Saito Yoshimasa 齋藤義正

… Alternative Names

SAITO Yoshimasa 齋藤義正

斎藤義正サイトウヨシマサ

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Researcher Number	90360114
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 薬学部(芝共立), 教授 2025: 北里大学, 北里研究所病院, 研究員
Affiliation (based on the past Project Information) *help	2020 – 2024: 慶應義塾大学, 薬学部(芝共立), 教授 2016 – 2019: 慶應義塾大学, 薬学部(芝共立), 准教授 2017: 慶応大学, 薬学部・薬学研究科, 准教授 2011 – 2016: 慶應義塾大学, 薬学部, 准教授 2010: Keio University, 医学部, 共同研究員 … More 2007 – 2009: Keio University, 医学部, 助教 2004: 慶應大, 医学部, 助手 2003: 慶應義塾大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Medium-sized Section 90:Biomedical engineering and related fields / Tumor diagnostics / Pathological medical chemistry / Basic Section 90120:Biomaterials-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Applied health science / Clinical oncology / Gastroenterology Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related … More / Basic Section 49020:Human pathology-related / Chemical biology / Gastroenterology / Biomedical engineering/Biological material science Less
Keywords	Principal Investigator オルガノイド / 胆道がん / 膵臓がん / オルガノイド培養 / DNAメチル化 / 胆道・膵臓がん / エピゲノム / マイクロRNA / エピジェネティクス / 胃がん … More / エピジェネティック治療 / ヒストン修飾 / 抗真菌薬 / 老化 / 幹細胞 / 個別化治療 / ライブラリー / デザイナーエクソソーム / 腫瘍微小環境 / 抗加齢 / NAD+ / がんの個性診断 / 既存薬 / ドラッグリポジショニング / ドラッグ・リポジショニング / 腸管上皮 / ステムセルエイジング / 腸管上皮幹細胞 / エピゲノム変化 / 加齢 / 癌 / がん幹細胞 / ヒストン脱アセチル化酵素阻害薬 / DNAメチル化阻害薬 / 機能性ディスペプシア / Helicobacter pylori / 機能性消化管障害 / H.pylori / microRNA / WAF1遺伝子 / p21 / 肝細胞がん … More Except Principal Investigator マイクロRNA / 細胞外小胞 / 膵がん / CRISPR/Cas9 / 膵臓がん / Multi-omics analysis / Epigenome / DNA methylation / NASH / Hepatocellular carcinoma / 再生医療 / 化合物ライブラリ / 高置換 / CLiP / ヒト肝細胞 / シトクロームP450 / 肝細胞 / 低分子化合物 / リプログラミング / 肝前駆細胞 / 肝細胞移植 / トリコマイシンA / スベロイルアニリドヒドロキサム酸 / miR-122 / apolipoprotein-A1 / osteopontin / レプリコン細胞 / エピジェネティクス / ヒストン修飾 / HCV / 培養細胞株 / EZH2 / Nrf2 / 肝細胞癌 / C型肝炎ウイルス / microRNA / ヒストン脱アセチル化酵素阻害薬 / エピゲノム変化 / 担癌動物 / 癌遺伝子 / 食道腺癌 / 癌幹細胞 / NOGマウス / 5-FU / シスプラチン / 胃癌 / 細胞内導入 / 担がん動物 / 胃がん / がん遺伝子 / アパタイトナノキャリア Less

Multi-omics analysis - particularly epigenomic analysis - to elucidate the nature of NASH-derived hepatocellular carcinoma and identify therapeutic targets
- Principal Investigator
  
  金井弥栄
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Keio University
胆道がん腫瘍微小環境の再構築による次世代オルガノイドの開発Principal Investigator
- Principal Investigator
  
  齋藤義正
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Keio University
デザイナーエクソソームとオルガノイドを用いた個別化がん免疫療法の開発Principal Investigator
- Principal Investigator
  
  齋藤義正
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Keio University
国際協力による難治性がんオルガノイドライブラリーの構築Principal Investigator
- Principal Investigator
  
  齋藤義正
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Keio University
Comprehensive elucidation of the mechanism of circulating miRNA fluctuations during pancreatic carcinogenesis
- Principal Investigator
  
  松崎潤太郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Keio University
Discovery of novel therapeutic agents for biliary tract and pancreatic cancer based on antifungal agentsPrincipal Investigator
- Principal Investigator
  
  Yoshimasa Saito
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Keio University
Elucidation of Aging Mechanisms by Regulation of NAD+ and Epigenome and Development of New Anti-Aging InterventionsPrincipal Investigator
- Principal Investigator
  
  Saito Yoshimasa
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Keio University
Development of biliary and pancreatic tumor cell bank using organoid culture and its application to personalized therapyPrincipal Investigator
- Principal Investigator
  
  Saito Yoshimasa
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor diagnostics
- Research Institution
  Keio University
Investigation of the molecular mechanism underlying aging based on epigenome alterations in intestinal epithelial stem cellsPrincipal Investigator
- Principal Investigator
  
  SAITO Yoshimasa
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied health science
- Research Institution
  Keio University
Generation of hepatic progenitor cells from human hepatocytes using small molecules
- Principal Investigator
  
  KATSUDA Takeshi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical biology
- Research Institution
  National Cancer Center Japan
Diagnostic and therapeutic strategies targeting microRNAs and epigenome alterations in biliary tract and pancreatic cancer stem cellsPrincipal Investigator
- Principal Investigator
  
  Saito Yoshimasa
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor diagnostics
- Research Institution
  Keio University
Analysis of epigenetic changes in hepatocellular carcinoma and an investigation for a new therapeutic modality targeting histone acetylation
- Principal Investigator
  
  SAITO Hidetsugu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
Identification of critical microRNAs in gastric cancer and application for epigenetic therapy.Principal Investigator
- Principal Investigator
  
  SAITO Yoshimasa
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Clinical oncology
- Research Institution
  Keio University
The microRNAsfor the diagnosis and treatment of uppergastro-intestinal malignancy - application of appatite-nanocarrier -
- Principal Investigator
  
  SUZUKI Hidekazu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Keio University
Epigenetic therapy for gastric cancer by targeting microRNAsPrincipal Investigator
- Principal Investigator
  
  SAITO Yoshimasa
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Keio University
Development of a novel strategy for the prevention and treatment of gastric cancer through epigenetic regulation of microRNAsPrincipal Investigator
- Principal Investigator
  
  SAITO Yoshimasa
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Keio University
肝発がん過定におけるインターフェロン-γプロモーター領域メチル化異常の意義Principal Investigator
- Principal Investigator
  
  斎藤義正
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University

[Book] MicroRNAs in Gastric Cancer. In "MicroRNAs in Cancer Translational Research"2011
- Author(s)
  Hidekazu Suzuki, Yoshimasa Saito, 他
- Publisher
  Springer Science(印刷中)
- Data Source
  KAKENHI-PROJECT-21790327
[Book] Chapter 5: MicroRNAs in Gastric Cancer. MicroRNAs in Cancer Translational Research2011
- Author(s)
  Suzuki, H., Saito, Y., Hibi, T.(eds.) William C.S. Cho
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-22300169
[Book] MicroRNAs in Gastric Cancer. In MicroRNAs in Cancer Translational Research. (William C.S. Cho(ed))
- Author(s)
  Suzuki H, Saito Y, Hibi T.
- Publisher
  Springer Science (in press).
- Data Source
  KAKENHI-PROJECT-21790327
[Journal Article] Intestinal metabolites predict treatment resistance of patients with depression and anxiety2024
- Author(s)
  Matsuzaki Juntaro、Kurokawa Shunya、Iwamoto Chiaki、Miyaho Katsuma、Takamiya Akihiro、Ishii Chiharu、Hirayama Akiyoshi、Sanada Kenji、Fukuda Shinji、Mimura Masaru、Kishimoto Taishiro、Saito Yoshimasa
- Journal Title
  
  Gut Pathogens
  
  Volume: 16 Issue: 1 Pages: 8-8
- DOI
  10.1186/s13099-024-00601-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24188
[Journal Article] Plasma extracellular vesicle microRNAs reflecting the therapeutic effect of the CBP/β-catenin inhibitor PRI-724 in patients with liver cirrhosis.2024
- Author(s)
  Yoshida M, Matsuzaki J, Fujita K, Kimura M, Umezu T, Tokuda N, Yamaguchi T, Kuroda M, Ochiya T, Saito Y, Kimura K.
- Journal Title
  
  Sci Rep.
  
