OHKURA Kazue 大倉一枝

Researcher Number	60094827
External Links
Affiliation (based on the past Project Information) *help	2004 – 2023: Health Sciences University of Hokkaido, Pharmaceutical Sciences, Professor., 薬学部, 教授 2003 – 2004: 北海道医療大学, 薬学部, 助教授
Review Section/Research Field	Principal Investigator Radiation science Except Principal Investigator Radiation science
Keywords	Principal Investigator 放射線 / 腫瘍 / 核医学診断 / チミジンホスホリラーゼ / 核医学 / ポジトロンCT / Tumor / Nuclear medicine / PET / Radiopharmaceuticals … More / Nucleic acid / 核酸 / stereoselective synthesis / imaging / single photon computed tomography / nucleoside / nitroimidazole / hypoxia / 低酸素細胞親和性 / 生体内分布 / 立体選択的合成 / イメージング / X線結晶構造解析 / ヌクレオシド / シングルフォトンCT / 腫瘍診断薬剤 / ニトロイミダゾール / 低酸素細胞 / SPECT / 内用放射線治療 / がん治療 / 血管新生 … More Except Principal Investigator 癌 / 放射線 / チミジンホスホリラーゼ / PET / 血管新生 / 5-フルオロウラシル / 治療効果予測 / 核医学 / Thymidine Phosphorylase / 放射性薬剤 / 分子イメージング / プリン受容体 / マクロファージ / 炎症 / 薬学 / がんのイメージング / がんイメージング / 細胞周期制御因子 / サイクリン依存性キナーゼ / CDK2 / がんのイメジング / ＰＥＴ／ＳＰＥＣＴ / IIMU / がんの核医学的分子イメージング / ５－FUプロドラッグ / 5-フルオロウラシル（5-FU） / 担癌モデル動物 / 抗がん剤Paclitaxel / プロドラッグ / 5－フルオロウラシル（5-FU) / SPECTイメージング / 核医学診断薬 / ヨウ素標識IIMU / チミジンホスホリラーゼ（TP） / グリオキサラーゼI / 放射性医薬品 / 悪性度診断 / 質的診断 / 放射性分子プローブ / グリオキサラーゼⅠ / がん / チミジンホスホリラーゼ阻害薬 / がんの悪性度評価 / F-18標識プローブ / tumor / [11C]5-FU / [11C]phogne / imaiing tracer / thymidine phosphorylase / angiogenesis factor / angiogenesis / β-アミノメタクリルアミド誘導体 / 2-^<11>C-チミジン / ^<11>C-ホスゲン / 陽電子放出画像診断薬剤 / 細胞増殖能評価薬剤 / 5-Bromo-6-[2-(oxoimidazolidinyl)methyl]uracil / 放射性標識薬剤 / 腫瘍診断薬剤 / イメージング剤 / 腫瘍 / [^<11>C]phosgene / 核医学診断薬剤 / チミジンフォスフォリラーゼ / 血管新生因子 / 自動合成 / 放射性診断薬剤 / ドキシフルリジン / カペシタビン / 抗がん剤 / イメージング / F-18標識合成 / 腫瘍イメージング / 血小板由来血管内皮細胞増殖因子 / 治療 / 臨床 / 生体分子 Less

Development of a radioactive probe targeting the cell cycle regulatory factor CDK2
- Principal Investigator
  
  Kitaura Hirotake
- Project Period (FY)
  2017 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Health Sciences University of Hokkaido
Development of a radiolabeled probe to detect a novel target, glyoxalase I, for diagnosing characteristics of cancers
- Principal Investigator
  
  AKIZAWA Hiromichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Showa Pharmaceutical University
Prediction of response to anticancer therapy by thymidine phosphorylase imaging: pre-clinical proof of concept
- Principal Investigator
  
  Zhao Songji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Fukushima Medical University
がん悪性度診断ための新規PET用チミジンホスホリラーゼＦ18イメージング剤の開発
- Principal Investigator
  
  馮飛
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Hokkaido University
Development of 125I-labeled probe for the detection of macrophage-like cells in inflammatory lesion
- Principal Investigator
  
  Kawashima Hidekazu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Kyoto Pharmaceutical University
PD-ECDF-targeted tumor imaging: Development of production system for I-123 labeled compound
- Principal Investigator
  
  Nishijima Ken-ichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Hokkaido University
Usefulness of imaging tumor-specific enzyme expression by radiopharmaceuticals with thymidine phosphorylase inhibitory potencyPrincipal Investigator
- Principal Investigator
  
  Ohkua Kazue
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Health Sciences University of Hokkaido
Prediction of efficacy of anticancer agents by in vivo imaging of thymidine phosphorylase
- Principal Investigator
  
  AKIZAWA Hiromichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Showa Pharmaceutical University
PD-ECGF-targeted tumor imaging with new F-18 radiolabeled uracil derivatives
- Principal Investigator
  
  Nishijima Ken-ichi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Hokkaido University
Development of radioiolabeled uracil derivatives as radionuclide therapeutic agents for thymidine phosphorylase expressing tumorsPrincipal Investigator
- Principal Investigator
  
