Ohyama Manabu 大山学

… Alternative Names

大山学オオヤママナブ

OHYAMA Manabu 大山学

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Researcher Number	10255424
Other IDs
Affiliation (Current)	2025: 杏林大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2025: 杏林大学, 医学部, 教授 2022 – 2023: 杏林大学, 医学部, 教授 2015 – 2019: 杏林大学, 医学部, 教授 2014: 慶應義塾大学, 医学部, 准教授 2010 – 2013: 慶應義塾大学, 医学部, 講師 … More 2008 – 2010: 慶応義塾大学, 医学研究科, 講師 2007 – 2008: Keio University, 医学部, 講師 2006: 慶應義塾大学, 医学部, 助手 1999 – 2001: 慶應義塾大学, 医学部, 助手 2000: 慶應大, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Dermatology / Basic Section 53050:Dermatology-related / Dermatology Except Principal Investigator Dermatology / Dermatology / Veterinary medical science / Clinical veterinary science
Keywords	Principal Investigator 毛包 / 分化誘導 / ヒトiPS細胞 / 付属器 / 再生医学 / ケラチノサイト / 毛乳頭細胞 / 毛包モデル / JAK阻害薬 / 疾患モデル … More / ヒト培養皮膚 / 皮膚疾患 / 組織再生 / 汗腺 / 立体培養 / 皮膚付属器 / iPS細胞 / 発生・分化 / ヒト付属器再生 / 皮膚再生学 / 付属器再生 / ヒト皮膚再生 / スクリーニング / 共培養 / 細胞・組織 / ヒト毛包再生 / 上皮―間葉系相互作用 / 上皮ー間葉系相互作用 / 毛包再生 / 幹細胞 / 組織再構成 / 毛乳頭 / バルジ / 皮膚幹細胞 / 毛嚢 / 皮膚生理学 … More Except Principal Investigator 自己免疫 / Model mouse / Autoimmune / ノックアウトマウス / モデルマウス / 創傷治癒 / 毛包 / 幹細胞 / 天疱瘡 / 自己抗体 / WNTシグナル / FGF / 毛乳頭細胞 / 線維芽細胞 / 毛包新生 / 毛包再生 / desmoglein / pemphigus / knockout mouse / bullous disease / epitope / Autoantibody / デスモグレイン / 水疱症 / エピトープ / CD40 ligand / Skin graft / Knockout mouse / Immune response / Inherited disease / Gene therapy / 経鼻免疫 / 経口免疫 / 免疫寛容 / 遺伝性皮膚疾患 / CD40リガンド / 皮膚移植 / 免疫宣容 / 遺伝皮膚疾患 / 遺伝子治療 / 神経堤細胞 / 皮膚腫瘍 / コンディショナルノックアウトマウス / ネスチン / 経皮免疫 / 抗原感作 / 皮膚バリア解析 / 角質 / アトピー性皮膚炎 / タイトジャンクション / 皮膚バリア機構 / ランゲルハンス細胞 / 角質バリア / タイトジャンクションバリア / 皮膚バリア / 皮膚 / 犬 / 重症度 / BIAcore / バイオセンサー / 反応速度 / 自己抗原 Less

Assessment of influence of Janus kinase inhibitors on hair follicles using human hair regeneration modelPrincipal Investigator
- Principal Investigator
  
  大山学
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Kyorin University
Attempt to reproduce pathophysiology of skin diseases by use of human three-dimensional skin equivalent with regenerated skin appendage structuresPrincipal Investigator
- Principal Investigator
  
  大山学
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Kyorin University
Attempt to regenerate skin appendages using reconstituted embryonal-like skin equivalent using human induced pluripotent stem cellsPrincipal Investigator
- Principal Investigator
  
  Ohyama Manabu
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Kyorin University
Attempt to establish screening system for drug to treat alopecia using human iPS cellsPrincipal Investigator
- Principal Investigator
  
  Manabu Ohyama
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  Kyorin University
Development of folliclogenetic tecnique utilizing mesenchymal cells capable of controlling microenvironment
- Principal Investigator
  
  Kinoshita Misaki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Kyorin University
Attempt to regenerate hair follicles using human iPS cell-derived epithelial and mesenchymal cells optimized for trichogenicityPrincipal Investigator
- Principal Investigator
  
  Ohyama Manabu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Kyorin University
  Keio University
Investigation of unknown transdifferentiation mechanisms of cutaneous epithelial tumor and related genes
- Principal Investigator
  
  NISHIFUJI Koji
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Veterinary medical science
- Research Institution
  Tokyo University of Agriculture and Technology
Analysis of the dynamic skin immune and physical barrier system by tight junctions and Langerhans cells
- Principal Investigator
  
  KUBO Akiharu
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
Identification of canine hair follicle stem cells, reconstruction Of hair follicle and its application to wound healing
- Principal Investigator
  
  IWASAKI Toshiroh
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Clinical veterinary science
- Research Institution
  Tokyo University of Agriculture and Technology
Experimental regeneration of human hair follicles using CD200 positive bulge cellsPrincipal Investigator
- Principal Investigator
  
