Yamamoto Hiromasa 山本寛斉

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YAMAMOTO Hiromasa 山本寛斉

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Researcher Number	40467733
Other IDs	https://orcid.org/0000-0002-5330-5460
Affiliation (Current)	2025: 島根大学, 学術研究院医学・看護学系, 教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 島根大学, 学術研究院医学・看護学系, 教授 2021 – 2023: 岡山大学, 大学病院, 講師 2012 – 2020: 岡山大学, 大学病院, 助教 2017: 岡山大学, 岡山大学病院, 助教 2015: 岡山大学, 病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 55040:Respiratory surgery-related / Respiratory surgery / Thoracic surgery Except Principal Investigator Basic Section 55040:Respiratory surgery-related / Respiratory surgery / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Basic Section 50010:Tumor biology-related / Basic Section 55010:General surgery and pediatric surgery-related
Keywords	Principal Investigator 肺癌 / 腫瘍微小環境 / 原発性肺癌 / 肉腫肺転移 / 三次元培養 / EGFR遺伝子変異 / LRIG1 / EGFR / 上皮間葉系移行 / 上皮間葉移行 … More / マイクロRNA / 薬剤耐性機構 / EGFRチロシンキナーゼ阻害剤耐性 / 放射線治療 / Hsp90阻害剤 … More Except Principal Investigator 肺癌 / 薬剤耐性 / HER2 / がん微小環境 / 非小細胞肺がん / 外科 / 癌 / 悪性胸膜中皮腫 / 空間解析 / マルチオミクス解析 / がん関連線維芽細胞 / ERBB2 / 次世代シーケンサー / EGFR / 非小細胞肺癌 / 癌幹細胞 / 線溶阻害因子 / ディスバイオーシス / メタゲノム解析 / COPD / 腫瘍免疫 / B細胞 / 腫瘍免疫療法 / TLS / 腫瘍浸潤B細胞 / 空間マルチオミクス解析 / 微小環境 / 血管内皮細胞 / マトリセルラー蛋白 / マトリセルラータンパク質 / 肺腺癌 / 腫瘍免疫応答 / 内在性レトロウイルス / ドライバー遺伝子 / 精密医療 / パスウェイ / 肺腺がん / EGFR遺伝子変異 / 併用療法 / 耐性獲得メカニズム / ドラッグリポジショニング / ドライバー遺伝子変異 / VEGF受容体阻害薬 / PD-1阻害薬 / EGFR-TKI / 耐性 / パスウェイ解析 / 遺伝子発現データ解析 / バイオインフォマティクス / S100 / 抗S100A8/A9中和抗体 / S100A9 / S100A8 / 虚血再灌流障害 / 肺移植 / 腺癌 / 胚細胞変異 / 次世代シーケンス / 家族性腫瘍 / 家族性癌 / Whole Genome Sequencing / Whole Exome Sequencing / 家族性肺癌 / 肺線維化 / RAGE / ダメージ関連分子パターン / 腫瘍幹細胞マーカー / DCLK1 / HER異常 / 胃がん / 乳がん / 肺がん / HER2異常 / 耐性克服 / 耐性機序 / TDM1 / 耐性化機序 / 乳癌 / 分子標的治療 / HER2陽性 / 転移乳がん / 胸部悪性腫瘍 / 抗体療法 / 炎症 / 癌微小環境 / 上皮成長因子受容体チロシンキナーゼ阻害剤耐性 / Elacrida / ABCB1阻害剤 / EGFR-TKI耐性 / 抗PD-1抗体 / メトホルミン / サイトケラチン19 / 分子標的治療薬 / PDX / EMT / 次世代シークエンサー / 分子バーコード / 分子標的薬 / MHC Class1 / MHC Class-I / GRP78 / MHC Class I / NK細胞 / REIC / 遺伝子治療 / REIC遺伝子 / チロシンキナーゼ阻害剤 / 遺伝子変異 / マイクロRNA / 上皮成長因子受容体チロシンキナーゼ阻害薬 / 上皮間葉移行 / 上皮成長因子受容体チロシンキナーゼ阻害剤 / 原発性肺癌 Less

樹状細胞の活性化を介した抗腫瘍免疫応答の増強による新規肺腺癌治療戦略の基礎的検討
- Principal Investigator
  
  土生智大
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Okayama University
Clarification of spatiotemporal diversity in tumor microenvironment promoting lung metastases from bone and soft tissue sarcomaPrincipal Investigator
- Principal Investigator
  
  山本寛斉
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Shimane University
Development of a novel therapeutic strategy targeting the microenvironment that tolerates the progression of refractory lung cancer
- Principal Investigator
  
  枝園和彦
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Okayama University
Functional analysis of TLS, tumor-infiltrating B-cell, by spatial multi-omics profiling and its application to tumor immunotherapy
- Principal Investigator
  
  冨田秀太
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Okayama University
メタゲノム解析によるCOPD合併肺がんの臓器横断的ディスバイオーシスの解明
- Principal Investigator
  
  枝園和彦
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Okayama University
Elucidation of Tumor Microenvironment Network Regulated by Fibrinolysis Inhibitory Factor and Its Therapeutic Application
- Principal Investigator
  
  伊達慶一
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Okayama University
Clarification of the mechanism for endogenous retrovirus to get involved in the antitumor immunity response
- Principal Investigator
  
  豊岡伸一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Okayama University
マトリセルラータンパク質阻害によるがん微小環境の破壊と抗腫瘍効果の検討
- Principal Investigator
  
  豊岡伸一
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Okayama University
Exploration of the novel therapeutic target for lung cancer based on the analysis of the characteristics of tumor cells derived from 3D culturePrincipal Investigator
- Principal Investigator
  
  山本寛斉
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Shimane University
  Okayama University
Exploring germline mutations and therapies for hereditary lung cancer using next generation sequencing
- Principal Investigator
  
  Maki Yuho
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  National Hospital Organization Shikoku Cancer Center
Elucidation of the role of S100A8/A9 in pulmonary ischemia-reperfusion injury and development of new therapeutic strategies
- Principal Investigator
  
  Okazaki Mikio
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Okayama University
Development of next-generation precision medicine targeting the pathways on which driver gene mutation-positive lung cancer depends
- Principal Investigator
  
  Tomida Shuta
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Okayama University
Treatment strategy overcoming HER2 targetted drug resistance
- Principal Investigator
  
  Shien Tadahiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Okayama University
Development of a new treatment strategy for HER2-alterated lung cancer
- Principal Investigator
  
