJECT-15K15452, KAKENHI-PROJECT-15K09949, KAKENHI-PROJECT-17K10388, KAKENHI-PROJECT-16H05397
  • [Journal Article] Development of radioiodine-labeled 4-hydroxyphenylcysteamine for specific diagnosis of malignant melanoma.2015

    • Author(s)
      Kobayashi M, Nishii R, Shikano N, Flores LG 2nd, Mizutani A, Ogai K, Sugama J, Nagamachi S, Kawai K.
    • Journal Title

      Nucl Med Biol

      Volume: 6 Issue: 6 Pages: 536-540

    • DOI

      10.1016/j.nucmedbio.2015.02.004

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23300361, KAKENHI-PROJECT-24601008, KAKENHI-PROJECT-24659558, KAKENHI-PROJECT-26461801, KAKENHI-PROJECT-15K09949, KAKENHI-PROJECT-15K15452, KAKENHI-PROJECT-25293260
  • [Journal Article] A strategy for improving FDG accumulation for early detection of metastasis from primary pancreatic cancer: Stimulation of the Warburg effect in AsPC-1 cells.2015

    • Author(s)
      Ogura M, Shikano N, Nakajima S, Sagara J, Yamaguchi N, Kusanagi K, Okui Y, Mizutani A, Kobayashi M, Kawai K.
    • Journal Title

      Nuclear Medicine and Biology

      Volume: 42 Issue: 5 Pages: 475-481

    • DOI

      10.1016/j.nucmedbio.2014.12.017

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24601008, KAKENHI-PROJECT-24659558, KAKENHI-PROJECT-26461801, KAKENHI-PROJECT-15K09949, KAKENHI-PROJECT-15K15452, KAKENHI-PROJECT-25293260
  • [Journal Article] In vivo radioactive metabolite analysis for individualized medicine: a basic study of a new method of CYP activity assay using (123)I-IMP.2015

    • Author(s)
      Nishi K, Mizutani A, Shikano N, Fujita K, Kobayashi M, Ono M, Nishii R, Sasaki Y, Kinuya S, Kawai K.
    • Journal Title

      Nucl Med Biol

      Volume: 2 Issue: 2 Pages: 171-176

    • DOI

      10.1016/j.nucmedbio.2014.08.015

    • NAID

      120006986250

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23300361, KAKENHI-PROJECT-24601008, KAKENHI-PROJECT-24659558, KAKENHI-PROJECT-26461801, KAKENHI-PROJECT-15K15452, KAKENHI-PROJECT-26860988, KAKENHI-PROJECT-25293260
  • [Journal Article] Intracellular boron accumulation in CHO-K1 cells using amino acid transport control.2014

    • Author(s)
      Sato E, Yamamoto T, Shikano N, Ogura M, Nakai K, Yoshida F, Uemae Y, Takada T, Isobe T, Matsumura A.
    • Journal Title

      Appl Radiat Isot

      Volume: 88 Pages: 99-103

    • DOI

      10.1016/j.apradiso.2013.12.015

    • NAID

      120007136647

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26461801
  • [Journal Article] Pharmacokinetic Alteration of 99mTc-MAG3 using Serum Protein Binding Displacement Method.2013

    • Author(s)
      K Nishi, M Kobayashi, R Nishii, N Shikano, N Takamura, N Kuga, K Yamasaki, S Nagamachi, S Tamura, M Otagiri, K Kawai.
    • Journal Title

      Nucl Med Biol

      Volume: 40 Issue: 3 Pages: 366-370

    • DOI

      10.1016/j.nucmedbio.2012.12.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591372, KAKENHI-PROJECT-24601008, KAKENHI-PROJECT-24659558
  • [Journal Article] Measurement of cerebral blood flow with 99mTc-ECD SPECT and its potential clinical implications--analyzing the relationships between CBF and lifestyle disease.2013

    • Author(s)
      H Nemoto, Y Nakai, R Hatakeyama, N Shikano, S Jesmin, N Yamaguchi.
    • Journal Title

      Kaku Igaku

      Volume: 49 Pages: 329-340

    • NAID

      10031143991

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591372
  • [Journal Article] Transport mechanism of (11)C-labeled L- and D-methionine in human-derived tumor cells.2012

    • Author(s)
      M Kobayashi, F Hashimoto, K Ohe, T Nadamura, K Nishi, N Shikano, R Nishii, T Higashi, H Okazawa, K Kawai.
    • Journal Title

