Ki Hin 季斌

… Alternative Names

JI Bin 季斌

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Researcher Number	80392223
Other IDs	https://orcid.org/0000-0002-9672-6441
Affiliation (Current)	2025: 国立研究開発法人国立長寿医療研究センター, 研究所認知症先進医療開発センター, 客員研究員
Affiliation (based on the past Project Information) *help	2022 – 2023: 国立研究開発法人国立長寿医療研究センター, 研究所認知症先進医療開発センター, 客員研究員 2021: 国立研究開発法人国立長寿医療研究センター, 認知症先進医療開発センター, 客員研究員 2016 – 2020: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所脳機能イメージング研究部, 主任研究員(任常) 2017: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所・脳機能イメージング研究部, 主任研究員 2016: 量子科学技術研究開発機構, 放射線医学総合研究所・脳機能イメージング研究部, 主任研究員 … More 2015: 国立研究開発法人放射線医学総合研究所, 分子イメージング研究センター, 主任研究員 2008 – 2011: National Institute of Radiological Sciences, 分子イメージング研究センター, 主任研究員 2007: National Institute of Radiological Sciences, 分子イメージング研究センター, 主任研究員 Less
Review Section/Research Field	Principal Investigator Neurology / Basic Section 52040:Radiological sciences-related / Radiation science Except Principal Investigator Basic Section 52040:Radiological sciences-related / Radiation science / Basic / Social brain science / Biological Sciences
Keywords	Principal Investigator PET / 神経炎症 / ミクログリア / アルツハイマー病 / TSPO / Gila / 11C-CPPC / 11C-GW2580 / 神経炎症イメージング / CSF1R … More / Translocator Protein / inflammation / 分子イメージング / アミロイド / CCr2 / Alzheimer's disease / TSPO ligand / MCP-1 / 末梢性ベンゾジアゼピン受容体イメージング / アミロイドイメージング / Alzheimer病 / Glia / PBR ligand / PBR / Alzheimer … More Except Principal Investigator PET / ミクログリア / アルツハイマー病 / 陽電子断層撮像法 / CSF1R / Alzheimer's disease / microglia / RIPK1 / 神経炎症 / マイクログリア / 陽電子断層撮像 / ドーパミン / 糖代謝 / 覚醒下 / グルコース代謝 / SPECT / 脳血流 / DREADD / 遺伝子 / 霊長類 / 脳・神経 / 化学遺伝学 / サル / イメージング / 神経原線維変化 / 老人斑 / タウ蛋白 / アミロイドβペプチド / ポジトロン断層撮影 / 脳アミロイド Less

Development of PET imaging of brain immunity as a biomarker for drug development to treat neurodegenerative diseases
- Principal Investigator
  
  KIMURA YASUYUKI
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Center for Geriatrics and Gerontology
Targeting CSF1R as imaging biomarker of microgliaPrincipal Investigator
- Principal Investigator
  
  季斌
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
PET imaging of microglia, a novel drug target for neurodegenerative diseases
- Principal Investigator
  
  Kimura Yasuyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Center for Geriatrics and Gerontology
Development of next-generation PET ligand for neuroinflammation and comparison with current ligandsPrincipal Investigator
- Principal Investigator
  
  JI BIN
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
In vivo neural projection mapping technology with a novel PET ligand
- Principal Investigator
  
  Minamimoto Takafumi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Basic / Social brain science
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
In vivo brain activity imaging in DREADD expressed animals
- Principal Investigator
  
  SEKI Chie
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
The role of neuroinflammation and responsible molecules in Alzheimer's disease onsetPrincipal Investigator
- Principal Investigator
  
  JI Bin
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  National Institute of Radiological Sciences
アミロイドカスケードのキープロセス可視化によるアルツハイマー病の診断・治療法開発
- Principal Investigator
  
  HIGUCHI Makoto
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Radiological Sciences
Research on the Role of Glial Cells in Alzheimer's Diseases-Using Molecular Imaging techniquesPrincipal Investigator
- Principal Investigator
  
  JI Bin
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  National Institute of Radiological Sciences

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2012 2011 2010 2009 2008 2007

