KATAOKA Tohru 片岡徹

Researcher Number	40144472
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2016: 神戸大学, 大学院医学研究科, 教授 2012 – 2016: 神戸大学, 医学(系)研究科(研究院), 教授 2009 – 2011: Kobe University, 医学研究科, 教授 2008 – 2010: Kobe University, 大学院・医学研究科, 教授 2007: Kobe University, 大学院・医学糸研究科, 教授 … More 2005 – 2006: 神戸大学, 大学院医学系研究科, 教授 2001 – 2005: 神戸大学, 大学院・医学系研究科, 教授 1990 – 2000: 神戸大学, 医学部, 教授 Less
Review Section/Research Field	Principal Investigator General medical chemistry / General medical chemistry / Biological Sciences / Pathological medical chemistry Except Principal Investigator Drug development chemistry
Keywords	Principal Investigator ホスホリパーゼC / シクラーゼ結合蛋白質 / アデニル酸シクラーゼ / GTP結合蛋白質 / Adenylyl Cyclase / Ras蛋白質 / 低分子量G蛋白質 / rasがん遺伝子 / 翻訳後修飾 / ras癌遺伝子 … More / raf Oncogene / Adenylyl Cyclase-Associated Protein / Posttranslational Modification / ras Oncogene / ファルネシル化 / ノックアウトマウス / 出芽酵母 / Phospholipase C / Rap1A / raf癌遺伝子 / rap1癌抑制遺伝子 / 線虫 / rafがん遺伝子 / イノシトール脂質代謝 / Rap1蛋白質 / Ras protein / Farnesylation / Raf蛋白質 / がん抑制遺伝子 / グアニンヌクレオチド交換促進因子 / アクチン結合蛋白質 / サイクリックAMP / knockout mice / small G protein / phospholipase C / 心臓半月弁膜症 / Anti-Oncogene / GTP-Binding Protein / RaplA / rap1 Anti-Oncogene / エフェクター / Rasがん遺伝子 / rap1A癌抑制遺伝子 / raplA癌抑制遺伝子 / Ras Protein / Budding Yeast / Cyclase-Associated Protein / RNA helicase / シグナル伝達 / Rap1 / グアニンヌクレオチド交換因子 / RAドメイン / X線結晶解析 / 化学発癌 / CAP / ras蛋白質 / ゲルゾリン / アデニル酸シクラ-ゼ / transgenic mice / cancer promotion / inflammation / inositol phospholipid signaling / トランスジェニックマウス / トランスジュニックマウス / 発癌プロモーション / 炎症反応 / nematodes / semilunar valve disease / ventricular dilation / phosphoinositide signaling / 半月弁狭窄 / 半月弁逆流 / 心室拡張 / Caenorhabditis elegans / Knockout Mice / Rap1 Protein / Intracellular Signal Transduction / Small G Proteins / Inositol Signaling / ゴルジ装置 / 神経系幹細胞 / Ras / 低分子量GTP結合蛋白質 / 細胞内情報伝達 / Guanine Nucleotide Exchange Factor / 低分子GTP結合蛋白質 / rap1A Anti-Oncogene / Ras癌遺伝子 / ホスホリバーゼC / シクラーゼ総合蛋白質 / Actin-binding Protein / CyclicAMP / 細胞質分裂 / 中心体 / 線虫遺伝学 / 合成ペプチド / フォスフォリパーゼC / Cyclic AMP / Ribosomal Protein / cAMP / リボゾーム蛋白質 / リボゾーム蛋白質質 / reversion / cDNA-expression library / ras oncogene / 癌抑制遺伝子 / RNAhelicase / リバ-ジョン / cDNA発現ライブラリ- / アンチセンスRNA / 高分子構造・物性 / 脂質 / 癌 / 蛋白質 / ホスホリパーゼＣ / 表皮角化細胞 / サイトカイン / 発癌 / 炎症 / 癲癇 / Rapl / 癩癇 / 雄性不妊 / 精子形成異常 / 帯状異所性灰白質症 / 神経細胞移動 / 血管形成 / イン・シリコ創薬 / rap1がん抑御遺伝子 / ボスホリパーゼC / インシリコ創薬 / 化学発がん / rap1がん抑制遺伝子 / M-Ras / 細胞増殖因子 / 細胞内局在 / 心臓半月弁弁膜症 / ホルボールエステル / C.elehans / シクラ-ゼ活性化抗体 / 蛋白質間相互作用 / 出芽酵母ras / 反復配列 / がん遺伝子 / ras遺伝子 … More Except Principal Investigator がん遺伝子 / Transcriptional regulation / Growth control / Cancer cells / Tumor suppressor gene / Tumor promoter / Tumor virus / Oncogene / Information exchange / 研究集会 / 研究室訪問 / 北米 / 研究交流 / がん研究 / 転写調節 / 増殖制御 / がん細胞 / がん抑制遺伝子 / 発がんプロモーター / ウイルス発がん / 研究情報交換 / 癌 / シグナル伝達 / がん / 分子標的薬 / 医薬分子設計 / 細胞質分裂 / 線虫C. elegans / アクチン / ras癌遺伝子産物 Less

Research on the molecular basis of conformational dynamics of oncogene product Ras for application to the development of its specific inhibitors
- Principal Investigator
  
  shima fumi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kobe University
Structural study on the role of post-translational lipid modifications of the small G protein RasPrincipal Investigator
- Principal Investigator
  
  KATAOKA TOHRU
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
Elucidation of a novel signaling pathway responsible for the roles of phospholipase Cepsilon in augmentation of inflammation and carcinogenesisPrincipal Investigator
- Principal Investigator
  
  KATAOKA TOHRU
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
Analysis of the function of Rap1-activating factors which mediate the cross-talks between different species of small G proteinsPrincipal Investigator
- Principal Investigator
  
  KATAOKA Tohru
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
Mechanism of cell growth regulation by small G proteinsPrincipal Investigator
- Principal Investigator
  
  KATAOKA Tohru
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
Elucidation of the in vivo function of the Ras/Rap effector phospholipase CεPrincipal Investigator
- Principal Investigator
  
  KATAOKA Tohru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
Analysis of the Regulatory Mechanism and Function of a Novel Class of Phospholipase C, PLCεPrincipal Investigator
- Principal Investigator
  
  KATAOKA Tohru
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
Analysis of the Function of a Novel Class of Mammalian Phospholipase C, PLCεPrincipal Investigator
- Principal Investigator
  
  KATAOKA Tohru
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
低分子量G蛋白質による細胞増殖の制御機構Principal Investigator
- Principal Investigator
  
  片岡徹
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
Molecular Mechanism of Regulation of Effector Activities by Small GTP-binding ProteinsPrincipal Investigator
- Principal Investigator
  
  KATAOKA Tohru
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
Elucidation of the Molecular Mechanism Underlying the Stimulatory Effect of Posttranslational Lipid Modification of Ras Protein on Activation of Its EffectorsPrincipal Investigator
- Principal Investigator
  
