Yamamoto Hiroyuki 山本博幸

… Alternative Names

YAMAMOTO Hiroyuki 山本博幸

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Researcher Number	40332910
Other IDs
Affiliation (Current)	2024: 聖マリアンナ医科大学, 医学研究科, 教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 聖マリアンナ医科大学, 医学研究科, 教授 2013 – 2020: 聖マリアンナ医科大学, 医学部, 准教授 2008 – 2012: 札幌医科大学, 医学部, 講師 2007: Sapporo Medical University, School of Medicine, Instructor 2001 – 2006: Sapporo Medical University, School of Medicine, First Department of Internal Medicine, Instructor, 医学部, 助手
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology / Basic Section 52010:General internal medicine-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor diagnosis / Cancer epidemiology and prevention / Biological Sciences Except Principal Investigator Gastroenterology / Gastroenterology / Basic Section 52010:General internal medicine-related … More / Basic Section 53010:Gastroenterology-related / Basic Section 09070:Educational technology-related / Tumor diagnostics / Laboratory medicine Less
Keywords	Principal Investigator 胃癌 / マイクロサテライト不安定性 / DNAメチル化 / Akt / dominant negative / 消化器癌 / H. pylori / tyrosine kinase inhibitor / microsatellite instability / 3'-UTR … More / 5'-UTR / 大腸癌 / 内視鏡AI / 革新的胃癌統合医療 / 新型ゲノムデータ / 人工知能 / 胃洗浄廃液 / ゲノム多様性 / ゲノム解析 / 間質細胞 / DNA組み込み / EBV / IGF- 1 receptor / gastrointestinal cancer / extracellular matrix degrading enzyme / insulin-like growth factor / bystander効果 / Akt-1 / IGF-I receptor / ERK / 細胞外基質分解酵素 / IGF1 receptor / 細胞外基質分解酵 / インスリン様増殖因子 / non-coding region / DNA mismatch repair gene / 遺伝子発現 / non-coding領域 / DNAミスマッチ修復遺伝子 / オミクス解析 / エピゲノム / ゲノム / 食道癌 / HPV / LINE-1 / MCA microarray / 粘膜内癌 / 背景粘膜 / microRNA / メチル化 / DNA / 食道扁平上皮癌 / マイクロRNA / SNP / 分子疫学 / 日米欧比較 / 機能性RNA / アデノウイルス / 浸潤先進部 / protein array / 分子標的治療法 / proprotein convertase / マトリライシン / loss of imprinting / IGI-Iレセプター / IGF / CIMP / DNAメチレーション / Hox遺伝子 / β2マイクログロブリン遺伝子 / SEC63遺伝子 / MMP-3遺伝子 / HLA遺伝子 / 民族間比較 / BRAF遺伝子 / MRE11遺伝子 / 免疫応答 / aberrant oligopeptide / フレームシフト変異 / 標的遺伝子 … More Except Principal Investigator メチル化 / 肝癌 / DNAメチル化 / 消化器癌 / 遺伝子不安定性 / methylation / cell cycle / Barrett's esophagus / 消火器癌 / バイオマーカー / 前癌病変 / GIST / 遺伝子診断 / エピジェネティクス / 血液診断 / 生体機能情報 / ウイルスゲノム組み込み / 胆道癌 / 膵癌 / ピロリ菌 / 胃洗浄廃液 / HBV / Ln-γ2 / NNK / chemo prevention / Bcl-2 / DNAアレイ / gastrointestinal cancer / CHFR / CIMP / DNA methylation / p16 / mucin / MSI / 肝細胞癌 / エピゲノム / 抗体治療 / 遺伝子変異 / マイクロRNA / 分子標的 / 腫瘍マーカー / 分子標的治療 / 子宮頸癌 / 血中可視化 / ヒトパピローマウイルス / 子宮頚癌 / HPV / 逆行性シグナル伝達 / HBV組み込み / ミトコンドリア / laminin-γ2 / AI診断 / 内視鏡 / 分子マーカー / 診断マーカー / 内視鏡AI診断 / ESD / ピロリ菌遺伝子異常 / 遺伝子メチル化異常 / 早期胃がん / Mixed Reality / MRシステム / 視線追跡装置 / トレーニングシステム / 内視鏡的粘膜下層剥離術 / 胆管癌 / 膵臓癌 / ラミニン / ゲノム解析 / 23SrRNA / パックバイオ解析 / 挿入 / パイロシークエンス / 次世代シークエンス解析 / 遺伝子異常 / 胃がん / DNA組み込み / ラミニンγ2 / サーベイランス / AFP / PIVKA-2 / ラミニンγ２短鎖 / prediction of cancer risk / genetic diagnosis / epigenetics / 発癌リスク予測 / DNA demethylation agent / hepatocellular carcinoma / DNA array / NNKラット / 脱メチル化剤 / PPI / 酸分泌抑制剤 / 細胞増殖能 / Barrett粘膜 / proton pump inhibitor(PPI) / diagnosis / malignant potential / VEGF recepter / cDNA array / 診断 / 悪性度 / VEGF受容体 / 消化管間葉系腫瘍 / taxane / anti-cancer drug sensitivity / histone acetylation / methylation inhibitor / チェックポイント / CHFR遺伝子 / CpGアイランド / ヒストン脱アセチル化 / タキサン / 抗癌剤感受性 / ヒストン脱アセチル化剤 / メチル化阻害剤 / Gastrointestinal cancer / Molecular target therapy / Epigenetics / Genetic instability / 癌発生 / メチル化異常 / ヒストン / bio-marker for carcinogenesis / risk factor for carcinogenesis / early diagnosis / hepatocarcinogenesis / suppressor gene / 細胞周期制御遺伝子 / 発癌 / 発癌予測マーカー / 発癌高危険群 / 発癌生体マーカー / 発癌危険因子 / 早期診断 / 肝発癌 / 癌抑制遺伝子 / 細胞周期 / pit pattern / Barrett's adenocarcinoma / 拡大内視鏡診 / 腸上皮化生 / ムチン分子 / Barrett食道 / angiogenesis / narrow band imaging / magnifying endoscopy / Cancer vaccine / Immunological diagnosis / Gastrointestinal tumor / Microsatellite instability / 変異オリゴペプチド / β2-マイクログロブリン / 標的遺伝子変異 / 癌ワクチン / 免疫学的診断 / マイクロサテライト不安定性 / pyrosequencing / PDGFR / VEGFR / 治療効果予測 / Sorafenib / 食道がん / 食道癌 / homologous recombination / 食道扁平上皮癌 / 放射線化学療法 / カイコ抗体 / 肝がん / 三重特異性抗体 / HOTAIR / miR-196a / 消化管癌 / 大腸癌 / 胃癌 / 上部消化管学 / 癌 / 分子改変 / 肝臓学 / H. pylori / H.pylori / LINE-1 / hypomethylation / hypermethylation / Gene expression / 標的遺伝子 / マイクロ RNA / 消化管間質腫瘍 / 治療 / 抗体 / FGFR-1 / インターフェロン / 遺伝子発現 / 個別化医療 / ヒストン修飾 Less

膵・胆道系を標的とする革新的新規腫瘍マーカー・ラミニンγ2とその機能解析
- Principal Investigator
  
  安田宏
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  St. Marianna University School of Medicine
A novel mechanism of carcinogenesis through retrograde signaling by HBV incorporation into mitochondria
- Principal Investigator
  
  及川律子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  St. Marianna University School of Medicine
ウイルスゲノム組み込みと生体機能情報のリアルタイム血中可視化による子宮頸癌の制御
- Principal Investigator
  
  伊東文生
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  St. Marianna University School of Medicine
人工知能・新型ゲノムデータ駆動型アプローチに基づく革新的胃癌統合医療の創成Principal Investigator
- Principal Investigator
  
  山本博幸
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  St. Marianna University School of Medicine
視線追跡装置を用いた消化器内視鏡治療技術の可視化によるトレーニングシステム開発
- Principal Investigator
  
  前畑忠輝
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 09070:Educational technology-related
- Research Institution
  St. Marianna University School of Medicine
ヒト・ピロリ菌分子マーカー＋内視鏡AI診断による超早期胃がん診断パネルの構築
- Principal Investigator
  
  渡邊嘉行
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  St. Marianna University School of Medicine
Biological activity and potential role of laminin-gamma2 as a novel biomarker for pancreatic ductal carcinoma
- Principal Investigator
  
  Yasuda Hiroshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  St. Marianna University School of Medicine
Novel suppression of gastric carcinogenesis based on the spatiotemporal elucidation of H. pylori genome alterations identified using clinical samplesPrincipal Investigator
- Principal Investigator
  
  Yamamoto Hiroyuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  St. Marianna University School of Medicine
Suppression of hepatocarcinogenesis based on the real-time blood-borne visualization of viral genome integration and biofunctional information
- Principal Investigator
  
  Fumio Itoh
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  St. Marianna University School of Medicine
Molecular diagnostic markers for early gastric cancer using Human and H.Pylori genome alterations
- Principal Investigator
  
  Watanabe Yoshiyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  St. Marianna University School of Medicine
Elucidation and regulation of gastric carcinogeneis based on the next-generation integrated analysis of DNA integration and stromal cellsPrincipal Investigator
- Principal Investigator
  
  Yamamoto Hiroyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  St. Marianna University School of Medicine
Potential role of monomeric laminin-gamma 2 as a novel biomarker for hepatocellular carcinoma.
- Principal Investigator
  
  Yasuda Hiroshi
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  St. Marianna University School of Medicine
Suppression of hepatocarcinogeneis based on the elucidation of HBV integration and epigenome alterations analyzed by G-NaVI
- Principal Investigator
  
  Itoh Fumio
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor diagnostics
- Research Institution
  St. Marianna University School of Medicine
DSB-HR diagnostic system predicting the sensitivity for chemoradiation therapy in esophageal cancer
- Principal Investigator
  
  Maehata Tadateru
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
Development of molecular diagnostic system for the prediction of therapeutic effect in liver cancer
- Principal Investigator
  
  Okuse Chiaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  St. Marianna University School of Medicine
Integrated analysis of HPV integration and epigenome for early diagnosis, treatment and prevention of esophageal cancerPrincipal Investigator
- Principal Investigator
  
  Yamamoto Hiroyuki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  St. Marianna University School of Medicine
Establishment of a treatment for advanced hepatocellular carcinoma using a tri-functional silkworm antibody
- Principal Investigator
  
  SASAKI SHIGERU
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
Molecular epidemiological elucidation of Japanese, American, and European gastric and colorectal carcinogenesis by integrated analysis of functional RNA and clinical application and cancer preventionPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Hiroyuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cancer epidemiology and prevention
- Research Institution
  St. Marianna University School of Medicine
  Sapporo Medical University
Analysis of the abnormalities of microRNA and epigenome and the clinical application in gastroenterological cancers
- Principal Investigator
  
  SHINOMURA Yasuhisa
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
Development of endoscopic molecular imaging diagnostic procedure for esophageal cancer using real-time virtual molecular biologyPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Hiroyuki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor diagnosis
- Research Institution
  Sapporo Medical University
Establishment of a treatment for advanced hepatocellular carcinoma using a tri-functional specific antibody
- Principal Investigator
  
  SASAKI Shigeru
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
Analysis and risk assessment of diffuse gastric cancer based on inflammation-induced epigenetic alterations
- Principal Investigator
  
