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Fukushige Shinichi  福重 真一

… Alternative Names

FUKUSHIGE Shinichi  福重 真一

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Researcher Number 90192723
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-0588-6376
Affiliation (Current) 2025: 東北大学, 医学系研究科, 特任教授
Affiliation (based on the past Project Information) *help 2021 – 2024: 東北大学, 医学系研究科, 特任教授
2016 – 2020: 東北大学, 医学系研究科, 准教授
2012 – 2015: 東北大学, 医学(系)研究科(研究院), 准教授
2009 – 2011: Tohoku University, 大学院・医学系研究科, 准教授
2007: Tohoku University, Tohoku University School of Medicine, Department of Molecular Pathology, Associate Professor … More
2006: Tohoku University, Graduate School of Medicine, Associate Professor, 大学院医学系研究科, 助教授
2005: 東北大学, 大学院・医学系研究科, 助教授
1999 – 2002: Tohoku University, School of Medicine, Department of Molecular Pathology, Lecturer, 大学院・医学系研究科, 講師
1995 – 1999: 東北大学, 医学部, 助手
1988: Osaka University,Research Associate, 細胞工学センター, 助手 Less
Review Section/Research Field
Principal Investigator
Experimental pathology / Basic Section 49030:Experimental pathology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Molecular biology / Laboratory animal science
Except Principal Investigator
Human pathology / Basic Section 50020:Tumor diagnostics and therapeutics-related / 分子遺伝学・分子生理学 / Experimental pathology / General surgery / Digestive surgery
Keywords
Principal Investigator
遺伝子 / 発現制御 / DNAメチル化 / 前立腺癌 / ゲノム / 癌 / アポトーシス / PYCARD / hPMS2 / hMLH1 … More / 転写活性化 / 脱メチル化 / DNA脱メチル化 / エピジェネティクス / メチルCpG結合蛋白 / 転写抑制 / 腫瘍 / ZNF750―TWIST1経路 / 転移 / qMSP / ZNF750 / cfDNA / リキッドバイオプシー / モデルマウス / 細胞増殖 / Epigenetics / Methyl-CpG binding protein / Transcriptional silencing / Regulation of gene expression / Gene / two-hybrid assay / missense mutation / HNPCC / DNA mismatch repair / 胚細胞変異 / 遺伝性非腺種症性大腸癌 / 2ハイブリッドアッセイ / ミスセンス変異 / 遺伝性非腺腫症性大腸癌 / DNAミスマッチ修復 / 遺伝子発現マイクロアレイ / マイクロアレイ / MeTA / RNA干渉 / Cre / 部位特異的組換え / DNA多型性マーカー / YAC trasfer / contact inhibition / APC遺伝子 / TAR法 / Cre-lox部位特異的組換え / YAC transfer / 癌抑制遺伝子 / アレロタイプ解析 / マイクロサテライトマーカー … More
Except Principal Investigator
18q / 12q / 膵癌 / 17p / 6q / tumor suppressor gene / 癌抑制遺伝子 / RFP / MBD4 / 遺伝子 / RIZ / MSI / 1p36-p35 / 染色体 / BAC / ゲノム / 遺伝子治療 / pancreatic cancer / 染色体欠失 / TGFBβレセプターII型 / 癌遺伝子 / DNAミスマッチ修復異常 / qMSP / デジタルPCR / リキッドバイオプシー / DNAメチル化 / 癌 / Dual Laser / Cell Sorter / デュアルレーザー / セルソーター / Methyl-CpG binding protein / Transcriptional silencing / Regulation of expression / Gene / RNA干渉法によるRFPノックダウン / MBD4の転写抑制活性へのRFP蛋白の関与 / メチルCpG結合蛋白MBD4 / メチルCpG結合蛋白 / 転写抑制 / 発現制御 / Gene Therapy / BAI1 / SMAD4 / Pancreatic Cancer / 1p / 遺伝子変異 / 膵がん / BAI1遺伝子 / RIZ遺伝子 / BaI1遺伝子 / SMAD4遺伝子 / Chromosome / bq / Genome / Pancreatic cancer / STS / 膵臓がん / angiogenesis / gene therapy / FISH / CGH / LOH / 染色体異常 / 遺伝子異常 / 早期診断 / 診療システム / 血管新生 / DNA mismatch repair error / IGFII receptor / TGF beta receptor type II / chromosome 20q / chromosome 12q / human pancreatic cancer / oncogene / IGFIIレセプター / TGFβレセプターII型 / 染色体20番長腕 / 染色体12番長腕 / the PTEN gene / the DMBT1 gene / neuroblastoma / renal cell carcinoma / lung cancer / endometrial cancer / 子宮体癌 / 胃癌 / hMSH2遺伝子 / IGFIIレセレプター / hMSII6遺伝子 / BAX遺伝子 / H-cadherin遺伝子 / DUSP6遺伝子 / PTEN遺伝子 / DMBT1遺伝子 / 神経芽細胞腫 / 腎癌 / 肺癌 / 子宮内膜癌 / APエンドヌクレアーゼ / 光回復 / 皮膚癌 / 紫外線 / ミスマッチ修復 / 塩基除去修復 / マクレオチド除去修復 / p53 / プロテアソーム / 遺伝子クローニング / HNPCC / ノックアウトマウス / コケイン症候群 / 酸化的DNA損傷 / 色素性乾皮症 / 発がん / 転写 / DNA修復 Less
  • Research Projects

