Shibanuma Motoko 柴沼質子

… Alternative Names

柴沼質子シバヌマモトコ

SHIBANUMA Motoko 柴沼質子

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Researcher Number	60245876
Other IDs
Affiliation (Current)	2025: 昭和医科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 昭和大学, 薬学部, 教授 2008 – 2017: Showa University, 薬学部, 教授 2007 – 2008: Showa University, 薬学部, 准教授 1995 – 2006: 昭和大学, 薬学部, 助教授 2000: 昭和大, 薬学部, 助教授 1993 – 1994: 昭和大学, 薬学部, 助手 1993: 昭和大学, 薬学部・微生物薬品化学教室, 助手
Review Section/Research Field	Principal Investigator Biological pharmacy / Biological Sciences / Cell biology / Basic Section 48030:Pharmacology-related / Pathological medical chemistry Except Principal Investigator Biological pharmacy / Basic Section 49010:Pathological biochemistry-related / Pathological medical chemistry / Biological Sciences / Drug development chemistry / Biological pharmacy
Keywords	Principal Investigator Hic-5 / ミトコンドリア / c-fos / 活性酸素 / focal adhesion / HIC-5 / HMGA2 / MMP9 / TGFβ / 接着斑 … More / 核移行 / パキシリン / 細胞分化 / 代謝ストレス応答 / 臓器横断的癌治療薬 / ミトコンドリアストレス応答機構 / 呼吸鎖 / AMPK / ミトコンドリアストレス応答 / Smad3 / oxidative stress / paxillin / c-foc / 過酸化水素 / NES / Sp1 / FAK / expression vectors / Zn finger protein / differentiation / Alu配列 / Znフィンガー / 細胞接着斑 / Zn-フィンガー / E2F1 / ミトコンドリア呼吸鎖活性 / 肝細胞がん / ミトコンドリアDNA変異 / ミトコンドリアDNA / プロテインキチーゼC / チオレドキシン / 膜電位 / CHOP-10 / CREB / matrix metalloproteinase / 遺伝子発現 / マトリックスメタロプロテアーゼ / サイクリンD1 / 足場依存性増殖 / cyclin D1 / p21 / RhoA / 転写 / 細胞接着 / G-蛋白質 / 遺伝子発現制御 / ヘテロクロマチン / テロメア / DNA結合性 / HIC-5遺伝子 / 細胞膜蛋白 / アミノ酸配列 / 細胞内標的蛋白質 / 増殖制御 / cDNA / TGF-beta … More Except Principal Investigator Hic-5 / c-fos / ミトコンドリア / 活性酸素 / 核移行 / パキシリン / 細胞接着斑 / focal adhesion / nuclear lozalization / paxillin / 酸化ストレス / 接着斑 / TGF-beta / TGFβ / レポーター / p16 / Zn-フィンガー / cDNA / 過酸化水素 / Integrin β4 / 転移抑制 / 細胞接着 / Rac1 / integrin beta4 / p21cip1 / 電子伝達系 / ミトコンドリア電子伝達系 / エネルギー代謝 / NAD+ / サイクリン依存性キナーゼ阻害因子p21Cip1 / ミトコンドリア呼吸鎖 / 分子標的薬 / 皮膚 / 炎症性疾患 / PKC / 炎症 / 分子標的治療 / NOX4 / MMP-9 / NADPH oxidase 4 / 活性酸素種 / MMP9 / mitochondria / NADPH oxidase / reactive oxygen species / TGFb / 間葉系遺伝子 / EMT / プロテオーム / DNAアレイ / Nox4 / TGF-β / NADPHオキシダーゼ / 上皮細胞 / p38 / MMP / 核マトリクス / LIM蛋白質 / レドクス / Hic-5蛋白質 / 転写 / PTP-PEST / gene expression / Zn-finger / Senescence / フオリスタチン / TGF-β1 / 遺伝子発現 / Znフィンガー / 細胞老化 / 足場非依存性増殖能 / HIC-5 / がん転移抑制 / 足場非依存性増殖 / 低酸素 / 血管新生 / 抗がん剤 / VEGF / 抗癌剤 / 細胞不死化 / 癌早期診断 / 診断マーカー / テロメラーゼ複合体 / テロメラーゼ遺伝子 / HPA法 / TRAP / 制癌剤 / 癌診断法 / hTERT / テロメア / 癌診断 / 不死化 / テロメラーゼ / 染色体外テロメア断片DNA / テロメア維持機構 Less

転移抑制を目指したRac1によるintegrin β4の分解抑制機構の解明
- Principal Investigator
  
  森一憲
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Showa University
Respiratory chain activity as a target of tumor-agnostic therapy in highly glycolytic/low respiratory tumorsPrincipal Investigator
- Principal Investigator
  