  OHYAMA Manabu
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
天疱瘡自己抗体の3次元エピトープの解析Principal Investigator
- Principal Investigator
  
  大山学
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  Keio University
Basic studies for development of disease-specific therapeutic strategies against autoimmune diseases
- Principal Investigator
  
  NISHIKAWA Takeji
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
抗原抗体反応速度論的解析による自己抗体病原性強度の新しい指標の開発
- Principal Investigator
  
  MASAYUKI Amagai
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  Keio University
Development of immune supression against gene product in gene therapy
- Principal Investigator
  
  AMAGAI Masayuki
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Keio University

[Book] Springer Series Advances in Stem Cell Biology “Induced Pluripotent Stem Cells; Novel Concepts” Chapter: Strategies to utilize iPS cells for hair follicle regeneration and the treatment of hair loss disorders2020
- Author(s)
  Manabu Ohyama (Alex Birbrair ed.)
- Publisher
  Elsevier (San Diego)
- ISBN
  9780128222287
- Data Source
  KAKENHI-PROJECT-16H05370
[Book] 毛髪科学の新展開（第５章：脱毛症の病態から考える毛包再生医療の適応と課題）2019
- Author(s)
  大山　学　（監修：岩渕徳郎）
- Total Pages
  283
- Publisher
  シーエムシー出版
- ISBN
  9784781314341
- Data Source
  KAKENHI-PROJECT-16H05370
[Journal Article] Increase in CD8+ Effector Memory T Cells Re-Expressing CD45RA Correlates with Intractability of Severe Alopecia Areata2024
- Author(s)
  Ryo Takahashi, Misaki Kinoshita-Ise, Yoshimi Yamazaki, Masahiro Fukuyama, Manabu Ohyama
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: S0022-202X(24)00025-3 Issue: 7 Pages: 1654-1657.e7
- DOI
  10.1016/j.jid.2024.01.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08438, KAKENHI-PROJECT-20K17328
[Journal Article] Use of human intra-tissue stem/progenitor cells and induced pluripotent stem cells for hair follicle regeneration2019
- Author(s)
  Ohyama Manabu
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 39 Issue: 1 Pages: 4-4
- DOI
  10.1186/s41232-019-0093-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05370
[Journal Article] Induction of hair follicle dermal papilla cell properties in human induced pluripotent stem cell-derived multipotent LNGFR(+)THY-1(+) mesenchymal cells2017
- Author(s)
  Ophelia Veraitch, Yo Mabuchi, Yumi Matsuzaki, Takashi Sasaki, Hironobu Okuno, Aki Tsukashima, Masayuki Amagai, Hideyuki Okano, Manabu Ohyama
- Journal Title
  
  Scientific Reports
  
  Volume: 21 Issue: 1 Pages: 42777-42777
- DOI
  10.1038/srep42777
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K15421, KAKENHI-PROJECT-15K06853
[Journal Article] LNGFR+THY-1+ Human Pluripotent Stem Cell-derived Neural Crest-Like Cells Have the Potential to Develop Into Mesenchymal Stem Cells2016
- Author(s)
  Takehito Ouchi, Satoru Morikawa, Shinsuke Shibata, Kimiko Fukuda, Hironobu Okuno, Takumi Fujimura, Tatsuo Kuroda, Manabu Ohyama, Wado Akamatsu, Taneaki Nakagawa, Hideyuki Okano
- Journal Title
  
  Differentiation
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293246
[Journal Article] iPS細胞の毛包への誘導2015
- Author(s)
  大山　学
- Journal Title
  
  日本臨牀増刊号「再生医療」
  
  Volume: 73 Pages: 193-198
- Data Source
  KAKENHI-PROJECT-25293246
[Journal Article] Promise of human induced pluripotent stem cells in skin regeneration and investigation.2014
- Author(s)
  Ohyama M, Okano H
- Journal Title
  
  J Invest Dermatol
  
  Volume: 134 Issue: 3 Pages: 605-609
- DOI
  10.1038/jid.2013.376
- Data Source
  KAKENHI-PROJECT-25293246
[Journal Article] Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin.2012
- Author(s)
  Keisuke Nagao
- Journal Title
  
  Nature Immunology
  
  Volume: 13(8) Issue: 8 Pages: 744-752
- DOI
  10.1038/ni.2353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J08120, KAKENHI-PROJECT-21229014, KAKENHI-PROJECT-22249044, KAKENHI-PROJECT-22390095, KAKENHI-PROJECT-23790432, KAKENHI-PROJECT-24659216, KAKENHI-PROJECT-24659373, KAKENHI-PUBLICLY-23118526
[Journal Article] Molecular biological and immunohistopathological characterization of canine dermal papilla cells and the evaluation of cutaneous conditions2011
- Author(s)
  Kobayashi T, Iwasaki T, Ohyama T, et al.
- Journal Title
  
