• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Takahashi-Kanemitsu Atsushi  金光 昌史 (高橋 昌史)

… Alternative Names

高橋 昌史

高橋昌史

TAKAHASHI Atsushi  高橋 昌史

Less
Researcher Number 00624496
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-4156-9522
Affiliation (Current) 2025: 順天堂大学, 医学部, 助教
Affiliation (based on the past Project Information) *help 2025: 順天堂大学, 医学部, 助教
2019 – 2021: 東京大学, 大学院医学系研究科(医学部), 助教
2016: 東京大学, 大学院医学系研究科(医学部), 助教
2013 – 2015: 東京大学, 医学(系)研究科(研究院), 助教
2014: 東京大学, 大学院医学系研究科, 助教
2012: 東京大学, 医学(系)研究科(研究院), 研究員
2007 – 2008: Hokkaido University, 大学院・理学院, 特別研究員(DC2)
Review Section/Research Field
Principal Investigator
Basic Section 48040:Medical biochemistry-related / Molecular biology / Basic Section 38060:Applied molecular and cellular biology-related / Tumor biology / Tumor biology
Except Principal Investigator
Biological Sciences
Keywords
Principal Investigator
チロシンリン酸化 / 細胞内シグナル伝達 / 分子生物学 / プロテオミクス解析 / 機能獲得型変異 / 悪性形質転換 / SHP-2 / 胃発がん / ヘリコバクター・ピロリ(ピロリ菌) / CagAタンパク質 … More / Wnt-PCPシグナル伝達 / 頂底細胞極性/A-B細胞極性 / PAR1b/MARK2 / 平面内細胞極性/PCP極性 / Helicobacter pylori / ゲノム不安定性の誘導 / DNA傷害の相同組替え修復 / BRCA1 / Want-PCPシグナル伝達経路 / Hippoシグナル伝達系 / PAR1b / CagA / ヘリコバクター・ピロリ / 平面内細胞極性 / Wntシグナル伝達系 / YAP/TAZ / PTK6 / SHP2 / 選択的スプライシング / YAP / Wntシグナル伝達経路 / チロシン脱リン酸化酵素SHP2 / Parafibromin / Hippoシグナル経路 / Wntシグナル経路 / タンパク質チロシンリン酸化・脱リン酸化 / 遺伝子発現制御 / タンパク質リン酸化/脱リン酸化 / シグナル伝達 / がん … More
Except Principal Investigator
シグナル伝達 / 細菌 / 癌 / 炎症 / ヘリコバクター・ピロリ / 胃がん / 感染症 / がん Less
  • Research Projects

    (6 results)
  • Research Products

    (35 results)
  • Co-Researchers

    (8 People)
  •  血管スフェロイドの3次元形態を計測する腫瘍血管構造改変薬スクリーニング系の創出Principal Investigator

    • Principal Investigator
      金光 昌史 (高橋 昌史)
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      Juntendo University
  •  Understanding of the mechanism of gastric carcinogenesis by the development of the system that visualizes dynamics of the planar cell polarity within gastric epithelial organoidsPrincipal Investigator

    • Principal Investigator
      Takahashi-Kanemitsu Atsushi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 38060:Applied molecular and cellular biology-related
    • Research Institution
      The University of Tokyo
  •  Investigation of the medical/biological roles of the parafibromin functions regulated by SHP2 oncoproteinPrincipal Investigator

    • Principal Investigator
      TAKAHASHI Atsushi
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Tumor biology
    • Research Institution
      The University of Tokyo
  •  Investigation of the Roles of Dephosphorylated Parafibromin by SHP2 in OncogenesisPrincipal Investigator

    • Principal Investigator
      TAKAHASHI Atsushi
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Tumor biology
    • Research Institution
      The University of Tokyo
  •  Host response as an enhancer of infection-associated cancer and its regulation