    (19 results)
  • Research Products

    (72 results)
  • Co-Researchers

    (21 People)
  •  Elucidation of ZNF750-TWIST1 pathway in prostate cancer metastasisPrincipal Investigator

    • Principal Investigator
      福重 真一
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      Tohoku University
  •  Development of liquid biopsy technology targeting DNA methylation for prostate cancer diagnosisPrincipal Investigator

    • Principal Investigator
      福重 真一
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Tohoku University
  •  Development of diagnostic technique of pancreatic cancer by using liquid biopsy targeted DNA methylation markers

    • Principal Investigator
      Gu Zhaodi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Tohoku University
  •  Role of PYCARD, an apoptosis-inducing gene, in prostatic tumorigenesisPrincipal Investigator

    • Principal Investigator
      Fukushige Shinichi
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      Tohoku University
  •  Identification of hypermethylated genes associated with increased cell proliferation of prostate cancer using DNA demethyation techniquesPrincipal Investigator

    • Principal Investigator
      Fukushige Shinichi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Tohoku University
  •  Development of DNA demethylation technology in cancer cells and its application for discovering biomarkers for early diagnosisPrincipal Investigator

    • Principal Investigator
      FUKUSHIGE Shinichi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Tohoku University
  •  The search for DNA methylation-based biomarkers in cancerPrincipal Investigator

    • Principal Investigator
      FUKUSHIGE Shinichi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Tohoku University
  •  Functional analysis of MBD proteins in epigenetic silencing of cancer-related genesPrincipal Investigator

    • Principal Investigator
      FUKUSHIGE Shinichi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Tohoku University
  •  安定なRNA干渉を可能にするステーブル細胞株作製技術の開発Principal Investigator

    • Principal Investigator
      福重 真一
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Experimental pathology
    • Research Institution
      Tohoku University
  •  Mechanism of transcriptional silencing mediated by the methyl-CpG binding protein MBD4 and RET finger protein

    • Principal Investigator
      KONDO Emiko
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Tohoku University
  •  Functional analysis of DNA mismatch protein hMLH1 using germline mutantsPrincipal Investigator

    • Principal Investigator
      FUKUSHIGE Shinichi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Molecular biology
    • Research Institution
      Tohoku University
  •  Reseearch on Genetic Alterations in the Development and Progression of Human Pancreatic Cancer

    • Principal Investigator
      HORII Akira
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Human pathology
    • Research Institution
      Tohoku University
  •  Genetic alterations involved in initiation and progression of human cancer

    • Principal Investigator
      HORII Akira
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University School of Medicine
  •  Identification of tumor suppressor genes by means of a genomic clone-transfer

    • Principal Investigator
      FURUKAWA Toru
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Tohoku University
  •  Establishment of novel efficient methods for pancreatic cancer patients based on genetic abnormality.

    • Principal Investigator
      MATSUNO Seiki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Digestive surgery
    • Research Institution
      Tohoku Uniersity
  •  環状酵母人工染色体(YAC)移入による癌抑制遺伝子の同定Principal Investigator

    • Principal Investigator
      福重 真一
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Laboratory animal science
    • Research Institution
      Tohoku University
  •  DNA除去修復機構とその修復欠損の分子病態

    • Principal Investigator
      田中 亀代次
    • Project Period (FY)
      1996 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Osaka University
  •  Identification of tumor suppressor genes in human pancreatic cancer

    • Principal Investigator
      HORII Akira
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Human pathology
    • Research Institution
      Tohoku University
  •  Development of chromosome sorting techniques using a dual laser chromosome sorter

    • Principal Investigator
      MATSUBARA Kenichi, 室津 知明
    • Project Period (FY)
      1986 – 1988
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      分子遺伝学・分子生理学
    • Research Institution
      Osaka University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2007 2006 1999 Other

