TAKAISHI Hironari 高石官成

… Alternative Names

高石官成タカイシヒロナリ

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Researcher Number	60236180
Other IDs
Affiliation (based on the past Project Information) *help	2009 – 2010: Keio University, 医学部, 講師 2007 – 2008: Keio University, 医学部, 助教 2003 – 2006: 慶應義塾大学, 医学部, 助手 1997 – 1998: 慶應義塾大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Orthopaedic surgery Except Principal Investigator Orthopaedic surgery
Keywords	Principal Investigator 間葉系 / カルシウムシグナル / 破骨細胞 / トランスレーショナルリサーチ / 発現制御 / 細胞・組織 / 再生医学 / 外科 / 脊索 / 転写領域 … More / 椎間板 / IIコラーゲン / 転写因子 / マトリックス / 軟骨細胞 / エンハンサー / II型コラーゲン … More Except Principal Investigator 椎間板 / degeneration / intervertebral disc / TIMP-3 / 腰痛 / low back pain / bioactive molecules / cell and tissue / 表面マーカー / 加齢変性 / 髄核細胞 / 脊索 / マイクロアレイ / 再生医療 / CD24 / 退行変性 / 生体分子 / 細胞・組織 / collagen / Aggrecan / matrix / annulus fibrosus / nucleus pulposus / プロテオグリカン / 組織培養 / コラーゲン / アグリカン / 細胞外基質 / 変性 / 線維輪 / 髄核 / 血管進入 / 血管侵入 / 関節軟骨 / 血管新生因子 / 神経反発因子 / 変形性関節症 / Smad / 骨粗鬆症 / 椎間板変性 / MAPK / TGF-β / 2型コラーゲン / 軟骨 / エストロゲン Less

硬組織の形成と破壊を制御するストア作動性カルシウム流入機構の解明Principal Investigator
- Principal Investigator
  
  高石官成
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
Link between estrogen and TGF-beta signaling in intervertebral disc metabolism - possible therapeutic target for degenerative disc disease
- Principal Investigator
  
  CHIBA Kazuhiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
The regulation of vascularity by Semaphorin-3A in the osteo-cartilaginous tissues
- Principal Investigator
  
  FUJITA Yoshinari
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
A Role of MMP-13 in Inflammatory Bone and Cartilage DestructionPrincipal Investigator
- Principal Investigator
  
  TAKAISHI Hironari
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
Molecular and cellular approaches to the treatment of degenerative lumbar disc disease
- Principal Investigator
  
  CHIBA Kazuhiro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  KEIO UNIVERSITY
The basic research of the mechanism and the treatment for intervertebral disc degeneration.
- Principal Investigator
  
  CHIBA Kazuhiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
軟骨細胞分化過程におけるII型コラーゲン遺伝子転写調節領域の解析Principal Investigator
- Principal Investigator
  
  高石官成
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University

All 2010 2009 2008 2007 2004

All Journal Article Presentation

[Journal Article] GRIP1 enhances estrogen receptor alpha-dependent extracellular matrix gene expression in chondrogenic cells2010
- Author(s)
  Kato M, Takaishi H, Yoda M, Tohmonda T, Takito J, Fujita N, Hosogane N, Horiuchi K, Kimura T, Okada Y, Saito T, Kawaguchi H, Kikuchi T, Matsumoto M, Toyama Y, Chiba K
- Journal Title
  
  Osteoarthritis Cartilage. (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591961
[Journal Article] Accelerated cartilage resorption by chondroclasts during bone fracture healing in osteoprotegerin-deficient mice2010
- Author(s)
  Ota N, Takaishi H, Kosaki N, Takito J, Yoda M, Tohmonda T, Kimura T, Okada Y, Yasuda H, Kawaguchi H, Matsumoto M, Chiba K, Ikegami H, Toyama Y
- Journal Title
  