      Nucl Med Biol

      Volume: 39 Issue: 8 Pages: 1213-1218

    • DOI

      10.1016/j.nucmedbio.2012.06.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591372, KAKENHI-PROJECT-23300361, KAKENHI-PROJECT-24249065, KAKENHI-PROJECT-24659558
  • [Journal Article] Appropriate parameters of theordered-subset expectationmaximization algorithm on measurementof myocardial blood flow and oxygen consumption with11C-acetate PET2012

    • Author(s)
      M Kobayashi, T Mori, Y Kiyono, TTsujikawa, R Maruyama, Y Higaki, NShikano, R Nishii, K Kawai, T Kudo, Hokazawa
    • Journal Title

      NuclMed Commun

      Volume: 33 Pages: 130-138

    • Data Source
      KAKENHI-PROJECT-22591372
  • [Journal Article] Appropriate parameters of the ordered-subset expectation maximization algorithm on measurement of myocardial blood flow and oxygen consumption with 11C-acetate PET.2012

    • Author(s)
      M Kobayashi, T Mori, Y Kiyono, T Tsujikawa, R Maruyama, Y Higaki, N Shikano, R Nishii, K Kawai, T Kudo, H Okazawa.
    • Journal Title

      Nucl Med Commun

      Volume: 33 Issue: 2 Pages: 130-138

    • DOI

      10.1097/mnm.0b013e32834e7f5c

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591372, KAKENHI-PROJECT-23300361
  • [Journal Article] Appropriate parameters of the ordered-subset expectation maximization algorithm on measurement of myocardial blood flow and oxygen consumption with ^<11>C-acetate PET2012

    • Author(s)
      Kobayashi M, Mori T, Kiyono Y, Tsujikawa T, Maruyama R, Higaki Y, Shikano N, Nishii R, Kawai K, Kudo T, Okazawa H
    • Journal Title

      Nucl Med Commun

      Volume: 33 Pages: 130-138

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591372
  • [Journal Article] Putative transport mechanism andintracellular fate of anti-18F-FACBC(trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid) in human prostatecancer2011

    • Author(s)
      H Okudaira, N Shikano, R Nishii, TMiyagi, M Yoshimoto, M Kobayashi, K Ohe,T Nakanishi, I Tamai, M Namiki, K Kawai
    • Journal Title

      J Nucl Med

      Volume: 5 Pages: 2822-2829

    • Data Source
      KAKENHI-PROJECT-22591372
  • [Journal Article] Putative transport mechanism and intracellular fate of anti-^<18>F-FACBC (trans-1-amino-3-^<18>F-fluorocyclobutanecarboxylic acid) in human prostate cancer2011

    • Author(s)
      Okudaira H, Shikano N, Nishii R, Miyagi T, Yoshimoto M, Kobayashi M, Ohe K, Nakanishi T, Tamai I, Namiki M, Kawai K
    • Journal Title

      J Nucl Med

      Volume: 52 Pages: 822-829

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591372
  • [Journal Article] Radioiodinated 4-iodo-L-meta-tyrosine, a system L selective artificial amino acid : Molecular design and transport characterization in Chinese hamster ovary celis (CHO-K1 cells).2010

    • Author(s)
      鹿野直人
    • Journal Title

      Nucl Med Biol

      Volume: 37 Pages: 903-910

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591372
  • [Journal Article] Uptake of3-[125I]iodo-α-methyl-l-tyrosine intocolon cancer DLD-1 cells:characterization and inhibitoryeffect of natural amino acids and aminoacid-like drugs2010

    • Author(s)
      N Shikano, M Ogura, H Okudaira, SNakajima, T Kotani, M Kobayashi, SNakazawa, T Baba, N Yamaguchi, N Kubota, Y Iwamura, K Kawai
    • Journal Title

      Nucl Med Biol

      Volume: 37 Pages: 197-204

    • Data Source
      KAKENHI-PROJECT-22591372
  • [Journal Article] Stimulation of125I-3-iodo-alpha-methyl-L-tyrosineuptake in Chinese hamster ovary(CHO-K1) cells by tyrosine esters2010

    • Author(s)
      N Shikano, M Ogura, J Sagara, SNakajima, M Kobayashi, T Baba, NYamaguchi, Y Iwamura, N Kubota, K Kawai
    • Journal Title

