seki shuhji 関修司

… Alternative Names

SEKI Shuji 関修司

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Researcher Number	80531392
Affiliation (Current)	2025: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 免疫・微生物学, 教授
Affiliation (based on the past Project Information) *help	2017 – 2022: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 免疫・微生物学, 教授 2016: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 免疫・微生物学, 教授 2015: 防衛医科大学校, その他部局等, 教授 2015: 防衛医科大学校, 免疫微生物学, 教授 2015: 防衛医科大学校, 医学教育部医学科専門課程, 教授 … More 2015: 防衛医科大学校, 医学教育部医学科進学課程, 教授 2014 – 2015: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, その他部局等, 教授 2011 – 2014: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 教授 2012 – 2013: 防衛医科大学校, 医学教育部医学科専門課程, 教授 2012: 防衛医科大学校, 医学教育部医学科専門課, 教授 2011: 防衛医科大学校, 医学教育部・医学科専門課程, 教授 2010: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部・医学科専門課程, 教授 Less
Review Section/Research Field	Except Principal Investigator Experimental pathology / Emergency medicine / Pathological medical chemistry / Basic Section 49030:Experimental pathology-related / Basic Section 55060:Emergency medicine-related / General pharmacology / Radiation science / Integrated Nutrition Science / Gastroenterology
Keywords	Except Principal Investigator マクロファージ / Kupffer細胞 / NKT細胞 / 自然免疫 / クッパー細胞 / NK細胞 / LXR / 非アルコール性脂肪性肝炎 / 肝臓 / Kupffer cells … More / レスベラトロール / compromised hosts / 活性酸素 / 好中球 / クッパ－細胞 / インターロイキン6 / ビタミンD受容体 / Desmosterol / Compromised hosts / 抗菌活性評価チップ / 薬剤耐性菌敗血症 / Compromised hostｓ / MPLAプレコンディショニン / 抗菌活性測定チップ / 貪食細胞機能強化 / MPLAプレコンディショニング / LPSプレコンディショニング / compromised host / 薬剤耐性菌血症 / 貪食能 / 細菌 / アセトアミノフェン / 解糖 / 貪食細胞 / ピオグリタゾン / 免疫学 / CKD / AKI / NASH / NKT cells / コレステロール代謝 / 脂質代謝 / 肺炎球菌 / 特異的抗体 / anti-PPS antibody / anti-PspA antibody / 肺炎球菌表面タンパク / 莢膜多糖類 / 獲得免疫 / 貪食 / B細胞 / クッパ-細胞 / 急性肝障害 / ビタミンD誘導体 / サイトカイン / 胆汁酸 / 肝障害 / 放射線防護材 / 被曝後投与 / ビタミンＣ / 放射線 / 全身被ばく / ヘスペリジン / 放射線治療 / 糖転移へスぺリジン / 抗酸化アルブミン / 糖転移ビタミンC / ビタミンC / 放射線防護剤 / 脂肪滴 / ADFP / 脂肪肝 / 四塩化炭素 / 肝再生 / 合成CRP / グルココルチコイド受容体 / 核内受容体 / ナノ医学 / 重症感染症 / エンドトキシントレランス / 光線力学療法 / 止血ナノ粒子 / ナノシート / ursodepxycolic acid / 外科侵襲 / Angptl2 / 肝臓癌 / 肝臓線維化 / 非アルコール性脂肪肝炎 / 細菌感染 / マウス熱傷モデル / 免疫不全 / CD11b陽性Kupffer細胞 / CD68陽性Kupffer細胞 / CD11b陽性クッパー細胞 / CD68陽性クッパー細胞 / IL-18 / 熱傷後感染 / 複合免疫不全 / 熱傷 / ビリルビン / リトコール酸 / ノックアウトマウス / 炎症 / 胆汁鬱滞 Less

Analysis of liver immune cells using novel LXR stimulator
- Principal Investigator
  
  Nakashima Hiroyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  National Defense Medical College
Novel therapeutic strategy against drug-resistant bacterial sepsis in compromised hosts focusing on enhancing bactericidal activity of macrophages
- Principal Investigator
  
  Kinoshita Manabu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  National Defense Medical College
Mechanism of augmented phagocytic activity in liver by pioglitazone treatment
- Principal Investigator
  
  NAKASHIMA Masahiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  National Defense Medical College
The function of Kupffer cells in cholesterol metabolism
- Principal Investigator
  
  Nakashima Hiroyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  National Defense Medical College
Novel antioxidant therapy for radiation-induced injuries
- Principal Investigator
  
  Kinoshita Manabu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  National Defense Medical College
Immunological properties and functions of phagocytic B cells
- Principal Investigator
  
  NAKASHIMA Masahiro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Experimental pathology
- Research Institution
  National Defense Medical College
Management against surgical stress in compromised hosts
- Principal Investigator
  
  Kinoshita Manabu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Emergency medicine
- Research Institution
  National Defense Medical College
Role of the macrophages in non-alcoholic steatohepatitis and impaired glucose tolerance
- Principal Investigator
  
  Nakashima Hiroyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  National Defense Medical College
Resveratrol ameliorates high-fat-diet-induced fatty liver by increasing CD68 positive Kupffer cells.
- Principal Investigator
  
  Nishikawa Kahoko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrated Nutrition Science
- Research Institution
  Chuo University
  National Defense Medical College
Regulation of intestinal and hepatic immunity and metabolism by vitamin D receptor
- Principal Investigator
  
  MAKISHIMA Makoto
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nihon University
Unraveling the role of Angptl2 in the pathogenesis of steatohepatitis and liver cancer
- Principal Investigator
  
  TOMITA Kengo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  National Defense Medical College
Regulation of inflammation and metabolism by vitamin Dreceptor in hepatic immune cells
- Principal Investigator
  
  MAKISHIMA Makoto
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nihon University
Mechanical analyses and treatment of immunodeficiency following burn injury
- Principal Investigator
  
  KINOSHITA Manabu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  National Defense Medical College

[Book] Th1とTh2, サイトカインとケモカイン, 組織傷害と免疫,病態のしくみがわかる免疫学2010
- Author(s)
  木下学,関修司,阿保徹編
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Early treatment with C-reactive protein-derived peptide reduces septic acute kidney injury in mice via controlled activation of kidney macrophages2023
- Author(s)
  Ito Seigo、Goto Hiroyasu、Tanoue Keiko、Koiwai Kazuki、Ishikiriyama Takuya、Kearney Bradley M、Mori Kazuma、Nakashima Masahiro、Nakashima Hiroyuki、Kumagai Hiroo、Seki Shuhji、Kinoshita Manabu、Oshima Naoki
- Journal Title
  
  Journal of Leukocyte Biology
  
  Volume: 113 Issue: 4 Pages: 400-413
- DOI
  10.1093/jleuko/qiad015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07438, KAKENHI-PROJECT-21H03038
[Journal Article] Effects of L-Carnitine Treatment on Kidney Mitochondria and Macrophages in Mice with Diabetic Nephropathy2022
- Author(s)
  Ito Seigo、Nakashima Masahiro、Ishikiriyama Takuya、Nakashima Hiroyuki、Yamagata Akira、Imakiire Toshihiko、Kinoshita Manabu、Seki Shuhji、Kumagai Hiroo、Oshima Naoki
- Journal Title
  