    • Principal Investigator
      HATAKEYAMA Masanori
    • Project Period (FY)
      2010 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  チロシンホスファターゼSHP-2の細胞内新規標的分子の網羅的解析Principal Investigator

    • Principal Investigator
      高橋 昌史
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for JSPS Fellows
    • Research Field
      Molecular biology
    • Research Institution
      Hokkaido University

All 2021 2020 2019 2016 2015 2014 2013 2012 2011 2008

All Journal Article Presentation Book

  • [Book] 実験医学 11月号 発生・器官形成、がん悪性化に関わるHippoシグナル2015

    • Author(s)
      高橋昌史、畠山昌則
    • Total Pages
      6
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-15K18399
  • [Book] Hippo経路のエフェクター分子YAPおよびTAZによるがんタンパク質SHP2の機能制御2014

    • Author(s)
      高橋 昌史、堤 良平、畠山 昌則
    • Publisher
      細胞工学
    • Data Source
      KAKENHI-PLANNED-22114002
  • [Journal Article] Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis2021

    • Author(s)
      S Imai, T Ooki, N Murata-Kamiya, D Komura, K Tahmina, W Wu, Atsushi Takahashi-Kanemitsu, C T Knight, A Kunita, N Suzuki, A Del Valle, M Tsuboi, M Hata, Y Hayakawa, N Ohnishi, K Ueda, M Fukayama, T Ushiku, S Ishikawa, M Hatakeyama
    • Journal Title

      Cell Host & Microbe

      Volume: 29 Issue: 6 Pages: 1-18

    • DOI

      10.1016/j.chom.2021.04.006

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K05945, KAKENHI-PROJECT-19K07535, KAKENHI-PROJECT-21H04804, KAKENHI-PROJECT-20H03656, KAKENHI-PROJECT-20K07422, KAKENHI-PROJECT-21K19474, KAKENHI-PROJECT-21K15526, KAKENHI-PROJECT-20K09712
  • [Journal Article] Alternative splicing reverses the cell-intrinsic and cell-extrinsic pro-oncogenic potentials of YAP12020

    • Author(s)
      Chi Ben, Xiaojing Wu, Atsushi Takahashi-Kanemitsu, Christopher Takaya Knight, Takeru Hayashi, Masanori Hatakeyama
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 295 Issue: 41 Pages: 13965-13980

    • DOI

      10.1074/jbc.ra120.013820

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K05945, KAKENHI-PROJECT-16H06373, KAKENHI-PROJECT-18K07105
  • [Journal Article] Molecular anatomy and pathogenic actions of Helicobacter pylori CagA that underpin gastric carcinogenesis2020

    • Author(s)
      Atsushi Takahashi-Kanemitsu, Christopher T Knight, Masanori Hatakeyama
    • Journal Title

      Cellular & Molecular Immunology

      Volume: 17 Issue: 1 Pages: 50-63

    • DOI

      10.1038/s41423-019-0339-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K05945, KAKENHI-PROJECT-16H06373
  • [Journal Article] High-molecular-weight hyaluronan is a Hippo signal ligand that directs cell density-dependent growth inhibition via PAR1b.2019

    • Author(s)
      Ooki, T., Murata-Kamiya, N., Takahashi-Kanemitsu, A. and Hatakeyama, M.
    • Journal Title

      Developmental Cell

      Volume: 印刷中 Issue: 4 Pages: 590-604

    • DOI

      10.1016/j.devcel.2019.04.018

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H06373, KAKENHI-PROJECT-19K05945, KAKENHI-PROJECT-19K07535
  • [Journal Article] Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways.2016

    • Author(s)
      Kikuchi I, Takahashi-Kanemitsu A, Sakiyama N, Tang C, Tang PJ, Noda S, Nakao K, Kassai H, Sato T, Aiba A, and Hatakeyama M.
    • Journal Title