  Volume: 14(1) Issue: 1 Pages: 6266-6266
- DOI
  10.1038/s41598-024-56942-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07133, KAKENHI-PROJECT-21H02706, KAKENHI-PROJECT-23K24188
[Journal Article] Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance2023
- Author(s)
  Calvisi Diego F.、Boulter Luke、Vaquero Javier、Saborowski Anna、Fabris Luca、Rodrigues Pedro M.、Coulouarn Cedric、Castro Rui E.、Segatto Oreste、Raggi Chiara、van der Laan Luc J. W.、・・・Saito Yoshimasa、CCA Model Consortium
- Journal Title
  
  Nature Reviews Gastroenterology & Hepatology
  
  Volume: - Issue: 7 Pages: 462-480
- DOI
  10.1038/s41575-022-00739-y
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03533
[Journal Article] Hepatobiliary tumor organoids for personalized medicine: a multicenter view on establishment, limitations and future directions.2022
- Author(s)
  van Tienderen GS*, Li L*, Broutier L*, Saito Y*, Inacio P, Huch M, Selaru FM, van der Laan LJW, Verstegen MMA.（*共同筆頭著者）
- Journal Title
  
  Cancer Cell
  
  Volume: 40 Issue: 3 Pages: 226-230
- DOI
  10.1016/j.ccell.2022.02.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03533
[Journal Article] Challenges for Better Diagnosis and Management of Pancreatic and Biliary Tract Cancers Focusing on Blood Biomarkers: A Systematic Review2021
- Author(s)
  Tominaga Hiroto、Matsuzaki Juntaro、Oikawa Chihiro、Toyoshima Kensho、Manabe Haruki、Ozawa Eriko、Shimamura Atsushi、Yokoyama Riko、Serizawa Yusuke、Ochiya Takahiro、Saito Yoshimasa
- Journal Title
  
  Cancers
  
  Volume: 13 Issue: 16 Pages: 4220-4220
- DOI
  10.3390/cancers13164220
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09471, KAKENHI-PROJECT-20H03533
[Journal Article] 腸管上皮オルガノイドを用いたステムセルエイジング研究2020
- Author(s)
  齋藤義正
- Journal Title
  
  ファルマシア
  
  Volume: 56 Pages: 994-998
- NAID
  130007933945
- Data Source
  KAKENHI-PROJECT-19K22818
[Journal Article] An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping2020
- Author(s)
  Kawasaki K、Toshimitsu K、Matano M、Fujita M、Kudo Atsushi、Kitagawa Y、Kanai T、Nakagawa H、Sato T, et.al.
- Journal Title
  
  Cell
  
  Volume: 183 Issue: 5 Pages: 1420-1435
- DOI
  10.1016/j.cell.2020.10.023
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09041, KAKENHI-PROJECT-20K08340, KAKENHI-PROJECT-17H06176, KAKENHI-PROJECT-18H04049, KAKENHI-PROJECT-20H03533, KAKENHI-PROJECT-20H03746, KAKENHI-PROJECT-20H03757, KAKENHI-PROJECT-18J21346, KAKENHI-PROJECT-20J12287, KAKENHI-PROJECT-23K20316
[Journal Article] Establishment and Long-Term Culture of Organoids Derived from Human Biliary Tract Carcinoma.2020
- Author(s)
  Saito Y, Muramatsu T, Saito H.
- Journal Title
  
  STAR Protocols
  
  Volume: 1 Issue: 1 Pages: 100009-100009
- DOI
  10.1016/j.xpro.2019.100009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03533
[Journal Article] Glucose Depletion Enhances the Stem Cell Phenotype and Gemcitabine Resistance of Cholangiocarcinoma Organoids through AKT Phosphorylation and Reactive Oxygen Species.2019
- Author(s)
  Yoshikawa N, Saito Y, Manabe H, Nakaoka T, Uchida R, Furukawa R, Muramatsu T, Sugiyama Y, Kimura M, Saito H.
- Journal Title
  
  Cancers
  
  Volume: 11 Issue: 12 Pages: 1993-1993
- DOI
  10.3390/cancers11121993
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03592
[Journal Article] Circulating microRNA-1246 as a possible biomarker for early tumor recurrence of hepatocellular carcinoma.2019
- Author(s)
  Chuma M, Toyoda H, Matsuzaki J, Saito Y, Kumada T, Tada T, Kaneoka Y, Maeda A, Yokoo H, Ogawa K, Kamiyama T, Taketomi A, Matsuno Y, Yazawa K, Takeda K, Kunisaki C, Ogushi K, Moriya S, Hara K, Nozaki A, Kondo M, Fukuda H, Numata K, Tanaka K, Maeda S, Sakamoto N.
- Journal Title
  
  Hepatology Research
  
  Volume: 49 Issue: 7 Pages: 810-822
- DOI
  10.1111/hepr.13338
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03592
[Journal Article] Vonoprazan-Based Third-Line Therapy Has a Higher Eradication Rate against Sitafloxacin-Resistant Helicobacter pylori2019
- Author(s)
  Saito Yoshimasa、Konno Kaho、Sato Moeka、Nakano Masaru、Kato Yukako、Saito Hidetsugu、Serizawa Hiroshi
- Journal Title
  
  Cancers
  
  Volume: 11 Issue: 1 Pages: 116-116
- DOI
  10.3390/cancers11010116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03592
[Journal Article] Establishment of patient-derived organoids and drug screening for biliary tract carcinoma2019
- Author(s)
  Saito Yoshimasa, Muramatsu Toshihide, Kanai Yae, Ojima Hidenori, Sukeda Aoi, Hiraoka Nobuyoshi, Arai Eri, Sugiyama Yuko, Matsuzaki Juntaro, Uchida Ryoei, Yoshikawa Nao, Furukawa Ryo, Saito Hidetsugu
- Journal Title
  
  Cell Reports
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03592
[Journal Article] Establishment of an organoid bank of biliary tract and pancreatic cancers and its application for personalized therapy and future treatment.2019
- Author(s)
  Saito Y.
- Journal Title
  
  Journal of Gastroenterology and Hepatology
  
  Volume: 34 Issue: 11 Pages: 1906-1910
- DOI
  10.1111/jgh.14773
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03592
[Journal Article] Epigenetic silencing of Lgr5 induces senescence of intestinal epithelial organoids during the process of aging2019
- Author(s)
  Uchida Ryoei、Saito Yoshimasa、Nogami Kazuki、Kajiyama Yohei、Suzuki Yukana、Kawase Yasuhiro、Nakaoka Toshiaki、Muramatsu Toshihide、Kimura Masaki、Saito Hidetsugu
- Journal Title
  
  npj Aging and Mechanisms of Disease
  
  Volume: 5 Issue: 1 Pages: 1-1
- DOI
  10.1038/s41514-019-0035-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03592
[Journal Article] CAPZA1 determines the risk of gastric carcinogenesis by inhibiting Helicobacter pylori CagA-degraded autophagy2019
- Author(s)
  Tsugawa H., Mori H., Matsuzaki J., Sato A., Saito Y., Imoto M., Suematsu M., Suzuki H.
- Journal Title
  
  Autophagy
  
  Volume: 15 Issue: 2 Pages: 242-258
- DOI
  10.1080/15548627.2018.1515530
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08550, KAKENHI-PLANNED-17H06401, KAKENHI-PROJECT-16H05291, KAKENHI-PROJECT-17H03592, KAKENHI-PROJECT-16K08349, KAKENHI-PROJECT-18H02099
[Journal Article] Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes.2019
- Author(s)
  Katsuda T, Matsuzaki J, Yamaguchi T, Yamada Y, Prieto-Vila M, Hosaka K, Takeuchi A, Saito Y, Ochiya T.
- Journal Title
  
  Elife
  
  Volume: 8
- DOI
  10.7554/elife.47313
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22818, KAKENHI-PROJECT-17H03592
[Journal Article] Genomic Profiling of Biliary Tract Cancer Cell Lines Reveals Molecular Subtypes and Actionable Drug Targets.2019
- Author(s)
  Lau DK, Mouradov D, Wasenang W, Luk IY, Scott CM, Williams DS, Yeung YH, Limpaiboon T, Iatropoulos GF, Jenkins LJ, Reehorst CM, Chionh F, Nikfarjam M, Croagh D, Dhillon AS, Weickhardt AJ, Muramatsu T, Saito Y, Tebbutt NC, Sieber OM, Mariadason JM.
- Journal Title
  
  iScience
  
  Volume: 21 Pages: 624-637
- DOI
  10.1016/j.isci.2019.10.044
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22818, KAKENHI-PROJECT-17H03592
[Journal Article] Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma.2019
- Author(s)
  Saito Y, Muramatsu T, Kanai Y, Ojima H, Sukeda A, Hiraoka N, Arai E, Sugiyama Y, Matsuzaki J, Uchida R, Yoshikawa N, Furukawa R, Saito H.
- Journal Title
  
  Cell Rep
  
  Volume: 27 Issue: 4 Pages: 1265-1276
- DOI
  10.1016/j.celrep.2019.03.088
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08720, KAKENHI-PROJECT-19K07444, KAKENHI-PROJECT-19K22818, KAKENHI-PROJECT-17H03592
[Journal Article] Bile acid metabolism regulated by the gut microbiota promotes non-alcoholic steatohepatitis-associated hepatocellular carcinoma in mice.2018
- Author(s)
  Yamada S, Takashina Y, Watanabe M, Nagamine R, Saito Y, Kamada N, Saito H.
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 11 Pages: 9925-9939
- DOI
  10.18632/oncotarget.24066
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03592, KAKENHI-PROJECT-15K09021, KAKENHI-PROJECT-16K13051
[Journal Article] Nrf2-mediated anti-oxidant effects contribute to suppression of non-alcoholic steatohepatitis-associated hepatocellular carcinoma in murine model2018
- Author(s)
  Yamada Shoji、Kimura Masaki、Saito Yoshimasa、Saito Hidetsugu
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 63 Issue: 2 Pages: 123-128
- DOI
  10.3164/jcbn.17-125
- NAID
  130007480019
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03592
[Journal Article] Induction of differentiation of intrahepatic cholangiocarcinoma cells to functional hepatocytes using an organoid culture system2018
- Author(s)
  Saito Yoshimasa、Nakaoka Toshiaki、Muramatsu Toshihide、Ojima Hidenori、Sukeda Aoi、Sugiyama Yuko、Uchida Ryoei、Furukawa Ryo、Kitahara Aya、Sato Toshiro、Kanai Yae、Saito Hidetsugu
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 2821-2821
- DOI
  10.1038/s41598-018-21121-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26115007, KAKENHI-PROJECT-17H06176, KAKENHI-PROJECT-17H03592, KAKENHI-PROJECT-15K09021, KAKENHI-PROJECT-16K13051, KAKENHI-PROJECT-16H02472
[Journal Article] Dual effects of the Nrf2 inhibitor for inhibition of hepatitis C virus and hepatic cancer cells.2018
- Author(s)
  Murakami Y, Sugiyama K, Ebinuma H, Nakamoto N, Ojiro K, Chu PS, Taniki N, Saito Y, Teratani T, Koda Y, Suzuki T, Saito K, Fukasawa M, Ikeda M, Kato N, Kanai T, Saito H.
- Journal Title
  
  BMC Cancer.
  
  Volume: 3 Issue: 1 Pages: 680-680
- DOI
  10.1186/s12885-018-4588-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08014, KAKENHI-PROJECT-16H05196, KAKENHI-PROJECT-17H03592
[Journal Article] A New Molecular Mechanism Underlying the Antitumor Effect of DNA Methylation Inhibitors via an Antiviral Immune Response.2017
- Author(s)
  Saito Y, Nakaoka T, Saito H
- Journal Title
  
  Advances in Protein Chemistry and Structural Biology
  
  Volume: 106 Pages: 227-242
- DOI
  10.1016/bs.apcsb.2016.08.005
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26290049, KAKENHI-PROJECT-16K13051
[Journal Article] Cluster microRNAs miR-194 and miR-215 suppress the tumorigenicity of intestinal tumor organoids.2017
- Author(s)
  Nakaoka T, Saito Y, Shimamoto Y, Muramatsu T, Kimura M, Kanai Y, Saito H.
- Journal Title
  
  Cancer Sci,
  
  Volume: 108 Issue: 4 Pages: 678-684
- DOI
  10.1111/cas.13165
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02472, KAKENHI-PROJECT-26290049, KAKENHI-PROJECT-15K09021, KAKENHI-PROJECT-16K13051, KAKENHI-PROJECT-17H03592
[Journal Article] Gut microbiota-mediated generation of saturated fatty acids elicits inflammation in the liver in murine high-fat diet-induced steatohepatitis.2017
- Author(s)
  Yamada S, Kamada N, Amiya T, Nakamoto N, Nakaoka T, Kimura M, Saito Y, Ejima C, Kanai T, Saito H.
- Journal Title
  
  BMC Gastroenterology
  
  Volume: 17 Issue: 1 Pages: 136-136
- DOI
  10.1186/s12876-017-0689-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03592, KAKENHI-PROJECT-15K09021, KAKENHI-PROJECT-16K13051
[Journal Article] Aberrant DNA Methylation as a Biomarker and a Therapeutic Target of Cholangiocarcinoma.2017
- Author(s)
  Nakaoka T, Saito Y, Saito H.
- Journal Title
  
  International Journal of Molecular Science
  
  Volume: 18 Issue: 6 Pages: 1111-1111
- DOI
  10.3390/ijms18061111
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03592, KAKENHI-PROJECT-15K09021, KAKENHI-PROJECT-16K13051
[Journal Article] Inhibition of DNA Methylation Suppresses Intestinal Tumor Organoids by Inducing an Anti-Viral Response.2016
- Author(s)
  Saito Y, Nakaoka T, Sakai K, Muramatsu T, Toshimitsu K, Kimura M, Kanai T, Sato T, Saito H
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 25311-25311
- DOI
  10.1038/srep25311
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26290049, KAKENHI-PROJECT-15K09021, KAKENHI-PROJECT-16K13051
[Journal Article] microRNA-mediated resistance to hypoglycemia in the HepG2 human hepatoma cell line.2016
- Author(s)
  Ueki S, Murakami Y, Yamada S, Kimura M, Saito Y, Saito H
- Journal Title
  
  BMC Cancer
  
  Volume: 16 Issue: 1 Pages: 732-732
- DOI
  10.1186/s12885-016-2762-7
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26290049, KAKENHI-PROJECT-15K09021, KAKENHI-PROJECT-16K13051
[Journal Article] Inhibition of DNA Methylation Suppresses Intestinal Tumor Organoids by Inducing an Anti-Viral Response2016
- Author(s)
  Yoshimasa Saito, Toshiaki Nakaoka, Kasumi Sakai, Toshihide Muramatsu, Kohta Toshimitsu, Masaki Kimura, Takanori Kanai, Toshiro Sato, Hidetsugu Saito
- Journal Title
  
  Scientific Reports
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26290049
[Journal Article] First-line eradication for Helicobacter pylori-positive gastritis by esomeprazole-based triple therapy is influenced by CYP2C19 genotype.2015
- Author(s)
  Saito Y, Serizawa H, Kato Y, Nakano M, Nakamura M, Saito H, Suzuki H, Kanai T.
- Journal Title
  
  World J. Gastroenterol.
  
  Volume: 21 Issue: 48 Pages: 13548-54
- DOI
  10.3748/wjg.v21.i48.13548
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26670065, KAKENHI-PROJECT-25293178, KAKENHI-PROJECT-26290049
[Journal Article] microRNA-34a as a therapeutic agent against human cancer.2015
- Author(s)
  Saito Y, Nakaoka T, Saito H.
- Journal Title
  
  J Clin Med
  
  Volume: 4 Issue: 11 Pages: 1951-1959
- DOI
  10.3390/jcm4111951
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09021, KAKENHI-PROJECT-26290049
[Journal Article] Inhibitors of enhancer of zeste homolog 2 (EZH2) activate tumor-suppressor microRNAs in human cancer cells2014
- Author(s)
  Hibino S, Saito Y, Muramatsu T, Otani A, Kasai Y, Kimura M, Saito H
- Journal Title
  
  Oncogenesis
  
  Volume: 3 Issue: 5 Pages: e104-e104
- DOI
  10.1038/oncsis.2014.17
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23680090, KAKENHI-PROJECT-24590993
[Journal Article] Acyl-CoA:cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells.2014
- Author(s)
  Tomita K, Teratani T, Suzuki T, Shimizu M, Sato H, Narimatsu K, Usui S, Furuhashi H, Kimura A, Nishiyama K, Maejima T, Okada Y, Kurihara C, Shimamura K, Ebinuma H, Saito H, Yokoyama H, Watanabe C, Komoto S, Nagao S, Sugiyama K, Aosasa S, Hatsuse K, Yamamoto J, Hibi T, Miura S, Hokari R, Kanai T.
- Journal Title
  
  Journal of Hepatology
  
  Volume: 印刷中 Issue: 1 Pages: 98-106
- DOI
  10.1016/j.jhep.2014.03.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591001, KAKENHI-PROJECT-24590993, KAKENHI-PROJECT-24790719
[Journal Article] Alterations of epigenetics and microRNA in hepatocellular carcinoma2014
- Author(s)
  Saito Y, Hibino S, Saito H
- Journal Title
  
  Hepatol Res
  
  Volume: 44(1) Issue: 1 Pages: 31-42
- DOI
  10.1111/hepr.12147
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23680090, KAKENHI-PROJECT-24590993
[Journal Article] Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus2014
- Author(s)
  Sugiyama, K. Ebinuma, H. Nakamoto, N. Sakasegawa, N. Murakami, Y. Chu, P. S. Usui, S. Ishibashi, Y. Wakayama, Y. Taniki, N. Murata, H. Saito, Y. Fukasawa, M. Saito, K. Yamagishi, Y. Wakita, T. Takaku, H. Hibi, T. Saito, H. Kanai, T.
- Journal Title
  
  PLoS ONE
  
  Volume: 9 Issue: 4 Pages: 849-854
- DOI
  10.1371/journal.pone.0094460
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23590551, KAKENHI-PROJECT-24590557, KAKENHI-PROJECT-24590993
[Journal Article] Epigenetic Alterations and MicroRNA Misexpression in Cancer and Autoimmune Diseases: a Critical Review.2014
- Author(s)
  Saito Y, Saito H, Liang G, Friedman JM
- Journal Title
  
  Clinical Reviews in Allergy & Immunology
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23680090
[Journal Article] Inhibitors of enhancer of zeste homologue 2 (EZH2) activate tumor suppressor microRNAs in human cancer cells.2014
- Author(s)
  Hibino S, Saito Y, Muramatsu T, Otani A, Kasai Y, Kimura M, Saito H
- Journal Title
  
  Oncogenesis
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23680090
[Journal Article] Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice2014
- Author(s)
  Tomita, K. Teratani, T. Suzuki, T. Shimizu, M. Sato, H. Narimatsu, K. Okada, Y. Kurihara, C. Irie, R. Yokoyama, H. Shimamura, K. Usui, S. Ebinuma, H. Saito, H. Watanabe, C. Komoto, S. Kawaguchi, A. Nagao, S. Sugiyama, K. Hokari, R. Kanai, T. Miura, S. Hibi, T.
- Journal Title
  
  Hepatology
  
  Volume: 59 Issue: 1 Pages: 154-169
- DOI
  10.1002/hep.26604
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590551, KAKENHI-PROJECT-23591001, KAKENHI-PROJECT-24249046, KAKENHI-PROJECT-24390190, KAKENHI-PROJECT-24590993, KAKENHI-PROJECT-24790719
[Journal Article] Silencing of microRNA-122 is an early event during hepatocarcinogenesis from non-alcoholic steatohepatitis.2014
- Author(s)
  Takaki Y, Saito Y, Takasugi A, Toshimitsu K, Yamada S, Muramatsu T, Kimura M, Sugiyama K, Suzuki H, Arai E, Ojima H, Kanai Y, Saito H.
- Journal Title
  
  Cancer Sci.
  