  Endocrinology 150
  
  Pages: 4823-4823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591961
[Journal Article] Inhibition of STAT1 accelerates bone fracture healing2010
- Author(s)
  Tajima K, Takaishi H, Takito J, Tohmonda T, Yoda M, Ota N, Kosaki N, Matsumoto M, Ikegami H, Nakamura T, Kimura T, Okada Y, Horiuchi K, Chiba K, Toyama Y
- Journal Title
  
  J Orthop Res. (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591961
[Journal Article] Receptor activator of NF-kappaB(RANK)ligand induces ectodomain shedding of RANK in murine RAW264.7 macrophages2010
- Author(s)
  Hakozaki A, Yoda M, Tohmonda T, Furukawa M, Hikata T, Uchikawa S, Takaishi H, Matsumoto M, Chiba K, Horiuchi K, Toyama Y
- Journal Title
  
  J Immunol. 184
  
  Pages: 2442-2448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591961
[Journal Article] 1-alpha, 25-dihydroxy vitamin D3 inhibits osteoclastogenesis through IFN-beta-dependent NFATc1 suppression2009
- Author(s)
  Sakai S, Takaishi H, et al., 13名中2番目
- Journal Title
  
  J Bone Miner Metab (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591764
[Journal Article] MMP-13 plays a role in keratinocyte migration, angiogenesis, and contraction in mouse skin wound healing2009
- Author(s)
  Hattori N, Mochizuki S, Kishi K, Nakajima T, Takaishi H, D'Armiento J, Okada Y
- Journal Title
  
  Am J Pathol. 175
  
  Pages: 583-546
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591961
[Journal Article] IL-27 abrogates receptor activator of NF-kappa B ligand-mediated osteoclastogenesis of human granulocyte-macrophage colony-forming unit cells through STAT1-dependent inhibition of c-Fos2009
- Author(s)
  Ota N, Takaishi H, Kosaki N, Takito J, Yoda M, Tohmonda T, Kimura T, Okada Y, Yasuda H, Kawaguchi H, Matsumoto M, Furukawa M, Takaishi H, Takito J, Yoda M, Sakai S, Hikata T, Hakozaki A, Uchikawa S, Matsumoto M, Chiba K, Kimura T, Okada Y, Matsuo K, Yoshida H, Toyama YK, Ikegami H, Toyama Y
- Journal Title
  
  Endocrinology 183
  
  Pages: 2397-2406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591961
[Journal Article] PIAS3 negatively regulates RANKL-mediated osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblasts2009
- Author(s)
  Hikata T, Takaishi H, et. al., 14名
- Journal Title
  
  Blood 113(10)
  
  Pages: 2202-2212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591764
[Journal Article] IL-27 Abrogates RANKL-mediated Osteoclastogenesis of Human Granulocyte-Macrophage CFU Cells through STAT1-dependent Inhibition of c-Fos2009
- Author(s)
  Furukawa M, Takaishi H, et al., 11名中2番目
- Journal Title
  
  J Immunol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591764
[Journal Article] Fra-1/AP-1 impairs inflammatory responses and chondrogenesis in fracture healing2009
- Author(s)
  Yamaguchi T, Takada Y, Maruyama K, Shimoda K, Arai Y, Nango N, Kosaki N, Takaishi H, Toyama Y, Matsuo K
- Journal Title
  
  J Bone Miner Res. 24
  
  Pages: 2056-2065
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591961
[Journal Article] Ectodomain shedding of FLT3 ligand is mediated by TNF-alpha converting enzyme2009
- Author(s)
  Horiuchi K, Morioka H, Takaishi H, Akiyama H, Blobel CP, Toyama Y.
- Journal Title
  
  J Immunol. 182
  
  Pages: 7408-7418
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591961
[Journal Article] PIAS3 negatively regulates RANKL-mediated osteoclastogenesis directly in osteoclast precursors and indirectlyvia osteoblasts.2009
- Author(s)
  Hikata T, Takaishi H, et . al., 14名中2番目
- Journal Title
  
  Blood 113 (10)
  