  Soh Junichi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Kindai University
Novel treatment strategy for malignant pleural mesothelioma targeting the tumor stem cell marker DCLK1
- Principal Investigator
  
  Miyoshi Shinichiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Okayama University
Development of the novel therapy focused on damage-associated molecular patterns (DAMPs) for lung fibrosis-related diseases
- Principal Investigator
  
  Toyooka Shinichi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Okayama University
Novel therapeutic strategy focused on EGFR-binding protein LRIG1 for EGFR-mutant lung cancerPrincipal Investigator
- Principal Investigator
  
  Yamamoto Hiromasa
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Okayama University
Development of innovative therapeutic antibodies targeting the inflammatory tumor microenvironment in refractory thoracic tumors
- Principal Investigator
  
  Toyooka Shinichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Okayama University
Development of new therapeutic strategy based on gene expression and mutation profiles in EGFR mutant lung cancer
- Principal Investigator
  
  Toyooka Shinichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory surgery
- Research Institution
  Okayama University
Novel therapeutic method for HER2 active cancer focusing on HER2 novel binding molecule cytokeratin 19
- Principal Investigator
  
  SOH JUNICHI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Okayama University
Development of new immunotherapy for lung cancer by combined application of diabetes drug metformin and anti-PD-1 antibody
- Principal Investigator
  
  Miyoshi Shinichiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory surgery
- Research Institution
  Okayama University
Clarification of the mechanism of drug resistance focused on microRNAs associated with epithelial-mesenchymal transition in lung cancerPrincipal Investigator
- Principal Investigator
  
  Yamamoto Hiromasa
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory surgery
- Research Institution
  Okayama University
Development of new therapeutic strategy for EGFR-TKI resistant non-small cell lung cancer.
- Principal Investigator
  
  Asano Hiroaki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Okayama University
Identification of novel targets in the treatment of lung cancer
- Principal Investigator
  
  Miyoshi Shinichiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory surgery
- Research Institution
  Okayama University
New therapeutic strategy for non-small cell lung cancer by REIC gene therapy
- Principal Investigator
  
  Toyooka Shinichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory surgery
- Research Institution
  Okayama University
Understanding and overcoming drug resistance to EGFR-inhibitors for lung cancer
- Principal Investigator
  
  Toyooka Shinichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory surgery
- Research Institution
  Okayama University
New treatment strategy for malignant pleural mesothelioma focusing on microRNAs related to cancer stem cell makers
- Principal Investigator
  
  SOH JUNICHI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Okayama University
The new strategy for lung cancer treatment by Hsp90 inhibitors and radiation therapyPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Hiromasa
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  Okayama University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Correction to: Periostin secreted by cancer-associated fibroblasts promotes cancer progression and drug resistance in non-small cell lung cancer2023
- Author(s)
  Takatsu Fumiaki、Suzawa Ken、Tomida Shuta、Thu Yin Min、Sakaguchi Masakiyo、Toji Tomohiro、Ohki Masayoshi、Tsudaka Shimpei、Date Keiichi、Matsuda Naoki、Iwata Kazuma、Zhu Yidan、Nakata Kentaro、Shien Kazuhiko、Yamamoto Hiromasa、Nakayama Akiko、Okazaki Mikio、Sugimoto Seiichiro、Toyooka Shinichi
- Journal Title
  
  Journal of Molecular Medicine
  
  Volume: 102 Issue: 1 Pages: 147-147
- DOI
  10.1007/s00109-023-02408-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24421, KAKENHI-PROJECT-23K27439
[Journal Article] Periostin secreted by cancer-associated fibroblasts promotes cancer progression and drug resistance in non-small cell lung cancer2023
- Author(s)
  Takatsu F, Suzawa K, Tomida S, Thu YM, Sakaguchi M, Shien K, Yamamoto H, Nakayama A, Okazaki M, Sugimoto S, Toyooka S
- Journal Title
  
  Journal of molecular medicine (Berlin, Germany)
  
  Volume: 101 Issue: 12 Pages: 1603-1614
- DOI
  10.1007/s00109-023-02384-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H04923, KAKENHI-PROJECT-23K27439, KAKENHI-PROJECT-23K27688
[Journal Article] Identification of genetic loci associated with renal dysfunction after lung transplantation using an ethnic-specific single-nucleotide polymorphism array2023
- Author(s)
  Tomioka Yasuaki、Sugimoto Seiichiro、Yamamoto Haruchika、Tomida Shuta、Shiotani Toshio、Tanaka Shin、Shien Kazuhiko、Suzawa Ken、Miyoshi Kentaroh、Otani Shinji、Yamamoto Hiromasa、Okazaki Mikio、Yamane Masaomi、Toyooka Shinichi
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 8912-8912
- DOI
  10.1038/s41598-023-36143-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08974, KAKENHI-PROJECT-23K27688
[Journal Article] Tumor Microenvironment Landscape of NSCLC Reveals Resistance Mechanisms for Programmed Death-Ligand 1 Blockade After Chemoradiotherapy: A Multicenter Prospective Biomarker Study (WJOG11518L:SUBMARINE)2023
- Author(s)
  Haratani K、Nakamura A、Mamesaya N、Mitsuoka S、Yoneshima Y、Saito R、Tanizaki J、Fujisaka Y、Hata A、Tsuruno K、Sakamoto T、Teraoka S、Oki M、Watanabe H、Sato Y、Nakano Y、Otani T、Sakai K、Tomida Shuta、Chiba Y、Ito A、Nishio K、Yamamoto N、Nakagawa K、Hayashi H
- Journal Title
  
  Journal of Thoracic Oncology
  
  Volume: 18 Issue: 10 Pages: 1334-1350
- DOI
  10.1016/j.jtho.2023.06.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K27688
[Journal Article] S100A8/A9 as a prognostic biomarker in lung transplantation2023
- Author(s)
  Nakata Kentaro、Okazaki Mikio、Kawana Shinichi、Kubo Yujiro、Shimizu Dai、Tanaka Shin、Hashimoto Kohei、Suzawa Ken、Shien Kazuhiko、Miyoshi Kentaroh、Yamamoto Hiromasa、Sugimoto Seiichiro、Toyooka Shinichi
- Journal Title
  