  OHKURA Kazue
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Health Sciences University of Hokkaido
低酸素領域と血管新生因子のダブルターゲティング標識薬剤によるRI治療への挑戦
- Principal Investigator
  
  久下裕司
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Hokkaido University
Molecular imaging for dynamic analysis of cancer pathological states : Toward clinical molecular imaging
- Principal Investigator
  
  KUGE Yuji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Hokkaido University
Development of a radiolabeled uracil derivative as a potential PET tracer for angiogenesis imaging.Principal Investigator
- Principal Investigator
  
  OHKURA Kazue
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Health Sciences University of Hokkaido
Development of PET radiopharmaceuticals for pyrimidine'nucleotide metabolic imagingPrincipal Investigator
- Principal Investigator
  
  OHKURA Kazue
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Health Sciences University of Hokkaido
Fundamental Studies on the Development of New Diagnostic Radio Tracers Targeting Angiogenesis Factors
- Principal Investigator
  
  SEKI Koh-ichi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Hokkaido University
Development of novel labeled nucleosides for spect imaging of tumor tissue.Principal Investigator
- Principal Investigator
  
  OHKURA Kazue
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Health Sciences University of Hokkaido

[Journal Article] Redesign of negatively charged 111In-DTPA-octreotide derivative to reduce renal radioactivity2017
- Author(s)
  Oshima N., Akizawa H., Kawashima H., Zhao S., Zhao Y., Nishijima K. I., Kitamura Y., Arano Y., Kuge Y. and Ohkura K.
- Journal Title
  
  Nuclear medicine and biology
  
  Volume: 48 Pages: 16-25
- DOI
  10.1016/j.nucmedbio.2017.01.006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09886, KAKENHI-PROJECT-15K19810, KAKENHI-PROJECT-16K10335
[Journal Article] The Thymidine Phosphorylase Imaging Agent 123I-IIMU Predicts the Efficacy of Capecitabine.2016
- Author(s)
  Kobashi N, Matsumoto H, Zhao S, Meike S, Okumura Y, Abe T, Akizawa H, Ohkura K, Nishijima K, Tamaki N, Kuge Y.
- Journal Title
  
  Journal of Nuclear Medicine
  
  Volume: 8 Issue: 8 Pages: 1276-1281
- DOI
  10.2967/jnumed.115.165811
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461782
[Journal Article] イメージングによる“がん”の治療効果予測 ―新規核医学診断薬（［123I］IIMU）の臨床研究への歩み―2015
- Author(s)
  久下　裕司，西嶋　剣一，大倉　一枝，志賀　　哲，玉木　長良
- Journal Title
  
  Isotope News
  
  Volume: 1 Pages: 16-20
- Open Access
- Data Source
  KAKENHI-PROJECT-26461782
[Journal Article] Relationship between biodistribution of a novel thymidine phosphorylase (TP) probe and TP expression levels in normal mice2015
- Author(s)
  Zhao Ｓ., Li H.,Nishijima K.,,Zhao Y., Akizawa H,,Shimizu Y., Ohkura K., Tamaki N., KugeY.
- Journal Title
  
  Anal.Nucl.Med
  
  Volume: 29 Issue: 7 Pages: 582-587
- DOI
  10.1007/s12149-015-0981-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461802
[Journal Article] Radiolabeled uracil derivative as a novel SPECT probe for thymidine phosphorylase : suppressed accumulation into tumor cells by target gene knockdown2011
- Author(s)
  Li H, Zhao S, Jin Y, Nishijima K, Akizawa H, Ohkura K, Tamaki N, Kuge Y
- Journal Title
  
  Nucl Med Commun
  
  Volume: 32 Issue: 12 Pages: 1211-1215
- DOI
  10.1097/mnm.0b013e32834b7ea7
- NAID
  120004979488
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591742, KAKENHI-PROJECT-23591811, KAKENHI-PROJECT-23591826
[Journal Article] Raiolabeled uracil derivatives as a novel SPECT probe for thymidine phosphorylase suppresses accumulation into tumor cells by target gene knockdown2011
- Author(s)
  Li H., Zhao S., Jin Y., Nishijima K., Akizawa H., Ohkura K., Tamaki N., Kuge Y
- Journal Title
  
  Nucl. Med. Commun
  
  Volume: 32 Pages: 1211-1215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591826
[Journal Article] In vitro and in vivo evaluations of a radioiodinated thymidine phosphorylase inhibitor as a tumor diagnostic agent for angiogenic enzyme imaging.2010
- Author(s)
  Akizawa H, Zhao S, Takahashi M, Nishijima K, Kuge Y, Tamaki N, Seki K, Ohkura K
- Journal Title
  
  Nucl Med Biol. 37
  
  Pages: 427-432
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390320
[Journal Article] New [^<11>C] phosgene based synthesis of [^<11>C] pyrimidines for positron emission tomography2009
- Author(s)
  Seki K., Nishijima K., Sanoki K., Kuge Y., Takahashi M., Akizawa H., Tamaki N., Wiebe LI., Ohkura K.
- Journal Title
  