  Veterinary Dermatology
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380171
[Journal Article] Molecular biological and immunohistological characterization of canine dermal papilla cells and the evaluation of cutaneous conditions.2011
- Author(s)
  Kobayashi T, Fujisawa A, Amagai A, Iwasaki T, Ohyama M
- Journal Title
  
  Veterinary Dermatology in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380171
[Journal Article] Canine follicle stem cell candidates reside in the bulge and share characteristic features with human bulge cells.2010
- Author(s)
  Kobayashi T, Iwasaki T, Amagai M, Ohyama M
- Journal Title
  
  Journal of Investigative Dermatology 130
  
  Pages: 1988-1995
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380171
[Journal Article] Canine follicle stem cell candidates reside in the bulge and share chars cteristic features with human bulge cells2010
- Author(s)
  Kobayashi T, Iwasaki T, Ohyama, et al.
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 130 Pages: 1988-1995
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380171
[Journal Article] Canine hair-follicle keratinocytes enriched with bulge cells have the highly proliferative characteristic of stem cells.2009
- Author(s)
  Kobayashi T, Shimizu A, Nishifuji K, Amagai M, Iwasaki T, Ohyama M
- Journal Title
  
  Veterinary Dermatology 20
  
  Pages: 338-346
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380171
[Journal Article] Sparing of the bulge area could preserve intact lower portion of hair follicles in a case of tufted folliculitis2009
- Author(s)
  Miura M, Dekio I, Yamasaki Y, Ohyama M
- Journal Title
  
  J Eur Acad Dermatol Venereol 23
  
  Pages: 87-89
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390315
[Journal Article] Sparing of the bulge area could preserve intact lower portion of hair follicles in a case of tufted folliculitis2009
- Author(s)
  Miura M, Dekio I, Yamasaki Y, Ohyama M.
- Journal Title
  
  J Eur Acad Dermatol Venereol 23(1)
  
  Pages: 87-89
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390315
[Journal Article] 皮膚幹細胞の新知見2009
- Author(s)
  大山学
- Journal Title
  
  日本皮膚科学会雑誌 (印刷中)
- NAID
  10028279218
- Data Source
  KAKENHI-PROJECT-18390315
[Journal Article] 毛包幹細胞・毛包再生の最前線2008
- Author(s)
  大山学
- Journal Title
  
  Monthly Book Derma 145
  
  Pages: 7-13
- Data Source
  KAKENHI-PROJECT-18390315
[Journal Article] Gene ontology analysis of human hair follicle bulge molecular signature2007
- Author(s)
  Ohyama M, Vogel JC, Amagai M.
- Journal Title
  
  J Dermatol Sci 45
  
  Pages: 147-150
- NAID
  10024115400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390315
[Journal Article] ヒト毛嚢再生に向けてのアプローチ2007
- Author(s)
  大山学
- Journal Title
  
  医学のあゆみ 223(11,12)
  
  Pages: 922-923
- Data Source
  KAKENHI-PROJECT-18390315
[Journal Article] Advances in the study of stem-cell-enriched hair follicle bulge cells: A review featuring characterization and isolation of human bulge cells.2007
- Author(s)
  Ohyama M
- Journal Title
  
  Dermaotlogy 214(4)
  
  Pages: 342-351
- Data Source
  KAKENHI-PROJECT-18390315
[Journal Article] Advances in the study of stem-cell-enriched hair follicle bulge cells : A review featuring characterization and isolation of human bulge cells2007
- Author(s)
  Ohyama M
- Journal Title
  
  Dermaotlogy 214(4)
  
  Pages: 342-351
- Data Source
  KAKENHI-PROJECT-18390315
[Journal Article] Gene ontology analysis of human hair follicle bulge molecular signature.2007
- Author(s)
  Ohyama M, Vogel JC, Amagai M
- Journal Title
  
  Journal of Dermatological Science 45(2)
  
  Pages: 147-150
- NAID
  10024115400
- Data Source
  KAKENHI-PROJECT-18390315
[Journal Article] 12007
- Author(s)
  大山学
- Journal Title
  
  日本皮膚科学会雑誌 117(13)
  
  Pages: 2415-2417
- Data Source
  KAKENHI-PROJECT-18390315
[Journal Article] Hair follicle bulge : A fascinating reservoir of epithelial stem cells2007
- Author(s)
  Ohyama M
- Journal Title
  
  J Dermatol Sci 46(2)
  
  Pages: 81-89
- NAID
  10024115945
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390315
[Journal Article] The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice
- Author(s)
  Kiso T, Tanaka S, Saba R, Matsuda S, Shimizu A, Ohyama M, Okano HJ, Shirotori T, Okano H, Saga Y.
- Journal Title
  
  Proc Natl Acad Sci USA (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390315
[Journal Article] The Mesenchymal component of hair follicle neogenesis : Background, methods and molecular characterization
- Author(s)
  Ohyama M, Zheng Y, Paus R, Stenn, KS
- Journal Title
  
