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Toyooka Naoki  豊岡 尚樹

… Alternative Names

TOYOOKA Naoki  豊岡 尚樹

豊岡 尚樹  トヨオカ ナオキ

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Researcher Number 10217565
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-9087-5414
External Links
Affiliation (Current) 2025: 富山大学, 学術研究部工学系, 教授
Affiliation (based on the past Project Information) *help 2023 – 2024: 富山大学, 学術研究部工学系, 教授
2017: 富山大学, 大学院理工学研究部, 教授
2012 – 2017: 富山大学, 大学院理工学研究部(工学), 教授
2013: 富山大学, 大学院医学薬学研究部(工学), 教授
2010 – 2013: 富山大学, 大学院・理工学研究部(工学), 教授 … More
2012: 富山大学, その他の研究科, 教授
2009: University of Toyama, 大学院・医学薬学研究部(薬学), 准教授
2007 – 2008: University of Toyama, 大学院・医学薬学研究部, 准教授
2006: 富山大学, 大学院医学薬学研究部, 助教授
2005: 富山大学, 薬学部, 助教授
2001: TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY, Faculty of Pharmaceutical Sciences Associate Professor, 薬学部, 助教授
2000: 富山医科薬科大学, 薬学部, 助手
1994: 富山医科薬科大学, 薬学部, 助手
1992: 富山医料薬科大学, 薬学部, 助手
1991 – 1992: 富山医科薬科大学, 薬学部, 助手 Less
Review Section/Research Field
Principal Investigator
Drug development chemistry / Chemical pharmacy / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Chemical pharmacy
Except Principal Investigator
Chemical pharmacy / Drug development chemistry / Basic Section 47060:Clinical pharmacy-related / Physical pharmacy / Neurochemistry/Neuropharmacology / General pharmacology / Pain science
Keywords
Principal Investigator
LC3-GST cleavage assay / システインプロテアーゼ / オートファジー / 構造―活性相関 / in silicoスクリーニング / Atg4B阻害剤 / オートファジー阻害剤 / トリアゾール / メタ置換ベンゼン / 3T3-L1脂肪細胞 … More / Echelon社 / Aktのリン酸化 / CP-3 / CP-2 / 3T3-L1 / インシリコスクリーニング / SHIP2阻害 / ファーマコフォア / Akt / SHIP2 / インスリン抵抗性改善薬 / 新規アミド型化合物 / 擬態 / フコシダーゼ阻害剤 / ラムノシダーゼ / フコシダーゼ / ポリヒドロキシピロリチジン / エナンチオダイバージェントストラテジー / inhibitors / rhamnosidase / fucosidase / ジアステレオマー / 不斉アリル化 / 海綿 / 立体化学 / 絶対配置 / 相対配置 / Batzellaside / クロスメタセシス / 環状カーバメート / バツェラサイド / 海洋産アルカロイド / 5,8位置換インドリチジン / NIH / 221K / 251N / インドリチジン / 251AA / 235U / 233A / epi-193E / 221I / 231C / monomorine I / ヒドロキシインドリチジン / 207E / 179 / ニコチン受容体 / 毒ガエルアルカロイド / elemal / 矢毒ガエルアルカロイド / spicigerine / 新規汎用性キラル素子 … More
Except Principal Investigator
(-)-indolizidine 223AB / (+)-monomorine I / 創薬 / MCT / クレアチン / 血液脳関門 / プロドラッグ / モノカルボン酸トランスポーター / ドラッグデザイン / 結合自由エネルギー計算 / ファーマコフォア / インシリコスクリーニング / アルツハイマー型認知症 / インスリン / 糖尿病 / 相互作用エネルギー計算 / 分子ドッキング計算 / イン・シリコスクリーニング / 阻害剤 / SHIP2 / 阻害選択性の向上 / 構造安定性低下 / SNPs / 抗癌剤耐性克服 / 分子モデリング / 構造活性相関 / AKR1B10 / SNP / 抗癌剤 / アルドケト還元酵素 / Maxadilan / アンタゴニスト / 核内受容体 / ケモカイン / 神経障害性疼痛 / 慢性疼痛 / マイクロアレイ / 脊髄後角 / アロディニア / PAC1受容体 / PACAP / Sendai virus / retro-electron-demanded Diels-Alder reaction / dihydrofuran / benzocyclobutene / o-quinozimethane / anti-virus activity / sodium salt of sulfate / halenaouinol / 抗ウィルス剤 / フラン環 / アマンタジン / 四環系化合物 / 分子内環化付加反応 / 多環系天然物 / Sendaiウイルス / 逆電子要請型環化付加反応 / ジヒドロフラン / ベンゾシクロブテン / オルトキノジメタン / 抗ウイルス活性 / モノサルフェートナトリウム塩 / ハレナキノール / functionalized 3-piperidinol / sigma-symmetric ring-crossed glycol / 'fork head' ketone / bridged bicyclic compound / エナンチオダイバ-ジェント合成 / テコマアルカロイド / (ー)ーインドリチジン223AB / (+)ーモノモリンI / “fork head"位ケトン / α,α'位シス置換3ーピペリジノール / σ対称型双環系ジオール / (+)-monomorineI / δ対称型双環系グリコール / (-)-indoliZidine223AB / (+)-dihyropinidine / 'fork head'位ケトン / 架橋双環系分子 / NMDA受容体 / 神経変性疾患 / 興奮性神経毒性 / マウスモデル / セリンラセマーゼ / D-セリン / 乾皮症 / 胆汁うっ滞 / アセチルコリン / 受け身アナフィラキシー / 掻破 / PAR2受容体拮抗薬 / PAR2受容体 / プロテアーゼ / そう痒性疾患 / 痒み / PANC-1 / アルクチゲニン / 抗がん剤 / 膵臓がん / 和漢薬 / 栄養飢餓耐性 / 癌 / 医薬品化学 Less
  • Research Projects