  柴沼質子
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Showa University
Impact of mitochondrial complex I activity on cancer cell proliferation: importance of NAD+ levels
- Principal Investigator
  
  Kazunori Mori
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Showa University
A mitochondrial ROS pathway controls matrix metalloproteinase 9 levels and invasive properties in RAS-activated cancer cells
- Principal Investigator
  
  Mori Kazunori
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Showa University
Significance of mitochondrial DNA mutations in cancer cells: induction of HMGA2 in response to DNA damagePrincipal Investigator
- Principal Investigator
  
  Shibanuma Motoko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Showa University
Novel therapeutic strategy for intractable inflammatory disease targeting PKCeta
- Principal Investigator
  
  Ohba Motoi
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Showa University
Suppressive role of the adaptor protein Hic-5 in anchorage-independent cell growth
- Principal Investigator
  
  KAZUNORI Mori
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Showa University
A potential role of mitochondria-mediated signaling in induction of malignancy and stemness by TGF.Principal Investigator
- Principal Investigator
  
  SHIBANUMA Motoko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Showa University
A novel cascade of TGF-β signaling dependent on mitochondrial reactive oxygen species and its biological significancePrincipal Investigator
- Principal Investigator
  
  SHIBANUMA Motoko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Showa University
細胞接着斑-核シャトル複合体による足場依存性増殖のための安全装置の破綻と癌化Principal Investigator
- Principal Investigator
  
  柴沼質子
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Showa University
Regulation of epithelial-mesenchymal transition (EMT) by redox-based mechanisms
- Principal Investigator
  
  NOSE Kiyoshi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
細胞接着斑蛋白質Hic-5による細胞膜-核シグナル伝達の制御機構Principal Investigator
- Principal Investigator
  
  柴沼質子
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Showa University
細胞接着斑蛋白質Hic-5によるがん細胞形質の調節機構Principal Investigator
- Principal Investigator
  
  柴沼質子
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Showa University
細胞老化関連遺伝子を標的とした新規抗がん剤の探索
- Principal Investigator
  
  野瀬清
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Showa University
Redox regulation of cell adhesion signals
- Principal Investigator
  
  NOSE Kiyoshi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
細胞接着斑蛋白質Hic-5によるがん細胞形質の調節機構Principal Investigator
- Principal Investigator
  
  柴沼質子
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Showa University
増殖制御遺伝子エンハンサーを用いた抗がん剤の探索
- Principal Investigator
  
  野瀬清
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Showa University
テロメラーゼ機能・テロメア維持機構の解明とその臨床応用
- Principal Investigator
  
  井出利憲
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Hiroshima University
細胞接着斑蛋白質Hic-5の細胞老化、がん化における役割
- Principal Investigator
  
  野瀬清
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Showa University
Regulation of adhesion signals by a focal adhesion protein, Hie5.Principal Investigator
- Principal Investigator
  
  SHIBANUMA Motoko
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  SHOWA UNIVERSITY
ANALYSIS OF CYTOPLASMIC FACTORS THAT PARTICIPATE IN GROWTH ARREST INDUCED BY OXIDATIVE STRESS
- Principal Investigator
  
  NOSE Kiyoshi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Biological pharmacy
- Research Institution
  SHOWA UNIVERSITY
Role of the Novel Gene, HIC-5, that encodes a Zn-finger Protein in Cellular Differentiation.Principal Investigator
- Principal Investigator
  
  SHIBANUMA Motoko
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  SHOWA UNIVERSITY
遅延型増殖抑制を起こす転写因子HIC-5遺伝子の機能Principal Investigator
- Principal Investigator
  
  柴沼質子
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Showa University
染色体末端テロメアによる遺伝子発現抑制の分子機構Principal Investigator
- Principal Investigator
  
  柴沼質子
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
細胞刺激により放出される活性酸素の標的蛋白の同定とアミノ酸配列の決定Principal Investigator
- Principal Investigator
  
  柴沼質子
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
TGFbetaで誘導されrasで発現の消失する遺伝子(HIC-5)の増殖における機能の解析Principal Investigator
- Principal Investigator
  
  柴沼質子
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Showa University
酸化ストレスによる細胞増殖抑制の分子機構
- Principal Investigator
  
  野瀬清
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Showa University
細胞刺激により放出される活性酸素の細胞内標的蛋白の同定とアミノ酸配列の決定Principal Investigator
- Principal Investigator
  
  柴沼質子
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
Reles of TGF beta-1 induckble novel gence in giowth regulation
- Principal Investigator
  
  NOSE Kiyoshi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University

[Journal Article] An indispensable role of TAZ in anoikis resistance promoted by OTUB1 deubiquitinating enzyme in basal-like triple-negative breast cancer cells2023
- Author(s)
  Hidetsugu Nakagawa, Masato Higurashi, Fumihiro Ishikawa, Kazunori Mori, Motoko Shibanuma
- Journal Title
  
  Biochem Biophys Res Commun .
  