  KATAOKA Tohru
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
The Significance of Posttranslational Modification (Farnesylation) of Ras Protein in Activation of Its EffectorsPrincipal Investigator
- Principal Investigator
  
  KATAOKA Tohru
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University School of Medicine
ras癌遺伝子産物とアクチンに結合する新しい細胞質分裂関連蛋白質CEGH
- Principal Investigator
  
  KARIYA Ken-ichi
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
Development of a Strategy for Selective Inhibition of a Particular Ras Function by Interfering Ras-Effector InteractionPrincipal Investigator
- Principal Investigator
  
  KATAOKA Tohru
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kobe University School of Medicine
Mechanism of Intracellular Signaling via Ras ProteinPrincipal Investigator
- Principal Investigator
  
  KATAOKA Tohru
- Project Period (FY)
  1994 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University School of Medicine
The Function of Yeast Adenylyl Cyclase-Associated Proteins in Regulation of Cell Growth and Cytoskeletal StructurePrincipal Investigator
- Principal Investigator
  
  KATAOKA Tohru
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University School of Medicine
ras遺伝子産物とその標的蛋白質の相互作用の機構Principal Investigator
- Principal Investigator
  
  片岡徹
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
The Function of Yeast Adenylyl Cyclase-Associated Proteins in Cell Growth RegulationPrincipal Investigator
- Principal Investigator
  
  KATAOKA Tohru
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
ras遺伝子産物とその標的蛋白質の相互作用の機構Principal Investigator
- Principal Investigator
  
  片岡徹
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
Information Exchange on Cancer Research with North American Countries.
- Principal Investigator
  
  YAMAGUCHI Nobuo
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Institute of Medical Science, University of Tokyo
ras遺伝子産物とその標的蛋白質の相互作用の機構Principal Investigator
- Principal Investigator
  
  片岡徹
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
Isolation of transformation-suppressor genes by using a cDNA-expression library having sense and anti-sense inserts.Principal Investigator
- Principal Investigator
  
  KATAOKA Tohru
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University

[Book] がん分子標的治療2015
- Author(s)
  Fumi Shima, Yoko Yoshikawa, Higeyuki Matsumoto, Tohru Kataoka
- Total Pages
  166
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-26293026
[Book] SPring-8 Research Frontiers 20132014
- Author(s)
  Fumi Shima, Tohru Kataoka
- Total Pages
  154
- Publisher
  SPring-8/JASRI
- Data Source
  KAKENHI-PROJECT-26293065
[Book] がん基盤生物学-革新的シーズ育成に向けて-2013
- Author(s)
  枝松裕紀,片岡徹
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-23390071
[Book] The Enzymes Vol. 34 Inhibitors of the Ras superfamily G-proteins, Part B2013
- Author(s)
  Fumi Shima, Yoko Yoshikawa, Shigeyuki Matsunoto, Tohru Kataoka
- Publisher
  Elsevier Inc.
- Data Source
  KAKENHI-PROJECT-23390071
[Book] がん基盤生物学－革新的シーズ育成に向けて－2013
- Author(s)
  枝松裕紀、片岡徹
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-23390071
[Book] The Enzymes Vol. 34 Inhibitors of the Ras superfamily G-proteins2013
- Author(s)
  Shima, F., Yoshikawa, Y., Matsumoto, S., and Kataoka, T
- Publisher
  Part B (Elsevier)
- Data Source
  KAKENHI-PROJECT-23390071
[Journal Article] Molecular Mechanism for Conformational Dynamics of Ras·GTP Elucidated from In-Situ Structural Transition in Crystal.2016
- Author(s)
  Matsumoto S, Miyano N, Baba S, Liao J, Kawamura T, Tsuda C, Takeda A, Yamamoto M, Kumasaka T, Kataoka T, Shima F.
- Journal Title
  
  Sci Rep.
  
  Volume: - Issue: 1
- DOI
  10.1038/srep25931
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293026, KAKENHI-PROJECT-26293065
[Journal Article] Crucial Role of Rapgef2 and Rapgef6, a Family of Guanine Nucleotide Exchange Factors for Rap1 Small GTPase, in Formation of Apical Surface Adherens Junctions and Neural Progenitor Development in the Mouse Cerebral Cortex.2016
- Author(s)
  Kazuhiro Maeta, Hironori Edamatsu, Kaori Nishihara, Junji Ikutomo, Shymaa E. Bilasy, Tohru Kataoka
- Journal Title
  
  eNeuro
  
  Volume: 3巻 Issue: 3 Pages: ENEURO.0142-16.2016
- DOI
  10.1523/eneuro.0142-16.2016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293065
[Journal Article] Phospholipase Cε activates nuclear factor-κB signaling by causing cytoplasmic localization of ribosomal S6 kinase and facilitating its phosphorylation of inhibitor κB in colon epithelial cells.2016
- Author(s)
  Masahiro Wakita, Hironori Edamatsu, Mingzhen Li, Aki Emi, Sohei Kitazawa, Tohru Kataoka
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 291巻 Issue: 24 Pages: 12586-12600
- DOI
  10.1074/jbc.m116.717561
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293065, KAKENHI-PROJECT-26670176
[Journal Article] Current status of the development of Ras inhibitors.2015
- Author(s)
  Fumi Shima, Shigeyuki Matsumoto, Yoko Yoshikawa, Takashi Kawamura, Masayuki Isa, Tohru Kataoka
- Journal Title
  
  Journal of Biochemistry
  
  Volume: 158 Issue: 2 Pages: 91-99
- DOI
  10.1093/jb/mvv060
- NAID
  40020554051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293065
[Journal Article] rasがん遺伝子産物Rasを分子標的としたがん治療薬開発の現状2015
- Author(s)
  島扶美、吉川陽子、松本篤幸、片岡徹
- Journal Title
  
  がん分子標的治療
  
  Volume: 13巻 Pages: 92-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293065
[Journal Article] Deletion of Rapgef6, a candidate schizophrenia susceptibility gene, disrupts amygdala function in mice.2015
- Author(s)
  R. J. Levy, M. Kvajo, Y. Li, E. Tsvetkov, W. Dong, Yoko Yoshikawa, Tohru Kataoka, V. Y. Bolshakov, M. Karayiorgou, J. A. Gogos
- Journal Title
  
  Translational Psychiatry
  
  Volume: 5 Issue: 6 Pages: e577-e577
- DOI
  10.1038/tp.2015.75
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293065
[Journal Article] Current statue of the development of Ras inhibitors2015
- Author(s)
  Shima F, Matsumoto S, Yoshikawa Y, Kawamura T, Isa M, Kataoka T
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 158 Pages: 91-99
- NAID
  40020554051
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293026
[Journal Article] Critical function of RA-GEF-2/Rapgef6, a guanine nucleotide exchange factor for Rap1, in mouse spermatogenesis2014
- Author(s)
  Okada, K., Miyake, H., Yamaguchi, K., Chiba, K., Maeta, K., Bilasy, S. A., Edamatsu, H., Kataoka, T., and Fujisawa, M
- Journal Title
  
