SUZUKI Nobuchika 鈴木信周

Researcher Number	90247007
Affiliation (based on the past Project Information) *help	2017: 日本医科大学, 付置研究所, 研究生 2017: 日本医科大学, 大学院医学研究科, 研究生 2009 – 2016: 東京大学, 先端科学技術研究センター, 特任助教 2014 – 2015: 東京大学, 先端科学技術研究センター, 助教 2009: The University of Tokyo, 先端科学技術センター, 特任助教
Review Section/Research Field	Principal Investigator Pediatrics Except Principal Investigator General pharmacology / Kidney internal medicine
Keywords	Principal Investigator RH-RhoGEF / リン酸化修飾 / リン酸化 / 分化 / 白血病細胞 / TGFβ / G12 / Rho / 平滑筋細胞分化 / Rho活性化調節 … More / Gα12/13 / Ggamma / Gbeta / 三量体G蛋白質G12 / 血管平滑筋細胞分化 / 三量体G蛋白 / 平滑筋分化 / 核移行 / 核エンベロープ / 白血病 / Rho活性化因子 / 核膜 / 細胞分化 / ショットガンプロテオミクス / G蛋白質 / 小児血液学 … More Except Principal Investigator Rho / シグナル伝達 / 癌細胞 / G蛋白質 / 高リン血症 / 高カリウム血症 / 低カルシウム血症 / 腎電解質代謝 / カルシウム感知受容体 / 遺伝子治療3 / 遺伝子治療 / 骨異栄養症 / 慢性腎不全 / 低Ca血症 / 腎電解質異常 / Ca感知受容体 / 副甲状腺機能低下症 / 腎機能低下 / カルシウム代謝 / バーター症候群 Less

The role of the heterotrimeric G protein, Galpha12/13 in differentiation and proliferation of smooth muscle cells.Principal Investigator
- Principal Investigator
  
  Suzuki Nobuchika
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nippon Medical School
  The University of Tokyo
the mechanism of RH-RhoGEF activation by G12/13
- Principal Investigator
  
  KOZASA Tohru
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  The University of Tokyo
p115RhoGEF promote differentiation of human acute leukemic cellsPrincipal Investigator
- Principal Investigator
  
  Suzuki Nobuchika
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The University of Tokyo
The function of LARG in the nucleusPrincipal Investigator
- Principal Investigator
  
  SUZUKI Nobuchika
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The University of Tokyo
Where is the cause of Bartter's syndrome in the kidney?
- Principal Investigator
  
  WATANABE Sumiyo
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo

All 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Other

[Journal Article] Mitotic-dependent phosphorylation of leukemia-associated RhoGEF (LARG) by Cdk12015
- Author(s)
  Helms, M. C. Grabocka, E. Martz, M. K. Fischer, C. C. Suzuki, N. Wedegaertner, P. B.
- Journal Title
  
  Cell Signal
  
  Volume: 28 Issue: 1 Pages: 43-52
- DOI
  10.1016/j.cellsig.2015.10.004
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09683, KAKENHI-PROJECT-24591540
[Journal Article] Gα13/PDZ-RhoGEF/RhoA signaling is essential for gastrin-releasing peptide receptor-mediated colon cancer cell migration.2014
- Author(s)
  Patel M, Kawano T, Suzuki N, Hamakubo T, Karginov AV, Kozasa T.
- Journal Title
  
  Mol Pharmacol
  
  Volume: 86 Issue: 3 Pages: 252-262
- DOI
  10.1124/mol.114.093914
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24108007, KAKENHI-PROJECT-24390060, KAKENHI-PROJECT-24591540, KAKENHI-PROJECT-25220205
[Journal Article] G protein-dependent basal and evoked endothelial cell vWF secretion.2014
- Author(s)
  Rusu L, Andreeva A, Visintine DJ, Kim K, Vogel SM, Stojanovic-Terpo A, Chernaya O, Liu G, Bakhshi FR, Haberichter SL, Iwanari H, Kusano-Arai O, Suzuki N, Hamakubo T, Kozasa T, Cho J, Du X, Minshall RD.
- Journal Title
  
  Blood
  
  Volume: 123 Issue: 3 Pages: 442-450
- DOI
  10.1182/blood-2013-03-489351
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-24108007, KAKENHI-PROJECT-24390060, KAKENHI-PROJECT-24591540, KAKENHI-PROJECT-25220205
[Journal Article] GPCRシグナルの動的作用機構の解明―タンパク質表面のインターフェースに注目した、新たな熱力学的解析2013
- Author(s)
  鈴木信周、小笹徹。
- Journal Title
  
  実験医学
  
  Volume: 31 Pages: 399-405
- Data Source
  KAKENHI-PROJECT-24591540
[Journal Article] Modification of p115RhoGEF Ser(330) regulates its RhoGEF activity.2013
- Author(s)
  CHOW, C. R., SUZUKI, N., KAWAMURA, T., HAMAKUBO, T. & KOZASA, T.
- Journal Title
  
  Cell Signal
  
  Volume: 25 Issue: 11 Pages: 2085-92
- DOI
  10.1016/j.cellsig.2013.06.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591540, KAKENHI-PROJECT-25220205
[Journal Article] A method of generating antibodies against exogenously administered self-antigen by manipulating CD4+CD25+ regulatory T cells.2011
- Author(s)
  IWANARI, H., NAKADA-NAKURA, Y., KUSANO-ARAI, O., SUZUKI, N., KODAMA, T., SAKIHAMA, T. & HAMAKUBO, T.
- Journal Title
  
