Ohtani Naoko 大谷直子

… Alternative Names

OHTANI Naoko 大谷直子

藤田直子フジタナオコ

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Researcher Number	50275195
Other IDs
Affiliation (Current)	2025: 大阪公立大学, 大学院医学研究科, 教授
Affiliation (based on the past Project Information) *help	2022 – 2025: 大阪公立大学, 大学院医学研究科, 教授 2017 – 2021: 大阪市立大学, 大学院医学研究科, 教授 2016: 東京理科大学, 理工学部応用生物科学科, 教授 2014 – 2015: 東京理科大学, 理工学部, 教授 2013: 公益財団法人がん研究会, がん研究所, 主任研究員 … More 2013: 公益財団法人がん研究会, がん研究所がん生物部, 主任研究員 2012: 公益財団法人がん研究会, がん研究所がん生物部, 主任研究員 2011: 公益財団法人がん研究会, がん研究所・がん生物部, 主任研究員 2010: Japanese Foundation For Cancer Research, 癌研究所がん生物部, 主任研究員 2010: 財団法人癌研究会, 癌研究所がん生物部, 主任研究員 2009: Japanese Foundation For Cancer Research, 主任研究員 2009: Japanese Foundation For Cancer Research, 財団法人癌研究所, 主任研究員 2008: Japanese Foundation For Cancer Research, がん生物部, 主任研究員 2008: (財)癌研究会, 癌研究所, 主任研究員 2008: Japanese Foundation For Cancer Research, 癌研究所がん生物部, 主任研究員 2007 – 2008: The University of Tokushima, Institute For Genome Research, Associate Professor 2004 – 2006: 徳島大学, ゲノム機能研究センター, 助教授 1998: 京都府立医大, 医学部, 助手 1997: 京都府立医科大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Basic Section 59040:Nutrition science and health science-related / Tumor biology / Basic Section 59020:Sports sciences-related / Applied health science / Dermatology / Carcinogenesis / Applied health science / Ophthalmology Except Principal Investigator Basic Section 59040:Nutrition science and health science-related … More / Dermatology / Broad Section I / Basic Section 54020:Connective tissue disease and allergy-related / Basic Section 58020:Hygiene and public health-related: including laboratory approach / Gastroenterology / Biological Sciences / Biological Sciences / Hygiene Less
Keywords	Principal Investigator 運動 / がん微小環境 / 肥満 / 炎症性サイトカイン / 細胞老化 / イメージング / がん予防 / 肝がん / p16 / p21 … More / メタボライト / 肥満誘導性肝がん / SASP / 肝星細胞 / 肥満関連肝がん / 制御性T細胞 / IL-33 / 細胞老化随伴分泌現象 / 臓器連関 / 肥満誘導性肝癌 / 規則的運動 / skin cancer / bioluminescence in vivo imaging / p16^<INK4a> gene / BAC / 可視化 / p16^<Ink4a>遺伝子 / 皮膚癌 / p16^<INK4a>遺伝子 / 癌微小環境 / 炎症とがん / メタボリックストレス / p21^<Waf1/Cip1> / p16^<INK4a> / 慨日リズム / RB / p53 / 発癌 / 概日リズム / 生活習慣病 / 発現 / メチル化 / RB遺伝子 / 網膜芽細胞腫 … More Except Principal Investigator SIRT1 / 炎症 / Nox organizer 1 / NADPH oxidase 1 / 老化 / 免疫染色 / 脂漏性角化症 / 日光角化症 / 有棘細胞癌 / 発がん / 腫瘍免疫 / 非自己抗原 / 免疫監視 / 自己抗原 / 免疫寛容 / 動物モデル / 全身性エリテマトーデス / 脊椎関節炎 / 腸内細菌 / autoimmune diseases / Gut microbiome / プロバイオティクス / 炎症性サイトカイン / 線虫 / 炎症性腸疾患 / 分散接着性大腸菌 / 生菌製剤 / 炎症抑制 / 肝臓癌 / 脂肪肝炎 / XOR / 肝発がん / 脂肪肝 / ミトコンドリア / immunohistochemical analysis / cell cycle / seborrheic keratosis / actinic keratosis / Bowen's disease / basal cell carcinoma / squamous cell carcinoma / p27 / 細胞周期関連遺伝子 / ボーエン病 / 基底細胞癌 / tumor necrosis factor-alpha / Carcinogenesis / Inflammation / Innate immunity / Gastrointestinal mucosa / Gene-targeted mice / TNF-α / 自然免疫応答 / 消化管粘膜 / 遺伝子改変マウス / 感染応答 / 巨核球 / ニッチ / メタボロミクス / in vivoイメージング / SASP / ストレス応答 / 低酸素 / 単一細胞トランスクリプトーム解析 / メタボローム解析 / 幹細胞代謝 / 幹細胞ニッチ / 造血幹細胞 / γ-H2AX / セネッセンス / FGFR3 / HICl / p53 / 細胞老化 / 癌細胞 / エピジェネティクス / 表皮角化細胞 / 皮膚腫瘍学 / 癌抑制 / 細胞周期 / CRM1 / LMP1 / EBウイルス / RB / p16^<INK4a> / 化学予防 / DNA修復 / gadd45 / ケルセチン / 紫外線 / Δ^<12>-プロスタグランディンJ_2 / プロモーター / gadd45遺伝子 Less

Mechanistic Analysis of the Establishment and Breakdown of the Immune System Recognition Dogma Against Non-Self
- Principal Investigator
  
  西川博嘉
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section I
- Research Institution
  Nagoya University
Biomarker development for fatty hepatitis/liver cancer diagnosis targeting xanthine oxidoreductase (XOR)
- Principal Investigator
  
  藤井英樹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Osaka Metropolitan University
腸内細菌の形質変化に着目したリウマチ性疾患の病態解明
- Principal Investigator
  
  橋本求
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Osaka Metropolitan University
Liver cancer suppression by regular exercise: Focusing on the degradation of oncometabolitePrincipal Investigator
- Principal Investigator
  
  大谷直子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Osaka Metropolitan University
Clarify the role of mitochondria function on the development of fatty liver and hepatic carcinogenesis by targeting Apop-1
- Principal Investigator
  
  FUKUO Keisuke
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Mukogawa Women's University
分散接着性大腸菌による腸炎抑制メカニズム解明とプロバイオティクスへの応用
- Principal Investigator
  
  中台枝里子 (鹿毛枝里子)
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kyoto University
  Osaka Metropolitan University
  Osaka City University
The molecular mechanism of the inhibitory effect of liver cancer development via inter-organ relationship by regular exercise: its application to cancer preventionPrincipal Investigator
- Principal Investigator
  
  Ohtani Naoko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Osaka City University
The mechanism of obesity-associated liver cancer progression through cytokine cross-talk in tumor microenvironment.Principal Investigator
- Principal Investigator
  
  Ohtani Naoko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Osaka City University
  Tokyo University of Science
The effect of regular exercise on obesity-associated liver cancer from the aspect of gut microbiota and lipid metabolitesPrincipal Investigator
- Principal Investigator
  
  Ohtani Naoko
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied health science
- Research Institution
  Tokyo University of Science
Aging and anti-aging mechanisms in niche-hematopoietic stem cell interaction
- Principal Investigator
  
  TAKUBO Keiyo
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Center for Global Health and Medicine
The molecular mechanism of senescence-associated prolongation of inflammatory signaling and its effect on cancer micro-environments.Principal Investigator
- Principal Investigator
  
  OHTANI Naoko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Carcinogenesis
- Research Institution
  Japanese Foundation for Cancer Research
メタボリックストレス応答におけるCDKインヒビターの役割Principal Investigator
- Principal Investigator
  
  大谷直子
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Japanese Foundation For Cancer Research
分子イメージングを利用したCDKインヒビターp21の生体内機能の解明Principal Investigator
- Principal Investigator
  
  大谷直子
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Japanese Foundation For Cancer Research
Mechanism of Tumor formation by deregulated circadian rhythm and strategy for its preventionPrincipal Investigator
- Principal Investigator
  
  OHTANI Naoko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied health science
- Research Institution
  Japanese Foundation For Cancer Research
The regulation and abnormalities of the epigenetics on epidermal keratinocytes
- Principal Investigator
  
  KUBO Yoshiaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  The University of Tokushima
Analysis and pathophysiology of dysregulated expression of the Noxl gene using Noxl knockout mice
- Principal Investigator
  
  ROKUTAN Kazuhito
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokushima
Molecular abnormalities of cell cycle regulations in epidermal keratinocytes for the clinical applications
- Principal Investigator
  
  KUBO Yoshiaki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  The University of Tokushima
EBウイルスLMP1癌蛋白によるp16^<INK4a>/RB経路阻害機構の解明
- Principal Investigator
  
  HARA Eiji
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
Induction of p16^<INK4a> gene expression by oncogenic stress is involved in the tumor suppression mechanism of skin cancerPrincipal Investigator
- Principal Investigator
  
  OHTANI Naoko
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  University of Tokushima
網膜芽細胞腫におけるRB遺伝子の過剰メチル化による失活機構の解明Principal Investigator
- Principal Investigator
  
  藤田直子
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Ophthalmology
- Research Institution
  Kyoto Prefectural University of Medicine
DNA修復遺伝子gadd45の誘導物質の検索-新しい化学予防物質の検索法の確立に向けて-
- Principal Investigator
  
  酒井敏行
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hygiene
- Research Institution
  Kyoto Prefectural University of Medicine

[Book] 消化器疾患の最新医療　トピックス　腸内細菌と消化器がん2018
- Author(s)
  田尻久雄（編集顧問）大谷直子（分担執筆）
- Total Pages
  485
- Publisher
  寺田国際事務所/先端医療技術研究所
- ISBN
  9784925089616
- Data Source
  KAKENHI-PROJECT-16H04699
[Book] Chronic Inflammation (Msayuki Miyasaka and Kiyoshi Takatsu Editors) Part III No 15. Cellular Senescence as a Novel Mechanism of Chronic Inflammation and Cancer Progression2016
- Author(s)
  Naoko Ohtani
- Total Pages
  702
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-15K12709
[Book] Chronic Inflammation (Msayuki Miyasaka and Kiyoshi Takatsu Editors) Part III No 15. Cellular Senescence as a Novel Mechanism of Chronic Inflammation and Cancer Progression2016
- Author(s)
  Naoko Ohtani
- Total Pages
  702
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-16H04699
[Book] 組織幹細胞の老化(佐方功幸、稲垣昌樹、岸本武雄編集)(細胞周期フロンティア)2010
- Author(s)
  大谷直子執筆担当
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-20300229
[Journal Article] Visualization of hydrocarbon chain length and degree of saturation of fatty acids in mouse livers by combining near-infrared hyperspectral imaging and machine learning2023
- Author(s)
  Mori Akino、Umezawa Masakazu、Okubo Kyohei、Kamiya Tomonori、Kamimura Masao、Ohtani Naoko、Soga Kohei
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1
- DOI
  10.1038/s41598-023-47565-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03369
[Journal Article] Bacterial induction of B cell senescence promotes age-related changes in the gut microbiota2023
- Author(s)
  Kawamoto Shimpei、Uemura Ken、Hori Nozomi、Takayasu Lena、Konishi Yusuke、Katoh Kazutaka、Matsumoto Tomonori、Suzuki Masae、Sakai Yusuke、Matsudaira Tatsuyuki、Adachi Takahiro、Ohtani Naoko、Standley Daron M.、Suda Wataru、Fukuda Shinji、Hara Eiji
- Journal Title
  
  Nature Cell Biology
  
  Volume: 25 Issue: 6 Pages: 865-876
- DOI
  10.1038/s41556-023-01145-5
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06481, KAKENHI-PROJECT-22H00457, KAKENHI-PROJECT-21H03369, KAKENHI-PROJECT-23K24798
[Journal Article] CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance2023
- Author(s)
  Takasugi Masaki、Ohtani Naoko、Takemura Kazuaki、Emmrich Stephan、Zakusilo Frances T.、Yoshida Yuya、Kutsukake Nobuyuki、Mariani John N.、Windrem Martha S.、Chandler-Militello Devin、Goldman Steven A.、Satoh Junko、Ito Shinji、Seluanov Andrei、Gorbunova Vera
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 9 Pages: 113130-113130
- DOI
  10.1016/j.celrep.2023.113130
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K10963, KAKENHI-PROJECT-21H03369
[Journal Article] Nitric Oxide Derived from Cytoglobin-Deficient Hepatic Stellate Cells Causes Suppression of Cytochrome c Oxidase Activity in Hepatocytes2023
- Author(s)
  Yoshinori Okina, Misako Sato-Matsubara, Yasutoshi Kido, Hayato Urushima, Atsuko Daikoku, Chiho Kadono, Yu Nakagama, Yuko Nitahara, Truong Huu Hoang, Le Thi Thanh Thuy, Tsutomu Matsubara, Naoko Ohtani, Kazuo Ikeda, Katsutoshi Yoshizato, Norifumi Kawada.
- Journal Title
  
  Antioxid Redox Signal.
  