  Heterocycles 77
  
  Pages: 1307-1321
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591457
[Journal Article] New [11C] phosgene based synthesis of [11C]- pyrimidines for positron emission tomography2009
- Author(s)
  Seki K., Nishijima K., Sanoki K., Kuge Y., Takahashi M., Akizawa H., Tamaki N., Wiebe LI., Ohkura K.
- Journal Title
  
  Heterocycles 77
  
  Pages: 1307-1321
- Data Source
  KAKENHI-PROJECT-20591457
[Journal Article] Synthesis of ^<11>C-labeled uracil derivative for a PET tracer targeting thymidme phosphorylase2008
- Author(s)
  M.Takahashi, K.Seki, K.Nishijima, Y.Kuge, N.Tamaki, K.Ohkura
- Journal Title
  
  Heterocycles 76(in press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591288
[Journal Article] Synthesis of ^<11>C-labeled uracil derivative for a PET tracer targeting thymidine phosphorylase2008
- Author(s)
  M. Takahashi, K. Seki, K. Nishijima, Y. Kuge, N. Tamaki, K. Ohkura
- Journal Title
  
  Heterocycles 76(in press)
- NAID
  40016208568
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591288
[Journal Article] Synthesis of 11C-labeled uracil derivative for a PET tracer targeting thymidine phosphorylase2008
- Author(s)
  M. Takahashi, K Seki, K.Nishijima, Y. Kuge, N. Tamaki, K. Ohkura
- Journal Title
  
  Heterocycles 76(in press)
- NAID
  40016208568
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591288
[Journal Article] Synthesis of ^<11>C-labeled uracil derivative for a pet tracer targeting thymidine phosphorylase.2008
- Author(s)
  Takahashi M., Seki K., Nishijima K., Kuge Y., Tamaki N., Ohkura K.
- Journal Title
  
  Heterocycles 76
  
  Pages: 237-241
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591457
[Journal Article] Synthesis of 11C-labeled uracil derivative for a pet tracer targeting thymidine phosphorylase2008
- Author(s)
  Takahashi M., Seki K., Nishijima K., Kuge Y., Tamaki N., Ohkura K.
- Journal Title
  
  Hetero- cycles 76
  
  Pages: 237-241
- Data Source
  KAKENHI-PROJECT-20591457
[Journal Article] A novel and efficient synthesis of [2-^<11>C]5-fluorouracil for prognosis of cancer chemotherapy2007
- Author(s)
  K. Seki, K. Nishijima, Y. Kuge, N. Tamaki, L. I. Wiebe, K. Ohkura
- Journal Title
  
  J. Pharm. Pharm. Sci 10
  
  Pages: 210-214
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591288
[Journal Article] A novel and efficient synthesis of [2-^<11>C]5-fluorouracil for prognosis of cancer chemotherapy2007
- Author(s)
  K.Seki, K.Nishijima, Y.Kuge, N.Tamaki, L.I.Wiebe, K.Ohkura
- Journal Title
  
  J. Pharm. Pharm. Sci. 10
  
  Pages: 210-214
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] A novel and efficient synthesis of [2-^<11>C]5-fluorouracil for prognos is of cancer chemotherapy2007
- Author(s)
  K.Seki, K.Nishijima, Y.Kuge, N.Tamaki, L.I.Wiebe, K.Ohkura
- Journal Title
  
  J. Pharm. Pharm. Sci 10
  
  Pages: 210-214
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591288
[Journal Article] A novel and efficient synthesis of [2-11C]5-fluorouracil for prognosis of cancer chemotherapy2007
- Author(s)
  K. Seki, K. NIshijima, Y. Kuge, N. Tamaki, L. Wiebe, K. Ohkura
- Journal Title
  
  J Pharm Pharmaceut Sci 10
  
  Pages: 212-216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591288
[Journal Article] A new convenient method for the synthesis of [2-^<11>C]thymine utilizing [^<11>C]phosgene2007
- Author(s)
  Kazue Ohkura, Koh-ichi Seki, et al.
- Journal Title
  
  J. Pharm. Pharm. Sci. 10 (2)
  
  Pages: 181-185
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] A novel and efficient synthesis of [2-^<11>C]5-fluorouracil for prognosis of cancer chemotherapy2007
- Author(s)
  Koh-ichi Seki^<1, *>, Ken-ichi Nishijima^2, Yuji Kuge^3, Nagara Tamaki^3, Leonard I. Wiebe^4, Kazue Ohkura^<2, *>
- Journal Title
  
  J. Pharm. Pharm. Sci. 10 (2)
  
  Pages: 210-214
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] Synthesis and evaluation of radioiodinated cyclooxygenase-2 inhibitors as potential SPECT tracers for cyclooxygenase-2 expression2006
- Author(s)
  Y.Kuge, Y.Katada, K.Ohkura et al.
- Journal Title
  