All Journal Article Presentation Book

  • [Book] Biomarkers in Cancer.2015

    • Author(s)
      Fukushige S, Horii A.
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-24590471
  • [Journal Article] TWIST1 is a prognostic factor for neoadjuvant chemotherapy for patients with resectable pancreatic cancer: a preliminary study2023

    • Author(s)
      Fujiwara S, Saiki Y, Fukushige S, Yamanaka M, Ishida M, Motoi F, Unno M, Horii A.
    • Journal Title

      Surg Today

      Volume: 53 Issue: 5 Pages: 633-639

    • DOI

      10.1007/s00595-023-02655-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07211
  • [Journal Article] Long Non-Coding RNAs Associated with Mitogen-Activated Protein Kinase in Human Pancreatic Cancer2023

    • Author(s)
      Ishikawa Tomohiko、Fukushige Shinichi、Saiki Yuriko、Hirose Katsuya、Hiyoshi Takako、Ogawa Takenori、Katori Yukio、Furukawa Toru
    • Journal Title

      Cancers

      Volume: 15 Issue: 1 Pages: 303-303

    • DOI

      10.3390/cancers15010303

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07211, KAKENHI-PROJECT-23K24101
  • [Journal Article] Combination therapy of lymphatic drug delivery and total body irradiation in a metastatic lymph node and lung mouse model2022

    • Author(s)
      Sora Shota、Sukhbaatar Ariunbuyan、Fukushige Shinichi、Mori Shiro、Sakamoto Maya、Kodama Tetsuya
    • Journal Title

      Cancer Science

      Volume: 114 Issue: 1 Pages: 227-235

    • DOI

      10.1111/cas.15562

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07211, KAKENHI-PROJECT-21K18319, KAKENHI-PROJECT-20H00655, KAKENHI-PROJECT-22K18203
  • [Journal Article] Aberrant hypermethylation-mediated suppression of PYCARD is extremely frequent in prostate cancer with Gleason score >=72021

    • Author(s)
      Toshiya Miyauchi, Masahiro Takahashi, Koji Mitsuzuka, Yuriko Saiki, Teppei Okubo, Paula M. Vertino, Akiteru Goto, Yoichi Arai, Akira Horii, and Shinichi Fukushige
    • Journal Title

      Disease Markers

      Volume: 2021 Pages: 1-13

    • DOI

      10.1155/2021/8858905

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07061, KAKENHI-PROJECT-19K07454, KAKENHI-PROJECT-18H03123
  • [Journal Article] Methylation-mediated Silencing of the LIM Homeobox 6 (LHX6) Gene Promotes Cell Proliferation in Human Pancreatic Cancer2020

    • Author(s)
      Yakefujiang Abudurexiti, Zhaodi Gu, Kanchan Chakma, Tatsuo Hata, Fuyuhiko Motoi, Michiaki Unno, Akira Horii, Shinichi Fukushige
    • Journal Title

      Biochem Biophys Res Commun

      Volume: - Issue: 3 Pages: 626-632

    • DOI

      10.1016/j.bbrc.2020.03.120

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07771
  • [Journal Article] Epigenetic inactivation of IRX4 is responsible for acceleration of cell growth in human pancreatic cancer2020

    • Author(s)
      Kanchan Chakma, Zhaodi Gu, Yakefujiang Abudurexiti, Tatsuo Hata, Fuyuhiko Motoi, Michiaki Unno, Akira Hori, Shinichi Fukushige
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 12 Pages: 4594-4604

    • DOI

      10.1111/cas.14644

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07771
  • [Journal Article] Targeted TET oxidase activity through methyl-CpG-binding domain extensively suppresses cancer cell proliferation.2016

    • Author(s)
      Mizuguchi Y, Saiki Y, Horii A, Fukushige S.
    • Journal Title

      Cancer Med

      Volume: 5 Issue: 9 Pages: 2522-2533

    • DOI

      10.1002/cam4.830

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26460468, KAKENHI-PROJECT-15K08392
  • [Journal Article] Technological advances in epigenomics lead to a better understanding of inflammatory diseases, decitabine and H3K27me3.2015

    • Author(s)
      Fukushige S, Horii A
    • Journal Title

      Epigenomics

      Volume: 7 Issue: 2 Pages: 133-136

    • DOI

      10.2217/epi.14.90

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08392, KAKENHI-PROJECT-26460468
  • [Journal Article] S100A4 is frequently overexpressed in lung cancer cells and promotes cell growth and cell motility.2014

    • Author(s)
      Chen N, Sato D, Saiki Y, Sunamura M, Fukushige S, Horii A.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: in press Issue: 3 Pages: 459-464

    • DOI

      10.1016/j.bbrc.2014.04.025

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590452, KAKENHI-PROJECT-24590471, KAKENHI-PROJECT-26460468
  • [Journal Article] DNA Methylation in Cancer: A Gene Silencing Mechanism and the Clinical Potential of Its Biomarkers2013

    • Author(s)
      Fukushige S, Horii A.
    • Journal Title

      Tohoku J. Exp. Med.