      Nat Commun

      Volume: 7 Issue: 1 Pages: 12887-12887

    • DOI

      10.1038/ncomms12887

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-25115010, KAKENHI-PROJECT-16H06373, KAKENHI-PROJECT-16J02902, KAKENHI-PROJECT-15K18399, KAKENHI-PROJECT-15K06701, KAKENHI-PROJECT-16K15273
  • [Journal Article] Determination of the catalytic activity of LEOPARD syndrome- associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling2016

    • Author(s)
      Saori Noda, Atsushi Takahashi, Takeru Hayashi, Sei-ichi Tanuma and Masanori Hatakeyama
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 469 Issue: 4 Pages: 1133-1139

    • DOI

      10.1016/j.bbrc.2015.12.117

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K18399, KAKENHI-ORGANIZER-22114001, KAKENHI-PROJECT-25250016, KAKENHI-PROJECT-15H04315, KAKENHI-PROJECT-25460156, KAKENHI-PROJECT-26860284, KAKENHI-PROJECT-16H06373, KAKENHI-PROJECT-16K15273
  • [Journal Article] YAP and TAZ, Hippo signaling targets, act as a rheostat for nuclear SHP2 function.2013

    • Author(s)
      Tsutsumi, D., Masoodi, M., Takahashi, A., Fujii, Y., Hayashi, T, . Kikuchi, I., et al.
    • Journal Title

      Developmental Cell

      Volume: 26(6) Issue: 6 Pages: 658-665

    • DOI

      10.1016/j.devcel.2013.08.013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J04126, KAKENHI-ORGANIZER-22114001, KAKENHI-PLANNED-22114002, KAKENHI-PROJECT-24700965, KAKENHI-PROJECT-25250016, KAKENHI-PROJECT-25251026
  • [Journal Article] SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver2011

    • Author(s)
      Takahashi A.、Tsutsumi R.、Kikuchi I.、 Obuse C.、Saito Y.、Seidi A.、Karisch R.、 Fernandez M.、Cho T.、Ohnishi N.、 Rozenblatt-Rosen O.、Meyerson M.、Neel B.G.、Hatakeyama M.
    • Journal Title

      Molecular cell

      Volume: 43(1) Issue: 1 Pages: 45-56

    • DOI

      10.1016/j.molcel.2011.05.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20114006, KAKENHI-ORGANIZER-22114001, KAKENHI-PLANNED-22114002, KAKENHI-PROJECT-22240085, KAKENHI-PROJECT-22700877
  • [Presentation] チロシン脱リン酸化酵素SHP2による形態形成シグナルの制御機構2021

    • Author(s)
      金光(髙橋) 昌史
    • Organizer
      順天堂大学大学院医学研究科 生化学・生体システム医科学講座セミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K05945
  • [Presentation] LEOPARD症候群由来変異型SHP2ホスファターゼのparafibrominに対する触媒活性の同定2016

    • Author(s)
      野田沙織、高橋昌史、林 剛瑠、畠山昌則
    • Organizer
      第75回 日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-15K18399
  • [Presentation] LEOPARD症候群特異的変異型SHP2のin vitro脱リン酸化試験による酵素活性解析2016

    • Author(s)
      野田沙織、高橋昌史、林剛瑠、田沼靖一、畠山昌則
    • Organizer
      日本薬学会 第136年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-15K18399
  • [Presentation] Parafibromin転写足場タンパク質機能のリン酸化依存的制御2016

    • Author(s)
      菊地逸平、高橋昌史、畠山昌則
    • Organizer
      第75回 日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-15K18399
  • [Presentation] Parafibromin acts as a signaling hub that orchestrates the Wnt, Hedgehog and Notch signaling pathways2015

    • Author(s)
      菊地逸平、高橋昌史、野嶋奈津紀、畠山昌則
    • Organizer
      第74回 日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-15K18399
  • [Presentation] LEOPARD症候群特異的変異型SHP2のチロシンホスファターゼ活性解析2014