All Journal Article Presentation

[Journal Article] Synthesis and evaluation of a novel PET ligand, a GSK’963 analog, aiming at autoradiography and imaging of the receptor interacting protein kinase 1 in the brain2023
- Author(s)
  Ikenuma Hiroshi、Ogata Aya、Koyama Hiroko、Ji Bin、Ishii Hideki、Yamada Takashi、Abe Junichiro、Seki Chie、Nagai Yuji、Ichise Masanori、Minamimoto Takafumi、Higuchi Makoto、Zhang Ming-Rong、Kato Takashi、Ito Kengo、Suzuki Masaaki、Kimura Yasuyuki
- Journal Title
  
  EJNMMI Radiopharmacy and Chemistry
  
  Volume: 8 Issue: 1 Pages: 31-31
- DOI
  10.1186/s41181-023-00217-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02876, KAKENHI-PROJECT-23K27558
[Journal Article] Development of a novel PET ligand, [11C]GO289 targeting CK2 expressed in the brain2023
- Author(s)
  Ogata Aya、Yamada Takashi、Hattori Saori、Ikenuma Hiroshi、Abe Junichiro、Tada Mari、Ichise Masanori、Suzuki Masaaki、Ito Kengo、Kato Takashi、Amaike Kazuma、Hirota Tsuyoshi、Kakita Akiyoshi、Itami Kenichiro、Kimura Yasuyuki
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 90 Pages: 129327-129327
- DOI
  10.1016/j.bmcl.2023.129327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21269, KAKENHI-PROJECT-21H02876
[Journal Article] [11C]NCGG401, a novel PET ligand for imaging of colony stimulating factor 1 receptors2022
- Author(s)
  Ogata Aya、Ji Bin、Yamada Takashi、Hattori Saori、Abe Junichiro、Ikenuma Hiroshi、Ichise Masanori、Koyama Hiroko、Suzuki Masaaki、Kato Takashi、Ito Kengo、Kimura Yasuyuki
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 65 Pages: 128704-128704
- DOI
  10.1016/j.bmcl.2022.128704
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02876
[Journal Article] Detection of Alzheimer’s disease-related neuroinflammation by a PET ligand selective for glial versus vascular translocator protein2021
- Author(s)
  Ji Bin、Ono Maiko、Yamasaki Tomoteru、Fujinaga Masayuki、Zhang Ming-Rong、Seki Chie、Aoki Ichio、Kito Seiji、Sawada Makoto、Suhara Tetsuya、Sahara Naruhiko、Higuchi Makoto
- Journal Title
  
  Journal of Cerebral Blood Flow & Metabolism
  
  Volume: - Issue: 8 Pages: 1-14
- DOI
  10.1177/0271678x21992457
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06896, KAKENHI-PLANNED-18H05429, KAKENHI-PUBLICLY-19H05437, KAKENHI-PROJECT-19K08137
[Journal Article] PET imaging of colony-stimulating factor 1 receptor: A head-to-head comparison of a novel radioligand, 11C-GW2580, and 11C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey2021
- Author(s)
  Zhou Xiaoyun、Ji Bin、Seki Chie、Nagai Yuji、Minamimoto Takafumi、Fujinaga Masayuki、Zhang Ming-Rong、Saito Takashi、Saido Takaomi C、Suhara Tetsuya、Kimura Yasuyuki、Higuchi Makoto
- Journal Title
  
  Journal of Cerebral Blood Flow & Metabolism
  
  Volume: 0 Issue: 9 Pages: 1-13
- DOI
  10.1177/0271678x211004146
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16274, KAKENHI-PROJECT-19K08137
[Journal Article] In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg45102018
- Author(s)
  Ishikawa Ai、Tokunaga Masaki、Maeda Jun、Minamihisamatsu Takeharu、Shimojo Masafumi、Takuwa Hiroyuki、Ono Maiko、Ni Ruiqing、Hirano Shigeki、Kuwabara Satoshi、Ji Bin、Zhang Ming-Rong、Aoki Ichio、Suhara Tetsuya、Higuchi Makoto、Sahara Naruhiko
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 61 Issue: 3 Pages: 1037-1052
- DOI
  10.3233/jad-170509
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10387, KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-15K06793, KAKENHI-PROJECT-15K09979, KAKENHI-PROJECT-16K21636, KAKENHI-PROJECT-16K19872
[Journal Article] Comparative in-vitro quantification of pathological tau deposits and their association with neurodegeneration in tauopathy mouse models2018
- Author(s)
  Ni R, Ji B, Ono M, Sahara N, Zhang M-R, Aoki I, Nordberg A, Suhara T, Higuchi M
- Journal Title
  
