Shinohara Masahiro 篠原正浩

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SHINOHARA Masahiro 篠原正浩

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Researcher Number	60345733
Other IDs
Affiliation (Current)	2025: 国立障害者リハビリテーションセンター(研究所), 研究所運動機能系障害研究部, 研究室長
Affiliation (based on the past Project Information) *help	2018 – 2025: 国立障害者リハビリテーションセンター(研究所), 研究所運動機能系障害研究部, 研究室長 2016 – 2018: 東京医科歯科大学, 大学院医歯学総合研究科, 講師 2015: 東京医科歯科大学, 医歯(薬)学総合研究科, 講師 2012: 東京医科歯科大学, 医歯(薬)学総合研究科, 講師 2012: 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 … More 2012: 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 2011: 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 2010 – 2011: 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 2009: 東京医科歯科大学, 医歯学総合研究科, 助教 2007: 東京医科歯科大学, 大学院・医歯学総合研究科, Research Associate 2005 – 2006: 東京医科歯科大学, 大学院医歯学総合研究科, 助手 2003 – 2005: 信州大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / General medical chemistry / Transformative Research Areas, Section (IV) / Basic Section 59010:Rehabilitation science-related / Complex Systems Disease Theory / Complex systems / Orthopaedic surgery / Functional basic dentistry Except Principal Investigator Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Orthopaedic surgery / Pathological medical chemistry / Biological Sciences
Keywords	Principal Investigator 骨代謝 / 骨粗鬆症 / 破骨細胞 / PI3K / メカニカルストレス / RANKL / 骨細胞 / 不動性骨粗鬆症 / 微小重力 / チロシンリン酸化タンパク質 … More / ミトコンドリア / 遺伝子改変マウス / シアストレス / GPCR / 不動性骨粗しょう症 / 重力 / シミュレーション / 軟骨代謝 / 数理シミュレーション / 予測シミュレーション / 骨代謝マーカー / 画像解析 / 数理モデル / 血中マーカー / 変形性関節症 / 微小重力環境 / 骨形成 / 骨芽細胞 / 筋肉 / 脂肪 / メタボリックシンドローム / 2型糖尿病 / 肥満 / 大理石骨病マウス / 骨芽細胞分化 / 破骨細胞分化 / 骨粗しょう症 / 関節リウマチ / 歯周病 / チロシンキナーゼ / 細胞内情報伝達 / GTP結合タンパク質 / Nox1 / Rho / Transformation / 活性酸素 / NADPH oxidase 1 / Ras … More Except Principal Investigator メカニカルストレス / Ras / Nox1 / 生体恒常性維持 / 身体不活動 / 抗炎症 / 恒常性維持 / 適度な運動 / 破骨細胞 / 骨疾患 / 骨免疫学 / 情報伝達 / 転移 / MAPkinase / RNAi / 癌 / 活性酸素 / 間質液 / 運動模倣介入 / 慢性炎症 / 筋萎縮 / 抗老化 / 炎症 / 運動器 / 生体恒常性 / リハビリテーション / Osteoimmunology / Osteoporosis / Transcription factor / Osteoclast / Periodontitis / Rheumatoid arthritis / Bone destruction / Bone disease / 遺伝子改変動物 / 転写因子 / 骨破壊 / 歯周病 / 関節リウマチ / Nox4 / melanoma / pancreatic cancer / cancer / redox signaling / reactive oxygen species / MAP Kinase / メラノーマ / 膵癌 / 大腸癌 / MAPKinase / レドックスシグナリング / 細胞・組織 / 免疫学 / 生理学 / シグナル伝達 / 整形外科学 / 骨代謝学 / プロテオーム / トランスクリプトーム / ノックアウトマウス / Th17細胞 / 骨細胞 / リンパ球 / 骨芽細胞 / 疾患モデル / 自己免疫 / 骨代謝 Less

RANKL発現を基軸とした不動性骨粗鬆症の発症機序解明Principal Investigator
- Principal Investigator
  
  篠原正浩
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
骨・骨髄環境の重力制御から迫る進化と宇宙環境への適応Principal Investigator
- Principal Investigator
  
  篠原正浩
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (IV)
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
力学の理解に基づく代謝異常症及び認知機能障害に対する革新的治療法開発の基盤構築
- Principal Investigator
  
  澤田泰宏
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
身体不活動による骨量低下の分子機序解明と骨量低下抑制法の確立Principal Investigator
- Principal Investigator
  
  篠原正浩
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
Molecular mechanisms of how mechanical stresses alleviate chronic inflammation of the brain and muscles induced by physical inactivity
- Principal Investigator
  
  Sawada Yasuhiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
Mechanism for suppression of osteoclastic bone resorption by mechanical stress in bonePrincipal Investigator
- Principal Investigator
  
  Masahiro Shinonara
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
Systems Bone BiologyPrincipal Investigator
- Principal Investigator
  