  Kidney and Blood Pressure Research
  
  Volume: 47 Issue: 4 Pages: 277-290
- DOI
  10.1159/000522013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H03038, KAKENHI-PROJECT-20K07438
[Journal Article] Mouse Liver B Cells Phagocytose <i>Streptococcus pneumoniae</i> and Initiate Immune Responses against Their Antigens2022
- Author(s)
  Nakashima Masahiro、Kinoshita Manabu、Nakashima Hiroyuki、Kato Azusa、Mori Kazuma、Koiwai Kazuki、Shinomiya Nariyoshi、Seki Shuhji
- Journal Title
  
  The Journal of Immunology
  
  Volume: 209 Issue: 1 Pages: 26-37
- DOI
  10.4049/jimmunol.2100520
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H03038, KAKENHI-PROJECT-20K07438
[Journal Article] Effects of a CCR2 antagonist on macrophages and Toll-like receptor 9 expression in a mouse model of diabetic nephropathy2021
- Author(s)
  Ito Seigo、Nakashima Hiroyuki、Ishikiriyama Takuya、Nakashima Masahiro、Yamagata Akira、Imakiire Toshihiko、Kinoshita Manabu、Seki Shuhji、Kumagai Hiroo、Oshima Naoki
- Journal Title
  
  American Journal of Physiology-Renal Physiology
  
  Volume: 321 Issue: 6 Pages: F757-F770
- DOI
  10.1152/ajprenal.00191.2021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07438, KAKENHI-PROJECT-21H03038
[Journal Article] The Efficacy of Posttreatment with Synthetic C-Reactive Protein in Murine Bacterial Peritonitis via Activation of FcγRI-Expressing Kupffer Cells2021
- Author(s)
  Kinoshita Manabu、Ito Seigo、Ishikiriyama Takuya、Sekiguchi Kumiko、Yamaguchi Ryota、Tsuruhara Ryoichi、Matsuda Akihisa、Koiwa Kazuki、Nakashima Masahiro、Nakashima Hiroyuki、Miyashita Masao、Seki Shuhji
- Journal Title
  
  Journal of Innate Immunity
  
  Volume: Online ahead Issue: 5 Pages: 1-13
- DOI
  10.1159/000515333
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07438, KAKENHI-PROJECT-18H02907, KAKENHI-PROJECT-21H03038
[Journal Article] Contrasting functional responses of resident Kupffer cells and recruited liver macrophages to irradiation and liver X receptor stimulation2021
- Author(s)
  Ishikiriyama Takuya、Nakashima Hiroyuki、Endo-Umeda Kaori、Nakashima Masahiro、Ito Seigo、Kinoshita Manabu、Ikarashi Masami、Makishima Makoto、Seki Shuhji
- Journal Title
  
  PLOS ONE
  
  Volume: 16 Issue: 7 Pages: e0254886-e0254886
- DOI
  10.1371/journal.pone.0254886
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07438, KAKENHI-PROJECT-21H03038
[Journal Article] The role of Kupffer cells in systemic anti-microbial defense2021
- Author(s)
  Nakashima H, Nakashima M, Kinoshita M, Seki S
- Journal Title
  
  IntechOpen, Antimicrobial Immune Response
  
  Volume: 1 Pages: 1-13
- DOI
  10.5772/intechopen.97256
- ISBN
  9781839687822, 9781839687839
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02907, KAKENHI-PROJECT-21H03038
[Journal Article] Lipopolysaccharide Preconditioning Augments Phagocytosis of Malaria-Parasitized Red Blood Cells by Bone Marrow-Derived Macrophages in the Liver, Thereby Increasing the Murine Survival after Plasmodium yoelii Infection2021
- Author(s)
  Ono Takeshi、Yamaguchi Yoko、Nakashima Hiroyuki、Nakashima Masahiro、Ishikiriyama Takuya、Seki Shuhji、Kinoshita Manabu
- Journal Title
  
  Infection and Immunity
  
  Volume: 89 Issue: 11
- DOI
  10.1128/iai.00249-21
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07493, KAKENHI-PROJECT-20K07438, KAKENHI-PROJECT-21H03038
[Journal Article] Lipopolysaccharide preconditioning reduces liver metastasis of Colon26 cells by enhancing antitumor activity of natural killer cells and natural killer T cells in murine liver2020
- Author(s)
  Nishikawa Makoto、Kinoshita Manabu、Morimoto Yuji、Ishikiriyama Takuya、Nakashima Masahiro、Nakashima Hiroyuki、Ono Takeshi、Seki Shuhji、Moriya Tomoyuki、Yamamoto Junji、Kishi Yoji
- Journal Title
  
  Journal of Gastroenterology and Hepatology
  
  Volume: Online Issue: 7 Pages: 1889-1898
- DOI
  10.1111/jgh.15375
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07438, KAKENHI-PROJECT-18H02907, KAKENHI-PROJECT-17K10682
[Journal Article] The reduced bactericidal activity of neutrophils as an incisive indicator of water-immersion restraint stress and impaired exercise performance in mice2019
- Author(s)
  Kinoshita M, Nakashima, H, Nakashima M, Koga M, Toda H, Koiwi K, Morimoto Y, Miyazaki H, Saitoh D, Suzuki H, Seki S
- Journal Title
  
  Sci Rep
  
  Volume: 9 Issue: 1 Pages: 4662-4662
- DOI
  10.1038/s41598-019-41077-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02907, KAKENHI-PROJECT-17K08611, KAKENHI-PROJECT-17K10682, KAKENHI-PROJECT-17K11602
[Journal Article] Combination therapy using fibrinogen gamma-chain peptide-coated, adenosine-5’-diphosphate-encapsulated liposomes and hemoglobin vesicles for trauma-induced massive hemorrhage in thrombocytopenic rabbits2019
- Author(s)
  K. Hagisawa, M. Kinoshita, M. Takikawa, S. Takeoka, D. Saitoh, S. Seki, H. Sakai
- Journal Title
  
  Transfusion
  
  Volume: 59(10) Issue: 10 Pages: 3186-3196
- DOI
  10.1111/trf.15427
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H02087, KAKENHI-PROJECT-18H02907
[Journal Article] Immune mechanisms underlying susceptibility to endotoxin shock in aged hosts: implication in age-augmented generalized Shwartzman reaction2019
- Author(s)
  Kinoshita M, Nakashima M, Nakashima H, Seki S
- Journal Title
  
  Int J Mol Sci
  
  Volume: 20 Issue: 13 Pages: 3260-3260
- DOI
  10.3390/ijms20133260
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02907, KAKENHI-PROJECT-17K10682
[Journal Article] Pioglitazone improves phagocytic activity of liver recruited macrophages in elderly mice possibly by promoting glucose catabolism2019
- Author(s)
  Nakashima M, Kinoshita M, Nakashima H, Kotani A, Ishikiriyama T, Kato S, Hiroi S, Seki S
- Journal Title
  