      Nucl Med Biol

      Volume: 37 Pages: 189-196

    • Data Source
      KAKENHI-PROJECT-22591372
  • [Journal Article] Uptake of 3-[^<125>I]iodo-α-methyl-L-tyrosine into colon cancer DLD-1 cells : characterization and inhibitory effect of natural amino acids andamino acid-like drugs.2010

    • Author(s)
      鹿野直人
    • Journal Title

      Nucl Med Biol

      Volume: 37 Pages: 197-204

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591372
  • [Journal Article] Comparison of the transcellulartransport of FDG and D-glucose by theKidney epithelial cell line LLC-PK12010

    • Author(s)
      M Kobayashi, N Shikano, R Nishii, YKiyono, H Araki, K Nishi, M Oh, HOkudaira, M Ogura, M Yoshimoto, HOkazawa, Y Fujibayashi, K Kawai
    • Journal Title

      Nucl Med Commun

      Volume: 31 Pages: 141-146

    • Data Source
      KAKENHI-PROJECT-22591372
  • [Journal Article] Stimulation of ^<125>I-3-iodo-α-methyl-L-tyrosine uptake in Chinese hamster ovary (CHO-K1) cells by tyrosine esters.2010

    • Author(s)
      鹿野直人
    • Journal Title

      Nucl Med Biol

      Volume: 37 Pages: 189-196

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591372
  • [Journal Article] Fluorescent X-ray imaging with synchrotron radiation for the evaluation of probes for biomedical functions: A pilot study on 4-bromo-DL-phenylalanine for cancer detection in mice.2007

    • Author(s)
      N. Shikano, et. al.
    • Journal Title

      茨城県立医療大学紀要 12

      Pages: 67-73

    • NAID

      110006427212

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390336
  • [Journal Article] Recent advance in molecular pharmacological studies on radioiodinated 3-iodo-alpha-methyl-L-tyrosine, an L-type amino acid transporter 1-selective tumor imaging agent for SPECT2007

    • Author(s)
      N. Shikano
    • Journal Title

      ASVPI 12

      Pages: 1-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390336
  • [Journal Article] Transport of D-[1-14C]-amino acids into Chinese hamster ovary cells (CHO-K1): implications for use of labeled D-amino acids as molecular imaging agents.2007

    • Author(s)
      N. Shikano, et. al.
    • Journal Title

      Nucl Med Biol 34

      Pages: 659-665

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390336
  • [Journal Article] Transport of D-[1-^<14>C]-amino acids into Chinese hamster ovary cells (CHO-K1):implications for use of labeled D-amino acids as molecular imaging agents2007

    • Author(s)
      N.Shikano, et. al.
    • Journal Title

      Nucl Med Biol 34

      Pages: 659-665

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390336
  • [Journal Article] Fluorescent X-ray imaging with synchrotron radiation for the evaluation of probes for biomedical functions : A pilot study on 4-bromo-DL-phenylalanine for cancer detection in mice2007

    • Author(s)
      N. Shikano, T. Kotani, S. Nakajima, M. Ogura, K. Hyodo, H. Sugiyama, M. Monma, K. Kawai, T. Takeda, N. Kubota, K. Nishimura, K. Mori, N. Ishikawa
    • Journal Title

      ASVPI 12

      Pages: 67-73

    • NAID

      110006427212

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390336
  • [Journal Article] Pharmacokinetics of 3-[^<125>I]iodo-alpha-methyl-L-tyrosine, a tumor imaging agent, after probenecid loading in mice implanted with colon cancer DLD-1 cells2007

    • Author(s)
      S. Nakajima, N. Shikano, T. Kotani, M. Ogura, R. Nishii, M. Yoshimoto, N. Yamaguchi, Y. Iwamura, N. Kubota, N. Ishikawa, K. Kawai
    • Journal Title

      Nucl Med Biol 34

      Pages: 1003-1008

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390336
  • [Journal Article] Transport of D-[1-^<14>C]-amino acids into Chinese hamster ovary cells (CHO-K1) : implications for use of labeled D-amino acids as molecular imaging agents2007

    • Author(s)
      N. Shikano. S. Nakajima, T. Kotani, M. Ogura, J. Sagara, Y. Iwamura, M. Yoshimoto, N. Kubota, N. Ishikawa, K. Kawai
    • Journal Title