  Volume: 649 Pages: 1-9
- DOI
  10.1016/j.bbrc.2023.01.080
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06917, KAKENHI-PROJECT-22K15516, KAKENHI-PROJECT-21K06809
[Journal Article] HMGA2 drives the IGFBP1/AKT pathway to counteract the increase in P27KIP1 protein levels in mtDNA/RNA-less cancer cells2022
- Author(s)
  Maruyama Tsuyoshi、Saito Koji、Higurashi Masato、Ishikawa Fumihiro、Kohno Yohko、Mori Kazunori、Shibanuma Motoko
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 1 Pages: 152
- DOI
  10.1111/cas.15582
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06809, KAKENHI-PROJECT-22K06917, KAKENHI-PROJECT-22K15516
[Journal Article] Rac1-mediated sustained β4 integrin level develops reattachment ability of breast cancer cells after anchorage loss.2021
- Author(s)
  Mori K, Higurashi M, Ishikawa F, Shibanuma M.
- Journal Title
  
  Cancer Sci.
  
  Volume: 112 Issue: 8 Pages: 3205-3217
- DOI
  10.1111/cas.14985
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07390
[Journal Article] Intracellular redox and mitochondrial regulaiton by transforming growth factor-b-its implication in induction of epithelial-mesenchymal transition2016
- Author(s)
  Motoko Shibanuma, Kazunori Mori, Fumihiro Ishikawa
- Journal Title
  
  J. Cell Signal.
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460399
[Journal Article] A HIC-5- and KLF4-dependent mechanism transactivates p21(Cip1) in response to anchorage loss.2012
- Author(s)
  Mori K, Hamanaka H, Oshima Y, Araki Y, Ishikawa F, Nose K, Shibanuma M.
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 287 Issue: 46 Pages: 38854-38865
- DOI
  10.1074/jbc.m112.377721
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590390
[Journal Article] A mobile molecular scaffold regulating the anchorage dependence of cell growth2011
- Author(s)
  Shibanuma, M., et.al.
- Journal Title
  
  Int J.Cell Biol.
  
  Volume: (in press) Pages: 1-8
- DOI
  10.1155/2012/426138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570205, KAKENHI-PROJECT-22790327
[Journal Article] Importance of mitochondrial dysfunction in oxidative stress responses : A comparative study of gene expression Profiles.2011
- Author(s)
  Motoko Shibanuma, et.al.
- Journal Title
  
  Free Radic.Res.
  
  Volume: 45 Pages: 672-680
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570205
[Journal Article] Importance of mitochondrial dysfunction in oxidative stress responses : A comparative study of gene expression profiles2011
- Author(s)
  Shibanuma, M., Inoue, A., Ushida, K., Uchida, T., Ishikawa, F., Mori, K., and Nose, K.
- Journal Title
  
  Free Radic. Res
  
  Volume: 45 Pages: 672-680
- Data Source
  KAKENHI-PROJECT-21570205
[Journal Article] Importance of mitochondrial dysfunction in oxidative stress responses : A comparative study of gene expression profiles2011
- Author(s)
  Shibanuma, M., et.al.
- Journal Title
  
  Free Radic.Res.
  
  Volume: 45 Pages: 672-680
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570205
[Journal Article] Transcriptional induction of MMP-10 by TGF-β, mediated by activation of MEF2A and downregulation class lla HDACs.2010
- Author(s)
  Ishikawa, F., Miyoshi, H., Nose, K., Shibanuma, M.
- Journal Title
  
  Oncogene 29
  
  Pages: 909-919
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570205
[Journal Article] Transcriptional induction of MMP-10 by TGF-., mediated by activation of MEF2A and down-regulation of class IIa HDACs2010
- Author(s)
  Ishikawa, F., Miyoshi, H., Nose, K., and Shibanuma, M.
- Journal Title
  
  Oncogene
  
  Volume: 29 Pages: 909-919
- Data Source
  KAKENHI-PROJECT-21570205
[Journal Article] TGF-βによる細胞内レドックス制御とミトコンドリア2010
- Author(s)
  柴沼質子
- Journal Title
  