  Biochem. Biophys. Res. Comm
  
  Volume: 445 Issue: 1 Pages: 89-94
- DOI
  10.1016/j.bbrc.2014.01.149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390071
[Journal Article] Phospholipase Cε, an effector of Ras and Rap small GTPases, is required for airway inflammatory response in a mouse model of bronchial asthma.2014
- Author(s)
  Tatsuya Nagano, Hironori Edamatsu, Kazuyuki Kobayashi, Nobuyuki Takenaka, Masatsugu Yamamoto, Naoto Sasaki, Yoshihiro Nishimura, Tohru Kataoka
- Journal Title
  
  PLOS ONE
  
  Volume: 9巻 Issue: 9 Pages: e108373-e108373
- DOI
  10.1371/journal.pone.0108373
- NAID
  120005603833
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590379, KAKENHI-PROJECT-24591131, KAKENHI-PROJECT-26293065
[Journal Article] Akt2 regulates Rac1 activity in the insulin-dependent signaling pathway leading to GLUT4 translocation to the plasma membrane in skeletal muscle cells2013
- Author(s)
  Nozaki, S., Takeda, T., Kitaura, T., Takenaka, N., Kataoka, T., and Satoh, T.
- Journal Title
  
  Cell. Signal
  
  Volume: 25 Issue: 6 Pages: 1361-1371
- DOI
  10.1016/j.cellsig.2013.02.023
- NAID
  120006895711
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390071, KAKENHI-PROJECT-24657140
[Journal Article] In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction2013
- Author(s)
  Shima, F., Yoshikawa, Y., Ye, M., Araki, M., Matsumoto, S., Liao, J., Hu, L., Sugimoto, T., Ijiri, Y., Takeda, A., Nishiyama, Y., Sato, C., Muraoka, S., Tamura, A., Osoda, T., Tsuda, K., Miyakawa, T., Fukunishi, H., Shimada, J., Kumasaka, T., Yamamoto, M., and Kataoka, T
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 110 Issue: 20 Pages: 8182-8187
- DOI
  10.1073/pnas.1217730110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390071
[Journal Article] Role of RalA downstream of Rac1 in insulin-dependent glucose uptake in muscle cells2012
- Author(s)
  Nozaki, S., Ueda, S., Takenaka, N., Kataoka, T., and Satoh, T
- Journal Title
  
  Cell. Signal
  
  Volume: 24 (11) Issue: 11 Pages: 2111-2117
- DOI
  10.1016/j.cellsig.2012.07.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390071, KAKENHI-PROJECT-23700832, KAKENHI-PROJECT-24657140
[Journal Article] Crystal structures of the state 1 conformations of the GTP-bound H-Ras protein and its oncogenic G12V and Q61L mutants2012
- Author(s)
  村岡真
- Journal Title
  
  FEBS Letters
  
  Volume: 586巻・12号 Issue: 12 Pages: 1715-1718
- DOI
  10.1016/j.febslet.2012.04.058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J00683, KAKENHI-PROJECT-23390071
[Journal Article] Overexpression of phospholipase C?in keratinocytes upregulates cytokine expression and causes dermatitis with acanthosis and T-cell infiltration.2011
- Author(s)
  Takenaka, N., Edamatsu, H., Suzuki, N., Saito, H., Inoue, Y., Oka, M., Hu, L., Kataoka, T.
- Journal Title
  
  Eur.J.Immunol. 41
  
  Pages: 202-213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390080
[Journal Article] Phospholipase Cepsilon as a potential molecular target for anti-inflammatory therapy and cancer prevention2011
- Author(s)
  Edamatsu, H., Takenaka, N., Hu, L., and Kataoka, T
- Journal Title
  
  Inflamm. Regen
  
  Volume: 31 Pages: 370-374
- URL
  http://www.jsir.gr.jp/journal/Vol31No4/pdf/08_M6_370.pdf
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390071
[Journal Article] Phospholipase Cε has a crucial role in ultraviolet B-induced neutrophil-associated skin inflammation by regulating the expression of CXCL1/KC2011
- Author(s)
  Oka, M., Edamatsu, H., et al
- Journal Title
  
  Lab.Invest.
  
  Volume: 91 Issue: 5 Pages: 711-718
- DOI
  10.1038/labinvest.2011.10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790290, KAKENHI-PROJECT-23390071, KAKENHI-PROJECT-23591645
[Journal Article] RA-GEF-1 (rapgef2) is essential for proper development of the midline commissures2011
- Author(s)
  Bilasy SE, Satoh T, Terashima T, Kataoka T.
- Journal Title
  
  Neuroscience Research
  
  Volume: 71(3) Issue: 3 Pages: 200-9
- DOI
  10.1016/j.neures.2011.08.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570202, KAKENHI-PROJECT-23390071
[Journal Article] Solution structure of the state 1 conformer of GTP-bound H-Ras protein and distinct dynamic properties between the state 1 and state 2 conformers2011
- Author(s)
  荒木望嗣
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 286巻・45号 Issue: 45 Pages: 39644-39653
- DOI
  10.1074/jbc.m111.227074
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J00683, KAKENHI-PROJECT-23390071
[Journal Article] PLCε cooperates with the NF-κB pathway to augment TNFα-stimulated CCL2/MCP1 expression in human keratinocyte2011
- Author(s)
  Harada, Y., Edamatsu, H., Kataoka, T.
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 414 Issue: 1 Pages: 106-111
- DOI
  10.1016/j.bbrc.2011.09.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790290, KAKENHI-PROJECT-23390071
[Journal Article] Critical Roles of Interactions Among Switch I-preceding Residues and Between Switch II and Its Neighboring α-helix on Conformational Dynamics of the GTP-bound Ras Family Small GTPases2011
- Author(s)
  松本耕祐
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 286巻・17号 Issue: 17 Pages: 15403-15412
- DOI
  10.1074/jbc.m110.204933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J00683, KAKENHI-PROJECT-23390071
[Journal Article] Phospholipase C?has a crucial role in ultraviolet B-induced neutrophil-associated skin inflammation by regulating the expression of CXCL1/KC.2011
- Author(s)
  Oka, M., Edamatsu, H., Kunisada, M., Hu, L., Takenaka, N., Sakaguchi, M., Kataoka, T., Nishigori, C.
- Journal Title
  
  Lab.Invest. 91
  
  Pages: 711-718
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390080
[Journal Article] Critical roles of interactions among switch I-preceding residues and between switch II and its neighboring ?-helix on conformational dynamics of the GTP-bound Ras family small GTPases.2011
- Author(s)
  Matsumoto, K., Shima, F., Muraoka, S., Araki, M., Hu, L., Ijiri, Y., Hirai, R., Liao, J., Yoshioka, T., Kumasaka, T., Yamamoto, M., Tamura, A., Kataoka, T.
- Journal Title
  
