Ohguchi Kenji 大口健司

… Alternative Names

OHGUHCI Kenji 大口健司

OHGUCHI Kenji 大口健司

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Researcher Number	80359257
Other IDs
Affiliation (Current)	2025: 椙山女学園大学, 生活科学部, 教授
Affiliation (based on the past Project Information) *help	2011 – 2013: 椙山女学園大学, 生活科学部, 准教授 2006 – 2007: 財団法人岐阜県研究開発財団岐阜県国際バイオ研究所, 健康有用物質研究部, 主任研究員 2005: GIFU INTERNATIONAL INSTITUTE OF BIOTECHNOL, HEAD, 主任研究員 2005: (財)岐阜県国際バイオ研究所, 健康有用物質研究部, 主任研究員 2004: 財団法人岐阜県国際バイオ研究所, 主任研究員 2004: 財団法人岐阜県国際バイオ研究所, 健康有用物質研究部, 主任研究員 2003: GIFU INTERNATIONAL INSTITUTE OF BIOTECHNOLOGY, RESERCHER, 研究員
Review Section/Research Field	Principal Investigator Food science / Dermatology / General medical chemistry Except Principal Investigator Pathological medical chemistry / Pathological medical chemistry / Applied health science
Keywords	Principal Investigator チロシナーゼ / メラニン / ホスファチジン酸 / ホスホリパーゼD / ケラチノサイト / バリア機能 / ポリメトキシフラボン / フラボノイド / 角化 / 表皮細胞 … More / ノビレチン / 細胞機能調節物質 / 生物活性物質 / ボスホリパーゼD / 色素細胞 / mTOR / メラノジエネシス / ラパマイシン / メラノジェネシス … More Except Principal Investigator ホスホリパーゼD / 酸化ストレス / シグナル伝達 / Phospholipase D / Lipids / Oxidative stress / Signal transduction / 生存シグナリング / Pyk2キナーゼ / Aktキナーゼ / H_2O_2 / 脂質 / PHOSPHATIDYLINOSITOL 3-KINASE / AKT / PHOSPHOLIPASE D / Pyk2 / SURVAIVAL / APOPTOSIS / スフィンゴシンキナーゼ / ERK / Akt / ホスファチジルイノシトール3キナーゼ / セラミド / 生存シグナル / ホスホリバーゼD / アポトーシス / 水素 Less

Nobiletin, a polymethoxylated flavone from citrus peels, induces differentiation of normal human epidermal keratinocytesPrincipal Investigator
- Principal Investigator
  
  OHGUCHI Kenji
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Food science
- Research Institution
  Sugiyama Jogakuen University
Molecular mechanisms underlying the effects of molecular hydrogen on health promotion and disease control
- Principal Investigator
  
  ITO Masafumi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied health science
- Research Institution
  Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
  Institute of Applied Biochemistry
ホスホリパーゼD1/mTORシグナリングによるメラノジェネシス制御機構の解析Principal Investigator
- Principal Investigator
  
  大口健司
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Gifu International Institute of Biotechnology
メラノジェネシス制御シグナリングにおけるホスホリパーゼDの関与とその分子機構解析Principal Investigator
- Principal Investigator
  
  大口健司
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Gifu International Institute of Biotechnology
REGULATORY MECHANISM BY PHOSPHOLIPASE D IN OXIDANT-STRESS INDUCED SURVIVAL SIGNALING
- Principal Investigator
  
  NOZAWA Yoshinori
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  GIFU INTERNATIONAL INSTITUTE OF BIOTECHNOLOGY
CROSS-TALK OF MEMBRANE LIPID SIGNALING IN CELL DEATH AND SURVIVAL
- Principal Investigator
  
  NOZAWA Yoshinori
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  GIFU INTERNATIONAL INSTITUTE OF BIOTECHNOLOGY

All 2012 2010 2008 2007 2005 2004 Other

All Journal Article Presentation

[Journal Article] Ethanolic extracts of Brazilian red propolis increase ABCA1 expression and promote cholesterol efflux from THP-1 macrophages.2012
- Author(s)
  Iio A, Ohguchi K, Maruyama H, Tazawa S, Araki Y, Ichihara K, Nozawa Y, Ito M.
- Journal Title
  
