TSUNO Hirokazu 津野寛和

… Alternative Names

TSUNO Nelson 津野ネルソン

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Researcher Number	50282637
Affiliation (based on the past Project Information) *help	2016: 東京大学, 医学部附属病院, 客員研究員 2015: 東京大学, 医学部附属病院, 研究員 2012 – 2014: 東京大学, 医学部附属病院, 講師 2007 – 2008: The University of Tokyo, 医学部・附属病院, 助教 2006 – 2007: 東京大学, 医学部附属病院, 助教 … More 2005 – 2006: 東京大学, 医学部附属病院, 助手 2002 – 2003: 東京大学, 医学部附属病院, 助手 1996 – 2001: 東京大学, 医学部・附属病院, 助手 1999: 東京大学, 医学部・付属病院, 助手 1997 – 1998: 東京大学, 医学部附属病院, 助手 1997: Tokyo Univ.Dept.of Transfusion Medicine, Instructor, 医学部・付属病院・輸血部, 助手 Less
Review Section/Research Field	Principal Investigator Applied pharmacology / Laboratory medicine / General surgery Except Principal Investigator General surgery / Digestive surgery / Laboratory medicine / Digestive surgery / Biological Sciences / Tumor diagnosis
Keywords	Principal Investigator 内皮細胞 / プラウノトール / 血管新生 / 胃癌 / 大腸癌 / 複合的抗癌治療 / 複合的抗癌薬 / 自己抗体 / 自己免疫疾患 / MPHA … More / 血小板特異抗原(HPA) / フローサイトメトリー / Western Blotting / Western Biotting / 抗内皮細胞抗体 / MPHA法 / Human Platelet Antigen (HPA) / 臓器移植 / Endothelial cells / Autoantibodies / Autommune diseases / Mixed-passive hemagglutination (MPHA) assay / Human platelet antigens (HPAs) / Flow-cytometry / Western blotting / 腫瘍血管 / 抗体 / 癌治療 / 癌 / 治療 / 血管内皮細胞 / モノクローナル抗体 / Tumor Endothelium / Endothelial Cells / Monoclonal Antibodies / Cancer Treatment … More Except Principal Investigator 樹状細胞 / 大腸癌 / 免疫療法 / 腫瘍抗原 / RNA / 血小板型 / HPA / 癌転移 / 血小板抗体 / 血小板輸血 / 新生児血小板減少紫斑病 / 血小板輸血不応答 / Platelet Allo-antibody / Platelet Transfusion / Neonatal Alloimmune Thrombocytopenia / CXCR4 / COX-2 / LPA / 遺伝子導入 / 癌 / アロタイプ / 血行性転移 / 接着分子 / ハプロタイプ / 腫瘍血管 / 血管内皮細胞 / スルフォラファン / ゾレドロン酸 / 選択性セロトニン受容体阻害薬 / 血管内皮前駆細胞 / HLA / 集学的治療 / 個別化治療 / ワクチン / Surforaphane / HUVEC / 内皮細胞 / hRFI / 抗癌剤感受性 / アポトーシス / p53 / 血管新生阻害 / HSE / 大腸がん / バイオマーカー / 血中遊離DNA / LINE1 / 腫瘍マーカー / 放射線療法 / SN-38 / HIF-1α / 化学放射線療法 / 直腸癌 / CPT-11 / 新生児血小板減少性紫斑病 / 血小板抗原 / MPHA / Platelet Allo-antigen / 消化器癌 / サイトカイン / Immunotherapy / Dendritic Cell / Tumor Antigen / Gastrointestinal Cancer / Cytokine / ケモカイン / MIP1β / 胃癌 / 免疫染色 / MIPIβ / Chemokine / MIP-1β / Gastric Cancer / Immunohistochemistry / 血小板(HPA) / 新生児血小板減少症紫斑病 / Pletelet Allo-antigen / 細胞障害性Tリンパ球 / dendritic cell / immunotherapy / cytotoxic T lymphocyte / colon cancer / tumor antigen / 血管新生 / sFlt1 / カテキン / S1P / VEGF-L / P16 / sFlt-1 / Edg / VEGF / リンパ管内皮 / VEGF-C / VEGF-D / shear stress / metastasis / angiogenesis / s-Flt-1 / catechin / SIP Less

SN-38 as a radio-sensitizer for colorectal cancer by suppressing radiation-induced HIF-1a overexpression
- Principal Investigator
  
  Kawai Kazushige
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  The University of Tokyo
Clinical utilization of teh cell free DNA as tumor biomarker.
- Principal Investigator
  