      Nucl Med Biol 34

      Pages: 659-665

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390336
  • [Journal Article] Detection of maleate-induced Fanconi syndrome by decreasing accumulation of ^<125>I-3-iodo-a-methyl-L-tyrosine in the proximal tubule segment-1 region of renal cortex in mice : a trial of separate evaluation of reabsorption2006

    • Author(s)
      N. Shikano, S. Nakajima, T. Kotani, Y. Itoh, R. Nishii, M. Yoshimoto, L.G. Flores 2nd, H. Saji, N. Ishikawa, K. Kawai
    • Journal Title

      Ann Nucl Med 20

      Pages: 175-181

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390336
  • [Journal Article] Detection of maleate-induced Fanconi syndrome by decreasing accumulation of ^<125>I-3-iodo-α-methyl-L-tyrosine in the proximal tubule segment-1 region of renal cortex in mice : a trial of separate evaluation of reabsorption.2006

    • Author(s)
      Shikano N et al.
    • Journal Title

      Ann Nucl Med 20・2(In press)

    • NAID

      10018776138

    • Data Source
      KAKENHI-PROJECT-16659322
  • [Journal Article] Presence of murine intracisternqal A particle like sequences in various animal species2006

    • Author(s)
      Okada A, Shikano N, Ohtake M, Iwamura Y
    • Journal Title

      ASVPI 11

      Pages: 65-70

    • Data Source
      KAKENHI-PROJECT-17390336
  • [Journal Article] Presence of murine intracisternal A particle-like sequences in various animal species2006

    • Author(s)
      A. Okada, N. Shikano, M. Ohtake, Y. Iwamura
    • Journal Title

      ASVPI 11

      Pages: 65-70

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390336
  • [Journal Article] Detection of maleate-induced Fanconi syndrome by decreasing accumulation of ^<125>I-3-iodo-α-methyl-L-tyrosine in the proximal tubule segment-1 region of renal cortex in mice : a trial of separate evaluation of reabsorption.2006

    • Author(s)
      Shikano N et al.
    • Journal Title

      Ann Nucl Med 20

      Pages: 175-181

    • NAID

      10018776138

    • Data Source
      KAKENHI-PROJECT-17390336
  • [Journal Article] Detection of maleate-induced Fanconi syndrome by decreasing {accumulation of ^<125>I-3-iodo-α-methyl-L-trosine in the proximal tuule segment-1 region of renal cortex in mice: atrial of separate evaluation of reabsorption2006

    • Author(s)
      Shikano N, et. al.
    • Journal Title

      Ann Nucl Med 20

      Pages: 175-181

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390336
  • [Journal Article] Detection of maleate-induced Fanconi syndrome by decreasing accumulation of ^<125>I-3-iodo-α-methyl-L-tyrosine in the proximal tubule segment-1 region of renal cortex in mice : a trial of separate evaluation of reabsorption.2006

    • Author(s)
      Shikano N et al.
    • Journal Title

      Ann Nucl Med 20・2(In press)

    • NAID

      10018776138

    • Data Source
      KAKENHI-PROJECT-17390336
  • [Journal Article] Transcellular transport of 4-iodo-L-meta-tyrosine via system L across monolayers of kidney epithelial cell line LLC-PK_1.2004

    • Author(s)
      N Shikano, K Kawai, S Nakajima, et al.
    • Journal Title

      Nucl Med Biol 31:(4)

      Pages: 477-482

    • Data Source
      KAKENHI-PROJECT-16659322
  • [Journal Article] Renal Accumulation and Excretion of Radioiodinated 3-Iodo-α-methyl-L-tyrosine.2004

    • Author(s)
      N Shikano, K Kawai, S Nakajima, R Nishii, et al.
    • Journal Title

      Ann Nucl Med 18:(3)

      Pages: 225-232

    • NAID

      10017669805

    • Data Source
      KAKENHI-PROJECT-16659322
  • [Journal Article] Renal accumulation and excretion of radioiodinated 3-iodo-methyl-L-tyrosine.2004

    • Author(s)
      N.Shikano
    • Journal Title

      Ann.Nucl.Med. 18

      Pages: 225-232

    • Data Source
      KAKENHI-PROJECT-14370283
  • [Journal Article] Transcellular transport of radioiodinated 3-iodo-α-methyl-L-tyrosine across monolayers of kidney epithelial cell line LLC-PK_1.2004

    • Author(s)
      N Shikano, K Kawai, S Nakajima, A Kubodera, et al.
    • Journal Title