  Volume: 38 Pages: 463-479
- DOI
  10.1089/ars.2021.0279
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07968, KAKENHI-PROJECT-22K08083, KAKENHI-PROJECT-20H00335, KAKENHI-PROJECT-21H03369, KAKENHI-PROJECT-23K21359, KAKENHI-PROJECT-21K06757, KAKENHI-PROJECT-20K16226, KAKENHI-PROJECT-23K24322
[Journal Article] Gene expressions associated with longer lifespan and aging exhibit similarity in mammals2023
- Author(s)
  Takasugi Masaki、Yoshida Yuya、Nonaka Yoshiki、Ohtani Naoko
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 51 Issue: 14 Pages: 7205-7219
- DOI
  10.1093/nar/gkad544
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23KJ1831, KAKENHI-PROJECT-21H03369
[Journal Article] Oral Microbial Profile Analysis in Patients with Oral and Pharyngeal Cancer Reveals That Tumoral Fusobacterium nucleatum Promotes Oral Cancer Progression by Activating YAP2023
- Author(s)
  Yamamoto Yuki、Kamiya Tomonori、Yano Megumu、Huyen Vu Thuong、Oishi Masahiro、Nishio Miki、Suzuki Akira、Sunami Kishiko、Ohtani Naoko
- Journal Title
  
  Microorganisms
  
  Volume: 11 Issue: 12 Pages: 2957-2957
- DOI
  10.3390/microorganisms11122957
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04806, KAKENHI-PROJECT-21H03369
[Journal Article] Recent updates on the role of the gut-liver axis in the pathogenesis of NAFLD/NASH, HCC, and beyond2023
- Author(s)
  Ohtani Naoko、Kamiya Tomonori、Kawada Norifumi
- Journal Title
  
  Hepatology Communications
  
  Volume: 7 Issue: 9
- DOI
  10.1097/hc9.0000000000000241
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03369, KAKENHI-PROJECT-23K24322
[Journal Article] Cytoglobin attenuates pancreatic cancer growth via scavenging reactive oxygen species2022
- Author(s)
  Hoang Dinh Viet、Thuy Le Thi Thanh、Hai Hoang、Hieu Vu Ngoc、Kimura Kenjiro、Oikawa Daisuke、Ikura Yoshihiro、Dat Ninh Quoc、Hoang Truong Huu、Sato-Matsubara Misako、Dong Minh Phuong、Hanh Ngo Vinh、Uchida-Kobayashi Sawako、Tokunaga Fuminori、Kubo Shoji、Ohtani Naoko、Yoshizato Katsutoshi、Kawada Norifumi
- Journal Title
  
  Oncogenesis
  
  Volume: 11 Issue: 1 Pages: 1-13
- DOI
  10.1038/s41389-022-00389-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06873, KAKENHI-PROJECT-21K07921, KAKENHI-PROJECT-21K07968, KAKENHI-PROJECT-22K08083, KAKENHI-PROJECT-22K18385, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H02688, KAKENHI-PROJECT-21H03369, KAKENHI-PUBLICLY-21H00291, KAKENHI-PROJECT-23K24322
[Journal Article] Cancer cells produce liver metastasis via gap formation in sinusoidal endothelial cells through proinflammatory paracrine mechanisms.2022
- Author(s)
  Huu Hoang T, Sato-Matsubara M, Yuasa H, Matsubara T, Thuy LTT, Ikenaga H, Phuong DM, Hanh NV, Hieu VN, Hoang DV, Hai H, Okina Y, Enomoto M, Tamori A, Daikoku A, Urushima H, Ikeda K, Dat NQ, Yasui Y, Shinkawa H, Kubo S, Yamagishi R, Ohtani N, Yoshizato K, Gracia-Sancho J, Kawada N.
- Journal Title
  
  Sci Adv.
  
  Volume: 8(39) Issue: 39 Pages: 5525-5525
- DOI
  10.1126/sciadv.abo5525
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06757, KAKENHI-PROJECT-21K07968, KAKENHI-PROJECT-21K07990, KAKENHI-PROJECT-22K08083, KAKENHI-PROJECT-20K16226, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-21H03369, KAKENHI-PROJECT-23K21359, KAKENHI-PROJECT-23K24322
[Journal Article] Characterization of Transcriptomic and Proteomic Changes in the Skin after Chronic Fluocinolone Acetonide Treatment2022
- Author(s)
  Choi Y, Takasugi M, Takemura K, Yoshida Y, Kamiya T, Adachi J, Tsuruta D, Ohtani N
- Journal Title
  
  Biomolecules
  
  Volume: 12 Issue: 12 Pages: 1822-1822
- DOI
  10.3390/biom12121822
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03369
[Journal Article] Non-heat-stressed Method to Isolate Hepatic Stellate Cells From Highly Steatotic Tumor-bearing Liver Using CD49a2022
- Author(s)
  Yi Cheng, Ryota Yamagishi, Yoshiki Nonaka, Misako Sato-Matsubara, Norifumi Kawada, Naoko Ohtani
- Journal Title
  
  Cellular and molecular gastroenterology and hepatology
  
  Volume: 14 Issue: 4 Pages: 964-966.e9
- DOI
  10.1016/j.jcmgh.2022.07.006
- URL
  https://ocu-omu.repo.nii.ac.jp/records/2019707
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07968, KAKENHI-PROJECT-21H03369, KAKENHI-PROJECT-20K16309
[Journal Article] The role of cellular senescence and SASP in tumour microenvironment2022
- Author(s)
  Takasugi M, Yoshida Y, Hara E, Ohtani N
- Journal Title
  
  FEBS J
  
  Volume: 290 Issue: 5 Pages: 1348-1361
- DOI
  10.1111/febs.16381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H03369
[Journal Article] Distinct responsiveness to rifaximin in patients with hepatic encephalopathy depends on functional gut microbial species2022
- Author(s)
  Yukawa-Muto Y, Kamiya T, Fujii H, Mori H, Toyoda A, Sato I, Konishi Y, Hirayama A, Hara E, Fukuda S, Kawada N, Ohtani N
- Journal Title
  
  Hepatol Commun
  
  Volume: 6 Issue: 8 Pages: 2090-2104
- DOI
  10.1002/hep4.1954
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03369, KAKENHI-PROJECT-20K16121
[Journal Article] Soluble Immune Checkpoint Protein CD27 Is a Novel Prognostic Biomarker of Hepatocellular Carcinoma Development in Hepatitis C Virus?Sustained Virological Response Patients2022
- Author(s)
  Dong Minh Phuong、Thuy Le Thi Thanh、Hoang Dinh Viet、Hai Hoang、Hoang Truong Huu、Sato-Matsubara Misako、Hieu Vu Ngoc、Daikoku Atsuko、Hanh Ngo Vinh、Urushima Hayato、Dat Ninh Quoc、Uchida-Kobayashi Sawako、Enomoto Masaru、Ohtani Naoko、Tamori Akihiro、Kawada Norifumi
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 192 Issue: 10 Pages: 1379-1396
- DOI
  10.1016/j.ajpath.2022.07.003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07921, KAKENHI-PROJECT-21K07990, KAKENHI-PROJECT-22K08083, KAKENHI-PROJECT-20K16226, KAKENHI-PROJECT-21H03369, KAKENHI-PROJECT-23K24322
[Journal Article] The roles and mechanisms of senescence-associated secretory phenotype (SASP): can it be controlled by senolysis?2022
- Author(s)
  Ohtani N
- Journal Title
  
  Inflamm Regen
  
  Volume: 42 Issue: 1 Pages: 11-11
- DOI
  10.1186/s41232-022-00197-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H03369
[Journal Article] The role of immune cells in the liver tumor microenvironment: an involvement of gut microbiota-derived factors.2022
- Author(s)
  Kamiya T, Ohtani N
- Journal Title
  
  Int Immunol
  
  Volume: 34 Issue: 9 Pages: 467-474
- DOI
  10.1093/intimm/dxac020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H03369
[Journal Article] Gasdermin D-mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma2022
- Author(s)
  Yamagishi R, Kamachi F, Nakamura M, Yamazaki S, Kamiya T, Takasugi M, Cheng Y, Nonaka Y, Yukawa-Muto Y, Thuy LTT, Harada Y, Arai T, Loo TM, Yoshimoto S, Ando T, Nakajima M, Taguchi H, Ishikawa T, Akiba H, Miyake S, Kubo M, Iwakura Y, Fukuda S, Chen WY, Kawada N, Rudensky A, Nakae S, Hara E, Ohtani N
- Journal Title
  
  Science Immunology
  
  Volume: 7 Issue: 72 Pages: abl7209
- DOI
  10.1126/sciimmunol.abl7209
- URL
  https://ocu-omu.repo.nii.ac.jp/records/2020472
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08083, KAKENHI-PROJECT-22H00457, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-20H03472, KAKENHI-PROJECT-21H02964, KAKENHI-PROJECT-21H03369, KAKENHI-PROJECT-20K16309, KAKENHI-PROJECT-23K24322
[Journal Article] Development and evaluation of a colorectal cancer screening method using machine learning-based gut microbiota analysis2022
- Author(s)
  Konishi Y, Okumura S, Matsumoto T, Itatani Y, Nishiyama T, Okazaki Y, Shibutani M, Ohtani N, Nagahara H, Obama K, Ohira M, Sakai Y, Nagayama S, Hara E
- Journal Title
  
  Cancer Med
  
  Volume: 11 Issue: 16 Pages: 3194-3206
- DOI
  10.1002/cam4.4671
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03369
[Journal Article] Cellular senescence and the tumour microenvironment2022
- Author(s)
  Takasugi M, Yoshida Y, Ohtani N
- Journal Title
  
  Mol Oncol
  
  Volume: 16 Issue: 18 Pages: 3333-3351
- DOI
  10.1002/1878-0261.13268
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H03369
[Journal Article] Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion2021
- Author(s)
  Okumura Shintaro、Konishi Yusuke、Narukawa Megumi、Sugiura Yuki、Yoshimoto Shin、Arai Yuriko、Sato Shintaro、Yoshida Yasuo、Tsuji Shunya、Uemura Ken、Wakita Masahiro、Matsudaira Tatsuyuki、Matsumoto Tomonori、Kawamoto Shimpei、Takahashi Akiko、Itatani Yoshiro、Miki Hiroaki ら
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 5674-5674
- DOI
  10.1038/s41467-021-25965-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-21H05272, KAKENHI-PROJECT-19H03702, KAKENHI-PROJECT-20H03515, KAKENHI-PROJECT-20K07446, KAKENHI-PROJECT-20K09930, KAKENHI-PROJECT-21K19406, KAKENHI-PROJECT-21K15974, KAKENHI-PROJECT-19H03507, KAKENHI-PROJECT-21H03369, KAKENHI-PROJECT-20K16156
[Journal Article] Gut-liver axis-mediated mechanism of liver cancer: A special focus on the role of gut microbiota.2021
- Author(s)
  Ohtani N and Hara E
- Journal Title
  