  Pages: 2202-2212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591764
[Journal Article] Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF2009
- Author(s)
  Horiuchi K, Kimura T, Miyamoto T, Miyamoto K, Akiyama H, Takaishi H, Morioka H, Nakamura T, Okada Y, Blobel CP, Toyama Y
- Journal Title
  
  J Immunol. 182
  
  Pages: 2093-2101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591961
[Journal Article] Surgical treatment of intramedullary spinal cord tumors : prognosis and complications2008
- Author(s)
  Nakamura M, Ishii K, Watanabe K, Tsuji T, Takaishi H, Matsumoto M, Toyama Y, Chiba K
- Journal Title
  
  Spinal Cord 46巻
  
  Pages: 282-286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591734
[Journal Article] Surgical treatment of intramedullary spinal cord tumors : prognosis and complications.2008
- Author(s)
  Nakamura M, Ishii K, Watanabe K, Tsuji T, Takaishi H, Matsumoto M, Toyama Y, Chiba K.
- Journal Title
  
  Spinal Cord. 46
  
  Pages: 282-286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591734
[Journal Article] Joint diseases and matrix metalloproteinases : a role for MMP-13.2008
- Author(s)
  Takaishi H, Kimura T, Dalal S, Okada Y, D'Armiento J.
- Journal Title
  
  Curr Pharm Biotechnol. 9
  
  Pages: 47-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591764
[Journal Article] Joint disease and matrix metalloproteinases:a role for MMP-132008
- Author(s)
  Takaishi H, Kimura T, Dalal S, Okada Y, D' Amiento J.
- Journal Title
  
  Curr Pham Biotechnol 9(1)
  
  Pages: 47-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591764
[Journal Article] Joint diseases and matrix metalloproteinases : a role for MMP-132008
- Author(s)
  Takaishi H, Kimura T, Dalal S, Okada Y, D'Armiento J. 5名
- Journal Title
  
  Curr Pharm Biotechnol 9
  
  Pages: 47-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591764
[Journal Article] Cutting edge:TNF-alpha-converting enzyme(TACE/ADAM17)inactivation in mouse my eloid cells prevents lethality from endotoxin shock2007
- Author(s)
  Horiuchi K, Kimura T, Miyamoto T, Takaishi H, Okada Y, Toyama Y., Blobel CP.
- Journal Title
  
  J Immunol 179(5)
  
  Pages: 2686-2689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591764
[Journal Article] Administration of cyclooxygenase-2 inhibitor reduces joint inflammation excerbates osteopenia in IL-1 alpha transgenic mice due to GM-CSF overproduction2007
- Author(s)
  Niki Y, Takaishi H, Takito J, Miyamoto T, Kosaki N, Matsumoto H, Toyama Y, Tada N.
- Journal Title
  
  J Immunol 179(1)
  
  Pages: 639-646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591764
[Journal Article] Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification2007
- Author(s)
  Morita K, Miyamoto T, Fujita N, Kubota Y, Ito K, Takubo K, Miyamoto K, Ninomiya K, Suzuki T, Iwasaki R, Yai M, Takaishi H, Toyama Y, Suda T.
- Journal Title
  
  J Exp Med 204(7)
  
  Pages: 1613-1623
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591764
[Journal Article] Impaired bone fracture healing in matrix metalloproteinase-13 deficient mice2007
- Author(s)
  osaki N, Takaishi H, et al., 12名
- Journal Title
  
  Biochem Biophys Res Commun 354
  
  Pages: 846-851
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591764
[Journal Article] Administration of cyclooxygenase-2 inhibitor reduces joint inflammation but exacerbates osteopenia in IL-1 alpha transgenic mice due to GM-CSF overproduction2007
- Author(s)
  Niki Y, Takaishi H, et al., 8名
- Journal Title
  