  SHINOMURA Yasuhisa
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
消化管間質腫瘍におけるマイクロRNA発現異常の解明
- Principal Investigator
  
  篠村恭久
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
Mechanism of development and progression of gastrointestinal cancer by analysis of insulirrlike growth factor system and extracelluar matrix degrading enzymesPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Hiroyuki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
Development of diagnostic methods of gastrointestinal cancer using integrated analysis of nuclear molecules
- Principal Investigator
  
  SHINOMURA Yasuhisa
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
Molecular mechanisms of epigenetic alterations in gastrointestinal cancer and application to diagnosis and therapy
- Principal Investigator
  
  IMAI Kohzoh
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
進行肝癌に対するインターフェロン,抗FGFR-1ヒト抗体併用療法
- Principal Investigator
  
  SASAKI Shigeru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
Analysis of roles of alterations in non-coding region of genes in carcinogenesis with microsatellite instabilityPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Hiroyuki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
Analysis of gene expression in GIST by cDNA array
- Principal Investigator
  
  ITOH Fumio
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  ST.MARIANNA UNIVERSITY SCHOOL OF MEDICINE
Effect of proton pump inhibitor and COX2 inbitor upon Barrett's intestinal metaplasia.
- Principal Investigator
  
  ENDO Takao
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  First department of internal medicine, Sapporo Medical University
The anticancer effects of 5-aza-2'deoxycytidine as a DNA demethylation agent on NNK-induced rat hepatocellular carcimonas
- Principal Investigator
  
  SASAKI Shigeru
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
インスリン様増殖因子系を標的とする消化器癌の発癌進展機構の解明と遺伝子治療Principal Investigator
- Principal Investigator
  
  山本博幸
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
Application of DNA methylation analysis to tretment of gastrointestinal cancer.
- Principal Investigator
  
  YOSHIDA Yukinari
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
遺伝子不安定性癌における標的遺伝子変異に対する免疫応答の分子疫学的検索Principal Investigator
- Principal Investigator
  
  山本博幸
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Sapporo Medical University
Hox遺伝子群のメチル化異常と胃・大腸における発生部位特異的発癌・進展機構の解明Principal Investigator
- Principal Investigator
  
  山本博幸
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
Comparison between Barren's intestinal metaplasia and gastric intestinal metaplasia
- Principal Investigator
  
  ENDO Takao
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
Promoter region hypermethylation of cell cycle related gene in hepatocarcinogenesis
- Principal Investigator
  
  SASAKI Shigeru
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
Microsatellite instability and aberrant methylation in gastrointestinal cancer and its application to molecular target therapy
- Principal Investigator
  
  IMAI Kohzoh
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University
Immunelogical diagnosis of MSI-positive gastrointestinal cancer and application for cancer vaccine
- Principal Investigator
  
  IMAI Kohzoh
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Sapporo Medical University

[Book] The role and clinical implication of DNA methylation in gastrointestinal cancer. Recent Advances in Gastrointestinal Carcinogenesis.2006
- Author(s)
  Toyota M, Suzuki H, Maruyama R, Tarasawa I, Yamamoto E, Tokino T, Imai K, Shinomura Y
- Publisher
  Edited by Bamba H and Ota S, Transworld Research Network, Kerala, India
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Updates in the Field of Submucosal Endoscopy2022
- Author(s)
  Maehata Tadateru、Sato Yoshinori、Nakamoto Yusuke、Kato Masaki、Kawashima Akiyo、Kiyokawa Hirofumi、Yasuda Hiroshi、Yamamoto Hiroyuki、Tateishi Keisuke
- Journal Title
  
  Life
  
  Volume: 13 Issue: 1 Pages: 104-104
- DOI
  10.3390/life13010104
- Data Source
  KAKENHI-PROJECT-20K07812
[Journal Article] Risk factors of interventional radiology/surgery for colonic diverticular bleeding2021
- Author(s)
  Sato Yoshinori、Yasuda Hiroshi、Nakamoto Yusuke、Kiyokawa Hirofumi、Yamashita Masaki、Matsuo Yasumasa、Maehata Tadateru、Yamamoto Hiroyuki、Mimura Hidefumi、Itoh Fumio
- Journal Title
  
  JGH Open
  
  Volume: 5 Issue: 3 Pages: 343-349
- DOI
  10.1002/jgh3.12499
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07812
[Journal Article] Tip-in endoscopic mucosal resection for large colorectal sessile polyps2020
- Author(s)
  Sato Yoshinori、Ozawa Shun-ichiro、Yasuda Hiroshi、Kato Masaki、Kiyokawa Hirofumi、Yamashita Masaki、Matsuo Yasumasa、Yamamoto Hiroyuki、Itoh Fumio
- Journal Title
  
  Surgical Endoscopy
  
  Volume: 35 Issue: 4 Pages: 1820-1826
- DOI
  10.1007/s00464-020-07581-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07812
[Journal Article] GNAS-mutated carcinoma arising from gastric foveolar metaplasia in the duodenum after 9 years of observation.2018
- Author(s)
  Matsuo Y, Yamamoto H, Sato Y, Oikawa R, Maehata T, Fujino T, Yahagi N, Yasuda H, Takagi M, Itoh F.
- Journal Title
  
  Clin J Gastroenterol
  
  Volume: 11 Issue: 5 Pages: 391-395
- DOI
  10.1007/s12328-018-0856-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15435
[Journal Article] Endoscopic small-capacity forceps increase the pathological diagnosis of gastric indefinite neoplasia.2018
- Author(s)
  Matsuo Y, Yasuda H, Kato M, Kiyokawa H, Ozawa M, Sato Y, Ikeda Y, Ozawa SI, Yamashita M, Fujino T, Yamamoto H, Takagi M, Itoh F.
- Journal Title
  
  Turk J Gastroenterol
  
  Volume: 29 Issue: 4 Pages: 481-487
- DOI
  10.5152/tjg.2018.17347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15435
[Journal Article] Rebamipide solution: a novel submucosal injection material to promote healing speed and healing quality of ulcers induced by endoscopic submucosal dissection.2018
- Author(s)
  Fujimoto A, Uraoka T, Nishizawa T, Shimoda M, Goto O, Ochiai Y, Maehata T, Akimoto T, Mitsunaga Y, Sasaki M, Yamamoto H, Yahagi N.
- Journal Title
  
  Gastointest Endosc
  
  Volume: 87 Issue: 4 Pages: 1114-1120
- DOI
  10.1016/j.gie.2017.09.040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15435
[Journal Article] Impact of resistance-associated variant dominancy on treatment in patients with HCV genotype 1b receiving daclatasvir/asunaprevir.2017
- Author(s)
  Ikeda H, Watanabe T, Okuse C, Matsumoto N, Ishii T, Yamada N, Shigefuku R, Hattori N, Matsunaga K, Nakano H, Hiraishi T, Kobayashi M, Yasuda K, Yamamoto H, Yasuda H, Kurosaki M, Izumi N, Yotsuyanagi H, Suzuki M, Itoh F.
- Journal Title
  
  J Medical Virology
  
  Volume: 89 Issue: 1 Pages: 99-105
- DOI
  10.1002/jmv.24608
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08655
[Journal Article] Serum monomeric laminin-γ2 as a novel biomarker for hepatocellular carcinoma.2017
- Author(s)
  Kiyokawa H, Yasuda H, Oikawa R, Okuse C, Matsumoto N, Ikeda H, Watanabe T, Yamamoto H, Itoh F, Otsubo T, Yoshimura T, Yoshida E, Nakagawa M, Koshikawa N, Seiki M.
- Journal Title
  
  Cancer Science
  
  Volume: 108 Issue: 7 Pages: 1432-1439
- DOI
  10.1111/cas.13261
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08655, KAKENHI-PROJECT-17K09027, KAKENHI-PLANNED-17H06329
[Journal Article] Successful endoscopic fragmentation of large hardened fecaloma using jumbo forceps.2017
- Author(s)
  Matsuo Y, Yasuda H, Nakano H, Hattori M, Ozawa M, Sato Y, Ikeda Y, Ozawa SI, Yamashita M, Yamamoto H, Itoh F.
- Journal Title
  
  World J Gastrointest Endosc.
  
  Volume: 9 Issue: 2 Pages: 91-94
- DOI
  10.4253/wjge.v9.i2.91
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08655
[Journal Article] Identification of human papillomavirus (HPV) 16 DNA integration and the ensuing patterns of methylation in HPV-associated head and neck squamous cell carcinoma cell lines.2017
- Author(s)
  Takashi Hatano, Daisuke Sano, Hideaki Takahashi, Hiroshi Hyakusoku, Yasuhiro Isono, Shoko Shimada, Kae Sawakuma, Kentaro Takada, Ritsuko Oikawa, Yoshiyuki Watanabe, Hiroyuki Yamamoto, Fumio Itoh, Jeffrey N. Myers, Nobuhiko Oridate
- Journal Title
  
  Internal Journal of Cancer
  
  Volume: 140(7) Issue: 7 Pages: 1571-1580
- DOI
  10.1002/ijc.30589
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09295, KAKENHI-PROJECT-16K11240
[Journal Article] Enrichment of Helicobacter pylori mutant strains after eradication therapy analyzed by gastric wash-based quantitative pyrosequencing2017
- Author(s)
  Oikawa Ritsuko、Watanabe Yoshiyuki、Miyamoto Shuichi、Sato Yoshinori、Ono Shoko、Mabe Katsuhiro、Yamamoto Hiroyuki、Kato Mototsugu、Itoh Fumio
- Journal Title
  
  Tumour Biology
  
  Volume: 39 Issue: 10 Pages: 101042831773486-101042831773486
- DOI
  10.1177/1010428317734865
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09295
[Journal Article] Analysis of Helicobacter pylori genotypes in clinical gastric wash samples.2016
- Author(s)
  Miyamoto S, Watanabe Y, Oikawa R, Ono S, Mabe K, Kudo T, Yamamoto H, Itoh F, Kato M, Sakamoto N.
- Journal Title
  
  Tumour Biology
  
  Volume: Jan 29. Issue: 8 Pages: 1-10
- DOI
  10.1007/s13277-016-4886-4
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460937, KAKENHI-PROJECT-16K09295
[Journal Article] BARHL2 Methylation Using Gastric Wash DNA or Gastric Juice Exosomal DNA is a Useful Marker For Early Detection of Gastric Cancer in an H. pylori-Independent Manner.2016
- Author(s)
  Hiroyuki Yamamoto, Yoshiyuki Watanabe, Ritsuko Oikawa, Ryo Morita, Yoshihito Yoshida, Tadateru Maehata, Hiroshi Yasuda, Fumio Itoh
- Journal Title
  
  Clinical Translational Gastroenterology
  
  Volume: 7 Issue: 7 Pages: e184-e184
- DOI
  10.1038/ctg.2016.40
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09295
[Journal Article] Can the Abbott RealTime hepatitis C virus assay be used to predict therapeutic outcomes in hepatitis C virus-infected patients undergoing triple therapy?2016
- Author(s)
  Ikeda H, Okuse C, Watanabe T, Matsumoto N, Matsunaga K, Shigefuku R, Hattori N, Hiraishi T, Fukuda Y, Noguchi Y, Ishii T, Shima J, Nakahara K, Yamamoto H, Yasuda H, Yotsuyanagi H, Koike K, Itoh F, Suzuki M.
- Journal Title
  
  Turk J Gastroenterol.
  