  Exp Dermatol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390315
[Journal Article] Hair follicle bulge : A fascinating reservoir of epithelial stem cells.
- Author(s)
  Ohyama M
- Journal Title
  
  Journal of Dermatological Science In press
- NAID
  10024115945
- Data Source
  KAKENHI-PROJECT-18390315
[Patent] 特許権2008
- Inventor(s)
  大山学, 天谷雅行
- Industrial Property Rights Holder
  慶應義塾
- Filing Date
  2008-08-22
- Data Source
  KAKENHI-PROJECT-18390315
[Patent] 特許権2008
- Inventor(s)
  大山学、天谷雅行
- Industrial Property Rights Holder
  学校法人慶應義塾
- Filing Date
  2008-08-22
- Data Source
  KAKENHI-PROJECT-18390315
[Presentation] WNT・FGFシグナル活性化因子と3次元細胞凝集を用いたヒト毛乳頭細胞の特性維持法確立の試み2024
- Author(s)
  大山　学、早川怜那、塚島明希、山﨑好美、君嶋桃子、福山雅大
- Organizer
  第23回日本再生医療学会
- Data Source
  KAKENHI-PROJECT-22K08438
[Presentation] 皮膚・付属器再生におけるiPS細胞の有用性についてー組織幹細胞・前駆細胞との比較を含めて2020
- Author(s)
  大山　学
- Organizer
  第19回日本再生医療学会（本来3/12-14開催を延期5/18-29Web開催）
- Invited
- Data Source
  KAKENHI-PROJECT-16H05370
[Presentation] ヒトiPS細胞由来毛乳頭様構造体を用いたin vitroヒト毛包構造再生の試み2020
- Author(s)
  福山雅大、塚島明希、君嶋桃子、山﨑好美、岡野栄之、大山　学
- Organizer
  第19回日本再生医療学会（本来3/12-14開催を延期5/18-29Web開催）
- Data Source
  KAKENHI-PROJECT-16H05370
[Presentation] Attempts to regenerate human hair follicle structure in vitro by three-dimentionally assembling tissue- and iPS cell-derived cell composites.2019
- Author(s)
  Fukuyama M, Tsukashima A, Kimishima M, Yamazaki Y, Ohyama M.
- Organizer
  The 44th Annual Meeting of the Japanese Society for Investigative Dermatology
- Data Source
  KAKENHI-PROJECT-16H05370
[Presentation] ヒト3次元培養皮膚を用いた毛器官発生シグナル因子が上皮ー間葉系相互作用に与える影響の検討2019
- Author(s)
  福山雅大、塚島明希、君嶋桃子、山崎好美、大山　学
- Organizer
  第18回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-16H05370
[Presentation] 幹細胞・前駆細胞を用いたヒト毛包再生戦略2019
- Author(s)
  大山　学
- Organizer
  第118回日本皮膚科学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05370
[Presentation] 毛包幹細胞の基礎と臨床2018
- Author(s)
  大山　学
- Organizer
  第117回日本皮膚科学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05370
[Presentation] 皮膚・付属器の幹細胞と再生の現状2018
- Author(s)
  大山　学
- Organizer
  第39回日本炎症・再生医学会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05370
[Presentation] 安定した３次元培養皮膚作成のためのフィーダーフリー培養ヒトiPS細胞由来細胞調整法の検討2018
- Author(s)
  福山雅大、塚島明希、君嶋桃子、山﨑好美、大山　学
- Organizer
  第17回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-16H05370
[Presentation] Human scalp-derived fibroblasts alter FGF expression profile upon WNT activation: implication of their role to provide folliculogenetic microenvironment2017
- Author(s)
  Misaki Kinoshita-Ise, Aki Tsukashima, Tomonari Kinoshita, Yoshimi Yamazaki, Manabu Ohyama
- Organizer
  76th SID annual meeting
- Place of Presentation
  Portland (USA)
- Year and Date
  2017-04-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19703
[Presentation] ヒト毛包再生に向けた上皮ー間葉系相互作用を可能にする細胞の作成-Dermal papilla細胞を中心に－2017
- Author(s)
  大山　学
- Organizer
  第38回日本炎症・再生医学会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05370
[Presentation] Attempt to establish a hair follicile co-culture model using feeder-free human iPS cells2017
- Author(s)
  Manabu Ohyama, Aki Tsukashima, Momoko Kimishima, Yoshimi Yamazaki, Hideyuki Okano
- Organizer
  The 27th Annual Meeting of the Korean Society for Investigative Dermatology
- Place of Presentation
  韓国、ソウル
- Year and Date
  2017-03-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15421
[Presentation] ヒト線維芽細胞におけるWNTシグナル活性化時のFGF発現プロファイル変化とその毛包再生促進効果の検討2017
- Author(s)
  木下　美咲、塚島　明希、木下　智成、山崎　好美、大山　学
- Organizer
  第16回日本再生医療学会
- Place of Presentation
  仙台国際センター（宮城県・仙台市）
- Year and Date
  2017-03-09
- Data Source
  KAKENHI-PROJECT-15K19703
[Presentation] ヒトiPS細胞を用いた毛包再生の試み2016
- Author(s)
  大山　学
- Organizer
  第79回日本皮膚科学会東京・東部支部合同学術大会
- Place of Presentation
  東京
- Year and Date
  2016-02-20
- Invited
- Data Source
  KAKENHI-PROJECT-15K15421
[Presentation] Current strategy of using stem/ progenitor cells for the treatment of hair diseases2016
- Author(s)
  Manabu Ohyama
- Organizer
  18th Hamchun Dermatology Symposium
- Place of Presentation
  ソウル、韓国
- Year and Date
  2016-06-11
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05370
[Presentation] ヒトiPS細胞を用いた毛包再生の試み2016
- Author(s)