  J.Biol.Chem. 286
  
  Pages: 15403-15412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390080
[Journal Article] Structural basis for conformational dynamics of GTP-bound Ras protein.2010
- Author(s)
  Shima, F., Ijiri, Y., Muraoka, S., Liao, J., Ye, M., Araki, M., Matsumoto, K., Yamamoto, N., Sugimoto, T., Yoshikawa, Y., Kumasaka, T., Yamamoto, M., Tamura, A., Kataoka, T.
- Journal Title
  
  J.Biol.Chem. 285
  
  Pages: 22696-22705
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390080
[Journal Article] Structural basis for conformational dynamics of GTP-bound Ras protein.2010
- Author(s)
  Shima, F., Ijiri, Y., Muraoka, S., Liao, J., Ye, M., Araki, M., Matsumoto, K., Yamamoto, N., Sugimoto, T., Yoshikawa, Y., Kumasaka, T., Yamamoto, M., Tamura, A., Kataoka, T.
- Journal Title
  
  J. Biol. Chem. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014061
[Journal Article] Enhancement of ultraviolet B-induced skin tumor development in phospholipase C?-knockout mice is associated with decreased cell death.2010
- Author(s)
  Oka, M., Edamatsu, H., Kunisada, Hu, L., Takenaka, N., M., Dien, S., Kitazawa, R., Kataoka, T., Nishigori, C.
- Journal Title
  
  Carcinogenesis 31
  
  Pages: 1897-1902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390080
[Journal Article] Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma.2010
- Author(s)
  U eda, S., Kitazawa, S., Ishida, K., Nishikawa, Y., Matsui, M., Matsumoto, H., Aoki, T., Nozaki, S., Takeda, T., Tamori, Y., Aiba, A., Kahn, C.R., Kataoka, T., Satoh, T.
- Journal Title
  
  FASEB J. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014061
[Journal Article] Crucial role of phospholipase C・in induction of local skin inflammatory reactions in the elicitation stage of allergic contact hypersensitivity.2010
- Author(s)
  Hu, L., Edamatsu, H., Takenaka, N., Ikuta, S., Kataoka, T.
- Journal Title
  
  J. Immunol. 184
  
  Pages: 993-1002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014061
[Journal Article] Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma.2010
- Author(s)
  Ueda, S., Kitazawa, S., Ishida, K., Nishikawa, Y., Matsui, M., Matsumoto, H., Aoki, T., Nozaki, S., Takeda, T., Tamori, Y., Aiba, A., Kahn, C.R., Kataoka, T., Satoh, T.
- Journal Title
  
  FASEB J. 24
  
  Pages: 2254-2261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390080
[Journal Article] Crucial role of phospholipase C?in induction of local skin inflammatory reactions in the elicitation stage of allergic contact hypersensitivity.2010
- Author(s)
  Hu, L., Edamatsu, H., Takenaka, N., Ikuta, S., Kataoka, T.
- Journal Title
  
  J.Immunol. 184
  
  Pages: 993-1002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390080
[Journal Article] Dorsal telencephalon- specific RA-GEF-1 knockout mice develop heterotropic cortical mass and commissural fiber defect2009
- Author(s)
  Bilasy, S.E., Satoh, T., Ueda, S., Wei, P., Kanemura, H., Aiba, A., Terashima, T., Kataoka, T.
- Journal Title
  
  Eur. J. Neurosci. 29
  
  Pages: 1994-2008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014061
[Journal Article] Phospholipase C?promotes intestinal tumorigenesis of Apc^<Min/+> mice through augmentation of inflammation and angiogenesis.2009
- Author(s)
  Li, M., Edamatsu, H., Kitazawa, R., Kitazawa, R., Kataoka, T.
- Journal Title
  
  Carcinogenesis 30
  
  Pages: 1424-1432
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390080
[Journal Article] Impaired vascular development in the yolk sac and allantois in mice lacking RA-GEF-1.2009
- Author(s)
  Kanemura, H., Satoh, T., Bilasy, S.E., Ueda, S., Hirashima, M., Kataoka, T.
- Journal Title
  
  Biochem. Biophys. Res. Comm. 387
  
  Pages: 754-759
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014061
[Journal Article] Phospholipase C・promotes intestinal tumorigenesis of ApcMin/+ mice through augmentation of inflammation and angiogenesis.2009
- Author(s)
  Li, M., Edamatsu, H., Kitazawa, R., Kitazawa, R., Kataoka, T.
- Journal Title
  
  Carcinogenesis 30
  
  Pages: 1424-1432
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014061
[Journal Article] Dorsal telencephalon-specific RA-GEF-1 knockout mice develop heterotropic cortical mass and commissural fiber defect.2009
- Author(s)
  Bilasy, S. E., Satoh, T., Ueda, S., Wei, P., Kanemura, H., Aiba, A., Terashima, T., Kataoka, T.
- Journal Title
  
  Eur.J.Neurosci. 29
  
  Pages: 1994-2008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390080
[Journal Article] Impaired vascular development in the yolk sac and allantois in mice lacking RA-GEF-1.2009
- Author(s)
  Kanemura, H., Satoh, T., Bilasy, S.E., Ueda, S., Hirashima, M., Kataoka, T.
- Journal Title
  
  Biochem.Biophys.Res.Comm. 387
  
  Pages: 754-759
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390080
[Journal Article] Regulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF10.2009
- Author(s)
  Aoki, T., Ueda, S., Kataoka, T., Satoh, T.
- Journal Title
  
  BMC Cell Biol. 10
  
  Pages: 56-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014061
[Journal Article] Crucial role of phospholipase C・in skin inflammation induced by tumor-promoting phorbor ester.2008
- Author(s)
  Ikuta, S., Edamatsu, H., Li, M., Hu, L., Kataoka, T.
- Journal Title
  
  Cancer Res. 68
  
  Pages: 64-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014061
[Journal Article] Multiple roles of phosphoinositide- specific phospholipase C isozymes.2008
- Author(s)
  Suh, PG., Park, JI., Manzoli, L., Cocco, L., Peak, JC., Katan, M., Fukami, K., Kataoka, T., Yun, S., Ryu, SH.
- Journal Title
  
  BMB Rep. 41
  
  Pages: 415-434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390080
[Journal Article] Two conformational states of Ras GTPase exhibit differential GTP-binding kinetics.2008
- Author(s)
  Liao, J., Shima, F., Araki, M., Ye, M., Muraoka, S., Sugimoto, T., Kawamura, M., Yamamoto, N., Tamura, A., Kataoka, T.
- Journal Title
  