  医学のあゆみ
  
  Volume: 234 Pages: 906-910
- Data Source
  KAKENHI-PROJECT-21570205
[Journal Article] Competitive nuclear export of cyclin D1 and Hic-5 regulates anchorage-dependence of cell growth and survival2009
- Author(s)
  Kazunori Mori, Etsuko Hirao, Yosuke Toya, Yukiko Oshima, Fumihiro Ishikawa, Kiyoshi Nose, Motoko Shibanuma
- Journal Title
  
  Mol. Biol Cell. 20
  
  Pages: 218-232
- Data Source
  KAKENHI-PROJECT-19570185
[Journal Article] Competitive nuclear export of cyclin D1 and Hic-5 regulates anchorage-dependence of cell growth and survival2009
- Author(s)
  Mori, K., Hirao, E., Toya, Y., Oshima, Y., Ishikawa, F., Nose, K., and Shibanuma, M.
- Journal Title
  
  Mol. Biol Cell
  
  Volume: 20 Pages: 218-232
- Data Source
  KAKENHI-PROJECT-21570205
[Journal Article] Gene expression profiling identifies a role for CHOP-10 during inhibition of the mitochondrial respiratory chain2009
- Author(s)
  Ishikawa, F., Akimoto, T., Yamamoto, H., Araki, Y., Yoshie, T., Mori, K., Hayashi, H., Nose, K., and Shibanuma, M.
- Journal Title
  
  J. Biochem
  
  Volume: 146 Pages: 123-132
- Data Source
  KAKENHI-PROJECT-21570205
[Journal Article] Downregulation of hepatocyte nuclear factor-4α and its role in regulation of gene expression by TGF-β in mammary epithelial cells2008
- Author(s)
  Fumihiro, Ishikawa, Takashi Akimoto, Haruka Yamamoto, Yuri Araki, Toshihiko Yoshie, Kazunori Mori, Hidetoshi Hayashi, Kiyoshi Nose, Motoko Shibanuma
- Journal Title
  
  Exp. Cell Res. 314
  
  Pages: 2131-2141
- Data Source
  KAKENHI-PROJECT-19570185
[Journal Article] Characterization of Jumping translocation breakpoint (JTB) gene product isolated as a TGF-β1-inducible clone involved in regulation of mitochondrial function, cell growth and death.2007
- Author(s)
  Kanome, T., Itoh, N., Mori, K., Kim-Kaneyama, J., Shibanuma, M., Nose, K.
- Journal Title
  
  Oncogene (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Induction of Matrix Metalloprotease Gene Expression in an Endothelial Cell Line by Direct Interaction with Malignant Cells.2007
- Author(s)
  Hasebe, Y., Egawa, K., Shibanuma, M., Nose, K
- Journal Title
  
  Cancer Sc. 98巻・1号
  
  Pages: 58-67
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Induction of Matrix Metalloprotease Gene Expression in an Endothelial Cell Line by Direct Interaction with Malignant Cells.2007
- Author(s)
  Hasebe, Y., Egawa, K., Shibanuma, M., Nose, K
- Journal Title
  
  Cancer Sci. 98巻・1号
  
  Pages: 58-67
- Data Source
  KAKENHI-PROJECT-18013047
[Journal Article] Characterization of Jumping translocation breakpoint (JTB) gene product isolated as a TGF-β1-inducible clone involved in regulation of mitochondrial function, cell growth and death.2007
- Author(s)
  Kanome, T., Itho, N., Mori, K., Kim-Kaneyama, J., Shibanuma, M., Nose, K.
- Journal Title
  
  Oncogene. in press
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Induction of Matrix Metalloprotease Gene Expression on an Endothelial Cell Line by Direct Interaction with Malignant Cells.2007
- Author(s)
  Hasebe, Y., Egawa, K., Shibanuma, M., Nose, K
- Journal Title
  
  Cancer Sci. 98巻・1号
  
  Pages: 58-67
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Characterization of Jumping translocation breakpoint (JTB) gene product isolated as a TGF-β1-inducible clone involved in regulation of mitochondrial function, cell growth and death.2007
- Author(s)
  Kanome, T., Itoh, N., Mori, K., Kim-Kaneyama, J., Shibanuma, M., Nose, K.
- Journal Title
  
  Oncogene. (in press)
- Data Source
  KAKENHI-PROJECT-18013047
[Journal Article] Induction of Matrix Metalloprotease Gene Expression in an Endothelial Cell Line by Direct Interaction with Malignant Cells2007
- Author(s)
  Hasebe, Y., Egawa, K., Shibanuma, M., Nose, K.
- Journal Title
  