  EIJI SUNAMI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor diagnosis
- Research Institution
  The University of Tokyo
植物由来イソプレノイドの抗腫瘍効果および抗血管新生作用についての検討Principal Investigator
- Principal Investigator
  
  津野寛和
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Applied pharmacology
- Research Institution
  The University of Tokyo
Treatment strategy for colorectal cancer targeted to the tumor vessel
- Principal Investigator
  
  NAGAWA Hirokazu
- Project Period (FY)
  2005 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  The University of Tokyo
Synthetic analysis of metastasis related molecules from clinical point of view.
- Principal Investigator
  
  NAGAWA Hirokazu
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General surgery
- Research Institution
  The University of Tokyo
腫瘍抽出RNAの導入樹状細胞を用いた抗腫瘍免疫療法の開発
- Principal Investigator
  
  OSADA Takuya
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
癌の血行性転移と血小板型(HPA)との相関性についての臨床的検討
- Principal Investigator
  
  名川弘一
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  The University of Tokyo
Development of a New Stragegy for Cancer Treatment by Targeting Tumor Vascular Endothelium Using Monoclonal AntibodiesPrincipal Investigator
- Principal Investigator
  
  TSUNO Hirokazu
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  The University of Tokyo
Establishment of the anti-tumor immunotherapy using dendritic cells transfected with tumor extracted RNA
- Principal Investigator
  
  OSADA Takuya
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  The University of Tokyo
Expression of chemokines in gastrointestinal cancer
- Principal Investigator
  
  SETO Yasuyuki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  The University of Tokyo
Screening of anti-platelet antibodies and prospective study of neonatal alloimmune thrombocytopenia
- Principal Investigator
  
  SHIBATA Yoichi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  The University of Tokyo
Establishment of New Immunotheapy using Dendritic Cells and Evaluation of Its Inhibitory Effect on Tumor Relapse.
- Principal Investigator
  
  OSADA Takuya
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  University of Tokyo
Development of a new anti-endothelial cell antibody detection system and investigation on its clinical significance.Principal Investigator
- Principal Investigator
  
  TSUNO Nelson
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  The University of Tokyo
Development of MPHA kit for detecting antiplatelet antibodies.
- Principal Investigator
  
  SHIBATA Yoichi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Laboratory medicine
- Research Institution
  University of Tokyo

All 2015 2014 2009 2008 2007 2006 2005

All Journal Article Presentation

[Journal Article] Prediction of the preoperative chemoradiotherapy response for rectal cancer by peripheral blood lymphocyte subsets.2015
- Author(s)
  Tada N, Kawai K, Tsuno NH, Ishihara S, Yamaguchi H, Sunami E, Kitayama J, Oba K, Watanabe T.
- Journal Title
  
  World J Surg Oncol
  
  Volume: 13 Pages: 30-30
- DOI
  10.1186/s12957-014-0418-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24300337, KAKENHI-PROJECT-25253080
[Journal Article] Characteristics and prognosis of colorectal cancer associated with rheumatic disease.2015
- Author(s)
  Kishikawa J, Kawai K, Tsuno N, Yamaguchi H, Ishihara S, Sunami E, Watanabe T.
- Journal Title
  
  Int Surg
  
  Volume: [Epub ahead of print
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24300337
[Journal Article] Phosphatidylserine-specific phospholipase A1 (PS-PLA1) expression in colorectal cancer correlates with tumor invasion and hematogenous metastasis.2015
- Author(s)
  Iida Y, Sunami E, Yamashita H, Hiyoshi M, Ishihara S, Yamaguchi H, Inoue A, Makide K, Tsuno NH, Aoki J, Kitayama J, Watanabe T.
- Journal Title
  
  Anticancer Res
  
  Volume: 35 Pages: 1459-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24300337
[Journal Article] Proximal shift of colorectal cancer along with aging.2014
- Author(s)
  Iida Y, Kawai K, Tsuno NH, Ishihara S, Yamaguchi H, Sunami E, Kitayama J, Watanabe T.
- Journal Title
  
  Clin Colorectal Cancer.
  
  Volume: 13 Pages: 213-218
- DOI
  10.1016/j.clcc.2014.06.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24300337, KAKENHI-PROJECT-24591984
[Journal Article] Changes in the plasma levels of cytokines/chemokines for predicting the response to chemoradiation therapy in rectal cancer patients.2014
- Author(s)
  Tada N, Tsuno NH, Kawai K, Murono K, Nirei T, Ishihara S, Sunami E, Kitayama J, Watanabe T.
- Journal Title
  
  Oncol Rep.
  