    • Author(s)
      野田沙織, 高橋昌史, 林剛瑠, 畠山昌則
    • Organizer
      第6回日本プロテインホスファターゼ研究会学術集会
    • Place of Presentation
      三重大学
    • Data Source
      KAKENHI-PROJECT-24700965
  • [Presentation] LEOPARD症候群特異的変異型SHP2のチロシンホスファターゼ活性解析2014

    • Author(s)
      野田沙織、高橋昌史、林剛瑠、畠山昌則
    • Organizer
      第6回 日本プロテインホスファターゼ研究会 学術集会
    • Place of Presentation
      三重大学
    • Data Source
      KAKENHI-PROJECT-24700965
  • [Presentation] YAP1-mRNAの選択的スプライシングによるSHP2/YAP1相互作用の制御2014

    • Author(s)
      高橋昌史, 堤良平, マサウディムハンマド, 林剛瑠, 畠山昌則
    • Organizer
      がん研究分野の特性等を踏まえた支援活動公開シンポジウム
    • Place of Presentation
      一橋記念講堂(学術総合センター)
    • Data Source
      KAKENHI-PROJECT-24700965
  • [Presentation] YAP1-mRNAの選択的スプライシングによるSHP2/YAP1相互作用の制御2014

    • Author(s)
      高橋昌史、堤良平、Mohammad Masoudi、林剛瑠、畠山昌則
    • Organizer
      がん研究分野の特性等を踏まえた支援活動 公開シンポジウム
    • Place of Presentation
      一橋記念講堂(学術総合センター)
    • Data Source
      KAKENHI-PROJECT-24700965
  • [Presentation] YAP1-mRNAの選択的スプライシングによるSHP2/YAP1相互作用の制御2014

    • Author(s)
      高橋 昌史
    • Organizer
      がん研究分野の特性等を踏まえた支援活動 公開シンポジウム
    • Place of Presentation
      学術総合センタ-、東京
    • Data Source
      KAKENHI-PLANNED-22114002
  • [Presentation] SHP2 tyrosine phosphatase converts parafibromin/ Cdc73 from a tumor suppressor to an oncogenic driver.2014

    • Author(s)
      高橋昌史
    • Organizer
      c
    • Place of Presentation
      三重大学
    • Data Source
      KAKENHI-PROJECT-24700965
  • [Presentation] SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver2014

    • Author(s)
      高橋昌史
    • Organizer
      第6回日本プロテインホスファターゼ研究会学術集会
    • Place of Presentation
      三重大学
    • Data Source
      KAKENHI-PROJECT-24700965
  • [Presentation] LEOPARD症候群由来変異型SHP2ホスファターゼのin vitro酵素活性解析2013

    • Author(s)
      野田沙織、高橋昌史、林剛瑠、堤良平、畠山昌則
    • Organizer
      第72回 日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-24700965
  • [Presentation] Regulation of SHP2-YAP Interaction by Differential Splicing of YAP mRNA2013

    • Author(s)
      Mohammad Masoudi, Ryouhei Tsutsumi, Takeru Hayashi, Atsushi Takahashi, and Masanori Hatakeyama
    • Organizer
      The 4th JCA-AACR Special Joint Conference
    • Place of Presentation
      Tokyo Bay Maihama Hotel Club Resort
    • Data Source
      KAKENHI-PROJECT-24700965
  • [Presentation] LEOPARD症候群由来変異型SHP2ホスファターゼのin vitro酵素活性解析2013

    • Author(s)
      野田沙織, 高橋昌史, 林剛瑠, 堤良平, 畠山昌則
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-24700965
  • [Presentation] Tyrosine Phosphatase Activity of SHP2 Mutants Derived from LEOPARD Syndrome2013

    • Author(s)
      Saori Noda, Atsushi Takahashi, Takeru Hayashi, Ryouhei Tsutsumi, and Masanori Hatakeyama
    • Organizer
      The 4th JCA-AACR Special Joint Conference
    • Place of Presentation
      Tokyo Bay Maihama Hotel Club Resort
    • Data Source
      KAKENHI-PROJECT-24700965
  • [Presentation] Tyrosine Phosphatase Activity of SHP2 Mutants Derived from LEOPARD Syndrome2013