  Cancer Sci
  
  Volume: 112 Issue: 11 Pages: 4433-4443
- DOI
  10.1111/cas.15142
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03369
[Journal Article] Bioinformatics Analysis of Oral, Vaginal, and Rectal Microbial Profiles during Pregnancy: A Pilot Study on the Bacterial Co-Residence in Pregnant Women2021
- Author(s)
  Fudaba Megumi、Kamiya Tomonori、Tachibana Daisuke、Koyama Masayasu、Ohtani Naoko
- Journal Title
  
  Microorganisms
  
  Volume: 9 Issue: 5 Pages: 1027-1027
- DOI
  10.3390/microorganisms9051027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16121, KAKENHI-PROJECT-21H03369
[Journal Article] Epidermal growth factor receptor is a host entry cofactor triggering hepatitis B virus internalization2019
- Author(s)
  M. Iwamoto, W. Saso, R. Sugiyama, K. Ishii, M. Ohki, S. Nagamori, R. Suzuki, H. Aizaki, A. Ryo, J-H Yun, S-Y Park, N. Ohtani, M. Muramatsu, S. Iwami, Y. Tanaka, C. Sureau, T. Wakita and K. Watashi
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 116 Issue: 17 Pages: 8487-8492
- DOI
  10.1073/pnas.1811064116
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PUBLICLY-17H05819, KAKENHI-PROJECT-16H04845, KAKENHI-PROJECT-18H01139, KAKENHI-PROJECT-16KT0111, KAKENHI-PROJECT-15K09034, KAKENHI-PROJECT-15KT0107, KAKENHI-PROJECT-16K08825, KAKENHI-PROJECT-16K13777, KAKENHI-PROJECT-19K16672, KAKENHI-PROJECT-18H02413, KAKENHI-PROJECT-19J21455, KAKENHI-PROJECT-17H04085, KAKENHI-PROJECT-16H04699
[Journal Article] Role of the Gut-Liver Axis in Liver Inflammation, Fibrosis, and Cancer: A Special Focus on the Gut Microbiota Relationship.2019
- Author(s)
  Ohtani N, Kawada N.
- Journal Title
  
  Hepatol Commun
  
  Volume: 3 Issue: 4 Pages: 456-470
- DOI
  10.1002/hep4.1331
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03641, KAKENHI-PROJECT-16H04699
[Journal Article] The aryl hydrocarbon receptor?cytochrome P450 1A1 pathway controls lipid accumulation and enhances the permissiveness for hepatitis C virus assembly2018
- Author(s)
  Ohashi Hirofumi、Nishioka Kazane、Nakajima Syo、Kim Sulyi、Suzuki Ryosuke、Aizaki Hideki、Fukasawa Masayoshi、Kamisuki Shinji、Sugawara Fumio、Ohtani Naoko、Muramatsu Masamichi、Wakita Takaji、Watashi Koichi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 293 Issue: 51 Pages: 19559-19571
- DOI
  10.1074/jbc.ra118.005033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09447, KAKENHI-PROJECT-18K05343, KAKENHI-PROJECT-18J14277, KAKENHI-PROJECT-15K09034, KAKENHI-PROJECT-17H04085, KAKENHI-PROJECT-16H04699
[Journal Article] Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells2018
- Author(s)
  Takahashi A, Loo TM, Okada R, Kamachi F, Watanabe Y, Wakita M, Watanabe S, Kawamoto S, Miyata K, Barber GN, Ohtani N, Hara E
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 1249-1249
- DOI
  10.1038/s41467-018-03555-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19031, KAKENHI-PUBLICLY-17H05628, KAKENHI-PROJECT-16H04700, KAKENHI-PROJECT-17K19618, KAKENHI-PROJECT-18K15065, KAKENHI-PROJECT-16H04699
[Journal Article] Chemical array system, a platform to identify novel hepatitis B virus entry inhibitors targeting sodium taurocholate cotransporting polypeptide2018
- Author(s)
  Kaneko M, Futamura Y, Tsukuda S, Kondoh Y, Sekine T, Hirano H, Fukano K, Ohashi H, Saso W, Morishita R, Matsunaga S, Kawai F, Ryo A, Park S-Y, Suzuki R, Aizaki H, Ohtani N, Sureau C, Wakita T, Osada H, Watashi K
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 2769-2769
- DOI
  10.1038/s41598-018-20987-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05366, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-15K09034, KAKENHI-PROJECT-16K19145, KAKENHI-PROJECT-26460565, KAKENHI-PROJECT-17H04085, KAKENHI-PROJECT-16H04699
[Journal Article] Functional association of cellular microtubules with viral capsid assembly supports efficient hepatitis B virus replication2017
- Author(s)
  Iwamoto M、Cai D、Sugiyama M、Suzuki R、Aizaki H、Ryo A、Ohtani N、Tanaka Y、Mizokami M、Wakita T、Guo H、Watashi K
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 10620-10620
- DOI
  10.1038/s41598-017-11015-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15J03185, KAKENHI-PROJECT-26460565, KAKENHI-PROJECT-17H04085, KAKENHI-PROJECT-16H04699
[Journal Article] Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity.2017
- Author(s)
  Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo MM, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N.
- Journal Title
  
  Cancer Discov
  
  Volume: 7 Pages: 522-538
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04699
[Journal Article] Gut microbiota promotes obesity-associated liver cancer through PGE2-mediated suppression of antitumor immunity.2017
- Author(s)
  Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo M, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N.
- Journal Title
  
  Cancer Discov
  
  Volume: in press Issue: 5 Pages: 522-538
- DOI
  10.1158/2159-8290.cd-16-0932
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05898, KAKENHI-PLANNED-15H05905, KAKENHI-PROJECT-26250028, KAKENHI-PROJECT-14J06998, KAKENHI-PROJECT-15K12709, KAKENHI-PROJECT-15K19032, KAKENHI-PROJECT-26670030, KAKENHI-PROJECT-15K19031, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-17H01531, KAKENHI-PROJECT-15H04648, KAKENHI-PROJECT-17H03990, KAKENHI-PROJECT-26460565, KAKENHI-PROJECT-16H04699
[Journal Article] The impact of SASP and its potential as a therapeutic target for senescence-associated diseases.2017
- Author(s)
  Watabnabe, S., Kawamoto, S., Ohtani, N., & Hara, E.
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 4 Pages: 563-569
- DOI
  10.1111/cas.13184
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26250028, KAKENHI-PROJECT-26430116, KAKENHI-PROJECT-16H04699
[Journal Article] Dysregulation of the Bmi-1/p16Ink4a pathway provokes an aging-associated decline of submandibular gland function.2015
- Author(s)
  Yamakoshi K, Katano S, Iida M, Kimura H, Okuma A, Ikemoto-Uezumi M, Ohtani N, Hara E, Maruyama M.
- Journal Title
  
  Aging Cell
  
  Volume: - Issue: 4 Pages: 1-9
- DOI
  10.1111/acel.12337
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-14J10280, KAKENHI-PLANNED-23112101, KAKENHI-PROJECT-24650625, KAKENHI-PROJECT-26250028, KAKENHI-PROJECT-15K12709, KAKENHI-PROJECT-25861349
[Journal Article] Crosstalk between the RB-pathway and AKT signalling forms a Quiescence-Senescence switch.2014
- Author(s)
  Imai, Y., Takahashi, A., Hanyuu, A., Hori, S., Sato, S., Naka, K., Hirao, A., Ohtani, N., Hara, E.
- Journal Title
  
  Cell Reports
  
  Volume: 7 Issue: 1 Pages: 194-207
- DOI
  10.1016/j.celrep.2014.03.006
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23112101, KAKENHI-PROJECT-23300343, KAKENHI-PROJECT-23300352, KAKENHI-PROJECT-24240119, KAKENHI-PROJECT-24650625, KAKENHI-PUBLICLY-25130705, KAKENHI-PROJECT-25290046, KAKENHI-PROJECT-26250028
[Journal Article] Crosstalk between RB-pathway and AKT signaling forms a Quiescence-Senescence switch2014
- Author(s)
  Imai Y, Takahashi A, Hanyuu A, Hori S, Sato S, Naka K, Hirao A, Ohtani N, and Hara E
- Journal Title
  
  Cell Reports 10
  
  Volume: 7 Pages: 194-207
- Data Source
  KAKENHI-PROJECT-23300343
[Journal Article] Roles and mechanisms of cellular senescence in regulation of tissue homeostasis2013
- Author(s)
  Ohtani N and Hara E
- Journal Title
  
  Cancer Science
  
  Volume: 104 Pages: 525-30
- Data Source
  KAKENHI-PROJECT-23300343
[Journal Article] Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome2013
- Author(s)
  Yoshimoto S, Loo TM, Atarashi K, Kanda H, Sato S, Oyadomari S, Iwakura Y, Oshima K, Morita H, Hattori M, Honda K, Ishikawa Y, Hara E, Ohtani N
- Journal Title
  
  Nature
  
  Volume: 499 Pages: 97-101
- Data Source
  KAKENHI-PROJECT-23300343
[Journal Article] 細胞老化による発がん制御－細胞老化の功罪－2013
- Author(s)
  佐藤正大、大谷直子、原　英二
- Journal Title
  
  実験医学
  
  Volume: 31 Pages: 733-738
- Data Source
  KAKENHI-PROJECT-23300343
[Journal Article] マイクロバイオームとがん2013
- Author(s)
  大谷直子、原　英二
- Journal Title
  
  医学のあゆみ
  
  Volume: 246 Pages: 1095-1101
- Data Source
  KAKENHI-PROJECT-23300343
[Journal Article] Antitumor Impact of p14ARF on Gefitinib-Resistant Non-Small Cell Lung Cancers2013
- Author(s)
  Saito K, Takigawa N, Ohtani N, Iioka H, Tomita Y, Ueda R, Fukuoka J, Kuwahara K, Ichihara E, Kiura K, Kondo E
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 12 Pages: 1616-28
- Data Source
  KAKENHI-PROJECT-23300343
[Journal Article] Antitumor Impact of p14ARF on Gefitinib-Resistant Non-Small Cell Lung Cancers.2013
- Author(s)
  Saito K, Takigawa N, Ohtani N, Iioka H, Tomita Y, Ueda R, Fukuoka J, Kuwahara K, Ichihara E, Kiura K, Kondo E.
- Journal Title
  
  Molecule Cancer Therapeutics
  
  Volume: 12 Issue: 8 Pages: 1616-1628
- DOI
  10.1158/1535-7163.mct-12-1239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300343, KAKENHI-PROJECT-23390221, KAKENHI-PROJECT-24590388, KAKENHI-PUBLICLY-25112716, KAKENHI-PROJECT-25290062, KAKENHI-PROJECT-25670263
[Journal Article] Cellular senescence : a double-edged sword in the fight against cancer2012
- Author(s)
  Ohtani N, Takahashi A, Mann D.J., Hara E.
- Journal Title
  
  Experimental Dermatology
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22019042
[Journal Article] DNA Damage Signaling Triggers Degradation of Histo Methyltransferases through APC/C^<Cdh1> in Senescent Cells2012
- Author(s)
  Takahashi A, Imai Y, Yamakoshi K, Kuninaka S, Ohtani N, Yoshimoto S, Hori S, Tachibana M, Anderton E, Takeuchi T, Shinkai Y, Peters G, Saya H, Hara E
- Journal Title
  
  Molecular Cell
  
  Volume: Vol 45 Pages: 123-131
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22019042
[Journal Article] Cellular senescence : a double-edged sword in the fight against cancer2012
- Author(s)
  Ohtani N, Takahashi A, Mann D.J., Hara E
- Journal Title
  