    (15 results)
  • Research Products

    (65 results)
  • Co-Researchers

    (33 People)
  •  脳クレアチン供給を実現するモノカルボン酸輸送体認識型プロドラッグ開発とその有用性

    • Principal Investigator
      細谷 健一
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      University of Toyama
  •  Research and development of autophagy-specific inhibitorsPrincipal Investigator

    • Principal Investigator
      豊岡 尚樹
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
    • Research Institution
      University of Toyama
  •  Studies on novel insulin-sensitizing agent based on SHIP2 inhibitorsPrincipal Investigator

    • Principal Investigator
      Toyooka Naoki
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      University of Toyama
  •  Discovery of SHIP2 inhibitors for novel drugs against type 2 diabetes accompanying dementia of Alzheimer's type

    • Principal Investigator
      GOUDA Hiroaki
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      Showa University
  •  Elucidation of the mechanisms of chronic pain by PAC1 receptor and drug discovery.

    • Principal Investigator
      TAKASAKI ICHIRO
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      University of Toyama
  •  Development of novel anticancer agents targeting survival strategy of cancer cells

    • Principal Investigator
      Endo Satoshi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      Gifu Pharmaceutical University
  •  Analysis of D-serine dynamics in the brain and development of novel drugs against excitotoxicity

    • Principal Investigator
      Mori Hisashi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      University of Toyama
  •  Synthetic Studies on novel fucosidase and rhamnosidase inhibitorsPrincipal Investigator

    • Principal Investigator
      TOYOOKA naoki
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      University of Toyama
  •  Roles of proteases and proteinase-activated receptor 2 in itching of pruritic diseases

    • Principal Investigator
      KURAISHI Yasushi
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pain science
    • Research Institution
      University of Toyama
  •  Development of a new pancreatic cancer curative medicine from arctigenin, an ingredient of Wakan-yaku "Burdock Fruit (Seeds of Arctium lappa)"

    • Principal Investigator
      TEZUKA Yasuhiro
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      University of Toyama
  •  Synthetic Studies on Marine Alkaloid of Batzellasides Directed toward Novel Antidiabetic DrugPrincipal Investigator

    • Principal Investigator
      TOYOOKA Naoki
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      University of Toyama
  •  Synthetic Studies on Poison-frog Alkaloids As Antagonists on nicotinic Acetylcholine ReceptorsPrincipal Investigator

    • Principal Investigator
      TOYOOKA Naoki
    • Project Period (FY)
      2005 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      University of Toyama
  •  Synthetic Studies on Furan-fused Polycyclic Natural Products and Its Derivatives

    • Principal Investigator
      NEMOTO Hideo
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
  •  跨環型o′対照ジオールの環不斉識別による新規汎用性キラル素子の創製Principal Investigator

    • Principal Investigator
      豊岡 尚樹
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Toyama Medical and Pharmaceutical University
  •  Design of Versatile Chiral Building Blocks via Asymmetric Cleavage of the Bridged Bicyclic Ketone and Its Applications to the Natural Product Synthesis

    • Principal Investigator
      MOMOSE Takefumi
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY

All 2023 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation Patent

  • [Journal Article] In silico and pharmacological screening identify novel PAC1 receptor antagonists.2016

    • Author(s)
      Watanabe A, Okada T, Fukuchi M, Gouda H, Kurihara T, Miyata A, Toyooka N, Takasaki I.
    • Journal Title

      J Pharmacol Sci

      Volume: 30

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26430067
  • [Journal Article] Synthesis of 8-hydroxy-2-iminochromene derivatives as selective and potent inhibitors of human carbonyl reductase 12015

    • Author(s)
      Dawei Hu, Namiki Miyagi, Yuki Arai, Hiroaki Oguri, Takeshi Miura, Toru Nishinaka, Tomoyuki Terada, Hiroaki Gouda, Ossama El-Kabbani, Shuang, Xia, Naoki Toyooka, Akira Hara, Toshiyuki Matsunaga, Akira Ikari, Satoshi Endo
    • Journal Title

      Org. Biomol. Chem.