  Phytomedicine
  
  Volume: 19 Pages: 383-388
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300244
[Journal Article] Hesperetin upregulates ABCA1 expression and promotes cholesterol efflux from THP-1 macrophages.2012
- Author(s)
  Iio A, Ohguchi K, Iinuma M, Nozawa Y, Ito M.
- Journal Title
  
  J Nat Prod
  
  Volume: 75 Pages: 563-566
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300244
[Journal Article] Hesperetin upregulates ABCA1 expression and promotes cholesterol efflux from THP-1 macrophages2012
- Author(s)
  Iio A, Ohguchi K, Iinuma M, Nozawa Y, Ito M
- Journal Title
  
  J Nat Prod
  
  Volume: 75 Issue: 4 Pages: 563-566
- DOI
  10.1021/np200696r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300244
[Journal Article] Inhibitory effects of flavonoid glycosides isolated from the peel of Japanese persimmon (Diospyros kaki 'Fuyu') on melanin biosynthesis.2010
- Author(s)
  Ohguchi K, Nakajima C, Oyama M, Iinuma M, Itoh T, Akao Y, Nozawa Y, Ito M.
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 3 Pages: 122-124
- NAID
  130000140204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300244
[Journal Article] Inhibitory effects of whisky congeners on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice.2010
- Author(s)
  Itoh T, Tsukane M, Koike M, Nakamura C, Ohguchi K, Ito M, Akao Y, Nozawa Y, Wakimoto T, Nukaya H, Suwa Y.
- Journal Title
  
  J Agrci Food Chem
  
  Volume: 58 Pages: 7149-7157
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300244
[Journal Article] Ethanolic extracts of Brazilian red propolis promote adipocyte differentiation through PPARγ activation.2010
- Author(s)
  Iio A, Ohguchi K, Inoue H, Yoko A, Nozawa Y, Ito M.
- Journal Title
  
  Phytomedicine
  
  Volume: 17 Pages: 974-979
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300244
[Journal Article] Inhibitory effects of whisky congeners on melanogenesis in mouse B16 melanoma cells2008
- Author(s)
  Ohguchi K, Koike M, Suwa Y, et. al.
- Journal Title
  
  Biosci. Biotechnol. Biochem. 72
  
  Pages: 1107-1110
- NAID
  10027526994
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790817
[Journal Article] N-trans-FeruloyltyramineasMelaninBiosynthesisinhibitor2007
- Author(s)
  Efdi M, Ohguchi K, et. al.
- Journal Title
  
  Biol Pharm Bull. 30
  
  Pages: 1972-1974
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790817
[Journal Article] Mechanism of the melanogenesis stimulation activity of(-)-cubebin in B16melanoma cells2007
- Author(s)
  Hirata N, Naruto N, OhguchiK, et. al.
- Journal Title
  
  Bloorg Med Chem. 348
  
  Pages: 398-402
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790817
[Journal Article] Negative regulation of melanogenesis by phospholipase D1 through mTOR/p70 S6 kinase 1 signaling in mouse B16 melanoma cells2005
- Author(s)
  Ohguchi, K. et al.
- Journal Title
  
  J.Cell.Physiol. 205,
  
  Pages: 444-451
- Data Source
  KAKENHI-PROJECT-16390098
[Journal Article] Negative regulation of melanogenesis by phospholipase D1 through mTOR/p70 S6 kinase 1 signaling in mouse B16 melanoma cells.2005
- Author(s)
  Ohguchi, K., et al.
- Journal Title
  
  J.Cell.Physiol. 205
  
  Pages: 444-451
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390098
[Journal Article] The negative regulation of melanogenesis by phospholipase D1 through mTOR/p70 S6 kinase 1 signaling in mouse B16 melanoma cells2005
- Author(s)
  K.Ohguchi, B.Banno, Y.Nakagawa, Y.Akao, Y.Nozawa
- Journal Title
  
  The Journal of Cellular Physiology 205
  
  Pages: 444-451
- Data Source
  KAKENHI-PROJECT-16790180
[Journal Article] Involvement of phospholipase D1 in melanogenesis of mouse B16 melanoma cell.2004
- Author(s)
  Ohguchi, K., et al.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 3408-3412
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390098
[Journal Article] Involvement of phospholipase D1 in melanogenesis of mouse B16 melanoma cell.2004
- Author(s)
  Ohguchi, K., et al.
- Journal Title
  