      Volume: 229 Issue: 3 Pages: 173-185

    • DOI

      10.1620/tjem.229.173

    • NAID

      10031161717

    • ISSN
      0040-8727, 1349-3329
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590452, KAKENHI-PROJECT-24590471
  • [Journal Article] Suppressed expression of NDRG2 correlates with poor prognosis in pancreatic cancer2013

    • Author(s)
      Yamamura A, et al
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 441(1) Issue: 1 Pages: 102-7

    • DOI

      10.1016/j.bbrc.2013.10.010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390253, KAKENHI-PROJECT-23590452, KAKENHI-PROJECT-24590471, KAKENHI-PUBLICLY-25118720, KAKENHI-PROJECT-25293081, KAKENHI-PROJECT-25462673
  • [Journal Article] DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells. Biochem. Biophys2012

    • Author(s)
      Saiki Y, Yoshino Y, Fujimura H, Manabe T, Kudo Y, Shimada M, Mano N, Nakano T, Lee Y, Shimizu S, Oba S, Fujiwara S, Shimizu H, Chen N, Nezhad ZK, Jin G, Fukushige S, Sunamura M, Ishida M, Motoi F, Egawa S, Unno M, Horii A.
    • Journal Title

      Res. Commun

      Volume: 421巻 Pages: 98-104

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590425
  • [Journal Article] Road to early detection of pancreatic cancer : Attempts to utilize epigenetic biomarkers2012

    • Author(s)
      Shinichi Fukushige
    • Journal Title

      Cancer Lett

      Volume: (未定)(in press) Issue: 2 Pages: 231-237

    • DOI

      10.1016/j.canlet.2012.03.022

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590425, KAKENHI-PROJECT-23590452, KAKENHI-PROJECT-24590471
  • [Journal Article] Road to early detection of pancreatic cancer : Attempts to utilize epigenetic biomarkers2012

    • Author(s)
      Fukushige S, Horii A.
    • Journal Title

      Cancer Lett

      Volume: (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590425
  • [Journal Article] Identification of epigenetically silenced genes in human pancreatic cancer by a novel method"microarray coupled with methyl-CpG targeted transcriptional activation" (MeTA-array)2011

    • Author(s)
      Shimizu H, Horii A, Sunamura M, Motoi F, Egawa S, Unno M, Fukushige S
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 411巻 Pages: 162-167

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590425
  • [Journal Article] Microarray coupled with methyl-CpG targeted transcriptional activation (MeTA-array)identifies hypermethylated genes containing the stringent criteria of CpG islands at high frequency2011

    • Author(s)
      Sato Y, Horii A, Fukushige S
    • Journal Title

      Epigenetics

      Volume: 6巻 Pages: 752-759

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590425
  • [Journal Article] RET finger protein enhances MBD2-and MBD4-dependent transcriptional repression.2006

    • Author(s)
      Fukushige, S.
    • Journal Title

      Biochem. Biophys. Res. Commun. 351

      Pages: 85-92

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390117
  • [Journal Article] RET finger protein enhances MBD2- and MBD4-dependent transcriptional repression.2006

    • Author(s)
      Fukushige, S.
    • Journal Title

      Biochem. Biophys. Res. Commun. 351

      Pages: 85-92

    • Data Source
      KAKENHI-PROJECT-17659111
  • [Journal Article] RET finger protein enhances MBD2・and MBD4-dependent transcriptional repression.2006

    • Author(s)
      Fukushige, S.
    • Journal Title

      Biochem Biophys. Res. Commun. 351

      Pages: 85-92

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590333
  • [Journal Article] RET finger protein enhances MBD2- and MBD4-dependent transcriptional repression.2006

    • Author(s)
      Fukushige, S.
    • Journal Title

      Biochem. Biophys. Res. Commun. 351

      Pages: 85-92

    • Data Source
      KAKENHI-PROJECT-18390117
  • [Journal Article] RET finger protein enhances MBD2- and MBD4-dependent transcriptional repression.2006