      Volume: 13 Pages: 7487-7499

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460149
  • [Journal Article] Enantiodivergent strategy for the synthesis of polyhydroxylated pyrrolizidines and evaluation of their inhibitory activities against glycosidases2015

    • Author(s)
      Minehira, D.*; Okada, T.; Iwaki, R.; Kato, A.; Adachi, I.; Toyooka, N.*
    • Journal Title

      Tetrahedron Lett.

      Volume: 56 Issue: 2 Pages: 331-334

    • DOI

      10.1016/j.tetlet.2014.11.087

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24590138
  • [Journal Article] In silico and pharmacological screenings identify novel serine racemase inhibitors.2014

    • Author(s)
      Hisashi Mori, Ryogo Wada, Jie Li, Tetsuya Ishimoto, Mineyuki Mizuguchi, Takayuki Obita, Hiroaki Gouda, Shuichi Hirono, Naoki Toyooka.
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 24 Issue: 16 Pages: 3732-3735

    • DOI

      10.1016/j.bmcl.2014.07.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590058, KAKENHI-PROJECT-25293059, KAKENHI-PROJECT-26840018
  • [Journal Article] Synthesis and antitumor evaluation of arctigenin derivatives based on antiausterity strategy2013

    • Author(s)
      Kudou N., Taniguchi A., Sugimoto A., Matsuya Y., Kawasaki M., Toyooka N., Miyoshi C., Awale S., Dibwe D.F., Esumi H., Kadota S., and Tezuka Y
    • Journal Title

      Eur. J. Med. Chem

      Volume: 60 Pages: 76-88

    • DOI

      10.1016/j.ejmech.2012.11.031

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590098
  • [Journal Article] Synthesis of Phenylalkyl Substituted Polyhydroxypiperidines as Potent Inhibitors for α-L-Fucosidases2013

    • Author(s)
      Saka, T.; Okaki, T.; Ifuku, S.; Yamashita, Y.; Sato, K.; Miyawaki, S.; Kamori, A.; Kato, A.*; Adachi, I.; Kiria, P. G.; Onomura, O.; Minato, D.; Sugimoto, K.; Matsuya, Y.; Toyooka, N.*
    • Journal Title

      Tetrahedron

      Volume: 69 Issue: 49 Pages: 10653-10661

    • DOI

      10.1016/j.tet.2013.10.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590138
  • [Journal Article] Synthesis and biological evaluation of N-(2-fluorophenyl)-2β-deoxyfuconojirimycin acetamide as a potent inhibitor for α-L-fucosidases2013

    • Author(s)
      Kato, A.*; Okaki, T.; Ifuku, S.; Sato, K.; Hirokami, Y.; Iwaki, R.; Kamori, A.; Nakagawa, S.; Adachi, I.; Kiria, P. G.; Onomura, O.; Minato, D.; Sugimoto, K.; Matsuya, Y.; Toyooka, N.*
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 21 Issue: 21 Pages: 6565-6573

    • DOI

      10.1016/j.bmc.2013.08.028

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590138
  • [Journal Article] First Enantioselective Synthesis of a Hydroxyindolizidine Alkaloid from the Ant2009

    • Author(s)
      Toyooka, N.* ; Zhou, D. ; Nemoto, H. ; Tezuka, Y. ; Kadota, S. ; Jones, T.H. ; Garraffo, H.M. ; Spande, T.F. ; Daly, J.W.
    • Journal Title

      Myrmicaria melanogaster Synlett

      Pages: 1894-1896

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Journal Article] Synthesis, Determination of the Absolute Stereochemistry, and Evaluations at the Nicotinic Acetylcholine Receptors of a Hydroxy-indolizidine Alkaloid from the Ant2009

    • Author(s)
      Zhou, D. ; Toyooka, N.* ; Nemoto, H. ; Yamaguchi, K. ; Tsuneki, H. ; Wada, T. ; Sasaoka, T. ; Sakai, H. ; Tezuka, Y. ; Kadota, S. ; Jones, T.H. ; Garraffo, H.M. ; Spande, T.F. ; Daly, J.W.
    • Journal Title

      Myrmicaria melanogaster Heterocycles 79

      Pages: 565-571

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Journal Article] Nemoto, H Enantioselective Syntheses of(-)-and(+)-Monomorine I2008

    • Author(s)
      Toyooka, N.* ; Zhou, D.
    • Journal Title

      J. Org. Chem 73

      Pages: 4575-4577

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Journal Article] First Enantioselective Synthesis of a Hydroxyindolizidine Alkaloid from the Ant Myrmicaria melanogaster2008