  Shinohara Masahiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Complex Systems Disease Theory
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
骨代謝を制御する重力シグナルにおけるPI3Kの重要性の解明Principal Investigator
- Principal Investigator
  
  篠原正浩
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
Molecular Mechanisms of How Mechanical Stress Regulates Inflammation of Locomotive Organs
- Principal Investigator
  
  Sawada Yasuhiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
宇宙における骨量低下の謎に迫る―破骨細胞分化因子RANKLの発現メカニズムの解明Principal Investigator
- Principal Investigator
  
  篠原正浩
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tokyo Medical and Dental University
A novel mechanism for osteoblastic bone formation regulated by osteocytesPrincipal Investigator
- Principal Investigator
  
  Shinohara Masahiro
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical and Dental University
Role of osteoclasts in metabolic syndromePrincipal Investigator
- Principal Investigator
  
  SHINOHARA Masahiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Medical and Dental University
Basic research for the understanding of osteoclast-specific systemsPrincipal Investigator
- Principal Investigator
  
  SHINOHARA Masahiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Tokyo Medical and Dental University
Transcriptional regulation of osteoclastogenesis
- Principal Investigator
  
  ASAGIRI Masataka
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical and Dental University
Osteoimmunology
- Principal Investigator
  
  TAKAYANAGI Hiroshi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Creative Scientific Research
- Research Institution
  Tokyo Medical and Dental University
活性酸素産生癌遺伝子Nox1を標的としたRas・ヒト発癌機構の解析
- Principal Investigator
  
  KAMATA Tohru
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Shinshu University
The functional role of a superoxide generating gene Nox1 in Ras oncogene-induced transformation and human tumor development
- Principal Investigator
  
  KAMATA Tohru
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Shinshu University School of Medicine
細胞癌化を媒介する活性酸素産生酵素Nox1による情報戦たつ機構の解明Principal Investigator
- Principal Investigator
  
  篠原正浩
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Shinshu University

[Book] 実験医学2019
- Author(s)
  篠原正浩
- Total Pages
  5
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-18KT0018
[Book] 実験医学2019
- Author(s)
  篠原正浩
- Total Pages
  5
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-19H03991
[Book] 実験医学2019
- Author(s)
  篠原正浩
- Total Pages
  5
- Publisher
  羊土社
- Data Source
  KAKENHI-PUBLICLY-18H04970
[Book] 分子リウマチ治療、「次世代の分子ターゲット　Btk」2016
- Author(s)
  篠原正浩、高柳広
- Total Pages
  5
- Publisher
  先端医学社
- Data Source
  KAKENHI-PUBLICLY-16H01634
[Book] THE BONE、「免疫複合体はFcRγシグナルを介して骨代謝を制御する」2016
- Author(s)
  篠原正浩
- Total Pages
  1
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-15K15540
[Book] 実験医学別冊『マウス表現型解析パーフェクトガイド』、「骨組織系の表現系解析」2016
- Author(s)
  篠原正浩、浅原弘嗣
- Total Pages
  10
- Publisher
  羊土社
- Data Source
  KAKENHI-PUBLICLY-16H01634
[Book] 免疫複合体はFcRγシグナルを介して骨代謝を制御する」、THE BONE2016
- Author(s)
  篠原正浩
- Total Pages
  1
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-15K15540
[Book] THE BONE、「IgG抗体の糖鎖修飾が破骨細胞分化と骨量減少を決定する」2016
- Author(s)
  篠原正浩
- Total Pages
  1
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-15K15540
[Book] 分子リウマチ治療、「次世代の分子ターゲット　Btk」2016
- Author(s)
  篠原正浩、高柳広
- Total Pages
  5
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-15K15540
[Book] 「次世代の分子ターゲット　Btk」、分子リウマチ治療2016
- Author(s)
  篠原正浩、高柳広
- Total Pages
  5
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-15K15540
[Book] THE BONE、「IgG抗体の糖鎖修飾が破骨細胞分化と骨量減少を決定する」2016
- Author(s)
  篠原正浩
- Total Pages
  1
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PUBLICLY-16H01634
[Book] THE BONE、「免疫複合体はFcRγシグナルを介して骨代謝を制御する」2016
- Author(s)
  篠原正浩
- Total Pages
  1
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PUBLICLY-16H01634
[Book] 「IgG抗体の糖鎖修飾が破骨細胞分化と骨量減少を決定する」、THE BONE2016
- Author(s)
  篠原正浩
- Total Pages
  1
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-15K15540
[Book] 実験医学別冊『マウス表現型解析パーフェクトガイド』、「骨組織系の表現系解析」2016
- Author(s)
  篠原正浩、浅原弘嗣
- Total Pages
  10
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-15K15540
[Book] 「骨免疫学総論」、炎症と免疫2015
- Author(s)
  篠原正浩
- Total Pages
  7
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-15K15540
[Book] 「骨ペディア　骨疾患・骨代謝キーワード事典」2015
- Author(s)
  篠原正浩
- Total Pages
  3
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-15K15540
[Book] 骨免疫学の最前線2012
- Author(s)
  篠原正浩、高柳広
- Data Source
  KAKENHI-PROJECT-22689048
[Book] 炎症と免疫Vol.20 No.2(2012年3月)2012
- Author(s)
  篠原正浩、高柳広
- Total Pages
  4
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-22689048
[Book] 骨免疫学2012
- Author(s)
  篠原正浩、高柳広
- Data Source
  KAKENHI-PROJECT-23659149
[Book] 骨免疫学の最前線2012
- Author(s)
  篠原正浩、高柳広
- Data Source
  KAKENHI-PROJECT-23659149
[Book] 腎と骨代謝Vol.25 No.2(2012年3月)2012
- Author(s)
  篠原正浩、高柳広
- Total Pages
  8
- Publisher
  日本メディカルセンター
- Data Source
  KAKENHI-PROJECT-22689048
[Book] 骨免疫学2012
- Author(s)
  篠原正浩、高柳広
- Data Source
  KAKENHI-PROJECT-22689048
[Book] 炎症と免疫 Vol. 20 No.22012
- Author(s)
  篠原　正浩、高柳　広
- Total Pages
  4
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-23659149
[Book] 腎と骨代謝 Vol.25 No.22012
- Author(s)
  篠原　正浩、高柳　広
- Total Pages
  8
- Publisher
  日本メディカルセンター
- Data Source
  KAKENHI-PROJECT-23659149
[Book] 「炎症と免疫」7月号2010
- Author(s)
  篠原正浩、高柳広
- Total Pages
  9
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-22689048
[Book] 新規分子を標的とした抗破骨細胞療法2010
- Author(s)
  篠原正浩、高柳広
- Data Source
  KAKENHI-PROJECT-22689048
[Book] Annual Review 免疫 20072006
- Author(s)
  篠原正浩, 高柳広
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-17GS0313
[Book] NFATc1による破骨細胞分化のメカニズム、Annual Review 免疫2007(編集 : 奥村康、平野俊夫、佐藤昇志)2006
- Author(s)
  篠原正浩, 高柳広
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-17GS0313
[Journal Article] Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans2023
- Author(s)
  Murase Shuhei、Sakitani Naoyoshi、Maekawa Takahiro、Yoshino Daisuke、Takano Kouji、Konno Ayumu、Hirai Hirokazu、Saito Taku、et al
- Journal Title
  