  Cancer Sc. 98
  
  Pages: 58-67
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Oligomerizing potential of a focal adhesion LIM protein Hic-5 organizing a nuclear-cytoplasmic shuttling complex.2006
- Author(s)
  Mori, K., Asakawa, M., Hayashi, M., Imura, M., Ohki, T., Hirao, E., Nose, K., Shibanuma, M.
- Journal Title
  
  J.Biol.Chem. 281
  
  Pages: 22048-22061
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Inhibition of angiogenesis and HIF-1a activation by antimycin A1.2006
- Author(s)
  Maeda, M., Hasebe, Y., Egawa, K., Shibanuma, M., Nose, K.
- Journal Title
  
  Biol. Pharm. Bullet. 29巻・7号
  
  Pages: 1344-1348
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Inhibition of angiogenesis and HIF-la activation by antimycin A1.2006
- Author(s)
  Maeda, M., Hasebe, Y, Egawa, K., Shibanuma, M., Nose, K.
- Journal Title
  
  Biol.Pharm.Bullet. 29
  
  Pages: 1344-1348
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Inhibition of angiogenesis and HIF-la activation by antimycin A1.2006
- Author(s)
  Maeda, M., Hasebe, Y., Egawa, K., Shibanuma, M., Nose, K.`
- Journal Title
  
  Biol. Pharm. Bullet. 29巻・7号
  
  Pages: 1344-1348
- Data Source
  KAKENHI-PROJECT-18013047
[Journal Article] Oligomerizing potential of a focal adhesion LIM protein Hic-5 organizing a nuclear-cytoplasmic shuttling complex.2006
- Author(s)
  Mori, K., Asakawa, M., Hayashi, M., Imura, M., Ohki, T., Hirao, E., Nose, K., Shibanuma, M.
- Journal Title
  
  J. Biol. Chem. 281巻・31号
  
  Pages: 22048-22061
- Data Source
  KAKENHI-PROJECT-18013047
[Journal Article] Inhibition of angiogenesis and HIF-1a activation by antimycin A1.2006
- Author(s)
  Maeda, M., Hasebe, Y., Egawa, K., Shibanuma, M., Nose, K.
- Journal Title
  
  Biol. Pharm. Bullet :. 29巻・7号
  
  Pages: 1344-1348
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Oligomerizing potential of a focal adhesion LIM protein Hic-5 organizing a nuclear-cytoplasmic shuttling complex.2006
- Author(s)
  Mori, K., Asakawa, M., Hayashi, M., Imura, M., Ohki, T., Hirao, E., Nose, K., Shibanuma, M.
- Journal Title
  
  J. Biol. Chem. 281巻・31号
  
  Pages: 22048-22061
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Involvement of FAK and PTP-PEST in the regulation of redox-sensitive nuclear-cytoplasmic shuttling of a LIM protein, Hic-5.2005
- Author(s)
  M.Shibanuma, K.Mori, J.Kim-Kaneyama, K.Nose.
- Journal Title
  
  Antioxidants ＆ Redox Signaling 7
  
  Pages: 335-347
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Uni-axial stretch regulates intracellular localization of Hic-5, which is expressed in smooth muscle cells in vivo.2005
- Author(s)
  Kaneyama, A., Nose, K., Shibanuma, M.
- Journal Title
  
  J. Cell Sci. 118巻・2号
  
  Pages: 937-949
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Involvement of FAK and PTP-PEST in the regulation of redox-sensitive nuclear-cytoplasmic shuttling of a LIM protein, Hic-52005
- Author(s)
  M.Shibanuma, K.Mori, Joo-riKim-Kaneyama, K.Nose
- Journal Title
  
  Antioxidants & Redox Signaling 7(3&4)
  
  Pages: 335-347
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Uni-axial stretch regulates intracellular localization of Hic-5, which is expressed in smooth muscle cells in vivo.2005
- Author(s)
  Kaneyama, A., Nose, K., Shibanuma, M.
- Journal Title
  
  J.Cell Sci. 118
  
  Pages: 937-949
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Uni-axial stretching regulates intracellular localization of Hic-5, which is expressed in smooth muscle cells in vivo.2005
- Author(s)
  Shuri Kaneyama, Kiyoshi Nose, Motoko Shibanuma
- Journal Title
  
  J.Cell Sci. 118(5)
  
  Pages: 937-949
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Involvement of FAX and PTP-PEST in the regulation of redox-sensitive nuclear-cytoplasmic shuttling of a LIM protein, Hic-52005
- Author(s)
  M.Shibanuma, K.Mori, Joo-ri Kim-Kaneyama, K.Nose
- Journal Title
  
