Mizuno Yuki 水野雄貴

… Alternative Names

MIZUNO Yuki 水野雄貴

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Researcher Number	90805194
Other IDs	https://orcid.org/0000-0001-8740-2261
Affiliation (Current)	2025: 北海道大学, アイソトープ総合センター, 助教
Affiliation (based on the past Project Information) *help	2020 – 2024: 北海道大学, アイソトープ総合センター, 助教 2017 – 2019: 昭和薬科大学, 薬学部, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 52040:Radiological sciences-related / Radiation science Except Principal Investigator Basic Section 52040:Radiological sciences-related / Medium-sized Section 52:General internal medicine and related fields / Radiation science
Keywords	Principal Investigator 多価効果 / 核医学治療 / インテグリン / 代謝性リンカー / 核医学診断 / ペプチド / がん / イソニトリル / インジウム-111 / テクネチウム-99m / メラノーマ / SPECT … More Except Principal Investigator … More 核医学 / セラノスティクス / PET / フェロトーシス / 放射線 / チミジンホスホリラーゼ / 核医学診断 / がん治療 / 空間線量率 / 線量評価 / 癌 / 治療用放射性薬剤 / 放射性代謝物 / 負電荷 / 多価ペプチド / アルブミンバインダー / 放射性医薬品 / ソマトスタチン / イメージンング / 不安定性評価 / 動脈硬化 / イメージング / 薬学 / がんのイメージング / がんイメージング / 細胞周期制御因子 / サイクリン依存性キナーゼ / CDK2 / がんのイメジング / 治療効果予測 / がん / トランスポーター / 個別化医療 / 有機カチオントランスポーター / イメージング剤 / 5-フルオロウラシル / がん治療効果予測 Less

Development of a New Dosimetry Technique Using Air Dose Rates for Nuclear Medicine Theranostics
- Principal Investigator
  
  渡邊史郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Hokkaido University
セラノスティクスを目的とした放射性標識ソマトスタチンアナログの体内動態の最適化
- Principal Investigator
  
  秋澤宏行
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Showa Pharmaceutical University
血管新生因子PD-ECGFを標的としたAt-211標識治療用放射性薬剤の基礎検討
- Principal Investigator
  
  西嶋剣一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Fukushima Medical University
多価効果と代謝性リンカーの融合による革新的核医学治療薬の開発Principal Investigator
- Principal Investigator
  
  水野雄貴
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Hokkaido University
Ferroptosis imaging with PET: Challenge to assess vulnerability of atherosclerotic plaques
- Principal Investigator
  
  KUGE YUJI
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Hokkaido University
PET imaging for cancer treatment inducing ferrotosis
- Principal Investigator
  
  久下裕司
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Hokkaido University
Development of radiolabeled multivalent RGD peptides which display high and persistent uptake in cancerous tissuesPrincipal Investigator
- Principal Investigator
  
  Mizuno Yuki
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Hokkaido University
Development of thymidine phosphorylase imaging techniques precisely targeted to the tumor for personalized medicine
- Principal Investigator
  
  Akizawa Hiromichi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Showa Pharmaceutical University
The development of 99mTc-labeled melanoma targeting imaging agents based on chelation mediated multivalencyPrincipal Investigator
- Principal Investigator
  
  MIZUNO Yuki
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Radiation science
- Research Institution
  Showa Pharmaceutical University
Development of a radioactive probe targeting the cell cycle regulatory factor CDK2
- Principal Investigator
  
  Kitaura Hirotake
- Project Period (FY)
  2017 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Health Sciences University of Hokkaido

All 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Application of copper (I) selective ligands for PET imaging of reactive oxygen species through metabolic trapping2024
- Author(s)
  Tada Tetsuro、Mizuno Yuki、Shibata Yuki、Yasui Hironobu、Kuge Yuji
- Journal Title
  