  Nature Biomedical Engineering
  
  Volume: 7 Issue: 11 Pages: 1350-1373
- DOI
  10.1038/s41551-023-01061-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18325, KAKENHI-PROJECT-23K16632, KAKENHI-PROJECT-22K06454, KAKENHI-PROJECT-21K11330, KAKENHI-PROJECT-21K19552, KAKENHI-PROJECT-22K19761, KAKENHI-PROJECT-21H04688, KAKENHI-PROJECT-21H04866, KAKENHI-PROJECT-23K24467, KAKENHI-PROJECT-23K27718, KAKENHI-PROJECT-23K27906
[Journal Article] Application of Passive Head Motion to Generate Defined Accelerations at the Heads of Rodents2022
- Author(s)
  Maekawa Takahiro、Sakitani Naoyoshi、Ryu Youngjae、Takashima Atsushi、Murase Shuhei、Fink Julius、Nagao Motoshi、Ogata Toru、Shinohara Masahiro、Sawada Yasuhiro
- Journal Title
  
  Journal of Visualized Experiments
  
  Volume: - Issue: 185 Pages: 363100-363100
- DOI
  10.3791/63100
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K11330, KAKENHI-PROJECT-22K19761, KAKENHI-PROJECT-21H04866, KAKENHI-PROJECT-20K19367
[Journal Article] Findings from recent studies by the Japan Aerospace Exploration Agency examining musculoskeletal atrophy in space and on Earth2021
- Author(s)
  Furukawa Satoshi、Chatani Masahiro、Higashitani Atsushi、Higashibata Akira、Kawano Fuminori、Nikawa Takeshi、Numaga-Tomita Takuro、Ogura Toshihiko、Sato Fuminori、Sehara-Fujisawa Atsuko、Shinohara Masahiro、Shimazu Toru、Takahashi Satoru、Watanabe-Takano Haruko
- Journal Title
  
  npj Microgravity
  
  Volume: 7 Issue: 1 Pages: 18-18
- DOI
  10.1038/s41526-021-00145-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03991, KAKENHI-PROJECT-19H04054, KAKENHI-PROJECT-21K06255
[Journal Article] Gravity sensing in plant and animal cells.2021
- Author(s)
  Takahashi K, Takahashi H, Furuichi T, Toyota M, Furutani-Seiki M, Kobayashi T, Watanabe-Takano H, Shinohara M, Numaga-Tomita T, Sakaue-Sawano A, Miyawaki A, Naruse K.
- Journal Title
  