    • Author(s)
      Toyooka. N., Zhou, D., Nemot, H., Tezuka, Y., Kadota, S., Jones, T. H., Garraffo, H. M., Spande, T. F., Daly, J. W.
    • Journal Title

      Synlett

      Pages: 1894-1896

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Journal Article] Synthesis of the Proposed Structure of Poison-Frog Alkaloids 179 and 207Eand Their Inhibitory Effects on Neuronal Nicotinic Acetylcholine Receptors2008

    • Author(s)
      Toyooka, N.* ; Zhou, D. ; Kobayashi, S. ; Tsuneki, H. ; Wada, T. ; Sakai, H. ; Nemoto, H. ; Sasaoka, T. ; Tezuka, Y. ; Subehan ; Kadota, S. ; Garraffo, H.M. ; Spande, T.F. ; Daly, J.W.
    • Journal Title

      Synlett

      Pages: 61-64

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Journal Article] Synthesis of the Proposed Structure of Poison-Frog Alkaloids 179 and 207E and Their Inhibitory Effects on Neuronal Nicotinic Acetylcholine Receptors2008

    • Author(s)
      Toyooka, N., Zhou, D., Kobaya shi, S., Tsuneki, H., Wada, T., Sakai, H., Nemoto, H., Sasaoka, T., Tezuka, Y., Subehan, Kadota, S., Garraffo, H. M., Spande, T. F., Daly, J. W.
    • Journal Title

      Synlett

      Pages: 61-64

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Journal Article] Enantioselective Syntheses of (-)-and (+)-Monomorine I2008

    • Author(s)
      Toyooka, N., Zhou D., Nemoto, H.
    • Journal Title

      J. Org. Chem. 73

      Pages: 4575-4577

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Journal Article] Synthesis of Poison-frog Alkaloids and Their Pharmacolo gical Effects at Neuronal Nicotinic Acetylcholine Receptors2007

    • Author(s)
      Toyooka, N.^*; Tsuneki, H.; Kobayashi, S.; Dejun, Z.; Kawasaki, M.; Kimura, K.; Sasaoka, T.; Nemoto H.
    • Journal Title

      Current Chemical Biology 1

      Pages: 97-114

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Journal Article] Flexible Synthesis of Poison-frog Alkaloids of the 5, 8-Disubstituted Indolizidine-class. II: Synthesis of(-)-209B, (-)-231C, (-)-233D, (-)-235B', (-)-221I, and an Epimer of 193E and Pharmacological Effects at Neuronal Nicotinic Acetylcholine Receptors2007

    • Author(s)
      Kobayashi, S. ; Toyooka, N.* ; Zhou, D. ; Tsuneki, H.* ; Wada, T. ; Sasaoka, T. ; Sakai, H. ; Nemoto, H. ; Garraffo, H.M. ; Spande, T.F. ; Daly, J.W.
    • Journal Title

      Beilstein J. Org. Chem 3

      Pages: 30-30

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Journal Article] Synthesis of Poison-frog Alkaloids and Their Pharmacological Effects at Neuronal Nicotinic Acetylcholine Receptors2007

    • Author(s)
      Toyooka, N.* ; Tsuneki, H. ; Kobayashi, S. ; Dejun, Z. ; Kawasaki, M. ; Kimura, K. ; Sasaoka, T. ; Nemoto, H.
    • Journal Title

      Current Chemical Biology 1

      Pages: 97-114

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Journal Article] Rexlble Synthesis of Poison-frog Aikaloids of the 5,8-Disubstituted Indolizidine-class. II: Synthesis of(-)-209B, (-)-231C, (-)-233D, (-)-235B'',(-)-221I, and an Epimer of 193E and Pharmacological Effects at Neuronal Nicotinlc Acetylcholine Receptors2007

    • Author(s)
      Kobayashl, S.; Toyooka, N.^*; Zhou, D.; Tsuneki, H.; Wada, T.; Sasaoka, T.; Sakai, H.; Nemoto, H.; Garraffo, H. M.; Spande, T. F.; Daly, J. W.
    • Journal Title

      Beilstein J. Org. Chem 3(online journal)

      Pages: 30-30

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Journal Article] Flexible Synthetic Routes to Poison-frog Alkaloids of the 5,8- Disubstituted Indolizidine-class. I.: Synthesis of Common Lactam Chiral Building Blocks and Application to the Synthesis of(-)-203A, (-)-205A, and(-)-219F2007

    • Author(s)
      Toyooka, N.* ; Zhou, D. ; Nemoto, H. ; Garraffo, H.M. ; Spande, T.F. ; Daly, J.W.
    • Journal Title