  Volume: 31 Pages: 463-71
- DOI
  10.3892/or.2013.2857
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24300337, KAKENHI-PROJECT-24390309, KAKENHI-PROJECT-24659620, KAKENHI-PROJECT-25253080
[Journal Article] Sulforaphane stimulates activation of proapoptotic protein bax leading to apoptosis of endothelial progenitor cells2009
- Author(s)
  Nishikawa T. Tsuno NH. Tsuchiya T. Yoneyama S. Yamada J. Shuno Y. Okaji Y. Tanaka J. Kitayama J. Takahashi K. Nagawa H.
- Journal Title
  
  Annals of Surgical Oncology 16(2)
  
  Pages: 534-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209045
[Journal Article] Anti-angiogenic property of zoledronic acid by inhibition of endothelial progenitor cell differentiation2009
- Author(s)
  Yamada J. Tsuno NH. Kitayama J. Tsuchiya T. Yoneyama S. Asakage M. Okaji Y. Shuno Y. Nishikawa T. Tanaka J. Takahashi K. Nagawa H.
- Journal Title
  
  Journal of Surgical Research 151(1)
  
  Pages: 115-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209045
[Journal Article] Pilot study of anti-angiogenic vaccine using fixed whole endothelium in patients with progressive malignancy after failure of conventional therapy2008
- Author(s)
  Okaji Y, Tsuno NH, Tanaka M, Yoneyama S, Matsuhashi M, Kitayama J.. Saito S, Nagura Y, Tsuchiya T, Yamada J, Tanaka J, Yoshikawa N, Nishikawa T, Shuno Y, Todo T, Saito N, Takahashi K, Nagawa H.
- Journal Title
  
  Eur J Cancer 44(3)
  
  Pages: 383-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209045
[Journal Article] Plaunotol induces apoptosis of gastric cancer cells.2007
- Author(s)
  Yamada J, Tsuno NH, 他
- Journal Title
  
  Planta Medica 73(10)
  
  Pages: 1068-1073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659156
[Journal Article] A study of dendritic and endothelial cell interactions in colon cancer in a cell line and small mammal model2007
- Author(s)
  Yoneyama S. Okaji Y. Tsuno NH. Kawai K. Yamashita H. Tsuchiya T. Yamada J. Sunami E. Osada T. Kitayama J. Takahashi K. Nagawa H.
- Journal Title
  
  Eur J Surg Oncol 33(10)
  
  Pages: 1191-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209045
[Journal Article] Early-outgrowth of endothelial progenitor cells can function as antigen-presenting cells2006
- Author(s)
  Asakage M. Tsuno NH. Kitayama J. Kawai K. Okaji Y. Yazawa K. Kaisaki S. Osada T. Watanabe T. Takahashi K. Nagawa H.
- Journal Title
  
  Cancer Immunology, Immunotherapy 55(6)
  
  Pages: 708-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209045
[Journal Article] Sulforaphane induces inhibition of human umbilical vein endothelial cells proliferation by apoptosis2006
- Author(s)
  Asakage M. Tsuno NH. Kitayama J. Tsuchiya T. Yoneyama S. Yamada J. Okaji Y. Kaisaki S. Osada T. Takahashi K. Nagawa H.
- Journal Title
  
  Angiogenesis 9(2)
  
  Pages: 83-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209045
[Journal Article] 先端のバイオ研究を知る2005
- Author(s)
  大梶祐頼, 津野寛和, 高橋孝喜, 名川弘一
- Journal Title
  
  テクノ・トレンド新たな癌治療法の開発腫瘍血管内皮細胞・腫瘍内マクロファージの選択的分離についてバイオテクノロジージャーナル 5(4)
  
  Pages: 457-459
- Data Source
  KAKENHI-PROJECT-17209045
[Journal Article] 腫瘍血管内皮細胞を標的とした新たな癌治療法の開発2005
- Author(s)
  津野寛和
- Journal Title
  
  日本臨床(増刊号) 63(9)
  
  Pages: 527-33
- Data Source
  KAKENHI-PROJECT-17209045
[Journal Article] Anti-angiogenic properties of plaunotol.2005
- Author(s)
  Kawai K, Tsuno NH, Kitayama J, Takahashi K, Nagawa H, et al.
- Journal Title
  
  Anticancer Drugs. 2005 Apr;16(4) : 401-7. 16(4)
  