  NPJ Microgravity
  
  Volume: 7 Issue: 1 Pages: 2-2
- DOI
  10.1038/s41526-020-00130-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07116, KAKENHI-PROJECT-20K08956, KAKENHI-PROJECT-20K21896, KAKENHI-PLANNED-18H05491, KAKENHI-PROJECT-19H03140, KAKENHI-PROJECT-18K09050, KAKENHI-PROJECT-18K19291, KAKENHI-PROJECT-19H03991
[Journal Article] Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis.2021
- Author(s)
  Ito Y, Matsuzaki T, Ayabe F, Mokuda S, Kurimoto R, Matsushima T, Tabata Y, Inotsume M, Tsutsumi H, Liu L, Shinohara M, Tanaka Y, Nakamichi R, Nishida K, Lotz MK, Asahara H.
- Journal Title
  
  Nat Commun
  
  Volume: 12 Issue: 1 Pages: 4148-4148
- DOI
  10.1038/s41467-021-24460-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16794, KAKENHI-PROJECT-19H03991, KAKENHI-PROJECT-20H05696
[Journal Article] Mechanical regulation underlies effects of exercise on serotonin-induced signaling in the prefrontal cortex neurons.2020
- Author(s)
  Ryu Y, Maekawa T, Yoshino D, Sakitani N, Takashima A, Inoue T, Suzurikawa J, Toyohara J, Tago T, Fujita N, Sawada K, Murase S, Watanave M, Sakai T, Yoshikawa Y, Ogata T, Shinohara M, Nagao M, Sawada Y
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 2 Pages: 100874-100874
- DOI
  10.1016/j.isci.2020.100874
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KT0018, KAKENHI-PROJECT-18K07658, KAKENHI-PLANNED-17H06380, KAKENHI-PROJECT-18H04088, KAKENHI-PROJECT-18H02027, KAKENHI-PROJECT-19H03124, KAKENHI-PROJECT-18K15655
[Journal Article] Histological scoring system for subchondral bone changes in murine models of joint aging and osteoarthritis2020
- Author(s)
  Nagira Keita, Ikuta Yasunari, Shinohara Masahiro, Sanada Yohei, Omoto Takenori, Kanaya Haruhisa, Nakasa Tomoyuki, Ishikawa Masakazu, Adachi Nobuo, Miyaki Shigeru, Lotz Martin
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 10077-10077
- DOI
  10.1038/s41598-020-66979-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16223, KAKENHI-PROJECT-19H03785, KAKENHI-PROJECT-19H03991, KAKENHI-PROJECT-18KT0018
[Journal Article] Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-κB activity.2019
- Author(s)
  Miyazaki T, Zhao Z, Ichihara Y, Yoshino D, Imamura T, Sawada K, Hayano S, Kamioka H, Mori S, Hirata H, Araki K, Kawauchi K, Shigemoto K, Tanaka S, Bonewald LF, Honda H, Shinohara M, Nagao M, Ogata T, Harada I, Sawada Y
- Journal Title
  
  Sci Adv
  
  Volume: 5 Issue: 9 Pages: 7802-7802
- DOI
  10.1126/sciadv.aau7802
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KT0018, KAKENHI-PROJECT-17K07185, KAKENHI-PROJECT-19K10381, KAKENHI-PROJECT-19K11660, KAKENHI-PUBLICLY-18H04970, KAKENHI-PROJECT-18H04088, KAKENHI-PROJECT-19H03991, KAKENHI-PROJECT-19H04064, KAKENHI-PROJECT-17K09151
[Journal Article] 宇宙における骨量低下と破骨細胞2017
- Author(s)
  篠原正浩
- Journal Title
  
  腎と骨代謝　特集「宇宙医学研究の最前線」
  
  Volume: 30 Pages: 195-202
- Data Source
  KAKENHI-PUBLICLY-16H01634
[Journal Article] Development of new experimental platform ‘MARS’―Multiple Artificial-gravity Research System―to elucidate the impacts of micro/partial gravity on mice.2017
- Author(s)
  Shiba D, Mizuno H, Yumoto A, Shimomura M, Kobayashi H, Morita H, Shimbo M, Hamada M, Kudo T, Shinohara M, Asahara H, Shirakawa M, Takahashi S
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 10837-10837
- DOI
  10.1038/s41598-017-10998-4
- NAID
  120007017303
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01634, KAKENHI-PROJECT-15K11916
[Journal Article] Mohawk transcription factor regulates homeostasis of the periodontal ligament2017
- Author(s)
  Koda N, Sato T, Shinohara M, Ichinose S, Ito Y, Nakamichi R, Kayama T, Kataoka K, Suzuki H, Moriyama K, Asahara H
- Journal Title
  