  Innate Immun
  
  Volume: 25 Issue: 6 Pages: 356-368
- DOI
  10.1177/1753425919849620
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02907, KAKENHI-PROJECT-17K08611, KAKENHI-PROJECT-17K10682
[Journal Article] Repeated administration of alpha-galactosylceramide ameliorates experimental lupus nephritis in mice2018
- Author(s)
  Uchida, T. Nakashima, H. Yamagata, A. Ito, S. Ishikiriyama, T. Nakashima, M. Seki, S. Kumagai, H. Oshima, N.
- Journal Title
  
  Sci Rep
  
  Volume: 8 Issue: 1 Pages: 8225-8225
- DOI
  10.1038/s41598-018-26470-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08751
[Journal Article] Liver X receptors regulate hepatic F4/802018
- Author(s)
  Endo-Umeda, K. Nakashima, H. Komine-Aizawa, S. Umeda, N. Seki, S. Makishima, M.
- Journal Title
  
  Sci Rep
  
  Volume: 8 Issue: 1 Pages: 9281-9281
- DOI
  10.1038/s41598-018-27615-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08751
[Journal Article] Dysregulation of Kupffer Cells/Macrophages and Natural Killer T Cells in Steatohepatitis in LXRα Knockout Male Mice2018
- Author(s)
  Endo-Umeda Kaori、Nakashima Hiroyuki、Umeda Naoki、Seki Shuhji、Makishima Makoto
- Journal Title
  
  Endocrinology
  
  Volume: 159 Issue: 3 Pages: 1419-1432
- DOI
  10.1210/en.2017-03141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08751, KAKENHI-PROJECT-16K19061
[Journal Article] Activated natural killer T cells in mice induce acute kidney injury with hematuria through possibly common mechanisms shared by human CD562018
- Author(s)
  Uchida, T. Nakashima, H. Ito, S. Ishikiriyama, T. Nakashima, M. Seki, S. Kumagai, H. Oshima, N.
- Journal Title
  
  Am J Physiol Renal Physiol
  
  Volume: 3 Issue: 3 Pages: F618-F627
- DOI
  10.1152/ajprenal.00160.2018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08751
[Journal Article] Efficacy of Resuscitative Transfusion with Hemoglobin Vesicles in the Treatment of Massive Hemorrhage in Rabbits with Thrombocytopenic Coagulopathy and its Effect on Hemostasis by Platelet Transfusion2018
- Author(s)
  Hagisawa, Kohsuke; Kinoshita, Manabu; Takase, Bonpei; Hashimoto, Kenichi; Saitoh, Daizoh; Seki, Shuhji; Nishida, Yasuhiro; Sakai, Hiromi
- Journal Title
  
  Shock
  
  Volume: in press Issue: 3 Pages: 324-330
- DOI
  10.1097/shk.0000000000001042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11435, KAKENHI-PROJECT-18H02907
[Journal Article] In vivo Lipopolysaccharide Tolerance Recruits CD11b<sup>+</sup> Macrophages to the Liver with Enhanced Bactericidal Activity and Low Tumor Necrosis Factor-Releasing Capability, Resulting in Drastic Resistance to Lethal Septicemia2017
- Author(s)
  Kinoshita Manabu、Miyazaki Hiromi、Nakashima Hiroyuki、Nakashima Masahiro、Nishikawa Makoto、Ishikiriyama Takuya、Kato Shoichiro、Iwaya Keiichi、Hiroi Sadayuki、Shinomiya Nariyoshi、Seki Shuhji
- Journal Title
  
  Journal of Innate Immunity
  
  Volume: 9 Issue: 5 Pages: 493-510
- DOI
  10.1159/000475931
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08751, KAKENHI-PROJECT-15H04315
[Journal Article] In vivo LPS tolerance recruits CD11b+ macrophages to the liver with enhanced bactericidal activity and low TNF-releasing capability, resulting in drastic resistance to lethal septicemia.2017
- Author(s)
  Kinoshita M, Miyazaki H, Nakashima, H, Nakashima M, Nishikawa M, Ishikiriyama T, Kato S, Iwaya K, Hiroi S, Shinomiya N, Seki S.
- Journal Title
  
  J. Innate Immun.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670569
[Journal Article] Activation and increase of radio-sensitive CD11b+ recruited Kupffer cells/macrophages in diet-induced steatohepatitis in FGF5 deficient mice.2016
- Author(s)
  Nakashima H, Nakashima M, Kinoshita M, Ikarashi M, Miyazaki H, Hanaka H, Imaki J, Seki S.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 34466-34466
- DOI
  10.1038/srep34466
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462773, KAKENHI-PROJECT-16K08751, KAKENHI-PROJECT-26293295
[Journal Article] Treatment of irradiated mice with high-dose ascorbic acid reduced lethality.2015
- Author(s)
  Sato T, Kinoshita M, Yamamoto T, Ito M, Nishida T, Takeuchi M, Saitoh D, Seki S, Mukai Y.
- Journal Title
  
  PLoS ONE
  
  Volume: 10 Issue: 2 Pages: e0117020-e0117020
- DOI
  10.1371/journal.pone.0117020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26670569, KAKENHI-PROJECT-25293369
[Journal Article] Burn-Evoked Reactive Oxygen Species Immediately After Injury are Crucial to Restore the Neutrophil Function Against Postburn Infection in Mice2015
- Author(s)
  Miyazaki H, Kinoshita M, Ono S, Seki S, Saitoh D
- Journal Title
  
  Shock
  
  Volume: 44 Issue: 3 Pages: 252-257
- DOI
  10.1097/shk.0000000000000404
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462773, KAKENHI-PROJECT-25293369
[Journal Article] Mouse CD11b+Kupffer Cells Recruited from Bone Marrow Accelerate Liver Regeneration after Partial Hepatectomy2015
- Author(s)
  Nakashima, H.　Kinoshita, M.　Seki, S.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 9 Pages: e0136774-e0136774
- DOI
  10.1371/journal.pone.0136774
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460508
[Journal Article] Treatment with fibrinogen γ-chain peptide-coated, adenosine 5'-diphosphate-encapsulated liposomes as an infusible hemostatic agent against active liver bleeding in rabbits with acute thrombocytopenia2015
- Author(s)
  Hagisawa K, Nishikawa K, Yanagawa R, Kinoshita M, Doi M, Suzuki H, Iwaya K, Saitoh D, Seki S, Takeoka S, Handa M, Nishida Y.
- Journal Title
  
  Transfusion.
  