  Antioxidants & Redox Signaling (In press)
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Uni-axial stretch regulates intracellular localization of Hic-5, which is expressed in smooth muscle cells in vivo.2005
- Author(s)
  Shuri Kaneyama, Kiyoshi Nose, Motoko Shibanuma
- Journal Title
  
  J.Cell Sci. (In press)
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Involvement of FAK and PTP-PEST in the regulation of redox-sensitive nuclear-cytoplasmic shuttling of a LIM protein, Hic-52005
- Author(s)
  M.Shibanuma, K.Mori, J.Kim-Kaneyama, K.Nose.
- Journal Title
  
  Antioxidants ＆ Redox Signaling 7巻・2号
  
  Pages: 335-347
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] A LIM protein, Hic-5, functions as a potential coactivator for Sp1.2004
- Author(s)
  Shibanuma, M., Kim-Kaneyama, J., Sato, S., Nose.K.
- Journal Title
  
  J.Cell. Biochern. 91
  
  Pages: 633-645
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Invasive potential induced under long-term oxidative stress in mammary epithelial cells.2004
- Author(s)
  Kazunori Mori, Motoko Shibanuma. Kivoshi Nose
- Journal Title
  
  Cancer Res. 64
  
  Pages: 7464-7472
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] HIC-5 : A mobile molecular scaffold regulating the anchorage dependence of cell growth
- Author(s)
  Shibanuma, M., Mori, K., and Nose, K.
- Journal Title
  
  Int J. Cell Biol
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-21570205
[Journal Article] Characterization of Jumping translocation breakpoint (JTB) gene produc1 isolated as a TGF-pl-inducible clone involved in regulation of mitochondrial function, cell growth and death.
- Author(s)
  Kanome, T., Itoh, N., Mori, K., Kim-Kaneyama, J., Shibanuma, M., Nose, K.
- Journal Title
  
  Uncogene (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390025
[Journal Article] Gene expression profiling identifies a role for CHOP during inhibition of the mitochondrial respiratory chain
- Author(s)
  Fumihiro Ishikawa, Kiyoshi Nose, Motoko Shibanuma
- Journal Title
  