  Nuclear Medicine and Biology
  
  Volume: 134-135 Pages: 108914-108914
- DOI
  10.1016/j.nucmedbio.2024.108914
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K19433
[Journal Article] Influence of Linker Molecules in Hexavalent RGD Peptides on Their Multivalent Interactions with Integrin αvβ32021
- Author(s)
  Mizuno Yuki、Kimura Kohta、Onoe Satoru、Shukuri Miho、Kuge Yuji、Akizawa Hiromichi
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 64 Issue: 21 Pages: 16008-16019
- DOI
  10.1021/acs.jmedchem.1c01396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16803
[Presentation] Synthesis of [64Cu]Cu+ complex for redox imaging and evaluation of its reactivity with reactive oxygen species.2023
- Author(s)
  Tada T, Mizuno Y, Shibata Y, Yasui H, Kuge Y
- Organizer
  The 25th International Symposium of Radiopharmaceutical Sciences (iSRS 2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19433
[Presentation] 複数のintegrin αvβ3と同時結合可能な多価cRGDペプチドの開発と多様な放射性同位元素で標識可能な構造への展開2023
- Author(s)
  水野雄貴, 林龍昕, 尾江悟, 秋澤宏行, 久下裕司
- Organizer
  第6回日本核医学会分科会放射性薬品科学研究会
- Data Source
  KAKENHI-PROJECT-23K24268
[Presentation] Cystine-dense peptide TfRB1G3 のTfR1への親和性評価と68Ga標識に向けたHBED-CC結合体の合成2023
- Author(s)
  林龍昕、水野雄貴、久下裕司、柴田悠貴、安井博宣
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K19433
[Presentation] Cystine-dense peptide TfRB1G3 のTfR1への親和性評価と68Ga標識に向けたHBED-CC結合体の合成2023
- Author(s)
  林龍昕、水野雄貴、久下裕司、柴田悠貴、安井博宣
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-23K21417
[Presentation] The synthesis and evaluation of [68Ga]Ga-HBED-CC-TfRB1G3 for TfR1 imaging.2023
- Author(s)
  Lin L, Mizuno Y, Shibata Y, Yasui H, Kuge Y
- Organizer
  The 25th International Symposium of Radiopharmaceutical Sciences (iSRS 2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21417
[Presentation] 複数のintegrin αvβ3と同時結合可能な多価cRGDの化学構造：複数の細胞株を用いた検討2023
- Author(s)
  水野雄貴, 林龍昕, 尾江悟, 秋澤宏行, 久下裕司
- Organizer
  バイオメディカル分析科学シンポジウム
- Data Source
  KAKENHI-PROJECT-23K24268
[Presentation] 多価RGDペプチドが複数のintegrin αvβ3と同時結合するために重要な化学構造の探索2023
- Author(s)
  水野雄貴, 尾江悟, 宿里充穗, 秋澤宏行, 久下裕司
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-23K24268
[Presentation] トランスポーター高発現細胞を用いたチミジンホスホリラーゼ標的放射性プローブ[123I] IIMUの取り込み機構に関する検討2022
- Author(s)
  長谷川舞衣, 宿里充穗, 尾江悟, 水野雄貴, 久下裕司, 秋澤宏行
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K08105
[Presentation] ROSイメージングを目的とした[64Cu]Cu+錯体の合成と評価：配位子構造が錯体の安定性に与える影響2022
- Author(s)
  多田哲朗、水野雄貴、柴田悠貴、安井博宣、久下裕司
- Organizer
  第62回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19433
[Presentation] トランスフェリン受容体認識直鎖ペプチドを母体とした68Ga標識プローブの合成と評価2022
- Author(s)
  水野雄貴, 三浦春香, 安井博宣, 柴田悠貴, 大久保直登, 前原経, 武田宏司, 大西俊介, 久下裕司
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-23K21417
[Presentation] Cystine-dense peptideを母体としたTfR1イメージング薬剤開発に向けた基礎的検討2022
- Author(s)
  林龍昕、水野雄貴、柴田悠貴、安井博宣、久下裕司
- Organizer
  第8回北大・部局横断シンポジウム
- Data Source
  KAKENHI-PROJECT-21K19433
[Presentation] ROSイメージングを目的としたメタボリックトラップ型PETプローブの開発：CuI-BCA錯体の利用2022
- Author(s)
  多田哲朗, 水野雄貴, 柴田悠貴, 安井博宣, 久下裕司
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K19433
[Presentation] Development of 99mTc-labeled hexavalent c(RGDfK) peptide with optimized linker structure for in vivo imaging of integrin αvβ3.2022
- Author(s)
  Yuki Mizuno, Kohta Kimura, Satoru Onoe, Miho Shukuri, Yuji Kuge, Hiromichi Akizawa
- Organizer
  The Fourth International Symposium on Technetium and Other Radiometals in Chemistry and Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24268
[Presentation] トランスフェリン受容体認識直鎖ペプチドを母体とした68Ga標識プローブの合成と評価2022
- Author(s)
  水野雄貴, 三浦春香, 安井博宣, 柴田悠貴, 大久保直登, 前原経, 武田宏司, 大西俊介, 久下裕司
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K19433
[Presentation] レドックスイメージングを目的とした[64Cu][CuI(BCS)2]+の合成とROSとの反応性評価2022
- Author(s)
  多田哲朗、水野雄貴、柴田悠貴、安井博宣、久下裕司
- Organizer
  第5回日本核医学会分科会放射性薬品科学研究会
- Data Source
  KAKENHI-PROJECT-21K19433
[Presentation] Cystine-dense peptideを母体としたTfR1イメージング薬剤開発に向けた基礎的検討2022
- Author(s)
  林龍昕、水野雄貴、柴田悠貴、安井博宣、久下裕司
- Organizer
  第8回北大・部局横断シンポジウム
- Data Source
  KAKENHI-PROJECT-23K21417
[Presentation] ROSイメージングを目的としたメタボリックトラップ型PETプローブの開発：CuI-イソニトリル錯体の利用2021
- Author(s)
  多田哲朗, 水野雄貴, 柴田悠貴, 安井博宣, 久下裕司
- Organizer
  第7回北大・部局横断シンポジウム
- Data Source
  KAKENHI-PROJECT-21K19433
[Presentation] 68Ga標識トランスフェリン受容体認識ペプチドによるがんイメージングの検討2021
- Author(s)
  三浦春香, 水野雄貴, 髙橋春香, 大久保直登, 前原経, 久下裕司, 武田宏司, 大西俊介
- Organizer
  第7回北大・部局横断シンポジウム
- Data Source
  KAKENHI-PROJECT-21K19433
[Presentation] 多価RGDのリンカー構造がintegrin αvβ3陽性細胞との相互作用に及ぼす影響2021
- Author(s)
  水野雄貴、木村倖大、尾江悟、宿里充穂、久下裕司、秋澤宏行
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K16803
[Presentation] 2価環状RGDペプチドのスペーサ構造がintegrin αvβ3陽性細胞との相互作用に与える影響2021
- Author(s)
  水野雄貴, 宮本莉里, 尾江悟, 宿里充穂, 久下裕司, 秋澤宏行
- Organizer
  第4回日本核医学会分科会放射性薬品科学研究会
- Data Source
  KAKENHI-PROJECT-20K16803
[Presentation] 68Ga標識トランスフェリン受容体認識ペプチドによるがんイメージングの検討2021
- Author(s)
  三浦春香, 水野雄貴, 髙橋春香, 大久保直登, 前原経, 久下裕司, 武田宏司, 大西俊介
- Organizer
  第7回北大・部局横断シンポジウム
- Data Source
  KAKENHI-PROJECT-23K21417