  Nucl.Med.Biol. 33
  
  Pages: 21-27
- Data Source
  KAKENHI-PROJECT-17591288
[Journal Article] Synthesis and evaluation of radioiodinated cyclooxygenase-2 inhibitors as potential SPECT tracers for cyclooxygenas-2 expression2006
- Author(s)
  Y. Kuge, Y. Katada, S. Shimonaka, T. Temma, H. Kimura, Y. Kiyono, C. Yokota, K. Minematsu, K. Seki, N. Tamaki, K. Ohkura, H. Saji
- Journal Title
  
  Nuclear Medicine and Biology 33
  
  Pages: 21-27
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591288
[Journal Article] Synthesis and evaluation of radioiodinated cyclooxygenase-2 inhibit ors as potential SPECT tracers for cyclooxygenas-2 expression2006
- Author(s)
  Y.Kuge, Y.Katada, S.Shimonaka, T.Temma, H.Kimura, Y.Kiyono, C.Yokota, K.Minematsu, K.Seki, N.Tamaki, K.Ohkura H.Saji
- Journal Title
  
  Nuclear Medicine and Biology 33
  
  Pages: 21-27
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591288
[Journal Article] [^<11>C]ホスゲンを用いた核酸系PET薬剤の合成法の開発2006
- Author(s)
  関興一, 西嶋剣一, 大倉一枝
- Journal Title
  
  放射線生物研究、 41・4
  
  Pages: 387-398
- NAID
  40015265465
- Data Source
  KAKENHI-PROJECT-17591288
[Journal Article] A new convenient method for the synthesis of [2-^<11>C]thymine utilizing [^<11>C]phosgene2006
- Author(s)
  K.Ohkura, K.Nishijima, K.Sanoki, Y.Kuge, N.Tamaki, Koh-ichi Seki
- Journal Title
  
  Tetrahedron Lett. 2006
  
  Pages: 5321-5323
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] A new convenient method for the synthesis of [2-^<11>C]thymineuti lizing [^<11>C]phosgene2006
- Author(s)
  K.Ohkura, K.Nishijima, K.Sanoki, Y.Kuge, N.Tamaki, K.Seki
- Journal Title
  
  Tetrahedron Lett 47
  
  Pages: 5321-5323
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591288
[Journal Article] A new convenient method for the synthesis of [2-^<11>C]thymine utilizing [~<11>C]phosgene2006
- Author(s)
  Kazue Ohkura, et al.
- Journal Title
  
  Tetrahedron Lett. 47
  
  Pages: 5321-5323
- Data Source
  KAKENHI-PROJECT-17591288
[Journal Article] A new convenient method for the synthesis of [2-^<11>C]thymine utilizing [^<11>C]phosgene2006
- Author(s)
  Kazue Ohkura, Koh-ichi Seki, et al.
- Journal Title
  
  Tetrahedron Lett. 2006
  
  Pages: 5321-5323
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] [^<11>C]ホスゲンを用いた核酸系PET薬剤の合成法の開発2006
- Author(s)
  関興一, 西嶋剣一, 大倉一枝
- Journal Title
  
  放射線生物研究 41・4
  
  Pages: 387-398
- NAID
  40015265465
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] Synthesis of N1, N3-free pyrimidine bridged polycyclic compounds via photo-DIELS- ALDER reaction of N,N-diacetyl 5-fluorouracil with naphthalenes2006
- Author(s)
  Kazue Ohkura, Koh-ichi Seki, et al.
- Journal Title
  
  Heterocycles 69
  
  Pages: 515-520
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] Synthesis and evaluation of radioiodinated cyclooxygenase-2 inhibitors as potential SPECT tracers for cyclooxygenas-2 expression2006
- Author(s)
  Yuji Kuge, Yumiko Katada, Sayaka Shimonaka, Takashi Temma, Hiroyuki Kimura, Yasushi Kiyono, Chiaki Yokota, Kazuo Minematsu4, Koh-ichi Seki5, Nagara Tamaki6, Kazue Ohkura7, Hideo Saji
- Journal Title
  
  Nuclear Medicine and Biology 3 (1)
  
  Pages: 21-27
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] Synthesis of N1,N3-free pyrimidine bridged polycyclic compounds via photo-DIELS-ALDER reaction of N, N-diacetyl 5-fluorouracil with naphthalenes, Heterocycles2006
- Author(s)
  Kazue Ohkura, Tetsuya Ishihara, James M. Diakur, Koh-ichi Seki
- Journal Title
  
  Heterocycles 69
  
  Pages: 515-520
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] Synthesis of N1, N3-free pyrimidine bridged polycyclic compounds via photo-DIELS- ALDER reaction of N,N-diacetyl 5-fluorouracil with naphthalenes2006
- Author(s)
  K.Ohkura, T.Ishihara, J.M.Diakur, K.Seki
- Journal Title
  
  Heterocycles 69
  
  Pages: 515-520
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] A new convenient method for the synthesis of[2-^<11>C]thymine utilizing[^<11>C]phosgene2006
- Author(s)
  K. Ohkura, K. Nishijima, K. Sanoki, Y. Kuge, N. Tamaki, K. Seki
- Journal Title
  
  Tetrahedron Letters 47
  
  Pages: 5321-5323
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591288
[Journal Article] A new convenient method for the synthesis of [2-11C]thymine utilizing [11C]phosgene2006
- Author(s)
  Kazue Ohkura, Ken-ichi Nishijima, Kimihito Sanoki, Yuji Kuge, Nagara Tamaki, Koh-ichi Seki
- Journal Title
  
  Tetrahedron Lett.
  