      Ann Nucl Med 18:(3)

      Pages: 261-268

    • NAID

      10017669695

    • Data Source
      KAKENHI-PROJECT-16659322
  • [Journal Article] 臭素標識化合物による癌の放射光蛍光X線イメージング2004

    • Author(s)
      小谷高志, 森浩一, 中島修一, 石川演美, 鹿野直人
    • Journal Title

      第3回21世紀連合シンポジウム-科学技術と人間-抄録集 3

      Pages: 33-34

    • Data Source
      KAKENHI-PROJECT-15659283
  • [Journal Article] Radioiodinated4-iodo-L-meta-tyrosine, a system Lselective artificial amino acid:Molecular design and transportcharacterization in Chinese hamsterovary cells (CHO-K1 cells)

    • Author(s)
      N Shikano, T Kotani, S Nakajima, MOgura, S Nakazawa, J Sagara, MKobayashi, T Baba, N Yamaguchi, NKubota, K Kawai
    • Journal Title

      Nucl MedBiol

      Volume: 37 Pages: 903-910

    • Data Source
      KAKENHI-PROJECT-22591372
  • [Journal Article] Pharmacokinetic Alteration of99mTc-MAG3 using Serum Protein BindingDisplacement Method

    • Author(s)
      K Nishi, M Kobayashi, R Nishii, NShikano, N Takamura, N Kuga, K Yamasaki,S Nagamachi, S Tamura, M Otagiri, Kkawai
    • Journal Title

      Nucl Med Biol

      Volume: 40 Pages: 366-370

    • Data Source
      KAKENHI-PROJECT-22591372
  • [Journal Article] Transport mechanism of11C-labeled Land D-methionine in human-derivedtumor cells

    • Author(s)
      M Kobayashi, F Hashimoto, K Ohe, TNadamura, K Nishi, N Shikano, R Nishii,R Higashi R, H Okazawa, K Kawai
    • Journal Title

      Nucl Med Biol

      Volume: 39 Pages: 1213-1218

    • Data Source
      KAKENHI-PROJECT-22591372
  • [Presentation] Different of accumulation and transport mechanism of 11C-labeled L- and D-methionine in high and low-grade tumor cells.2016

    • Author(s)
      Kobayashi M, Mizutani A, Nishi K, Nakajima S, Shikano N, Nishii R, Kawai K.
    • Organizer
      SNMMI 2016 Annual Meeting
    • Place of Presentation
      Sandiego, USA
    • Year and Date
      2016-06-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09949
  • [Presentation] エステル封入リポソーム投与による放射性標識アミノ酸製剤の細胞内集積増大化の検討2015

    • Author(s)
      草薙健太郎,鹿野直人,小倉正人,阿部千紘,勝又幸太,菅野裕介,木村雄,對間博之,中島修一,相良順一,小林正和,川井恵一
    • Organizer
      第7回 三大学交流セミナー
    • Place of Presentation
      東京医科大学茨城医療センター(茨城県)
    • Year and Date
      2015-02-16
    • Data Source
      KAKENHI-PROJECT-26461801
  • [Presentation] LPS誘発性敗血症性腎障害へのβ1遮断薬の影響 ―腎組織の炎症系とEndothelin系からの考察―2014

    • Author(s)
      山口直人、荒井サブリナ、小倉吉保、下條信威、山木万里郎、鹿野直人、大瀬寛高、水谷太郎
    • Organizer
      第56回茨城腎研究会
    • Place of Presentation
      つくば市
    • Year and Date
      2014-06-17
    • Data Source
      KAKENHI-PROJECT-26461801
  • [Presentation] Intracellularboron accumulation in CHO-K1 cellsusing amino acid transport control2012

    • Author(s)
      E Sato, T Yamamoto, N Shikano, M Ogura,K Nakai, F Yoshida, Y Uemae, T Takada,T Isobe, A Matsumura
    • Organizer
      15th International Congress on NeutronCapture Therapy, 10 to 14 September2012 at the Tsukuba InternationalCongress Center
    • Data Source
      KAKENHI-PROJECT-22591372
  • [Presentation] Intracellular boron accumulation in CHO-K1 cells using amino acid transport control.2012