  J. Nuclear Medicine
  
  Volume: 117 Issue: 6 Pages: 960-966
- DOI
  10.2967/jnumed.117.201632
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-15K06793, KAKENHI-PROJECT-15K09979, KAKENHI-PROJECT-16K19872
[Journal Article] Steroidogenic abnormalities in translocator protein knockout mice and significance in the aging male2017
- Author(s)
  Barron Anna M.、Ji Bin、Kito Seiji、Suhara Tetsuya、Higuchi Makoto
- Journal Title
  
  Biochemical Journal
  
  Volume: 475 Issue: 1 Pages: 75-85
- DOI
  10.1042/bcj20170645
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-15K09979
[Journal Article] Distinct binding of two PET ligands, PBB3 and AV-1451, to tau fibril strains in Alzheimer’s disease and related neurodegenerative tauopathy disorders.2017
- Author(s)
  71.Ono M, Sahara N, Kumata K, Ji B, Ni R, Dickson DW, Trojanowski JQ, Lee VM-Y, Yoshida M, Hozumi I, Yoshiyama Y, Nordberg A, Suhara T, Zhang M-R, Higuchi M.
- Journal Title
  
  Brain
  
  Volume: 140 Pages: 764-780
- DOI
  10.1093/brain/aww339
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-15K06793, KAKENHI-PROJECT-15K09979
[Journal Article] Assessment of neuroinflammation in a mouse model of obesity and β-amyloidosis using PET2016
- Author(s)
  Anna Barron, Masaki Tokunaga, Ming-Rong Zhang, Bin Ji, Tetsuya Suhara, Makoto Higuchi
- Journal Title
  
  Journal of neuroinflammation
  
  Volume: 13 Pages: 221-221
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09979
[Journal Article] In vivo imaging of neuroinflammation in Alzheimer's disease2016
- Author(s)
  Makoto Higuchi, Bin Ji, Jun Maeda, Naruhiko Sahara and Tetsuya Suhara
- Journal Title
  
  Clinical and Experimental Neuroimmunology
  
  Volume: unsettled Issue: 2 Pages: 139-144
- DOI
  10.1111/cen3.12308
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09979, KAKENHI-PROJECT-15K06793
[Journal Article] DREADD-expressing neurons in living brain and their application to implantation of iPSC-derived neuroprogenitors.2016
- Author(s)
  Ji B, Kaneko H, Minamimoto T, Inoue H, Takeuchi H, Kumata K, Zhang MR, Aoki I, Seki C, Ono M, Tokunaga M, Tsukamoto S, Tanabe K, Shin RM, Minamihisamatsu T, Kito S, Richmond BJ, Suhara T, Higuchi M.
- Journal Title
  
  J. Neuroscience
  
  Volume: 36 Issue: 45 Pages: 11544-11558
- DOI
  10.1523/jneurosci.1279-16.2016
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05917, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-26282221, KAKENHI-PROJECT-15K12772, KAKENHI-PLANNED-25111005
[Journal Article] 神経炎症イメージング用放射標識リガンドの開発の現状と展望2016
- Author(s)
  季　斌, 樋口　真人, 須原　哲也
- Journal Title
  
  老年精神医学雑誌
  
  Volume: 27 Pages: 977-983
- Data Source
  KAKENHI-PROJECT-15K09979
[Journal Article] タウ・炎症と神経変性2016
- Author(s)
  樋口　真人、須原　哲也、季　斌
- Journal Title
  
  医学の歩み第５土曜特集アルツハイマー病UPDATE
  
  Volume: 257 Pages: 381-7
- Data Source
  KAKENHI-PROJECT-15K09979
[Journal Article] PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation.2016
- Author(s)
  Nagai Y, Kikuchi E, Lerchner W, Inoue Ki, Ji B, Eldridge MA, Kaneko H, Kimura Y, Oh-Nishi A, Hori Y, Kato Y, Hirabayashi T, Fujimoto A, Kumata K, Zhang MR, Aoki I, SuharaT, Higuchi M, Takada M, Richmond BJ, Minamimoto T.
- Journal Title
  