  Pages: 5321-5323
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] (2S)-2-[1-(2,4-Difluoro-5-iodophenyl)-2-deoxy-β-D-ribofuranos-5-yl]-8-methyl-4H-1,3,2,benzodioxaphosphole 2-oxide.2004
- Author(s)
  K.Ohkura, W.Y.Sun, K.Seki, E.E.Knaus, L.I.Wiebe
- Journal Title
  
  Acta Cryst., C 60
  
  Pages: 789-791
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591297
[Journal Article] (2S)-2-[1-(2,4-Difluoro-5-iodophenyl)-2-deoxy-[3-D-ribofuranos-5-yl]-8-methyl-4H-1,3,2- benzodioxaphosphole-2-oxide2004
- Author(s)
  K.Ohkura, W.Y.Sun, K.Seki, E.E.Knaus, L.I.Wiebe
- Journal Title
  
  Acta Cryst C60
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591297
[Journal Article] Preparation and Pre-clinical Evaluation of High Specific Activity S-(-)[^<11>C]CGP-12177, a Radioligand for β-Adrenoreceptors2004
- Author(s)
  K.Nishijima, Y.Kuge, N.Motoki, K.Seki, K.Ohkura, E.Tsukamoto, K.Morita, N.Tamaki
- Journal Title
  
  Nuclear Medicine Communications 25
  
  Pages: 845-849
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] (2S)-2-[1-(2,4-Difluoro-5-iodophenyl)-2-deoxy-β-D-ribofuranos-5-yl]-8-methyl-4H-1,3,2-benzodioxaphosphole 2-oxide.2004
- Author(s)
  K.Ohkura, W.Y.Sun, K.Seki, E.E.Knaus, L.I.Wiebe
- Journal Title
  
  Acta Cryst., C 60
  
  Pages: 789-791
- Data Source
  KAKENHI-PROJECT-15591297
[Journal Article] (2S)-2[1-(2,4-Difluoro-5-iodphenyl)-2-deoxy-β-D-ribofuranos-5-yloxy]-8-methyl-4H-1,3,2-benzodioxaphosphole 2-oxide2004
- Author(s)
  K.Ohkura, W.Y.Sun, K.Seki, E.E.Knaus, L.I.Wiebe
- Journal Title
  
  Acta Crystallographica, Section C : Crystal Structure Communications C60
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] Synthesis and Antiviral Activity of Novel Fluorinated 2',3'-Dideoxynucleoside2004
- Author(s)
  P.Kumar, K.Ohkura, J.Balzarini, E.De Clercq, K.Seki, L.I.Wiebe
- Journal Title
  
  Nucleosides, Nucleotides & Nucleic Acids 23
  
  Pages: 7-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591297
[Journal Article] (2S)-2[1-(2,4-Difluoro-5-iodpheny1)-2-deoxy-□-D-ribofurano s-5-yloxy]-8-methyl-4H-1,3,2-benzodioxaphosphole 2-oxide2004
- Author(s)
  Kazue Ohkura, Wei Yan Sun, Koh-ichi Seki, Edward E. Knaus, Leonard I. Wiebe
- Journal Title
  
  Acta Crystallographica, Section C : Crystal Structure Communications C60 (11)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] Preparation and Pre-clinical Evaluation of High Specific Activity S-(-)[^<11>C]CGP-12177, a Radioligand for □-Adrenoreceptors2004
- Author(s)
  Ken-ichi Nishijima, Yuji Kuge, Noriko Motoki, Koh-ichi Seki, Kazue Ohkura, Eriko Tsukamoto, Kohich Morita, Nagara Tamaki
- Journal Title
  
  Nuclear Medicine Communications 25 (8)
  
  Pages: 845849-845849
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] Synthesis and Antiviral Activity of Novel Fluorinated 2',3'-Dideoxy-nucleoside2004
- Author(s)
  P.Kumar, K.Ohkura, J.Balzarini, E.De Clercq, K.Seki, L.I.Wiebe
- Journal Title
  
  Nucleosides, Nucleotides & Nucleic Acids 23
  
  Pages: 7-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591297
[Journal Article] Synthesis of 1-β-D-(5-Deoxy-5-iodoarabinofuranosyl)-2-nitroimidazole (β-IAZA): A Novel Marker of Tissue Hypoxia2003
- Author(s)
  P.Kumar, K.Ohkura, D.Beiki, L.I.Wiebe, K.Seki
- Journal Title
  