  J. Biochem. (Epub ahead of print)
- NAID
  10025187713
- Data Source
  KAKENHI-PROJECT-19570185
[Presentation] NAD+-SIRT3/6によるp21Cip1発現制御と癌細胞増殖制御2023
- Author(s)
  日暮大渡、森一憲、中川　英嗣、石川文博、柴沼質子
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K06809
[Presentation] HMGA2/IGFBP1/AKT経路によるP27KIP1分解機構の制御と癌治療標的としての意義2022
- Author(s)
  丸山剛、齊藤光次、日暮大渡、石川文博、河野葉子、森一憲、柴沼質子
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K06809
[Presentation] Role of TAZ in promoting cell survival upon anchorage loss in breast cancer cells2022
- Author(s)
  Hidetsugu Nakagawa, Fumihiro Ishikawa, Kazunori Mori, Motoko Shibanuma
- Organizer
  The 81 st annual meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-22K06917
[Presentation] HMGA2 is critical for sustaining cell proliferation in mtDNA-less hepatocellular carcinoma cells2021
- Author(s)
  Tsuyoshi Maruyama, Masato Higurashi, Kazunori Mori, Motoko Shibanuma
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07390
[Presentation] Epigenetic control of p21Cip1 expression and cell proliferation by respiratory chain complex I via NAD+ supply2021
- Author(s)
  Masato Higurashi, Kazunori Mori, Fumihiro Ishikawa, Motoko Shibanuma
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07390
[Presentation] Rac1-mediated and sustained β4 integrin expression supports persistence of reattachment ability in breast cancer cells2021
- Author(s)
  Kazunori Mori, Masato Higurashi, Fumihiro Ishikawa, Motoko Shibanuma
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07390
[Presentation] The impact of mitochondrial complex I activity on p21Cip1 expression: the importance of NAD+ levels2020
- Author(s)
  Kazunori Mori, Masato Higurashi, Fumihiro Ishikawa, Motoko Shibanuma
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07390
[Presentation] Impact of mitochondrial complex I activity on cancer cell proliferation: importance of NAD+ levels2019
- Author(s)
  Mori, K., Higurashi, M., Ishikawa, F., and Shibanuma, M.
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07390
[Presentation] ミトコンドリア呼吸鎖複合体IはNAD+の供給を介してp21Cip1の発現を制御する2019
- Author(s)
  日暮大渡、森一憲、石川文博、柴沼質子
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07390
[Presentation] The HIC-5-NOX4-mtROS axis regulates metastasis of RAS-activated cancer cells by affecting MMP9 mRNA stability2017
- Author(s)
  Kazunori Mori, Tetsu Uchida, Toshihiko Yoshie, Yuko Mizote, Fumihiro Ishikawa, Masato Katsuyama, and Motoko Shibanuma
- Organizer
  EMBO Conference on Redox Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08317
[Presentation] HIC-5によるNOX4依存性細胞内レドックス制御とMMP-9発現制御2016
- Author(s)
  森一憲、石川文博、柴沼質子
- Organizer
  第75回　日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26460399
[Presentation] ポリコームタンパク質SUZ12は乳がん細胞の足場非依存的な生存を促進する2016
- Author(s)
  石川文博、森一憲、柴沼質子
- Organizer
  第75回　日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-26460399
[Presentation] HIC-5 acts as a negative regulator for MMP-9 expression by inhibiting NOX4 expression in oncogenic RAS-driven cancers2016
- Author(s)
  Kazunori Mori, Fumihiro Ishikawa, and Motoko Shibanuma
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K08317
[Presentation] 肝細胞がんに対する新規治療戦略：ATM/ATR-HMGA2経路の遮断による老化形質誘導の可能性2016
- Author(s)
  日暮大渡、斉藤光次、河野葉子、石川文博、森一憲、青木武士、村上雅彦、瀧本雅文、柴沼質子
- Organizer
  第75回　日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26460399
[Presentation] Mitochondrial activity is essential for cancer cell growth regulating a core cell cycle regulator E2F1 and cyclins2015
- Author(s)
  Motoko Shibanuma
- Organizer
  The 74rd annual meeting of the Japanese cancer association
- Place of Presentation
  Nagoya
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-26460399
[Presentation] ミトコンドリア機能不全によるHMGA2誘導の意義：肝細胞がんの増殖能維持とEMT誘導への関与2014
- Author(s)
  柴沼質子
- Organizer
  第73回　日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-26460399
[Presentation] Phenotypic disruption of mammary epithelial cells caused by mitochondrial dysfunction and the underlying mechanisms2012
- Author(s)
  Shibanuma, M., Mori, K., Ishikawa, F.
- Organizer
  Keystone Symposia
- Place of Presentation
  Banff, Albert, Canada
- Data Source
  KAKENHI-PROJECT-21570205
[Presentation] Phenotypic disruption of mammary epithelial cells caused by mitochondrial dysfunction and the underlying Mechanisms2012
- Author(s)
  Shibanuma, M., Mori, K., Ishikawa, F.
- Organizer
  Keystone Symposia
- Place of Presentation
  Banff, Albert, Canada
- Data Source
  KAKENHI-PROJECT-21570205
[Presentation] Adhesion-sensitive transcriptional regulation of p21Cip is dependent on the molecular scaffold HIC-5 and KLF42012
- Author(s)
  Kazunori Mori, Fumihiro Ishikawa, Motoko Shibanuma
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌
- Data Source
  KAKENHI-PROJECT-24590390
[Presentation] ミトコンドリア機能不全によるEMTプログラムの活性化と上皮形質の破綻2011
- Author(s)
  柴沼質子、森一憲、石川文博
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-21570205
[Presentation] 細胞接着斑蛋白質Hic-5によるがん細胞の足場非依存性増殖/造腫瘍能の抑制性制御2011
- Author(s)
  森一憲、石川文博、柴沼質子
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-21570205
[Presentation] Phenotypic disruption of mammary epithelial cells caused by mitochondrial dysfunction and the underlying mechanisms2011
- Author(s)
  Shibanuma, M., Mori, K., Ishikawa, F.
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21570205
[Presentation] ミトコンドリア機能不全により誘導される上皮細胞形質の変化2010
- Author(s)
  石川文博、森一憲、柴沼質子
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21570205
[Presentation] ミトコンドリア特異的転写因子TFAM発現抑制による腫瘍の転移能抑制の可能性2010
- Author(s)
  内田徹、石川文博、森一憲、柴沼質子
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21570205
[Presentation] Mitochondria-mediated signaling cascade plays a role in the regulation of gene expression by TGF2010
- Author(s)
  Shibanuma, M., Kaneko, E., Sugimoto, T., Wakamatsu, M., Mori, K., Ishikawa, F.
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21570205
[Presentation] Mitochondria-mediated signaling cascade plays a role in the regulation of gene expression by TGF-β2010
- Author(s)
  Motoko Shibanuma, et.al.
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21570205
[Presentation] Transcriptional induction of MMP10 by TGFβ mediated by MEF2 and class IIa HDACs2009
- Author(s)
  Fumihiro Ishikawa, Emi Kaneko, Toshihiko Yoshie, Kiyoshi Nose, and Motoko Shibanuma
- Organizer
  Keystone Symposia
- Place of Presentation
  Vancouver, British Columbia, Canada.
- Year and Date
  2009-03-17
- Data Source
  KAKENHI-PROJECT-19570185
[Presentation] ミトコンドリア由来ROSによるTGFβ遺伝子発現の抑制的制御機構の存在について2009
- Author(s)
  石川文博、金子瑛美、柴沼質子
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21570205
[Presentation] Transcriptional induction of MMP10 by TGF. mediated by MEF2 and class IIa HDACs2009
- Author(s)
  Ishikawa, F., Kaneko, E., Yoshie, T., Nose, K., Shibanuma, M.
- Organizer
  Keystone Symposia
- Place of Presentation
  Vancouver, British Columbia, Canada
- Year and Date
  2009-03-17
- Data Source
  KAKENHI-PROJECT-21570205
[Presentation] ミトコンドリア由来ROSによるTGFβ遺伝子発現の抑制的制御機構の存在について2009
- Author(s)
  石川文博, 金子瑛美, 柴沼質子
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-21570205
[Presentation] TGFβによるMEF2とClassIIaHDACを介したMMP10転写制御機構2008
- Author(s)
  石川文博、野瀬清、柴沼質子
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-19570185
[Presentation] MMP9の発現制御に特異的に関わる新規TGFβ転写制御機構の解析2008
- Author(s)
  三瓶瑠利子、石川文博、野瀬清、柴沼質子
- Organizer
  第31回日本分子生物学会年会第81回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-19570185
[Presentation] ミトコンドリア機能の変化と細胞の悪性化形質誘導2007
- Author(s)
  柴沼質子
- Organizer
  第30回日本分子生物学会、第80回日本生化学会、合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18013047
[Presentation] ミトコンドリア機能の変化と細胞の悪性化形質誘導2007
- Author(s)
  柴沼質子
- Organizer
  第30回日本分子生物学会、第80回日本生化学会、合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19570185
[Presentation] HIC-5 regulates TGF-b-stimulated MMP-9 expression, anchorage-independent growth, and metastasis of breast cancer cells
- Author(s)
  Kazunori MORI, Fumihiro ISHIKAWA, Motoko SHIBANUMA
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24590390