  J. Biol. Chem. 279
  
  Pages: 3408-3412
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390098
[Journal Article] Involvement of phospholipase D1 in melanogenesis of mouse B16 melanoma cell2004
- Author(s)
  Ohguchi, K. et al.
- Journal Title
  
  J.Blol.Chem. 279
  
  Pages: 3408-3412
- Data Source
  KAKENHI-PROJECT-16390098
[Journal Article] The negative regulation of melanogenesis by phospholipase D1 through mTOR/p70 S6 kinase 1 signaling in mouse B16 melanoma cells
- Author(s)
  K.Ohguchi, Y.Banno, Y.Nakagawa, Y.Akao, Y.Nozawa
- Journal Title
  
  The Journal of Cellular Physiology (In press)
- Data Source
  KAKENHI-PROJECT-16790180
[Journal Article] Nobiletin, a polymethoxylated flavone from citrus peels, induces differentiation of normal human epidermal keratinocytes
- Author(s)
  K. Ohguchi, M. Iinuma, Y. Nozawa, M. Ito
- Volume
  (submitted)
- Data Source
  KAKENHI-PROJECT-23580193
[Presentation] メラノジェネシスを制御する細胞内シグナル伝達機構2007
- Author(s)
  大口健司
- Organizer
  第6回ホスファチジルセリン研究会
- Place of Presentation
  東京
- Year and Date
  2007-11-19
- Data Source
  KAKENHI-PROJECT-18790817

1. NOZAWA Yoshinori (10021362)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. BANNO Yoshiko (50116852)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. AKAO Yukihiro (00222505)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. ITO Masafumi (80393114)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
5. OHNO Kinji (80397455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. FUJITA Yasunori (30515888)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. ITOH Tomohiro (30435854)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. IIO Akio (80344349)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. ITO Mikako (60444402)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
10. TANAKA Masashi (60155166)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NAKAGAWA Yoshihito (60372108)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 吉田均 (30303548)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 松本健司 (60288701)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 飯尾明夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

Ohguchi Kenji 大口 健司

OHGUHCI Kenji 大口 健司

OHGUCHI Kenji 大口 健司

Research Projects

Research Products

Co-Researchers

Nobiletin, a polymethoxylated flavone from citrus peels, induces differentiation of normal human epidermal keratinocytesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms underlying the effects of molecular hydrogen on health promotion and disease control

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ホスホリパーゼD1/mTORシグナリングによるメラノジェネシス制御機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

メラノジェネシス制御シグナリングにおけるホスホリパーゼDの関与とその分子機構解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

REGULATORY MECHANISM BY PHOSPHOLIPASE D IN OXIDANT-STRESS INDUCED SURVIVAL SIGNALING

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

CROSS-TALK OF MEMBRANE LIPID SIGNALING IN CELL DEATH AND SURVIVAL

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Ethanolic extracts of Brazilian red propolis increase ABCA1 expression and promote cholesterol efflux from THP-1 macrophages.2012

Author(s)

Journal Title

Data Source

[Journal Article] Hesperetin upregulates ABCA1 expression and promotes cholesterol efflux from THP-1 macrophages.2012

Author(s)

Journal Title

Data Source

[Journal Article] Hesperetin upregulates ABCA1 expression and promotes cholesterol efflux from THP-1 macrophages2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibitory effects of flavonoid glycosides isolated from the peel of Japanese persimmon (Diospyros kaki 'Fuyu') on melanin biosynthesis.2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Inhibitory effects of whisky congeners on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice.2010

Author(s)

Journal Title

Data Source

[Journal Article] Ethanolic extracts of Brazilian red propolis promote adipocyte differentiation through PPARγ activation.2010

Author(s)

Journal Title

Data Source

[Journal Article] Inhibitory effects of whisky congeners on melanogenesis in mouse B16 melanoma cells2008

Author(s)

Journal Title

NAID

Data Source

[Journal Article] N-trans-FeruloyltyramineasMelaninBiosynthesisinhibitor2007

Author(s)

Journal Title

Data Source

[Journal Article] Mechanism of the melanogenesis stimulation activity of(-)-cubebin in B16melanoma cells2007

Author(s)

Journal Title

Ohguchi Kenji 大口健司

OHGUHCI Kenji 大口健司

OHGUCHI Kenji 大口健司