  Volume: 27 Issue: 2 Pages: 165-172
- DOI
  10.5152/tjg.2016.150300
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08655
[Journal Article] Hemostasis Achieved Endoscopically for Diverticular Bleeding from the Horizontal Portion of the Duodenum.2015
- Author(s)
  Matsuo Y, Yasuda H, Suzuki M, Ishigooka S, Ozawa S, Yamashita M, Yamamoto H, Itoh F.
- Journal Title
  
  Clin Med Insights Gastroenterol
  
  Volume: 8 Pages: 61-64
- DOI
  10.4137/cgast.s32421
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08655
[Journal Article] Urgent Computed Tomography for Determining the Optimal Timing of Colonoscopy in Patients with Acute Lower Gastrointestinal Bleeding2015
- Author(s)
  Nakatsu S, Yasuda H, Maehata T, Nomoto M, Ohinata N, Hosoya K, Ishigooka E, Ozawa S, Ikeda Y, Sato Y, Suzuki M, Kiyokawa H, Yamamoto H, Itoh F.
- Journal Title
  
  Intern. Med.
  
  Volume: 54 Issue: 6 Pages: 553-558
- DOI
  10.2169/internalmedicine.54.2829
- NAID
  130004903081
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08655
[Journal Article] Treatment and prevention of gastrointestinal bleeding in patients receiving antiplatelet therapy.2015
- Author(s)
  Yasuda H, Matsuo Y, Sato Y, Ozawa S, Ishigooka S, Yamashita M, Yamamoto H, Itoh F.
- Journal Title
  
  World J Critical Care Medicine
  
  Volume: 4 Issue: 1 Pages: 40-47
- DOI
  10.5492/wjccm.v4.i1.40
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08655
[Journal Article] HER2 Expression and PI3K-Akt Pathway Alterations in Gastric Cancer2014
- Author(s)
  Sukawa Y, Yamamoto H, Nosho K, Ito M, Igarashi H, Naito T, Mitsuhashi K, Matsunaga Y, Takahashi T, Mikami M, Adachi Y, Suzuki H, Shinomura Y.
- Journal Title
  
  Digestion
  
  Volume: 89 Pages: 12-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390200
[Journal Article] The effect of IGF-I receptor blockade for human esophageal squamous cell carcinoma and adenocarcinoma2014
- Author(s)
  Adachi Y, Ohashi H, Imsumran A, Yamamoto H, Matsunaga Y, Taniguchi H, Nosho K, Suzuki H, Sasaki Y, Arimura Y, Carbone DP, Imai K, Shinomura Y
- Journal Title
  
  Tumour Biol
  
  Volume: 35 Issue: 2 Pages: 973-985
- DOI
  10.1007/s13277-013-1131-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-23390200, KAKENHI-PROJECT-23590920, KAKENHI-PROJECT-24650632, KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-221S0001
[Journal Article] The effect of IGF-I receptor blockade for human esophageal squamous cell carcinoma and adenocarcinoma2014
- Author(s)
  Adachi Y, Ohashi H, Imsumran A, Yamamoto H, Matsunaga Y, Taniguchi H, Nosho K, Suzuki H, Sasaki Y, Arimura Y, Carbone DP, Imai K, Shinomura Y.
- Journal Title
  
  Tumour Biol.
  
  Volume: 35 Pages: 973-985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390200
[Journal Article] Association of microRNA-31 with BRAF mutation, colorectal cancer survival and serrated pathway2014
- Author(s)
  Nosho K, Igarashi H, Nojima M, Ito M, Maruyama R, Yoshii S, Naito T, Sukawa Y, Mikami M, Sumioka W, Yamamoto E, Kurokawa S, Adachi Y, Takahashi H, Okuda H, Kusumi T, Hosokawa M, Fujita M, Hasegawa T, Okita K, Hirata K, Suzuki H, Yamamoto H, Shinomura Y.
- Journal Title
  
  Carcinogenesis
  
  Volume: 35 Pages: 776-783
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390200
[Journal Article] Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk2014
- Author(s)
  Suzuki R, Yamamoto E, Nojima M, Maruyama R, Yamano HO, Yoshikawa K, Kimura T, Harada T, Ashida M, Niinuma T, Sato A, Nosho K, Yamamoto H, Kai M, Sugai T, Imai K, Suzuki H, Shinomura Y. et al.
- Journal Title
  
  J Gastroenterol
  
  Volume: 49 Pages: 1135-1144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390200
[Journal Article] An updated review of gastric cancer in the next-generation sequencing era: Insights from bench to bedside and vice versa2014
- Author(s)
  Yamamoto H, Watanabe Y, Maehata T, Morita R, Yoshida Y, Oikawa R, Ishigooka S, Ozawa SI, Matsuo Y, Hosoya K, Yamashita M, Taniguchi H, Nosho K, Suzuki H, Yasuda H, Shinomura Y, Itoh F
- Journal Title
  
  World J Gastroenterol
  
  Volume: 20 Pages: 3927-3937
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300366
[Journal Article] Association of microRNA-31 with BRAF mutation, colorectal cancer survival, and serrated pathway2014
- Author(s)
  Nosho K (他18名), Igarashi H, Ito M, Nojima M, Yamamoto H, Shinomura Y
- Journal Title
  
  Carcinogenesis
  
  Volume: 35 Issue: 4 Pages: 776-783
- DOI
  10.1093/carcin/bgt374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-25461705, KAKENHI-PROJECT-25670371
[Journal Article] MicroRNA-31 expression in relation to BRAF mutation, CpG island methylation and colorectal continuum in serrated lesions2014
- Author(s)
  Ito M, Mitsuhashi K, Igarashi H, Nosho K, Yamamoto H
- Journal Title
  
  Int J Cancer
  
  Volume: (Epub ahead of print) Issue: 11 Pages: 2507-2515
- DOI
  10.1002/ijc.28920
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23590920, KAKENHI-PUBLICLY-25134715, KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-25461705, KAKENHI-PROJECT-26460944, KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-221S0001
[Journal Article] HER2 expression and PI3K-Akt pathway alterations in gastric cancer2014
- Author(s)
  Sukawa Y, Yamamoto H (他9名), Nosho K, Shinomura Y
- Journal Title
  
  Digestion
  
  Volume: 89 Issue: 1 Pages: 12-17
- DOI
  10.1159/000356201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300366
[Journal Article] Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk2014
- Author(s)
  Suzuki R, Yamamoto E, Nojima M, Maruyama R, Yamano HO, Yoshikawa K, Kimura T, Harada T, Ashida M, Niinuma T, Sato A, Nosho K, Yamamoto H, Kai M, Sugai T, Imai K, Suzuki H, Shinomura Y
- Journal Title
  
  J Gastroenterol
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300366
[Journal Article] Factors associated with risk for colorectal cancer recurrence after endoscopic resection of T1 tumors2014
- Author(s)
  Yoshii S, Nojima M, Nosho K, Omori S, Kusumi T, Okuda H, Tsukagoshi H, Fujita M, Yamamoto H, Hosokawa M
- Journal Title
  
  Clin Gastroenterol Hepatol
  
  Volume: 12 Issue: 2 Pages: 292-302
- DOI
  10.1016/j.cgh.2013.08.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300366
[Journal Article] An updated review of gastric cancer in the next-generation sequencing era : Insights from bench to bedside and vice versa2014
- Author(s)
  Yamamoto H (他14名), Nosho K, Shinomura Y
- Journal Title
  
  World J Gastroenterol
  
  Volume: 20 Issue: 14 Pages: 3927-3937
- DOI
  10.3748/wjg.v20.i14.3927
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23590928, KAKENHI-PROJECT-25460937, KAKENHI-PROJECT-25670371
[Journal Article] Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk2013
- Author(s)
  Suzuki R, Nosho K (他14名), Yamamoto H, Shinomura Y
- Journal Title
  
  J Gastroenterol
  
  Volume: (Epub ahead of print) Issue: 7 Pages: 1135-1144
- DOI
  10.1007/s00535-013-0861-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23791283, KAKENHI-PROJECT-25460420, KAKENHI-PROJECT-25461705, KAKENHI-PROJECT-25670371, KAKENHI-PROJECT-25830103, KAKENHI-PROJECT-25860547, KAKENHI-PROJECT-25860548
[Journal Article] Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk2013
- Author(s)
  Suzuki R, Yamamoto E, Nojima M, Maruyama R, Yamano HO, Yoshikawa K, Kimura T, Harada T, Ashida M, Niinuma T, Sato A, Nosho K, Yamamoto H, Kai M, Sugai T, Imai K, Suzuki H, Shinomura Y.
- Journal Title
  
  J Gastroenterol
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390200
[Journal Article] Brush border myosin Ia inactivation in gastric but not endometrial tumors2013
- Author(s)
  Mazzolini R1, Rodrigues P, Bazzocco S, Dopeso H, Ferreira AM, Mateo-Lozano S, Andretta E, Woerner SM, Alazzouzi H, Landolfi S, Hernandez-Losa J, Macaya I, Suzuki H, Ramon y Cajal S, Mooseker MS, Mariadason JM, Gebert J, Hofstra RM, Reventos J, Yamamoto H, Schwartz S Jr, Arango D
- Journal Title
  
  Int J Cancer
  
  Volume: 132 Issue: 8 Pages: 1790-1799
- DOI
  10.1002/ijc.27856
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300366
[Journal Article] Association between genomic alterations and metastatic behavior of colorectal cancer identified by array-based comparative genomic hybridization.2013
- Author(s)
  Sawada T, Yamamoto E, Suzuki H
- Journal Title
  
  Genes Chromosomes Cancer
  
  Volume: 52(2) Issue: 2 Pages: 140-9
- DOI
  10.1002/gcc.22013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590317, KAKENHI-PROJECT-22790655, KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-24650632, KAKENHI-PROJECT-25460420, KAKENHI-PROJECT-221S0001
[Journal Article] Alterations in the human epidermal growth factor receptor 2-phosphatidylinositol 3-kinase-v-Akt pathway in gastric cancer2012
- Author(s)
  Sukawa Y, Yamamoto H (他11名), Nosho K, Shinomura Y
- Journal Title
  
  World J Gastroenterol
  
  Volume: 18 Issue: 45 Pages: 6577-6586
- DOI
  10.3748/wjg.v18.i45.6577
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23390200, KAKENHI-PROJECT-23659400, KAKENHI-PROJECT-23790800
[Journal Article] Aberrant Methylation of RASGRF1 Is Associated with an Epigenetic Field Defect and Increased Risk of Gastric Cancer.2012
- Author(s)
  Takamaru H, Yamamoto E, Suzuki H.
- Journal Title
  
  Cancer Prev Res (Phila)
  
  Volume: 5(10) Issue: 10 Pages: 2012-2012
- DOI
  10.1158/1940-6207.capr-12-0056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590317, KAKENHI-PROJECT-22790655, KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23390200, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23659400, KAKENHI-PROJECT-23659658, KAKENHI-PROJECT-24650632
[Journal Article] IGF-I receptor expression is associated with aggressive phenotypes and has therapeutic activity in biliary tract cancers2012
- Author(s)
  Ohashi H, Adachi Y, Yamamoto H, Taniguchi H, Nosho K, Suzuki H, Arimura Y, Imai K, Carbone DP, Shinomura Y.
- Journal Title
  
  Cancer Sci.
  