      Beilstein J. Org. Chem 3

      Pages: 29-29

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Journal Article] Synthesis of Poison-frog Alkaloids 233A,235U, and 251AA and Their Inhibitory Effbcts on Neuronal Nicotinic Acetyicholine Receptors2007

    • Author(s)
      Toyooka, N.^*; Kobayashi, S.; Zhou, D.; Tsuneki, H.; Wada, T.; Sakai, H.; Nemoto, H.; Sasaoka, T.; Garraffo, H. M.; Spande, T. F, ; Daly, J. W.
    • Journal Title

      Bioorg. Med. Chem. Lett 17

      Pages: 5872-5875

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Journal Article] Synthesis of Poison-frog Alkaloids 233A, 235U, and 251AA and Their Inhibitory Effects on Neuronal Nicotinic Acetylcholine Receptors2007

    • Author(s)
      Toyooka, N.* ; Kobayashi, S. ; Zhou, D. ; Tsuneki, H. ; Wada, T. ; Sakai, H. ; Nemoto, H. ; Sasaoka, T. ; Garraffo, H.M. ; Spande, T.F. ; Daly, J.W.
    • Journal Title

      Bioorg. Med. Chem. Lett 17

      Pages: 5872-5875

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Journal Article] 毒ガエルアルカロイドの合成とニコチン受容体に対する活性評価2006

    • Author(s)
      豊岡 尚樹, 根本 英雄, 恒枝 宏史
    • Journal Title

      有機合成化学協会誌 64

      Pages: 49-60

    • NAID

      10016925229

    • Data Source
      KAKENHI-PROJECT-17590004
  • [Journal Article] The Enantioselective Synthesis of Poison-Frog Alkaloids(-)-203A, (-)-209B,(-)-231C, (-)-233D, and(-)-235B2006

    • Author(s)
      Toyooka, N.* ; Dejun, Z. ; Nemoto, H.* ; Garraffo, H.M. ; Spande, T.F. ; Daly, J.W.
    • Journal Title

      Tetrahedron Lett 47

      Pages: 577-580

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Journal Article] Enantioselective Syntheses of Poison-Frog Alkaloids : 219F and 221I and an Epimer of 193E2006

    • Author(s)
      Toyooka, N.* ; Dejun, Z. ; Nemoto, H.* ; Garraffo, H.M. ; Spande, T.F. ; Daly, J.W.
    • Journal Title

      Tetrahedron Lett 47

      Pages: 581-582

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Journal Article] 毒ガエルアルカロイドの合成とニコチン受容体に対する活性評価2006

    • Author(s)
      豊岡尚樹*、根本英雄、恒枝宏史
    • Journal Title

      有機合成化学協会誌 64

      Pages: 49-60

    • NAID

      10016925229

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Journal Article] Chiral Synthesis of Poison-Frog Alkaloids 251N2006

    • Author(s)
      Toyooka, N.* ; Dejun, Z. ; Nemoto, H.* ; Garraffo, H.M. ; Spande, T.F. ; Daly, J.W.
    • Journal Title

      and 221K Heterocycles 70

      Pages: 541-548

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Journal Article] Enantioselective syntheses of poison-frog alkaloids : 219F and 221I and an epimer of 193E2006

    • Author(s)
      Toyooka, N., Dejun, Z., Nemoto, H., Garraffo, H.M., Spande, T.F., Daly, J.W.
    • Journal Title

      Tetrahedron Lett. 47

      Pages: 581-582

    • Data Source
      KAKENHI-PROJECT-17590004
  • [Journal Article] Chiral Synthesis of Poison-frog Alkaloids 251N and 221K2006

    • Author(s)
      Toyooka, N., Zhou, d., Nemoto, H., Garraffo, H.M., Spande, T.F., Daly, J.W.
    • Journal Title

      Heterocycle 70

      Pages: 541-8

    • NAID

      40015208578

    • Data Source
      KAKENHI-PROJECT-17590004
  • [Journal Article] The enantioselective synthesis of poison-frog alkaloids (-)-203A, (-)-209B, (-)-231C, (-)-233D, and (-)-235B"2006

    • Author(s)
      Toyooka, N., Dejun, Z., Nemoto, H., Garraffo, H.M., Spande, T.F., Daly, J.W.
    • Journal Title

      Tetrahedron Lett. 47

      Pages: 577-580

    • Data Source
      KAKENHI-PROJECT-17590004
  • [Patent] AKR1B10阻害に基づく肺癌治療薬2016

    • Inventor(s)
      遠藤智史、松永俊之、五十里彰、豊岡尚樹、早川芳弘
    • Industrial Property Rights Holder
      岐阜市、富山大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-08-15
    • Data Source
      KAKENHI-PROJECT-26460149
  • [Patent] (Benzenesulfonylamino)benzamide derivative, and SHIP2 inhibitor containing same as active ingredient2015