  Experimental Dermatology
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300343
[Journal Article] DNA Damage Signaling Triggers Degradation of Histone Methyltransferases through APC/C^<Cdh1> in Senescent Cells2012
- Author(s)
  Takahashi A, Imai Y, Yamakoshi K, Kuninaka S, Ohtani N, Yoshimoto S, Hori S, Tachibana M, Anderton E, Takeuchi T, Shinkai Y, Peters G, Saya H, Hara E
- Journal Title
  
  Molecular Cell
  
  Volume: Vol 45 Pages: 123-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300343
[Journal Article] Cellular senescence: a double-edged sword in the fight against cancer.2012
- Author(s)
  Ohtani N, Takahashi A, Mann DJ, Hara E.
- Journal Title
  
  Experimental Dermatology
  
  Volume: 21, supplement 1 Issue: s1 Pages: 1-4
- DOI
  10.1111/j.1600-0625.2012.01493.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300343
[Journal Article] 細胞老化のがん抑制と発癌促進における役割2011
- Author(s)
  大谷直子、原英二
- Journal Title
  
  実験医学
  
  Volume: vol.29 Pages: 85-91
- Data Source
  KAKENHI-PROJECT-23300343
[Journal Article] 細胞老化のがん抑制と発癌促進における役割2011
- Author(s)
  大谷直子、原英二
- Journal Title
  
  実験医学
  
  Volume: vol.29 Pages: 85-91
- Data Source
  KAKENHI-PUBLICLY-22019042
[Journal Article] Intrinsic cooperation between p16^<Ink4a> and p21^<Waf/Cip1> in the onset of cellular senescence and tumor suppression in vivo.2010
- Author(s)
  Takeuchi S, Takahashi A, Motoi N, Yoshimoto S, Tajima T, Yamakoshi K, Hirao A, Yanagi S, Fukami K, Ishikawa Y, Sone S., Hara E., Ohtani N.
- Journal Title
  
  Cancer Research
  
  Volume: 70 Pages: 9381-9390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300229
[Journal Article] Real-time in vivo imaging of p16^<Ink4a> gene expression : a new approach to st〓senescence stress signaling in living animals2010
- Author(s)
  Ohtani N, Yamakoshi K, Takahashi A, Hara E.
- Journal Title
  
  Cell Division 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20058027
[Journal Article] Real-time in vivo imaging of p16^<Ink4a> gene expression : a new approach to study senescence stress signaling in living animals.2010
- Author(s)
  Ohtani N, Yamakoshi K, Takahashi A, Hara E
- Journal Title
  
  Cell Division 5:1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300229
[Journal Article] Intrinsic cooperation between p16^<Ink4a> and p21^<Waf/Cip1> in the onset of cellular senescence and tumor suppression in vivo.2010
- Author(s)
  Takeuchi S, Takahashi A, Motoi N, Yoshimoto S, Tajima T, Yamakoshi K, Hirao A, Yanagi S, Fukami K, Ishikawa Y, Sone S., Hara E., Ohtani N
- Journal Title
  
  Cancer Research 70
  
  Pages: 9381-9390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300229
[Journal Article] Intrinsic cooperation between p16^<Ink4a> and p21^<Waf/Cip1> in the onset of cellular senescence and tumor suppression in vivo.2010
- Author(s)
  Takeuchi S, Takahashi A, Motoi N, Yoshimoto S, Tajima T, Yamakoshi K, Hirao A, Yanagi S, Fukami K, Ishikawa Y, Sone S., Hara E., Ohtani N.
- Journal Title
  
  Cancer Research
  
  Volume: 70 Pages: 9381-9390
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22019042
[Journal Article] Real-time in vivo imaging of p16^<Ink4a> gene expression : a new approach to study senescence stress signaling in living animals2010
- Author(s)
  Ohtani N, Yamakoshi K, Takahashi A, Hara E.
- Journal Title
  
  Cell Division 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300229
[Journal Article] Cellular senescence : Its role in tumor suppression and aging.2009
- Author(s)
  Ohtani N, Mann D. J., Hara E.
- Journal Title
  
  Cancer Science 100
  
  Pages: 792-797
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300229
[Journal Article] Real-time in vivo imaging of p16^<Ink4a> reveals cross talk with p53.2009
- Author(s)
  Yamakoshi K, Takahashi A, Hirota F, Nakayama R, Ishimaru N, Kubo Y, J. Mann D. J, Ohmura M., Hirao A, Saya H, Arase S, Hayashi Y, Nakao K., Matsumoto M, Ohtani N, Hara E
- Journal Title
  
  J.Cell Biol. 186
  
  Pages: 393-407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300229
[Journal Article] Real-time in vivo imaging of p16^<Ink4a> reveals cross talk with p532009
- Author(s)
  Yamakoshi K, Takahashi A, Hirota F, Nakayama R, Ishimaru N, Kubo Y, J.Mann D.J, Ohmura M, Hirao A, Saya H, Arase S, Hayashi Y, Nakao K, Matsumoto M, Ohtani N, Hara E
- Journal Title
  
  Journal of Cell Biology 186
  
  Pages: 393-407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20058027
[Journal Article] Real-time in vivo imaging of p16^<Ink4a> reveals cross talk with p532009
- Author(s)
  Yamakoshi K, Takahashi A, Hirota F, Nakayama R, Ishimaru N, Kubo Y, J.Mann D.J, Ohmura M, Hirao A, Saya H, Arase S, Hayashi Y, Nakao K, Matsumoto M, Ohtani N, Hara E
- Journal Title
  
  Journal of Cell Biology 186
  
  Pages: 393-407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300229
[Journal Article] Cellular senescence: Its role in tumor suppression and aging.2009
- Author(s)
  Naoko Ohtani, David J. Mann, and Eiji Hara
- Journal Title
  
  Cancer Science 100
  
  Pages: 792-797
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20058027
[Journal Article] Cellular senescence : Its role in tumor suppression and aging2009
- Author(s)
  Naoko Ohtani, et al.
- Journal Title
  
  Cancer Science 100
  
  Pages: 792-797
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300229
[Journal Article] CDKインヒビターp21^<Waf1/Cip1>遺伝子発現ダイナミクスの生体内イメージング生命現象の動的理解を目指すライブイメージング2008
- Author(s)
  大谷直子、原英二
- Journal Title
  
  実験医学増刊号 vol.26,No.17
  
  Pages: 50-58
- Data Source
  KAKENHI-PROJECT-20300229
[Journal Article] 生体内におけるp21遺伝子発現のリアルタイム・イメージング2008
- Author(s)
  大谷直子、原英二
- Journal Title
  
  細胞工学 vol27,No.2
  
  Pages: 170-171
- Data Source
  KAKENHI-PROJECT-20300229
[Journal Article] Epigenetic abnormalities in cutaneous squamous cell carcinomas : Frequent inactivation of the RBI/p16 and p53 pathways.2006
- Author(s)
  Murao, K., Kubo, Y., Ohtani, N., Hara, E., Arase S
- Journal Title
  
  British Journal of Dermatology 155
  
  Pages: 999-1005
- Data Source
  KAKENHI-PROJECT-16390318
[Journal Article] and Arase S Epigenetic abnormalities in cutaneous squamous cell carcinomas : Frequent inactivation of the RB1/p16 and p53 pathways.2006
- Author(s)
  Murao, K., Kubo, Y., Ohtani, N., Hara, E.
- Journal Title
  
  British Journal of Dermatology 155
  
  Pages: 999-1005
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390318
[Journal Article] Mitogenic signalling and the p16INK4a/Rb pathway co-operate to enforce irreversible cellular senescence2006
- Author(s)
  Takahashi, A., Ohtani, N., Yamakoshi, K., Iida, S., Tahara, H., Nakayama, K., Nakayama, K.I., Ide, T., Saya, H., Hara, E.
- Journal Title
  
  Nature Cell Biology 8
  
  Pages: 1291-1297
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390318
[Journal Article] Mitogenic signalling and the p16INK4a/Rb pathway co-operate to enforce irreversible cellular senescence.2006
- Author(s)
  Takahashi, A., Ohtani, N., Yamakoshi, K., Iida, S., Tahara, H., Nakayama, K., Nakayama, K.I., Ide, T., Saya, H., Hara, E.
- Journal Title
  
  Nature Cell Biology 8
  
  Pages: 1291-1297
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390318
[Journal Article] Mitogenic signalling and the p16INK4a/Rb pathway co-operate to enforce irreversible cellular senescence.2006
- Author(s)
  Takahashi, A., Ohtani, N., Yamakoshi, K., Iida, S., Tahara, H., Nakayama, K., Nakayama, K.I., Ide, T., H., Saya, H., Hara, E.
- Journal Title
  
  Nature Cell Biology 8
  
  Pages: 1291-1297
- Data Source
  KAKENHI-PROJECT-16390318
[Journal Article] Epigenetic abnormalities in cutaneous squamous cell carcinomas : Frequent inactivation of the RB1/p16 and p53 pathways.2006
- Author(s)
  Murao, K., Kubo, Y., Ohtani, N., Hara, E., Arase S
- Journal Title
  
  British Journal of Dermatology 155
  
  Pages: 999-1005
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390318
[Journal Article] Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p53.2005
- Author(s)
  Maehara K, Yamakoshi K, Ohtani N, Kubo Y, Takahashi A, Arase S, Jones N, Hara E
- Journal Title
  