    • Author(s)
      E Sato, T Yamamoto, N Shikano, M Ogura, K Nakai, F Yoshida, Y Uemae, T Takada, T Isobe, A Matsumura
    • Organizer
      15th International Congress on Neutron Capture Therapy
    • Place of Presentation
      Tsukuba
    • Data Source
      KAKENHI-PROJECT-22591372
  • [Presentation] Transport mechanism oftrans-1-amino-3-18F-fluorocyclobutanecarboxylic acid (18F-FACBC) in humanprostate cancer2012

    • Author(s)
      H Okudaira, N Shikano, R Nishii, TMiyagi, M Yoshimoto, M Kobayashi, K Ohe,T Nakanishi, M Namiki, I Tamai, K Kawai
    • Organizer
      International Symposium on Past,Present and Future of MolecularPharmacokinatics
    • Place of Presentation
      東京
    • Year and Date
      2012-01-17
    • Data Source
      KAKENHI-PROJECT-22591372
  • [Presentation] [125I]IMT 集積増大を示すチロシンエステル曝露の細胞内誘導経路に関する検討2011

    • Author(s)
      小倉正人, 鹿野直人, 中島修一, 山口直人, 對間博之, 津田啓介, 小林正和, 川井恵一
    • Organizer
      第51回日本核医学学術総会つくば国際会議場
    • Place of Presentation
      つくば市
    • Data Source
      KAKENHI-PROJECT-22591372
  • [Presentation] [^<125>I]IMT集積増大を示すチロシンエステル曝露の細胞内誘導経路に関する検討2011

    • Author(s)
      小倉正人, 鹿野直人, 中島修一, 山口直人, 對間博之, 津田啓介, 小林正和, 川井恵一
    • Organizer
      第51回日本核医学学術総会
    • Place of Presentation
      つくば国際会議場(つくば市)
    • Year and Date
      2011-10-27
    • Data Source
      KAKENHI-PROJECT-22591372
  • [Presentation] FDG PET 検査における短時間収集での至適画像再構成法の検討2011

    • Author(s)
      津田啓介, 對間博之, 鹿野直人, 小倉正人, 鈴木天之, 戸矢和仁, 平山昭, 福士政広, 藤井博史
    • Organizer
      第51回日本核医学学術総会つくば国際会議場
    • Place of Presentation
      つくば市
    • Data Source
      KAKENHI-PROJECT-22591372
  • [Presentation] 99mTc-ECD を用いた脳血流量 SPECT 測定の臨床指標との関連性及び臨床的有用性について2010

    • Author(s)
      根本広文 畠山六郎 鹿野直人 山口直人
    • Organizer
      第50回日本核医学会学術総会
    • Place of Presentation
      大宮
    • Data Source
      KAKENHI-PROJECT-22591372
  • [Presentation] ヒト由来株化肺がん細胞 SQ-5 における3-125I-D-tyrosine の集積性に関する基礎的検討2010

    • Author(s)
      中澤伸也 鹿野直人 小倉正人 中島修一 畠山六郎 山口直人 川井恵一
    • Organizer
      ヒト由来株化肺がん細胞 SQ-5 における3-125I-D-tyrosine の集積性に関する基礎的検討
    • Place of Presentation
      大宮
    • Data Source
      KAKENHI-PROJECT-22591372
  • [Presentation] The accumulation mechanismsofanti-1-amino-3-[18F]fluorocyclobutane-1-carbocylic acid and gene expressionpatterns of amino acid transporters inhuman derived tumor cell lines2010

    • Author(s)
      K Ohe, F Takahashi, H Okudaira, SKagawa, R Nishi, N Shikano, M Kobayashi,K Kawai
    • Organizer
      2010World Molecular Imaging Congress
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-22591372
  • [Presentation] Accumulation mechanism of3-[123I]iodo-alpha-methyl-L-tyrosineusing human colon cancer DLD-1 cells2010

    • Author(s)
      T Nadamura, N Shikano, M Ogura, FTakahashi, K Ohe, M Kobayashi, K Kawai
    • Organizer
      2010 World Molecular Imaging Congress
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-22591372
  • [Presentation] Aminoacid esters could increase thetransport of artificial amino acidsinto cells by trans-stimulation2010

    • Author(s)
      M Ogura, S Nakajima, S Nakazawa, MKobayashi, N Shikano, K Kawai
    • Organizer
      2010World Molecular Imaging Congress
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-22591372
  • [Presentation] Assessment of D-[1-^<14>C]-amino acids transport using Chinese hamster ovary cells : implications for use of labeled D-amino acids as molecular imaging agents2007

