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YAMANAKA SATOSHI  山中 聡士

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Yamanaka Satoshi  山中 聡士

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Researcher Number 50853884
Other IDs
Affiliation (Current) 2026: 愛媛大学, プロテオサイエンスセンター, 特定助教
Affiliation (based on the past Project Information) *help 2022 – 2025: 愛媛大学, プロテオサイエンスセンター, 特定助教
2021: 愛媛大学, プロテオサイエンスセンター, 特定研究員
Review Section/Research Field
Principal Investigator
Basic Section 43060:System genome science-related / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Complex systems
Except Principal Investigator
Basic Section 54020:Connective tissue disease and allergy-related / Basic Section 47060:Clinical pharmacy-related / Basic Section 37030:Chemical biology-related / Transformative Research Areas, Section (III) / Medium-sized Section 49:Pathology, infection/immunology, and related fields
Keywords
Principal Investigator
タンパク質分解 / CRBN / サリドマイド / ユビキチン / 近接ビオチン化酵素 / 近位依存性ビオチン標識 / ゲノム編集マウス / タンパク質分解薬 / プロテアソーム / E3ユビキチンリガーゼ / 近位依存性ビオチン標識法 / PROTAC … More
Except Principal Investigator
… More 創薬 / ヒト多能性幹細胞 / コバレントドラッグ / タンパク質分解制御 / E3アダプタータンパク質 / IQGAP1 / CRBN / ステープルペプチド / アプタマー / LYTAC / サリドマイド / タンパク質分解薬 / E3ユビキチンリガーゼ / CRBNモジュレーター / PROTAC / タンパク質アレイ / 疾患インララクトーム / 疾患インタラクトーム / ヒトタンパク質アレイ / 自己炎症疾患 / 赤血球侵入 / マラリア / 滑走運動 / メロゾイト / マラリア原虫 Less
  • Research Projects

    (11 results)
  • Research Products

    (12 results)
  • Co-Researchers

    (28 People)
  •  コバレント・スタビライザーが拓く細胞内タンパク質発現制御技術の新展開

    • Principal Investigator
      宮前 友策
    • Project Period (FY)
      2025 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 37030:Chemical biology-related
    • Research Institution
      University of Tsukuba
  •  近接ビオチン標識法を基盤とした生体内における薬剤相互作用動態の解析技術の開発Principal Investigator

    • Principal Investigator
      山中 聡士
    • Project Period (FY)
      2025 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 43060:System genome science-related
    • Research Institution
      Ehime University
  •  ヒト肉腫オルガノイドを利用した薬剤スクリーニング技術の開発

    • Principal Investigator
      宝田 剛志
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Okayama University
  •  Development of Next-Generation Therapeutics for Systemic Lupus Erythematosus Utilizing Biobanks and National Registries

    • Principal Investigator
      松本 佳則
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 54020:Connective tissue disease and allergy-related
    • Research Institution
      Okayama University
  •  タンパク質分解薬創薬に向けた分解酵素結合化合物の同定法の確立Principal Investigator

    • Principal Investigator
      山中 聡士
    • Project Period (FY)
      2025 – 2026
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
    • Research Institution
      Ehime University
  •  Comprehensive disease-associated interactome and model mice elucidate diversity and periodicity of the autoinflammatory disease

    • Principal Investigator
      増本 純也
    • Project Period (FY)
      2024 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 54020:Connective tissue disease and allergy-related
    • Research Institution
      Ehime University
  •  Analysis of thalidomide-induced teratogenicity using genome-edited micePrincipal Investigator

    • Principal Investigator
      Yamanaka Satoshi
    • Project Period (FY)
      2023 – 2024
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 43060:System genome science-related
    • Research Institution
      Ehime University
  •  Controlling the lifetime of proteins using chemical degraders

    • Principal Investigator
      出水 庸介
    • Project Period (FY)
      2023 – 2027
    • Research Category
      Grant-in-Aid for Transformative Research Areas (A)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      National Institute of Health Sciences
  •  Molecular mechanisms of gliding motility in Plasmodium merozoites

    • Principal Investigator
      矢幡 一英
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 49:Pathology, infection/immunology, and related fields
    • Research Institution
      Ehime University
  •  近接ビオチン化酵素を用いたPROTAC依存的なインタラクトーム解析技術の開発Principal Investigator

    • Principal Investigator
      山中 聡士
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      Ehime University
  •  Development of analysis method for thalidomide-dependent interactome using proximity-dependent biotinylation enzymePrincipal Investigator

    • Principal Investigator
      Yamanaka Satoshi
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 43060:System genome science-related
    • Research Institution
      Ehime University

All 2024 2022 2021

All Journal Article Presentation Book

  • [Book] リアルな相互作用を捉える近接依存性標識プロトコール2024

    • Author(s)
      山中聡士
    • Total Pages
      16
    • Publisher
      羊土社
    • ISBN
      9784758122740
    • Data Source
      KAKENHI-PLANNED-23H04926
  • [Book] 医薬品モダリティにおける創薬技術開発と展望2024

    • Author(s)
      山中聡士
    • Total Pages
      1
    • Publisher
      情報機構
    • ISBN
      9784865022711
    • Data Source
      KAKENHI-PLANNED-23H04926
  • [Journal Article] Cell-type specific, inducible and acute degradation of targeted protein in mice by two degron systems2024