  Volume: 55 Issue: 2 Pages: 314-325
- DOI
  10.1111/trf.12829
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462843, KAKENHI-PROJECT-25504021, KAKENHI-PROJECT-25293369
[Journal Article] CD47 is an adverse prognostic factor and a therapeutic target in gastric cancer.2015
- Author(s)
  Yoshida K, Tsujimoto H, Matsumura K, Kinoshita M, Takahata R, Matsumoto Y, Hiraki S, Ono S, Seki S, Yamamoto J, Hase K.
- Journal Title
  
  Cancer Medicine
  
  Volume: 4 Issue: 9 Pages: 1322-1333
- DOI
  10.1002/cam4.478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293369
[Journal Article] Resveratrol increases CD68+ Kupffer cells colocalized with adipose differentiation-related protein and ameliorates high-fat-diet-induced fatty liver in mice.2015
- Author(s)
  Nishikawa K, Iwaya K, Kinoshita M, Fujiwara Y, Akao M, Sonoda M, Thiruppathi S, Suzuki T, Hiroi S, Seki S, Sakamoto T.
- Journal Title
  
  Mol Nutr Food Res
  
  Volume: 12 Issue: 6 Pages: 564-564
- DOI
  10.1002/mnfr.201400564
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590457, KAKENHI-PROJECT-25504021, KAKENHI-PROJECT-25460508, KAKENHI-PROJECT-25293369
[Journal Article] Fibroblast Growth Factor-5 Participates in the Progression of Hepatic Fibrosis2014
- Author(s)
  Hiromi Hanaka, Hiroyuki Nakashima, Shuhji Seki
- Journal Title
  
  Exp. Anim.
  
  Volume: 63 Issue: 1 Pages: 85-92
- DOI
  10.1538/expanim.63.85
- NAID
  130003391608
- ISSN
  0007-5124, 1341-1357, 1881-7122
- Language
  English
- Data Source
  KAKENHI-PROJECT-25460508
[Journal Article] Involvement of the TNF and FasL produced by CD11b Kupffer cells/macrophages in CCl4-induced acute hepatic injury.2014
- Author(s)
  Sato A, Nakashima H, Nakashima M, Ikarashi M, Nishiyama K, Kinoshita M, Seki S
- Journal Title
  
  PLoS ONE
  
  Volume: 9 Issue: 3 Pages: e92515-e92515
- DOI
  10.1371/journal.pone.0092515
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293369, KAKENHI-PROJECT-25460508, KAKENHI-PROJECT-26670569
[Journal Article] A combination of pre- and post-exposure ascorbic acid rescues mice from radiation-induced lethal gastrointestinal damage.2014
- Author(s)
  Ito Y, Kinoshita M, Yamamoto T, Sato T, Obara T, Saitoh D, Seki S, Takahashi Y.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 14 Issue: 10 Pages: 19618-35
- DOI
  10.3390/ijms141019618
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293369, KAKENHI-PROJECT-26670569
[Journal Article] Immunoenhancing therapy with interleukin-18 against bacterial infection in immunocompromised hosts after severe surgical stress2013
- Author(s)
  Kinoshita M, Miyazaki H, Ono S, Seki S
- Journal Title
  
  J. Leukocyte. Biol
  
  Volume: 93 Pages: 689-698
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Linezolid and vancomycin decrease the therapeutic effect of methylene blue-photodynamic therapy in a mouse model of MRSA bacterial arthritis2013
- Author(s)
  Tanaka, M.　Mroz, P.　Dai, T.　Huang, L.　Morimoto, Y.　Kinoshita, M.　Yoshihara, Y.　Shinomiya, N.　Seki, S.　Nemoto, K.　Hamblin, M. R.
- Journal Title
  
  Photochem Photobiol
  
  Volume: 89(3) Issue: 3 Pages: 679-82
- DOI
  10.1111/php.12040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300365, KAKENHI-PROJECT-23659599, KAKENHI-PROJECT-23659628, KAKENHI-PROJECT-25293369
[Journal Article] Immunoenhancing therapy with interleukin-18 against bacterial infection in immunocompromised hosts after severe surgical stress.2013
- Author(s)
  Kinoshita M, Miyazaki H, Ono S, Seki S
- Journal Title
  
  J. Leukocyte. Biol.
  
  Volume: 93 Issue: 5 Pages: 689-698
- DOI
  10.1189/jlb.1012502
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293369
[Journal Article] Glucocorticoid receptor-dependent immunomodulatory effect of ursodeoxycholic acid on liver lymphocytes in mice.2013
- Author(s)
  Takigawa T, Miyazaki H, Kinoshita M, Kawarabayashi N, Nishiyama K, Hatsuse K, Ono S, Saitoh D, Seki S, Yamamoto J
- Journal Title
  
  Am J Physiol-Gastr L
  
  Volume: 305 Issue: 6 Pages: G427-G438
- DOI
  10.1152/ajpgi.00205.2012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293369
[Journal Article] Activation of CD11b+ Kupffer cells/macrophages as a common cause for exacerbation of TNF/ Fas-ligand-dependent hepatitis in hypercholesterolemic mice.2013
- Author(s)
  Nakashima, H
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 1 Pages: e49339-e49339
- DOI
  10.1371/journal.pone.0049339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592027, KAKENHI-PROJECT-25293369
[Journal Article] The effect of synthetic C-reactive protein on the in vitro immune response of human PBMCs stimulated with bacterial reagents.2013
- Author(s)
  Sato A, Nakashima H, Kinoshita M, Nakashima M, Ogawa Y, Shono S, Ikarashi M, Seki S
- Journal Title
  
  Inflammation
  
  Volume: 36 Issue: 4 Pages: 781-792
- DOI
  10.1007/s10753-013-9604-4
- NAID
  130004638709
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293369
[Journal Article] Activation of CD11b+ Kupffer cells/macrophages as a common cause for exacerbation of TNF/ Fas-ligand-dependent hepatitis in hypercholesterolemic mice2013
- Author(s)
  Nakashima H, Ogawa Y, Shono S, Kinoshita M, Nakashima M, Sato A, Ikarashi M, Seki S
- Journal Title
  
  PLoS ONE
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] 合成CRPのヒト末梢血単核球に対する炎症性サイトカイン産生抑制効果と抗腫瘍活性増強効果2013
- Author(s)
  佐藤　厚志、木下学、中島弘幸、中島正裕、五十嵐正巳、関　修司
- Journal Title
  
  外科と代謝・栄養
  
  Volume: 47 Pages: 31-39
- NAID
  130004638709
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293369
[Journal Article] Distinct development and functions of resident and recruited liver Kupffer cells/macrophages.2013
- Author(s)
  Ikarashi M, Nakashima H, Kinoshita M, Sato A, Nakashima M, Miyazaki H, Nishiyama K, Yamamoto J, Seki S.
- Journal Title
  
  J. Leukocyte. Biol.
  
  Volume: 94 Issue: 6 Pages: 1325-1336
- DOI
  10.1189/jlb.0313144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293369, KAKENHI-PROJECT-25460508
[Journal Article] Fibrinogen γ-chain peptide-coated, adenosine diphosphate-encapsulated liposomes rescue thrombocytopenic rabbits from non-compressible liver hemorrhage2012
- Author(s)
  Nishikawa K, Hagisawa K, Kinoshita M, Shono S, Katsuno S, Doi M, Yanagawa R, Suzuki H, Iwaya K, Saitoh D, Sakamoto T, Seki S, Takeoka S, Handa M
- Journal Title
  