  Nature Communications
  
  Volume: 7 Issue: 1 Pages: 13605-13605
- DOI
  10.1038/ncomms13605
- NAID
  120005898960
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01419, KAKENHI-PUBLICLY-15H01431, KAKENHI-PUBLICLY-15H01434, KAKENHI-PLANNED-15H05917, KAKENHI-PUBLICLY-16H01611, KAKENHI-PROJECT-16H02454, KAKENHI-PROJECT-15H06872, KAKENHI-PROJECT-26282221, KAKENHI-PROJECT-15K12772, KAKENHI-PROJECT-15K14316, KAKENHI-PROJECT-16KT0193
[Journal Article] Distinct binding of amyloid imaging ligands to unique amyloid-β deposited in the presubiculum of Alzheimer's disease2015
- Author(s)
  Ji B, Chen CJ, Bando K, Ashino H, Shiraishi H, Sano H, Kasahara H, Minamizawa T, Yamada K, Ono M, Zhang MR, Seki C, Farde L, Suhara T, Higuchi M
- Journal Title
  
  J Neurochem
  
  Volume: 135 Issue: 5 Pages: 859-66
- DOI
  10.1111/jnc.13293
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09979, KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235
[Journal Article] [18F]FEBMP: Positron Emission Tomography Imaging of TSPO in a Model of Neuroinflammation in Rats, and in vitro Autoradiograms of the Human Brain2015
- Author(s)
  Tiwari AK, Ji B, Yui J, Fujinaga M, Yamasaki T, Xie L, Luo R, Shimoda Y, Kumata K, Zhang Y, Hatori A, Maeda J, Higuchi M, Wang F, Zhang MR.
- Journal Title
  
  Theranostics
  
  Volume: 26 Issue: 9 Pages: 961-9
- DOI
  10.7150/thno.12027
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09979, KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235
[Journal Article] Brain-targeted co-delivery of therapeutic gene and peptide by multifunctional nanoparticles in Alzheimer's disease mice2015
- Author(s)
  Liu Y, An S, Li J, Kuang Y, He X, Guo Y, Ma H, Zhang Y, Ji B, Jiang C.
- Journal Title
  
  Biomaterials
  
  Volume: 88 Issue: 1 Pages: 33-45
- DOI
  10.1038/nn.4192
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09979, KAKENHI-PLANNED-15H05917
[Journal Article] An Alteration in the Lateral Geniculate Nucleus of Experimental Glaucoma Monkeys : In vivo Positron Emission Tomography Imaging of Glial Activation2012
- Author(s)
  Shimazawa M, Ito Y, Inokuchi Y, Yamanaka H, Nakanishi T Hayashi T, Bin Ji, Higuchi M, Suhara T, Imamura K, Araie M, Watanabe Y, Onoe H, Hara H
- Journal Title
  
  PLoS One
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790835
[Journal Article] PET Applications in Animal Models of Neurodegenerative and Neuroinflammatory Disorders2012
- Author(s)
  Higuchi M, Maeda J, Ji B, Tokunaga M, Zhang MR, Maruyama M, Ono M, Fukumura T, Suhara T
- Journal Title
  
  Curr Top Behav Neurosci
  
  Volume: 11 Pages: 45-64
- DOI
  10.1007/7854_2011_167
- ISBN
  9783642287107, 9783642287114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590053, KAKENHI-PROJECT-22790835, KAKENHI-PROJECT-23390235, KAKENHI-PLANNED-23111009
[Journal Article] An alteration in the lateral geniculate nucleus of experimental glaucoma monkeys : in vivo positron emission tomography imaging of glial activation2012
- Author(s)
  Shimazawa, M., Ito, Y., Inokuchi, Y., Yamanaka, H., Nakanishi, T., Hayashi, T., Ji, B., Higuchi, M., Suhara, T., Imamura, K., Araie, M., Watanabe, Y., Onoe, H., and Hara, H.
- Journal Title
  
  PLoS One
  
  Volume: 7
- Data Source
  KAKENHI-PROJECT-22790835
[Journal Article] Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology2012
- Author(s)
  Higuchi M, Iwata N, Matsuba Y, Takano J, Suemoto T, Maeda J, Ji B, Ono M, Staufenbiel M, Suhara T, Saido TC
- Journal Title
  