    • Author(s)
      N. Shikano, N. Nakajima, T. Kotani, M. Ogura, R. Nishii, K. Nishi, M. Yoshimoto, N. Kubota, N. Ishikawa, K. Kawai
    • Organizer
      Joint Molecular Imaging Conference
    • Place of Presentation
      Providence, Rhode Island USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390336
  • [Presentation] Enzymatic activity of the 392 bp fragment from deleted mitochondrial CAN sequence2007

    • Author(s)
      K. Iwai, T. Baba, N. Shikano, S. Nakajima, M. Miyake, N.D. Parry, Y. Sakisaka, Y. Iwamura
    • Organizer
      Biochemistry and Molecular Biology 2007
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390336
  • [Presentation] Assessment of D-[1-14C]-amino acids transport using Chinese hamster ovary cells: implications for use of labeled D-amino acids as molecular imaging agents.2007

    • Author(s)
      N. Shikano, et. al.
    • Organizer
      Joint Molecular Imaging Conference
    • Place of Presentation
      Rhode Island USA
    • Data Source
      KAKENHI-PROJECT-17390336
  • [Presentation] Transport selectivity of 3-[^<123>I]iodo-alpha-methyl-L-tyrosine in human L-tupe amino acid transnorters2006

    • Author(s)
      Shikano N, et. al.
    • Organizer
      9th Congress of the World Federation of Nuclear Medicine and Biology
    • Place of Presentation
      Seoul,Korea
    • Year and Date
      2006-10-22
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390336
  • [Presentation] Membrane transport of radioiodinated 3-iodo-alpha-methyl-L-tyrosine in Chinese hamster ovary cell2006

    • Author(s)
      N. Shikano, A. Okada, S. Nakajima, T. Kotani, M. Ogura, N. Kubota, N. Ishikawa, Y. Iwamura
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390336
  • [Presentation] 標識L-Histidineの癌関連アミノ酸トランスポーターを標的とする脳腫瘍イメージング薬剤としての評価

    • Author(s)
      丹羽 隆博,坂下 真俊,西 弘大,鈴木 修斗,小林 正和,鹿野 直人,川井 恵一
    • Organizer
      第13回次世代を担う若手ファーマ・バイオフォーラム2014
    • Place of Presentation
      富山国際会議場(富山県)
    • Year and Date
      2014-09-20 – 2014-09-21
    • Data Source
      KAKENHI-PROJECT-26461801
  • [Presentation] THP-1細胞の分化過程における[125I]iodo-alpha-methyl-L-tyrosineの取り込みに関する基礎的検討

    • Author(s)
      草薙健太郎, 鹿野直人, 勝又幸太, 小倉正人, 山口直人, 對間博之, 中島修一, 下門顕太郎, 篠崎昇平, 川井恵一
    • Organizer
      第54回 日本核医学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2014-11-06 – 2014-11-08
    • Data Source
      KAKENHI-PROJECT-26461801
  • [Presentation] エステル封入リポソーム投与による放射性標識アミノ酸製剤の細胞内集積増大化の検討

    • Author(s)
      草薙健太郎,鹿野直人,小倉正人,阿部千紘,勝又幸太,菅野裕介,木村雄,對間博之,中島修一,相良順一,小林正和,川井恵一
    • Organizer
      第9回日本分子イメージング学会総会・学術集会
    • Place of Presentation
      千里ライフサイエンスセンター (大阪)
    • Year and Date
      2014-05-22 – 2014-05-23
    • Data Source
      KAKENHI-PROJECT-26461801
  • 1.  SHIKAWA Nobuyoshi (10026932)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 7 results
  • 2.  KAWAI Keiichi (30204663)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 12 results
  • 3.  KUBOTA Nobuo (20046139)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  UEHARA Tomoya (10323403)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  MORI Koichi (90274977)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  HYODO Kazuyuki (60201729)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  SATO Hitoshi (90285057)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  ANDO Masami (30013501)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  KOBAYASHI Masato (30444235)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 10.  TAMAI Ikumi (20155237)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  OKAZAWA Hidehiko (50360813)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  KUNISHIMA Munetaka (10214975)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  NISHII Ryuichi (60463212)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 14.  NISHI Kodai (10719496)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 15.  大西 健 (50152195)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  相良 順一 (50274981)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 17.  INNIS B Robert
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  NAGAMACHI Shigeki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  水谷 陽一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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