    • Inventor(s)
      Toyooka, Goda他4名
    • Industrial Property Rights Holder
      Toyooka, Goda他4名
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015
    • Acquisition Date
      2017
    • Overseas
    • Data Source
      KAKENHI-PROJECT-15K08020
  • [Presentation] 前立腺がん治療の改善を目指した新規オートファジー特異的阻害剤の創製2023

    • Author(s)
      小林奈央, 工藤優大, 藤田芽衣, 吉野雄太, 松永俊之, 五十里彰, 遠藤智史, 岡田卓哉, 豊岡尚樹
    • Organizer
      第40回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-23K06024
  • [Presentation] 膵がんの抗がん剤耐性克服を目指した新規オートファジー阻害剤の開発2023

    • Author(s)
      工藤優大,廣田光太郎,都築歩乃佳,吉野雄太,小林奈央, 岡田卓哉, 豊岡尚樹,遠藤智史,五十里彰
    • Organizer
      第40回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-23K06024
  • [Presentation] ニトログリセリン誘発偏頭痛モデルマウスを用いた新規PAC1アンタゴニストの評価2017

    • Author(s)
      柴崎知華,渡辺 藍,栗原 崇,宮田篤郎,豊岡尚樹,髙﨑一朗
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホールほか
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-26430067
  • [Presentation] 新規鎮痛薬の開発を目指した核内受容体Nr4a1アンタゴニストの創製2017

    • Author(s)
      磯 芹奈,高原理行,合田浩明,宮田篤郎,栗原 崇,豊岡尚樹,髙﨑一朗
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホールほか
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-26430067
  • [Presentation] 種々疼痛モデルマウスにおける新規PAC1アンタゴニストの薬理学的評価2017

    • Author(s)
      長島涼太,上田隆拡,渡辺 藍,岡田卓哉,栗原 崇,宮田篤郎,豊岡尚樹,髙﨑一朗
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホールほか
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-26430067
  • [Presentation] 種々疼痛モデルマウスにおける新規PAC1受容体アンタゴニストの薬理学的評価2016

    • Author(s)
      長島涼太,上田隆拡,渡辺 藍,岡田卓哉,栗原 崇,宮田篤郎,豊岡尚樹,髙﨑一朗
    • Organizer
      日本薬学会北陸支部第128例会
    • Place of Presentation
      北陸大学薬学部アネックスホール
    • Year and Date
      2016-11-27
    • Data Source
      KAKENHI-PROJECT-26430067
  • [Presentation] AKR1B10 を標的とする抗癌剤開発を指向した構造活性相関研究2014

    • Author(s)
      陶山 美穂、遠藤 智史、松永 俊之、五十里 彰、胡 大イ、豊岡 尚樹
    • Organizer
      78回日本生化学会中部支部例会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-05-24
    • Data Source
      KAKENHI-PROJECT-26460149
  • [Presentation] フコシダーゼ阻害が期待されるアミド型イミノ糖の合成および活性評価2013

    • Author(s)
      伊福 翔平・岡城 徹・中川 進平・加藤 敦・足立 伊佐雄・Peter G. Kirira・尾野村 治・豊岡 尚樹
    • Organizer
      第43回複素環化学討論会
    • Place of Presentation
      岐阜
    • Data Source
      KAKENHI-PROJECT-24590138
  • [Presentation] 強力なフコシダーゼ阻害活性を有するポリヒドロキシピペリジン誘導体の合成2013

    • Author(s)
      岡城 徹, 坂 知樹, 湊 大志郎, 杉本 健士, 松谷 裕二, 中川 進平, 山下 侑子, 加藤 敦, 足立 伊佐雄, 手塚 康弘, Peter G. Kirira, 尾野村 治, 豊岡尚樹
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-24590138
  • [Presentation] フコシダーゼ阻害が期待されるアミド型イミノ糖の合成および活性評価2013

    • Author(s)
      伊福 翔平・岡城 徹・中川 進平・加藤 敦・足立 伊佐雄・Peter G. Kirira・尾野村 治・豊岡 尚樹
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-24590138
  • [Presentation] 栄養飢餓耐性解除に基づく新規膵臓がん治療薬の開発研究2012

    • Author(s)
      谷口 瑛,工藤直紀,松谷裕二,杉本健士,友廣岳則,畑中保丸,川崎正志,Suresh Awale,李 峰,手塚康弘,門田重利,三好千香,江角浩安,豊岡尚樹
    • Organizer
      第42回複素環化学討論会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-22590098
  • [Presentation] Synthesis of Novel Iminosugar Derivatives with Inhibitory Effects on α-Fucosidase2012

    • Author(s)
      Toru Okaki, Tomoki Saka, Daishiro Minato, Kenji Sugimoto, Yuji Matsuya, Shinpei Nakagawa, Yukiko Yamashita, Atsushi Kato, Isao Adachi, Peter G. Kirira, Osamu Onomura, Naoki Toyooka
    • Organizer
      The 12th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-12)
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-24590138
  • [Presentation] 栄養飢餓耐性解除に基づく新規膵臓がん治療薬の開発研究2011