  Chem.Pharm.Bull. 51
  
  Pages: 399-403
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591297
[Journal Article] Synthesis of 1-β-D-(5-Deoxy-5-iodoaribinofuranosyl)-2-nitro-imidazole). (β-IAZA) : A Novel Marker of Tissue Hypoxoa2003
- Author(s)
  P.Kumar, K.Ohkura, D.Beiki, L.I.Wiebe, K.Seki
- Journal Title
  
  Chem.Pharm.Bull. 51
  
  Pages: 399-403
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591297
[Patent] ウラシル化合物又はその塩、これらを有効成分として含有するイメージング剤、およびこれらを有効成分として含有する腫瘍診断をするためのイメージング剤2012
- Inventor(s)
  発明者:大倉一枝、関興一、西嶋剣一、高橋正幸、久下裕司、玉木長良、趙松吉
- Industrial Property Rights Holder
  国立大学法人北海道大学学校法人東日本学園・北海道医療大学
- Industrial Property Rights Type
  特許
- Acquisition Date
  2012-01-18
- Overseas
- Data Source
  KAKENHI-PROJECT-23591826
[Patent] ウラシル化合物又はその塩、これらを有効成分として含有するイメージング剤、およびこれらを有効成分として含有する腫瘍を診断するためのイメ-ジング剤2007
- Inventor(s)
  大倉一枝, 関興一, 西嶋剣一, 高橋正幸, 久下裕司, 玉木長良, 趙松吉
- Industrial Property Rights Holder
  大鵬薬品工業株式会社学校法人東日本学園・北海道医療大学国立大学法人北海道大学
- Industrial Property Number
  2007-229002
- Filing Date
  2007-09-04
- Data Source
  KAKENHI-PROJECT-17591288
[Patent] ウラシル化合物又はその塩、これらを有効成分として含有するイメージング剤、およびこれらを有効成分として含有する腫瘍を診断するためのイメージング剤2007
- Inventor(s)
  大倉一枝, 関興一, 西嶋剣一, 高橋正幸, 久下裕司, 玉木長良, 趙松吉
- Industrial Property Rights Holder
  大鵬薬品工業株式会社学校法人東日本学園、北海道医療大学国立大学法人北海道大学
- Industrial Property Number
  2007-229002
- Filing Date
  2007-09-04
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591288
[Presentation] チミジンホスホリラーゼ標的放射性プローブ[125I]IIMUの取り込みに対する有機カチオントランスポーターの影響2018
- Author(s)
  中山賢志、宿里充穂、東川桂、尾江悟、水野雄貴、大倉一枝、久下裕司、秋澤宏行
- Organizer
  日本薬学会第１３８年会（金沢）
- Data Source
  KAKENHI-PROJECT-26461802
[Presentation] チミジンホスホリラーゼイメージングプローブによる非アルコール性脂肪肝炎の診断法の開発研究。2018
- Author(s)
  東川桂、堀口紗和子、足澤誠、小松由紀子、大倉一枝、安井博宣、武田宏司、久下裕司。
- Organizer
  第13回日本分子イメージング学会
- Data Source
  KAKENHI-PROJECT-16K10335
[Presentation] Feasibility and potentials of thymidine phosphorylase (TP) as an imaging biomarker and its nuclear medicine imaging for the diagnosis of non-alcoholic　steatohepatitis.2018
- Author(s)
  Higashikawa K, Horiguchi S, Ebita Y, Tarisawa M, Komatsu Y, Ohkura K, Yasui H, Takeda H, Kuge Y.
- Organizer
  Society of Nuclear Medicine and Molecular Imaging 2018 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10335
[Presentation] Preclinical and translational researchs novel PET and SPECT tracers: 18F-Difa and 123I-IIMU for hypoxia and thymidine phosphorylase imaging2015
- Author(s)
  Zhao S., Nishijima K., Matsumoto H., Akizawa H., Ohkura K., Tamaki N., Kuge Y.
- Organizer
  アジアオセアニア核医学・生物学会（AOCNMB 2015）
- Place of Presentation
  韓国チェジュ
- Year and Date
  2015-10-31
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461802
[Presentation] Preclinical evaluation of thymidine phosphorylase imaging probe, [123I]IIMU, A road to First-in-human clinical study2015
- Author(s)
  Nishijima K, Zhao S, Matsumoto H, Akizawa H, Ohkura K, Shiga T, Hirata K, Watanabe S, Okamoto S, Tamaki N, Kuge Y
- Organizer
  Ninth Japan-China Joint Seminar on Radiopharmaceutical Chemistry
- Place of Presentation
  放射線医学総合研究所（千葉県・稲毛市）
- Year and Date
  2015-11-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461782
[Presentation] Preparation and evaluation of [123I]IIMU for SPECT imaging of thymidine phosphorylase expression in tumors.2013
- Author(s)
  Nishijima K, Zhao S, Zhao Y, Feng F, Shimizu Y, Abo N, Akizawa H, Ohkura K, Tamaki N, and Kuge Y
- Organizer
  20th International Symposium on Radiopharmaceutical Sciences
- Place of Presentation
  ICC Jeju (Korea)
- Data Source
  KAKENHI-PROJECT-23591811
[Presentation] Preparation and evaluation of IIMU for SPECT imaging thymidine phosphorylase expression in tumors2013
- Author(s)
  Nishijima K, Zhao S, Zhao Y, Feng F, Shimizu Y, Abo N, Akizawa H, Ohkura K, Tamaki N, Kuge Y
- Organizer
  20^<th> International Synposium on Radiopharmaceutical Sciences
- Place of Presentation
  Jeju, Korea
- Data Source
  KAKENHI-PROJECT-23591826
[Presentation] チミジンホスホリラーゼイメージング剤[^<123>I]IIMUによるCapecitabineの治療効果予測2013
- Author(s)
  小橋信弥,女池俊介,奥村侑紀,阿部務,秋澤宏行,大倉一枝,西嶋剣一,趙松吉,久下裕司,松本博樹
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23591826
[Presentation] Preparation and evaluation of [123I]IIMU for SPECT imaging of thymidine phosphorylase expression in tumors.2013
- Author(s)
  Nishijima K, Zhao S, Zhao Y, Feng F, Shimizu Y, Abo N, Akizawa H, Ohkura K, Tamaki N, and Kuge Y
- Organizer
  20th International Symposium on Radiopharmaceutical Sciences
- Place of Presentation
  Jeju, Korea
- Data Source
  KAKENHI-PROJECT-23591826
[Presentation] チミジンホスホリラーゼを標的とする新規腫瘍イメージング剤^<123>I-IIMUの開発:マウス組織におけるチミジンホスホリラーゼ発現と^<123/125>I-IIMU集積との関係2012