  Clinical Transplantation
  
  Volume: 37 Pages: 15006-15006
- DOI
  10.1111/ctr.15006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09164
[Journal Article] One-step nucleic acid amplification for intraoperative diagnosis of lymph node metastasis in lung cancer patients: a single-center prospective study2022
- Author(s)
  Namba Kei、Suzawa Ken、Shien Kazuhiko、Miura Akihiro、Takahashi Yuta、Miyauchi Shunsaku、Araki Kota、Nakata Kentaro、Tomida Shuta、Tanaka Shin、Miyoshi Kentaroh、Otani Shinji、Yamamoto Hiromasa、Okazaki Mikio、Sugimoto Seiichiro、Soh Junichi、Yamane Masaomi、Toyooka Shinichi
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1
- DOI
  10.1038/s41598-022-11064-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03771
[Journal Article] Functional Blockage of S100A8/A9 Ameliorates Ischemia Reperfusion Injury in the Lung2022
- Author(s)
  Nakata Kentaro、Okazaki Mikio、Sakaue Tomohisa、Kinoshita Rie、Komoda Yuhei、Shimizu Dai、Yamamoto Haruchika、Tanaka Shin、Suzawa Ken、Shien Kazuhiko、Miyoshi Kentaroh、Yamamoto Hiromasa、Ohara Toshiaki、Sugimoto Seiichiro、Yamane Masaomi、Matsukawa Akihiro、Sakaguchi Masakiyo、Toyooka Shinichi
- Journal Title
  
  Bioengineering
  
  Volume: 9 Issue: 11 Pages: 673-673
- DOI
  10.3390/bioengineering9110673
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09164, KAKENHI-PROJECT-20KK0203, KAKENHI-PROJECT-20H03516, KAKENHI-PROJECT-20K07636, KAKENHI-PROJECT-22H04923
[Journal Article] Drug repositioning of tranilast to sensitize a cancer therapy by targeting cancer‐associated fibroblast2022
- Author(s)
  Ochi Kosuke、Suzawa Ken、Thu Yin Min、Takatsu Fumiaki、Tsudaka Shimpei、Zhu Yidan、Nakata Kentaro、Takeda Tatsuaki、Shien Kazuhiko、Yamamoto Hiromasa、Okazaki Mikio、Sugimoto Seiichiro、Shien Tadahiko、Okamoto Yoshiharu、Tomida Shuta、Toyooka Shinichi
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 10 Pages: 3428-3436
- DOI
  10.1111/cas.15502
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03771
[Journal Article] Oncogenic potential of human pluripotent stem cell‐derived lung organoids with <scp>HER2</scp> overexpression2021
- Author(s)
  Miura Akihiro、Yamada Daisuke、Nakamura Masahiro、Tomida Shuta、Shimizu Dai、Jiang Yan、Takao Tomoka、Yamamoto Hiromasa、Suzawa Ken、Shien Kazuhiko、Yamane Masaomi、Sakaguchi Masakiyo、Toyooka Shinichi、Takarada Takeshi
- Journal Title
  
  International Journal of Cancer
  
  Volume: 149 Issue: 8 Pages: 1593-1604
- DOI
  10.1002/ijc.33713
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03516, KAKENHI-PROJECT-20H03771, KAKENHI-PROJECT-21K07192, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-23K21368
[Journal Article] YES1 activation induces acquired resistance to neratinib in HER2 ‐amplified breast and lung cancers2020
- Author(s)
  Takeda Tatsuaki、Yamamoto Hiromasa、Suzawa Ken、Tomida Shuta、Miyauchi Shunsaku、Araki Kota、Nakata Kentaro、Miura Akihiro、Namba Kei、Shien Kazuhiko、Soh Junichi、Shien Tadahiko、Kitamura Yoshihisa、Sendo Toshiaki、Toyooka Shinichi
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 3 Pages: 849-856
- DOI
  10.1111/cas.14289
- NAID
  120006839439
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09070, KAKENHI-PROJECT-19K09285, KAKENHI-PROJECT-17K10784
[Journal Article] The heterodimer S100A8/A9 is a potent therapeutic target for idiopathic pulmonary fibrosis2020
- Author(s)
  Araki Kota、Kinoshita Rie、Tomonobu Nahoko、Gohara Yuma、Tomida Shuta、Takahashi Yuta、Senoo Satoru、Taniguchi Akihiko、Itano Junko、Yamamoto Ken-ichi、Murata Hitoshi、Suzawa Ken、Shien K、Yamamoto H、Okazaki M、Sugimoto S、Ichimura K、Nishibori M、Miyahara N、Toyooka S、Sakaguchi Masakiyo
- Journal Title
  
  Journal of Molecular Medicine
  
  Volume: 99 Issue: 1 Pages: 131-145
- DOI
  10.1007/s00109-020-02001-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07369, KAKENHI-PROJECT-19H03746, KAKENHI-PROJECT-20H03516, KAKENHI-PROJECT-16H06277
[Journal Article] Antitumor Effects of Pan-RAF Inhibitor LY3009120 Against Lung Cancer Cells Harboring Oncogenic BRAF Mutation2020
- Author(s)
  MIYAUCHI SHUNSAKU、SHIEN KAZUHIKO、TAKEDA TATSUAKI、ARAKI KOTA、NAKATA KENTARO、MIURA AKIHIRO、TAKAHASHI YUTA、KURIHARA EISUKE、OGOSHI YUSUKE、NAMBA KEI、SUZAWA KEN、YAMAMOTO HIROMASA、OKAZAKI MIKIO、SOH JUNICHI、TOMIDA SHUTA、YAMANE MASAOMI、SAKAGUCHI MASAKIYO、TOYOOKA SHINICHI
- Journal Title
  
  Anticancer Research
  
  Volume: 40 Issue: 5 Pages: 2667-2673
- DOI
  10.21873/anticanres.14237
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03516, KAKENHI-PROJECT-20H03771, KAKENHI-PROJECT-16H06277
[Journal Article] Overcoming epithelial-mesenchymal transition-mediated drug resistance with monensin-based combined therapy in non-small cell lung cancer2020
- Author(s)
  Ochi Kosuke、Suzawa Ken、Tomida Shuta、Shien Kazuhiko、Takano Jui、Miyauchi Shunsaku、Takeda Tatsuaki、Miura Akihiro、Araki Kota、Nakata Kentaro、Yamamoto Hiromasa、Okazaki Mikio、Sugimoto Seiichiro、Shien Tadahiko、Yamane Masaomi、Azuma Kazuo、Okamoto Yoshiharu、Toyooka Shinichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 529 Issue: 3 Pages: 760-765
- DOI
  10.1016/j.bbrc.2020.06.077
- NAID
  120007120054
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03771
[Journal Article] Anti-tumor effect of neratinib against lung cancer cells harboring HER2 oncogene alterations.2019
- Author(s)
  Ogoshi Y, Shien K, Yoshioka T, Torigoe H, Sato H, Sakaguchi M, Tomida S, Namba K, Kurihara E, Takahashi Y, Suzawa K, Yamamoto H, Soh J, Toyooka S
- Journal Title
  
  Oncol Lett.
  