  J Thromb Haemost
  
  Volume: 10 Pages: 2137-2148
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Insulin treatment directly restores neutrophil phagocytosis and bactericidal activity in diabetic mice, thereby improving surgical site infection with Staphylococcus aureus2012
- Author(s)
  Yano H, Kinoshita M, Fujino K, Nakashima M, Yamamoto Y, Miyazaki H, Hamada K, Iwaya K, Saitoh D, Seki S, Tanaka Y
- Journal Title
  
  Infect Immun
  
  Volume: 80 Pages: 4409-4416
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Neutralization of IL-10 restores the down-regulation of IL-18 receptor on NK cells and IFN-γ production in septic mice, thus leading to an improved survival2012
- Author(s)
  Hiraki S, Ono S, Kinoshita M, Tsujimoto H, Takahata, R., Miyazaki H., Saitoh D, Seki S, Hase K
- Journal Title
  
  SHOCK
  
  Volume: 37 Pages: 177-82
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] The Liver as a Pivotal Innate Immune Organ.2012
- Author(s)
  Seki, S
- Journal Title
  
  Immuno-gastroenterology
  
  Volume: 1 Pages: 76-89
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Characterization of mouse liver phagocytic B cells in innate immunity2012
- Author(s)
  Nakashima M, Kinoshita M, Nakashima H, Habu Y, Miyazaki H, Hiroi S, Nakanishi K, Seki S
- Journal Title
  
  J. Leukocyte. Biol
  
  Volume: 91 Pages: 537-546
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] The Liver as a Pivotal Innate Immune Organ2012
- Author(s)
  Seki S, Nakashima H, Kinoshita M
- Journal Title
  
  Immuno-gastroenterology
  
  Volume: 1 Pages: 76-89
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Optimal photosensitizers for photodynamic therapy of infections should kill bacteria but spare neutrophils2012
- Author(s)
  Tanaka M, Kinoshita M, Yoshihara Y, Shinomiya N, Seki S, Nemoto K, Hamblin M, Dai T, Huang L, Morimoto Y
- Journal Title
  
  Photochem. Photobiol
  
  Volume: 88 Pages: 227-32
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Photodynamic therapy can induce a protective innate immune response against murine bacterial arthritis via neutrophil accumulation2012
- Author(s)
  Tanaka M, Mroz P, Dai T, Huang L, Morimoto Y, Kinoshita M, Yoshihara Y, Nemoto K, Shinomiya N, Seki S, Hamblin M
- Journal Title
  
  PLoS One
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Photodynamic therapy using intra-articular photofrin for murine MRSA arthritis: biphasic light dose response for neutrophil-mediated antibacterial effect2011
- Author(s)
  Tanaka M, Kinoshita M, Yoshihara Y, Shinomiya S, Seki S, Nemoto K, Hamblin M, Morimoto Y
- Journal Title
  
  Laser Surg Med
  
  Volume: 43 Pages: 221-229
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] The immunologic outcome of enhanced function of mouse liver lymphocytes and Kupffer cells by high-fat-cholesterol diet2011
- Author(s)
  Shono S, Habu Y, Nakashima M, Sato A, Nakashima H, Miyazaki H, Kinoshita M, Tsumatori G, Shinomiya N, Seki S
- Journal Title
  
  SHOCK
  
  Volume: 36 Pages: 484-93
- NAID
  40019087222
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Intraosseous transfusion with liposome-encapsulated hemoglobin improves mouse survival after hypohemoglobinemic shock without scavenging nitric oxide2011
- Author(s)
  Shono, S., Kinoshita, M., Takase, B., Nogami, Y., Kaneda, S., Ishihara, M., Saitoh, D., Kikuchi, M. and Seki, S
- Journal Title
  
  SHOCK
  
  Volume: 35 Pages: 45-52
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Antitumor immunity produced by the liver Kupffer cells, NK cells, NKT cells and CD8+ CD122+ T cells2011
- Author(s)
  Seki, S.
- Journal Title
  
  Clin.Dev.Immunol.
  
  Volume: 2011 Pages: 868345-868345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Antitumor immunity produced by the liver Kupffer cells, NK cells, NKT cells and CD8+ CD122+ T cells2011
- Author(s)
  Seki S, Nakashima H, Nakashima M, Kinoshita M
- Journal Title
  
  Clin. Dev. Immunol. 2011
  
  Volume: 2011 Pages: 864385-864385
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Enhancement of neutrophil function by IL-18 therapy protects burn-injured mice from MRSA infection.2011
- Author(s)
  Kinoshita M, Miyazaki H., Ono S, Inatsu, A., Nakashima, H., Tsujimoto, H., Shinomiya, N., Saitoh, D., Seki, S
- Journal Title
  
  Infect Immun
  
  Volume: 79 Pages: 2670-80
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Augmented bacterial elimination by Kupffer cells after IL-18 pretreatment via IFN-gamma produced from NK cells in burn-injured mice2011
- Author(s)
  Miyazaki H., Kinoshita M, Ono S, Nakashima M, Hara E, Ohno H, Seki S, Saitoh D
- Journal Title
  
  BURNS
  
  Volume: 37 Pages: 1208-1215
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Voltage gated potassium channel Kv1.3 blocker as apotential treatment for rat anti-glomerular basement membrane glomerulonephritis2010
- Author(s)
  Hyodo T, Oda T, Kikuchi Y, Higashi K, Kushiyama T, Yamamoto K, Yamada M, Suzuki S, Hokari Y, Kinoshita M, Seki S, Fujinaka F, Yamamoto T, Miura S, Kumagai H
- Journal Title
  
  Am. J. Physiol-Renal
  
  Volume: 299 Pages: 1258-1269
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Immunosuppression in the livers of mice with obstructive jaundice participates in their susceptibility to bacterial infection and tumor metastasis2010
- Author(s)
  Kawarabayashi, N., Seki, S., Hatsuse, K., Kinoshita, M., Takigawa, T., Tsujimoto, H., Kawabata, T., Nakashima, H., Shono, S., and Mochizuki, H
- Journal Title
  
  SHOCK
  
  Volume: 33 Pages: 500-506
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] The effect of ketamine anesthesia on the immune function of mice with postoperative septicemia2010
- Author(s)
  Takahashi, T., Kinoshita, M., Shono, S., Habu, Y., Ogura, T., Seki S., Kazama, T
- Journal Title
  
  Anesth Analg
  
  Volume: 111 Pages: 1051-1058
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Cardiac dysfunction induced by experimental myocardial infarction impairs the host defense response to bacterial infection in mice due to reduced phagocytosis of Kupffer cells2010
- Author(s)
  Nogami, Y., Kinoshita, M., Takase, B., Inatsu, A., Ishihara, M., Seki, S., and Maehara, T
- Journal Title
  
  J. Thorac. Cardiovasc. Surg.
  
  Volume: 140 Pages: 624-632
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Influence of Intraarticular Neutrophils on the Effects of Photodynamic Therapy for Murine MRSA Arthritis2010
- Author(s)
  Tanaka, M., Kinoshita, M., Yoshihara, Y., Shinomiya, N., Seki, S., Nemoto, K., Morimoto, Y
- Journal Title
  