  Volume: 105 Issue: 10 Pages: 1254-1260
- DOI
  10.1111/cas.12498
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590993, KAKENHI-PROJECT-25460487, KAKENHI-PROJECT-25461705, KAKENHI-PROJECT-26290049, KAKENHI-PROJECT-221S0001
[Journal Article] Alterations of epigenetics and microRNAs in hepatocellular carcinoma.2014
- Author(s)
  Saito Y, Hibino S, Saito H
- Journal Title
  
  Hepatology Research
  
  Volume: 44 Pages: 31-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23680090
[Journal Article] Epigenetic Alterations and MicroRNA Misexpression in Cancer and Autoimmune Diseases : a Critical Review2013
- Author(s)
  Saito Y, Saito H, Liang G, Friedman JM
- Journal Title
  
  Clin Rev Allergy Immunol
  
  Volume: 47 Issue: 2 Pages: 128-135
- DOI
  10.1007/s12016-013-8401-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23680090, KAKENHI-PROJECT-24590993
[Journal Article] Suppressive Effect of the Histone Deacetylase Inhibitor, Suberoylanilide Hydroxamic Acid (SAHA), on Hepatitis C Virus Replication via Epigenetic Changes in Host Cells2013
- Author(s)
  Sato, A., Saito, Y., Sugiyama, K., Sakasegawa, N., Muramatsu, T., Fukuda, S., Yoneya, M., Kimura, M., Ebinuma, H., Hibi, T., Saito, H
- Journal Title
  
  J Cell Biochem
  
  Volume: 印刷中 Issue: 9 Pages: 1987-1996
- DOI
  10.1002/jcb.24541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590551, KAKENHI-PROJECT-23680090, KAKENHI-PROJECT-24590993, KAKENHI-PROJECT-25293110
[Journal Article] The tumor suppressor microRNA -29c is downregulated and restored by celecoxib in human gastric cancer cells2013
- Author(s)
  Saito Y, Suzuki H, Imaeda H, Matsuzaki J, et al.
- Journal Title
  
  International Journal of Cancer
  
  Volume: 132 Issue: 8 Pages: 1751-1760
- DOI
  10.1002/ijc.27862
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J06306, KAKENHI-PROJECT-22300169, KAKENHI-PROJECT-23390096, KAKENHI-PROJECT-23680090, KAKENHI-PROJECT-24659103, KAKENHI-PROJECT-25460173
[Journal Article] Bile Acids Increase Levels of microRNAs 221 and 222, Leading to Degradation of CDX2 During Esophageal Carcinogenesis2013
- Author(s)
  J. Matsuzaki, H. Suzuki, H. Tsugawa, M. Watanabe, S. Hossain, T. Akaike, T. Hibi, et. al.
- Journal Title
  
  Gastroenterology
  
  Volume: (In Press) Issue: 6 Pages: 1300-1311
- DOI
  10.1053/j.gastro.2013.08.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11F01350, KAKENHI-PROJECT-23220014, KAKENHI-PROJECT-23580139, KAKENHI-PROJECT-23590482, KAKENHI-PROJECT-23680090, KAKENHI-PROJECT-24659103, KAKENHI-PROJECT-25293178, KAKENHI-PROJECT-25460173, KAKENHI-PROJECT-25460487
[Journal Article] Overexpression of miR-142-5p and miR-155 in Gastric Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma Resistant to Helicobacter pylori Eradication2012
- Author(s)
  Saito y, Suzuki H, Tsugawa H, Imaeda H, Matsuzaki J, et al.
- Journal Title
  
  PLoS One
  
  Volume: 7 Issue: 11 Pages: e47396-e47396
- DOI
  10.1371/journal.pone.0047396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J06306, KAKENHI-PROJECT-22300169, KAKENHI-PROJECT-23680090, KAKENHI-PROJECT-24659103
[Journal Article] Overexpression of miR-142-5p and miR-155 in gastric mucosa-associated lymphoid tissue (MALT) lymphoma resistant to Helicobacter pylori eradication2012
- Author(s)
  Saito Y, Suzuki H, Tsugawa H, Imaeda H, Matsuzaki J, Hirata K, Hosoe N, Nakamura M, Mukai M, Saito H, Hibi T
- Journal Title
  
  PLoS One
  
  Volume: 7(11) Issue: 7
- DOI
  10.1371/annotation/53d1898f-d0ae-4e5c-a585-c084a5c881bf
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23680090
[Journal Article] Role of CTCF in the regulation of microRNA expression2012
- Author(s)
  Saito Y, Saito H
- Journal Title
  
  Front Genet
  
  Volume: 3 Pages: 186-186
- DOI
  10.3389/fgene.2012.00186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23680090, KAKENHI-PROJECT-24590993
[Journal Article] Development of a novel microRNA promoter microarray for ChIP-on chip assay to identify epigenetically regulated microRNAs2012
- Author(s)
  Saito Y, Suzuki H, Taya T, Nishizawa M, Tsugawa H, Matsuzaki J, et al.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 426 Issue: 1 Pages: 33-37
- DOI
  10.1016/j.bbrc.2012.08.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J06306, KAKENHI-PROJECT-22300169, KAKENHI-PROJECT-23680090, KAKENHI-PROJECT-24659103
[Journal Article] MicroRNAs in cancers and neurodegenerative disorders2012
- Author(s)
  Saito Y, Saito H
- Journal Title
  
  Front Genet
  
  Volume: 3 Pages: 194-194
- DOI
  10.3389/fgene.2012.00194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23680090, KAKENHI-PROJECT-24590993
[Journal Article] Efficacy of sitafloxacin-based rescue therapy for Helicobacter pylori after failure of first- and second-line therapies2011
- Author(s)
  Matsuzaki J, Suzuki H, Nishizawa T, Hirata K, Tsugawa H, Saito Y, Okada S, Fukuhara S, Hibi T
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 56 Pages: 1643-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23680090
[Journal Article] Dysfunctional gastric emptying with downregulation of muscle-specific microRNAs in Helicobacter pylori-infected mice.2011
- Author(s)
  Saito Y, Suzuki H, Tsugawa H, Suzuki S, Matsuzaki J, Hirata K, Hibi T.
- Journal Title
  
  Gastroenterology. 140(1)
  
  Pages: 189-198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790327
[Journal Article] Dysfunctional gastric emptying with down-regulation of muscle-specific MicroRNAs in Helicobacter pylori-infected mice2011
- Author(s)
  Saito, Y., Suzuki, H, et al.
- Journal Title
  
  Gastroenterology
  
  Volume: 140(1) Pages: 189-198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300169
[Journal Article] Etiological difference between ultrashort-segment Barrett's esophagus and short-segment Barrett's esophagus in Japan2011
- Author(s)
  Matsuzaki, J., Suzuki, H., Saito, Y., et al.
- Journal Title
  
  J. Gastroenterol.
  
  Volume: 46(3) Issue: 3 Pages: 332-8
- DOI
  10.1007/s00535-010-0353-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300169
[Journal Article] MicroRNAs in hepatobiliary and pancreatic cancers2011
- Author(s)
  Saito Y, Suzuki H, Matsuura M, Sato A, Kasai Y, Yamada K, Saito H, Hibi T
- Journal Title
  
  Frontiers in Genetics
  
  Volume: 2(66) Pages: 1-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23680090
[Journal Article] MicroRNAs in hepatobiliary and pancreatic cancers.2011
- Author(s)
  Saito, Y., Suzuki, H., et al.
- Journal Title
  
  Front. Gene.
  