  Volume: - Pages: 2729-2736
- DOI
  10.3892/ol.2019.9908
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03577, KAKENHI-PROJECT-16K10681
[Journal Article] Activation of AXL as a Preclinical Acquired Resistance Mechanism Against Osimertinib Treatment in EGFR-Mutant Non-Small Cell Lung Cancer Cells2019
- Author(s)
  Namba Kei、Shien Kazuhiko、Takahashi Yuta、Torigoe Hidejiro、Sato Hiroki、Yoshioka Takahiro、Takeda Tatsuaki、Kurihara Eisuke、Ogoshi Yusuke、Yamamoto Hiromasa、Soh Junichi、Tomida Shuta、Toyooka Shinichi
- Journal Title
  
  Molecular Cancer Research
  
  Volume: 17 Issue: 2 Pages: 499-507
- DOI
  10.1158/1541-7786.mcr-18-0628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10784, KAKENHI-PROJECT-16H05431, KAKENHI-PROJECT-17K16608
[Journal Article] Application of amplicon-based targeted sequencing with the molecular barcoding system to detect uncommon minor EGFR mutations in patients with treatment-naive lung adenocarcinoma2019
- Author(s)
  Namba Kei、Tomida Shuta、Matsubara Takehiro、Takahashi Yuta、Kurihara Eisuke、Ogoshi Yusuke、Yoshioka Takahiro、Takeda Tatsuaki、Torigoe Hidejiro、Sato Hiroki、Shien Kazuhiko、Yamamoto Hiromasa、Soh Junichi、Tsukuda Kazunori、Toyooka Shinichi
- Journal Title
  
  BMC Cancer
  
  Volume: 19 Issue: 1 Pages: 1-9
- DOI
  10.1186/s12885-019-5374-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10784, KAKENHI-PROJECT-16H05431
[Journal Article] Acquired resistance mechanisms to afatinib in HER2-amplified gastric cancer cells2019
- Author(s)
  Yoshioka, T. Shien, K. Takeda, T. Takahashi, Y. Kurihara, E. Ogoshi, Y. Namba, K. Torigoe, H. Sato, H. Tomida, S. Yamamoto, H. Soh, J. Fujiwara, T. Toyooka, S.
- Journal Title
  
  Cancer Sci
  
  Volume: 110 Issue: 8 Pages: 2549-2557
- DOI
  10.1111/cas.14089
- NAID
  120006816640
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09285, KAKENHI-PROJECT-17K10784
[Journal Article] Tumor-suppressive effect of LRIG1, a negative regulator of ErbB, in non-small cell lung cancer harboring mutant EGFR2018
- Author(s)
  Torigoe H, Yamamoto H, Sakaguchi M, Youyi C, Numba K, Sato H, Shien K, Soh J, Suzawa K, Tomida S, Tsukuda K, Miyoshi S, Toyooka S
- Journal Title
  
  Carcinogenesis
  
  Volume: - Issue: 5 Pages: 719-727
- DOI
  10.1093/carcin/bgy044
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03577, KAKENHI-PROJECT-18K08783
[Journal Article] Antitumor activity of pan-HER inhibitors in HER2-positive gastric cancer.2018
- Author(s)
  Yoshioka T, Shien K, Namba K, Torigoe H, Sato H, Tomida S, Yamamoto H, Asano H, Soh J, Tsukuda K, Nagasaka T, Fujiwara T, Toyooka S.
- Journal Title
  
  Cancer Sci.
  
  Volume: 109 Issue: 4 Pages: 1166-1176
- DOI
  10.1111/cas.13546
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10681, KAKENHI-PROJECT-18K18464, KAKENHI-PROJECT-18H03554, KAKENHI-PROJECT-15H03034
[Journal Article] Therapeutic Potential of Afatinib for Cancers with ERBB2 (HER2) Transmembrane Domain Mutations G660D and V659E.2018
- Author(s)
  Yamamoto H, Toyooka S, Ninomiya T, Matsumoto S, Kanai M, Tomida S, Kiura K, Muto M, Suzawa K, Desmeules P, Kris MG, Li BT, Ladanyi M.
- Journal Title
  
  Oncologist
  
  Volume: 23 Issue: 2 Pages: 150-154
- DOI
  10.1634/theoncologist.2017-0345
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10681, KAKENHI-PROJECT-17K10784, KAKENHI-PROJECT-18H02692
[Journal Article] Elacridar, a third-generation ABCB1 inhibitor, overcomes resistance to docetaxel in non-small cell lung cancer.2017
- Author(s)
  Chen H, Shien K, Suzawa K, Tsukuda K, Tomida S, Sato H, Torigoe H, Watanabe M, Namba K, Yamamoto H, Soh J, Asano H, Miyoshi S, Toyooka S
- Journal Title
  
  Oncology Letters
  
  Volume: 14(4) Issue: 4 Pages: 4349-4354
- DOI
  10.3892/ol.2017.6678
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10258
[Journal Article] Distant Bystander Effect of REIC/DKK3 Gene Therapy Through Immune System Stimulation in Thoracic Malignancies.2017
- Author(s)
  Suzawa K, Shien K, Peng H, Sakaguchi M, Watanabe M, Hashida S, Maki Y, Yamamoto H, Tomida S, Soh J, Asano H, Tsukuda K, Nasu Y, Kumon H, Miyoshi S, Toyooka S.
- Journal Title
  