  Photochem. Photobiol
  
  Volume: 86 Pages: 403-409
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Characteriation of two F4/80-positive Kupffer cell subsets by their function and phenotype in mice2010
- Author(s)
  Kinoshita, M., Uchida, T., Sato, A., Nakashima, M., Nakashima H., Shono S., Habu, Y., Miyazaki, H., Hiroi, S., Seki, S
- Journal Title
  
  J. Hepatol
  
  Volume: 53 Pages: 903-910
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Pretreatment with ascorbic acid prevents lethal gastrointestinal syndrome in mice receiving a massive amount of radiation2010
- Author(s)
  Yamamoto, T., Kinoshita, M., Shinomiya, N., Hiroi, S., Sugasawa, H., Matsushita, Y., Majima, T., Saitoh, D., Seki, S
- Journal Title
  
  J. Radiat. Res.
  
  Volume: 51 Pages: 145-156
- NAID
  10025914571
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] Linezolid and vancomycin decrease the therapeutic effect of methylene blue-photodynamic therapy in a mouse model of MRSA bacterial arthritis
- Author(s)
  Tanaka M, Mroz P, Dai T, Huang L, Morimoto Y, Kinoshita M, Yoshihara Y, Shinomiya N, Seki S, Nemoto K, Hamblin M
- Journal Title
  
  Photochem. Photobiol
- Data Source
  KAKENHI-PROJECT-22592027
[Journal Article] The effect of synthetic C-reactive protein on the in vitro immune response of human PBMCs stimulated with bacterial reagents
- Author(s)
  Sato A, Nakashima H, Kinoshita M, Nakashima M, Ogawa Y, Shono S, Ikarashi M, Seki S
- Journal Title
  