  Biochem.Biophys.Res.Comm. 369
  
  Pages: 327-332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390080
[Journal Article] Activation of the small GTPase Rac1 by a specific nucleotide exchange factor suffices to induce glucose uptake into skeletal muscle cells2008
- Author(s)
  Ueda, S., Kataoka, T., Satoh, T.
- Journal Title
  
  Biol. Cell 100
  
  Pages: 645-657
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014061
[Journal Article] Two conformational states of Ras GTPase exhibit differential GTP-binding kinetics.2008
- Author(s)
  Liao, J., Shima, F., Araki, M., Ye, M., Muraoka, S., Sugimoto, T., Kawamura, M., Yamamoto, N., Tamura, A., Kataoka, T.
- Journal Title
  
  Biochem. Biophys. Res. Comm. 369
  
  Pages: 327-332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014061
[Journal Article] Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1.2007
- Author(s)
  Wei, P., Satoh, T., Edamatsu, H., Aiba, A., Setsu, T., Terashima, T., Kitazawa, S., Nakao, K., Yoshikawa, Y., Tamada, M., Kataoka, T.
- Journal Title
  
  Biochem. Biophys. Res. Comm. 363
  
  Pages: 106-112
- NAID
  120004107908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014061
[Journal Article] Role of the guanine nucleotide exchange factor Ost in negative regulation of receptor endocytosis by the small GTPase Rac1.2007
- Author(s)
  Ieguchi, K., Ueda, S., Kataoka, T., Satoh, T.
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 23296-23305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014061
[Journal Article] The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-・-dependent regulation of integrin activation in splenocytes.2007
- Author(s)
  Yoshikawa, Y., Satoh, T., Tamura, T., Wei, P., Bilasy, S.E., Edamatsu, H., Aiba, A., Katagiri, K., Kinashi, T., Nakao, K., Kataoka, T.
- Journal Title
  
  Mol. Biol. Cell 18
  
  Pages: 2949-2959
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014061
[Journal Article] Phospholipase C・guanine nucleotide exchange factor activity and activation of Rap1.2006
- Author(s)
  Satoh, T., Edamatsu, H., Kataoka, T.
- Journal Title
  
  Methods Enzymol. 407
  
  Pages: 281-290
- Data Source
  KAKENHI-PROJECT-17014061
[Journal Article] Ras and Rap1 activation of PLC・lipase activity.2006
- Author(s)
  Edamatsu, H., Satoh, T., Kataoka, T.
- Journal Title
  
  Methods Enzymol. 407
  
  Pages: 99-107
- Data Source
  KAKENHI-PROJECT-17014061
[Journal Article] Crystal structure of M-Ras reveals a GTP-bound "off" state conformation of Ras family small GTPases.2005
- Author(s)
  Ye, M., Shima, F., Muraoka, S., Liao, J., Okamoto, H., Yamamoto, M., Tamura, A., Yagi, N., Ueki, T., Kataoka, T.
- Journal Title
  
  J. Biol. Chem. 280
  
  Pages: 31267-31275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014061
[Journal Article] Congenital semilunar valvulogenesis defect in mice deficient in phospholipase C・2005
- Author(s)
  Tadano, M., Edamatsu, H., Minamisawa, S., Yokoyama, U., Ishikawa, Y., Suzuki, N., Wu, D., Masago-Toda, M., Yamawaki-Kataoka, Y., Setsu, T., Terashima, T., Maeda, S., Satoh, T., Kataoka, T.
- Journal Title
  
  Mol. Cell. Biol. 25
  
  Pages: 2191-2199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014061
[Journal Article] エフェクター活性化過程に必須であるRasの翻訳後修飾-Ras-エフェクター相互作用の高次構造解析2005
- Author(s)
  島扶美、片岡徹
- Journal Title
  