  Development
  
  Volume: 144 Pages: 313-320
- DOI
  10.1242/dev.135798
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01634, KAKENHI-PLANNED-26113008, KAKENHI-PROJECT-25305037, KAKENHI-PROJECT-15K15544, KAKENHI-PROJECT-17K16706, KAKENHI-PROJECT-17K17313, KAKENHI-PROJECT-15H02560, KAKENHI-PROJECT-15K15540
[Journal Article] Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K2017
- Author(s)
  Ohmae S, Noma N, Toyomoto M, Shinohara M, Takeiri M, Fuji H, Takemoto K, Iwaisako K, Fujita T, Takeda N, Kawatani M, Aoyama M, Hagiwara M, Ishihama Y, Asagiri M
- Journal Title
  
  Sci Rep
  
  Volume: - Issue: 1 Pages: 41710-41710
- DOI
  10.1038/srep41710
- NAID
  120006313626
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01634, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-14J06672, KAKENHI-PROJECT-26461909, KAKENHI-PROJECT-16K01941, KAKENHI-PROJECT-16K10101, KAKENHI-PROJECT-15K15540
[Journal Article] Osteoimmunology: The Conceptual Framework Unifying the Immune and Skeletal Systems2017
- Author(s)
  Okamoto Kazuo、Nakashima Tomoki、Shinohara Masahiro、Negishi-Koga Takako、Komatsu Noriko、Terashima Asuka、Sawa Shinichiro、Nitta Takeshi、Takayanagi Hiroshi
- Journal Title
  
  Physiological Reviews
  
  Volume: 97 Issue: 4 Pages: 1295-1349
- DOI
  10.1152/physrev.00036.2016
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19582, KAKENHI-PUBLICLY-16H01634, KAKENHI-PROJECT-16H05202, KAKENHI-PROJECT-16H05506, KAKENHI-PROJECT-17H04050, KAKENHI-PROJECT-15H05653, KAKENHI-PROJECT-15F15414, KAKENHI-PROJECT-16K14648, KAKENHI-PROJECT-15H05703, KAKENHI-PROJECT-16K15252, KAKENHI-PROJECT-26713015, KAKENHI-PROJECT-15K15149
[Journal Article] Gene targeting of the transcription factor Mohawk in rats causes heterotropic ossification of Achilles tendon via failed tenogenesis2016
- Author(s)
  Suzuki H, Ito Y, Shinohara M, Yamashita S, Ichinose S, Kishida A, Oyaizu T, Kayama T, Nakamichi R, Koda N, Yagishita K, Lotz MK, Okawa A, Asahara H
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 113 Issue: 28 Pages: 7840-7845
- DOI
  10.1073/pnas.1522054113
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01634, KAKENHI-PLANNED-26113008, KAKENHI-PROJECT-16K20037, KAKENHI-PROJECT-15K15544, KAKENHI-INTERNATIONAL-15K21720, KAKENHI-PROJECT-15H02560, KAKENHI-PROJECT-15K15540
[Journal Article] Ground-based assessment of JAXA mouse habitat cage unit by mouse phenotypic studies2016
- Author(s)
  Shimbo M, Kudo T, Hamada M, Jeon H, Imamura Y, Asano K, Okada R, Tsunakawa Y, Mizuno S, Yagami K, Ishikawa C, Li H, Shiga T, Ishida J, Hamada J, Murata K, Ishimaru T, Hashimoto M, Fukamizu A, Yamane M, Ikawa M, Morita H, Shinohara M, et al.
- Journal Title
  
  Exp Anim
  
  Volume: 65 Pages: 175-187
- NAID
  130005152402
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H01634
[Journal Article] Phosphoproteomic analysis of kinase-deficient mice reveals multiple TAK1 targets in osteoclast differentiation.2015
- Author(s)
  Sumiya E, Negishi-Koga T, Nagai Y, Suematsu A, Suda T, Shinohara M, Sato K, Sanjo H, Akira S, Takayanagi H.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 463 Issue: 4 Pages: 1284-90
- DOI
  10.1016/j.bbrc.2015.06.105
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10488, KAKENHI-PROJECT-15K15540, KAKENHI-PROJECT-26860183, KAKENHI-PROJECT-13J40074, KAKENHI-PROJECT-15H05703
[Journal Article] Hypergravity provokes a temporary reduction in CD4+CD8+ thymocyte number and a persistent decrease in medullary thymic epithelial cell frequency in mice.2015
- Author(s)
  Tateishi R, Akiyama N, Miyauchi M, Yoshinaga R, Sasanuma H, Kudo T, Shimbo M, Shinohara M, Obata K, Inoue J, Shirakawa M, Shiba D, Asahara H, Yoshida N, Takahashi S, Morita H, Akiyama T
- Journal Title
  