  J Immunol Methods
  
  Volume: 369 Pages: 108-14
- Data Source
  KAKENHI-PROJECT-21591348
[Journal Article] Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13.2011
- Author(s)
  KOZASA, T., HAJICEK, N., CHOW, C. R. & SUZUKI, N.
- Journal Title
  
  J Biochem
  
  Volume: 150 Pages: 357-69
- NAID
  10030587857
- Data Source
  KAKENHI-PROJECT-21591348
[Journal Article] Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G132011
- Author(s)
  Kozasa T, Hajicek N, Chow CR, Suzuki N
- Journal Title
  
  J Biochem
  
  Volume: 150 Issue: 4 Pages: 357-369
- DOI
  10.1093/jb/mvr105
- NAID
  10030587857
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591348
[Journal Article] A method of generating antibodies against exogenously administered self-antigen by manipulating CD4+CD25+ regulatory T cells2011
- Author(s)
  Iwanari H
- Journal Title
  
  J Immunol Method
  
  Volume: Jun30 ; 369(1-2) Issue: 1-2 Pages: 108-14
- DOI
  10.1016/j.jim.2011.04.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20221010, KAKENHI-PROJECT-21591348
[Journal Article] Regulation and physiological functions of G12/13-mediated signaling pathways.2009
- Author(s)
  SUZUKI, N., HAJICEK, N. & KOZASA, T.
- Journal Title
  
  Neurosignals
  
  Volume: 17 Pages: 55-70
- Data Source
  KAKENHI-PROJECT-21591348
[Journal Article] Activation of leukemia-associated RhoGEF by Galpha13 with significant conformational rearrangements in the interface.2009
- Author(s)
  SUZUKI, N., TSUMOTO, K., HAJICEK, N., DAIGO, K., TOKITA, R., MINAMI, S., KODAMA, T., HAMAKUBO, T. & KOZASA, T.
- Journal Title
  
  J Biol Chem
  
  Volume: 284 Pages: 5000-9
- Data Source
  KAKENHI-PROJECT-21591348
[Presentation] Cdk1-dependent phosphorylation of leukemia-associated RhoGEF during mitosis2014
- Author(s)
  M.C. Helms, E. Grabocka, M.K. Martz, N. Suzuki and P.B. Wedegaertner
- Organizer
  Experimental Biology
- Place of Presentation
  San Diego Convention center, USA
- Year and Date
  2014-04-28
- Data Source
  KAKENHI-PROJECT-24591540
[Presentation] The role of p115RhoGEF during differentiation of human myeloid HL60 leukemia cells2012
- Author(s)
  Nobuchika Suzuki, Takeshi Kawamura, Hiroko Iwanari, Takao Hamakubo, Tohru Kozasa
- Organizer
  Gordon Research Conference
- Place of Presentation
  Univ of New England, USA
- Data Source
  KAKENHI-PROJECT-24591540
[Presentation] The role of the G13～RH-RhoGEF signal pathway in differentiation of human myeloid HL60 leukemia cells2010
- Author(s)
  鈴木信周
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21591348
[Presentation] p115RH-RhoGEF targets lamin B to promote the differentiation of human leukemic cells
- Author(s)
  SUZUKI, N., KAWAMURA, T., HAJICEK, T, HAMAKUBO, T. & KOZASA, T
- Organizer
  Gordon Research Conference
- Place of Presentation
  University of New England, Biddeford, ME, USA
- Year and Date
  2014-06-15 – 2014-06-20
- Data Source
  KAKENHI-PROJECT-24591540
[]

1. KOZASA Tohru (70202059)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
2. KAWAMURA Takeshi (70306835)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
3. IKEDA Tosiyuki (80322759)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. OGASAWARA Toru (20359623)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. UCHIDA Shunya (50151882)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. WATANABE Sumiyo (30422314)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SAITO Taku (30456107)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HONDA Zenitiro (70238814)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. CHANG Kyungho

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. IWANARI Hiroko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 浜窪隆雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

SUZUKI Nobuchika 鈴木 信周

Research Projects

Research Products

Co-Researchers

The role of the heterotrimeric G protein, Galpha12/13 in differentiation and proliferation of smooth muscle cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

the mechanism of RH-RhoGEF activation by G12/13

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

p115RhoGEF promote differentiation of human acute leukemic cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The function of LARG in the nucleusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Where is the cause of Bartter's syndrome in the kidney?

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Mitotic-dependent phosphorylation of leukemia-associated RhoGEF (LARG) by Cdk12015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gα13/PDZ-RhoGEF/RhoA signaling is essential for gastrin-releasing peptide receptor-mediated colon cancer cell migration.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] G protein-dependent basal and evoked endothelial cell vWF secretion.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GPCRシグナルの動的作用機構の解明―タンパク質表面のインターフェースに注目した、新たな熱力学的解析2013

Author(s)

Journal Title

Data Source

[Journal Article] Modification of p115RhoGEF Ser(330) regulates its RhoGEF activity.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A method of generating antibodies against exogenously administered self-antigen by manipulating CD4+CD25+ regulatory T cells.2011

Author(s)

Journal Title

Data Source

[Journal Article] Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13.2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G132011

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] A method of generating antibodies against exogenously administered self-antigen by manipulating CD4+CD25+ regulatory T cells2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation and physiological functions of G12/13-mediated signaling pathways.2009

Author(s)

SUZUKI Nobuchika 鈴木信周