- Author(s)
  趙松吉,李花,西嶋剣一,秋澤宏行,大倉一枝,玉木長良,久下裕司
- Organizer
  第7回分子イメージング学会学術集会
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-23591826
[Presentation] 放射性標識核酸誘導体による腫瘍の核医学診断と内用療法2012
- Author(s)
  秋澤宏行, 趙松吉, 高橋正幸, 西嶋剣一, 関興一, 玉木長良, 下裕司, 大倉一枝
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23591826
[Presentation] チミジンホスホリラーゼイメージング剤[^<123>I]5-iodo-6[(2-iminoimidazoli- dinyl)methyl]uracilの開発;タンパク結合測定と画像化の検討2012
- Author(s)
  西嶋剣一, 越田早織, 趙松吉, 秋澤宏行, 大倉一枝, 松本博樹, 志賀哲, 玉木長良, 久下裕司
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23591826
[Presentation] チミジンホスホリラーゼイメージング剤[123I]5-iodo-6-[(2-iminoimidazolidinyl)methyl]uracilの開発：タンパク結合測定と画像化の検討2012
- Author(s)
  西嶋剣一、越田早織、趙松吉、秋澤宏行、大倉一枝、松本博樹、志賀　哲、玉木長良、久下裕司
- Organizer
  日本薬学会　第132年会
- Place of Presentation
  北海道大学（札幌）
- Data Source
  KAKENHI-PROJECT-23591811
[Presentation] チミジンホスホリラーゼイメージング剤[123I]5-iodo-6-[(2-iminoimidazolidinyl)methyl]uracilの開発：血漿タンパク結合とI-123標識合成検討2011
- Author(s)
  西嶋剣一、越田早織、趙松吉、秋澤宏行、大倉一枝、松本博樹、久下裕司
- Organizer
  第11回放射性医薬品・画像診断薬研究会
- Place of Presentation
  京都テルサ（京都）
- Data Source
  KAKENHI-PROJECT-23591811
[Presentation] [^<11>C] phosgeneを用いるoxoimidazolidinylmethyluracilの合成とがんイメージングプローブへの応用2010
- Author(s)
  関興一・西嶋剣一・高橋正幸・趙松吉・向田理恵・秋澤宏行・久下裕司・玉木長良・大倉一枝
- Organizer
  日本化学会第90春季年会
- Place of Presentation
  大阪(近畿大学)
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20591457
[Presentation] A novel radiolabeled probe for molecular imaging of thymidine phosphorylase : Suppressed accumulation into tumor cells by target gene knockdown.2010
- Author(s)
  Li H, Zhao S, Jin Y, Nishijima K, Akizawa H, Ohkura K, Seki K, Tamaki N, Kuge Y
- Organizer
  2010 World Molecular Imaging Congress
- Place of Presentation
  Kyoto, Japan.
- Data Source
  KAKENHI-PROJECT-20390320
[Presentation] 放射性がん血管新生イメージングプローブの創製2010
- Author(s)
  大倉一枝, 他
- Organizer
  日本化学会第90春季年会
- Place of Presentation
  大阪(近畿大学本部キャンパス)
- Data Source
  KAKENHI-PROJECT-20390320
[Presentation] 放射性がん血管新生イメージングプローブの創製2010
- Author(s)
  大倉一枝, 他
- Organizer
  日本化学会第90春季年会
- Place of Presentation
  大阪(近畿大学本部キャンパス)
- Data Source
  KAKENHI-PROJECT-21659281
[Presentation] [11C]phosgene を用いるoxo-imidazolidinylmethyluracil の合成とがんイメージングプローブへの応用2010
- Author(s)
  関興一・西嶋剣一・高橋正幸・趙松吉・向田理恵・秋澤宏行・久下裕司・玉木長良・大倉一枝
- Organizer
  日本化学会第90春季年会
- Place of Presentation
  大阪
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20591457
[Presentation] チミジンボスホリラーゼ標的SPECT薬剤の合成2008
- Author(s)
  高橋正幸、趙松吉、西嶋剣一、久下裕司、関興一、大倉一枝
- Organizer
  日本薬学会第128年会(横浜)
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2008-03-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591288
[Presentation] チミジンホスホリラーゼ標的イメージング剤の合成とその有用性に関する基礎的検討2008
- Author(s)
  大倉一枝, 他
- Organizer
  第48回日本核医学会総会
- Place of Presentation
  千葉、幕張メッセ
- Data Source
  KAKENHI-PROJECT-20390320
[Presentation] Synthesis of a Potential SPECT Tracer for Angiogenic Enzyme Expression Graduate School of Medicine.2008
- Author(s)
  Seki K, Takahashi M, Zhao S, Nishijima K, Kuge Y, Tamaki N, Ohkura K
- Organizer
  2008 World Molecular Imaging Congress
- Place of Presentation
  Nice.
- Data Source
  KAKENHI-PROJECT-20390320
[Presentation] Development of a novel and general synthesis of [2-^<11>C]pyrimidine2007
- Author(s)
  K. Seki, K. Nishijima, K. Sanoki, Y. Kuge, N. Tamaki, K. Ohkura
- Organizer
  JCSRC 2007 Seventh Japan-China Joint Seminar on Radiopharmaceutical Chemistry
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-17591288
[Presentation] Development of a novel and general synthesis of 2-^<11>C]pyrimidine2007
- Author(s)
  K. SeKi, K. Nishijima, K. SanoKi, Y. Kuge, N. Iamaki, K. Ohkura
- Organizer
  JCSRC 2007 seventh Japan-China Joint Seminar on Radiopharmaceutical Chemistry
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591288
[Presentation] Development of a novel and general synthesis of [2-^<11>C]pyrimidine2007
- Author(s)
  K.Seki, K.Nishijima, K.Sanoki, Y.Kuge, N.Tamaki, K.Ohkura
- Organizer
  JCSRC 2007 Seventh Japan China Joint Seminar on Radiopharmaceutical Chemistry
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591288
[Presentation] Preclinical evaluation of thymidine phosphorylase imaging probe, 123I-IIMU for the First-in-Human clinical trials.
- Author(s)
  Nishijima K, Zhao S, Feng F, Shimizu Y, Akizawa H, Ohkura K, Kobashi N. Abe T, Matsumoto H, Tamaki N, Kuge Y
- Organizer
  The 12th International Symposium for Future Drug Discovery and Medical Care, Perspectives of Molecular and Target Therapy
- Place of Presentation
  Sapporo
- Year and Date
  2014-09-04 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-26461802