  Pages: 401-407
- Data Source
  KAKENHI-PROJECT-18659156
[Presentation] 選択的5-HT4受容体アゴニストによる抗血管新生作用2008
- Author(s)
  西川武司, 津野寛和, 須並英二, 北山丈二, 高橋孝喜, 名川弘一
- Organizer
  第67回日本癌学会総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-17209045
[Presentation] ゾレドロン酸による血管内皮前駆細胞を標的とした抗血管新生療法2007
- Author(s)
  山田純, 北山丈二, 津野寛和, 米山さとみ, 土屋剛史, 朝陰正宏, 名川弘一
- Organizer
  第65回日本癌学会総会
- Place of Presentation
  横浜
- Year and Date
  2007-09-30
- Data Source
  KAKENHI-PROJECT-17209045
[Presentation] 腫瘍血管の形成スルフォラファンは前アポトーシスタンパク質Baxを活性化し内皮前駆細胞のアポトーシスを誘導する2007
- Author(s)
  西川武司, 津野寛和, 高橋孝喜, 北山丈二, 名川弘一
- Organizer
  第66回日本癌学会総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-04
- Data Source
  KAKENHI-PROJECT-17209045
[Presentation] 癌に対する血管新生標的治療の現状と将来内皮細胞ワクチンは腫瘍血管内皮細胞に対する免疫応答を誘導する2007
- Author(s)
  津野寛和, 他
- Organizer
  日本外科学会
- Place of Presentation
  大阪
- Year and Date
  2007-03-29
- Data Source
  KAKENHI-PROJECT-17209045
[Presentation] スルフォラファンのアポトーシスによる内皮細胞増殖抑制2006
- Author(s)
  朝蔭正宏, 津野寛和, 北山丈二, 川合一茂, 谷澤健太郎, 大梶祐頼, 土屋剛史, 米山さとみ, 山田純, 高橋孝喜, 名川弘一
- Organizer
  第64回日本癌学会総会
- Year and Date
  2006-09-29
- Data Source
  KAKENHI-PROJECT-17209045
[Presentation] 癌に対する血管新生標的治療の現状と将来内皮細胞ワクチンは腫瘍血管内皮細胞に対する免疫応答を誘導する2006
- Author(s)
  津野寛和, 大梶祐頼, 朝蔭正宏, 田中実, 米山さとみ, 土屋剛史, 山田純, 北山丈二, 藤堂具紀, 渡辺聡明, 名川弘一, 高橋孝喜
- Organizer
  第107回日本外科学会
- Place of Presentation
  東京
- Year and Date
  2006-03-31
- Data Source
  KAKENHI-PROJECT-17209045

1. KITAYAMA Joji (20251308)

# of Collaborated Projects: 8 results

# of Collaborated Products: 13 results
2. SHIBATA Yoichi (30010474)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
3. NAGAWA Hirokazu (80228064)

# of Collaborated Projects: 8 results

# of Collaborated Products: 13 results
4. OSADA Takuya (90272559)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. TAKAHASHI Koki (50171484)

# of Collaborated Projects: 4 results

# of Collaborated Products: 12 results
6. SUNAMI Eiji (70345205)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
7. WATANABE Toshiaki (80210920)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
8. TAKAMIZAWA Masaru (40216784)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. TAKEI Yoshiki (10372369)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. KAWAI Kazushige (80571942)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
11. KANO Kyoichi (80152825)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. JUJI Takeo (20009997)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MUTO Tetsuichirou (20110695)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SETO Yasuyuki (00260498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. SASAKI Shin (00292946)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 釣田義一郎 (80345206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 上條亜紀 (30361489)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 石原聡一郎 (00376443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 山口博紀 (20376445)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 鶴尾隆 (00012667)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 甲斐崎祥一 (70291325)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 堀信一 (90282631)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 石黒達昌 (90292945)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 波多野賢二

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 松田圭二

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TSUNO Hirokazu 津野 寛和

TSUNO Nelson 津野 ネルソン

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植物由来イソプレノイドの抗腫瘍効果および抗血管新生作用についての検討Principal Investigator

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Development of a New Stragegy for Cancer Treatment by Targeting Tumor Vascular Endothelium Using Monoclonal AntibodiesPrincipal Investigator

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Development of a new anti-endothelial cell antibody detection system and investigation on its clinical significance.Principal Investigator

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[Journal Article] Prediction of the preoperative chemoradiotherapy response for rectal cancer by peripheral blood lymphocyte subsets.2015

Author(s)

TSUNO Hirokazu 津野寛和

TSUNO Nelson 津野ネルソン