  Volume: 2 Pages: 66-66
- DOI
  10.3389/fgene.2011.00066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300169
[Journal Article] Effect of lansoprazole versus roxatidine on prevention of bleeding and promotion of ulcer healing after endoscopic submucosal dissection for superficial gastric neoplasia2011
- Author(s)
  Imaeda H, Hosoe N, Suzuki H, Saito Y, Ida Y, Nakamura R, Iwao Y, Ogata H, Hibi T
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 46 Pages: 1267-72
- NAID
  10030294788
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23680090
[Journal Article] Two amino acids mutation of Ferric uptake regulator (Fur) determines Helicobacter pylori resistance to metronidazole.2011
- Author(s)
  Tsugawa, H., Suzuki, H., Saito, Y., et al.
- Journal Title
  
  Antioxid. Redox Signal
  
  Volume: 14(1) Issue: 1 Pages: 15-23
- DOI
  10.1089/ars.2010.3146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300169
[Journal Article] Dysfunctional gastric emptying with downregulation of muscle-specific microRNAs in Helicobacter pylori -infected mice.2011
- Author(s)
  Saito, Y., Suzuki, H., et al.
- Journal Title
  
  Gastroenterology
  
  Volume: 140(1) Issue: 1 Pages: 189-198
- DOI
  10.1053/j.gastro.2010.08.044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300169
[Journal Article] Dysfunctional gastric emptying with downregulation of muscle-specific microRNAs in Helicobacter pylori-infected mice.2011
- Author(s)
  Yoshimasa Saito, 他
- Journal Title
  
  Gastroenterology
  
  Volume: 140(1) Pages: 189-198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790327
[Journal Article] Effect of lansoprazole versus roxatidine on prevention of bleeding and ulcer healing after endoscopic submucosal dissection for superficial gastric neoplasia2011
- Author(s)
  Imaeda, H., Suzuki, H., Saito, Y., et al.
- Journal Title
  
  J. Gastroenterol.
  
  Volume: 46(11) Issue: 11 Pages: 1267-72
- DOI
  10.1007/s00535-011-0447-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300169
[Journal Article] DNMT1 and DNMT3b silencing sensitizes human hepatoma cells to TRAIL-mediated apoptosis via up-regulation of TRAIL-R2/DR5 and caspase-8.2010
- Author(s)
  Kurita S, Higuchi H, Saito Y, Nakamoto N, Takaishi H, Tada S, Saito H, Gores G, Hibi T.
- Journal Title
  
  Cancer Sci. 101(6)
  
  Pages: 1431-1439
- NAID
  10026593495
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790327
[Journal Article] DNMT1 and DNMT3b silencing sensitizes human hepatoma cells to TRAIL-mediated apoptosis via up-regulation of TRAIL-R2/DRS and caspase-82010
- Author(s)
  Satoshi Kurita, Yoshimasa Saito, 他
- Journal Title
  
  Cancer Science
  
  Volume: 101(6) Pages: 1431-1439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790327
[Journal Article] Contribution of efflux pumps to clarithromycin resistance in Helicobacter pylori2010
- Author(s)
  Hirata, K., Suzuki, H., Saito, Y., et al.
- Journal Title
  
  J. Gastroenterol. Hepatol.
  
  Volume: 25(s1) Issue: s1
- DOI
  10.1111/j.1440-1746.2009.06220.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300169
[Journal Article] Gallstones increase the prevalence of Barrett's esophagus.2010
- Author(s)
  Matsuzaki, J., Suzuki, H., Saito, Y., et al.
- Journal Title
  
  J. Gastroenterol.
  
  Volume: 45(2) Issue: 2 Pages: 171-8
- DOI
  10.1007/s00535-009-0153-4
- NAID
  10027214436
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300169
[Journal Article] The role of microRNAs in gastrointestinal cancers.2009
- Author(s)
  Yoshimasa Saito, 他
- Journal Title
  
  Journal of Gastroenterology 44 Suppl 19
  
  Pages: 18-22
- NAID
  10025176863
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790327
[Journal Article] Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced microRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells2009
- Author(s)
  Saito Y, Suzuki H, Tsugawa H, Nakagawa I, Matsuzaki J, Kanai Y, Hibi T
- Journal Title
  
  Oncogene (in press)
- Data Source
  KAKENHI-PROJECT-19599024
[Journal Article] The role of microRNAs in gastrointestinal cancers.2009
- Author(s)
  Yoshimasa Saito, 他
- Journal Title
  
  Journal of Gastroenterology 44 Suppl19
  
  Pages: 18-22
- NAID
  10025176863
- Data Source
  KAKENHI-PROJECT-19599024
[Journal Article] Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced miRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells2009
- Author(s)
  Yoshimasa Saito, 他
- Journal Title
  
  Oncogene (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19599024
[Journal Article] Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced microRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells.2009
- Author(s)
  Saito Y, Suzuki H, Tsugawa H, Nakagawa I, Matsuzaki J, Kanai Y, Hibi T.
- Journal Title
  
  Oncogene. 28(30)
  
  Pages: 2738-2744
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790327
[Journal Article] The role of microRNAs in gastrointestinal cancers.2009
- Author(s)
  Saito Y, Suzuki H, Hibi T.
- Journal Title
  
  J Gastroenterol. 44 Suppl 19
  
  Pages: 18-22
- NAID
  10025176863
- Data Source
  KAKENHI-PROJECT-21790327
[Journal Article] The role of microRNAs in gastrointestinal cancers2009
- Author(s)
  Saito Y, Suzuki H, Hibi T
- Journal Title
  
  J Gastroenterol 19
  
  Pages: 18-22
- NAID
  10025176863
- Data Source
  KAKENHI-PROJECT-19599024
[Journal Article] Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells2009
- Author(s)
  Saito Y, Friedman JM, Chihara Y, Egger G, Chuang JC, Liang G
- Journal Title
  
  Biochem Biophys Res Commun 379(3)
  
  Pages: 726-731
- Data Source
  KAKENHI-PROJECT-19599024
[Journal Article] Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced miRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells2009
- Author(s)
  Yoshimasa Saito, 他
- Journal Title
  
  Oncogene 28(30)
  