  J Immunol 179
  
  Pages: 639-646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591764
[Journal Article] Cell surface colony-stimulating factor 1 can be cleaved by TNF-alpha converting enzyme or endocytosed in a clathrin-dependent manner2007
- Author(s)
  Horiuchi K, Miyamoto T, Takaishi H, Hakozaki A, Kosaki N, Miyauchi Y, Furukawa M, Takito J, Kaneko H, Matsuzaki K, Morioka H, Blobel CP, Toyama Y.
- Journal Title
  
  J Immunol 179(10)
  
  Pages: 6715-6724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591764
[Journal Article] Impaired bone frachture healing in matrix metalloproteinase-13 deficient mice2007
- Author(s)
  Kosaki N, Takaishi H, Kamekura S, Kimura T, Okada Y, Minqi L, Amizuka N, Chung UI, Nakamura K, Kawaguchi H, Toyama Y, D' Armiento J.
- Journal Title
  
  Biochem Biophys Res Commun 354(4)
  
  Pages: 846-851
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591764
[Journal Article] Development of a New Zealand White rabbit model of pseudoarthrosis repair and evaluation of the potential role of OP-1 to overcome pseudarthrosis.2004
- Author(s)
  Ogawa Y., Chiba_K., Matsumoto M., Nakamura M., Takaishi H., Hirabayashi H., Hirabayashi K., Toyama Y
- Journal Title
  
  J Neurosurg Spine. 2
  
  Pages: 168-174
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591601
[Journal Article] Long-term results(minimal five years) of expansive open-door laminoplasty for ossification of the posterior longitudinal ligament of the cervical spine.2004
- Author(s)
  Ogawa Y., Chiba K., Matsumoto M., Nakamura M., Takaishi H., Hirabayashi H., Hirabayashi K., Toyama Y.
- Journal Title
  
  J Neurosurg Spine 2
  
  Pages: 168-174
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591601
[Presentation] A Possible Link between Estrogen and TGF-β Signaling in Intervertebral Disc Metabolism : Estrogen receptor α-Dependent Regulation of Type II Collagen Gene Expression in Chondrocytic Cells2009
- Author(s)
  加藤雅敬, 高石官成, 千葉一裕
- Organizer
  55^<th> Annual Meeting of Orthopaedic Researh Society
- Place of Presentation
  アメリカ(ラスベガス)
- Year and Date
  2009-02-22
- Data Source
  KAKENHI-PROJECT-19591734
[Presentation] Estorgen Regulates Type II Collagen Gene Expression via ERalpha-dependent Genomic Actions in Rat Intervertebral Disc Cells2008
- Author(s)
  加藤雅敬, 高石官成, 千葉一裕
- Organizer
  第35回国際腰椎学会
- Place of Presentation
  ジュネーブ
- Year and Date
  2008-05-26
- Data Source
  KAKENHI-PROJECT-19591734
[Presentation] 卵巣摘出ラットにおける椎間板変性機序の解析-第2報 : ERαを介しかII型コラーゲン遺伝子の転写制御について-2008
- Author(s)
  加藤雅敬, 高石官成, 千葉一裕
- Organizer
  第23回日本整形外科学会基礎学術集会
- Place of Presentation
  京都
- Year and Date
  2008-10-24
- Data Source
  KAKENHI-PROJECT-19591734
[Presentation] Type II Collagen Gene Expression of Intervertebral Disc in Ovariectomized Rats.2008
- Author(s)
  M. Kato, H. Takaishi, K. Chiba
- Organizer
  54^Annual Meeting of Orthopaedic Researh Society.
- Place of Presentation
  San Francisco,CA
- Year and Date
  2008-03-03
- Data Source
  KAKENHI-PROJECT-19591734
[Presentation] ラット卵巣摘出モデルにおいて椎間板変性は経時的に進行する2007
- Author(s)
  加藤雅敬, 高石官成, 千葉一裕
- Organizer
  第25回日本骨代謝学会
- Place of Presentation
  大阪
- Year and Date
  2007-07-20
- Data Source
  KAKENHI-PROJECT-19591734
[Presentation] ラット卵巣摘出モデルにおいて椎間板変性経時的に進行する2007
- Author(s)
  加藤雅敬, 高石官成, 千葉一裕
- Organizer
  第22回日本整形外科学会に基礎学術集会
- Place of Presentation
  浜松
- Year and Date
  2007-10-26
- Data Source
  KAKENHI-PROJECT-19591734
[Presentation] Degeneration of Intervertebral Disc in Ovariectomized Rats.2007
- Author(s)
  M. Kato, H. Takaishi, K. Chiba
- Organizer
  29^The American Society for Bone and Mineral Research.
- Place of Presentation
  Honolulu,HI
- Year and Date
  2007-09-18
- Data Source
  KAKENHI-PROJECT-19591734
[Presentation] Type II Collagen Gene Expression of Intervertebral Disc in Ovariectomized Rats.2007
- Author(s)
  M. Kato, H. Takaishi, K. Chiba
- Organizer
  6^Combined Meeting of Orthopaedic Research Society.
- Place of Presentation
  Honolulu,HI
- Year and Date
  2007-10-23
- Data Source
  KAKENHI-PROJECT-19591734