  FASEB J
  
  Volume: 26(3) Issue: 3 Pages: 1204-1217
- DOI
  10.1096/fj.11-187740
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590053, KAKENHI-PROJECT-22790835, KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235
[Journal Article] 認知症の分子イメージング2011
- Author(s)
  須原哲也, 樋口真人, 前田純, 季斌
- Journal Title
  
  生物学的精神医学会誌
  
  Volume: 21 Pages: 261-266
- NAID
  10029785231
- Data Source
  KAKENHI-PROJECT-22790835
[Journal Article] In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders2011
- Author(s)
  Maeda J, Zhang MR, Okauchi T, Ji B, Ono M, Hattori S, Kumata K, Iwata N, Saido TC, Trojanowski JQ, Lee VM, Staufenbiel M, Tomiyama T, Mori H, Fukumura T, Suhara T, Higuchi M
- Journal Title
  
  J Neurosci.
  
  Volume: 31(12) Issue: 12 Pages: 4720-4730
- DOI
  10.1523/jneurosci.3076-10.2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590053, KAKENHI-PROJECT-22790835, KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235
[Journal Article] In Vivo Positron Emission Tomographic Imaging of Glial Responses to Amyloid-b and Tau Pathologies in Mouse Models of Alzheimer's Disease and Related Disorders2011
- Author(s)
  Maeda J, Zhang MR, Okauchi T, Bin Ji, Ono M, Hattori S, Kumata K, Iwata N, Saido TC, Trojanowski JQ, Lee VM, Staufenbiel M, Tomiyama T, Mori H, Fukumura T, Suhara T, Higuchi M.
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 12 Pages: 4720-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790835
[Journal Article] アルツハイマー病のホールマークと神経炎症の分子イメージング2011
- Author(s)
  季斌、樋口真人、須原哲也
- Journal Title
  
  最新医学
  
  Volume: 66巻10号 Pages: 77-83
- Data Source
  KAKENHI-PROJECT-22790835
[Journal Article] 認知症の分子イメージング2011
- Author(s)
  須原哲也,樋口真人,前田純,季斌
- Journal Title
  
  生物学的精神医学会誌
  
  Volume: 21巻4号 Pages: 261-266
- NAID
  10029785231
- Data Source
  KAKENHI-PROJECT-22790835
[Journal Article] In-vivo visualization of key molecular processes involved in Alzheimer's disease pathogenesis : Insights from neuroimaging research in humans and rodent models2010
- Author(s)
  Higuchi M, Maeda J, Bin Ji, Maruyama M, Okauchi T, Tokunaga M, Ono M, Suhara T
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: 1802 Pages: 373-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790835
[Journal Article] アルツハイマー病の分子イメージング2010
- Author(s)
  季斌、樋口真人、須原哲也
- Journal Title
  
  Pharma Medica
  
  Volume: 28巻7号 Pages: 39-43
- Data Source
  KAKENHI-PROJECT-22790835
[Journal Article] In-vivo visualization of key molecular processes involved in Alzheimer's disease pathogenesis : Insights from neuroimaging research in humans and rodent models2010
- Author(s)
  Higuchi, M., Maeda, J., Ji, B., Maruyama, M., Okauchi, T., Tokunaga, M., Ono, M., and Suhara, T
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1802 Issue: 4 Pages: 373-388
- DOI
  10.1016/j.bbadis.2010.01.003
- Data Source
  KAKENHI-PROJECT-22790835
[Journal Article] 脳内の"善玉"と"悪玉"を見分ける分子マーカー及びそのイメージング2009
- Author(s)
  季斌、樋口真人、須原哲也
- Journal Title
  
  ISOTOPE NEWS 661
  
  Pages: 2-5
- NAID
  10025107648
- Data Source
  KAKENHI-PROJECT-19790621
[Journal Article] Imaging Of Peripheral Benzodiazepine Receptor Expression As Biomarkers Of Detrimental Versus Beneficial Glial Responses In Mouse Models Of Alzheimer's And Other CNS Pathologies2008
- Author(s)
  Bin Ji, 他13名
- Journal Title
  
  Journal of Neuroscience 28
  
  Pages: 12255-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790621
[Journal Article] 神経変性疾患におけるグリア活性化反応の「善」と「悪」を見分ける分子イメージング2008
- Author(s)
  季斌、樋口真人、須原哲也
- Journal Title
  
  放射線の科学 52
  
  Pages: 10-13
- NAID
  40019063251
- Data Source
  KAKENHI-PROJECT-19790621
[Journal Article] Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's disease and other CNS pathologies2008
- Author(s)
  Ji B, et al.
- Journal Title
  