  大山　学
- Organizer
  第79回日本皮膚科学会東京・東部支部合同学術大会
- Place of Presentation
  東京
- Year and Date
  2016-02-20
- Invited
- Data Source
  KAKENHI-PROJECT-25293246
[Presentation] Current strategy to enhance epithelial-mesenchymal interactions for human hair follicle bioengineering2015
- Author(s)
  Manabu Ohyama
- Organizer
  World Congress of Dermatology 2015
- Place of Presentation
  バンクーバー、カナダ
- Year and Date
  2015-06-09
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293246
[Presentation] Recent progress on hair bioengineering2015
- Author(s)
  Manabu Ohyama
- Organizer
  World Congress of Dermatology 2015
- Place of Presentation
  バンクーバー、カナダ
- Year and Date
  2015-06-10
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293246
[Presentation] Cunrrent strategies for human hair follicle regeneration using stem or progenitor cells2015
- Author(s)
  Manabu Ohyama
- Organizer
  World Congress of Dermatology 2015
- Place of Presentation
  バンクーバー、カナダ
- Year and Date
  2015-06-09
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15421
[Presentation] Investigation of the tight junction barrier in hair follicles and sebaceous glands2011
- Author(s)
  Kubo A, Yokouchi M, Atsugi T, Ohyama M, Amagai M
- Organizer
  The 36th Annual Meeting of the Japanese Society for Investigative Dermatology
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-22249044
[Presentation] Human epidermal tight junctions are functional and allow penetration of activated Langerhans cell dendrites2011
- Author(s)
  Yoshida K, Kubo A, Yokouchi M, Ishii K, Kawasaki H, Ebihara T, Ohyama M, Nagao K, Amagai M
- Organizer
  71th Annual Meeting Society for Investigative Dermatology
- Place of Presentation
  Phoenix, Arizona
- Year and Date
  2011-05-05
- Data Source
  KAKENHI-PROJECT-22249044
[Presentation] Recent advances in canine hair follicle stem cell biology2011
- Author(s)
  小林哲郎, 岩崎利郎, 大山学
- Organizer
  2011 Annual Meeting of Australian College of Veterinary Sciences.
- Place of Presentation
  Gold Coast, Australia
- Data Source
  KAKENHI-PROJECT-20380171
[Presentation] 犬の毛包幹細胞の同定および生物学的特徴の解析2010
- Author(s)
  小林哲郎、西藤公司、天谷雅之、岩崎利郎、大山学
- Organizer
  第149回日本獣医学会学術集会シンポジウム:再生医療の最前線～獣医臨床応用に向けた課題
- Place of Presentation
  東京
- Year and Date
  2010-03-27
- Data Source
  KAKENHI-PROJECT-20380171
[Presentation] Canine bulge cells share intrinsic properties with human bulge cells and provide a novel model for human hair follicles stem cell research.2010
- Author(s)
  Kobayashi T, Iwasaki T, Amagai M, Ohyama M
- Organizer
  6^<th> World Congress for Hair Research
- Place of Presentation
  Cairns, Australis
- Data Source
  KAKENHI-PROJECT-20380171
[Presentation] Canine bulge cells share intrinsic proterties with human bulge cells abd provide a novel model for human hair follicle stem cell research2010
- Author(s)
  Kobayashi T, Iwasaki T, Amagai M, Ohyama M
- Organizer
  The 6^<th> World Congress of Hair Research
- Place of Presentation
  Cairns, Australia
- Data Source
  KAKENHI-PROJECT-20380171
[Presentation] 犬の毛包幹細胞の同定と創傷治癒への応用について2010
- Author(s)
  小林哲郎、岩崎利郎、大山学, ほか
- Organizer
  第149回日本獣医学会
- Place of Presentation
  日本獣医畜産大学、東京
- Year and Date
  2010-03-27
- Data Source
  KAKENHI-PROJECT-20380171
[Presentation] 新鮮分離ヒト毛乳頭の分子署名の解明-ヒト毛嚢再生に向けてのアプローチ-2009
- Author(s)
  大山学, 小林哲郎, 清水篤, 天谷雅行
- Organizer
  第8回日本再生医療学会
- Place of Presentation
  東京
- Year and Date
  2009-03-06
- Data Source
  KAKENHI-PROJECT-18390315
[Presentation] イヌの毛包幹細胞の同定および生物学的特徴の解析2009
- Author(s)
  小林哲郎、岩崎利郎、大山学, ほか
- Organizer
  第148回日本獣医学会
- Place of Presentation
  とりぎん文化会館、鳥取
- Year and Date
  2009-09-26
- Data Source
  KAKENHI-PROJECT-20380171
[Presentation] An attempt to regenerate human dermal papilla with hair inductive capacity using 3D culture. system2009
- Author(s)
  Ohyama, M
- Organizer
  Forefront of the regenerative medicine, Symposium 2009
- Place of Presentation
  東京
- Year and Date
  2009-01-23
- Data Source
  KAKENHI-PROJECT-18390315
[Presentation] 犬の毛包幹細胞の同定および生物学的特徴の解析2009
- Author(s)
  小林哲郎、岩崎利郎、西藤公司、大山学
- Organizer
  第148回日本獣医学会学術集会
- Place of Presentation
  鳥取
- Data Source
  KAKENHI-PROJECT-20380171