  Volume: 103 Pages: 252-261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390200
[Journal Article] Interrelationship between microsatellite instability and microRNA in gastrointestinal cancer.2012
- Author(s)
  Yamamoto H, Adachi Y, Taniguchi H, Kunimoto H, Nosho K, Suzuki H, Shinomura Y.
- Journal Title
  
  World J Gastroenterol.
  
  Volume: 18 Pages: 2745-2755
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390200
[Journal Article] Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors2012
- Author(s)
  Takeshi Niinuma
- Journal Title
  
  Cancer research
  
  Volume: 72 Issue: 5 Pages: 1126-36
- DOI
  10.1158/0008-5472.can-11-1803
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790655, KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23390200, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23659400, KAKENHI-PROJECT-23659658, KAKENHI-PROJECT-24650632
[Journal Article] Emerging links between epigenetic alterations and dysregulation of noncoding RNAs in cancer.2012
- Author(s)
  Maruyama R, Suzuki H, Yamamoto E, Imai K, Shinomura Y.
- Journal Title
  
  Tumour Biol.
  
  Volume: 33 Pages: 275-285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390200
[Journal Article] Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors2012
- Author(s)
  Niinuma T, Suzuki H, Nojima M, Nosho K, Yamamoto H, Takamaru H, Yamamoto E, Maruyama R, Nobuoka T, Miyazaki Y, Nishida T, Bamba T, Kanda T, Ajioka Y, Taguchi T, Okahara S, Takahashi H, Nishida Y, Hosokawa M, Hasegawa T, Tokino T, Hirata K, Imai K, Toyota M, Shinomura Y.
- Journal Title
  
  Cancer Res.
  
  Volume: 72 Pages: 1126-1136
- NAID
  10031131121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390200
[Journal Article] Alterations in the HER2-PI3K-Akt pathway in gastric cancer2012
- Author(s)
  Sukawa Y, Yamamoto H, Nosho K, Kunimoto H, Suzuki H, Adachi Y, Nakazawa M, Nobuoka T, Kawayama M, Mikami M, Matuno T, Hasegawa T, Hirata K, Imai K, Shinomura Y.
- Journal Title
  
  World J Gastroenterol
  
  Volume: 18 Pages: 6577-6586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390200
[Journal Article] Interrelationship between microsatellite instability and microRNA in gastrointestinal cancer2012
- Author(s)
  Yamamoto H, Adachi Y, Taniguchi H, Kunimoto H, Nosho K, Suzuki H, Shinomura Y
- Journal Title
  
  World J Gastroenterol
  
  Volume: 18 Issue: 22 Pages: 2745-2755
- DOI
  10.3748/wjg.v18.i22.2745
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23390200
[Journal Article] Molecular Dissection of Premalignant Colorectal Lesions Reveals Early Onset of the CpG Island Methylator Phenotype.2012
- Author(s)
  Yamamoto E, Suzuki H, Yamano HO
- Journal Title
  
  Am J Pathol
  
  Volume: 181(5) Issue: 5 Pages: 1847-61
- DOI
  10.1016/j.ajpath.2012.08.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590317, KAKENHI-PROJECT-22790655, KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-23390200, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23590920, KAKENHI-PROJECT-23659658, KAKENHI-PROJECT-23791283, KAKENHI-PROJECT-24650632
[Journal Article] Interferon-α/βand anti-fibroblast growth factor receptor 1 monoclonal antibody suppress hepatic cancer cells in vitro and in vivo2011
- Author(s)
  Sasaki S, Ishida T, Toyota M, Ota A, Suzuki H, Takaoka A, Yasui H, Yamamoto H, Takagi H, Maeda M, Seito T, Tsujisaki M, Shinomura Y, Imai K
- Journal Title
  
  PLoS One
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590853
[Journal Article] Epigenetic inactivation of calcium-sensing receptor in colorectal carcinogenesis.2011
- Author(s)
  Hizaki K, Yamamoto H, Taniguchi H, Adachi Y, Nakazawa M, Tanuma T, Kato N, Sukawa Y, Sanchez JV, Suzuki H, Sasaki S, Imai K, Shinomura Y.
- Journal Title
  
  Mod Pathol
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] Role of DNA Methylation in the Development of Diffuse-Type Gastric Cancer.2011
- Author(s)
  Yamamoto E, et al.
- Journal Title
  
  Digestion
  
  Volume: 83 Pages: 241-249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] Role of DNA Methylation in the Development of Diffuse-Type Gastric Cancer.2011
- Author(s)
  Yamamoto E, Suzuki H, Takamaru H, Yamamoto H, Toyota M, Shinomura Y.
- Journal Title
  
  Digestion 83
  
  Pages: 241-249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] A DNA methylation fingerprint of 1628 human samples2011
- Author(s)
  Fernandez AF, Assenov Y, Martin-Subero JI, Balint B, Siebert R, Taniguchi H, Yamamoto H, Hidalgo M, Tan AC, Galm O, Ferrer I, Sanchez-Cespedes M, Villanueva A, Carmona J, Sanchez-Mut JV, Berdasco M, Moreno V, Capella G, Monk D, Ballestar E, Ropero S, Martinez R, Sanchez-Carbayo M, Prosper F, Agirre X, Fraga MF, Grana O, Perez-Jurado L, Mora J, Puig S, Prat J, Badimon L, Puca AA, Meltzer SJ, Lengauer T, Bridgewater J, Bock C, Esteller M
- Journal Title
  
  Genome Res
  
  Volume: 22(2) Issue: 2 Pages: 407-19
- DOI
  10.1101/gr.119867.110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23701063, KAKENHI-PROJECT-24650632
[Journal Article] Profiling of chromatin signatures reveals epigenetic regulation of microRNA genes in colorectal cancer2011
- Author(s)
  Suzuki H, Takatsuka S, Akashi H, Yamamoto E, Nojima M, Maruyama R, Kai M, Yamano H, Sasaki Y, Tokino T, Shinomura Y, Imai K, Toyota M.
- Journal Title
  
  Cancer Res.
  
  Volume: 71 Pages: 5646-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390200
[Journal Article] A candidate targeting molecule of insulin-like growth factor-I receptor for gastrointestinal cancers.2010
- Author(s)
  Adachi Y, Yamamoto H, Ohashi H, Endo T, Carbone DP, Imai K, Shinomura Y.
- Journal Title
  
  World J Gastroenterol 16
  
  Pages: 5779-5789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype.2010
- Author(s)
  Suzuki H, Igarashi S, Nojima M, Maruyama R, Yamamoto E, Kai M, Akashi H, Watanabe Y, Yamamoto H, Sasaki Y, Itoh F, Imai K, Sugai T, Shen L, Issa JP, Shinomura Y, Tokino T, Toyota M.
- Journal Title
  
  Carcinogenesis 31
  
  Pages: 342-349
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] Methylation-associated silencing of microRNA-34b/c in gastric cancer and its involvement in an epigenetic field defect.2010
- Author(s)
  Suzuki H, Yamamoto E, Nojima M, Kai M, Yamano HO, Yoshikawa K, Kimura T, Kudo T, Harada E, Sugai T, Takamaru H, Niinuma T, Maruyama R, Yamamoto H, Tokino T, Imai K, Toyota M, Shinomura Y.
- Journal Title
  
  Carcinogenesis 31
  
  Pages: 2066-2073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] A novel correlation between LINE-1 hypomethylation and the malignancy of gastrointestinal stromal tumors.2010
- Author(s)
  Igarashi S, Suzuki H, Niinuma T, Shimizu H, Nojima M, Iwaki H, Nobuoka T, Nishida T, Miyazaki Y, Takamaru H, Yamamoto E, Yamamoto H, Tokino T, Hasegawa T, Hirata K, Imai K, Toyota M, Shinomura Y.
- Journal Title
  
  Clin Cancer Res 16
  
  Pages: 5114-5123
- NAID
  130004927691
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells.2010
- Author(s)
  Melo SA, Moutinho C, Ropero S, Calin GA, Rossi S, Spizzo R, Fernandez AF, Davalos V, Villanueva A, Montoya G, Yamamoto H, Schwartz S, Jr., Esteller M.
- Journal Title
  
  Cancer Cell 18
  
  Pages: 303-315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] Targeting for insulin-like growth factor-I receptor with short hairpin RNA for human digestive/gastrointestinal cancers.2010
- Author(s)
  Wang Y, Adachi Y, Imsumran A, Yamamoto H, Piao W, Li H, Ii M, Arimura Y, Park MY, Kim D, Lee CT, Carbone DP, Imai K, Shinomura Y.
- Journal Title
  
  J Gastroenterol 45
  
  Pages: 159-170
- NAID
  10027214385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] IGFBP7 is p53 responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype.2010
- Author(s)
  Suzuki H, Igarashi S, Nojima M, Maruyama R, Yamamoto E, Kai M, Akashi H, Watanabe Y, Yamamoto H, Sasaki Y, Itoh F, Imai K, Sugai T, Shen L, Issa JPJ, Shinomura Y, Tokino T, Toyota M
- Journal Title
  
  Carcinogenesis 31
  
  Pages: 342-349
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Epigenetic inactivation of the circadian clock gene BMAL1 in hematological malignancies.2009
- Author(s)
  Taniguchi H, Fernandez AF, Setien F, Ropero S, Ballestar E, Villanueva A, Yamamoto H, Imai K, Shinomura Y, Esteller M
- Journal Title
  
  Cancer Res 69
  
  Pages: 8447-8454
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Enhancing epithelial engraftment of rat mesenchymal stem cells restores epithelial barrier integrity.2009
- Author(s)
  Yabana T, Arimura Y, Tanaka H, Goto A, Hosokawa M, Nagaishi K, Yamashita K, Yamamoto H, Adachi Y, Sasaki Y, Isobe M, Fujimiya M, Imai K, Shinomura Y.
- Journal Title
  
  J Pathol 218
  
  Pages: 350-359
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] Integrated analysis of genetic and epigenetic alterations in cancer.2009
- Author(s)
  Toyota M, Suzuki H, Yamamoto E, Yamano H, Imai K, Shinomura Y
- Journal Title
  
  Epigenomics 1
  
  Pages: 291-299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Overexpression of beta3/gamma2 chains of laminin-5 and MMP7 in biliary cancer.2009
- Author(s)
  Oka T, Yamamoto H, Sasaki S, Ii M, Hizaki K, Taniguchi H, Adachi Y, Imai K, Shinomura Y.
- Journal Title
  
  World J Gastroenterol 15
  
  Pages: 3865-3873
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function.2009
- Author(s)
  Melo SA, Ropero S, Moutinho C, Aaltonen LA, Yamamoto H, Calin GA, Rossi S, Fernandez AF, Carneiro F, Oliveira C, Ferreira B, Liu CG, Villanueva A, Capella G, Schwartz S, Jr., Shiekhattar R, Esteller M.
- Journal Title
  
  Nat Genet 41
  
  Pages: 365-470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies.2009
- Author(s)
  Taniguchi H, Fernandez AF, Setien F, Ropero S, Ballestar E, Villanueva A, Yamamoto H, Imai K, Shinomura Y, Esteller M.
- Journal Title
  