    • Author(s)
      Fukushige, S.
    • Journal Title

      Biochem. Biophys. Res. Commun. 351

      Pages: 85-92

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590333
  • [Journal Article] RET finger protein enhances MBD2- and MBD4-dependent transcriptional repression2006

    • Author(s)
      Fukushige, S.
    • Journal Title

      Biochem. Biophys. Res. Commun. 351

      Pages: 85-92

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390117
  • [Journal Article] Cloning and characterization of the human UDP-N-acetylglucosamine : a-1,3-D-mannosideb-1,4-N-acetylglucosaminyltransferase IV-homologue(hGnT-IV-H) gene.1999

    • Author(s)
      Furukawa.T., Youssef, E.M., Yatsuoka, T., Yokoyama, T., Makino, N., Inoue, H., Fukushige, S., Hoshi, M., Hayashi, Y., Sunamura, M., Horii, A.
    • Journal Title

      J.Hum.Genet. 44

      Pages: 397-401

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-10307032
  • [Journal Article] Identification of three commonly deleted regions on chromosome arm 6q in human pancreatic cancer.1999

    • Author(s)
      Abe, T., Makino, N., Furukawa, T, Ouyang, H., Kimura, M., Yatsuoka, T., Yokoyama, T., Inoue, H., Fukushige, S., Hoshi, M., Hayashi, Y., Sunamura, M., Kobari, M., Matsuno, S., Horii.A.
    • Journal Title

      Genes Chromosomes Cancer 25

      Pages: 60-64

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-10307032
  • [Journal Article] Infrequent somatic mutations of the p73 gene in various human cancers.1999

    • Author(s)
      Han, S., Semba, S., Abe, T., Makino, N., Furukawa, T., Fukushige, S., Takahashi, H., Sakurada, A., Sato, M., Shiiba, K., Matsuno, S., Nimura, Y., Nakagawara, A., Horii, A.
    • Journal Title

      Eur.J.Surg.Oncol. 25

      Pages: 194-198

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-10307032
  • [Presentation] アポトーシス誘導遺伝子PYCARDは前立腺癌でDNA高度メチル化により発現抑制される2019

    • Author(s)
      宮内隼弥、高橋正博、大久保鉄平、齋木由利子、三塚浩二、荒井陽一、堀井明、福重真一
    • Organizer
      第108回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-18K07061
  • [Presentation] LHX6はエピジェネティックに不活性化される膵癌の癌抑制遺伝子候補である2019

    • Author(s)
      ヤクブアブドゥリシディ、堀井明、元井冬彦、海野倫明、福重真一
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K07771
  • [Presentation] PYCARDは前立腺癌において異常にメチル化し、発現低下している2019

    • Author(s)
      福重真一、宮内隼弥、高橋正博、齋木由利子、大久保鉄平、三塚浩二、荒井陽一、堀井明
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K07061
  • [Presentation] IRX1の異常メチル化は前立腺癌に高頻度で発生し、増殖を活性化する2019

    • Author(s)
      高橋正博、三塚浩二、伊藤明宏、堀井明、福重真一
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K07061
  • [Presentation] ZNF750 gene promoter is aberrantly methylated in prostate cancer2018

    • Author(s)
      高橋正博、三塚浩二、齋木由利子、堀井明、荒井陽一、福重真一
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K07061
  • [Presentation] 前立腺腫瘍形成においてPYCARD遺伝子プロモーターのメチル化が高頻度に発生する2017

    • Author(s)
      福重真一、宮内隼弥、大久保鉄平、齋木由利子、高橋正博、三塚浩二、荒井陽一、堀井明
    • Organizer
      第76回 日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-15K08392
  • [Presentation] Methylation-mediated silenced PYCARD plays a key role in human prostate cancer2017

    • Author(s)
      Shinichi Fukushige, Toshiya Miyauchi, Teppei Okubo, Koji Mitsuzuka, Yoichi Arai, Akira Horii
    • Organizer
      108th American Association for Cancer Research Annual Meeting: 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08392
  • [Presentation] Targeted TET oxidase activity through methyl-CpG binding domain extensively suppresses cancer cell proliferation.2016

    • Author(s)
      Fukushige S, Mizuguchi Y, Chakma K, Saiki Y, Horii A
    • Organizer
      13th International Congress of Human Genetics
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2016-04-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08392
  • [Presentation] Targeted TET oxidase activity through methyl-CpG binding domain extensively suppresses cancer cell proliferation.2016

    • Author(s)
      Fukushige S, Mizuguchi Y, Chakma K, Saiki Y, Horii A
    • Organizer
      107th American Association for Cancer Research Annual Meeting
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2016-04-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08392
  • [Presentation] DNMT-independent reactivation of hypermethylated genes induces growth suppression and apoptosis in LNCaP cells2015