  Inflammation
- NAID
  130004638709
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] Pioglitazone reinforces liver innate immunity against bacterial infection in aged mice.2020
- Author(s)
  Nakashima Masahiro, Kinoshita Manabu, Nakashima Hiroyuki, Seki Shuhji.
- Organizer
  第93回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-17K08611
[Presentation] LPS プレコンディショニングによる肝マクロファージの殺菌能増強とグラム陰性陽性両敗血症への救命効果2018
- Author(s)
  木下　学, 宮﨑　裕美, 中島　正裕, 中島　弘幸 , 石切山　拓也, 加藤　章一郎, 四ノ宮　成祥, 関　修司
- Organizer
  日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] LPS preconditioning potently enhances liver antitumor activity in mice despite marked suppression of inflammatory response2018
- Author(s)
  Kinoshita M, Nishikawa M, Nakashima H, Nakashima M, Ishikiriyama T, Kato S, Seki S
- Organizer
  日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-18H02907
[Presentation] Liver X Receptor activation exerts the different effects on the function of liver resident Kupffer cells and recruited macrophages2018
- Author(s)
  Takuya Ishikiriyama, Hiroyuki Nakashima, Shoichiro Kato, Kori Endo-Umeda, Masahiro Nakashima, Manabu Kinoshita, Makoto Makishima, Shuhji Seki
- Organizer
  2018年度　日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] Pioglitazone prevents sepsis in old mice by enhancing liver innate immunity2018
- Author(s)
  Masahiro Nakashima, Hiroyuki Nakashima, Manabu Kinoshita, Takuya Ishikiriyama, Shoichiro Kato, Shuhji Seki
- Organizer
  2018年度　日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] Basic fibroblast growth factor-loaded PLGA nanosheet promotes wound healing of refractory skin lesions after burn injury2018
- Author(s)
  Kinshita M, Aoki S, Kiyosawa T, Fujie T, Takeoka S, Hagisawa K, Seki S
- Organizer
  Annual Conference on SHOCK
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02907
[Presentation] LPS preconditioningによる抗腫瘍活性増強効果と外科周術期管理での有用性2018
- Author(s)
  木下学、西川誠、中島正裕、中島弘幸、関修司
- Organizer
  日本エンドトキシン自然免疫研究会
- Data Source
  KAKENHI-PROJECT-18H02907
[Presentation] LPS tolerance を用いたグラム陰性陽性両敗血症に対する救命治療戦略の可能性2017
- Author(s)
  木下　学, 宮﨑　裕美, 中島　正裕, 中島　弘幸 , 萩沢　康介, 関　修司
- Organizer
  日本Shock 学会総会
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] Medical countermeasures using LPS tolerance to address lethal toxic shock and fatal bacterial sepsis2017
- Author(s)
  Manabu Kinoshita, Nariyoshi Shinomiya, Hiromi Miyazaki, Hiroyuki Nakashima , Masahiro Nakashima, ShujiSeki
- Organizer
  Chemical and Biological Defense Science & Technology Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] LPS tolerance recruits CD11b+ macrophages to the liver with enhanced bactericidal activity and low TNF-releasing capability, resulting in drastic resistance to lethal septicemia2017
- Author(s)
  Kinoshita Manabu, Miyazaki Hiromi, Nakashima Masahiro, Nakashima Hiroyuki, Ishikiriyama Takuya, Kato Shoichiro, Shinomiya Nariyoshi, Seki Shuhji
- Organizer
  日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] In vivo LPS tolerance recruits CD11b+ macrophages to the liver with enhanced bactericidal activity and low TNFreleasing capability, resulting in drastic resistance to lethal septicemia2017
- Author(s)
  Kinoshita Manabu, Miyazaki Hiromi, Nakashima Hiroyuki, Nakashima Masahiro, Nishikawa Makoto, Hagisawa Kohsuke, Seki Shuhji
- Organizer
  2017 Shock Society： Shock 47
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] Repeated administrations of α- galactosylceramide slow the progression of lupus nephritis in BWF1 mice2017
- Author(s)
  Nakashima Masahiro, Uchida Takahiro, Ito Seigo, Ishikiriyama Takuya, Nakashima Hiroyuki, Kumagai Hiroo, Seki Shuhji
- Organizer
  日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] Liver sinusoidal endothelial cells and resident Kupffer cells are involved in cholesterol metabolism in mice2017
- Author(s)
  Nakashima Hiroyuki, Kato Shoichiro, Ishikiriyama Takuya, Nakashima Masahiro, Kinoshita Manabu, Seki Shuhji
- Organizer
  日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] Excessive activation of liver natural killer cells and phenotypic alteration and dysfunction of Kupffer cells in diabetic mice with sepsis, and reversal by insulin treatment2016
- Author(s)
  Kinoshita,M. Miyazaki, H. Nakashima, H. Nakashima, M. Seki, S.
- Organizer
  The 45th Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  Okinawa Convention Center
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] Activation of PPAR gamma protects against postburn infection by regulating innate immune response2016
- Author(s)
  Miyazaki, H. Kinoshita,M. Nakashima, H. Nakashima, M. Seki, S.
- Organizer
  The 45th Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  Okinawa Convention Center
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] 腹部救急疾患における汚染手術での術後癒着軽減への挑戦ーPLAナノシートの癒着防止効果の特徴ー2016
- Author(s)
  木下学、檜顕成、齊藤晃広、内田広夫、武岡真司、関修司
- Organizer
  第52回日本腹部救急医学会総会
- Place of Presentation
  東京
- Year and Date
  2016-03-03
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] 転写因子活性化による重症熱傷後感染対策2016
- Author(s)
  宮崎裕美、木下学、関修司、戸村哲、齊藤大蔵
- Organizer
  第24回日本熱傷学会関東地方会
- Place of Presentation
  東京
- Year and Date
  2016-02-20
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] Activation and increase of radio-sensitive CD11b+ recruited Kupffer cells/macrophages in diet-induced steatohepatitis in FGF5 deficient mice2016
- Author(s)
  Nakashima, H. Nakashima, M. Kinoshita,M. Seki, S.
- Organizer
  The 45th Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  Okinawa Convention Center
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K08751
[Presentation] 加齢に伴う自然免疫機構の低下とピオグリタゾン投与による増強2016
- Author(s)
  Nakashima, H.　Kinoshita, M.　Seki, S.
- Organizer
  第89回日本細菌学会総会
- Place of Presentation
  大阪　日本
- Year and Date
  2016-03-23
- Data Source
  KAKENHI-PROJECT-25460508
[Presentation] Mouse CD11b+Kupffer cells recruited from bone marrow accelerate liver regeneration after partial hepatectomy2015
- Author(s)
  Nakashima, H.　Kinoshita, M.　Seki, S.
- Organizer
  Liver meeting 2015 AASLD
- Place of Presentation
  San Francisco, USA
- Year and Date
  2015-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460508
[Presentation] Decreased innate immunity in aged mice and improvemet by pioglitazone pretreatment2015
- Author(s)
  Nakashima, H.　Kinoshita, M.　Seki, S.
- Organizer
  第44回日本免疫学会
- Place of Presentation
  札幌　日本
- Year and Date
  2015-12-19
- Data Source
  KAKENHI-PROJECT-25460508
[Presentation] Resveratrol increases cd68+kupffer cells co-localized with adipose differentiation-related protein (adfp) and ameliorates high-fat-diet-induced fatty liver in mice.2015
- Author(s)
  K Nishikawa, K .Iwaya, M Knoshita, Y Fujiwara, S Thiuppathi, T Suzuki, S Seki, T Sakamoto
- Organizer
  4th European Congress of Immunology 2015
- Place of Presentation
  ウィーン　（オーストリア　）
- Year and Date
  2015-09-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25504021
[Presentation] Biosecurity concern related to recent development of life science technology2015
- Author(s)
  Shinomiya N, Kinoshita M, Seki S, Minehata M, Dando M
- Organizer
  2015 Chemical Biological Defense & Technology Conference
- Place of Presentation
  St Louis
- Year and Date
  2015-05-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] 家兎での血小板減少時の肝損傷に対する人工血小板による止血救命2015
- Author(s)
  木下学、萩沢康介、西川可穂子、柳川錬平、関修司
- Organizer
  第51回日本腹部救急医学会
- Place of Presentation
  京都
- Year and Date
  2015-03-06
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] Burn-evoked ROS immediately after injury are crucial to rescue the neutrophil function against post-burn infection in mice2015
- Author(s)
  Kinoshita M, Miyazaki H, Ono S, Hagisawa K, Saitoh D, Seki S,
- Organizer
  38th Annual congress on Shock
- Place of Presentation
  Denver CO
- Year and Date
  2015-06-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] Peroxisome proliferator activated receptor-gamma agonist improves survival in a murine model of postburn infection by modulating the macrophage function2015
- Author(s)
  Miyazaki H, Kinoshita M, Hagisawa K, Seki S, Saitoh D.
- Organizer
  38th Annual congress on Shock
- Place of Presentation
  Denver CO
- Year and Date
  2015-06-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] Fibroblast growth factor 5欠損マウスは高脂肪食によりCD11b陽性Kupffer細胞を活性化させ脂肪性肝炎を発症する2015
- Author(s)
  Nakashima, H.　Kinoshita, M.　Seki, S.
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  熊本　日本
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25460508
[Presentation] 人工赤血球や人工血小板などの血液代替物の開発とその将来展望2014
- Author(s)
  木下学、萩沢康介、西川可穂子、柳川錬平、小野　聡、齋藤大蔵、高瀬凡平、酒井宏水、半田誠、武岡真司、関修司
- Organizer
  第114回日本外科学会定期学術集会　(パネルデスカッション1-3)
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] Nobel therapeutic strategy against burn-wound bacterial infection using antibiotic-loaded nanosheet.2014
- Author(s)
  Kinoshita M, Saito A, Miyazaki H, Fujie T, Takeoka S, Shinomiya N, Seki S
- Organizer
  第86回日本細菌学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] Glucocorticoid receptor-dependent immunomodurately effect of ursodeoxycholic acid on liver lymphocytes in mice.2013
- Author(s)
  Kinoshita M, Miyazaki H, Nakashima H, Ikarashi M, Seki S
- Organizer
  15th International congress of Immunology
- Place of Presentation
  Milan
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] Distinct development and function of resident and recruited liver Kupffer cells / macrophages2013
- Author(s)
  Masami Ikarashi, Hiroyuki Nakashima, Manabu Kinoshita, Shuhji Seki
- Organizer
  日本免疫学会
- Place of Presentation
  千葉　幕張
- Data Source
  KAKENHI-PROJECT-25460508
[Presentation] 糖尿病マウスでの創部感染増悪への好中球機能不全の関与トインスリン治療2013
- Author(s)
  木下学、矢野秀和、小野聡、浜田耕司、田中祐司、関修司
- Organizer
  第50回日本外科代謝栄養学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] Activation of CD11b+ Kupffer cells/macrophages as a common cause for exacerbation of TNF/ Fas-ligand-dependent hepatitis in hypercholesterolemic mice2013
- Author(s)
  Hiroyuki Nakashima, Manabu Kinoshita, Shuhji Seki
- Organizer
  国際免疫学会議
- Place of Presentation
  イタリア　ミラノ
- Data Source
  KAKENHI-PROJECT-25460508
[Presentation] Glucocorticoid receptor-dependent immunomodulatory effect of ursodeoxycholic acid and on liver lymphocytes in mice2013
- Author(s)
  Manabu Kinoshita, Hiroyuki Nakashima, Shuhji Seki
- Organizer
  日本免疫学会
- Place of Presentation
  千葉　幕張
- Data Source
  KAKENHI-PROJECT-25460508
[Presentation] CD11b+ Kupffer cells/macrophages accelarates liver regeneration after partial hepatectomy2013
- Author(s)
  Kiyoshi Nishiyama, Hiroyuki Nakashima, Manabu Kinoshita, Shuhji Seki
- Organizer
  日本免疫学会
- Place of Presentation
  千葉　幕張
- Data Source
  KAKENHI-PROJECT-25460508
[Presentation] 熱傷などの重度外科侵襲に続発する複合免疫不全病態とIL-18による免疫賦活.2013
- Author(s)
  木下学、宮崎裕美、小野聡、関修司
- Organizer
  第26回日本外科感染症学会総会(パネルデスカッション)
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] Resveratrol increases CD68 positive Kupffer cells with phagocytic activity to lipid droplets and ameliorates high-fat diet induced fatty liver in mice2013
- Author(s)
  Nishikawa K, Kinoshita M, Iwaya K, Sakamoto T, Seki S.
- Organizer
  第42回日本免疫学会総会
- Place of Presentation
  幕張（千葉）
- Data Source
  KAKENHI-PROJECT-25504021
[Presentation] 大量出血後の血小板減少状態下での肝外傷出血に対するH12(ADP)リポソーム投与の止血救命効果.2013
- Author(s)
  萩沢康介、木下学、西川可穂子、柳川錬平、土井麻実、武岡真司、齋藤大蔵、関修司、西田育弘、半田誠
- Organizer
  日本血栓止血学会第85回学術集会
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-25293369
[Presentation] Pioglitazone Improves Mouse Survival After Post-Burn Bacterial Infection Via Restoration of Kupffer Cell Function2011
- Author(s)
  Miyazaki H, Kinoshita M, Ono S, Seki S, Saitoh D
- Organizer
  18th Annual Meeting of Society for Free Radical Biology and Medicine
- Place of Presentation
  Atlanta, USA
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] Interleukin-18 treatment following burn injury activates Kupffer cell phagocytosis in mice2010
- Author(s)
  Miyazaki H, Kinoshita M, Ono S, Hara E, Takagi T, Seki S, Saitoh D
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  Kobe Japan
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] Interleukin-18 therapy enhances Kupffer cell-mediated bacterial elimination in post-burn infection models via the activation of NK cell function2010
- Author(s)
  Kinoshita M, Shinomiya N, Miyazaki H, Ono S, Saitoh D, Seki S
- Organizer
  Chemical and Biological Defense Science and Technology (CBD S&T) 2010
- Place of Presentation
  Orland, USA
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] Activation of NK cells by IL-18 augments bacterial elimination by Kupffer cells in the burn-injured mice2010
- Author(s)
  Miyazaki H, Kinoshita M, Ono S, Nakashima M, Hara E, Ohno H, Seki S, Daizoh D
- Organizer
  Society for Free Radical Biology and Medicine 17th Annual Meeting
- Place of Presentation
  Orlando, USA
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] Characterization of two F4/80-positive Kupffer cell subsets by their function and phenotype in mice2010
- Author(s)
  Kinoshita M, Uchida T, Sato A, Nakashima M, Nakashima H, Shono S, Habu Y, Miyazaki H, Seki S
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  Kobe Japan
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] CpG-oligodeoxynucleotides challenge induces severe multi-organ damage and lethality via TNF and FasL-mediated NKT cell activation in aged mice2010
- Author(s)
  Kinoshita M, Shinomiya N, Kawabata T, Seki S
- Organizer
  Chemical and Biological Defense Science and Technology (CBD S&T) 2010
- Place of Presentation
  Orland, USA
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] マウスおよびヒト肝Kupffer細胞/マクロファージの表面抗原、発生分化、機能による包括的分類の新規確立
- Author(s)
  Masami Ikarashi, Hiroyuki Nakashima, Manabu Kinoshita, Shuhji Seki
- Organizer
  日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2014-05-29 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-25460508
[Presentation] Activated CD11b+ Kupffer cells/macrophages play the pivotal role in diet induced steatohepatitis in fibroblast growth factor 5 deficient mice
- Author(s)
  Hiroyuki Nakashima, Manabu Kinoshita, Shuhji Seki
- Organizer
  日本免疫学会総会
- Place of Presentation
  京都
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25460508
[Presentation] In vivo endotoxin tolerance alters Kupffer cell phenotype and drastically enhances their bacterial killing
- Author(s)
  Manabu Kinoshita, Hiroyuki Nakashima, Shuhji Seki
- Organizer
  日本免疫学会総会
- Place of Presentation
  京都
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25460508
[Presentation] Involvement of the TNF and FasL produced by CD11b Kupffer cells/macrophages in CCl4-induced acute hepatic injury
- Author(s)
  Hiroyuki Nakashima, Atsushi Sato, Manabu Kinoshita, Shuhji Seki
- Organizer
  アメリカ肝臓学会
- Place of Presentation
  アメリカ　ボストン
- Year and Date
  2014-11-07 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-25460508
[Presentation] Liver X receptor modulates innate immune response in hepatic mononuclear cells
- Author(s)
  Endo-Umeda Kaori, Hiroyuki Nakashima, Shuhji Seki
- Organizer
  日本免疫学会総会
- Place of Presentation
  京都
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25460508