  PLOS ONE
  
  Volume: 10 Issue: 10 Pages: 1-17
- DOI
  10.1371/journal.pone.0141650
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15540, KAKENHI-INTERNATIONAL-15K21745, KAKENHI-PUBLICLY-15H01150, KAKENHI-PUBLICLY-15H01176, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05940, KAKENHI-PROJECT-25460283, KAKENHI-PROJECT-26670234, KAKENHI-PROJECT-26290036
[Journal Article] 炎症性関節炎における破骨細胞の制御2013
- Author(s)
  篠原正浩、高柳広
- Journal Title
  
  臨床リウマチ
  
  Volume: 25
- NAID
  130005094929
- Data Source
  KAKENHI-PROJECT-23659149
[Journal Article] 炎症性関節炎における破骨細胞の制御2013
- Author(s)
  篠原正浩、高柳広
- Journal Title
  
  臨床リウマチ
  
  Volume: 25
- NAID
  130005094929
- Data Source
  KAKENHI-PROJECT-22689048
[Journal Article] TREM2 and β-Catenin Regulate Bone Homeostasis by Controlling the Rate of Osteoclastogenesis.2012
- Author(s)
  Otero K#, Shinohara M#, Zhao H#, Cella M, Gilfillan S, Colucci A, Faccio R, Ross FP, Teitelbaum SL, Takayanagi H, Colonna M.
- Journal Title
  
  J Immunol
  
  Volume: 188 Pages: 2612-2621
- Data Source
  KAKENHI-PROJECT-22689048
[Journal Article] Inhibitory effect of chloroquine on bone resorption reveals the essential role of lysosomes in osteoclast differentiation and function2012
- Author(s)
  Al-Bari A, Shinohara M, Nagai Y, Takayanagi H
- Journal Title
  
  Inflamma Regener
  
  Volume: 32 Pages: 222-231
- Data Source
  KAKENHI-PROJECT-22689048
[Journal Article] TREM2 and ss-Catenin Regulate Bone Homeostasis by Controlling the Rate of Osteoclastogenesis2012
- Author(s)
  Otero K*, Shinohara M*, Zhao H*, Cella M, Gilfillan S, Colucci A, Faccio R, Ross FP, Teitelbaum SL, Takayanagi H, Colonna M, *equal contributor
- Journal Title
  
  Journal of Immunology
  
  Volume: 188 Issue: 6 Pages: 2612-2621
- DOI
  10.4049/jimmunol.1102836
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689048, KAKENHI-PROJECT-23659149
[Journal Article] TREM2 and -Catenin Regulate Bone Homeostasis by Controlling the Rate of Osteoclastogenesis2012
- Author(s)
  Otero K#, Shinohara M#, Zhao H#, Cella M, Gilfillan S, Colucci A, Faccio R, Ross FP, Teitelbaum SL, Takayanagi H, Colonna M
- Journal Title
  
  J Immunol
  
  Volume: 188 Pages: 2612-2621
- Data Source
  KAKENHI-PROJECT-23659149
[Journal Article] Class IA Phosphatidylinositol 3-kinases regulates osteoclastic bone resorption through Akt-mediated vesicle transport in mice2012
- Author(s)
  Shinohara M, Nakamura M, Masuda H, Kadono Y, Iwasawa M, Nagase Y, Ueki K, Kadowaki T, Sasaki T, Kato S, Nakamura H, Nakamura K, Tanaka S, Takayanagi H
- Journal Title
  
  J Bone Miner Res
  
  Volume: 27 Pages: 2464-2475
- Data Source
  KAKENHI-PROJECT-22689048
[Journal Article] Inhibitory effect of chloroquine on bone resorption reveals the essential role of lysosomes in osteoclast differentiation and function2012
- Author(s)
  Al-Bari A, Shinohara M, Nagai Y, Takayanagi H
- Journal Title
  
  Inflamma Regener
  
  Volume: 32 Pages: 222-231
- Data Source
  KAKENHI-PROJECT-23659149
[Journal Article] Class IA Phosphatidylinositol 3-kinases regulates osteoclastic bone resorption through Akt-mediated vesicle transport in mice2012
- Author(s)
  Shinohara M, Nakamura M, Masuda H, Kadono Y, Iwasawa M, Nagase Y, Ueki K, Kadowaki T, Sasaki T, Kato S, Nakamura H, Nakamura K, Tanaka S, Takayanagi H
- Journal Title
  
  J Bone Miner Res
  
  Volume: 27 Pages: 2464-2475
- Data Source
  KAKENHI-PROJECT-23659149
[Journal Article] Suppression of bone formation by osteoclastic expression of semaphorin 4D2011
- Author(s)
  Negishi-Koga T, Shinohara M, Komatsu N, Bito H, Kodama T, Friedel RH, Takayanagi H
- Journal Title
  