  Pages: 2738-2744
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790327
[Patent] 癌治療用医薬組成物2018
- Inventor(s)
  齋藤義正、齋藤英胤、杉山優子、村松俊英
- Industrial Property Rights Holder
  学校法人慶應義塾
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17H03592
[Patent] 胆道癌オルガノイド又は膵臓癌オルガノイドの培養用培地2018
- Inventor(s)
  齋藤義正、金井弥栄、村松俊英
- Industrial Property Rights Holder
  齋藤義正、金井弥栄、村松俊英
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17H03592
[Patent] がん幹細胞集団の調製方法、異種移植片の調製方法、スクリーニング方法、ｍｉＲ－３４ａの発現量を低下させる方法及びがん幹細胞増殖抑制剤2015
- Inventor(s)
  齋藤義正　他4名
- Industrial Property Rights Holder
  齋藤義正　他4名
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-142164
- Filing Date
  2015-07-16
- Data Source
  KAKENHI-PROJECT-26290049
[Patent] がん幹細胞集団の調製方法2014
- Inventor(s)
  齋藤義正、齋藤英胤、佐藤俊朗、尾島英知、金井弥栄、村松俊英
- Industrial Property Rights Holder
  慶應義塾
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-146144
- Filing Date
  2014-07-16
- Data Source
  KAKENHI-PROJECT-26290049
[Presentation] Impact of acquiring cancer driver gene mutations for EV-miRNA profiles derived from pancreatic epithelial cells.2023
- Author(s)
  Matsuzaki J, Oikawa C, Katsuda T, Yamaguchi T, Shibagaki R, Yoshimizu K, Ochiya T, Saito Y
- Organizer
  International Society for Extracellular Vesicles (ISEV) 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24188
[Presentation] 膵管上皮細胞におけるドライバー遺伝子変異とマウス生着能・生存率の関連性2023
- Author(s)
  柴垣里奈, 松崎潤太郎, 落谷孝広, 齋藤義正
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24188
[Presentation] 膵がんドライバー遺伝子変異誘導による形質変化の追跡2022
- Author(s)
  及川千尋, 松崎潤太郎, 落谷孝広、齋藤義正
- Organizer
  第81回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24188
[Presentation] 膵発がん過程における膵上皮由来EVの形質変化の追跡2022
- Author(s)
  及川千尋, 松崎潤太郎, 落谷孝広, 齋藤義正
- Organizer
  第9回日本細胞外小胞学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24188
[Presentation] 誘導性CRISPR/dCas9を用いたC19MCの肝内胆管癌オルガノイドの分化における役割の解明2022
- Author(s)
  葉子祥、松崎潤太郎、及川千尋、金井弥栄、齋藤義正
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03533
[Presentation] 膵がんドライバー遺伝子変異誘導による形質変化の追跡2022
- Author(s)
  及川千尋、松崎潤太郎、落谷孝広、齋藤義正
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03533
[Presentation] スタチン製剤の胆管がん抑制作用に関する検討2021
- Author(s)
  富永皓斗、松﨑潤太郎、齋藤義正
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03533
[Presentation] 難治性がんオルガノイドを用いた創薬研究2021
- Author(s)
  齋藤義正
- Organizer
  第20回日本再生医療学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03533
[Presentation] セリバスタチンのヒト肝内胆管がん(IHCC)抑制作用に関する検討2021
- Author(s)
  富永皓斗、松﨑潤太郎、齋藤義正
- Organizer
  日本消化器関連学会週間(JDDW2021)
- Data Source
  KAKENHI-PROJECT-20H03533
[Presentation] 老齢腸管上皮organoidに対するNAD+ 前駆体の抗老化効果と分子メカニズムの解明2020
- Author(s)
  野上和幹、齋藤義正、山西健太、木村真規
- Organizer
  第20回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-19K22818
[Presentation] マイクロ流体デバイスでの共培養モデルにおいて、肝星細胞は胆管癌オルガノイドの浸潤を抑制する2020
- Author(s)
  須田雄大、齋藤義正
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03533
[Presentation] オルガノイド培養による難治性がんの前臨床モデルの確立と創薬研究への応用2019
- Author(s)
  齋藤義正，村松俊英，齋藤英胤
- Organizer
  第105回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-17H03592
[Presentation] Organoid培養法により樹立した腸管上皮幹細胞に対するNMN (Nicotinamide mononucleotide) による抗老化効果の検討2019
- Author(s)
  野上和幹、内田諒英、梶山洋平、鈴木裕佳水、齋藤義正、木村真規、齋藤英胤
- Organizer
  第19回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-19K22818
[Presentation] Organoid培養法により樹立した腸管上皮幹細胞に対するNMN (Nicotinamide mononucleotide) による抗老化効果の検討2019
- Author(s)
  野上和幹、内田諒英、梶山洋平、鈴木裕佳水、齋藤義正、木村真規、齋藤英胤
- Organizer
  第19回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-17H03592
[Presentation] A new 3D co-culture model of intrahepatic cholangiocarcinoma organoids and hepatic stellate cells in a microfluidic device.2019
- Author(s)
  須田雄大、齋藤義正、齋藤英胤
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H03592
[Presentation] オルガノイド培養による難治性がんの前臨床モデルの構築とその創薬への応用2019
- Author(s)
  齋藤義正
- Organizer
  細胞アッセイ研究会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17H03592
[Presentation] 肝内胆管がんオルガノイドの樹立と分化誘導による肝細胞性の獲得2018
- Author(s)
  齋藤義正、中岡俊哉、村松俊英、杉山優子、木村真規、齋藤英胤
- Organizer
  第104回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-17H03592
[Presentation] Establishment and long-term in vitro culture of organoids derived from human biliary tract carcinomas2018
- Author(s)
  Saito Yoshimasa, Muramatsu Toshihide, Sugiyama Yuko, Uchida Ryoei, Furukawa Ryo, Yoshikawa Nao, Kimura Masaki, Saito Hidetsugu
- Organizer
  Annual Meeting of American Association for Cancer Research (AACR) 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03592
[Presentation] 胆道系悪性腫瘍由来オルガノイドの長期培養と創薬研究への応用2018
- Author(s)
  齋藤義正、齋藤英胤
- Organizer
  第54回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-17H03592
[Presentation] Establishment of an organoid bank of biliary tract and pancreatic cancers and its application for personalized therapy2018
- Author(s)
  Saito Yoshimasa
- Organizer
  Asian Pacific Digestive Week 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03592
[Presentation] Establishment of preclinical models for refractory cancers by organoid culture and its application for drug discovery2018
- Author(s)
  Saito Yoshimasa
- Organizer
  2018 International Meeting on 22nd MDO and 33rd JSSX
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03592
[Presentation] オルガノイド培養技術を用いたがん研究2017
- Author(s)
  齋藤義正、中岡哉彰、村松俊英、木村真規、齋藤英胤
- Organizer
  第17回日本抗加齢医学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03592
[Presentation] Intrahepatic cholangiocarcinoma cells can be converted into functional hepatocytes by inhibition of Wnt signaling pathway.2017
- Author(s)
  Saito Y, Nakaoka T, Muramatsu T, Kimura M, Saito H.
- Organizer
  American Association for Cancer Research (AACR) Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K13051
[Presentation] DNAメチル化阻害による抗ウイルス免疫応答の活性化を介した胆道がんオルガノイドの増殖抑制2017
- Author(s)
  古川遼、齋藤義正、齋藤英胤
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H03592
[Presentation] Intrahepatic cholangiocarcinoma cells can be converted into functional hepatocytes by inhibition of Wnt signaling pathway.2017
- Author(s)
  Saito Y, Nakaoka T, Muramatsu T, Kimura M, Saito H.
- Organizer
  American Association for Cancer Research (AACR) Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03592
[Presentation] Intrahepatic cholangiocarcinoma cells can be converted into functional hepatocytes by inhibition of Wnt signaling pathway.2017
- Author(s)
  Saito Y, Nakaoka T, Muramatsu T, Kimura M, Saito H
- Organizer
  American Association for Cancer Research (AACR) Annual Meeting 2017
- Place of Presentation
  Washington DC, USA
- Year and Date
  2017-04-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290049
[Presentation] オルガノイド培養技術による難治性がんのin vitroモデルの構築と創薬研究への応用2017
- Author(s)
  齋藤義正
- Organizer
  第77回分析化学討論会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03592
[Presentation] 胆管がんオルガノイドにおける糖欠乏下での幹細胞性の増強2017
- Author(s)
  吉川直、齋藤義正、齋藤英胤
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H03592
[Presentation] 腸管上皮オルガノイドにおけるエピゲノム変化に着目したステムセルエイジングの解明2017
- Author(s)
  齋藤義正、内田諒英、村松俊英、木村真規、齋藤英胤
- Organizer
  第17回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-16K13051
[Presentation] オルガノイド培養技術による難治性がんのin vitroモデルの構築と創薬研究への応用2017
- Author(s)
  齋藤義正
- Organizer
  第77回分析化学討論会
- Invited
- Data Source
  KAKENHI-PROJECT-16K13051
[Presentation] 胆管がんオルガノイドにおける糖欠乏下での幹細胞性の増強2017
- Author(s)
  吉川直、齋藤義正、齋藤英胤
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K13051
[Presentation] オルガノイド培養技術を用いたがんエピゲノム研究の進展開2016
- Author(s)
  齋藤義正, 中岡哉彰, 村松俊英, 木村真規, 齋藤英胤
- Organizer
  第53回日本臨床分子医学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-04-16
- Invited
- Data Source
  KAKENHI-PROJECT-26290049
[Presentation] Inhibition of DNA Methylation Suppresses Intestinal Tumor Organoids by Inducing an Anti-Viral Response.2016
- Author(s)
  Saito Y, Sakai K, Muramatsu T, Nakaoka T, Kimura M, Saito H
- Organizer
  American Association for Cancer Research (AACR) Annual Meeting 2016
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-04-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290049
[Presentation] Inhibition of DNA Methylation Suppresses Intestinal Tumor Organoids by Inducing an Anti-Viral Response.2016
- Author(s)
  Saito Y, Sakai K, Muramatsu T, Nakaoka T, Kimura M, Saito H.
- Organizer
  American Association for Cancer Research (AACR) Annual Meeting 2016
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-04-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K13051
[Presentation] Inhibition of DNA Methylation Suppresses Intestinal Tumor Organoids by Inducing an Anti-Viral Response2016
- Author(s)
  Yoshimasa Saito, Kasumi Sakai, Kohta Toshimitsu, Toshihide Muramatsu, Toshiaki Nakaoka, Masaki Kimura, Hidetsugu Saito
- Organizer
  Annual Meeting of American Association for Cancer Research (AACR)
- Place of Presentation
  ニューオーリンズ（アメリカ合衆国）
- Year and Date
  2016-04-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290049
[Presentation] 腸管腫瘍オルガノイドにおける miR-194 および miR-215 を含むマイクロRNAクラスターの役割2015
- Author(s)
  中岡哉, 齋藤義正, 島本百合子, 村松俊英, 木村真規, 齋藤英胤.
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26290049
[Presentation] MiR-1246 and miR-302 are novel targets of epigenetic therapy with DZNep and SAHA in human cancer cells2013
- Author(s)
  Hibino S, Saito Y, Muramatsu T, Otani A, Kasai Y, Kimura M, Saito H
- Organizer
  Digestive Disease Week 2013
- Place of Presentation
  Orlando, FL.
- Data Source
  KAKENHI-PROJECT-23680090
[Presentation] NASH-肝発がんモデルにおけるマイクロRNA発現の網羅的解析と新規治療への応用2013
- Author(s)
  高木陽子, 齋藤義正, 高杉梓, 甲浩子, 植木里美, 山田翔士, 村松俊英, 木村真規, 齋藤英胤
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23680090
[Presentation] メタボローム・トランスクリプトーム統合的解析によるC型肝炎肝脂肪蓄積の機構解明．2013
- Author(s)
  杉山和夫、齋藤英胤、日比紀文．
- Organizer
  第17回日本肝臓学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590993
[Presentation] がん細胞に対するDZNepおよびSAHAの投与によるマイクロRNA発現変化の網羅的検討2013
- Author(s)
  日比野沙奈,齋藤義正,村松俊英,大谷亜希,笠井雄祐,植木里美,山田翔士,木村真規,齋藤英胤
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23680090
[Presentation] ヒストン修飾制御薬によるマイクロRNAを介した抗がん作用の検討．2013
- Author(s)
  日比野沙奈、齋藤義正、村松俊英、大谷亜希、笠井雄佑、植木里美、山田翔士、木村真規、齋藤英胤．
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24590993
[Presentation] HCV感染細胞における転写因子Nrf2によって制御される遺伝子群の発現解析．2013
- Author(s)
  酒瀬川典子、杉山和夫、海老沼浩利、中本伸宏、村上優子、齋藤英胤、金井隆典．
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24590993
[Presentation] Epigenetic作用薬を用いたC型肝炎ウイルスの制御：ヒストン脱アセチル化阻害薬の有用性．2013
- Author(s)
  齋藤英胤、齋藤義正、杉山和夫．
- Organizer
  第49回日本肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590993
[Presentation] The tumor suppressor microRNA-122 is suppressed in liver cancer cells and can be reactivated by DNA methylation inhibitors.2013
- Author(s)
  Matsuura M, Saito Y, Doke Y, Yoshida T, Genka A, Muramatsu T, Kimura M, Arai E, Kanai Y, Saito H
- Organizer
  Digestive Disease Week 2013
- Place of Presentation
  Orlando, FL
- Data Source
  KAKENHI-PROJECT-23680090
[Presentation] ヒストン修飾制御薬によるマイクロRNAを介した抗がん作用の検討2013
- Author(s)
  日比野沙奈,齋藤義正,村松俊英,大谷亜希,笠井雄祐,植木里美,山田翔士,木村真規,齋藤英胤
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23680090
[Presentation] MiR-1246 and miR-302 are novel targets of epigenetic therapy with DZNep and SAHA in human cancer cells.2013
- Author(s)
  Hibino S, Saito Y, Muramatsu T, Otani A, Kasai Y, Kimura M, Saito H
- Organizer
  Digestive Disease Week 2013
- Place of Presentation
  Orlando, FL
- Data Source
  KAKENHI-PROJECT-23680090
[Presentation] Nrf2/sMaf転写因子複合体はHCVによる肝細胞脂肪蓄積に関与する．2013
- Author(s)
  杉山和夫、海老沼浩利、酒瀬川典子、齋藤義正、金井隆典、日比紀文、齋藤英胤．
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24590993
[Presentation] NASH-肝発がんモデルにおけるマイクロRNA発現の網羅的解析と新規治療への応用2013
- Author(s)
  齋藤義正、高杉梓、齋藤英胤
- Organizer
  第55回日本消化器病学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23680090