    • Author(s)
      福重真一、宮内隼也、堀井明
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-15K08392
  • [Presentation] TET1蛋白のヒドロキシラーゼ活性はエピジェネティックに転写抑制された遺伝子の再活性化を引き起こす2013

    • Author(s)
      福重真一、水口康彦、堀井明
    • Organizer
      第72回 日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-24590471
  • [Presentation] S100A4の下流で制御されるIFI27、NOVの膵癌の発生、進展における役割の解析2013

    • Author(s)
      陳娜、齋木由利子、砂村真琴、福重真一、元井冬彦、江川新一、海野倫明、堀井明
    • Organizer
      第72回 日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-24590471
  • [Presentation] MeTA-array, a useful method to identify genes transcriptionally silenced by tumor-specific hypermethylation in cancer.2013

    • Author(s)
      Fukushige S, Horii A
    • Organizer
      104th American Association for Cancer Research Annual Meeting
    • Place of Presentation
      Washington DC, USA
    • Data Source
      KAKENHI-PROJECT-24590471
  • [Presentation] MeTA-array, a useful method to identify genes transcriptionally silenced by tumor-specific hypermethylation in cancer.2013

    • Author(s)
      Shinichi Fukushige
    • Organizer
      American Association for Cancer Research Annual Meeting 2013
    • Place of Presentation
      Washington DC, USA
    • Data Source
      KAKENHI-PROJECT-24590471
  • [Presentation] ヒト癌において腫瘍特異的な高度メチル化により転写抑制された遺伝子のMeTA-arrayによる効率的探索法の開発2012

    • Author(s)
      福重真一
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-24590471
  • [Presentation] 大腸癌における新規癌抑制遺伝子NDRG2のエピジェネティックな発癌制御機構2011

    • Author(s)
      山村明寛、堀井明、三浦康、阿部佳子、内藤剛、小川仁、矢崎伸樹、羽根田祥、渡辺和宏、大沼忍、佐瀬友彦、鈴木秀幸、斉木由利子、福重真一、柴田近、佐々木巌
    • Organizer
      第74回大腸癌研究会
    • Place of Presentation
      福岡
    • Year and Date
      2011-01-21
    • Data Source
      KAKENHI-PROJECT-21590425
  • [Presentation] メチルCpG配列を標的とする転写活性化とマイクロアレイの組み合わせはヒトがんにおける低メチル化遺伝子の同定を可能にする2011

    • Author(s)
      福重真一、陳娜、堀井明
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
    • Data Source
      KAKENHI-PROJECT-21590425
  • [Presentation] S100A4 regulates tumor growth, motility, and invasion in pancreatic cancer2011

    • Author(s)
      Sekine H, Tabata T, Tsukamoto N, Chen N, Sato K, Umetsu Y, Nakamura K, Kim G, Yamamura A, Yoshino Y, Fukushige S, Sunamura M, Horii A.
    • Organizer
      60th Annual Meeting of the American Society of Human Genetics
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-01-03
    • Data Source
      KAKENHI-PROJECT-21590425
  • [Presentation] S100A4 regulates tumor growth, motility, and invasion in pancreatic cancer2010

    • Author(s)
      Sekine H, Tabata T, Tsukamoto N, Yamamura A, Abe K, Yoshino Y, Sato K, Chen N, Umetsu Y, Sato D, Gu Z, Fukushige S, Shima K, Motoi F, Egawa S, Sunamura M, Horii A.
    • Organizer
      101st American Association for Cancer Research Annual Meeting
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2010-04-21
    • Data Source
      KAKENHI-PROJECT-21590425
  • [Presentation] ヒトがんにおいて各メチルCpG結合ドメインは異なるメチル化遺伝子を標的とする能力をもっ2010

    • Author(s)
      福重真一
    • Organizer
      第69回 日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Data Source
      KAKENHI-PROJECT-21590425
  • [Presentation] ヒトがんにおいて各メチルCpG結合ドメインは異なるメチル化遺伝子を標的とする能力をもつ2010

    • Author(s)
      福重真一、堀井明
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Data Source
      KAKENHI-PROJECT-21590425
  • [Presentation] Identification of novel targets for aberrant methylation in pancreatic cancer by a newly developed method"methyl-CpG targeted transcriptional activation (MeTA)2010