    • Author(s)
      谷口 瑛,工藤直紀,松谷裕二,杉本健士,川崎正志,Suresh Awale,手塚康弘,門田重利,三好千香,江角浩安,豊岡尚樹
    • Organizer
      平成23年度有機合成化学北陸セミナー
    • Place of Presentation
      福井県坂井市
    • Data Source
      KAKENHI-PROJECT-22590098
  • [Presentation] 梅洋産アルカロイド・Batzellaside類の合成研究2010

    • Author(s)
      関口真廷, 周徳軍, 松谷裕二, 豊岡尚樹
    • Organizer
      第36回反応と合成の進歩シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2010-11-01
    • Data Source
      KAKENHI-PROJECT-21590004
  • [Presentation] Synthetic Studies on Marine Alkaloid Batzellaside A, B and C2010

    • Author(s)
      関口真廷, 周徳軍, 松谷裕二, 豊岡尚樹
    • Organizer
      日本薬学会北陸支部第121回例会
    • Place of Presentation
      金沢
    • Year and Date
      2010-11-21
    • Data Source
      KAKENHI-PROJECT-21590004
  • [Presentation] 海洋産アルカロイドBatzellaside類の合成研究2009

    • Author(s)
      豊岡尚樹
    • Organizer
      平成21年度有機合成化学北陸セミナー
    • Place of Presentation
      富山
    • Year and Date
      2009-10-09
    • Data Source
      KAKENHI-PROJECT-21590004
  • [Presentation] ピロリチジン型毒ガエルアルカロイドの合成研究2008

    • Author(s)
      周徳軍, 豊岡尚樹, 根本英雄, 手塚康弘, 門田重利, H. Martin Garraffo, Thomas F. Spande, John W. Daly
    • Organizer
      第34回反応と合成の進歩シンポジウム
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Presentation] 毒ガエルアルカロイド179, 207Eの合成2008

    • Author(s)
      豊岡尚樹, 周徳軍, 古林創史, 恒枝宏史, 和田努, 酒井秀紀, 根本英雄, 笹岡利安, 手塚康弘, Subehan, 門田重利, H. Martin Garraffo, Thomas F. Spande, John W. Daly
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      Yokohama
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Presentation] アリから単離されたヒドロキシインドリチジンアルカロイドの合成2008

    • Author(s)
      豊岡尚樹, 周徳軍, 根本英雄, 山口薫, 恒枝宏史, 和田努, 笹岡利安, 手塚康弘, 門田重利, H. Martin Garraffo, Thomas F. Spande, John W. Daly
    • Organizer
      第38回複素環化学討論会
    • Place of Presentation
      Fukuyama
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Presentation] ピロリチジン型毒ガエルアルカロイドの合成研究2008

    • Author(s)
      周 徳軍, 豊岡尚樹, 根本英雄, 山口 薫, 手塚康弘, 門田重利, Garraffo, H. M., Spande, T. F., Daly, J. W.
    • Organizer
      第34回反応と合成の進歩シンポジウム
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Presentation] Monomorine I 両対掌体の短工程合成2008

    • Author(s)
      周 徳軍, 豊岡尚樹, 根本英雄
    • Organizer
      日本薬学会北陸支部第118回例会
    • Place of Presentation
      富山
    • Year and Date
      2008-07-05
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Presentation] アリから単離されたヒドロキシインドリチジンアルカロイドの合成2008

    • Author(s)
      豊岡尚樹, 周 徳軍, 根本英雄, 山口 薫, 恒枝宏史, 和田 努, 笹岡利安, 手塚康弘, Garraffo, H. M., Spande, T. F., Daly, J. W., Jones, T. H.
    • Organizer
      第38回複素環化学討論会
    • Place of Presentation
      福山
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Presentation] Synthesis of Proposed Structure of Poison-frog Alkaloids 207E and 179 and Their Inhibitory Effects on Nicotinic Acetylcholine Receptors2007

    • Author(s)
      Toyooka, N ; Zhou, D. ; Kobayashi, S. ; Tsuneki, H. ; Sasaoka, T. ; Nemoto, H. ; Garraffo, H. M. ; Spande, T. F. ; Daly, J. W.
    • Organizer
      the 19th French-Japanese Symposium on Medicinal and Fine Chemistry
    • Place of Presentation
      Toyama
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Presentation] Synthesis of Proposed Structure of Poison-frog Alkaloids207E and 179 and Their Inhibitory Effects on Nicotinic Acetylcholine Receptors2007