1. NOSE Iyoshi (70012747)

# of Collaborated Projects: 15 results

# of Collaborated Products: 31 results
2. MASHIMO Junichi (60054045)

# of Collaborated Projects: 11 results

# of Collaborated Products: 0 results
3. MORI Kazunori (60349040)

# of Collaborated Projects: 11 results

# of Collaborated Products: 46 results
4. EGAWA Kiyoshi (00095879)

# of Collaborated Projects: 9 results

# of Collaborated Products: 6 results
5. NISHIYA Naoyuki (10286867)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
6. ISHIKAWA Fumihiro (60515667)

# of Collaborated Projects: 7 results

# of Collaborated Products: 35 results
7. KANEYAMA Syuri (10338535)

# of Collaborated Projects: 5 results

# of Collaborated Products: 13 results
8. ARATA Satoru (20159502)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
9. Ohba Motoi (70297018)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
10. 國元節子 (10161655)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 日暮大渡 (50882487)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
12. Kohno Yohko (40195681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 井出利憲 (60012746)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 清宮啓之 (50280623)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 檜山佳子 (60253069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 清水素行 (80130756)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 石川冬木 (30184493)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Shibanuma Motoko 柴沼 質子

柴沼 質子 シバヌマ モトコ

SHIBANUMA Motoko 柴沼 質子

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Respiratory chain activity as a target of tumor-agnostic therapy in highly glycolytic/low respiratory tumorsPrincipal Investigator

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Significance of mitochondrial DNA mutations in cancer cells: induction of HMGA2 in response to DNA damagePrincipal Investigator

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A potential role of mitochondria-mediated signaling in induction of malignancy and stemness by TGF.Principal Investigator

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A novel cascade of TGF-β signaling dependent on mitochondrial reactive oxygen species and its biological significancePrincipal Investigator

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細胞接着斑-核シャトル複合体による足場依存性増殖のための安全装置の破綻と癌化Principal Investigator

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細胞接着斑蛋白質Hic-5による細胞膜-核シグナル伝達の制御機構Principal Investigator

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細胞接着斑蛋白質Hic-5によるがん細胞形質の調節機構Principal Investigator

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Shibanuma Motoko 柴沼質子

柴沼質子シバヌマモトコ

SHIBANUMA Motoko 柴沼質子