[Presentation] Microarray analysis of freshly-microdissected intact human dermal papilla identified upregulation of genes that could contribute to biological distinctiveness.2008
- Author(s)
  Ohyama M, Shimizu A, Kobayashi T Amagai M
- Organizer
  International Investigative Dermatology 2008
- Place of Presentation
  京都
- Year and Date
  2008-05-16
- Data Source
  KAKENHI-PROJECT-18390315
[Presentation] 犬毛包はヒト毛包幹細胞研究に有用である-バルジ細胞の類似性を中心に-2008
- Author(s)
  小林哲郎、岩崎利郎、天谷雅之、大山学
- Organizer
  第15回毛髪科学研究会
- Place of Presentation
  福岡
- Year and Date
  2008-11-09
- Data Source
  KAKENHI-PROJECT-20380171
[Presentation] Dissecting out molecular signatures of hair follicle key components : Implication of human hair follicle regeneration2008
- Author(s)
  Ohyama M
- Organizer
  Satellite Symposium on Hair Research, International Investigative Dermatology 2008
- Place of Presentation
  京都
- Year and Date
  2008-05-13
- Data Source
  KAKENHI-PROJECT-18390315
[Presentation] 遺伝子発現プロファイルとコロニー形成能からみたヒト毛包バルジ細胞の幹細胞としての特性2008
- Author(s)
  大山学
- Organizer
  第7回日本再生医療学会総会シンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2008-03-13
- Data Source
  KAKENHI-PROJECT-18390315
[Presentation] Identification and isolation of highly proliferative canine hair follicle bulge cells : promising candidate for stem cells.2008
- Author(s)
  Kobayashi T, Nishifuji K, Iwasaki T, Amagai M, Ohyama M
- Organizer
  The 6^<th> World Congress of Veterinary Dermatology
- Place of Presentation
  Hong Kong
- Data Source
  KAKENHI-PROJECT-20380171
[Presentation] Identification and isolation of highly proliferative canine hair follicle bulge cells, promising candidates for stem cells.2008
- Author(s)
  Kobayashi T, Shimizu A, Nishifuji K, Amagai M, Iwasaki T Ohyama M
- Organizer
  World Congress of Veterinary Dermatology 2008
- Place of Presentation
  香港、中国
- Year and Date
  2008-11-20
- Data Source
  KAKENHI-PROJECT-18390315
[Presentation] 犬毛包はヒト毛包幹細胞研究に有用である-バルジ細胞の類似性を中心に-2008
- Author(s)
  小林哲郎, 岩崎利郎, 天谷雅行, 大山学
- Organizer
  第15回毛髪利学研究会
- Place of Presentation
  福岡
- Year and Date
  2008-11-29
- Data Source
  KAKENHI-PROJECT-20380171
[Presentation] Identification of human bulge cell counterpart in canine hair follicles : A valuable model for stem cell investigation.2008
- Author(s)
  Kobayashi T, Shimizu A, Amagai M, Iwasaki T, Ohyama M
- Organizer
  International Investigative Dermatology 2008
- Place of Presentation
  京都
- Year and Date
  2008-05-17
- Data Source
  KAKENHI-PROJECT-18390315
[Presentation] ヒト毛嚢幹細胞研究のマテリアルとしてのイヌ毛嚢の有用性の検討2008
- Author(s)
  大山学, 小林哲郎, 岩崎利郎, 天谷雅行
- Organizer
  第15回分子皮膚科学フォーラム
- Place of Presentation
  京都
- Year and Date
  2008-11-14
- Data Source
  KAKENHI-PROJECT-18390315
[Presentation] イヌ毛包はヒト毛包幹細胞研究に有用である-バルジ細胞の類似性を中心に-2008
- Author(s)
  小林哲郎, 岩崎利郎, 天谷雅行, 大山学
- Organizer
  第15回毛髪科学研究会
- Place of Presentation
  福岡
- Year and Date
  2008-11-29
- Data Source
  KAKENHI-PROJECT-18390315
[Presentation] Use of canine hair follicle epithelial hair follicle stem cells for the exploration of novel regenerative medicine approaches2008
- Author(s)
  Ohyama, M
- Organizer
  BCRT/BMBF Workshop, "Exploitation of hair follicle stem cells in skin defect healing"
- Place of Presentation
  Berlin, Germany
- Year and Date
  2008-06-19
- Data Source
  KAKENHI-PROJECT-18390315
[Presentation] Identification of human bulge cell counterpart in canine hair follicles : A valuable material for stem cell investigation2008
- Author(s)
  Kobayashi T, Iwasaki T, Nishifuji K, Amagai M, Ohyama M
- Organizer
  International Investigative Dermatology Meeting
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-20380171
[Presentation] Identification of human bulge cell counterpart in canine hair follicles : A valuable model for stem cell in vesitgation2008
- Author(s)
  Kobayashi T, Shimizu A, Amagai M, Iwasaki T, Ohyama M.
- Organizer
  International Investigative Dermatology 2008
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2008-05-17
- Data Source
  KAKENHI-PROJECT-18390315
[Presentation] レーザーキャプチャーマイクロダイセクションを用いたヒト毛嚢バルジ細胞の分子署名の解明と細胞表面マーカーの同定2008
- Author(s)
  大山学
- Organizer
  日本顕微鏡学会第52回シンポジウム
- Place of Presentation
  千葉
- Year and Date
  2008-10-18
- Data Source
  KAKENHI-PROJECT-18390315