  Nat Med
  
  Volume: 17 Pages: 1473-1480
- Data Source
  KAKENHI-PROJECT-23659149
[Journal Article] Suppression of bone formation by osteoclastic expression of semaphorin 4D.2011
- Author(s)
  Negishi-Koga T, Shinohara M, Komatsu N, Bito H, Kodama T, Friedel RH, Takayanagi H
- Journal Title
  
  Nat Med
  
  Volume: 17 Pages: 1473-1480
- Data Source
  KAKENHI-PROJECT-22689048
[Journal Article] Suppression of bone formation by osteoclastic expression of semaphorin 4D2011
- Author(s)
  Negishi-Koga T, Shinohara M, Komatsu N, Bito H, Kodama T, Friedel RH, Takayanagi H
- Journal Title
  
  Nature Medicine
  
  Volume: 17 Issue: 11 Pages: 1473-1480
- DOI
  10.1038/nm.2489
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20670002, KAKENHI-PROJECT-22689048, KAKENHI-PROJECT-23659149
[Journal Article] 破骨細胞分化を司る免疫制御分子ネットワーク2009
- Author(s)
  篠原正浩
- Journal Title
  
  実験医学 27
  
  Pages: 852-859
- Data Source
  KAKENHI-PROJECT-17GS0313
[Journal Article] Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.2008
- Author(s)
  Shinohara, M., et. al.
- Journal Title
  
  Cell 132
  
  Pages: 794-806
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17GS0313
[Journal Article] Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.2008
- Author(s)
  Shinohara, M.
- Journal Title
  
  Cell 132
  
  Pages: 794-806
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17GS0313
[Journal Article] Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.2008
- Author(s)
  Shinohara M, Koga T, Okamoto K, Sakaguchi S, Arai K, Yasuda H, Takai T, Kodama T, Morio T, Geha RS, Kitamura D, Kurosaki T, Ellmeier W, Takayanagi H.
- Journal Title
  
  CELL 132
  
  Pages: 794-806
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390410
[Journal Article] Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals2008
- Author(s)
  Shinohara M, Koga T, Okamoto K, Sakaguchi S, Arai K, Yasuda H, Takai T, Kodama T, Morio T, Geha RS, Kitamura D, Kurosaki T, Ellmeier W, Takayanagi H.
- Journal Title
  
  CELL Volume: 132 Issue: 5
  
  Pages: 794-806
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390410
[Journal Article] 破骨細胞形成のメカニズム-新たな骨破壊疾患治療法の可能性2008
- Author(s)
  篠原正浩
- Journal Title
  
  DENTAL DIAMOND 33
  
  Pages: 68-71
- Data Source
  KAKENHI-PROJECT-17GS0313
[Journal Article] Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals2008
- Author(s)
  Shinohara, M., Koga, T., Okamoto, K., Sakaguchi, S., Arai, K., Yasuda, H., Takai, T., Kodama, T., Morio, T., Geha, R. S., Kitamura, D., Kurosaki, T., Ellmeier, W., Takayanagi, H.
- Journal Title
  
  Cell 132
  
  Pages: 794-806
- Data Source
  KAKENHI-PROJECT-17GS0313
[Journal Article] Novel osteoclast signaling mechanisms.2007
- Author(s)
  Shinohara M, Takayanagi H.
- Journal Title
  
  Curr Osteoporos Rep 5
  
  Pages: 67-72
- Data Source
  KAKENHI-PROJECT-17GS0313
[Journal Article] Pathological role of osteoclast costimulation in arthritis-induced bone loss.2007
- Author(s)
  Ochi S, Shinohara M, Sato K, Gober HJ, Koga T, Kodama T, Takai T, Miyasaka N, Takayanagi H.
- Journal Title
  
  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104
  
  Pages: 11394-11399
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390410
[Journal Article] Noxl redox signaling mediates oncogenic Ras-induced disruption of stress fibers and focal adhesions by down-regulating Rho.2007
- Author(s)
  Shinohara M, Shang WH, Kubodera M, Harada S, Mitsushita J, Kato M, Miyazaki H, Sumimoto H, Kamata T.
- Journal Title
  
  JOURNAL OF BIOLOGICAL CHEMISTRY 282
  
  Pages: 17640-17648
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390410
[Journal Article] Pathological role of osteoclast costimulation in arthritis-induced bone loss2007
- Author(s)
  Ochi S, Shinohara M, Sato K, Gober HJ, Koga T, Kodama T, Takai T, Miyasaka N, Takayanagi H.
- Journal Title
  
  Proc Natl Acad Sci USA. Volume: 104 Issue: 27
  
  Pages: 11394-11399
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390410
[Journal Article] Nox1 redox signaling mediates oncogenic Ras-induced disruption of stress fibers and focal adhesions by down-regulating Rho2007
- Author(s)
  Shinohara M, Shang WH, Kubodera M, Harada S, Mitsushita J, Kato M, Miyazaki H, Sumimoto H, Kamata T.
- Journal Title
  