  Journal of Cell Biology 168
  
  Pages: 552-560
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390318
[Presentation] Inter-Cellular Network Analysis in Tumor Microenvironment During The Progression of MASLD/MASH-HCC.2024
- Author(s)
  59.Yoshiki Nonaka, Atsuki Uno, Kanae Echizen, Yuya Yoshida, Fumiya Sobue, Takahiro Kodama, Naoko Ohtani.
- Organizer
  APASL Kyoto
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] The role and mechanism of SASP in the tumor microenvironment of steatosis-associated liver cancer.2024
- Author(s)
  Naoko Ohtani
- Organizer
  A3 Foresight Program Kick-off meeting　Cellular Senescence: from Pathophysiology to Treatment
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] Tumor promoting interatome/network analysis during the progression of MASLD/MASH-associated liver cancer model.2024
- Author(s)
  Yoshiki Nonaka, Atsuki Uno, Kanae Echizen, Yuya Yoshida, Fumiya Sobue, Takahiro Kodama, Naoko Ohtani.
- Organizer
  The 1st International Symposium on Cancer Immunology and Immunotherapy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] The role of senescence-associated secretory phenotype (SASP) in modulating anti-tumor immunity in steatosis-associated liver cancer.2024
- Author(s)
  Naoko Ohtani
- Organizer
  The 1st International Symposium on Cancer Immunology and Immunotherapy
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 肥満と肝がん～Leaky gut による腸内細菌関連物質の肝移行とがん微小環境形成～2024
- Author(s)
  大谷直子
- Organizer
  49回日本微小循環学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] Low-speed regular exercise reduces HCC development by muscle PGC1α-mediated kynurenine degradation.2024
- Author(s)
  Naoko Ohtani, Vu Thuong Huyen, Ryota Yamagishi, Kanae Echizen, Yoshiki Nonaka, Shinji Fukuda
- Organizer
  APASL Kyoto
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] がん微小環境と腸内細菌2024
- Author(s)
  大谷直子
- Organizer
  第38回札幌冬季がんセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] Identification of tumor-promoting secreted factors in the progression of steatosis-associated HCC.2024
- Author(s)
  60.Atsuki Uno, Yoshiki Nonaka, Kanae Echizen, Ryota Yamagishi, Takahiro Kodama, and Naoko Ohtani
- Organizer
  APASL Kyoto
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] Leaky gut による腸内細菌関連物質の肝移行と肝がん微小環境形成2024
- Author(s)
  大谷直子
- Organizer
  第19回日本がん分子標的治療学会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 研究と子育てを両立させる作戦　インフォマティクス解析を取り入れた研究スタイル2023
- Author(s)
  越前佳奈恵　大谷直子
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] Gut-liver Axis-Mediated Mechanism of Obesity-Associated Hepatocellular Carcinoma Progression.2023
- Author(s)
  Naoko Ohtani
- Organizer
  The 2nd JCA-AACR Precision Cancer Medicine International Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] IL-33によるNASH関連肝がん促進機構の解明2023
- Author(s)
  山岸良多、大谷直子
- Organizer
  第27回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 肥満誘導性肝がん微小環境におけるがん進展過程を考慮したネットワーク解析(Tumor-promoting interactome/network analysis during the progression of NAFLD/NASH-associated liver cancer model)2023
- Author(s)
  野中允幾, 宇野敦葵, 越前佳奈恵, 山岸良多, 大谷直子
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 腸内細菌叢と肥満関連肝がん～腸内細菌関連物質の肝移行によるがん微小環境形成～2023
- Author(s)
  大谷直子
- Organizer
  千里ライフサイエンスセミナーⅤ３　第９回がんシリーズ
- Invited
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 腸内細菌叢とがん免疫療法2023
- Author(s)
  大谷直子
- Organizer
  第46回近畿小児血液・がん研究会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 腸内細菌叢と肝がん2023
- Author(s)
  大谷直子
- Organizer
  日本乳酸菌学会 2023 年度大会　BMFH セミナー
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 肥満誘導性肝臓がん微小環境における様々ながん促進的経路に着目した機能的インタラクトーム解析(Functional interactome analysis in various tumor-promoting pathways in obesity-associated liver tumor microenvironment)2023
- Author(s)
  大谷直子
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 肝がん微小環境におけるガスダーミンDによるSASP因子の放出とがん進展機構2023
- Author(s)
  大谷直子
- Organizer
  第46回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 規則的な運動はオンコメタボライトKynurenineを減少させることで肥満誘導性肝がんの進展を抑制する2023
- Author(s)
  ヴトゥンフェン、山岸良多、大谷直子
- Organizer
  第27回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 細胞老化とＳＡＳＰ：その誘導機構とがん微小環境における役割2023
- Author(s)
  大谷直子
- Organizer
  第96回日本内分泌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 肝がん微小環境における細胞老化・SASPの役割とその制御～SASP因子放出のメカニズム～2023
- Author(s)
  大谷直子
- Organizer
  第31回日本Cell Death学会
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 非アルコール性脂肪肝疾患関連肝がんにおける細胞傷害性T細胞の肝臓への遊走メカニズムと治療への応用2023
- Author(s)
  神谷知憲, 藤井英樹, 武藤芳美, 河田則文, 大谷直子
- Organizer
  第27回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 腸内細菌が関わる肝発癌と免疫応答(Commensal bacteria and tumor immunity　Hepatic Carcinogenesis and Immune Response Involving Gut microbial metabolites)2023
- Author(s)
  山岸良多, 蒲池史卓, 程イ, 河田則文, 原英二, 大谷直子
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] がん微小環境における細胞老化・SASPの役割とその制御2023
- Author(s)
  大谷直子
- Organizer
  第23回抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 運動による代謝変化を介したNASH関連肝がん抑制機構2023
- Author(s)
  山岸良多, VU Thuong Huyen, 野中允幾, 越前佳奈恵, 矢野めぐむ, 神谷知憲, 大谷直子
- Organizer
  第44回日本臨床栄養協会総会第21回大連合大会
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 腸内細菌叢と肝がん2023
- Author(s)
  大谷直子
- Organizer
  第31回日本医学会総会
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 肝疾患の病態に基づいた治療戦略　細胞老化・SASPのがん微小環境における役割とそれを標的とするセノセラピー2023
- Author(s)
  大谷直子
- Organizer
  第31回日本消化器関連学会週間（JDDW）
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 規則的な運動による代謝変化とがん抑制2023
- Author(s)
  大谷直子
- Organizer
  第9回がんと代謝研究会 in 松山
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] Gut-liver axis-mediated mechanism of NASH(MASH)-associated hepatocellular carcinoma progression.2023
- Author(s)
  Naoko Ohtani
- Organizer
  The 3rd JSH International Liver Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 肝がん微小環境におけるSASP因子放出の分子メカニズムと肝がんの進展機構の解明(Molecular mechanism of SASP factor release in liver tumor microenvironment and hepatocellular carcinoma progression)2023
- Author(s)
  山岸良多, 蒲池史卓, 河田則文, 原英二, 大谷直子
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 肝性脳症における腸内細菌叢ーリファキリミン非著効例における菌種の機能解析ー2022
- Author(s)
  武藤芳美，河田則文，大谷直子
- Organizer
  第108回日本消化器病学会総会ワークショップ1
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] Hepatic transfer of gut microbial component promotes obesity-associated liver cancer progression2022
- Author(s)
  Naoko Ohtani
- Organizer
  日本学術振興会主催の第23回北東アジアシンポジウム（テーマ：細胞老化）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] ガレクチン３による骨格筋内異所性脂肪の形成促進; ～シングルセル解析を利用した分化異常の検出～2022
- Author(s)
  大谷直子
- Organizer
  第8回日本筋学会学術集会シンポジウム7：健康長寿の実現に向けたサルコペニア／フレイル研究の新展開
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] Non-heat-stressed method to isolate hepatic stellate cells from highly steatotic tumor-bearing liver usingCD49a2022
- Author(s)
  Yi Cheng, Ryota Yamagishi, Yoshiki Nonaka, Misako Sato-Matsubara, Norifumi Kawada, and Naoko Ohtani
- Organizer
  THE LIVER SINUSOID MEETING,21st ISCHS Meeting
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] IL-33によるNASH関連肝がん促進機構2022
- Author(s)
  山岸良多、武藤芳美、河田則文、大谷直子
- Organizer
  第59回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] IL-33released from senescent hepatic stellate cell promotes obesity-associated hepatocellular carcinoma2022
- Author(s)
  Ryota Yamagishi, Fumitaka Kamachi, Tomonori Kamiya, Yi Cheng, Yoshiki Nonaka, Norifumi Kawada, Susumu Nakae, Eiji Hara, Naoko Ohtani
- Organizer
  APASL Oncology 2022 Single Topic conference in Takamatsu
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] The role of hepatic stellate cells in tumor microenvironment of obesity-associated liver cancer2022
- Author(s)
  Naoko Ohtani
- Organizer
  The 2nd Osaka Metropolitan University International Liver Forum
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] Obesity-associated liver cancer: the role of hepatic translocation of gut microbial factors2022
- Author(s)
  Naoko Ohtani
- Organizer
  IHMC KOBE 2022 The International Human Microbiome Consortium Congress
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] Intestinal microbiome and liver cancer2022
- Author(s)
  Naoko Ohtani
- Organizer
  USJCMSP 2023 International Conference on Emerging Infectious Diseases Cancer Panel
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] IL-33released from senescent hepatic stellate cell promotes obesity-associated hepatocellular carcinoma2022
- Author(s)
  Ryota Yamagishi, Fumitaka Kamachi, Yi Cheng, Norifumi Kawada, Eiji Hara, Naoko Ohtani
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 腸内細菌叢と肥満関連肝がん; ～Leaky gutによる腸内細菌関連物質の肝移行の関与～2022
- Author(s)
  大谷直子
- Organizer
  第26回腸内細菌学会学術集会　シンポジウム2：マイクロバイオームの制御と健康
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] The role and mechanism of SASP in tumor microenvironment of obesity-associated liver cancer2022
- Author(s)
  Naoko Ohtani
- Organizer
  The 12th AACR-JCA Joint Conference: Breakthroughs in Cancer Research: Translating Knowledge into Practice
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] Rifaximin治療効果に基づく肝性脳症原因菌の同定とメカニズムの解明2022
- Author(s)
  武藤（湯川）芳美，河田則文，大谷直子
- Organizer
  日本消化器関連学会週間（JDDW）ワークショップ「消化器疾患とマイクロバイオーム研究の新展開」
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 肥満による肝がんの進展メカニズム　～腸内細菌関連因子の関与～2022
- Author(s)
  大谷直子
- Organizer
  第2回バイオインダストリー協会　機能性食品研究会講演会
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 加齢にともなう遺伝子発現変化は長寿の指標として有益なものである：比較生物学的アプローチより2022
- Author(s)
  吉田優矢、高杉征樹、野中允幾、大谷直子
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 肝性脳症発症に関わる腸内細菌の探索2022
- Author(s)
  武藤芳美、神谷知憲、小田桐直志、小谷晃平、元山宏行、川村悦史、萩原淳司、藤井英樹、打田佐和子、榎本大、河田則文、大谷直子
- Organizer
  第29回日本門脈圧亢進症学会総会パネルディスカッション3
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] Regular exercise suppresses obesity associated liver cancer through activating Pgc-1α-Kynurenine degrading pathway2022
- Author(s)
  Vu Thuong Huyen, Ryota Yamagishi, Naoko Ohtani
- Organizer
  APASL Oncology 2022 Single Topic conference in Takamatsu
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 肝性脳症発症に関わる腸内細菌の同定2022
- Author(s)
  神谷知憲，武藤芳美，藤井英樹，森宙史，豊田敦，福田真嗣，河田則文，大谷直子
- Organizer
  第26回腸内細菌学会学術集会
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] Combined Bioinformatics on the Tumor Promoting Inter-cellular Network in Obesity-associated Liver Tumor Microenvironment2022
- Author(s)
  Yoshiki Nonaka, Ryota Yamagishi, Yi Cheng, Naoko Ohtani
- Organizer
  APASL Oncology 2022 Single Topic conference in Takamatsu
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] Hepatic transfer of gut microbial component promotes obesity-associated liver cancer progression2022
- Author(s)
  Naoko Ohtani
- Organizer
  第81回日本癌学会学術総会Symposium 5 Metabolic alteration in the Tumor microenvironment
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] がん微小環境における細胞老化とSASPの役割：ガスダーミンDを介するSASP因子の放出が肥満関連肝がんを促進させる2022
- Author(s)
  山岸良多、蒲池史卓、神谷知憲、高杉征樹、程禕、野中允幾、河田則文、中江進、原英二、大谷直子
- Organizer
  日本生理学会第100回記念大会
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 肥満と肝がん　～腸内細菌関連物質の肝移行とがん微小環境形成～2022
- Author(s)
  大谷直子
- Organizer
  第35回日本バイオセラピィ学会学術集会総会モーニングセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 細胞老化とＳＡＳＰ：その誘導機構とがん微小環境における役割2022
- Author(s)
  大谷直子
- Organizer
  第48回日本臓器保存生物医学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 肥満誘導性肝がん微小環境における腫瘍促進ネットワークの複合解析2022
- Author(s)
  野中允幾、山岸良多、程禕、小玉尚宏、大谷直子
- Organizer
  NGS EXPO 2022
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] Gut-liver Axis-Mediated Mechanism of Obesity-Associated Hepatocellular Carcinoma Progression2022
- Author(s)
  Naoko Ohtani
- Organizer
  Asian Pacific Association for the Study of the Liver (APASL) 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] Identification and characterization of the gut microbial species responsible for hyperammonemia in hepatic encephalopathy from the analysis of patients administered rifaximin2022
- Author(s)
  Yoshimi Yukawa-Muto, Tomonori Kamiya, Norifumi Kawada, Naoko Ohtani
- Organizer
  IHMC KOBE 2022～The International Human Microbiome Consortium Congress～
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 肥満と肝がん;腸内細菌叢成分による肝がん促進的微小環境の形成2022
- Author(s)
  大谷直子
- Organizer
  第8回がんと代謝研究会 in 佐渡
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 比較生物学的アプローチから示される加齢にともなう遺伝子発現変化とその生体における有益性2022
- Author(s)
  吉田優矢、高杉征樹、野中允幾、大谷直子
- Organizer
  NGS EXPO 2022
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 腸内細菌叢と肥満関連肝がん～Leaky gutによる腸内細菌関連物質の肝移行の関与～2022
- Author(s)
  大谷直子
- Organizer
  第54回無菌生物ノートバイオロジー学会　シンポジウム　「常在細菌と宿主免疫の新たな展開」
- Invited
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 肥満誘導性肝がん微小環境における腫瘍促進ネットワークの複合バイオインフォマティクス解析2022
- Author(s)
  野中允幾、山岸良多、程禕、大谷直子
- Organizer
  第81回日本癌学会学術総会(横浜）
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] Regular exercise suppresses obesity associated liver cancer through activating Pgc-1α-Kynurenine degrading pathway2022
- Author(s)
  Vu Thuong Huyen, Ryota Yamagishi, Naoko Ohtani
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] Gut-liver axis-mediated mechanism of SASP in tumor microenvironment of obesity-associated liver cancer2021
- Author(s)
  Naoko Ohtani
- Organizer
  Keystone Symposia, “Cancer: Aging on the Drivber’s seat”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] The role of gut microbiota in obesity-associated liver cancer development2021
- Author(s)
  Naoko Ohtani
- Organizer