1. KUGE Yuji (70321958)

# of Collaborated Projects: 11 results

# of Collaborated Products: 25 results
2. AKIZAWA Hiromichi (90311795)

# of Collaborated Projects: 6 results

# of Collaborated Products: 15 results
3. SEKI KohーIchi (60094835)

# of Collaborated Projects: 5 results

# of Collaborated Products: 46 results
4. Nishijima Ken-ichi (60364254)

# of Collaborated Projects: 5 results

# of Collaborated Products: 27 results
5. TAMAKI Nagara (30171888)

# of Collaborated Projects: 5 results

# of Collaborated Products: 28 results
6. ZHAO Songji (80374239)

# of Collaborated Projects: 5 results

# of Collaborated Products: 9 results
7. 東川桂 (10756878)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
8. Kawashima Hidekazu (70359438)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. Oshima Nobuhiro (80508648)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 志水陽一 (90634212)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. Kitaura Hirotake (10281817)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 相田一樹 (80456839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 馮飛 (60374196)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 宿里充穗 (20525571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 尾江悟 (90756107)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 志賀哲 (80374495)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 北川善政 (00224957)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 水野雄貴 (90805194)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. KITAMURA Yoji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OHKURA Kazue 大倉 一枝

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Usefulness of imaging tumor-specific enzyme expression by radiopharmaceuticals with thymidine phosphorylase inhibitory potencyPrincipal Investigator

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Development of radioiolabeled uracil derivatives as radionuclide therapeutic agents for thymidine phosphorylase expressing tumorsPrincipal Investigator

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Development of a radiolabeled uracil derivative as a potential PET tracer for angiogenesis imaging.Principal Investigator

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Development of PET radiopharmaceuticals for pyrimidine'nucleotide metabolic imagingPrincipal Investigator

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OHKURA Kazue 大倉一枝