  Cancer Res 69
  
  Pages: 8447-8454
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] Genetic and epigenetic characteristics of gastric cancers with JC virus T-antigen.2009
- Author(s)
  Yamaoka S, Yamamoto H, Nosho K, Taniguchi H, Adachi Y, Sasaki S, Arimura Y, Imai K, Shinomura Y.
- Journal Title
  
  World J Gastroenterol 15
  
  Pages: 5579-5585
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma.2008
- Author(s)
  Takagi H, Sasaki S, Suzuki H, Toyota M, Maruyama R, Nojima M, Yamamoto H, Omata M, Tokino T, Imai K, Shinomura Y.
- Journal Title
  
  J Gastroenterol 43
  
  Pages: 378-389
- NAID
  10021268741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged fold gastritis.2008
- Author(s)
  Yamamoto E., et al.
- Journal Title
  
  Cancer Epidemiol. Biomarker. Prev. 17
  
  Pages: 2555-2564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659188
[Journal Article] Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer.2008
- Author(s)
  Maruyama R, Akino K, Toyota M, Suzuki H, Imai T, Ohe-Toyota M, Yamamoto E, Nojima M, Fujikane T, Sasaki Y, Yamashita T, Watanabe Y, Hiratsuka Y, Hirata K, Itoh F, Imai K, Shinomura Y, Tokino T
- Journal Title
  
  Carcinogenesis 29
  
  Pages: 1312-1318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold gastritis.2008
- Author(s)
  Yamamoto E, Toyota M, Suzuki H, Kondo Y, Sanomura T, Murayama Y, Ohe-Toyota M, Maruyama R, Nojima M, Ashida M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y.
- Journal Title
  
  Cancer Epidemiol Biomarkers Prev 17
  
  Pages: 2555-2564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma.2008
- Author(s)
  Takagi H, Sasaki S, Suzuki H, Toyota M, Maruyama R, Nojima M, Yamamoto H, Omata M, Tokino T, Imai K, Shinomura Y
- Journal Title
  
  J. Gastroenterol 43
  
  Pages: 378-389
- NAID
  10021268741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] LINE-1 hypomethylation is associated with increased CpG island methylation in helicobactor pylori-related enlarged fold gastritis.2008
- Author(s)
  Yamamoto E, Toyota M, Suzuki H, Kondo Y, Imai K, Sanomura T, Murayama Y, Ohe-Toyota M, Maruyama R, Nojima M, Ashida M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y
- Journal Title
  
  Cancer Epidemiol Biomarkers Prev 17
  
  Pages: 2555-2564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] LINE-1 hypomethylation is associated with increased CpG island methylation in helicobactor pylori-related enlarged fold gastritis.2008
- Author(s)
  Yamamoto E., et al.
- Journal Title
  
  Cancer Epidemiol. Biomarker. Prev. 17
  
  Pages: 2555-2564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer.2008
- Author(s)
  Maruyama R, Akino K, Toyota M, Suzuki H, Imai T, Ohe-Toyota M, Yamamoto E, Nojima M, Fujikane T, Sasaki Y, Yamashita T, Watanabe Y, Hiratsuka H, Hirata K, Itoh F, Imai K, Shinomura Y, Tokino T.
- Journal Title
  
  Carcinogenesis 29
  
  Pages: 1312-1318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] Correlation of laterally spreading type and JC virus with methylator phenotype status in colorectal adenoma.2008
- Author(s)
  Nosho K, Yamamoto H, Takahashi T, Mikami M, Hizaki K, Maehata T, Taniguchi H, Yamaoka S, Adachi Y, Itoh F, Imai K, Shinomura Y.
- Journal Title
  
  Hum Pathol 39
  
  Pages: 767-775
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers.2008
- Author(s)
  Oki M, Yamamoto H, Taniguchi H, Adachi Y, Imai K, Shinomura Y.
- Journal Title
  
  World J Gastroenterol 14
  
  Pages: 5650-5656
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390210
[Journal Article] LINE-1 hypomethylation is associated with increased CpG island methylation in helicobactor pylori-related enlarged fold gastritis.2008
- Author(s)
  Yamamoto E., et al.
- Journal Title
  
  Cancer Epidemiol. Biormarker. Prev. 17
  
  Pages: 2555-2564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer.2007
- Author(s)
  Akino K, Toyota M, Suzuki H, Imai T, Maruyama R, Kusano M, Nishikawa N, Watanabe Y, Sasaki Y, Abe T, Yamamoto E, Tarasawa I, Sonoda T, Mori M, Imai K, Shinomura Y, Tokino T
- Journal Title
  
  Cancer Sci 98
  
  Pages: 88-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Journal Article] A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition.2006
- Author(s)
  Ropero, S., Fraga, M., Ballestar, E., Hamelin, R., Yamamoto, H., Boix-Chornet, M., Caballero, R., Alaminos, M., Setien, F., Paz, M.F., Herranz, M., Palacios, J., Arango, D., Orntoft, T.F., Aaltonen, L.A., Schwartz, S.Jr., Esteller, M.
- Journal Title
  
  Nat.Genet. 41
  
  Pages: 566-569
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390213
[Journal Article] Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors.2005
- Author(s)
  Alazzouzi, H., Davalos, V., Kokko, A., Domingo, E., Woerner, S.M., Wilson, A.J., Imai, K., Yamamoto, H., Mariadason, J.M., Gebert, J.F., Aaltonen, L.A., Simo Schwartz, S.Jr., Arango, D.
- Journal Title
  
  Oncogene 24
  
  Pages: 7630-7634
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390213
[Journal Article] Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers.2005
- Author(s)
  Taniguchi, H., Yamamoto, H.(co-first), Hirata, T., Miyamoto, M., Oki, M., Nosho, K., Imsumran, A., Adachi, Y., Endo, T., Imai, K., Shinomura, Y.
- Journal Title
  
  Oncogene 24
  
  Pages: 7946-7952
- NAID
  130004927581
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390213
[Journal Article] BRAF-V600E is not involved in the colorectal tumorigenesis of HNPCC patients with functional MLH1 and MSH2 genes.2005
- Author(s)
  Domingo, E., Niessen, R.C., Oliveira, C., Alhopuro, P., Moutinho, C., Espin, E., Armengol, M., Sijmons, R.H., Kleibeuker, J.H., Seruca, R., Aaltonen, L.A., Imai, K., Yamamoto, H., Schwartz, S.Jr., Hofstra, R.M.W.
- Journal Title
  
  Oncogene 24
  
  Pages: 3995-3998
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390213
[Journal Article] Concomitant RASSF1A hypermethylation and KRAS/BRAF mutations occur preferentially in MSI sporadic colorectal cancer.2005
- Author(s)
  Oliveira, C., Velho, S., Domingo, E., Preto, A., Hofstra, R.M.W., Hamelin, R., Yamamoto, H., Seruca, R., Schwartz, S.Jr.
- Journal Title
  
  Cancer Res. 65
  
  Pages: 10170-10173
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390213
[Journal Article] Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation.2004
- Author(s)
  Domingo, E., Espin, E., Armengol, M., Oliveira, C., Pinto, M., Duval, A., Brennetot, C., Seruca, R., Hamelin, R., Yamamoto, H., Schwartz, S.Jr.
- Journal Title
  
  Genes Chromosomes Cancer 39
  
  Pages: 138-142
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390213
[Journal Article] Expression of ets-related transcriptional factor E1AF is associated with tumor progression and overexpression of matrilysin in human gastric cancer2004
- Author(s)
  Hiroyuki Yamamoto
- Journal Title
  
  Carcinogenesis 25
  
  Pages: 325-332
- Data Source
  KAKENHI-PROJECT-16390213
[Journal Article] Interplay of insulin-like growth factor-II, insulin-like growth factor-I, insulin-like growth factor-I receptor, COX-2, and matrix metalloproteinase-7, play key roles in the early stage of colorectal carcinogenesis2004
- Author(s)
  Nosho K, Yamamoto H, Taniguchi H, Adachi Y, Yoshida Y, Arimura Y, Endo T, Hinoda Y, Imai K
- Journal Title
  
  Clin Cancer Res 10
  
  Pages: 7950-7957
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590664
[Journal Article] Braf screening as a low-cost effective strategy for simplifying HNPCC genetic testing.2004
- Author(s)
  Domingo, E., Laiho, P., Ollikainen, M., Pinto, M., Wang, L., French, A.J., Westra, J., Frebourg, T., Espin, E., Armengol, M., Hamelin, R., Yamamoto, H., Hofstra, R.M.W., Seruca, R., Lindblom, A., Peltomaki, P., Thibodeau, S.N., Aaltonen, L.A., Schwartz, S.Jr.
- Journal Title
  
  J Med.Genet. 41
  
  Pages: 663-667
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390213
[Journal Article] Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status.2004
- Author(s)
  Oliveira, C., Westra, J.L., Arango, D., Ollikainen, M., Domingo, E., Ferreira, A., Velho, S., Niessen, R., Lagerstedt, K., Alhopuro, P., Laiho, P., Veiga, I., Teixeira, M.R., Ligtenberg, M., Kleibeuker, J.H., Sijmons, R.H., Plukker, J.T., Imai, K., Lage, P., Hamelin, R., Albuquerque, C., Schwartz, S.Jr., Lindblom, A., Peltomaki, P., Yamamoto, H., Aaltonen, L.A., Seruca, R., Hofstra, R.M.
- Journal Title
  
  Hum.Mol.Genet. 13
  
  Pages: 2303-2311
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390213
[Journal Article] Expression of ets-related transcriptional factor E1AF is associate with tumor progression and overexpression of matrilysin in human gastric cancer2004
- Author(s)
  Hiroyuki Yamamoto
- Journal Title
  
  Carcinogenesis 25
  
  Pages: 325-332
- Data Source
  KAKENHI-PROJECT-13220017
[Journal Article] Interplay of insulin-like growth factor-II, insulin-like growth factor-I, insulin-like growth factor-I receptor, COX-2, and matrix metalloproteinase-7, play key roles in the early stage of colorectal carcinogenesis.2004
- Author(s)
  Nosho K, Yamamoto H
- Journal Title
  
  Clin Cancer Res. 10
  
  Pages: 7950-7957
- Data Source
  KAKENHI-PROJECT-15590664
[Journal Article] The expression of matrix metalloproteinase matrilysin indicates the degree of inflammation in ulcerative colitis2003
- Author(s)
  Matsuno K, Adachi Y, Yamamoto H, Goto A, Arimura Y, Endo T, Itoh F, Imai K
- Journal Title
  
  J Gastroenterol 38
  
  Pages: 348-354
- NAID
  10012737385
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590664
[Journal Article] Differential roles of alterations of p53, p16, and SMAD4 expression in the progression of intraductal papillary-mutinous tumors of the pancreas2003
- Author(s)
  Sasaki S, Yamamoto H, Kaneto H, Ozeki I, Adachi Y, Takagi H, Matsumoto T, Itoh H, Nagakawa T, Miyakawa H, Muraoka S, Fujinaga A, Suga T, Satoh M, Itoh F, Endo T, Imai K
- Journal Title
  
  Oncol Rep 10
  
  Pages: 21-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590664
[Journal Article] Differential roles of alterations of p53, p16, and SMAD4 expression in the progression of intraductal papillary-mucinous tumors of the pancreas2003
- Author(s)
  Sasaki S, Yamamoto H, Kaneto H, Ozeki I, Adachi Y, Takagi H, Matsumoto T, Itoh H, Nagakawa T, Miyakawa H, Muraoka S, Fujinaga A, Suga T, Satoh M, Itoh F, Endo T, Imai K.
- Journal Title
  