    • Author(s)
      Fukushige S, Shimizu H, Sato Y, Horii A.
    • Organizer
      101st American Association for Cancer Research Annual Meeting
    • Place of Presentation
      Washington DC, USA.
    • Year and Date
      2010-04-18
    • Data Source
      KAKENHI-PROJECT-21590425
  • [Presentation] 癌抑制遺伝子NDRG2のエピジェネティックサイレンシングは消化器発癌を進行させる2010

    • Author(s)
      山村明寛、三浦康、木内誠、安藤敏典、矢崎伸樹、田中直樹、唐澤秀明、佐瀬友彦、木村俊一、福重真一、Zhaodi Gu、嶋健太郎、柴田近、堀井明、佐々木巌
    • Organizer
      第110回日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-04-08
    • Data Source
      KAKENHI-PROJECT-21590425
  • [Presentation] メチル化で発現抑制された遺伝子を特定する新規の方法「MeTA」の膵癌解析への応用2010

    • Author(s)
      清水秀幸、福重真一、堀井明
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-29
    • Data Source
      KAKENHI-PROJECT-21590425
  • [Presentation] Expression of the N-myc downstream-regulated gene 2 (NDRG2)is frequently suppressed by promoter hypermethylation in human gastrointestinal and pancreatic cancers2010

    • Author(s)
      Yamamura A, Miura K, Karasawa H, Abe K, Mizuguchi Y, Jin G, Gu Z, Fukushige S, Kaneko N, Kinouchi M, Ando T, Yazaki N, Tanaka N, Sase T, Shibata C, Sasaki I, Horii A.
    • Organizer
      101st American Association for Cancer Research Annual Meeting
    • Place of Presentation
      Washington DC, USA.
    • Year and Date
      2010-04-21
    • Data Source
      KAKENHI-PROJECT-21590425
  • [Presentation] 癌抑制遺伝子NDRG2のエピジェネティックサイレンシングは消化器発癌を進行させる2010

    • Author(s)
      山村明寛、三浦康、阿部佳子、福重真一、斉木由利子、木内誠、安藤敏典、唐澤秀明、金子直征、佐瀬友彦、柴田近、佐々木巌、堀井明
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
    • Data Source
      KAKENHI-PROJECT-21590425
  • [Presentation] 消化器癌においてNDRG2はプロモーターのメチル化によって発現抑制される2009

    • Author(s)
      山村明寛、三浦康、木内誠、安藤敏典、矢崎伸樹、田中直樹、唐澤秀明、佐瀬友彦、福重真一、Zhaodi Gu、柴田近、佐々木巌、堀井明
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Data Source
      KAKENHI-PROJECT-21590425
  • [Presentation] メチルCpG配列を標的とする転写再活性化は、高度DNAメチル化で転写抑制された遺伝子の高感度かつ高精度な同定を可能にする2009

    • Author(s)
      佐藤裕子、堀井明、福重真一
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
    • Data Source
      KAKENHI-PROJECT-21590425
  • [Presentation] メチルCpG配列を標的とする転写再活性化による膵がんにおいてエピジェネティックに転写抑制された遺伝子の同定2009

    • Author(s)
      福重真一、堀井明
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Data Source
      KAKENHI-PROJECT-21590425
  • [Presentation] S100A4は膵癌細胞の増殖と浸潤を制御する2009

    • Author(s)
      関根均、塚本信和、田畑孝洋、吉野優樹、梅津有紀子、Gu Zhaodi、佐藤大亮、嶋健太郎、福重真一、元井冬彦、江川新一、砂村眞琴、堀井明
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Data Source
      KAKENHI-PROJECT-21590425
  • [Presentation] メチルCpG配列を標的とする転写再活性化による膵がんにおいてテピジェネティックに転写抑制された遺伝子の同定2009

    • Author(s)
      福重真一
    • Organizer
      第68回 日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Data Source
      KAKENHI-PROJECT-21590425
  • [Presentation] Changes in histone modifications reactivate the expression of epigenetically silenced tumor suppressor genes2007

    • Author(s)
      Shinichi Fukushige
    • Organizer
      66^<th> Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-10-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390117
  • [Presentation] Changes in histone modifications reactivate the expression of epigenetically silenced tumor suppressor genes in cancer cells2007

    • Author(s)
      Shinichi Fukushige
    • Organizer
      The American Society of Human Genetics 57th Annual Meeting
    • Place of Presentation
      アメリカ合衆国、San Diego
    • Year and Date
      2007-10-26
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390117
  • [Presentation] Changes in histone modifications reactivate the expression of epigenetically silenced tumor suppressor genes2007

    • Author(s)
      Shinichi Fukushige
    • Organizer
      第66回 日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390117
  • [Presentation] がん抑制遺伝子のエピジェネティックサイレンシングはヒストン修飾の改変によって再活性化される2007