  The 50th Annual Meeting of the Japanese Society for Immunology（日本免疫学会学術集会）, Symposium SY-1 Systemic organ interactions in health and disease
- Invited
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 腸内細菌叢と肝疾患～肝性脳症～2021
- Author(s)
  大谷直子
- Organizer
  第４８回日本毒性学会学術年会　シンポジウム　マイクロバイオームの最先端
- Invited
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] Gut-liver axis-mediated mechanism of NASH-associated hepatocellular carcinoma progression2021
- Author(s)
  Ryota Yamagishi, Fumitaka Kamachi, Tomonori Kamiya, Yoshiki Nonaka, Yoshimi Muto-Yukawa, Norifumi Kawada, Susumu Nakae, Eiji Hara and Naoko Ohtani.
- Organizer
  The Asian Pacific Association for the Study of the Liver (APASL)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] Gut microbial metabolites and liver cancer2021
- Author(s)
  Naoko Ohtani
- Organizer
  The European Association for the Study of the Liver (EASL), International Liver Congress “Metabolism and cancer” Online
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] The Role of Gut Microbiota in Obesity-associated Liver Cancer development.2021
- Author(s)
  Naoko Ohtani, Fumitaka Kamachi, Tomonori Kamiya and Ryota Yamagishi.
- Organizer
  The 80th Annual meeting of JCA（日本癌学会学術総会）, Symposium 12　Metabolism in Cancer.
- Invited
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 細胞老化とSASP：その誘導機構と生体における役割2021
- Author(s)
  大谷直子
- Organizer
  第53回日本動脈硬化学術集会・総会　シンポジウム３：老化と代謝
- Invited
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 肥満と肝がん　～腸内細菌関連物質の肝移行とがん微小環境形成～2021
- Author(s)
  大谷直子
- Organizer
  第42回日本肥満学会・第39回日本肥満症治療学会学術集会シンポジウム6：肥満とがん ―分子メカニズムから疫学まで
- Invited
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 腸内細菌叢と肝がん2021
- Author(s)
  大谷直子
- Organizer
  第21回日本抗加齢医学会総会　シンポジウム11
- Invited
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 腸肝軸を介した腸内細菌成分による肝がん促進的微小環境の形成2021
- Author(s)
  大谷直子
- Organizer
  第25回日本がん免疫学会総会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] 複合オミックス解析によるサルコペニア肥満における骨格筋内異所性脂肪形成の起源及び誘因の解明2021
- Author(s)
  高田尚輝、高杉征樹、野中允幾、神谷知憲、武村和明、佐藤淳子、伊藤慎二、中村博亮、上住聡芳、大谷直子
- Organizer
  第36回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] The role and mechanism of SASP in tumor microenvironment of obesity-associated liver cancer.2021
- Author(s)
  Naoko Ohtani
- Organizer
  The 6th International Cell Senescence Assciation (ICSA) Confetence,
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03369
[Presentation] Obesity-induced gut microbiome and liver cancer ~ The suppression mechanism of anti-tumor immunity ~2019
- Author(s)
  Naoko Ohtani
- Organizer
  U.S.-Japan Cooperative Medical Sciences Program Cancer Panel Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] Regular exercise suppresses obesity-associated HCC development2019
- Author(s)
  Naoki Takada, Miho Kumagai, Tatsuya Ando, Fumitaka Kamachi, and Naoko Ohtani
- Organizer
  the 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] Obesity-induced gut microbiome and liver cancer2019
- Author(s)
  Naoko Ohtani
- Organizer
  21st International Conference on Emerging Infectious Diseases in the Pacific Rim
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] 肥満関連腸内細菌による肝がんの進展機構～がん微小環境の変化に着目して～2018
- Author(s)
  大谷直子
- Organizer
  千葉大学リーディング研究育成プログラム第3回免疫希少・難治性疾患に対する革新的治療創生研究シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] The role of gut microbial metabolites in obesity-associated liver cancer development via gut liver axis2018
- Author(s)
  Naoko Ohtani, Tze Mun Loo, Fumitaka Kamachi
- Organizer
  第４１回　日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] 腸内細菌を指標とした大腸癌診断キットの開発研究2018
- Author(s)
  奥村慎太郎, 長山聡, 大谷直子, 坂井義治, 原英二
- Organizer
  第77回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] The Role of SASP and Anti-tumor Immunity in Tumor-microenvironment of Obesity-associated liver cancer2018
- Author(s)
  Naoko Ohtani
- Organizer
  Australia Japan Medical Research Symposium September 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] Toll-like Receptor及びDNAセンサーを介した肥満誘導性肝癌の発症2018
- Author(s)
  羅智文, 岡田遼, 原英二, 大谷直子, 高橋暁子
- Organizer
  第77回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] 門亢症の包括的マネジメント当院におけるリファキシミンの初期使用成績　腸内細菌叢の変化を踏まえて2018
- Author(s)
  湯川芳美, 大谷直子, 河田則文
- Organizer
  日本門脈圧亢進症学会
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] The role and the mechanism of SASP in tumor micro-environment of obesity-associated liver cancer2018
- Author(s)
  Naoko Ohtani
- Organizer
  The 37th Sapporo International Cancer Symposium -Deciphering the complexity of cancer microenvironment-
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] The Role of SASP and Anti-tumor Immunity in Tumor-microenvironment of Obesity-associated liver cancer2018
- Author(s)
  Naoko Ohtani
- Organizer
  The 45th Naito Conference Immunological and Molecular Bases for Cancer Immunotherapy
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] Gut-Liver axis～腸内細菌代謝物による肝癌の進展機構～2017
- Author(s)
  大谷直子
- Organizer
  第２７回日本病態生理学会大会　シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] Obesity-associated gut microbiota and cancer development2017
- Author(s)
  Naoko Ohtani, Tze Mun Loo, Fumitaka Kamachi
- Organizer
  The 76th Annual meeting of JCA 　Symposium 8
- Invited
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] がん微小環境の細胞老化随伴分泌現象による肥満誘導性肝がんの促進機構2017
- Author(s)
  大谷直子
- Organizer
  第38回日本炎症・再生医学会シンポジウム３　炎症と老化
- Invited
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] Gut Microbiota Promotes Obesity-associated Liver Cancer through PGE2 mediated Suppression of Antitumor Immunity2017
- Author(s)
  Naoko Ohtani
- Organizer
  International Symposium on Imaging Frontier (ISIF2017)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] 腸内細菌由来リガンドとTLRシグナルによるPGE2の生成と肝癌の進展2017
- Author(s)
  大谷直子
- Organizer
  第11回メタボロームシンポジウムセッション　医薬分野
- Invited
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] The Role of SASP in Tumor Microenvironment of Obesity-associated Liver Cancer2017
- Author(s)
  Naoko Ohtani
- Organizer
  The 48th International Symposium of The Princess Takamatsu Cancer Research Fund
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] 腸内細菌叢が肥満誘導性肝癌の進展を促進する：デオキシコール酸(DCA)とリポタイコ酸(LTA)の協調作用2017
- Author(s)
  羅智文、蒲池史卓、渡辺喜洋、神田　浩明、大島　正伸、岩間　厚志、有田誠、原英二、大谷直子
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] IL-33 from senescent HSCs promotes obesity-associated liver cancer development by suppression of anti-tumor immunity2017
- Author(s)
  Fumitaka Kamachi, Masaru Nakamura, Shota Ymazaki, Susumu Nakae, Eiji Hara & Naoko Ohtani
- Organizer
  19th International Symposium on Cells of the Hepatic Sinusoid (ISCHS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] 腸内細菌によるリノール酸代謝産物の免疫系への作用2017
- Author(s)
  新井達也、蒲池史卓、有田誠、岸野重信、小川順、大谷直子
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] 腸内細菌代謝産物が形成する肝癌微小環境におけるinterleukin-33の役割解明2017
- Author(s)
  蒲池史卓、中村大、山﨑翔太、中島将博、羅智文、吉本真、新井達也、原田陽介、久保允人、田口速男、中江進、原英二、大谷直子
- Organizer
  第1回消化器臓器間ネットワーク研究会
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] IL-33/ST2 pathway promotes obesity-associated liver cancer development2017
- Author(s)
  Fumitaka Kamachi, Masaru Nakamura, Shota Yamazaki, Tze Mun Loo, Shin Yoshimoto, Tatsuya Arai, Yohsuke Harada, Masato Kubo, Susumu Nakae, Eiji Hara, Naoko Ohtani
- Organizer
  The 19h Takeda Science Foundation Symposium on Biosciences
- Place of Presentation
  Suita, Osaka, Japan
- Year and Date
  2017-01-20
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] SASP因子の相乗効果による肥満誘導性肝がん形成促進機構の解明2017
- Author(s)
  山崎翔太、蒲池史卓、中村大、中島将博、Loo Mun、吉本真、新井達也、田口速男、中江進、原英二、大谷直子
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] Effects of gut microbial metabolites of linoleic acid on cytokine production by immune cells2017
- Author(s)
  Fumitaka Kamachi, Tatsuya Arai, Makoto, Arita, Naoko Ohtani
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] 細胞老化・ＳＡＳＰ：その誘導機構と生体における役割2017
- Author(s)
  大谷直子
- Organizer
  第４４回日本毒性学会学術年会　シンポジウム７ストレスバイオロジーから分子毒性学への展開
- Invited
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] 肝臓オルガノイドを用いた肥満誘導性肝臓がん発症モデルの構築及び、がんの起源細胞の解明2017
- Author(s)
  窪田達寛、安藤達也、福井優也、渡辺喜洋、小澤崇之、蒲池史卓、八尾良司、佐藤俊朗、大谷直子
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] 細胞老化の生体における役割～腸内細菌代謝物による肝星細胞の老化～2017
- Author(s)
  大谷直子
- Organizer
  脳血管抗加齢研究会　特別講演２
- Invited
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] Gut Microbiota Promotes Obesity-associated Liver Cancer through PGE2 mediated Suppression of Antitumor Immunity2017
- Author(s)
  Naoko Ohtani
- Organizer
  KEYSTONE SYMPOSIA Aging and Mechanism of Aging-related Disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] Gut Microbiota Promotes Obesity-associated Liver Cancer Development: a collaborative role of lipoteichoic acid and deoxycholic acid2017
- Author(s)
  Naoko Ohtani
- Organizer
  The 4th JSGE International Topic Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] 腸肝軸と肝がん～腸内細菌代謝物デオキシコール酸による肝がんの進展機構～2017
- Author(s)
  大谷直子
- Organizer
  第３９回胆汁酸研究会シンポジウム　胆汁酸代謝と腸内細菌
- Invited
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] TLRシグナルによる脂質代謝物の生成と肝がんの促進2017
- Author(s)
  大谷直子
- Organizer
  第５回がんと代謝研究会 in 札幌セッション４　腸内細菌と代謝
- Invited
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] Synergism of SASP factors: activation mechanism of interleukin-33 in senescent hepatic stellate cells in promoting obesity-associated liver cancer2017
- Author(s)
  Shota Yamazaki, Fumitaka Kamachi, Masaru Nakamura, Masahiro Nakajima, Tze Mun Loo, Shin Yoshimoto, Tatsuya Arai, Hayao Taguchi, Susumu Nakae, Eiji Hara, Naoko Ohtani
- Organizer
  The 19h Takeda Science Foundation Symposium on Biosciences
- Place of Presentation
  Suita, Osaka, Japan
- Year and Date
  2017-01-20
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] 肥満により増加する腸内細菌による肝がん進展メカニズム2016
- Author(s)
  大谷直子
- Organizer
  第16回抗加齢医学会総会シンポジウム腸内フローラの臨床への展開
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-06-12
- Invited
- Data Source
  KAKENHI-PROJECT-15K12709
[Presentation] The Mechanism of Obesity-associated Liver Carcinogenesis: a co-operation between gut microbial metabolites and lipid.2016
- Author(s)
  Naoko Ohtani
- Organizer
  EASL, European association for the study of the liver, The International Liver Congress 2016
- Place of Presentation
  Fira Barcelona Gran Via (Barcelona, Spain)
- Year and Date
  2016-04-14
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] p16INK4aによる個体老化の新たなメカニズム2016
- Author(s)
  大谷直子
- Organizer
  第89回日本生化学会大会　シンポジウム加齢にともなう幹細胞変化と疾患の分子基盤
- Place of Presentation
  仙台国際センター（宮城県・仙台市）
- Year and Date
  2016-09-27
- Invited
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] 細胞老化・SASPとその生体における役割2016
- Author(s)
  大谷直子
- Organizer
  日本放射線影響学会　第59回大会　シンポジウム低線量放射線生物影響の課題への分子生物学的アプローチ
- Place of Presentation
  ＪＭＳアステールプラザ（広島県・広島市）
- Year and Date
  2016-10-28
- Invited
- Data Source
  KAKENHI-PROJECT-15K12709
[Presentation] Cooperative role of gut microbial components and metabolites in obesity-associated liver cancer development.2016
- Author(s)
  Tze Mun Loo and Naoko Ohtani
- Organizer
  The 75th Annual Meeting of the Japanese Cancer Association Symposium 10（日本癌学会）, Therapeutic vulnerability in infection/inflammation-associated cancer
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-10-07
- Invited
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] p16INK4aによる個体老化の新たなメカニズム2016
- Author(s)
  大谷直子
- Organizer
  第89回日本生化学会大会　シンポジウム加齢にともなう幹細胞変化と疾患の分子基盤
- Place of Presentation
  仙台国際センター（宮城県・仙台市）
- Year and Date
  2016-09-27
- Invited
- Data Source
  KAKENHI-PROJECT-15K12709
[Presentation] 細胞老化・SASPとその生体における役割2016
- Author(s)
  大谷直子
- Organizer
  日本放射線影響学会　第59回大会　シンポジウム低線量放射線生物影響の課題への分子生物学的アプローチ
- Place of Presentation
  ＪＭＳアステールプラザ（広島県広島市）
- Year and Date
  2016-10-28
- Invited
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] The role of gut microbiota for obesity-induced liver cancer development.2016
- Author(s)
  Naoko Ohtani
- Organizer
  RIKEN IMS-JSI International Symposium on Immunology 2016, Immune homeostasis and diseases.
- Place of Presentation
  Pasifico Yokohama(Yokohama, Kanagawa Japan)
- Year and Date
  2016-06-16
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12709
[Presentation] The role of gut microbiota for obesity-induced liver cancer development.2016
- Author(s)
  Naoko Ohtani
- Organizer
  RIKEN IMS-JSI International Symposium on Immunology 2016, Immune homeostasis and diseases.
- Place of Presentation
  Pacifico Yokohama(Yokohama, Kanagawa Japan)
- Year and Date
  2016-06-16
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] 肥満誘導性の腸内細菌代謝物による肝星細胞の細胞老化・ＳＡＳＰと肝がんの促進2016
- Author(s)
  羅　智文、蒲池史卓、渡辺喜洋、大谷直子
- Organizer
  第39回日本分子生物学会年会　シンポジウム臓器老化による臓器間ネットワークの破綻を探る
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-12-02
- Invited
- Data Source
  KAKENHI-PROJECT-15K12709
[Presentation] 肥満により増加する腸内細菌による肝がん進展メカニズム2016
- Author(s)
  大谷直子
- Organizer
  第16回抗加齢医学会総会シンポジウム腸内フローラの臨床への展開
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-06-12
- Invited
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] 肥満誘導性の腸内細菌代謝物による肝星細胞の細胞老化・ＳＡＳＰと肝がんの促進2016
- Author(s)
  羅　智文、蒲池史卓、渡辺喜洋、大谷直子
- Organizer
  第39回日本分子生物学会年会　シンポジウム臓器老化による臓器間ネットワークの破綻を探る
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-12-02
- Invited
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] The role of gut microbiota for obesity-associated liver cancer progression.2016