  Oncol Rep. 10(1)
  
  Pages: 21-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590667
[Journal Article] ASSOCIATION OF TRYPSIN EXPRESSION WITH TUMOR PROGRESSION AND MATRILYSIN EXPRESSION IN HUMAN COLORECTAL CANCER.2003
- Author(s)
  YAMAMOTO H, IKU S, ITOH F, et al.
- Journal Title
  
  J PATHOL 199
  
  Pages: 176-184
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590663
[Journal Article] Differential involvement of the hypermethylator phenotype in hereditary and sporadic colorectal cancers with high-frequency microsatellite instability.2002
- Author(s)
  Yamamoto H et al.
- Journal Title
  
  Genes Chromosomes Cancer 33
  
  Pages: 322-325
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13854016
[Journal Article] Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human pancreatic adenocarcinomas : clinicopathologic and prognostic significance of matrilysin expression.2001
- Author(s)
  Yamamoto H et al.
- Journal Title
  
  J Clin Oncol 19
  
  Pages: 1118-1127
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13854016
[Journal Article] Genetic and clinical features of human pancreatic ductal adenocarcinomas with widespread microsatellite instability.2001
- Author(s)
  Yamamoto H et al.
- Journal Title
  
  Cancer Res 61
  
  Pages: 3139-3144
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13854016
[Journal Article] Genetic and clinical features of human pancreatic ductal adenocarcinomas with widespread microsatellite instability.2001
- Author(s)
  Yamamoto H et al.
- Journal Title
  
  Cancer Res, 61
  
  Pages: 3139-3144
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13854016
[Journal Article] Epigenetic inactivation of interferon regulatory factor genes in gastric cancer.
- Author(s)
  Yamashita M, Toyota M, Suzuki H, Nojima M, Yamamoto E, Kamimae S, Watanabe Y, Kai M, Akashi H, Maruyama R, Sasaki Y, Yamano H, Sugai T, Shinomura Y, Imai K, Tokino T, Itoh F
- Journal Title
  