[Presentation] MiR-1246 and miR-302 are novel target of epigenetic therapy with DZNep and SAHA in human cancer cells.2013
- Author(s)
  Hibino S, Saito Y, Muramatsu T, Otani A, Kasai Y, Kimura M, Saito H.
- Organizer
  Digestive Disease Week 2013
- Place of Presentation
  Orlando, USA
- Data Source
  KAKENHI-PROJECT-24590993
[Presentation] The tumor suppressor microRNA-122 is suppressed in liver cancer cells and can be reactivated by DNA methylation inhibitors2013
- Author(s)
  Matsuura M, Saito Y, Doke Y, Yoshida T, Genka A, Muramatsu T, Kimura M, Arai E, Kanai Y, Saito H
- Organizer
  Digestive Disease Week 2013
- Place of Presentation
  Orlando, FL.
- Data Source
  KAKENHI-PROJECT-23680090
[Presentation] Dysfunctional gastric emptying with downregulation of muscle-specific microRNAs in Helicobacter pylori -infected mice.2012
- Author(s)
  Saito, Y., Suzuki, H., et al.
- Organizer
  The 2nd Asian Pacific Topic Conference, Asian Pacific Helicobacter pylori Meeting 2012
- Place of Presentation
  Kuala Lumpur, Malaysia
- Data Source
  KAKENHI-PROJECT-22300169
[Presentation] Dysfunctional gastric emptying with downregulation of muscle-specific microRNAs in Helicobacter pylori-infected mice2012
- Author(s)
  Saito Y, Suzuki H, Tsugawa H, Suzuki S, Matsuzaki J, Hirata K, Saito H, Hibi T
- Organizer
  The 2nd Asian Pacific Topic Conference, Asian Pacific Helicobacter Pylori Meeting 2012
- Place of Presentation
  Kuala Lumpur, Malaysia
- Year and Date
  2012-01-14
- Data Source
  KAKENHI-PROJECT-23680090
[Presentation] Usefulness of long-term (over 2 years) cultured cell clone persistently and productively infected with chimeric HCV.2012
- Author(s)
  Sugiyama K, Saito H, Ebinuma H, Sakasegawa N, Murakami Y, Nakamoto N, Usui S, Ishibashi Y, Chu P-S, Wakayama Y, Saito Y, Kanai T, Hibi T.
- Organizer
  63th Annual Meeting of American Association for the Study of Liver Diseases (AASLD)
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-24590993
[Presentation] ヒストン脱アセチル化酵素阻害薬suberoylanilide hydroxamic acid (SAHA)によるC型肝炎ウイルス（HCV）の増殖抑制効果．2012
- Author(s)
  佐藤郁美、齋藤義正、永見早耶花、酒瀬川典子、福田真也、木村真規、杉山和夫、海老沼浩利、齋藤英胤．
- Organizer
  第48回日本肝臓学会総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-24590993
[Presentation] がんに対するエピジェネティック治療によるマイクロRNA発現変化の網羅的解析2012
- Author(s)
  齋藤義正,村松俊英,木村真規,齋藤英胤
- Organizer
  日本分子腫瘍マーカー研究会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23680090
[Presentation] C型肝炎ウイルス持続感染培養肝細胞の樹立と応用．2012
- Author(s)
  杉山和夫、齋藤英胤、日比紀文．
- Organizer
  第39回日本肝臓学会東部会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590993
[Presentation] Enhanced Expression of MicroRNA-142-5p and MicroRNA-155 and Suppressed Expression of Tp53inp1 Would Be Novel Molecular Biomarkers for Gastric Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma, Resistant to H. pylori Eradication.2011
- Author(s)
  Suzuki, H., Saito, Y., et al.
- Organizer
  AGA Research Forum DDW2011
- Place of Presentation
  Chicago, USA
- Year and Date
  2011-05-07
- Data Source
  KAKENHI-PROJECT-22300169
[Presentation] 発がん過程におけるエピジェネティクスとマィクロRNAの異常2011
- Author(s)
  齋藤義正
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋(日本癌学会奨励賞受賞講演)
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-23680090
[Presentation] The selective cyclooxygenase-2 inhibitor celecoxib activates the tumor suppressor microRNA-29c in human gastric cancer.2011
- Author(s)
  Saito, Y., Suzuki, H, et al.
- Organizer
  第7回日本消化管学会, 4^<th> IGICS
- Place of Presentation
  国立京都国際会館(京都市)
- Year and Date
  2011-02-19
- Data Source
  KAKENHI-PROJECT-22300169
[Presentation] Proliferation of cdx2-expressing human esophageal cells is enhanced by bile acid with upregulation.2011
- Author(s)
  Matsuzaki, J., Suzuki, H., Saito, Y., and Akaike, T., et al.
- Organizer
  UEGW2011
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2011-10-25
- Data Source
  KAKENHI-PROJECT-22300169
[Presentation] Activation of the tumor suppressor microRNA-29cby the selective cyclooxygenase-2 inhibitor, celecoxib in human gastric cancer.2011
- Author(s)
  Suzuki, H., Saito, Y., Kanai, Y., et al
- Organizer
  AGA Research Forum DDW2011
- Place of Presentation
  Chicago, USA
- Year and Date
  2011-05-09
- Data Source
  KAKENHI-PROJECT-22300169
[Presentation] Chronic infection with Helicobacter pylori induces downregulation of muscle-specific microRNAs and smooth muscle hypertrophy of the mouse stomach.2010
- Author(s)
  Saito Y, Suzuki H, Tsugawa H, Suzuki S, Matsuzaki J, Hirata K, Hibi T.
- Organizer
  Digestive Disease Week Oral presentation
- Place of Presentation
  New Orleans, USA
- Year and Date
  2010-05-02
- Data Source
  KAKENHI-PROJECT-21790327
[Presentation] Overexpression of miR-142-5p and miR-155 and suppression of tumor protein 53-induced nuclear protein 1 in gastric mucosa-associated lymphoid tissue lymphoma.2010
- Author(s)
  Saito Y, Suzuki H, Tsugawa H, Imaeda H, Matsuzaki J, Hirata K, Hosoe N, Nakamura M, Hibi T.
- Organizer
  Digestive Disease Week Oral presentation
- Place of Presentation
  New Orleans, USA
- Year and Date
  2010-05-02
- Data Source
  KAKENHI-PROJECT-21790327
[Presentation] The role of the Ferric uptake regulator (Fur) in Helicobacter pylori resistance to metronidazole.2010
- Author(s)
  Tsugawa, H., Suzuki, H., Saito, Y., et al.
- Organizer
  AGA Research Forum DDW2010
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-22300169
[Presentation] マイクロRNAを介した胃癌に対するエピジェネティック治療2010
- Author(s)
  斎藤義正, 鈴木秀和, ら
- Organizer
  第96回日本消化器病学会総会
- Place of Presentation
  新潟市
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-22300169
[Presentation] Overexpression of miR-142-5pand miR-155and suppression of tumor protein 53-induced nuclear protein 1 in gastric mucosa-associated lymphoid tissue lymphoma.2010
- Author(s)
  Saito, Y., Suzuki, H., et al.
- Organizer
  AGA Research Forum DDW2010
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-22300169
[Presentation] Overexpression of miR-142-5p and miR-155 and suppression of tumor protein 53-induced nuclear protein 1 in gastric mucosa-associated lymphoid tissue lymphoma.2010
- Author(s)
  Saito, Y., Suzuki, H., et al.
- Organizer
  Digestive Disease Week 2010
- Place of Presentation
  New Orleans, USA
- Year and Date
  2010-05-02
- Data Source
  KAKENHI-PROJECT-22300169
[Presentation] Nitric oxide involvement in gastric disorders.2010
- Author(s)
  Suzuki, H. (invited), Saito, Y., et al
- Organizer
  Symposium SP-04 "Nitrosative stress in the gastrointestinal tract", The 6thInternational Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2010-06-15
- Data Source
  KAKENHI-PROJECT-22300169
[Presentation] Downregulation of the tumor suppressor microRNA-29c plays a critical role in the progression of human gastric cancer.2010
- Author(s)
  Saito, Y., Suzuki, H, et al.
- Organizer
  Digestive Disease Week 2010
- Place of Presentation
  New Orleans, USA
- Year and Date
  2010-05-05
- Data Source
  KAKENHI-PROJECT-22300169
[Presentation] Caudal-related homeobox 2 (Cdx2) suppresses stratification of esophageal squamous epithelial cells by down-regulating microRNA-221/2222010
- Author(s)
  Matsuzaki, J., Suzuki, H., Saito, Y., et al.
- Organizer
  DDW2010
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-22300169
[Presentation] Downregulation of the tumor suppressor microRNA-29c plays a critical role in the progression of human gastric cancer.2010
- Author(s)
  Yoshimasa Saito, 他
- Organizer
  アメリカ消化器病学会(DDW2010)
- Place of Presentation
  米国ルイジアナ州ニューオリンズ
- Year and Date
  2010-05-05
- Data Source
  KAKENHI-PROJECT-21790327
[Presentation] Induction of H. pylori resistance to metronidazole through enhanced expression of a bacterial efflux pump2010
- Author(s)
  Tsugawa, H., Suzuki, H.Saito, Y., et al
- Organizer
  AGA Research Forum DDW2010
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-22300169
[Presentation] Downregulation of the tumor suppressor microRNA-29c plays a critical role in the progression of human gastric cancer.2010
- Author(s)
  Saito Y, Suzuki H, Imaeda H, Matsuzaki J, Hirata K, Tsugawa H, Hosoe N, Hibi T.
- Organizer
  Digestive Disease Week Poster presentation
- Place of Presentation
  New Orleans, USA
- Year and Date
  2010-01-05
- Data Source
  KAKENHI-PROJECT-21790327
[Presentation] Chronic infection with Helicobacter pylori induces downregulation of muscle-specific microRNAs and smooth muscle hypertrophy of the mouse stomach.2010
- Author(s)
  Saito, Y., Suzuki, H., et al
- Organizer
  AGA Research Forum DDW2010
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-22300169
[Presentation] Chronic infection with Helicobacter pylori induces downregulation of muscle-specific microRNAs and smooth muscle hypertrophy of the mouse stomach.2010
- Author(s)
  Saito, Y., Suzuki, H., et al.
- Organizer
  Digestive Disease Week 2010
- Place of Presentation
  New Orleans, USA
- Year and Date
  2010-05-02
- Data Source
  KAKENHI-PROJECT-22300169
[Presentation] Upregulation of oncogenic microRNA-21followed by the downregulation of the tumor suppressor microRNA-29cin the progression of human gastric cancer.2010
- Author(s)
  Suzuki, H., Saito, Y., Kanai, Y., et al
- Organizer
  UEGW2010
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2010-10-25
- Data Source
  KAKENHI-PROJECT-22300169
[Presentation] Downregulation of the tumor suppressor microRNA-29cplays a critical role in the progression of human gastric cancer.2010
- Author(s)
  Saito, Y., Suzuki, H., et al.
- Organizer
  DDW2010
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-22300169
[Presentation] Chromatin remodehng at Alu repeats by epigenetic therapy activates silenced microRNAs in human gastric cancer cells.2009
- Author(s)
  Yoshimasa Saito, 他
- Organizer
  アメリカ消化器病学会(DDW 2009)
- Place of Presentation
  米国イリノイ州シカゴ
- Year and Date
  2009-06-03
- Data Source
  KAKENHI-PROJECT-21790327
[Presentation] Activation of Alu-associated microRNAs by epigenetic therapy of human gastric cancer cells (Oral presentation)2008
- Author(s)
  Saito Y, Suzuki H, Hibi T
- Organizer
  Digestive Disease Week
- Place of Presentation
  米国San Diego
- Year and Date
  2008-05-19
- Data Source
  KAKENHI-PROJECT-19599024
[Presentation] Activation of Alu-associated microRNAs by epigenetic therapy of human gastric cancer cells2008
- Author(s)
  Yosh imasa Saito, 他
- Organizer
  アメリカ消化器病学会(DDW 2008)
- Place of Presentation
  米国カリフォルニア州サンディェゴ
- Year and Date
  2008-05-19
- Data Source
  KAKENHI-PROJECT-19599024
[Presentation] マイクロRNAを標的とした胃がんに対するエピジェネティック治療2008
- Author(s)
  斎藤義正、鈴木秀和、日比紀文
- Organizer
  第16回浜名湖シンポジウム
- Place of Presentation
  静岡県浜名湖
- Year and Date
  2008-12-20
- Data Source
  KAKENHI-PROJECT-19599024
[Presentation] Silencing of microRNA-122 is an early event during hepatocarcinogenesis from nonalcoholic steatohepatitis
- Author(s)
  Saito Y, Takaki Y, Toshimitsu K, Takasugi A, Yamada S, Muramatsu T, Kimura M, Sugiyama K, Kanai T, Saito H.
- Organizer
  United European Gastroenterology Week　2014
- Place of Presentation
  Vienna, Austria
- Year and Date
  2014-10-20 – 2014-10-22
- Data Source
  KAKENHI-PROJECT-26290049
[Presentation] がんに対するエピジェネティック治療によるマイクロRNA発現変化の網羅的解析
- Author(s)
  齋藤義正
- Organizer
  日本分子腫瘍マーカー研究会
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-23680090
[Presentation] Suppression of Intestinal Tumor-Initiating Cells by Inhibition of DNA Methylation
- Author(s)
  Saito Y, Sakai K, Toshimitsu K, Muramatsu T, Kimura M, Sato T, Kanai T, Saito H
- Organizer
  United European Gastroenterology Week　2014
- Place of Presentation
  Vienna, Austria
- Year and Date
  2014-10-20 – 2014-10-22
- Data Source
  KAKENHI-PROJECT-26290049
[Presentation] DNAメチル化阻害による腸管腫瘍幹細胞の増殖抑制
- Author(s)
  利光孝太、齋藤義正、齋藤英胤
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26290049
[]