  Journal of Neuroscience 28
  
  Pages: 12255-12267
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023036
[Journal Article] Alpha-CaMKII deficiency causes immature dentate gyrus, a candidate endophenotype of psychiatric disorders2008
- Author(s)
  Yamasaki N, et al.
- Journal Title
  
  Molecular Brain 1
  
  Pages: 6-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023036
[Journal Article] Imaging Of Peripheral Benzodiazepine Receptor Expression As Biomarkers Of Detrimental Versus Beneficial Glial Responses In Mouse Models Of Alzheimer's And Other CNS Pathologies2008
- Author(s)
  Bin Ji, Jun Maeda, Makoto Sawada, Maiko Ono, Takashi Okauchi, Motoki Inaji, Ming-Rong Zhang, Kazutoshi Suzuki, Kiyoshi Ando, Matthias Staufenbiel, John Q. Trojanowski, Virginia M.-Y. Lee, Makoto Higuchiand Tetsuya Suhara
- Journal Title
  
  Journal of Neuroscience 28
  
  Pages: 12255-12267
- Data Source
  KAKENHI-PROJECT-19790621
[Journal Article] Phase-dependent roles of reactive microglia and astrocytes in nervous system injury as delineated by imaging of peripheral benzodiazepine receptor2007
- Author(s)
  Maeda J, Higuchi M, Inaji M, Bin Ji, Haneda E, Okauchi T, Zhang MR, Suzuki K, Suhara T
- Journal Title
  
  Brain Research 1157
  
  Pages: 100-111
- Data Source
  KAKENHI-PROJECT-19790621
[Journal Article] Longitudinal, quantitative assessment of amyloid, neuroinflammation and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by PET2007
- Author(s)
  Maeda J, Bin Ji, Irie T, Maruyama M, Okauchi T, Staufenbiel M, Iwata N, Saido T, Suzuki K, Higuchi M, Suhara T
- Journal Title
  