    • Author(s)
      Yamashita Motoi、Ogawa Chihiro、Zhang Baihao、Kobayashi Tetsuro、Nomura Aneela、Barker Clive、Zou Chengcheng、Yamanaka Satoshi、Hayashi Ken-ichiro、Shinkai Yoichi、Moro Kazuyo、Fargarasan Sidonia、Imami Koshi、Seita Jun、Shirai Fumiyuki、Sawasaki Tatsuya、Kanemaki Masato T.、Taniuchi Ichiro
    • Journal Title

      Nature Communications

      Volume: 15 Issue: 1 Pages: 10129-10129

    • DOI

      10.1038/s41467-024-54308-9

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-23H04926, KAKENHI-PROJECT-21H04719, KAKENHI-PROJECT-22H00413, KAKENHI-PROJECT-24H00560, KAKENHI-PROJECT-24H00632, KAKENHI-PROJECT-23K14171, KAKENHI-PROJECT-24K18475, KAKENHI-PROJECT-22K21354
  • [Journal Article] A proximity biotinylation-based approach to identify protein-E3 ligase interactions induced by PROTACs and molecular glues2022

    • Author(s)
      Yamanaka Satoshi、Horiuchi Yuto、Matsuoka Saya、Kido Kohki、Nishino Kohei、Maeno Mayaka、Shibata Norio、Kosako Hidetaka、Sawasaki Tatsuya
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 183-183

    • DOI

      10.1038/s41467-021-27818-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-21H00285, KAKENHI-PROJECT-19H03218, KAKENHI-PROJECT-20H02951, KAKENHI-PROJECT-20K06628, KAKENHI-PROJECT-21K19230, KAKENHI-PROJECT-21K15076
  • [Presentation] 近位依存性ビオチン化酵素を用いたタンパク質分解薬依存的な相互作用解析2024

    • Author(s)
      山中 聡士, 長岡 昂冶, 庄屋 祐希, 西野 耕平, 小迫 英尊, 澤崎達也
    • Organizer
      第47回日本分子生物学会年会
    • Data Source
      KAKENHI-PLANNED-23H04926
  • [Presentation] Development of thalidomide derivatives for controlling neosubstrate degradation2024

    • Author(s)
      Satoshi Yamanaka, Hirotake Furihata, Mai Usui, Koya Nagaoka, Yuki Shoya, Kohei Nishino, Hidetaka Kosako, Masaru Tanokura, Takuya Miyakawa, Norio Shibata, Tatsuya Sawasaki
    • Organizer
      19th ANNUAL Drug Discovery Chemistry
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-23H04926
  • [Presentation] 近位依存性ビオチン化酵素を用いたタンパク質分解誘導剤依存的な相互作用解析2022

    • Author(s)
      山中 聡士、堀内 雄斗、西野 耕平、小迫 英尊、澤崎 達也
    • Organizer
      第95回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-21K15076
  • [Presentation] 近位依存性ビオチン化酵素を用いたタンパク質分解誘導剤依存的な相互作用解析2022

    • Author(s)
      山中 聡士、堀内 雄斗、西野 耕平、小迫 英尊、澤崎 達也
    • Organizer
      第95回日本生化学会大会
    • Data Source
      KAKENHI-PUBLICLY-21H00285
  • [Presentation] 近位依存性ビオチン化酵素AirIDを用いたタンパク質分解誘導剤依存的なビオチン標識解析2022

    • Author(s)
      堀内雄斗、山中聡士、西野耕平、小迫英尊、澤崎達也
    • Organizer
      第45回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-21K15076
  • [Presentation] 近位依存性ビオチン化酵素AirIDを用いたタンパク質分解誘導剤依存的なビオチン標識解析2022

    • Author(s)
      堀内雄斗、山中聡士、西野耕平、小迫英尊、澤崎達也
    • Organizer
      第45回日本分子生物学会年会
    • Data Source
      KAKENHI-PUBLICLY-21H00285
  • [Presentation] 新規近接ビオチン化酵素AirIDを用いたタンパク質分解誘導剤依存的なインタラクトーム解析技術の開発2021

    • Author(s)
      山中 聡士、堀内 雄斗、西野 耕平、小迫 英尊、澤崎 達也
    • Organizer
      第94回 日本生化学会大会
    • Data Source
      KAKENHI-PUBLICLY-21H00285
  • [Presentation] 新規近接ビオチン化酵素AirIDを用いたタンパク質分解誘導剤依存的なインタラクトーム解析技術の開発2021

    • Author(s)
      山中 聡士、堀内 雄斗、西野 耕平、小迫 英尊、澤崎 達也
    • Organizer
      第94回日本生化学会
    • Data Source
      KAKENHI-PROJECT-21K15076
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    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  矢幡 一英 (40467965)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  佐倉 孝哉 (60816726)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  増本 純也 (20334914)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  吉浦 孝一郎 (00304931)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  小迫 英尊 (10291171)
    # of Collaborated Projects: 1 results
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  • 10.  川上 純 (90325639)
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  • 11.  古賀 智裕 (90537284)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  出水 庸介 (90389180)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  伊藤 拓水 (30533179)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  宮前 友策 (30610240)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  西村 健 (80500610)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  若森 晋之介 (90788134)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  鈴木 孝幸 (40451629)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  宝田 剛志 (30377428)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  戸口田 淳也 (40273502)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  松本 佳則 (80803155)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  石垣 和慶 (00790338)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  今井 祐記 (10423873)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  宮脇 義亜 (10761116)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  鍔田 武志 (80197756)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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