1. KUGE YUJI (70321958)

# of Collaborated Projects: 5 results

# of Collaborated Products: 16 results
2. 安井博宣 (10570228)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
3. Akizawa Hiromichi (90311795)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. 宿里充穗 (20525571)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. 趙松吉 (80374239)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 尾江悟 (90756107)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. 小川美香子 (20344351)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 上原知也 (10323403)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 西嶋剣一 (60364254)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. Kitaura Hirotake (10281817)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 大倉一枝 (60094827)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 大島伸宏 (80508648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 東川桂 (10756878)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 横田千晶 (80300979)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 渡邊史郎 (10802415)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 平田健司 (30431365)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Mizuno Yuki 水野 雄貴

MIZUNO Yuki 水野 雄貴

Research Projects

Research Products

Co-Researchers

Development of a New Dosimetry Technique Using Air Dose Rates for Nuclear Medicine Theranostics

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

セラノスティクスを目的とした放射性標識ソマトスタチンアナログの体内動態の最適化

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

血管新生因子PD-ECGFを標的としたAt-211標識治療用放射性薬剤の基礎検討

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

多価効果と代謝性リンカーの融合による革新的核医学治療薬の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Ferroptosis imaging with PET: Challenge to assess vulnerability of atherosclerotic plaques

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

PET imaging for cancer treatment inducing ferrotosis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of radiolabeled multivalent RGD peptides which display high and persistent uptake in cancerous tissuesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of thymidine phosphorylase imaging techniques precisely targeted to the tumor for personalized medicine

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The development of 99mTc-labeled melanoma targeting imaging agents based on chelation mediated multivalencyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a radioactive probe targeting the cell cycle regulatory factor CDK2

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Application of copper (I) selective ligands for PET imaging of reactive oxygen species through metabolic trapping2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Influence of Linker Molecules in Hexavalent RGD Peptides on Their Multivalent Interactions with Integrin αvβ32021

Author(s)

Journal Title

DOI

Data Source

[Presentation] Synthesis of [64Cu]Cu+ complex for redox imaging and evaluation of its reactivity with reactive oxygen species.2023

Author(s)

Organizer

Data Source

[Presentation] 複数のintegrin αvβ3と同時結合可能な多価cRGDペプチドの開発と多様な放射性同位元素で標識可能な構造への展開2023

Mizuno Yuki 水野雄貴

MIZUNO Yuki 水野雄貴