- Author(s)
  Naoko Ohtani
- Organizer
  International Symposium of the Center for Animal Disease Models 2016 -Metabolic disease and Aging- Tokyo, Japan
- Place of Presentation
  Tokyo Garden Palace（Tokyo Japan）
- Year and Date
  2016-07-16
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] 肥満誘導性肝臓癌におけるinterleukin-33の役割解明2016
- Author(s)
  中村大、蒲池史卓、山崎翔太、新井達也、原田陽介、久保允人、羅智文、吉本真、中江進、原英二、大谷直子
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] IL-33 promotes obesity-associated liver cancer development2016
- Author(s)
  Fumitaka Kamachi, Shota Yamazaki, Tatsuya Arai, Yohsuke Harada, Masato Kubo, Susumu Nakae, and Naoko Ohtani
- Organizer
  第45回日本免疫学会学術集会The 45th Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  沖縄コンベンションセンター、（沖縄県宜野湾市）
- Year and Date
  2016-12-06
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] The mechanism of obesity-induced liver cancer development through gut microbial components and metabolites.2016
- Author(s)
  Naoko Ohtani
- Organizer
  Bridging Biomedical Worlds meeting, Frontiers in Human Microbiota Symbiotic Interactions
- Place of Presentation
  University of Hong Kong (Hong Kong, China)
- Year and Date
  2016-05-24
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] The role of gut microbiota for obesity-associated liver cancer progression.2016
- Author(s)
  Naoko Ohtani
- Organizer
  Tokyo University of Science, International Symposium of the Center for Animal Disease Models 2016 -Metabolic disease and Aging-.
- Place of Presentation
  Tokyo Garden Palace（Tokyo Japan）
- Year and Date
  2016-07-16
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12709
[Presentation] 規則的な運動は肥満誘導性肝腫瘍の発症を抑制する2016
- Author(s)
  熊谷実保、蒲池史卓、安藤達也、新井友里子、井手口真理、中村大、小澤崇之、渡辺喜洋、山埼翔太、羅智文、大谷直子
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-16H04699
[Presentation] Cooperative role of gut microbial components and metabolites in obesity-associated liver cancer development.2016
- Author(s)
  Tze Mun Loo and Naoko Ohtani
- Organizer
  The 75th Annual Meeting of the Japanese Cancer Association Symposium 10（日本癌学会）, Therapeutic vulnerability in infection/inflammation-associated cancer
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-10-07
- Invited
- Data Source
  KAKENHI-PROJECT-15K12709
[Presentation] The mechanism of obesity-induced liver cancer development through gut microbial components and metabolites.2016
- Author(s)
  Naoko Ohtani
- Organizer
  Bridging Biomedical Worlds meeting, Frontiers in Human Microbiota Symbiotic Interactions
- Place of Presentation
  University of Hong Kong (Hong Kong, China)
- Year and Date
  2016-05-24
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12709
[Presentation] The Mechanism of Obesity-associated Liver Carcinogenesis: a co-operation between gut microbial metabolites and lipid.2016
- Author(s)
  Naoko Ohtani
- Organizer
  EASL, European association for the study of the liver, The International Liver Congress 2016
- Place of Presentation
  Fira Barcelona Gran Via (Barcelona, Spain)
- Year and Date
  2016-04-14
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12709
[Presentation] 肥満による肝がん促進機構～腸内細菌代謝物の関与～2015
- Author(s)
  大谷直子
- Organizer
  第18回　日本臨床腸内微生物学会総会・学術集会　教育講演　III　病態と治療法を探る
- Place of Presentation
  日本医科大学附属病院橘桜会館（東京都）
- Year and Date
  2015-08-29
- Invited
- Data Source
  KAKENHI-PROJECT-15K12709
[Presentation] Gut microbiota and obesity-associated hepatocarcinogenesis, The 74th Annual meeting of The JCA2015
- Author(s)
  Naoko Ohtani
- Organizer
  日本癌学会
- Place of Presentation
  名古屋国際会議場（名古屋）
- Year and Date
  2015-10-09
- Invited
- Data Source
  KAKENHI-PROJECT-15K12709
[Presentation] Obesity-induced gut microbial metabolite promotes liver cancer through senencnce-associated secretome2015
- Author(s)
  Naoko Ohtani
- Organizer
  24th Symposium on Intestinal Flora, Dynamism of Intestinal microbiota - pathophysiology of microbial metabolites
- Place of Presentation
  ヤクルトホール（東京都）
- Year and Date
  2015-10-30
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12709
[Presentation] 腸内細菌代謝産物による細胞老化の誘導と肝がん2015
- Author(s)
  大谷直子
- Organizer
  第11回　日本食品免疫学会学術大会、シンポジウム３　「老化と腸内環境、腸管機能」
- Place of Presentation
  伊藤謝恩ホール（東京都）
- Year and Date
  2015-10-16
- Invited
- Data Source
  KAKENHI-PROJECT-15K12709
[Presentation] 肥満により増加する腸内細菌による肝がん促進機構2015
- Author(s)
  大谷直子、羅　智文
- Organizer
  第36回　日本肥満学会　シンポジウム「肥満と臓器障害」
- Place of Presentation
  名古屋国際会議場（名古屋）
- Year and Date
  2015-10-02
- Invited
- Data Source
  KAKENHI-PROJECT-15K12709
[Presentation] 細胞老化・SASPによる発がん-肥満により増加する腸内細菌の代謝産物DCAは肝がんを促進する-2014
- Author(s)
  大谷直子
- Organizer
  第23回日本小児胆汁酸研究会
- Year and Date
  2014-02-15
- Data Source
  KAKENHI-PROJECT-23300343
[Presentation] 肥満に伴い増加する腸内細菌の代謝産物デオキシコール酸によるSASPを介した肝がん促進作用2014
- Author(s)
  大谷直子, 吉本真, 羅智文, 原英二
- Organizer
  第47回日本無菌生物ノートバイオロジー学会総会シンポジウム
- Year and Date
  2014-01-31
- Data Source
  KAKENHI-PROJECT-23300343
[Presentation] 細胞老化による炎症とがん -肥満に伴い増加する腸内細菌の代謝産物による肝がん促進作用-2013
- Author(s)
  大谷直子, 吉本真, 羅智文, 原英二
- Organizer
  第36回日本分子生物学会年会ワークショップ「生老病死」の分子生物学の最前線
- Year and Date
  2013-12-03
- Data Source
  KAKENHI-PROJECT-23300343
[Presentation] The role of cellular senescence in obesity-associated hepatic carcinogenesis2013
- Author(s)
  Ohtani N, Hara E
- Organizer
  第72回日本癌学会総会シンポジウム Animal models in cancer research
- Year and Date
  2013-10-05
- Data Source
  KAKENHI-PROJECT-23300343
[Presentation] 細胞老化の二面性 -がん抑制機構SASP-2013
- Author(s)
  大谷直子
- Organizer
  第65回日本細胞生物学会大会シンポジウム老化の分子機構
- Year and Date
  2013-06-21
- Data Source
  KAKENHI-PROJECT-23300343
[Presentation] 肥満により増加する腸内細菌の代謝産物DCAは肝癌発症を促進する2013
- Author(s)
  大谷直子
- Organizer
  第1回がんと代謝研究会
- Year and Date
  2013-10-30
- Data Source
  KAKENHI-PROJECT-23300343
[Presentation] 細胞老化による炎症とがん-肥満により増加する腸内細菌の代謝産物が肝がんを促進する-2013
- Author(s)
  大谷直子
- Organizer
  第45回北陸実験動物研究会
- Year and Date
  2013-09-14
- Data Source
  KAKENHI-PROJECT-23300343
[Presentation] 肥満により増加する腸内細菌の代謝産物が肝がんを促進する2013
- Author(s)
  大谷直子
- Organizer
  第41回臨床免疫学会総会シンポジウム
- Year and Date
  2013-11-28
- Data Source
  KAKENHI-PROJECT-23300343
[Presentation] Senescence-associated inflammatory secretome and cancer development2013
- Author(s)
  Naoko Ohtani
- Organizer
  JST-CREST International Symposium "Frontiers in Immunology and Inflammation"
- Year and Date
  2013-02-13
- Data Source
  KAKENHI-PROJECT-23300343
[Presentation] Obesity-induced gut microbial metabolite promotes liver cancer via senescence secretome2013
- Author(s)
  Naoko Ohtani, Shin Yoshimoto, Tze Mun Loo, Hiroaki Kanda, Seidai Sato, Yuichi Ishikawa and Eiji Hara
- Organizer
  Welcome Trust scientific conference. Cell Senescence in Cancer and Aging
- Year and Date
  2013-07-22
- Data Source
  KAKENHI-PROJECT-23300343
[Presentation] Cellular senescence-associated inflammation and cancer2012
- Author(s)
  Naoko Ohtani
- Organizer
  2nd Japanese-French Cancer Workshop
- Year and Date
  2012-11-29
- Data Source
  KAKENHI-PROJECT-23300343
[Presentation] Senescence-Associated Secretory Phenotypes (SASPs) Promote Obesity Associated Hepatocarcinogenesis2012
- Author(s)
  Naoko Ohtani
- Organizer
  Keystone Symposia "Aging and Dideases of Aging"
- Year and Date
  2012-10-25
- Data Source
  KAKENHI-PROJECT-23300343
[Presentation] Senescence-associated secretory phenotype (SASP) in fatty-liver based hepatic cancer2011
- Author(s)
  Naoko Ohtani, Shin Yoshimoto, Eiji Hara
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-23300343
[Presentation] Senescence-associated secretory phenotype (SASP) in fatty-liver based hepatic cancer2011
- Author(s)
  Naoko Ohtani, Shin Yoshimoto, Eiji Hara
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PUBLICLY-22019042
[Presentation] Intrinsic cooperation between p16^<Ink4a> and p21^<Waf/Cip1> in the onset of cellular senescence and tumor suppression in vivo.2010
- Author(s)
  Takeuchi S, Takahashi A, Motoi N, Yoshimoto S, Tajima T, Yamakoshi K, Ishikawa Y, Sone S, Hara E., Ohtani N.
- Organizer
  Cold Spring Harbor Laboratory Meeting, Molecular Genetics of Aging
- Place of Presentation
  Cold Spring Harbor, NewYork, USA
- Year and Date
  2010-09-29
- Data Source
  KAKENHI-PROJECT-20300229
[Presentation] Identification of tumor stimulating factors in cellular senescence.2010
- Author(s)
  Imai Y, Takahashi A, Yao R, Ohtani N, HirotaT, Tahara H, Ide T, Noda T, Hara E
- Organizer
  日本癌学会総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-20300229
[Presentation] Intrinsic cooperation between p16^<Ink4a> and p21^<Waf/Cip1> in the onset of cellular senescence and tumor suppression in vivo.2010
- Author(s)
  Takeuchi S, Takahashi A, Motoi N, Yoshimoto S, Tajima T, Yamakoshi K, Ishikawa Y, Sone S, Hara E., Ohtani N
- Organizer
  Cold Spring Harbor Laboratory Meeting, Molecular Genetics of Aging Cold Spring Harbor
- Place of Presentation
  New York, USA
- Year and Date
  2010-09-29
- Data Source
  KAKENHI-PROJECT-20300229
[Presentation] Intrinsic cooperation between p16^<Ink4a> and p21^<Waf/Cip1> in the onset of cellular senescence and tumor suppression in vivo.2010
- Author(s)
  Takeuchi S, Takahashi A, Motoi N, Yoshimoto S, Tajima T, Yamakoshi K, Ishikawa Y, Sone S, Hara E., Ohtani N.
- Organizer
  Cold Spring Harbor Laboratory Meeting, Molecular Genetics of Aging
- Place of Presentation
  Cold Spring Harbor, New York, USA
- Year and Date
  2010-09-29
- Data Source
  KAKENHI-PUBLICLY-22019042
[Presentation] Visualizing the dynamics of Oncogenic stress response in living mice.2009
- Author(s)
  Naoko Ohtani
- Organizer
  American Association for cancer Research (AACR) special conference in Cancer Research: Mouse Models of Cancer
- Place of Presentation
  米国サンフランシスコ Hyatt Regency
- Year and Date
  2009-01-13
- Data Source
  KAKENHI-PROJECT-20058027
[Presentation] Real-time in vivo imaging of oncogenic stress response in living animals.2009
- Author(s)
  大谷直子
- Organizer
  Cell Proliferation Control International Symposium CELL CYCLE and CELL ARCHITECTURE
- Place of Presentation
  Nagoya(招待講演)
- Year and Date
  2009-02-28
- Data Source
  KAKENHI-PROJECT-20300229
[Presentation] Cooperative role of p21^<Waf1/Cip1> and p16^<INK4a> in skin cancer prevention in mice2009
- Author(s)
  Takeuchi S, Takahashi A, Motoi N, Yamakoshi K, Ishikawa Y, Sone S, Hara E, Ohtani N
- Organizer
  日本癌学会総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-20300229
[Presentation] Real-time in vivo imaging of p16^<INK4a> expression unveils a cross-talk between p53 and p16^<INK4a>2009
- Author(s)
  Yamakoshi K, Takahashi A, Ohtani N, Hara E
- Organizer
  Salk Institute, Mechanism & Models of Cancer meeting
- Place of Presentation
  La Jolla, U.S.A.
- Year and Date
  2009-08-14
- Data Source
  KAKENHI-PROJECT-20300229
[Presentation] 癌抑制機構としての細胞老化2009
- Author(s)
  大谷直子
- Organizer
  日本再生医療学会シンポジウム、ステムセルエイジング
- Place of Presentation
  東京(招待講演)
- Year and Date
  2009-03-05
- Data Source
  KAKENHI-PROJECT-20300229
[Presentation] Visualizing the dynamics of Oncogenic stress response in living mice2009
- Author(s)
  Naoko Ohtani
- Organizer
  American Association for cancer Research (AACR) special conference in Cancer Research : Mouse Models of Cancer
- Place of Presentation
  米国サンフランンシスコ Hyatt Regency
- Year and Date
  2009-01-13
- Data Source
  KAKENHI-PROJECT-20300229
[Presentation] The role of cellular senescence in obesity-associated hepatic carcinogenesis
- Author(s)
  Naoko Ohtani and Eiji Hara
- Organizer
  第72回日本癌学会総会シンポジウム
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-23300343
[Presentation] Senescence-Associated Secretory Phenotypes(SASPs) Promote Obesity Associated Hepatocarcinogenesis
- Author(s)
  Naoko Ohtani
- Organizer
  Keystone Symposia〝Aging and Dideases of Aging″
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-23300343
[Presentation] 肥満により増加する腸内細菌の代謝産物ＤＣＡは肝がん発症を促進する
- Author(s)
  大谷直子
- Organizer
  第１回がんと代謝研究会　特別講演
- Place of Presentation
  鶴岡
- Invited
- Data Source
  KAKENHI-PROJECT-23300343
[Presentation] Induction of cellular senescence in obesity-associated hepatic carcinogenesis
- Author(s)
  Shin Yoshimoto, Tze Mun Loo, Hiroaki Kanda, Seidai Sato, Yuichi Ishikawa, Eiji Hara & Naoko Ohtani
- Organizer
  Keystone Symposia〝The Role of Inflammation during Carcinogenesis″
- Place of Presentation
  Dublin, Ireland
- Data Source
  KAKENHI-PROJECT-23300343
[Presentation] Cellular senescence-associated inflammation and cancer
- Author(s)
  Naoko Ohtani
- Organizer
  2nd Japanese-French Cancer Workshop
- Place of Presentation
  Naruto, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-23300343
[Presentation] 細胞老化による炎症とがん－肥満に伴い増加する腸内細菌の代謝産物による肝がん促進作用－
- Author(s)
  大谷直子
- Organizer
  第36回分子生物学会年会ワークショップ
- Place of Presentation
  神戸
- Invited
- Data Source
  KAKENHI-PROJECT-23300343
[Presentation] Senescence-associated inflammatory secretome and cancer development
- Author(s)
  Naoko Ohtani
- Organizer
  JST-CREST International Symposium　〝Frontiers in Immunology and Inflammation″
- Place of Presentation
  Tokyo, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-23300343
[Presentation] 肥満により増加する腸内細菌の代謝産物が肝がんを促進する
- Author(s)
  大谷直子
- Organizer
  第41回日本臨床免疫学会総会シンポジウム
- Place of Presentation
  下関
- Invited
- Data Source
  KAKENHI-PROJECT-23300343