  生化学 77
  
  Pages: 519-526
- NAID
  10016452222
- Data Source
  KAKENHI-PROJECT-17014061
[Patent] Ras機能阻害剤のスクリーニング方法2012
- Inventor(s)
  片岡徹、島扶美、田村厚夫、荒木望嗣
- Industrial Property Rights Holder
  神戸大学
- Filing Date
  2012-01-31
- Overseas
- Data Source
  KAKENHI-PROJECT-23390071
[Patent] Ras機能阻害剤のスクリーニング方法2011
- Inventor(s)
  片岡徹、島扶美、田村厚夫、荒木望嗣
- Industrial Property Rights Holder
  神戸大学
- Industrial Property Number
  2011-023695
- Filing Date
  2011-02-07
- Data Source
  KAKENHI-PROJECT-20390080
[Patent] 変異型Rasポリペプチドの結晶2010
- Inventor(s)
  片岡徹、島扶美、田村厚夫、熊坂崇
- Industrial Property Rights Holder
  神戸大学、財団法人高輝度光科学研究センター
- Filing Date
  2010-07-13
- Overseas
- Data Source
  KAKENHI-PROJECT-20390080
[Patent] 変異型Rasポリペプチドの結晶2010
- Inventor(s)
  片岡徹、島扶美、田村厚夫、熊坂崇
- Industrial Property Rights Holder
  神戸大学、高輝度光科学研究センター
- Filing Date
  2010-07-13
- Data Source
  KAKENHI-PROJECT-20390080
[Patent] 変異型Rasポリペプチドの結晶2009
- Inventor(s)
  片岡徹、島扶美、田村厚夫、熊坂崇
- Industrial Property Rights Holder
  神戸大学、高輝度光科学研究センター
- Industrial Property Number
  2009-165717
- Filing Date
  2009-07-14
- Data Source
  KAKENHI-PROJECT-17014061
[Patent] 変異型Rasポリペプチドの結晶2009
- Inventor(s)
  片岡徹、島扶美、田村厚夫、熊坂崇
- Industrial Property Rights Holder
  神戸大学、高輝度光科学研究センター
- Industrial Property Number
  2009-165717
- Filing Date
  2009-07-14
- Data Source
  KAKENHI-PROJECT-20390080
[Patent] ホスホリパーゼCεを分子標的とした新規抗炎症薬のスクリーニング方法および尋常性乾癬様の慢性皮膚炎モデル動物2007
- Inventor(s)
  片岡徹、枝松裕紀、竹中延之
- Industrial Property Rights Holder
  神戸大学
- Industrial Property Number
  2007-285792
- Filing Date
  2007-11-02
- Data Source
  KAKENHI-PROJECT-17014061
[Patent] ホスホリパーゼC・を分子標的とした新規抗炎症薬のスクリーニング方法、および尋常性乾癬様の慢性皮膚炎モデル動物2007
- Inventor(s)
  片岡徹、枝松裕紀、竹中延之権利者:神戸大学
- Industrial Property Rights Holder
  神戸大学
- Industrial Property Number
  2007-285792
- Filing Date
  2007-11-02
- Data Source
  KAKENHI-PROJECT-17014061
[Patent] ホスホリパーゼCεを分子標的とした新規抗がん剤のスクリーニング方法2004
- Inventor(s)
  片岡徹, 枝松裕紀
- Industrial Property Rights Holder
  神戸大学
- Industrial Property Number
  2004-022308
- Filing Date
  2004-01-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390093
[Patent] ホスホリパーゼCεを分子標的とした新規抗がん剤のスクリーニング方法2004
- Inventor(s)
  片岡徹, 枝松裕紀
- Industrial Property Rights Holder
  片岡徹, 枝松裕紀
- Industrial Property Number
  2004-022308
- Filing Date
  2004-01-29
- Data Source
  KAKENHI-PROJECT-12215098
[Presentation] Development of anti-cancer drugs targeting the Ras signaling pathway2016
- Author(s)
  Tohru Kataoka
- Organizer
  Trans-Pacific Netwark for Drug Discovery and Identification of New Therapeutic Targets Kick-off Symposium
- Place of Presentation
  Kobe University Graduate School of Medicine Kobe (Hyogo)
- Year and Date
  2016-03-22
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293065
[Presentation] rasがん遺伝子産物を分子標的としたがん治療薬のインシリコ創薬2016
- Author(s)
  片岡徹
- Organizer
  第14回次世代を担う若手のためのフィジカル・ファーマフォーラム（日本薬学会物理系薬学部会）
- Place of Presentation
  ロッジ舞洲（大阪府・大阪市）
- Year and Date
  2016-08-27
- Invited
- Data Source
  KAKENHI-PROJECT-26293065
[Presentation] Sortase Aを利用した翻訳後脂質修飾型Rasの産生と構造物学研究2016
- Author(s)
  村嶋　陽亮、柯　浩亮、松本　篤幸、枝松　裕紀、片岡　徹
- Organizer
  第14回次世代を担う若手のためのフィジカル・ファーマフォーラム（日本薬学会物理系薬学部会）
- Place of Presentation
  ロッジ舞洲（大阪府・大阪市）
- Year and Date
  2016-08-27
- Data Source
  KAKENHI-PROJECT-26293065
[Presentation] Structure-based drug design of small-molecule Ras inhibitors having anti-tumor activity2016
- Author(s)
  Tohru Kataoka
- Organizer
  第14回日本臨床腫瘍学会学術集会
- Place of Presentation
  神戸国際展示場・神戸国際会議場（兵庫県・神戸市）
- Year and Date
  2016-07-29
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293065
[Presentation] rasがん遺伝子産物を分子標的とした抗がん剤のインシリコ創薬2015
- Author(s)
  片岡徹
- Organizer
  情報計算化学生物学会 (CBI学会) シンポジウム「アカデミア創薬」
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-10-28
- Invited
- Data Source
  KAKENHI-PROJECT-26293065
[Presentation] Structure-based drug design of anti-cancer compounds targeting Ras oncoproteins.2015
- Author(s)
  Tohru Kataoka
- Organizer
  Workshop on Innovation and Pioneering Technology (WINTech) 2015 “Innovation by Synergy of Computational & Synchrotron Radiation Sciences”
- Place of Presentation
  神戸大学統合研究拠点コンベンションホール（兵庫県神戸市）
- Year and Date
  2015-03-12
- Invited
- Data Source
  KAKENHI-PROJECT-26293065
[Presentation] Development of anti-cancer drugs targeting the Ras signaling pathway2015
- Author(s)
  Tohru Kataoka
- Organizer
  2015 Kobe University-Taipei Medical University Joint Symposium
- Place of Presentation
  Taipei Medical College Taipei (Taiwan)
- Year and Date
  2015-12-22
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293065
[Presentation] New strategies for development of anti-cancer drugs targeting the Ras pathway2015
- Author(s)
  Tohru Kataoka
- Organizer
  Joint Symposium of Universite de Liege and Kobe University “Recent cancer research from bases to clinical site”
- Place of Presentation
  Kobe University Graduate School of Medicine Kobe (Hyogo)
- Year and Date
  2015-05-13
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293065
[Presentation] 分子標的がん治療薬の開発とSPring-82014
- Author(s)
  片岡徹
- Organizer
  SPring-8/SACLAコンファレンス2014「進化する光が拓く科学技術」
- Place of Presentation
  JPタワーホール&カンファレンス（東京都千代田区）
- Year and Date
  2014-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-26293065
[Presentation] アカデミア発、rasがん遺伝子産物を分子標的にした抗がん剤の開発2014
- Author(s)
  片岡徹
- Organizer
  CBI学会第349回研究講演会「日本版NIHの現状とオープンイノベーションの成果」
- Place of Presentation
  グランフロント大阪（大阪府大阪市）
- Year and Date
  2014-04-11
- Invited
- Data Source
  KAKENHI-PROJECT-26293065
[Presentation] 気道炎症におけるホスホリパーゼCεの役割2013
- Author(s)
  永野達也,枝松裕紀,小林和幸,西村善博,片岡徹
- Organizer
  第4回IAA学術集会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2013-04-21
- Data Source
  KAKENHI-PROJECT-23390071
[Presentation] ras がん遺伝子産物の分子標的薬のインシリコ創薬2013
- Author(s)
  片岡徹
- Organizer
  平成25年度臨床研究総合センターシンポジウム~がん治療最前線 : ゲノム創薬と免疫治療~
- Place of Presentation
  千葉県がんセンター
- Year and Date
  2013-12-07
- Data Source
  KAKENHI-PROJECT-23390071
[Presentation] 癌の発生機構の基礎研究に基づく新しい癌治療薬の創薬2013
- Author(s)
  片岡　徹
- Organizer
  第23回生物試料分析科学会年次学術集会
- Place of Presentation
  新梅田研修センター(大阪市)
- Invited
- Data Source
  KAKENHI-PROJECT-23390071
[Presentation] New strategies for development of anti-cancer drugs targeting the Ras signaling pathway2013
- Author(s)
  Tohru Kataoka
- Organizer
  WINPTech 2012: Recent Development in Drug Discovery Sciences
- Place of Presentation
  神戸大学統合拠点(神戸市)
- Invited
- Data Source
  KAKENHI-PROJECT-23390071
[Presentation] New strategies for development of anti-cancer drugs targeting the Ras family signaling pathway2013
- Author(s)
  Kataoka, T
- Organizer
  WINPTech 2012 : Recent Development in Drug Discovery Sciences
- Place of Presentation
  神戸大学統合拠点
- Data Source
  KAKENHI-PROJECT-23390071
[Presentation] Ras シグナル伝達系を標的とした抗がん剤の開発2013
- Author(s)
  片岡徹
- Organizer
  大阪大学産学連携プロジェクト MEET 医学研究コロキウム・1-がんの分子標的治療を考える-
- Place of Presentation
  大阪大学大学院医学研究科
- Year and Date
  2013-10-07
- Data Source
  KAKENHI-PROJECT-23390071
[Presentation] 癌の発生機構の基礎研究に基づく新しい癌治療薬の創薬2013
- Author(s)
  片岡徹
- Organizer
  第23回生物試料分析化学会年次学術集会
- Place of Presentation
  新梅田研修センター
- Data Source
  KAKENHI-PROJECT-23390071
[Presentation] New strategies for development of anti-cancer drugs targeting the Ras pathway2012