1. KANAI Yae (00260315)

# of Collaborated Projects: 5 results

# of Collaborated Products: 8 results
2. 新井恵吏 (40446547)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. SUZUKI Hidekazu (70255454)

# of Collaborated Projects: 2 results

# of Collaborated Products: 31 results
4. SATO Toshiro (70365245)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. OOE Tomoyuki (30624283)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. MATSUZAKI Juntaro (60464864)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
7. AKAIKE Toshihiro (30101207)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. ONISHI Yasuyuki (70201382)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SAITO Hidetsugu (80186949)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MASHINO Tadahiko (90165697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YAMAMOTO Naoki (40513289)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KATSUDA Takeshi (40732326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. OCHIYA Takahiro (60192530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TAKEUCHI Atsuko (80154970)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 山野友義 (40724183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 中山淳 (30801237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 山田泰弘

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 山口智子

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 保坂和徳

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. SUGIYAMA Kazuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
21. ITO Hidemi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. UMEZU Tomohiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. SATO Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. NAKAOKA Toshiaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 斎藤英胤

# of Collaborated Projects: 0 results

# of Collaborated Products: 14 results
26. 冨田謙吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 工藤篤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 寺谷俊昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. HOSSAIN M.S.

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. HOSSAIN Md. Shariff

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. HOSSAIN Md.Sharif

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Saito Yoshimasa 齋藤 義正

SAITO Yoshimasa 齋藤 義正

斎藤 義正 サイトウ ヨシマサ

Research Projects

Research Products

Co-Researchers

Multi-omics analysis - particularly epigenomic analysis - to elucidate the nature of NASH-derived hepatocellular carcinoma and identify therapeutic targets

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胆道がん腫瘍微小環境の再構築による次世代オルガノイドの開発Principal Investigator

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デザイナーエクソソームとオルガノイドを用いた個別化がん免疫療法の開発Principal Investigator

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国際協力による難治性がんオルガノイドライブラリーの構築Principal Investigator

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Comprehensive elucidation of the mechanism of circulating miRNA fluctuations during pancreatic carcinogenesis

Principal Investigator

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Discovery of novel therapeutic agents for biliary tract and pancreatic cancer based on antifungal agentsPrincipal Investigator

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Elucidation of Aging Mechanisms by Regulation of NAD+ and Epigenome and Development of New Anti-Aging InterventionsPrincipal Investigator

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Review Section

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Development of biliary and pancreatic tumor cell bank using organoid culture and its application to personalized therapyPrincipal Investigator

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Investigation of the molecular mechanism underlying aging based on epigenome alterations in intestinal epithelial stem cellsPrincipal Investigator

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Generation of hepatic progenitor cells from human hepatocytes using small molecules

Principal Investigator

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Diagnostic and therapeutic strategies targeting microRNAs and epigenome alterations in biliary tract and pancreatic cancer stem cellsPrincipal Investigator

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Analysis of epigenetic changes in hepatocellular carcinoma and an investigation for a new therapeutic modality targeting histone acetylation

Principal Investigator

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Identification of critical microRNAs in gastric cancer and application for epigenetic therapy.Principal Investigator

Principal Investigator

Saito Yoshimasa 齋藤義正

SAITO Yoshimasa 齋藤義正

斎藤義正サイトウヨシマサ