1. KUBO Yoshiaki (10260069)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
2. HIDA Yasutoshi (90380039)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. HARA Eiji (80263268)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
4. TAKUBO Keiyo (50502788)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. ROKUTAN Kazuhito (10230898)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. FUKUO Keisuke (40156758)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 酒井敏行 (20186993)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 村尾和俊 (40363171)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 蒲池史卓 (00747800)

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
10. 安田修 (00372615)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 西川浩樹 (30769609)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 榎本平之 (40449880)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 横路三有紀 (80757188)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 藤井英樹 (20382070)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 翁良徳 (10964900)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 中台枝里子 (40453790)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 和田崇之 (70332450)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 山口良弘 (00737009)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 橋本求 (60512845)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 岡野匡志 (50754826)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 西川博嘉 (10444431)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 小山正平 (80767559)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 鈴木信弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 及川大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 池田一雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 松原勤

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
27. 宇留島隼人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 三木裕明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 河本新平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 河田則文

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
31. LE Thuy

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. HOANG HAI

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 有田誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 有田正規

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 杉本幸彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 高杉征樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 脇田隆字

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 松原三佐子(佐藤三佐子)

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 神谷知憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 鈴木聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 近藤恭光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohtani Naoko 大谷 直子

OHTANI Naoko 大谷 直子

藤田 直子 フジタ ナオコ

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Liver cancer suppression by regular exercise: Focusing on the degradation of oncometabolitePrincipal Investigator

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The molecular mechanism of the inhibitory effect of liver cancer development via inter-organ relationship by regular exercise: its application to cancer preventionPrincipal Investigator

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The mechanism of obesity-associated liver cancer progression through cytokine cross-talk in tumor microenvironment.Principal Investigator

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The effect of regular exercise on obesity-associated liver cancer from the aspect of gut microbiota and lipid metabolitesPrincipal Investigator

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The molecular mechanism of senescence-associated prolongation of inflammatory signaling and its effect on cancer micro-environments.Principal Investigator

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メタボリックストレス応答におけるCDKインヒビターの役割Principal Investigator

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分子イメージングを利用したCDKインヒビターp21の生体内機能の解明Principal Investigator

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Mechanism of Tumor formation by deregulated circadian rhythm and strategy for its preventionPrincipal Investigator

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Ohtani Naoko 大谷直子

OHTANI Naoko 大谷直子

藤田直子フジタナオコ

[Book] 消化器疾患の最新医療　トピックス　腸内細菌と消化器がん2018

[Book] 組織幹細胞の老化(佐方功幸、稲垣昌樹、岸本武雄編集)(細胞周期フロンティア)2010