- Author(s)
  Tohru Kataoka
- Organizer
  The 2^<nd> International Symposium on Cancer and Cancer Stem Cells Research in Toyama
- Place of Presentation
  富山大学(富山県)(招待講演)
- Year and Date
  2012-02-28
- Data Source
  KAKENHI-PROJECT-23390071
[Presentation] Crucial role of phospholipase Cepsilon in colitis-induced colon tumor formation in ApcMin mice(日本語演題名 : ApcMin マウスの腸炎誘発性大腸腺腫発生におけるホスホリパーゼ Cεの重要な役割)2012
- Author(s)
  脇田将裕,枝松裕紀,北澤荘平,片岡徹
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2012-12-11
- Data Source
  KAKENHI-PROJECT-23390071
[Presentation] New strategies for development of anti-cancer drugs targeting the Ras pathway2012
- Author(s)
  Kataoka, T
- Organizer
  The 2nd International Symposium on Cancer and Cancer Stem Cells Research in Toyama
- Place of Presentation
  富山大学
- Year and Date
  2012-02-28
- Data Source
  KAKENHI-PROJECT-23390071
[Presentation] Crucial role of phospholipase Cepsilon in the development of asthma in mice2011
- Author(s)
  Nagano, T., Edamatsu, H., Kobayashi, K., Nishimura, Y., and Kataoka, T.
- Organizer
  European Respiratory Society Annual Congress(欧州呼吸器学会年会)
- Place of Presentation
  Amsterdam RAI( オランダ)
- Year and Date
  2011-09-25
- Data Source
  KAKENHI-PROJECT-23390071
[Presentation] Overexpression of phospholipase Cepsilon in keratinocytes results in IL-23 production leading to skin inflammation accompanied by IL-22-producing T cell infiltration2011
- Author(s)
  Edamatsu, H., Takenaka, N., and Kataoka, T.
- Organizer
  10th World Congress on Inflammation
- Place of Presentation
  Paris Convention Centre(フランス)
- Year and Date
  2011-06-27
- Data Source
  KAKENHI-PROJECT-23390071
[Presentation] Universal roles of phospholipase Cepsilon in de novo carcinogenesis and inflammation2011
- Author(s)
  Kataoka, T
- Organizer
  2011 Taiwan-Japan Joint Symposium on Cell Signaling and Gene Regulation
- Place of Presentation
  National Cheng Kung University (台湾)
- Year and Date
  2011-11-20
- Data Source
  KAKENHI-PROJECT-23390071
[Presentation] Universal roles of phospholipase Cε in de novo carcinogenesis and inflammation2011
- Author(s)
  Tohru Kataoka
- Organizer
  2011 Taiwan-Japan Joint Symposium on Cell Signaling and Gene Regulation
- Place of Presentation
  National Cheng Kung University (台湾)(招待講演)
- Year and Date
  2011-11-20
- Data Source
  KAKENHI-PROJECT-23390071
[Presentation] rasがん遺伝子産物を標的とした新規抗がん剤の開発2010
- Author(s)
  片岡徹
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪府)
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-20390080
[Presentation] rasがん遺伝子産物を標的とした新規抗がん剤の開発2010
- Author(s)
  片岡徹
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪府)(招待講演)
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-20390080
[Presentation] Roles of Ras/Rap effectors in biomembrane functions and their therapeutic applications2008
- Author(s)
  Tohru Kataoka
- Organizer
  International Symposium on Integrative Membrane Biology
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2008-12-18
- Data Source
  KAKENHI-PROJECT-20390080
[Presentation] Roles of Ras/Rap effectors in biomembrane functions and their therapeutic applications2008
- Author(s)
  Tohru Kataoka
- Organizer
  International Symposium on Integrative Membrane Biology
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2008-12-18
- Data Source
  KAKENHI-PROJECT-17014061
[Presentation] Universal roles of phospholipase C・in de novo carcinogenesis and inflammation.2008
- Author(s)
  Kataoka, T.
- Organizer
  Pohang Conference on Cellular Signaling
- Place of Presentation
  Pohang(韓国)
- Year and Date
  2008-02-21
- Data Source
  KAKENHI-PROJECT-17014061
[Presentation] Roles of Ras/Rap effectors in biomembrane functions and their therapeutic applications.2008
- Author(s)
  片岡徹
- Organizer
  International Symposium on Integrative Membrane Biology
- Place of Presentation
  神戸国際会議場(兵庫県)
- Year and Date
  2008-12-18
- Data Source
  KAKENHI-PROJECT-20390080
[Presentation] Universal roles of phospholipase Cε in de novo carcinogenesis and inflammation2008
- Author(s)
  片岡徹
- Organizer
  Pohang Conference on Cellular Singaling
- Place of Presentation
  Phang, Korea
- Year and Date
  2008-02-21
- Data Source
  KAKENHI-PROJECT-17014061
[Presentation] Roles of Ras/Rap effectors in biomembrane functions and their therapeutic applications.2008
- Author(s)
  Kataoka, T.
- Organizer
  International Symposium on Integrative Membrane Biology
- Place of Presentation
  神戸国際会議場(兵庫県)
- Year and Date
  2008-12-18
- Data Source
  KAKENHI-PROJECT-17014061
[Presentation] Universal roles of phospholipase CE in de novo carcinogenesis and inflammation2008
- Author(s)
  Tohru Kataoka
- Organizer
  International Workshop of Kobe Univ. Global CC E Program "New Frontier of Membrane Biology"
- Place of Presentation
  兵庫県淡路市
- Year and Date
  2008-07-02
- Data Source
  KAKENHI-PROJECT-17014061
[Presentation] Rasを分子標的とした抗がん剤のインシリコ創薬2007
- Author(s)
  片岡徹
- Organizer
  第69回日本血液学会/第49回日本臨床血液学会合同総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-12
- Data Source
  KAKENHI-PROJECT-17014061
[Presentation] Rasを分子標的とした抗がん剤のインシリコ創薬2007
- Author(s)
  片岡徹
- Organizer
  第69回日本血液学会/第49回日本臨床血液学会合同総会シンポジウム「シグナル伝達研究と分子標的療法」
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2007-10-12
- Data Source
  KAKENHI-PROJECT-17014061
[Presentation] Rasファミリー低分子量Gタンパク質の高次構造遷移:その機能と創薬への展開2006
- Author(s)
  片岡徹
- Organizer
  21世紀COE合同シンポジウム「シグナル伝達と構造生物学の接点」
- Place of Presentation
  先端技術支援センター(兵庫県)
- Year and Date
  2006-12-09
- Data Source
  KAKENHI-PROJECT-17014061
[Presentation] New strategies for development of anti-cancer drugs targeting the Ras pathway2006
- Author(s)
  Kataoka, T.
- Organizer
  International Symposium of Kobe University 21st Century COE Program on Signal Transduction
- Place of Presentation
  神戸国際会議場(兵庫県)
- Year and Date
  2006-02-09
- Data Source
  KAKENHI-PROJECT-17014061
[Presentation] Specific inhibitors of Ras oncoprotein identified by a new strategy.2006
- Author(s)
  Kataoka, T.
- Organizer
  International Symposium on TOR-Signaling Mechanisms in the Cell Growth Regulation.
- Place of Presentation
  神戸大学(兵庫県)
- Year and Date
  2006-11-30
- Data Source
  KAKENHI-PROJECT-17014061
[Presentation] Rasシグナル伝達系を標的とした抗がん剤の開発
- Author(s)
  片岡　徹
- Organizer
  大阪大学産学連携プロジェクトMEET　医学研究コロキウム・１-がんの分子標的治療を考える-
- Place of Presentation
  大阪大学大学院医学研究科
- Invited
- Data Source
  KAKENHI-PROJECT-23390071
[Presentation] Universal roles of phospholipase Cε in carcinogenesis and inflammation.
- Author(s)
  Tohru Kataoka
- Organizer
  5th International Symposium on Carcinogenic Spiral “Infection, Immunity, and Cancer”
- Place of Presentation
  神戸ポートピアホテル（兵庫県神戸市）
- Year and Date
  2015-02-26 – 2015-02-27
- Invited
- Data Source
  KAKENHI-PROJECT-26293065
[Presentation] rasがん遺伝子産物の分子標的薬のインシリコ創薬
- Author(s)
  片岡　徹
- Organizer
  平成２５年度臨床研究総合センターシンポジウム～がん治療最前線：ゲノム創薬と免疫治療～
- Place of Presentation
  千葉県がんセンター
- Invited
- Data Source
  KAKENHI-PROJECT-23390071
[Presentation] 気道炎症におけるホスホリパーゼＣεの役割
- Author(s)
  永野　達也、枝松　裕紀、小林　和幸、西村　善博、片岡　徹
- Organizer
  第4回IAA (Innovative Asthma Association) 学術集会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-23390071