    • Author(s)
      Naoki TOYOOKA, Dejun ZHOU, Soushi KOBAYASHI, Hiroshi TSUNEKI, Toshiyasu SASAOKA, Hideo NBMOTO, H. Martin GARRAFFO, Thomas F. SPANDE and John W. DALY
    • Organizer
      The nineteenth French-Japanese Symposium on Medicinai and Fine Chemlstry (FJS 2007)
    • Place of Presentation
      富山
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Presentation] Synthetic Studies on Biologically Active Alkaloids2006

    • Author(s)
      Toyooka, N.
    • Organizer
      Xiamen University
    • Place of Presentation
      Xiamen
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Presentation] Synthetic Studies on Biologically Active Alkaloids2006

    • Author(s)
      Toyooka, N.
    • Organizer
      Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
    • Place of Presentation
      Shanghai
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Presentation] 毒ガエルアルカロイド233A, 251AA, 235Uのキラル合成2006

    • Author(s)
      周徳軍、豊岡尚樹、根本英雄、Garraffo, H.M. ; Spande, T.F. ; Daly, J.W.
    • Organizer
      日本薬学会北陸支部第114例会
    • Place of Presentation
      Kanazawa
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Presentation] 毒ガエルアルカロイドの合成とそのニコチン受容体抑制活性評価2006

    • Author(s)
      周徳軍、豊岡尚樹、恒枝宏史、古林創史、笹岡利安、根本英雄、Daly, J.W. ; Spande, T.F. ; Garraffo, H.M.
    • Organizer
      第32回反応と合成の進歩シンポジウム
    • Place of Presentation
      Hiroshima
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Presentation] Chiral Synthesis of 5, 8-Disubstituted Indolizidine Type Poison-frog Alkaloids2006

    • Author(s)
      Toyooka, N. ; Zhou, D. ; Nemoto, H. ; Garraffo, H.M. ; Spande, T.F. ; Daly, J W.
    • Organizer
      International Molecular Chirality Conference in Toyama
    • Place of Presentation
      Toyama
    • Data Source
      KAKENHI-PROJECT-17590004
  • [Presentation] 海洋産アルカロイド・Batzellaside類の合成研究

    • Author(s)
      関口真廷、周徳軍、松谷裕二、豊岡尚樹
    • Organizer
      第36回反応と合成の進歩シンポジウム
    • Data Source
      KAKENHI-PROJECT-21590004
  • [Presentation] Synthetic Studies on Marine Alkaloid Batzellaside A, B and C

    • Author(s)
      関口真廷、周徳軍、松谷裕二、豊岡尚樹
    • Organizer
      日本薬学会北陸支部第121回例会
    • Data Source
      KAKENHI-PROJECT-21590004
  • [Presentation] Aldo-keto reductase1C3(AKR1C3) 選択的阻害活性を有する baccharin非プレニル誘導体の合成

    • Author(s)
      遠藤 智史、胡 大イ、松永 俊之、大辻 陽子、Ossama EI-Kabbani、Mahmoud Kandeel、五十里 彰、原 明、北出 幸夫、豊岡 尚樹
    • Organizer
      第32回メディシナルシンポジウム(神戸)
    • Place of Presentation
      神戸
    • Year and Date
      2014-11-26 – 2014-11-28
    • Data Source
      KAKENHI-PROJECT-26460149
  • [Presentation] 海洋産アルカロイドBatzellaside類の合成研究

    • Author(s)
      豊岡尚樹、関口真廷、周徳軍,松谷裕二
    • Organizer
      平成21年度有機合成化学北陸セミナー
    • Data Source
      KAKENHI-PROJECT-21590004
  • [Presentation] セリンラセマーゼ新規阻害剤の開発

    • Author(s)
      和田亮吾, Li Jie, 合田浩昭, 広野修一, 水口峰之, 豊岡尚樹, 森寿
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-25293059
  • 1.  GOUDA HIROAKI (60276160)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 4 results
  • 2.  SASAOKA Toshiyasu (00272906)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 15 results
  • 3.  KATO Atsushi (60303236)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
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    # of Collaborated Products: 5 results
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    # of Collaborated Products: 17 results
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    # of Collaborated Products: 3 results
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  • 14.  NEMOTO Hideo (60006351)
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  • 15.  TAKASAKI ICHIRO (00397176)
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    # of Collaborated Products: 1 results
  • 16.  KURIHARA TAKASHI (60282745)
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    # of Collaborated Products: 5 results
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  • 20.  赤沼 伸乙 (30467089)
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  • 21.  TSUJII Kenichiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  HONMA Azusa
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  KUWAZONO Takashi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  MANO Yousuke
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  TAKAHASHI Ryohei
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  YOSHIDA Tetsuro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  TAKAYAMA Yusuke
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  SUZUKI Kazunari
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  KIMURA Yuusuke
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  ASAI Ayana
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  WADA Tutomu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  UMEDA Tomonobu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  広野 修一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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