    • Author(s)
      福重 真一
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-13
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390117
  • [Presentation] Changes in histone modifications reactivate the expression of epigenetic ally silenced tumor suppressor genes in cancer cells2007

    • Author(s)
      Shinichi Fukushige
    • Organizer
      The American Society of Human Genetics 57th Annual Meeting
    • Place of Presentation
      アメリカ合衆国、San Diego
    • Year and Date
      2007-10-26
    • Data Source
      KAKENHI-PROJECT-18390117
  • [Presentation] The alterations in histone modifications reactivate the expression of epigenetically silenced tumor suppressor genes2007

    • Author(s)
      Shinichi Fukushige
    • Organizer
      The 30^<th> Annual Meeting of the Molecular Biology Society of Japan/The 80^<th> Annual Meeting of the Japanese Biochemical Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-12-13
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390117
  • [Presentation] Changes in histone modifications reactivate the expression of epigenetically silenced tumor suppressor genes in cancer cells2007

    • Author(s)
      Shinichi Fukushige
    • Organizer
      The American Society of Human Genetics 57th Annual Meeting
    • Place of Presentation
      San Diego
    • Year and Date
      2007-10-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390117
  • [Presentation] Ret finger protein mediates MBD2-and MBD4-dependent transcriptional repression2006

    • Author(s)
      Shinichi Fukushige
    • Organizer
      97th American Association for Cancer Research Annual Meeting
    • Place of Presentation
      アメリカ合衆国、Washington DC
    • Year and Date
      2006-04-02
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390117
  • [Presentation] GSTP1遺伝子の再発現におけるヒストン脱アセチル化酵素阻害の役割2006

    • Author(s)
      福重 真一
    • Organizer
      第65回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2006-09-28
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390117
  • [Presentation] Ret finger protein mediates MBD2- and MBD4-dependent transcriptional repression2006

    • Author(s)
      Shinichi Fukushige
    • Organizer
      97^<th> American Association for Cancer Research Annual Meeting
    • Place of Presentation
      Washington DC
    • Year and Date
      2006-04-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390117
  • [Presentation] The role of histone deacetylase inhibition in the re-expression of GSTP1 gene2006

    • Author(s)
      Shinichi Fukushige
    • Organizer
      65^<th> Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-09-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390117
  • [Presentation] S100A4 is frequently overexpressed in lung cancer cells and promotes cell motility.

    • Author(s)
      陳 娜、齋木 由利子、砂村 真琴、福重 真一、堀井 明
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-24590471
  • [Presentation] Methyl-CpG targeted DNA demethylation by TET hydroxylase activity suppresses the growth of cancer cells.

    • Author(s)
      福重 真一、齋木 由利子、堀井 明
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-24590471
  • [Presentation] IFI27 and NOV, downstream regulated genes by S100A4, are playing important roles in pancreatic carcinogenesis.

    • Author(s)
      Chen N, Saiki Y, Sekine H, Sunamura M, Fukushige S, Motoi F, Egawa S, Unno M, Hroii A
    • Organizer
      105th American Association for Cancer Research Annual Meeting
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2014-04-05 – 2014-04-09
    • Data Source
      KAKENHI-PROJECT-24590471
  • [Presentation] TET oxidase activity accumulated on methyl-CpG sites extensively upregulates methylated genes through DNA demethylation.

    • Author(s)
      Fukushige S, Mizuguchi Y, Horii A
    • Organizer
      105th American Association for Cancer Research Annual Meeting
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2014-04-05 – 2014-04-09
    • Data Source
      KAKENHI-PROJECT-24590471
  • 1.  HORII Akira (40249983)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 5 results
  • 2.  SUNAMURA Makoto (10201584)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 3.  SHIBUYA Kazuhiko (70260429)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  FURUKAWA Toru (30282122)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 5.  MATSUBARA Kenichi (20037394)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  MATSUNO Seiki (80004737)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 7.  HOSHI Masato (20323008)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  KONDO Emiko (20374928)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  OCHIYA Takahiro (60192530)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  Gu Zhaodi (40451520)
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    # of Collaborated Products: 2 results
  • 11.  田中 亀代次 (80144450)
    # of Collaborated Projects: 1 results
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  • 12.  関 周司 (50032884)
    # of Collaborated Projects: 1 results
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  • 13.  安井 明 (60191110)
    # of Collaborated Projects: 1 results
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  • 14.  花岡 文雄 (50012670)
    # of Collaborated Projects: 1 results
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  • 15.  山泉 克 (70107093)
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