  Anticancer Research
  
  Volume: 37 Pages: 301-307
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26670627
[Journal Article] Targeting the miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features.2017
- Author(s)
  Sato H, Shien K, Tomida S, Okayasu K, Suzawa K, Hashida S, Torigoe H, Watanabe M, Yamamoto H, Soh J, Asano H, Tsukuda K, Miyoshi S, Toyooka S.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 40847-40847
- DOI
  10.1038/srep40847
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01574, KAKENHI-PROJECT-16H06988, KAKENHI-PROJECT-15K19935
[Journal Article] Interaction of cytokeratin 19 head domain and HER2 in the cytoplasm leads to activation of HER2-Erk pathway.2016
- Author(s)
  Ohtsuka T, Sakaguchi M, Yamamoto H, Tomida S, Takata K, Shien K, Hashida S, Miyata-Takata T, Watanabe M, Suzawa K, Soh J, Youyi C, Sato H, Namba K, Torigoe H, Tsukuda K, Yoshino T, Miyoshi S, Toyooka S.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 39557-39557
- DOI
  10.1038/srep39557
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01574, KAKENHI-PROJECT-26293318, KAKENHI-PROJECT-26293352, KAKENHI-PROJECT-15K14382, KAKENHI-PROJECT-16K10681
[Journal Article] Antitumor effect of afatinib, as a human epidermal growth factor receptor 2-targeted therapy, in lung cancers harboring HER2 oncogene alterations2016
- Author(s)
  Ken Suzawa, Shinichi Toyooka, Masakiyo Sakaguchi, Mizuki Morita, Hiromasa Yamamoto, Shuta Tomida, Tomoaki Ohtsuka, Mototsugu Watanabe, Shinsuke Hashida, Yuho Maki, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda and Shinichiro Miyoshi
- Journal Title
  
  Cancer Science
  
  Volume: 107 Issue: 1 Pages: 45-52
- DOI
  10.1111/cas.12845
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293318, KAKENHI-PROJECT-26293352
[Journal Article] Establishment and molecular characterization of cell lines from Japanese patients with malignant pleural mesothelioma.2016
- Author(s)
  Suzawa K, Yamamoto H, Murakami T, Katayama H, Furukawa M, Shien K, Hashida S, Okabe K, Aoe K, Soh J, Asano H, Tsukuda K, Mimura Y, Toyooka S, Miyoshi S
- Journal Title
  
  Oncol Lett
  
  Volume: 1 Issue: 1 Pages: 705-712
- DOI
  10.3892/ol.2015.3955
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462195
[Journal Article] Acquisition of cancer stem cell-like properties in non-small cell lung cancer with acquired resistance to afatinib2015
- Author(s)
  Shinsuke Hashida, Hiromasa Yamamoto, Kazuhiko Shien, Yuichiro Miyoshi, Tomoaki Ohtsuka, Ken Suzawa, Mototsugu Watanabe, Yuho Maki, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
- Journal Title
  
  Cancer Science
  
  Volume: 10 Issue: 10 Pages: 1377-1384
- DOI
  10.1111/cas.12749
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293302
[Journal Article] Hsp90 inhibitor NVP-AUY922 enhances the radiation sensitivity of lung cancer cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors.2015
- Author(s)
  Hashida S, Yamamoto H, Shien K, Ohtsuka T, Suzawa K, Maki Y, Furukawa M, Soh J, Asano H, Tsukuda K, Miyoshi S, Kanazawa S, Toyooka S
- Journal Title
  
  Oncology Reports
  
  Volume: 33 Issue: 3 Pages: 1499-1504
- DOI
  10.3892/or.2015.3735
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24791462, KAKENHI-PROJECT-25293302
[Journal Article] TAE226, a Bis-Anilino Pyrimidine Compound, Inhibits the EGFR-Mutant Kinase Including T790M Mutant to Show Anti-Tumor Effect on EGFR-Mutant Non-Small Cell Lung Cancer Cells2015
- Author(s)
  Otani H, Yamamoto H, Takaoka M, Sakaguchi M, Soh J, Jida M, Ueno T, Kubo T, Asano H, Tsukuda K, Kiura K, Hatakeyama S, Kawahara E, Naomoto Y, Miyoshi S, Toyooka S
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 6 Pages: e0129838-e0129838
- DOI
  10.1371/journal.pone.0129838
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14382, KAKENHI-PROJECT-15H04830, KAKENHI-PROJECT-25293302, KAKENHI-PROJECT-26290039
[Journal Article] Anti-Cancer Effects of REIC/Dkk-3-encoding Adenoviral Vector for the Treatment of Non-small Cell Lung Cancer2014
- Author(s)
  Shien K, Tanaka N, Watanabe M, Soh J, Sakaguchi M, Matsuo K, Yamamoto H, Furukawa M, Asano H, Tsukuda K, Nasu Y, Huh NH, Miyoshi S, Kumon H, Toyooka S
- Journal Title
  
  PLoS ONE
  
  Volume: 9 Issue: 2 Pages: e87900-e87900
- DOI
  10.1371/journal.pone.0087900
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26290039, KAKENHI-PROJECT-26670627
[Presentation] 3D Culture Aggregation Morphology depends on Cell Phenotype and Gene Expression Profiles in Lung Cancer2024
- Author(s)
  Naohiro Hayashi, Shinpei Tsudaka, Ken Suzawa, Tomoaki Higashihara, Yin Min Thu, Atsushi Matsuoka, Daisuke Mizuno, Ryo Yoshichika, Fumiaki Mukohara, Mao Yoshikawa, Kazuhiko Shien, Hiromasa Yamamoto, Shinichi Toyooka
- Organizer
  AACR Annual Meeting 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08902
[Presentation] 空間マルチオミクス解析を駆使した肺がんドライバー遺伝子異常と微小環境との相互作用の解明2023
- Author(s)
  枝園和彦, 大亀正義, 冨田秀太, 松岡篤志, 吉川真生, 諏澤憲, 山本寛斉, 岡崎幹生, 杉本誠一郎, 遠西大輔, 豊岡伸一
- Organizer
  第64回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27687
[Presentation] 空間トランスクリプトーム解析による間質性肺炎合併肺癌の病態解明2023
- Author(s)
  大亀正義, 枝園和彦, 松岡篤志, 冨田秀太, 東原朋諒, 向原史晃, 林直宏. 土生智大, 吉川真生, 諏澤憲, 山本寛斉, 遠西大輔, 豊岡伸一
- Organizer
  第64回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27687
[Presentation] Periostin secreted by cancer-associated fibroblasts promotes cancer progression and drug resistance in non-small cell lung cancer2023
- Author(s)
  Mao Yoshikawa, Ken Suzawa, Fumiaki Takatsu, Tomohiro Habu, Kazuma Iwata, Masayoshi Ohki, Naoki Matsuda, Yin Min Zhu, Kazuhiko Shien, Hiromasa Yamamoto, Shinichi Toyooka
- Organizer
  AACR ANNUAL MEETING 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24421
[Presentation] ショットガンメタゲノム解析を用いた難治性肺がんマイクロバイオームの解明2023
- Author(s)
  松岡篤志、枝園和彦、大亀正義、冨田秀太、田中真、橋本好平、諏澤憲、三好健太郎、山本寛斉、岡崎幹生、杉本誠一郎、遠西大輔、豊岡伸一
- Organizer
  第64回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-23K18317
[Presentation] Periostin secreted by cancer-associated fibroblast promotes cancer progression and drug resistance in non-small cell lung cancer2022
- Author(s)
  Ken Suzawa, Shuta Tomida, Kazuhiko Shien, Hiromasa Yamamoto, and Shinichi Toyooka
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24421
[Presentation] Doublecortin-like Kinase 1 (DCLK1) correlates with the cell proliferation in malignant pleural mesothelioma2019
- Author(s)
  Akihiro Miura, Hiromasa Yamamoto, Hiroyuki Tao, Ken Suzawa, Shunsaku Miyauchi, Kota Araki, Yuta Takahashi, Eisuke Kurihara, Yusuke Ogoshi, Kazuhiko Shien, Junichi Soh, Kazunori Okabe, Shuta Tomida, Masakiyo Sakaguchi, Shinichi Toyooka
- Organizer
  AACR Annual Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09286
[Presentation] Activation of AXL as a preclinical acquired resistance mechanism against osimertinib treatment in EGFR-mutant non-small cell lung cancer cells2019
- Author(s)
  Kei Namba, Kazuhiko Shien, Yuta Takahashi, Hiroki Sato, Takahiro Yoshioka, Ken Suzawa, Hiromasa Yamamoto, Junichi Soh, Shuta Tomida, Shinichi Toyooka
- Organizer
  AACR Annual Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05431
[Presentation] Clinicopathological characteristics of lung cancer patients with concomitant idiopathic pulmonary fibrosis2019
- Author(s)
  Kota Araki, Kazuhiko Shien, Shunsaku Miyauchi, Akihiro Miura, Yuta Takahashi, Eisuke Kurihara, Yusuke Ogoshi, Kei Namba, Ken Suzawa, Hiromasa Yamamoto, Shuta Tomida, Junichi Soh, Masakiyo Sakaguchi, Shinichi Toyooka
- Organizer
  AACR Annual Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19581
[Presentation] EGFR 変異陽性肺癌における LRIG1 の抗腫瘍効果2018
- Author(s)
  鳥越英次郎、山本寛斉、阪口政清、難波圭、佐藤博紀、枝園和彦、諏澤憲、宗淳一、冨田秀太、佃和憲、三好新一郎、豊岡伸一
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08783
[Presentation] Antitumor effect of neratinib in lung cancers harboring HER2 oncogene alterations2018
- Author(s)
  Yusuke Ogoshi, shinichi Toyooka, Jyunichi Soh, hiromasa Yamamoto, Kazuhiko Shien, Hidejiro torigoe, Hiroki sato, Takahiro Yoshioka, Kei Namba, Yuta Takahashi, and Eisuke Kurihara
- Organizer
  AACR2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10681
[Presentation] Metformin improves immune function of exhausted peripheral CD8+ T cells derived from cancer patients2017
- Author(s)
  Mototsugu Watanabe, Shingo Eikawa, Kazuhiko Shien, Hiromasa Yamamoto, Tadahiko Shien, Junichi Soh, Hiroyoshi Doihara, Shinichi Toyooka, Shinichiro Miyoshi, Heiichiro Udono
- Organizer
  AACR Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15637
[Presentation] Multiple acquired resistance mechanisms against third generation EGFR-TKI osimertinib in non-small cell lung cancer cells2017
- Author(s)
  Kei Namba, Kazuhiko Shien, Hidejiro Torigoe, Hiroki Sato, Hiromasa Yamamoto, Junichi Soh, Kazunori Tsukuda, Shinichi Toyooka
- Organizer
  第58回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05431
[Presentation] Detection of multiple low-frequency mutations by molecular-barcode sequencing2017
- Author(s)
  Kei Namba, Shuta Tomida, Hidejiro Torigoe, Hiroki Sato, Kazuhiko Shien, Hiromasa Yamamoto, Junichi Soh, Kazunori Tsukuda, Shinichi Toyooka
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05431
[Presentation] 悪性胸膜中皮腫に対するREIC/Dkk-3遺伝子治療2016
- Author(s)
  山本寛斉、諏澤憲、枝園和彦、宗淳一、三好健太郎、大谷真二、杉本誠一郎、山根正修、大藤剛宏、三好新一郎、豊岡伸一
- Organizer
  第69回日本胸部外科学会定期学術集会
- Place of Presentation
  岡山
- Year and Date
  2016-09-28
- Data Source
  KAKENHI-PROJECT-26670627
[Presentation] Detection of multiple low-frequency mutations by molecular-barcode sequencing2016
- Author(s)
  Kei Namba, Shuta Tomida, Ken Suzawa, Hidejiro Torigoe, Hiroki Sato, Hiromasa Yamamoto, Junichi Soh, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
- Organizer
  IASLC 17TH WORLD CONFERENCE ON LUNG CANCER
- Place of Presentation
  Vienna, Austria
- Year and Date
  2016-12-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05431
[Presentation] Targeting miR-200c/Lin28B axis in acquired EGFR-TKI resistance non-small cell cancer cells harboring EMT features2016
- Author(s)
  Kazuhiko Shien, Hiroki Sato, Ken Suzawa, Shuta Tomida, Shinsuke Hashida, Hiromasa Yamamoto, Junichi Soh, Hidejiro Torigoe, Kei Namba, Mototsugu Watanabe, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyota
- Organizer
  World Conference on Lung Cancer 2016
- Place of Presentation
  Vienna, Austria
- Year and Date
  2016-12-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19935
[Presentation] Detection of multiple low-frequency mutations by molecular-barcode sequencing2016
- Author(s)
  Kei Namba, Shuta Tomida, Kazuhiko Shien, Hidejiro Torigoe, Hiroki Sato, Hiromasa Yamamoto, Junichi Soh, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
- Organizer
  第57回日本肺癌学会総会
- Place of Presentation
  福岡市
- Year and Date
  2016-12-19
- Data Source
  KAKENHI-PROJECT-16H05431
[Presentation] Ｔhe proof of concept of REIC/Dkk-3 gene therapy for thoracic malignancies.2016
- Author(s)
  Shinichi Toyooka, Ken Suzawa, Kazuhiko Shien, Masakiyo Sakaguchi, Masami Watanabe, Peng Huang, Kei Namba, Hidejiro Torigoe, Hiroki Sato, Junichi Soh, Hiromasa Yamamoto, Yuho Maki, Kazunori Tsukuda, Shuta Tomida, Yasutomo Nasu, Hiromi Kumon, Shinichiro Miyoshi
- Organizer
  １０ｔｈ AACR-JCA Joint Conference on Breakthroughs in Cancer Research: From Biology to Therapeutics
- Place of Presentation
  米国
- Year and Date
  2016-02-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670627
[Presentation] Cytokeratin 19 binds to HER2 and activates HER2 and its downstream signaling2016
- Author(s)
  Tomoaki Ohtsuka, Masakiyo Sakaguchi, Shuta Tomida, Hiromasa Yamamoto, Katsuyoshi Takata, Shinsuke Hashida, Mototsugu Watanabe, Ken Suzawa, Yuho Maki, Junichi Soh, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
- Organizer
  Tenth AACR-JCA Joint Conference on Breakthroughs in Cancer Research: From Biology to Therapeutics
- Place of Presentation
  Maui, Hawaii, USA
- Year and Date
  2016-02-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293318
[Presentation] 胸部悪性腫瘍に対するREIC遺伝子治療2016
- Author(s)
  豊岡伸一、諏澤憲、枝園和彦、牧佑歩、山本寛斉、宗淳一、山根正修、大藤剛宏、公文裕巳、三好新一郎
- Organizer
  第116回日本外科学会定期学術集会
- Place of Presentation
  大阪
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-26670627
[Presentation] Distant bystander effect of REIC/Dkk-3 gene therapy through immune system stimulation in a murine model of thoracic malignancies2015
- Author(s)
  Ken Suzawa, Kazuhiko Shien, Pen Huang, Masakiyo Sakaguchi, Mototsugu Watanabe, Shinsuke Hashida, Junichi Soh, Hiromasa Yamamoto, Yuho Maki, Hiroaki Asano, Kazunori Tsukuda, Yasutomo Nasu, Hiromi Kumon, Shinichiro Miyoshi, Shinichi Toyooka
- Organizer
  16th World Conference on Lung Cancer
- Place of Presentation
  名古屋
- Year and Date
  2015-09-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670627
[Presentation] Adenovirus-mediated REIC/Dkk-3 gene therapy shows indirect antitumor effects on thoracic malignancies through immune system stimulation2015
- Author(s)
  Ken Suzawa, Kazuhiko Shien, Masakiyo Sakaguchi, Masami Watanabe, Shinsuke Hashida, Junichi Soh, Hiromasa Yamamoto, Yuho Maki, Kazunori Tsukuda, Yasutomo Nasu, Hiromi Kumon, Shinichiro Miyoshi, Shinichi Toyooka
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  米国
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26670627
[Presentation] 悪性胸膜中皮腫に対するREIC/Dkk-3遺伝子治療2015
- Author(s)
  山本寛斉、枝園和彦、牧佑歩、宗淳一、大谷真二、三好健太郎、杉本誠一郎、山根正修、大藤剛宏、渡部昌実、那須保友、公文裕巳、三好新一郎、豊岡伸一
- Organizer
  第56回日本肺癌学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2015-11-26
- Data Source
  KAKENHI-PROJECT-26670627
[Presentation] Docetaxel-resitant non-small cell lung cancer cells that acquired cross-resistance to EGFR-tyrosine kinase inhibitor2015
- Author(s)
  Haiyang Chen, Ken Suzawa, Shinsuke Hashida, Tomoaki Ohtsuka, Mototsugu Watanabe, Yuho Maki, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
- Organizer
  第74回日本癌学会総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25293302
[Presentation] Identification of a novel binding protein playing a critical role in HER2 activation in lung cancer cells2015
- Author(s)
  Tomoaki Ohtsuka, Masakiyo Sakaguchi, Katsuyoshi Takata, Shinsuke Hashida, Mototsugu Watanabe, Ken Suzawa, Yuho Maki, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
- Organizer
  AACR Annual Meeting 2015
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293318
[Presentation] 悪性胸膜中皮腫に対するREIC/Dkk-3遺伝子治療2015
- Author(s)
  山本寛斉、枝園和彦、牧佑歩、宗淳一、大谷真二、三好健太郎、杉本誠一郎、山根正修、大藤剛宏、渡部昌実、那須保友、公文裕巳、三好新一郎、豊岡伸一
- Organizer
  第56回日本肺癌学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2015-11-26
- Data Source
  KAKENHI-PROJECT-25462195
[Presentation] Effect of Hsp90 inhibitor NVP-AUY922 with radiation on lung adenocarcinoma cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors2015
- Author(s)
  Yuho Maki, Shinsuke Hashida, Hiromasa Yamamoto, Kazuhiko Shien, Tomoaki Ohtsuka, Ken Suzawa, Masashi Furukawa, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Susumu Kanazawa, Shinichi Toyooka
- Organizer
  AACR 106th Annual Meeting
- Place of Presentation
  米国
- Year and Date
  2015-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293302
[Presentation] Anti-tumor effect of afatinib, an irreversible EGFR/HER2 dual inhibitor, in lung cancers harboring HER2 oncogene2015
- Author(s)
  Ken Suzawa, Shinichi Toyooka, Masakiyo Sakaguchi, Tomoaki Ohtsuka, Mototsugu Watanabe, Shinsuke Hashida, Yuho Maki, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi
- Organizer
  AACR Annual Meeting 2015
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293318
[Presentation] Anti-tumor effect of a bis-anilino pyrimidine compound TAE226 on EGFR-mutant non-small cell lung cancer cells with or without T790M mutation2015
- Author(s)
  Hiromasa Yamamoto, Hiroki Otani, Munenori Takaoka, Masakiyo Sakaguchi, Junichi Soh, Masaru Jida, Tsuyoshi Ueno, Takafumi Kubo, Hiroaki Asano, Kazunori Tsukuda, Katsuyuki Kiura, Shinji Hatakeyama, Eiji Kawahara, Yoshio Naomoto, Shinichiro Miyoshi, Shinichi Toyooka
- Organizer
  第74回日本癌学会総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25293302
[Presentation] TAE226, a bis-anilino pyrimidine compound, shows anti-tumor effect on EGFR-mutant non-small cell lung cancer cells including T790M mutant2015
- Author(s)
  Hiromasa Yamamoto, Hiroki Otani, Munenori Takaoka, Masakiyo Sakaguchi, Junichi Soh, Masaru Jida, Tsuyoshi Ueno, Takafumi Kubo, Hiroaki Asano, Kazunori Tsukuda, Katsuyuki Kiura, Shinji Hatakeyama, Eiji Kawahara, Yoshio Naomoto, Shinichiro Miyoshi, Shinichi Toyooka
- Organizer
  16th World Conference on Lung Cancer
- Place of Presentation
  米国
- Year and Date
  2015-09-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293302
[Presentation] HER2関連肺癌に対するアファチニブの抗腫瘍効果2015
- Author(s)
  諏澤　　憲，豊岡　伸一，大塚　智昭，渡邉　元嗣，橋田　真輔，牧　　佑歩，山本　寛斉，宗　　淳一，岡田　真典，伊賀　徳周，三好健太郎，杉本誠一郎，山根　正修，大藤　剛宏，三好新一郎
- Organizer
  第58回関西胸部外科学会学術集会
- Place of Presentation
  岡山
- Year and Date
  2015-06-12
- Data Source
  KAKENHI-PROJECT-26293318
[Presentation] The molecular characters of acquired resistant non-small cell lung cancer cells to afatinib2014
- Author(s)
  Shinsuke Hashida, Shinichi Toyooka, Tomoaki Ohtsuka, Ken Suzawa, Kazuhiko Shien, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda,Shinichiro Miyoshi
- Organizer
  AACR Annual Meeting 2014
- Place of Presentation
  San Diego, California, U.S.A
- Data Source
  KAKENHI-PROJECT-25293302
[Presentation] The molecular characters of acquired resistant non－small cell lung cancer cells to afatinib
- Author(s)
  Shinsuke Hashida, Shinichi Toyooka, Tomoaki Ohtsuka, Ken Suzawa, Kazuhiko Shien, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyosh
- Organizer
  AACR Annual Meeting 2014
- Place of Presentation
  San Diego, California, U.S.A
- Year and Date
  2014-04-05 – 2014-04-09
- Data Source
  KAKENHI-PROJECT-25293302
[Presentation] Anti-tumor effect of afatinib, an irreversible EGFR/HER2 dual inhibitor, in lung cancers harboring HER2 oncogene
- Author(s)
  Ken Suzawa, Shinichi Toyooka, Masakiyo Sakaguchi, Tomoaki Ohtsuka, Mototsugu Watanabe, Shinsuke Hashida, Yuho Maki, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi
- Organizer
  AACR Annual Meeting 2015
- Place of Presentation
  Philadelphia, PA, USA
- Year and Date
  2015-04-18 – 2015-04-22
- Data Source
  KAKENHI-PROJECT-26293318
[Presentation] 新規HER2膜貫通部領域遺伝子変異の機能解析
- Author(s)
  諏澤憲、阪口政清、山本寛斉、宗淳一、牧佑歩、橋田真輔、大塚智昭、渡邉元嗣、浅野博昭、佃和憲、三好新一郎、豊岡伸一
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26293318
[Presentation] Effect of Hsp90 inhibitor NVP-AUY922 with radiation on lung adenocarcinoma cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors
- Author(s)
  Yuho Maki, Shinsuke Hashida, Hiromasa Yamamoto, Kazuhiko Shien, Tomoaki Ohtsuka, Ken Suzawa, Masashi Furukawa, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Susumu Kanazawa, Shinichi Toyooka.
- Organizer
  AACR Annual Meeting 2015
- Place of Presentation
  Philadelphia, PA, USA
- Year and Date
  2015-04-18 – 2015-04-22
- Data Source
  KAKENHI-PROJECT-24791462

1. Toyooka Shinichi (30397880)

# of Collaborated Projects: 26 results

# of Collaborated Products: 58 results
2. 諏澤憲 (90839713)

# of Collaborated Projects: 19 results

# of Collaborated Products: 22 results
3. Tomida Shuta (10372111)

# of Collaborated Projects: 18 results

# of Collaborated Products: 25 results
4. SOH Junichi (90559890)

# of Collaborated Projects: 13 results

# of Collaborated Products: 38 results
5. SHIEN Kazuhiko (30708079)

# of Collaborated Projects: 13 results

# of Collaborated Products: 17 results
6. 阪口政清 (70379840)

# of Collaborated Projects: 9 results

# of Collaborated Products: 16 results
7. MIYOSHI Shinichiro (00190827)

# of Collaborated Projects: 7 results

# of Collaborated Products: 18 results
8. TSUKUDA Kazunori (20346430)

# of Collaborated Projects: 5 results

# of Collaborated Products: 16 results
9. ASANO Hiroaki (70534775)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
10. 冨樫庸介 (80758326)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
11. 遠西大輔 (20825096)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
12. Okazaki Mikio (50467750)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
13. 大橋圭明 (60729193)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. OHTSUKA Tomoaki

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
15. MATSUDA Fumihiko (50212220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. Shien Tadahiko (30509451)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. Maki Yuho (20549878)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 片山博志 (90713975)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 光冨徹哉 (70209807)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 須田健一 (30631593)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 宮原信明 (70335610)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 山下素弘 (40284103)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 大谷真二 (10770779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 山根正修 (20432643)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
25. 坂上倫久 (20709266)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
26. 木下理恵 (40518297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
27. 杉本誠一郎 (40570148)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
28. 山本英喜 (10581697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
29. 江口傑徳 (20457229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 加藤竜司 (50377884)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 本田知之 (80402676)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 土生智大 (00974859)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 匹田貴夫 (00437005)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 中山雅敬 (70740918)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 中田英二 (10649304)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 細野祥之 (60820363)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 山中玲子 (00379760)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 伊達慶一 (30974860)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. CHEN Haiyang

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
40. WATANABE Masami

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 村田等

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 橘逸勢

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. 山本健一

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

Yamamoto Hiromasa 山本 寛斉

YAMAMOTO Hiromasa 山本 寛斉

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Clarification of spatiotemporal diversity in tumor microenvironment promoting lung metastases from bone and soft tissue sarcomaPrincipal Investigator

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Exploration of the novel therapeutic target for lung cancer based on the analysis of the characteristics of tumor cells derived from 3D culturePrincipal Investigator

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Yamamoto Hiromasa 山本寛斉

YAMAMOTO Hiromasa 山本寛斉