  Journal of Neuroscience 27
  
  Pages: 10957-10968
- Data Source
  KAKENHI-PROJECT-19790621
[Presentation] First-in-Human PET imaging of [11C]NCGG401 for colony-stimulating factor 1 receptor.2022
- Author(s)
  Ogata A, Ikenuma H, Nihashi T, Yasuno F, Morishita H, Abe J, Ichise M, Kato T, Ito K, Kimura Y.
- Organizer
  The 13th Congress of the World Federation of Nuclear Medicine and Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02876
[Presentation] PET imaging of [11C]NCGG401 for colony stimulating factor 1 receptor2021
- Author(s)
  Ogata A, Yamada T, Abe J, Ichise M, Ikenuma H, Koyama H, Suzuki M, Kato T, Ito K, Kimura Y
- Organizer
  NRM 2021 MAPPING NEURORECEPTORS AT WORK
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02876
[Presentation] RIPK1を標的とした新規ＰＥＴリガンド開発の試みと有効性の評価2021
- Author(s)
  池沼　宏、古山浩子、小懸綾、季斌、山田貴史、永井裕司、阿部潤一郎、市瀬正則、加藤隆司、鈴木正昭、木村泰之
- Organizer
  第61回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02876
[Presentation] Development of novel PET ligands to image the Receptor Interacting Protein Kinase 12021
- Author(s)
  Sakai T, Yamada T, Ikenuma H, Ogata A, Ichise M, Hattori S, Abe J, Suzuki M, Ito K, Kato T, Imamura S, Kimura Y
- Organizer
  NRM 2021 MAPPING NEURORECEPTORS AT WORK
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02876
[Presentation] Development of a novel PET ligand for receptor-interacting protein kinase 1 in brain2021
- Author(s)
  Ikenuma H, Ogata A, Koyama H, Yamada T, Abe J, Ichise M, Kato T, Suzuki M, Ito K, Kimura Y
- Organizer
  NRM 2021 MAPPING NEURORECEPTORS AT WORK
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02876
[Presentation] PET Imaging in Drug Development for Neurodegenerative Diseases.2020
- Author(s)
  Kimura Y
- Organizer
  The 14th International Conference on Complex Medical and Engineering
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02776
[Presentation] PET imaging of colony stimulating factor 1 receptor in rat brains.2019
- Author(s)
  Ogata A, Kimura Y, Yamada T, Ichise M, Ikenuma H, Abe J, Koyama H, Suzuki M, Kato T, Ito K.
- Organizer
  Brain & Brain PET 2019,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02776
[Presentation] Head-to-head comparison of two colony stimulating factor-1 receptor PET ligands, [11C]GW2580 and [11C]CPPC, for imaging of acute and chronic neuroinflammatory changes in mice2019
- Author(s)
  X. Zhou, C. Seki, M. Ono, M. Fujinaga, MR. Zhang, T. Saito, T. Saido, T. Suhara, B. Ji, M. Higuchi
- Organizer
  Brain & Brain PET 2019
- Data Source
  KAKENHI-PROJECT-19K08137
[Presentation] Development of PET imaging of Colony Stimulating Factor 1 Receptor Expressed on Microglia.2018
- Author(s)
  Ogata A, Kimura Y, Yamada T, Bin Ji, Seki C, Ichise M, Abe J, Ikenuma H, Koyama H, Suzuki M, Kato T, Ito K
- Organizer
  The XII International Symposium of Functional Neuroreceptor Mapping of the Living Brain
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02776
[Presentation] The evaluation of a novel PET ligand for colony stimulating factor 1 receptor in status epilepticus model rat brains.2018
- Author(s)
  Ogata A, Kimura Y, Yamada T, Bin Ji, Seki C, Ichise M, Abe J, Ikenuma H, Koyama H, Suzuki M, Kato T, Ito K
- Organizer
  nnual Congress of the European Association of Nuclear Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02776
[Presentation] In vitro and in vivo evaluation of inhibitory effect of dopamine on [18F]FE-PE2I binding to dopamine transporter in rat brains2017
- Author(s)
  Chie Seki, Masaki Tokunaga, Fumihiko Kodaka, Jun Maeda, Yasuyuki Kimura, Hiroyuki Takuwa, Yoko Ikoma, Hiroshi Ito, Tetsuya Suhara, and Makoto Higuchi
- Organizer
  BRAIN & BRAIN PET 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09978
[Presentation] グリアTSPOに選択的結合するPETリガンドを用いるアルツハイマー病関連神経炎症の検出2017
- Author(s)
  (1)季　斌
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09979
[Presentation] 腹腔内FDG投与後のPETによる人工受容体DREADDの神経活動制御作用の画像化2017
- Author(s)
  関　千江 , 季　斌 , 内田　翔子 , 南久松　丈晴 , 徳永　正希 , 前田　純 , 脇坂　秀克 , 永井　裕司 , 南本　敬史 , 須原　哲也 , 樋口　真人
- Organizer
  第57回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-15K09978
[Presentation] Critical role of microglia in pathogenesis of Alzheimer’s disease- Imaging-based study2016
- Author(s)
  季　斌
- Organizer
  第41回日本微小循環学会総会, 日本微小循環学会
- Place of Presentation
  日本、東京、品川、コクヨホール
- Invited
- Data Source
  KAKENHI-PROJECT-15K09979
[Presentation] Molecular Imaging for Diagnosis and Treatment in Dementia2016
- Author(s)
  Bin Ji
- Organizer
  The Second Global Conference of Chinese Professionals in , Chinese Society of Nuclear Medicine
- Place of Presentation
  中国、シンセン
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09979
[Presentation] In-vivo Imaging of Amyloid Deposited in Alzheimer’s Disease Model Mouse Brain with a 123I-labeled Ligand and Analysis for Binding Characteristic in Postmortem Human Brain2016
- Author(s)
  Bin Ji
- Organizer
  The Second Global Conference of Chinese Professionals in , Chinese Society of Nuclear Medicine
- Place of Presentation
  中国、シンセン
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09979
[Presentation] Imaging for Neuroinflammation in Preclinical and Clinical Studies2016
- Author(s)
  Bin Ji
- Organizer
  ASNM FORUM 2016
- Place of Presentation
  Shanghai, China
- Year and Date
  2016-05-06
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09979
[Presentation] Current State of Clinical Imaging for Neuroinflammation2015
- Author(s)
  Bin Ji
- Organizer
  World Molecular Imaging Congress 2015
- Place of Presentation
  Hawaii, Honolulu
- Year and Date
  2015-09-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09979
[Presentation] 神経変性疾患における神経炎症のPETイメージング2011
- Author(s)
  季斌、樋口真人、須原哲也
- Organizer
  第23回日本脳循環代謝学会総会シンポジウム
- Place of Presentation
  東京
- Year and Date
  2011-11-04
- Data Source
  KAKENHI-PROJECT-22790835
[Presentation] Molecular imaging for neuroinflammation2011
- Author(s)
  季斌
- Organizer
  第34回日本神経科学大会シンポジウム
- Place of Presentation
  横浜
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PROJECT-22790835
[Presentation] In vivo imaging and therapeutic modulations of microglial response to A-beta amyloidosis by interrupting deleterious chemokine signaling in a rodent model of Alzheimer's disease2010
- Author(s)
  Bin Ji, Maruyama M, Hattori S., Maeda J., Ono M., Okauchi T., Zhang MR., Higuchi M., Suhara T
- Organizer
  第29回内藤コンファレンス
- Place of Presentation
  神奈川県三浦郡
- Year and Date
  2010-10-07
- Data Source
  KAKENHI-PROJECT-22790835
[Presentation] PBR in astrocytes and microglia: relationship to negative and positive impacts of glial response to CNS pathologies2008
- Author(s)
  Bin Ji, Jun Maeda, Makoto Sawada, Maiko Ono, Takashi Okauchi, Motoki Inaji, Ming-Rong Zhang, Kazutoshi Suzuki, Kiyoshi Ando, John Q. Trojanowski , Virginia M.-Y. Lee, Makoto Higuchi and Tetsuya Suhara
- Organizer
  38th The Society of Neuroscience
- Place of Presentation
  Washington D.C.
- Data Source
  KAKENHI-PROJECT-19790621
[Presentation] PBR in astrocytes and microglia : relationship to negative and positive impacts of glial response to CNS pathologies2008
- Author(s)
  Bin Ji, 他12名
- Organizer
  38th The Society of Neuroscience
- Place of Presentation
  Washington DC, USA
- Year and Date
  2008-11-15
- Data Source
  KAKENHI-PROJECT-19790621