  Cancer Sci (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109008
[Patent] 大腸癌を治療および／または診断するための組成物ならびにその利用2013
- Inventor(s)
  篠村　恭久, 能正勝彦, 山本博幸, 鈴木拓
- Industrial Property Rights Holder
  北海道公立大学法人　札幌医科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2013-06-14
- Data Source
  KAKENHI-PROJECT-23390200
[Patent] 腸癌を治療および/または診断するための組成物ならびにその利用2013
- Inventor(s)
  篠村恭久, 能正勝彦, 山本博幸, 鈴木拓
- Industrial Property Rights Holder
  北海道公立大学法人札幌医科大学
- Industrial Property Number
  2013-126021
- Filing Date
  2013-06-14
- Data Source
  KAKENHI-PROJECT-23390200
[Presentation] 胃洗浄廃液を用いたヒトとピロリ菌ゲノム解析に基づく胃全体の情報を網羅した胃癌のトランスレーショナルリサーチ2018
- Author(s)
  山本博幸
- Organizer
  日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-16K15435
[Presentation] Enrichment of Helicobacter pylori mutant strains after eradication therapy analyzed by gastric wash-based quantitative pyrosequencing and NGS.2018
- Author(s)
  Watanabe Y, Oikawa R, Yamamoto H, Itoh F.
- Organizer
  Digestive Disease Week 2018
- Data Source
  KAKENHI-PROJECT-16K15435
[Presentation] 胃洗浄廃液を用いた胃内H.pylori菌遺伝子NGS解析の診断・治療への応用2018
- Author(s)
  渡邊嘉行、山本博幸、伊東文生
- Organizer
  第14回　日本消化管学会総会学術集会
- Data Source
  KAKENHI-PROJECT-16K09295
[Presentation] Enrichment of Helicobacter pylori mutant strains after eradication therapy analyzed by gastric wash-based quantitative pyrosequencing and NGS.2018
- Author(s)
  Watanabe Y, Oikawa R, Yamamoto H, Itoh F.
- Organizer
  DDW2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09295
[Presentation] 早期胃がんESD症例におけるピロリ菌除菌前後の変異株含有率の変動2018
- Author(s)
  及川律子、渡邊嘉行、宮本秀一、佐藤義典、小野尚子、間部克裕、山本博幸、加藤元嗣、伊東文生
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-16K15435
[Presentation] Enrichment of Helicobacter pylori mutant strains after eradication therapy analyzed by gastric wash-based quantitative pyrosequencing.2018
- Author(s)
  Watanabe Y, Oikawa R, Yamamoto H, Itoh F.
- Organizer
  AACR Annual Meeting 2018
- Data Source
  KAKENHI-PROJECT-16K15435
[Presentation] Enrichment of Helicobacter pylori mutant strains after eradication therapy analyzed by gastric wash-based quantitative pyrosequencing2018
- Author(s)
  Yoshiyuki Watanabe, Ritsuko Oikawa, Hiroyuki Yamamoto, Fumio Itoh
- Organizer
  AACR Annual Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09295
[Presentation] ENRICHMENT OF HELICOBACTER PYLORI MUTANT STRAINS AFTER ERADICATION THERAPY ANALYZED BY GASTRIC WASH BASED PYROSEQUENCING AND NGS2018
- Author(s)
  Yoshiyuki Watanabe, Ritsuko Oikawa, Hiroyuki Yamamoto, Fumio Itoh
- Organizer
  DDW 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09295
[Presentation] Enrichment of Helicobacter pylori mutant strains after eradication therapy analyzed by gastric wash-based quantitative pyrosequencing.2018
- Author(s)
  Watanabe Y, Oikawa R, Yamamoto H, Itoh F.
- Organizer
  AACR2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09295
[Presentation] NGS解析を応用した宿主側及びHBV側要因からみた肝臓がん組み込み部位とメチル化異常の検討2017
- Author(s)
  渡邊嘉行、及川律子、山本博幸、四柳宏、伊東文生
- Organizer
  第114回日本内科学会総会・講演会
- Data Source
  KAKENHI-PROJECT-15H04304
[Presentation] ヒトとピロリ菌ゲノム解析に基づく“胃全体の情報を網羅した”次世代の胃癌バイオマーカーの開発と診断・治療・予防への応用2017
- Author(s)
  山本博幸、渡邊嘉行、及川律子、宮本秀一、佐藤義典、小野尚子、間部克裕、加藤元嗣、伊東文生
- Organizer
  第76回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-16K15435
[Presentation] ヒトとピロリ菌ゲノム解析による次世代の胃癌リスク診断・除菌治療・癌予防2017
- Author(s)
  山本博幸
- Organizer
  BIO tech 2017 アカデミックフォーラム
- Data Source
  KAKENHI-PROJECT-16K15435
[Presentation] 除菌治療後に胃内H. pylori（変異株）の含有比は変動する2017
- Author(s)
  渡邊嘉行、及川律子、宮本修一、佐藤義典、小野尚子、間部克裕、山本博幸、加藤元嗣、伊東文生
- Organizer
  第23回　日本ヘリコバクター学会
- Data Source
  KAKENHI-PROJECT-16K09295
[Presentation] Epigenetic alteration at HBV integrants is associated with methylation at flanking human genome2017
- Author(s)
  渡邊嘉行、及川律子、山本博幸、伊東文生
- Organizer
  The 107th Annual Meeting of the American Association for Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04304
[Presentation] 次世代シークエンサーによる胃内H.pylori菌遺伝子解析のテーラーメイド治療への応用2017
- Author(s)
  渡邊嘉行、山本博幸、伊東文生
- Organizer
  日本消化器病週間　JDDW2017
- Data Source
  KAKENHI-PROJECT-16K09295
[Presentation] がんゲノム解析の臨床応用と個別化・先制医療への展開2016
- Author(s)
  山本博幸
- Organizer
  第53回日本臨床分子医学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Invited
- Data Source
  KAKENHI-PROJECT-15H04304
[Presentation] G-NAVI 法による宿主側及びHBV 側要因からみた組み込み部位とメチル化異常の検討2016
- Author(s)
  渡邊嘉行、及川律子、山本博幸、四柳宏、伊東文生
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Data Source
  KAKENHI-PROJECT-15H04304
[Presentation] A Next-Generation Sequencing-based G-NaVI Method Revealed that DNA Methylation in the Integrated HBV Genome is Related to the Methylation Status of the Integration Sites within the Human Genome2016
- Author(s)
  山本博幸、渡邊嘉行、及川律子、渡邊綱正、四柳宏、伊東文生
- Organizer
  DDW2016
- Place of Presentation
  San Diego (U.S.A.)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04304
[Presentation] 次世代シークエンサーによるB型肝炎ウイルスDNA全組み込み解析に基づく発癌機構解明2016
- Author(s)
  山本博幸、渡邊嘉行、及川律子、山本雅一、國土典宏、田中真二、有井滋樹、四柳宏、小池和彦、伊東文生
- Organizer
  第53回日本臨床分子医学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Data Source
  KAKENHI-PROJECT-15H04304
[Presentation] 新規肝癌腫瘍マーカーとしての血清ラミニンγ2単鎖の有用性2016
- Author(s)
  清川博史，安田　宏，松本伸行，石井俊哉，奥瀬千晃，山本博幸，中川将利，吉田栄作，吉村　徹，清木元治，越川直彦，伊東文生.
- Organizer
  第52回日本肝臓学会総会
- Place of Presentation
  ホテルニューオータニ幕張（千葉県千葉市）
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-15K08655
[Presentation] 新規肝癌腫瘍マーカーとしての細胞外マトリックス関連分子の有用性2015
- Author(s)
  清川博史，安田宏，松本伸行，奥瀬千晃，石井俊哉，山本博幸，伊東文生，吉田栄作，吉村徹，越川直彦，清木元治
- Organizer
  第21回日本消化器関連学会週間JDDW 2015
- Place of Presentation
  東京・グランドプリンスホテル新高輪
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K08655
[Presentation] 高齢者の大腸鋸歯状病変における臨床病理学的特徴と分子異常の検討2014
- Author(s)
  能正勝彦，五十嵐央祥，伊藤美樹，内藤崇史，吉井新二，須河恭敬，三上雅史，高橋宏明，久須美貴哉，細川正夫，奥田博介，藤田昌弘，青木敬則，山本英一郎，足立　靖，沖田憲司，平田公一，鈴木　拓，山本博幸，篠村恭久
- Organizer
  第10回日本消化管学会総会学術集会
- Place of Presentation
  福島ビューホテル（福島市）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] 表在型食道胃接合部癌における分子生物学的異常の解析2014
- Author(s)
  伊藤美樹，能正勝彦，五十嵐央祥，内藤崇史，三橋　慧，田沼徳真，山本佳子，高橋宏明，細川正夫，山本博幸，篠村恭久
- Organizer
  第10回日本消化管学会総会学術集会
- Place of Presentation
  福島ビューホテル（福島市）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] Association between EBV infection and HER2 expression in gastric cancer2013
- Author(s)
  Mitsuhashi K, Sukawa Y, Nakazawa M, Naito T, Ito M, Igarashi H, Kunimoto H, Nosho K, Adachi Y, Yamamoto H, Takada K, Shinomura Y
- Organizer
  Digestive Disease Week 2013
- Place of Presentation
  Orange County Convention Center, Orlando, USA
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] 大腸鋸歯状病変におけるmicroRNA-31の役割2013
- Author(s)
  能正勝彦，五十嵐央祥，伊藤美樹，内藤崇史，三橋　慧，須河恭敬，丸山玲緒，山本英一郎，荻野周史，鈴木　拓，今井浩三，山本博幸，篠村恭久
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] 大腸癌の新規バイオマーカー探索を目指したEGFR下流シグナルを制御するマイクロRNAの検討2013
- Author(s)
  能正勝彦，五十嵐央祥，伊藤美樹，内藤崇史，三橋　慧，野島正寛，山本英一郎，吉井新二，奥田博介，高橋宏明，久須美貴哉，細川正夫，沖田憲司，平田公一，丸山玲緒，鈴木　拓，山本博幸，篠村恭久
- Organizer
  第79回大腸癌研究会
- Place of Presentation
  梅田スカイビル（大阪市）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] Associations among the HER2 signal-related factors thought to be predictive factors for the effectiveness of trastuzumab therapy in gastric cancer2013
- Author(s)
  Yamamoto H, Sukawa Y, Nakazawa M, Sumioka W, Watanabe Y, Maehata T, Morita R, Yoshida Y, Ishigooka S, Ozawa S, Matsuo Y, Hosoya K, Yamashita M, Taniguchi H, Nosho K, Suzuki H, Yasuda H, Imai K, Shinomura Y, Itoh F
- Organizer
  The 4th JCA-AACR Special Joint Conference
- Place of Presentation
  Tokyo Bay Maihama Hotel Club & Resorts, Urayasu, Japan
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] Analysis of the molecular features of elderly colorectal cancer patients using a large Japanese cohort study and the lmportance of sessile serrated adenoma/polyp (SSA/P) as a precursor lesion2013
- Author(s)
  Igarashi H, Nosho K, Ito M, Naito T, Mitsuhashi K, Sukawa Y, Mikami M, Yamamoto E, Nakazawa M, Sumioka W, Okuda H, Takahashi H, Kusumi T, Hosokawa M, Nojima M, Okita K, Suzuki H, Yamamoto H, Shinomura Y
- Organizer
  Digestive Disease Week 2013
- Place of Presentation
  Orange County Convention Center, Orlando, USA
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] 大腸鋸歯状病変におけるInsulin-like growth factor2（IGF2）differentially methylated region (DMR) 0メチル化レベルの解析―発癌機構の解明を目指して―2013
- Author(s)
  能正勝彦，伊藤美樹，五十嵐央祥，内藤崇史，三橋　慧，須河恭敬，足立　靖，吉井新二，鈴木　拓，山本博幸，荻野周史，篠村恭久
- Organizer
  第50回日本臨床分子医学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] microRNA-34b/c異常メチル化率測定による胃癌の異時性多発リスク予測2013
- Author(s)
  鈴木　亮，山本英一郎，鈴木　拓，野島正寛，丸山玲緒，能正勝彦，山本博幸，山野泰穂，菅井　有，篠村恭久
- Organizer
  第110回日本内科学会総会講演会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] Analysis of the insulin-like growth factor 2 (IGF2) differentially methylated region (DMR) 0 hypomethylation in carcinogenesis of colorectal serrated lesions2013
- Author(s)
  Nosho K, Yoshii S, Baba Y, Igarashi H, Ito M, Naito T, Sukawa Y, Mikami M, Takahashi T, Nakazawa M, Sumioka W, Takahashi H, Hosokawa M, Suzuki H, Adachi Y, Yamamoto H, Imai K, Ogino S, Shinomura Y
- Organizer
  Digestive Disease Week 2013
- Place of Presentation
  Orange County Convention Center, Orlando, USA
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] 胃癌におけるトラスツズマブ治療の効果予測因子となりうるHER2シグナル関連分子異常の関連の解析2013
- Author(s)
  山本博幸，須河恭敬，能正勝彦，前畑忠輝，谷口博昭，五十嵐央祥，伊藤美樹，内藤崇史，足立　靖，鈴木　拓，伊東文生，今井浩三，篠村恭久
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] 大規模コホートを用いた高齢者大腸癌と大腸鋸歯状病変の分子病理学的検討2013
- Author(s)
  沼田泰尚，能正勝彦，五十嵐央祥，伊藤美樹，内藤崇史，三橋　慧，三上雅史，高橋大賀，吉井新二，高橋宏明，久須美貴哉，細川正夫，山本英一郎，山下健太郎，有村佳昭，青木敬則，野村昌史，山本博幸，平田公一，篠村恭久
- Organizer
  第86回日本消化器内視鏡学会総会
- Place of Presentation
  グランドプリンスホテル新高輪（東京都港区）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] 大腸癌におけるmicroRNA-31発現とBRAF遺伝子変異・抗EGFR抗体薬感受性との関連性2013
- Author(s)
  五十嵐央祥，能正勝彦，伊藤美樹，野島正寛，吉井新二，丸山玲緒，内藤崇史，三橋　慧，山本英一郎，足立　靖，三上雅史，高橋宏明，奥田博介，細川正夫，沖田憲司，平田公一，鈴木　拓，山本博幸，篠村恭久
- Organizer
  第33回日本分子腫瘍マーカー研究会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] 早期胃がんの分子診断応用におけるBARHL2遺伝子高メチル化の有効性2013
- Author(s)
  前畑忠輝，渡邊嘉行，及川律子，吉田良仁，森田亮，細谷浩介，松本伸行，山本博幸，伊東文生
- Organizer
  第64回日本電気泳動学会総会
- Place of Presentation
  東北福祉大学ステーションキャンパス（仙台市）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] 日本人の高齢者における大腸癌および大腸鋸歯状腺腫の分子生物学的特徴2013
- Author(s)
  三橋　慧，能正勝彦，内藤崇史，松永康孝，伊藤美樹，五十嵐央祥，須河恭敬，山本英一郎，丸山玲緒，足立　靖，鈴木　拓，山本博幸，篠村恭久
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] Analysis of the genome-wide DNA methylation level in colorectal adenoma for detecting the precursor lesion of line extreme hypomethylated colorectal cancer2013
- Author(s)
  Nosho K, Igarashi H, Ito M, Naito T, Mitsuhashi K, Sukawa Y, Nakazawa M, Sumioka W, Yoshii S, Fujita M, Yamamoto E, Adachi Y, Baba Y, Nojima M, Maruyama R, Suzuki H, Yamamoto H, Imai K, Shinomura Y
- Organizer
  Digestive Disease Week 2013
- Place of Presentation
  Orange County Convention Center, Orlando, USA
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] microRNA-31は大腸癌におけるBRAF遺伝子変異・予後と関連する2013
- Author(s)
  五十嵐央祥，能正勝彦，伊藤美樹，内藤崇史，三橋　慧，丸山玲緒，野島正寛，山本英一郎，吉井新二，足立　靖，鈴木　拓，山本博幸，篠村恭久
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] 大腸鋸歯状病変の進展および分化におけるIGF-2DMR低メチル化の役割2013
- Author(s)
  内藤崇史，能正勝彦，馬場祥史，伊藤美樹，五十嵐央祥，三橋　慧，山本英一郎，丸山玲緒，鈴木　拓，足立　靖，山本博幸，平田公一，篠村恭久
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] 表在型食道胃接合部癌における分子生物学的異常の解析2013
- Author(s)
  伊藤美樹，能正勝彦，五十嵐央祥，内藤崇史，三橋　慧，須河恭敬，田沼徳真，山本桂子，吉井新二，高橋宏明，細川正夫，山本博幸，篠村恭久
- Organizer
  第45回胃病態機能研究会
- Place of Presentation
  名古屋市立大学（名古屋市）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] 胃癌の異時性多発リスク予測マーカーとしてのmicroRNA-34b/c異常メチル化測定2013
- Author(s)
  鈴木　亮，山本英一郎，鈴木　拓，野島正寛，丸山玲緒，能正勝彦，山本博幸，山野泰穂，菅井　有，篠村恭久
- Organizer
  第50回日本臨床分子医学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] microRNA-34b/c異常メチル化率測定による胃癌の異時性多発リスク予測2013
- Author(s)
  鈴木亮,山本英一郎,鈴木拓,野島正寛,丸山玲緒,能正勝彦,山本博幸,山野泰穂,菅井有,篠村恭久
- Organizer
  第110回日本内科学会総会講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390200
[Presentation] Characteristics of and associations among the HER2 signal-related factors thought to be predictive factors for the effectiveness of trastuzumab therapy in gastric cancer2013
- Author(s)
  Ito M, Sukawa Y, Nosho K, Igarashi H, Naito T, Kunimoto H, Mitsuhashi K, Nakazawa M, Sumioka W, Adachi Y, Mikami M, Kawayama M, Suzuki H, Yamamoto H, Shinomura Y
- Organizer
  Digestive Disease Week 2013
- Place of Presentation
  Orange County Convention Center, Orlando, USA
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] 早期胃がんの分子診断応用におけるBARHL2遺伝子高メチル化の有用性2013
- Author(s)
  細谷浩介，渡邊嘉行，及川律子，森田亮，吉田良仁，前畑忠輝，松本伸行，山本博幸，伊東文生
- Organizer
  第33回日本分子腫瘍マーカー研究会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] 篠村恭久MCAmicroarrayを用いたヒト食道扁平上皮癌におけるゲノムワイドメチル化異常の解析とI型膜貫通糖蛋白質LRFN5不活化の同定2012
- Author(s)
  伊藤美樹、山本博幸、田沼徳真、谷口博昭、能正勝彦、須河泰敬、内藤崇史、鈴木拓、足立靖、高橋宏明、細川正夫、今井浩三
- Organizer
  第71回日本癌学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2012-09-20
- Data Source
  KAKENHI-PROJECT-23650616
[Presentation] 大腸腫瘍におけるニューロテンシン受容体１型遺伝子のメチル化と臨床的意義2012
- Author(s)
  山本英一郎
- Organizer
  第71回日本癌学会学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors.2012
- Author(s)
  鈴木拓,新沼猛,野島正寛,丸山玲緒,山本英一郎,甲斐正広,能正勝彦,山本博幸,時野隆至,今井浩三,篠村恭久
- Organizer
  第71回日本癌学会学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23390200
[Presentation] GISTの悪性度マーカーおよび治療標的としての non-coding RNA2012
- Author(s)
  新沼猛,鈴木拓,野島正寛,高丸博之,山本英一郎,能正勝彦,山本博幸,篠村恭久
- Organizer
  第8回日本消化管学会総会学術集会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23390200
[Presentation] 遺伝子異常に基づく消化器癌の分子診断と個別化治療2012
- Author(s)
  山本博幸, 他
- Organizer
  第71回日本癌学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2012-09-21
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] 消化管間質腫瘍におけるmicroRNA発現プロファイル解析2012
- Author(s)
  鈴木拓,新沼猛,野島正寛,山本英一郎,丸山玲緒,山本博幸,篠村恭久
- Organizer
  第49回日本臨床分子医学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23390200
[Presentation] 大腸癌の前癌病変におけるジェネティック・エピジェネティックな異常と臨床応用2012
- Author(s)
  山本英一郎, 他
- Organizer
  第8回日本消化管学会総会学術集会
- Place of Presentation
  仙台
- Year and Date
  2012-02-10
- Data Source
  KAKENHI-PROJECT-23390200
[Presentation] マイクロサテライト不安定性陽性ヒト癌におけるマイクロRNA生合成経路に関わる新たな遺伝子異常:同定と臨床応用2011
- Author(s)
  山本博幸, 他
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-23390200
[Presentation] マイクロサテライト不安定性陽性ヒト癌におけるマイクロRNA生合成経路に関わる新たな遺伝子異常 : 同定と臨床応用2011
- Author(s)
  山本博幸, 他
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] マイクロサテライト不安定性陽性ヒト癌におけるマイクロRNA生合成経路に関わる新たな遺伝子異常:同定と臨床応用2011
- Author(s)
  山本博幸, 他
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-23300366
[Presentation] CIMP大腸癌の起源2010
- Author(s)
  山本英一郎, 鈴木拓, 山野泰穂, 神前正幸, 甲斐正広, 菅井有, 時野隆至, 今井浩三, 篠村恭久, 豊田実
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] 未分化型胃癌におけるDNAメチル化異常の解明2010
- Author(s)
  高丸博之, 鈴木拓, 山本英一郎, 新沼猛, 田沼徳真, 安井寛, 甲斐正広, 山本博幸, 豊田実, 篠村恭久
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] 胃癌におけるmicroRNA34b/cのエピジェネティックな不活化2010
- Author(s)
  鈴木拓, 山本英一郎, 高丸博之, 五十嵐伸一, 野島正寛, 山本博幸, 豊田実, 今井浩三, 篠村恭久
- Organizer
  第6回日本消化管学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2010-02-19
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] GISTにおけるHNE-1低メチル化と悪性度との相関2010
- Author(s)
  新沼猛, 鈴木拓, 野島正寛, 五十嵐伸一, 山本英一郎, 高丸博之, 田沼徳真, 山本博幸, 時野隆至, 今井浩三, 豊田実, 篠村恭久
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] microRNAプロセシングに関わるTARBP2遺伝子の消化管癌における変異及び機能解析2010
- Author(s)
  宮本伸樹, 山本博幸, 宮本千絵, 谷口博昭, 足立靖, 日崎恵一, 井伊正則, 田沼徳真, 須河恭敬, 佐々木茂, 有村佳昭, 篠村恭久
- Organizer
  第6回日本消化管学会学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] 消化管間質腫瘍におけるLINE-1低メチル化と悪性度との相関2010
- Author(s)
  山本英一郎, 鈴木拓, 新沼猛, 五十嵐伸一, 山本博幸, 豊田実, 篠村恭久
- Organizer
  第21回日本消化器癌発生学会総会
- Place of Presentation
  軽井沢
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] 大腸癌においてエピジェネティックに不活化したmicroRNAの網羅的解析2009
- Author(s)
  鈴木拓, 五十嵐伸一, 高丸博之, 新沼猛, 山本博幸, 時野隆至, 今井浩三, 豊田実, 篠村恭久
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] 多発胃癌背景胃粘膜における異常メチル化2009
- Author(s)
  山本英一郎, 豊田実, 鈴木拓, 山本博幸, 山野泰穂, 菅井有, 今井浩三, 篠村恭久
- Organizer
  第20回日本消化器癌発生学会総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] 新規エピゲノム解析法の開発と消化器癌発生の分子機構2009
- Author(s)
  豊田実, 鈴木拓, 山本英一郎, 山野泰穂, 篠村恭久
- Organizer
  第5回日本消化管学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] 胃癌の進展におけるラミニンβ3とγ2の共発現の役割2009
- Author(s)
  井伊正則, 山本博幸, 足立靖, 谷口博昭, 日崎恵一, 大橋広和, 田沼徳真, 國本浩明, 阿久津典之, 佐々木茂, 有村佳昭, 今井浩三, 篠村恭久
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] TARBP2遺伝子変異を介したmicroRNAプロセシング異常による新しい消化器発癌機構2009
- Author(s)
  山本博幸
- Organizer
  第68回日本癌学会総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] 大腸癌におけるIGFBP7のメチル化とCIMPとの相関2009
- Author(s)
  鈴木拓, 五十嵐伸一, 高丸博之, 新沼猛, 山本英一郎, 野島正寛, 山本博幸, 豊田実, 今井浩三, 篠村恭久
- Organizer
  第20回日本消化器癌発生学会総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] Epigenetic downregulation of the hedgehog interacting protein gene is frequently involved in gastrointestinal tumorigenesis.2008
- Author(s)
  Yamamoto H., et al.
- Organizer
  Digestive Disease Week 2008
- Place of Presentation
  San Diego, USA
- Year and Date
  2008-05-18
- Data Source
  KAKENHI-PROJECT-19659188
[Presentation] Relationship between laterally spreading Type, JC Virus and methylator phenotype in colorectal adenoma.2008
- Author(s)
  Yamamoto H., et al.
- Organizer
  Digestive Disease Week 2008
- Place of Presentation
  San Diego, USA
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-19659188
[Presentation] Blockade of insulin-like growth factor-I receptor is a useful anticancer therapeutic for esophageal squamous cell carcinoma.2008
- Author(s)
  Yamamoto H., et al.
- Organizer
  Digestive Disease Week 2008
- Place of Presentation
  San Diego, USA
- Year and Date
  2008-05-21
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] Relationship between laterally spreading Type, JC virus and methylator phenotype in colorectal adenoma.2008
- Author(s)
  Yamamoto H., et al.
- Organizer
  Digestive Disease Week 2008
- Place of Presentation
  San Diego, USA
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] JCウイルスT抗原発現陽性胃癌のジェネティックおよびエピジェネティックな異常2008
- Author(s)
  山本博幸, 山岡聡, 宮本千絵, 井伊正則, 日崎恵一, 田沼徳真, 宮本伸樹, 奥田博介, 足立靖, 佐々木茂, 有村佳昭, 今井浩三, 篠村恭久
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] High levels of aberrant DNA methylation in Helicobacter pylori-related pangastritis.2008
- Author(s)
  Yamamoto E., et al.
- Organizer
  Digestive Disease Week 2008
- Place of Presentation
  San Diego, USA
- Year and Date
  2008-05-18
- Data Source
  KAKENHI-PROJECT-19659188
[Presentation] Blockade of insulin-like growth factor-I receptor is auseful anticancer therapeutic for esophageal squamous cell careinoma.2008
- Author(s)
  Yamamoto H., et al.
- Organizer
  Digestive Disease Week 2008
- Place of Presentation
  San Diego, USA
- Year and Date
  2008-05-21
- Data Source
  KAKENHI-PROJECT-19659188
[Presentation] ゲノムワイドな低メチル化を指標とした胃癌の診断と発癌リスク予測への応用2008
- Author(s)
  山本英一郎, 豊田実, 篠村恭久
- Organizer
  第16回日本消化器関連学会週間
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] IGF-I受容体標的治療はマトリライシンの抑制を介してヒト消化器癌の浸潤を抑制する2008
- Author(s)
  足立靖, 山本博幸, 井伊正則, 有村佳昭, 遠藤高夫, 加藤康夫, 今井浩三, 篠村恭久
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] High levels of aberrant DNA methylation in Helicobacter pylori-related pangastritis.2008
- Author(s)
  Yamamoto E., et al.
- Organizer
  Digestive Disease Week 2008
- Place of Presentation
  San Diego, USA
- Year and Date
  2008-05-18
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] Epigegetic downregulation of the hedgehog interacing protein gene is frequently involved in gastrointestinal tumorigenesis.2008
- Author(s)
  Yamamoto H., et al.
- Organizer
  Digestive Disease Week 2008
- Place of Presentation
  San Diego, USA
- Year and Date
  2008-05-18
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] 皺壁肥大型胃炎におけるゲノムワイドな低メチル化とCpGアイランド高メチル化の関連2008
- Author(s)
  山本英一郎, 豊田実, 鈴木拓, 野島正寛, 丸山玲緒, 五十嵐伸一, 時野隆至, 今井浩三, 篠村恭久
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20390210
[Presentation] IGF-1レセプターを標的とした消化器癌の分子治療2007
- Author(s)
  山本博幸
- Organizer
  第44回日本臨床分子医学会学術集会
- Place of Presentation
  和歌山市
- Year and Date
  2007-07-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390220
[Presentation] IGF-Iレセプターを標的とした消化器癌の分子治療2007
- Author(s)
  山本博幸
- Organizer
  第44回日本臨床分子医学会学術集会
- Place of Presentation
  和歌山市
- Year and Date
  2007-07-21
- Data Source
  KAKENHI-PROJECT-18390220
[Presentation] ヒト胃癌におけるマイクロサテライト不安定性と分子病態2007
- Author(s)
  山本博幸
- Organizer
  第17回日本消化器癌発生学会総会
- Place of Presentation
  札幌市
- Year and Date
  2007-11-08
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390220
[Presentation] Molecular pathology of gastric cancer with microsatellite instability2007
- Author(s)
  Hiroyuki, Yamamoto
- Organizer
  The 17th Meeting of the
- Place of Presentation
  Sapporo
- Year and Date
  2007-11-08
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390220
[Presentation] Molecular therapy targetting IGF-I receptor for gastrointestinal Cancer2007
- Author(s)
  Hiroyuki, Yamamoto
- Organizer
  The 44th Meeting of the
- Place of Presentation
  Wakayama
- Year and Date
  2007-07-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390220