1. SHIMA Fumi (60335445)

# of Collaborated Projects: 9 results

# of Collaborated Products: 22 results
2. KATAOKA Yuriko (50233739)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
3. EDAMATSU Hironori (70335438)

# of Collaborated Projects: 8 results

# of Collaborated Products: 28 results
4. KARIYA Ken-ichi (40263371)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
5. SUZUKI Noboru (00202135)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
6. SATOH Takaya (20251655)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
7. OKADA Tomoyo (80294205)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. HU Chang-deng (70294204)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. 松本篤幸 (00753906)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
10. HIRASHIMA Masanori (40383757)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. KITAHARA Ryou (70512284)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. YAMAGUCHI Nobuo (90012723)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. HAMADA Hirofumi (00189614)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KOUNO Kimitoshi (00153479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. TAKAHASHI Takashi (50231395)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. TANIGUCHI Naoyuki (90002188)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. YOSHIKI Takashi (60220612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. IKEUCHI Taturou (90041839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. YOSHIDA Mituaki (80012607)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. ISHIBASHI Masahide (70029776)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. SIBUYA Masabumi (10107427)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. CHIDA Kazuhiro (00192188)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. NODA Tetuo (10183550)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. FUJISAWA Jun-ichi (40181341)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. NAKABEPPU Yuusaku (30180350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. TAKAHASHI Rei (60144565)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. SASAKI Takuya (40241278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 田中成典 (10379480)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 熊坂崇 (30291066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
30. 阿部周一 (80125278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 根本信雄 (10085631)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 菅村和夫 (20117360)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 須川秀夫 (70162857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 田中伸之 (80222115)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 内海博司 (20025646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 今井高志 (50183009)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 小幡裕一 (30177290)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 加藤勝 (50233820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 伊藤嘉明 (80004612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 森井成人 (80220036)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. 平井久丸 (90181130)

# of Collaborated Projects: 1 results

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42. 武部啓 (10028318)

# of Collaborated Projects: 1 results

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43. 伊庭英夫 (60111449)

# of Collaborated Projects: 1 results

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44. 清木元治 (10154634)

# of Collaborated Projects: 1 results

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45. 武市紀年 (40002133)

# of Collaborated Projects: 1 results

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46. 石崎寛治 (70111987)

# of Collaborated Projects: 1 results

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47. 首藤紘一 (50012612)

# of Collaborated Projects: 1 results

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48. 菊池章 (10204827)

# of Collaborated Projects: 1 results

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49. 山口政光 (00182460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
50. 安本茂 (00112342)

# of Collaborated Projects: 1 results

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51. 佐竹正延 (50178688)

# of Collaborated Projects: 1 results

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52. 山本雅 (40134621)

# of Collaborated Projects: 1 results

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53. 秋山徹 (70150745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
54. TSUKUMA Hideaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
55. 寺島俊雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KATAOKA Tohru 片岡 徹

Research Projects

Research Products

Co-Researchers

Research on the molecular basis of conformational dynamics of oncogene product Ras for application to the development of its specific inhibitors

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Structural study on the role of post-translational lipid modifications of the small G protein RasPrincipal Investigator

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Elucidation of a novel signaling pathway responsible for the roles of phospholipase Cepsilon in augmentation of inflammation and carcinogenesisPrincipal Investigator

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Analysis of the function of Rap1-activating factors which mediate the cross-talks between different species of small G proteinsPrincipal Investigator

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Mechanism of cell growth regulation by small G proteinsPrincipal Investigator

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Elucidation of the in vivo function of the Ras/Rap effector phospholipase CεPrincipal Investigator

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Analysis of the Regulatory Mechanism and Function of a Novel Class of Phospholipase C, PLCεPrincipal Investigator

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Analysis of the Function of a Novel Class of Mammalian Phospholipase C, PLCεPrincipal Investigator

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低分子量G蛋白質による細胞増殖の制御機構Principal Investigator

Principal Investigator

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Review Section

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Molecular Mechanism of Regulation of Effector Activities by Small GTP-binding ProteinsPrincipal Investigator

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Elucidation of the Molecular Mechanism Underlying the Stimulatory Effect of Posttranslational Lipid Modification of Ras Protein on Activation of Its EffectorsPrincipal Investigator

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The Significance of Posttranslational Modification (Farnesylation) of Ras Protein in Activation of Its EffectorsPrincipal Investigator

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ras癌遺伝子産物とアクチンに結合する新しい細胞質分裂関連蛋白質CEGH

Principal Investigator

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KATAOKA Tohru 片岡徹