1. HIGUCHI Makoto (10373359)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. Minamimoto Takafumi (50506813)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. Kimura Yasuyuki (20423171)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
4. 池沼宏 (10751159)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
5. 小縣綾 (10805857)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
6. 古山浩子 (50402160)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
7. 加藤隆司 (60242864)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
8. 外山宏 (90247643)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
9. NAGAI Yuji (20415409)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SEKI Chie (40443080)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 鈴木弘美 (30340269)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. 鈴木正昭 (90093046)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. 今村真一 (40873203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 境崇行 (40881925)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 安野史彦 (60373388)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. KIKUCHI Erika

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. HIRABAYASHI Toshiyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. Aoki Ichio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 前田純

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
20. 廣田毅

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 佐原成彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
22. Zhou Xiaoyun

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ki Hin 季 斌

JI Bin 季 斌

Research Projects

Research Products

Co-Researchers

Development of PET imaging of brain immunity as a biomarker for drug development to treat neurodegenerative diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Targeting CSF1R as imaging biomarker of microgliaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

PET imaging of microglia, a novel drug target for neurodegenerative diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of next-generation PET ligand for neuroinflammation and comparison with current ligandsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

In vivo neural projection mapping technology with a novel PET ligand

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

In vivo brain activity imaging in DREADD expressed animals

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of neuroinflammation and responsible molecules in Alzheimer's disease onsetPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アミロイドカスケードのキープロセス可視化によるアルツハイマー病の診断・治療法開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research on the Role of Glial Cells in Alzheimer's Diseases-Using Molecular Imaging techniquesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Synthesis and evaluation of a novel PET ligand, a GSK’963 analog, aiming at autoradiography and imaging of the receptor interacting protein kinase 1 in the brain2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of a novel PET ligand, [11C]GO289 targeting CK2 expressed in the brain2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] [11C]NCGG401, a novel PET ligand for imaging of colony stimulating factor 1 receptors2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Detection of Alzheimer’s disease-related neuroinflammation by a PET ligand selective for glial versus vascular translocator protein2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PET imaging of colony-stimulating factor 1 receptor: A head-to-head comparison of a novel radioligand, 11C-GW2580, and 11C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey2021

Ki Hin 季斌

JI Bin 季斌