[Presentation] Microarray analysis of freshly-microdissected intact human dermal papilla identified upregulation of genes that could contribute to biological distinctiveness2008
- Author(s)
  Ohyama M, Shimizu A, Kobayashi T and Amagai M.
- Organizer
  International Investigative Deramtology 2008
- Place of Presentation
  Kyoto Japan
- Year and Date
  2008-05-16
- Data Source
  KAKENHI-PROJECT-18390315
[Presentation] "Dissecting out molecular signatures of hair follicle key components : Implication of human hair follicle regeneration" Satellite Symposium on Hair Research2008
- Author(s)
  Ohyama M.
- Organizer
  International Investigative Dermatology 2008
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2008-05-13
- Data Source
  KAKENHI-PROJECT-18390315
[Presentation] Use of canine hair follicle epithelial hair follicle stem cellsfor the exploration of novel regenerative medicine approaches2008
- Author(s)
  Ohyama M
- Organizer
  BCRT/BMBF Workshop, “Exploitation of hair follicle stem cells in skin defect healing"
- Place of Presentation
  ベルリン、ドイツ
- Year and Date
  2008-06-19
- Data Source
  KAKENHI-PROJECT-18390315
[Presentation] ヒト毛嚢バルジは幹細胞のニッシェである-Gene Ontoogyによるマイクロアレイデータのバイオインフォーマティックス解析-2007
- Author(s)
  大山学, 他2名
- Organizer
  日本研究皮膚科学会第31回年次学術大会
- Place of Presentation
  東京
- Year and Date
  2007-08-03
- Data Source
  KAKENHI-PROJECT-18390315
[Presentation] ケラチノサイトの幹細胞2007
- Author(s)
  大山学
- Organizer
  第106回日本皮膚科学会総会
- Place of Presentation
  横浜
- Year and Date
  2007-04-22
- Data Source
  KAKENHI-PROJECT-18390315
[Presentation] ヒト毛乳頭のmolecular signatureの解析-毛乳頭細胞の何が特別なのか?-2007
- Author(s)
  大山学、清水篤、天谷雅行
- Organizer
  第14回分子皮膚科学フォーラム
- Place of Presentation
  松山
- Year and Date
  2007-09-15
- Data Source
  KAKENHI-PROJECT-18390315
[Presentation] ヒト毛乳頭のmolecular signatureの解析-毛乳頭細胞の何が特別なのか2007
- Author(s)
  大山学, 他2名
- Organizer
  日本研究皮膚科学会第31回年次学術大会
- Place of Presentation
  松山
- Year and Date
  2007-09-15
- Data Source
  KAKENHI-PROJECT-18390315
[Presentation] ヒトiPS細胞由来LNGFR(+)THY-1(+) 間葉系幹細胞を用いた毛誘導能をもつ細胞の作成
- Author(s)
  大山　学、Ophelia Veraitch、馬渕　洋、松崎有未、佐々木貴史、塚島明希、天谷雅行、岡野栄之
- Organizer
  第14回日本再生医療学会
- Place of Presentation
  パシフィコ横浜（神奈川県、横浜市）
- Year and Date
  2015-03-19 – 2015-03-21
- Data Source
  KAKENHI-PROJECT-25293246
[Presentation] Promise of human iPS cells for hair follicle regeneration
- Author(s)
  Manabu Ohyama
- Organizer
  8th World Congress of Hair Research
- Place of Presentation
  済州島（韓国）
- Year and Date
  2014-05-14 – 2014-05-17
- Invited
- Data Source
  KAKENHI-PROJECT-25293246
[Presentation] Advantages of using human iPS cells for hair follicle bioengineering
- Author(s)
  Manabu Ohyama
- Organizer
  British Society for Investigative Dermatology Meeting 2014
- Place of Presentation
  ニューキャッスル（イギリス）
- Year and Date
  2014-04-07 – 2014-04-09
- Invited
- Data Source
  KAKENHI-PROJECT-25293246
[Presentation] Use of human induced pluripotent stem cell-derived CD271+CD90+ mesenchymal stem cells for the generation of hair inductive dermal cells
- Author(s)
  Ophelia Veraitch, Yo Mabuchi, Yumi Matsuzaki, Takashi Sasaki, Aki Tsukashima, Masayuki Amagai, Hideyuki Okano, Manabu Ohyama
- Organizer
  The 39th Annual Meeting of the Japanese Society for Investigative Dermatology
- Place of Presentation
  ホテル阪急エキスポパーク（大阪府、吹田市）
- Year and Date
  2014-12-12 – 2014-12-14
- Data Source
  KAKENHI-PROJECT-25293246
[Presentation] Current strategy to enhance epithelial-mesenchymal interactions for human hair follicle bioengineering
- Author(s)
  Manabu Ohyama
- Organizer
  8th World Congress of Hair Research
- Place of Presentation
  済州島（韓国）
- Year and Date
  2014-05-14 – 2014-05-17
- Invited
- Data Source
  KAKENHI-PROJECT-25293246
[Presentation] Induction of dermal papilla properties in highly potent CD271+CD90+mesenchymal stem cells generated from human-induced pluripotent stem cells
- Author(s)
  Ophelia Veraitch, Yo Mabuchi, Yumi Matsuzaki, Masayuki Amagai, Hideyuki Okano, Manabu Ohyama
- Organizer
  British Society for Investigative Dermatology Meeting 2014
- Place of Presentation
  ニューキャッスル（イギリス）
- Year and Date
  2014-04-07 – 2014-04-09
- Data Source
  KAKENHI-PROJECT-25293246