    • Author(s)
      S.Noda, A.Takahashi, T.Hayashi, R.Tsutsumi, M.Hatakeyama
    • Organizer
      The 4^<th> JCA-AACR Special Joint Conference
    • Place of Presentation
      Tokyo Bay Maihama Hotel Club Resort
    • Data Source
      KAKENHI-PROJECT-24700965
  • [Presentation] Regulation of SHP2-YAP Interaction by Differential Splicing of YAP mRNA2013

    • Author(s)
      M.Masoudi, R.Tsutsumi, T.Hayashi, A.Takahashi, M.Hatakeyama
    • Organizer
      The 4^<th> JCA-AACR Special Joint Conference
    • Place of Presentation
      Tokyo Bay Maihama Hotel Club Resort
    • Data Source
      KAKENHI-PROJECT-24700965
  • [Presentation] 複数のチロシンキナーゼによるSHP2/parafibromin依存的Wntシグナル活性化の拮抗制御2012

    • Author(s)
      高橋 昌史、齊藤 康弘、畠山 昌則
    • Organizer
      第71回 日本癌学会学術総会
    • Place of Presentation
      北海道札幌市 ロイトン札幌
    • Data Source
      KAKENHI-PROJECT-24700965
  • [Presentation] Involvement of multiple tyrosine kinases in antagonizing parafibromin-mediated activation of Wnt signaling by SHP22012

    • Author(s)
      Atsushi Takahashi
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌文芸館、札幌市
    • Year and Date
      2012-09-19
    • Data Source
      KAKENHI-PLANNED-22114002
  • [Presentation] がんタンパク質SHP2によりCdc73/parafibromin脱リン酸化を介したWnt経路活性化機構2012

    • Author(s)
      高橋昌史、畠山昌則
    • Organizer
      第三次対がん10か年総合戦略・文科省がん支援活動合同シンポジウム
    • Place of Presentation
      学術総合センター・一橋記念講堂(東京都)
    • Year and Date
      2012-01-30
    • Data Source
      KAKENHI-PLANNED-22114002
  • [Presentation] 複数のチロシンキナーゼによるSHP2/parafibromin依存的Wntシグナル活性化の拮抗制御2012

    • Author(s)
      高橋昌史, 齊藤康弘, 畠山昌則
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌市教育文化会館・ロイトン札幌・さっぽろ芸文館
    • Data Source
      KAKENHI-PROJECT-24700965
  • [Presentation] SHP2 oncoprotein activates nuclear Wnt signaling via dephosphorylation of a novel substrate, parafibromin/Cdc732011

    • Author(s)
      Takahashi A
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-05
    • Data Source
      KAKENHI-PLANNED-22114002
  • [Presentation] 固形腫瘍におけるSHP-2を介した悪性形質転換誘導メカニズムの解析2008

    • Author(s)
      高橋昌史
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-30
    • Data Source
      KAKENHI-PROJECT-07J03878
  • [Presentation] 固形腫瘍に由来する発癌性RAS様形質転換能を示す変異型SHP-2の機能解析2008

    • Author(s)
      高橋昌史
    • Organizer
      日本分子生物学会第8回春季シンポジウム
    • Place of Presentation
      京王プラザホテル札幌
    • Year and Date
      2008-05-26
    • Data Source
      KAKENHI-PROJECT-07J03878
  • 1.  HATAKEYAMA Masanori (40189551)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 2.  KAMIYA Naoko (40279352)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  MUTOH Hiroyuki (50322392)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  TSUTSUMI Ryohei (50435872)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  SAITO Yasuhiro (30613004)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  Sato Hirofumi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  饗場 篤
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  小布施 力史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

URL: 

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi