SAKAMOTO Toshihisa 阪本敏久

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阪本敏久

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Researcher Number	50178571
Affiliation (based on the past Project Information) *help	2015: 防衛医科大学校, その他部局等, 教授 2015: 防衛医科大学校病院, 救急部, 部長 2014 – 2015: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, その他部局等, 教授 2011 – 2014: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 病院, 教授 2012: 防衛医科大学校, 病院, 教授 1986: 大阪大学, 医学部, 助手
Review Section/Research Field	Except Principal Investigator Emergency medicine / General surgery / Integrated Nutrition Science / Bacteriology (including Mycology)
Keywords	Except Principal Investigator クッパー細胞 / レスベラトロール / 活性酸素 / Pituitary gland / Kidney / Liver / Heart / Epinephrine / Arginine vasopressin / Brain death … More / 循環動態 / 骨髄機能 / 膵機能 / 腎機能 / 肝機能 / 心機能 / 抗利尿ホルモン(ADH) / 病理 / 脳下垂体 / 腎臓 / 肝臓 / 心臓 / エピネフリン / 抗利尿ホルモン / 脳死 / 脂肪滴 / ADFP / 脂肪肝 / 合成CRP / グルココルチコイド受容体 / 核内受容体 / ナノ医学 / 重症感染症 / エンドトキシントレランス / 光線力学療法 / 止血ナノ粒子 / ナノシート / ursodepxycolic acid / 外科侵襲 / compromised hosts / MKN45 / cell proliferation / Proteus mirabillis / 胃がん細胞 / 胃内起因菌 / Helicobacter pylori / 病原性 / NK細胞 / 細菌感染 / マウス熱傷モデル / 免疫不全 / CD11b陽性Kupffer細胞 / CD68陽性Kupffer細胞 / CD11b陽性クッパー細胞 / CD68陽性クッパー細胞 / IL-18 / 熱傷後感染 / 好中球 / 複合免疫不全 / 熱傷 Less

Management against surgical stress in compromised hosts
- Principal Investigator
  
  Kinoshita Manabu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Emergency medicine
- Research Institution
  National Defense Medical College
Resveratrol ameliorates high-fat-diet-induced fatty liver by increasing CD68 positive Kupffer cells.
- Principal Investigator
  
  Nishikawa Kahoko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrated Nutrition Science
- Research Institution
  Chuo University
  National Defense Medical College
Bacterial pathogen Helicobacter pylori may augment gene expressions of TLR4 and TLR5 on cancer cells under coexistence with another gastric bacteria Proteus mirabilis
- Principal Investigator
  
  NISHIKAWA Kahoko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  防衛医科大学校
   National Defense Medical College
Mechanical analyses and treatment of immunodeficiency following burn injury
- Principal Investigator
  
  KINOSHITA Manabu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  National Defense Medical College
Changes of heart, liver, kidney and endocrine glands in brain death.
- Principal Investigator
  
  SUGIMOTO Tsuyoshi
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Department of Traumatology, Osaka University Hospital

All 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Resveratrol increases CD68+ Kupffer cells colocalized with adipose differentiation-related protein and ameliorates high-fat-diet-induced fatty liver in mice.2015
- Author(s)
  Nishikawa K, Iwaya K, Kinoshita M, Fujiwara Y, Akao M, Sonoda M, Thiruppathi S, Suzuki T, Hiroi S, Seki S, Sakamoto T.
- Journal Title
  
  Mol Nutr Food Res
  
  Volume: 12 Issue: 6 Pages: 564-564
- DOI
  10.1002/mnfr.201400564
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590457, KAKENHI-PROJECT-25504021, KAKENHI-PROJECT-25460508, KAKENHI-PROJECT-25293369
[Journal Article] Noradrenalin effectively rescues mice from blast lung injury caused by laser-induced shock waves.2015
- Author(s)
  Miyawaki H, Saito D, Hagisawa K, Noguchi M, Sato S, Kinoshita M, Miyazaki H, Sato Y, Harada N, Sakamoto T.
- Journal Title
  
  Intensive Care Medicine Experimental
  
  Volume: 32 Issue: 1 Pages: 32-32
- DOI
  10.1186/s40635-015-0069-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25462843, KAKENHI-PROJECT-25293369
[Journal Article] Detection of changes in the structure and distribution map of triacylglycerol in fatty liver model by MALDI-Spiral TOF2014
- Author(s)
  Nishikawa K, Hashimoto M, Itoh Y, Hiroi S, Kusai A, Hirata F, Sakamoto T, Iwaya K
- Journal Title
  
  FEBS Open Bop
  
  Volume: 19 Issue: 1 Pages: 179-84
- DOI
  10.1016/j.fob.2014.02.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590457, KAKENHI-PROJECT-25504021
[Journal Article] 人工血小板H12(ADP)リポソームを用いた急性血小板減少病態への止血・救命対策.2013
- Author(s)
  西川可穂子、萩沢康介、柳川錬平、土井麻実、鈴木英紀、齋藤大蔵、阪本敏久、武岡真司、半田誠、木下学
- Journal Title
  
  人工血液
  
  Volume: 21 Pages: 60-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293369
[Journal Article] Fibrinogen γ-chain peptide-coated, adenosine diphosphate-encapsulated liposomes rescue thrombocytopenic rabbits from non-compressible liver hemorrhage2012
- Author(s)
  Nishikawa K, Hagisawa K, Kinoshita M, Shono S, Katsuno S, Doi M, Yanagawa R, Suzuki H, Iwaya K, Saitoh D, Sakamoto T, Seki S, Takeoka S, Handa M
- Journal Title
  
  J Thromb Haemost
  
  Volume: 10 Pages: 2137-2148
- Data Source
  KAKENHI-PROJECT-22592027
[Presentation] Resveratrol increases cd68+kupffer cells co-localized with adipose differentiation-related protein (adfp) and ameliorates high-fat-diet-induced fatty liver in mice.2015
- Author(s)
  K Nishikawa, K .Iwaya, M Knoshita, Y Fujiwara, S Thiuppathi, T Suzuki, S Seki, T Sakamoto
- Organizer
  4th European Congress of Immunology 2015
- Place of Presentation
  ウィーン　（オーストリア　）
- Year and Date
  2015-09-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25504021
[Presentation] Resveratrol increases CD68 positive Kupffer cells with phagocytic activity to lipid droplets and ameliorates high-fat diet induced fatty liver in mice2013
- Author(s)
  Nishikawa K, Kinoshita M, Iwaya K, Sakamoto T, Seki S.
- Organizer
  第42回日本免疫学会総会
- Place of Presentation
  幕張（千葉）
- Data Source
  KAKENHI-PROJECT-25504021
[Presentation] 食餌性レスベラトロールが肝臓に蓄積する中性脂肪へ与える影響2013
- Author(s)
  西川可穂子、橋本将弘、久保歩、阪本敏久、岩屋啓一
- Organizer
  第67回日本栄養・食糧学会大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-25504021
[Presentation] Resveratrol ameliorates fatty liver by reducing the size of lipid droplet without changing liver fat species.
- Author(s)
  K. Nishikawa, M. Hashimoto, Y. Itoh, S. Hiroi, T.Sakamoto, K. Iwaya
- Organizer
  FEBS EMBO 2014 Conference
- Place of Presentation
  Palais des Congrès, Paris, France
- Year and Date
  2014-08-30 – 2014-09-04
- Data Source
  KAKENHI-PROJECT-25504021

1. KINOSHITA Manabu (70531391)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
2. ONO Satoshi (30531355)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
3. NISHIKAWA Kahoko (20345416)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
4. SEKI Shuhji (80531392)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
5. SAITOH Daizoh (90531632)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
6. MIYAZAKI Hiromi (30531636)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. SHINOMIYA Nariyoshi (40505260)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Tanaka Yuji (50221396)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Morimoto Yuji (10449069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Takahashi Tetsuya (00589905)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Nakashima Hiroyuki (10574064)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Hagisawa Kosuke (50539244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. Hinoki Akinari (90383257)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Takeoka Shinji (20222094)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Handa Makoto (40129614)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. Iwaya Keiichi (50312012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
17. Fujiwara Yoko (50293105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. SUGIMOTO Tsuyoshi (10028342)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. KINOSHITA Yoshihiro (30195341)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. UENISHI Masaaki (90176610)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. SUGIMOTO Hisashi (90127241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. YOSHIOKA Toshiharu (60127313)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 横田順一朗 (10166879)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 渋谷正徳 (90187419)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. ISHIKAWA Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
26. 小田美規

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 土田英俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 佐藤俊一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SAKAMOTO Toshihisa 阪本 敏久

阪本 敏久

Research Projects

Research Products

Co-Researchers

Management against surgical stress in compromised hosts

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Resveratrol ameliorates high-fat-diet-induced fatty liver by increasing CD68 positive Kupffer cells.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Bacterial pathogen Helicobacter pylori may augment gene expressions of TLR4 and TLR5 on cancer cells under coexistence with another gastric bacteria Proteus mirabilis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanical analyses and treatment of immunodeficiency following burn injury

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Changes of heart, liver, kidney and endocrine glands in brain death.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Resveratrol increases CD68+ Kupffer cells colocalized with adipose differentiation-related protein and ameliorates high-fat-diet-induced fatty liver in mice.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Noradrenalin effectively rescues mice from blast lung injury caused by laser-induced shock waves.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Detection of changes in the structure and distribution map of triacylglycerol in fatty liver model by MALDI-Spiral TOF2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 人工血小板H12(ADP)リポソームを用いた急性血小板減少病態への止血・救命対策.2013

Author(s)

Journal Title

Data Source

[Journal Article] Fibrinogen γ-chain peptide-coated, adenosine diphosphate-encapsulated liposomes rescue thrombocytopenic rabbits from non-compressible liver hemorrhage2012

Author(s)

Journal Title

Data Source

[Presentation] Resveratrol increases cd68+kupffer cells co-localized with adipose differentiation-related protein (adfp) and ameliorates high-fat-diet-induced fatty liver in mice.2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Resveratrol increases CD68 positive Kupffer cells with phagocytic activity to lipid droplets and ameliorates high-fat diet induced fatty liver in mice2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 食餌性レスベラトロールが肝臓に蓄積する中性脂肪へ与える影響2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Resveratrol ameliorates fatty liver by reducing the size of lipid droplet without changing liver fat species.

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

SAKAMOTO Toshihisa 阪本敏久

阪本敏久