1. MASAYUKI Amagai (90212563)

# of Collaborated Projects: 6 results

# of Collaborated Products: 16 results
2. NISHIKAWA Takeji (50051579)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. IWASAKI Toshiro (50262754)

# of Collaborated Projects: 2 results

# of Collaborated Products: 21 results
4. KUBO Akiharu (70335256)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. ISHIKO Akira (10202988)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. NISHIFUJI Koji (20365422)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
7. HIDEYUKI OKANO (60160694)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
8. SAITO Masataka (30306774)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NAGAO Keisuke (40286521)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. SHIROTA Kinji (70149322)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KOYASU Shigeo (90153684)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. TANAKA Masaru (40188339)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. ANZAI Hidemi (90276345)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Kinoshita Misaki (40594594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. 布袋祐子 (40265898)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 代田欣二 (70147974)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 鈴木春巳 (70235985)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 高橋良 (00317091)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 佐藤洋平 (90736307)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. TSUKASHIMA AKI

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

Ohyama Manabu 大山 学

大山 学 オオヤマ マナブ

OHYAMA Manabu 大山 学

Research Projects

Research Products

Co-Researchers

Assessment of influence of Janus kinase inhibitors on hair follicles using human hair regeneration modelPrincipal Investigator

Principal Investigator

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Attempt to reproduce pathophysiology of skin diseases by use of human three-dimensional skin equivalent with regenerated skin appendage structuresPrincipal Investigator

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Review Section

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Attempt to regenerate skin appendages using reconstituted embryonal-like skin equivalent using human induced pluripotent stem cellsPrincipal Investigator

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Attempt to establish screening system for drug to treat alopecia using human iPS cellsPrincipal Investigator

Principal Investigator

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Development of folliclogenetic tecnique utilizing mesenchymal cells capable of controlling microenvironment

Principal Investigator

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Attempt to regenerate hair follicles using human iPS cell-derived epithelial and mesenchymal cells optimized for trichogenicityPrincipal Investigator

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Investigation of unknown transdifferentiation mechanisms of cutaneous epithelial tumor and related genes

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Analysis of the dynamic skin immune and physical barrier system by tight junctions and Langerhans cells

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Identification of canine hair follicle stem cells, reconstruction Of hair follicle and its application to wound healing

Principal Investigator

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Experimental regeneration of human hair follicles using CD200 positive bulge cellsPrincipal Investigator

Principal Investigator

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天疱瘡自己抗体の3次元エピトープの解析Principal Investigator

Principal Investigator

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Basic studies for development of disease-specific therapeutic strategies against autoimmune diseases

Principal Investigator

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Research Institution

抗原抗体反応速度論的解析による自己抗体病原性強度の新しい指標の開発

Principal Investigator

Ohyama Manabu 大山学

大山学オオヤママナブ

OHYAMA Manabu 大山学