1. CHIBA Kazuhiro (80179952)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
2. TSUJI Takashi (60296639)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. FUJITA Yoshinari (10296642)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KIMURA Tokuhiro (40445200)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. OKUBO Masashi (30445225)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TOYAMA Yoshiaki (40129549)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. HORIUCHI Keisuke (30327564)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. HAKOZAKI Akihiro (10365299)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 三尾太

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TAKAISHI Hironari 高石 官成

高石 官成 タカイシ ヒロナリ

Research Projects

Research Products

Co-Researchers

硬組織の形成と破壊を制御するストア作動性カルシウム流入機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Link between estrogen and TGF-beta signaling in intervertebral disc metabolism - possible therapeutic target for degenerative disc disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The regulation of vascularity by Semaphorin-3A in the osteo-cartilaginous tissues

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A Role of MMP-13 in Inflammatory Bone and Cartilage DestructionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular and cellular approaches to the treatment of degenerative lumbar disc disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The basic research of the mechanism and the treatment for intervertebral disc degeneration.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

軟骨細胞分化過程におけるII型コラーゲン遺伝子 転写調節領域の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] GRIP1 enhances estrogen receptor alpha-dependent extracellular matrix gene expression in chondrogenic cells2010

Author(s)

Journal Title

Data Source

[Journal Article] Accelerated cartilage resorption by chondroclasts during bone fracture healing in osteoprotegerin-deficient mice2010

Author(s)

Journal Title

Data Source

[Journal Article] Inhibition of STAT1 accelerates bone fracture healing2010

Author(s)

Journal Title

Data Source

[Journal Article] Receptor activator of NF-kappaB(RANK)ligand induces ectodomain shedding of RANK in murine RAW264.7 macrophages2010

Author(s)

Journal Title

Data Source

[Journal Article] 1-alpha, 25-dihydroxy vitamin D3 inhibits osteoclastogenesis through IFN-beta-dependent NFATc1 suppression2009

Author(s)

Journal Title

Data Source

[Journal Article] MMP-13 plays a role in keratinocyte migration, angiogenesis, and contraction in mouse skin wound healing2009

Author(s)

Journal Title

Data Source

[Journal Article] IL-27 abrogates receptor activator of NF-kappa B ligand-mediated osteoclastogenesis of human granulocyte-macrophage colony-forming unit cells through STAT1-dependent inhibition of c-Fos2009

Author(s)

Journal Title

Data Source

[Journal Article] PIAS3 negatively regulates RANKL-mediated osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblasts2009

Author(s)

Journal Title

Data Source

[Journal Article] IL-27 Abrogates RANKL-mediated Osteoclastogenesis of Human Granulocyte-Macrophage CFU Cells through STAT1-dependent Inhibition of c-Fos2009

TAKAISHI Hironari 高石官成

高石官成タカイシヒロナリ

軟骨細胞分化過程におけるII型コラーゲン遺伝子転写調節領域の解析Principal Investigator