1. KINOSHITA Manabu (70531391)

# of Collaborated Projects: 9 results

# of Collaborated Products: 98 results
2. Nakashima Hiroyuki (10574064)

# of Collaborated Projects: 6 results

# of Collaborated Products: 50 results
3. NAKASHIMA Masahiro (70738103)

# of Collaborated Projects: 5 results

# of Collaborated Products: 31 results
4. ONO Satoshi (30531355)

# of Collaborated Projects: 4 results

# of Collaborated Products: 26 results
5. SAITOH Daizoh (90531632)

# of Collaborated Projects: 3 results

# of Collaborated Products: 20 results
6. MIYAZAKI Hiromi (30531636)

# of Collaborated Projects: 3 results

# of Collaborated Products: 25 results
7. SAKAMOTO Toshihisa (50178571)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
8. NISHIKAWA Kahoko (20345416)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
9. SHINOMIYA Nariyoshi (40505260)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
10. Takeoka Shinji (20222094)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. MAKISHIMA Makoto (70346146)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. UMEDA Kaori (10445744)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. ISHIZAWA Michiyasu (30646542)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. Morimoto Yuji (10449069)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
15. SAKURAI Kenichi (20366602)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. TOMITA Kengo (50317129)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. OIKE Yuichi (90312321)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. Tanaka Yuji (50221396)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. Takahashi Tetsuya (00589905)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. Hagisawa Kosuke (50539244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
21. Hinoki Akinari (90383257)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. Handa Makoto (40129614)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
23. Iwaya Keiichi (50312012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
24. Fujiwara Yoko (50293105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
25. Maruyama Toru (90423657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. Nakanishi Kuniaki (60523115)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 異島優 (00457590)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 山本哲生 (20647979)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 加地辰美 (50148110)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 石塚俊晶 (30399117)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 鈴木博章 (20282337)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
32. YAMADA Sachiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. NISHIDA Shigeru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. UMEDA Naoki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. SAKAI Hiromi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
36. ISHIKAWA Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 熊谷裕生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 土田英俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
39. 鈴木英紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 小野岳史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 小田美規

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

seki shuhji 関 修司

SEKI Shuji 関 修司

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[Book] Th1とTh2, サイトカインとケモカイン, 組織傷害と免疫,病態のしくみがわかる免疫学2010

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[Journal Article] Early treatment with C-reactive protein-derived peptide reduces septic acute kidney injury in mice via controlled activation of kidney macrophages2023

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[Journal Article] Effects of L-Carnitine Treatment on Kidney Mitochondria and Macrophages in Mice with Diabetic Nephropathy2022

seki shuhji 関修司

SEKI Shuji 関修司