1. ITOH Fumio (90223180)

# of Collaborated Projects: 15 results

# of Collaborated Products: 12 results
2. SHINOMURA Yasuhisa (90162619)

# of Collaborated Projects: 8 results

# of Collaborated Products: 84 results
3. WATANABE Yoshiyuki (90329243)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
4. WATANABE Yoshiyuki (90534199)

# of Collaborated Projects: 5 results

# of Collaborated Products: 26 results
5. IMAI Kohzoh (60117603)

# of Collaborated Projects: 5 results

# of Collaborated Products: 11 results
6. SASAKI Shigeru (10305229)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
7. ENDO Takao (40191928)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
8. Yasuda Hiroshi (80262129)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
9. TOYOTA Minoru (70270676)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
10. SUZUKI Hiromu (20381254)

# of Collaborated Projects: 3 results

# of Collaborated Products: 42 results
11. NOSHO Katsuhiko (10597339)

# of Collaborated Projects: 3 results

# of Collaborated Products: 43 results
12. ARIMURA Yoshiaki (80305218)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. Okuse Chiaki (00318940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. YOSHIDA Yukinari (60311411)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. ADACHI Masaaki (70240926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. 松尾康正 (70724756)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 渡邊綱正 (20338528)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 矢作直久 (90292937)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 及川律子 (60449395)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. Koshikawa Naohiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
21. TANIGUCHI Hiroaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Yamamoto Hiroyuki 山本 博幸

YAMAMOTO Hiroyuki 山本 博幸

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人工知能・新型ゲノムデータ駆動型アプローチに基づく革新的胃癌統合医療の創成Principal Investigator

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Novel suppression of gastric carcinogenesis based on the spatiotemporal elucidation of H. pylori genome alterations identified using clinical samplesPrincipal Investigator

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Elucidation and regulation of gastric carcinogeneis based on the next-generation integrated analysis of DNA integration and stromal cellsPrincipal Investigator

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Yamamoto Hiroyuki 山本博幸

YAMAMOTO Hiroyuki 山本博幸