  JOURNAL OF BIOLOGICAL CHEMISTRY Volume: 282 Issue: 24
  
  Pages: 17640-17648
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390410
[Journal Article] Pathological role of osteoclast costimulation in arthritis-induced bone loss2007
- Author(s)
  Ochi, S., Shinohara, M., Sato, K., Gober H. J., Koga, T., Kodama, T., Takai T., Miyasaka N., Takayanagi H.
- Journal Title
  
  Proc Natl Acad Sci USA 104
  
  Pages: 11394-11399
- Data Source
  KAKENHI-PROJECT-17GS0313
[Journal Article] Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program2006
- Author(s)
  Negishi H, Fujita Y, Yanai H, Sakaguchi S, Ouyang X, Shinohara M, Takayanagi H, Ohba Y, Taniguchi T, Honda K.
- Journal Title
  
  Proc Natl Acad Sci USA Volume: 103 Issue: 41
  
  Pages: 15136-15141
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390410
[Journal Article] Evidence for licensing of IFN-γ-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program.2006
- Author(s)
  Negishi, H, Fujita, Y, Yanai, H, Sakaguchi, S, Ouyang, X, Shinohara, M, Takayanagi, H, Ohba, Y, Taniguchi, T, Honda, K.
- Journal Title
  
  Proc Natl Acad Sci 103・41
  
  Pages: 15136-41
- Data Source
  KAKENHI-PROJECT-17GS0313
[Journal Article] Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toil-like receptor-dependent gene induction program2006
- Author(s)
  Negishi H, Fujita Y, Yanai H, Sakaguchi S, Ouyang X, Shinohara M, Takayanagi H, Ohba Y, Taniguchi T, Honda K.
- Journal Title
  
  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 103
  
  Pages: 15136-15141
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390410
[Presentation] 運動による健康維持・増進の分子基盤2023
- Author(s)
  澤田泰宏、﨑谷直義、村瀬修平、高野弘二、篠原正浩
- Organizer
  第10回日本サルコペニア・フレイル学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-21H04866
[Presentation] 運動で頭部に生じる衝撃は、頭側延髄腹外側野の間質液流動の促進を介して、アストロサイトの機能を制御し、高血圧を改善する2023
- Author(s)
  﨑谷直義,前川貴郊,岸拓弥,篠原啓介,吉野大輔,高野弘二,郷地慶,越智広樹,篠原正浩,澤田泰宏
- Organizer
  第59回高血圧関連疾患モデル学会学術総会
- Data Source
  KAKENHI-PROJECT-21H04866
[Presentation] 脳へのメカニカルストレスは高血圧を改善する2023
- Author(s)
  澤田泰宏、﨑谷直義、村瀬修平、高野弘二、篠原正浩
- Organizer
  第41回日本骨代謝学会
- Invited
- Data Source
  KAKENHI-PROJECT-21H04866
[Presentation] Brain-targeted Mechanical Intervention with Passive Head Motion Can Have an Antihypertensive Effect2022
- Author(s)
  Yasuhiro Sawada, Naoyoshi Sakitani, Takahiro Maekawa, Daisuke Yoshino, Kouji Takano, Takuya Kishi, Keisuke Shinohara, Ayumu Konno, Hirokazu Hirai, Takamasa Sakai, Kohzoh Yoshino, Motoshi Nagao, Masahiro Shinohara
- Organizer
  Gordon Research Conferences: Angiotensin
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04866
[Presentation] Brain-Targeted Mechanical Intervention Using Passive Head Motion Can Have an Antihypertensive Effect2022
- Author(s)
  Yasuhiro SAWADA, Naoyoshi SAKITANI, Takuya KISHI, Keisuke SHINOHARA, Hirotsugu TSUCHIMOCHI
- Organizer
  American Heart Association Scientific Sessions 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04866
[Presentation] 障害者の骨をどう守る？2020
- Author(s)
  篠原正浩
- Organizer
  第4回理論免疫学ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-18KT0018
[Presentation] 障害者の骨をどう守る?2020
- Author(s)
  篠原正浩
- Organizer
  第4回理論免疫学ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-19H03991
[Presentation] 障害者の骨をどう守る?2020
- Author(s)
  篠原正浩
- Organizer
  第4回理論免疫学ワークショップ
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04970
[Presentation] MCTOモデルマウスは患者と同様の腎症を示す2019
- Author(s)
  綱川祐貴、篠原正浩、濱田理人、松永友里菜、布施谷清香、全考静、脇本悠史、臼井俊明、金井真帆、水野聖哉、森戸直記、高橋智
- Organizer
  第5回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-19H03991
[Presentation] 多中心性手根骨足根骨融解症の病態理解のための分子的基盤-遺伝子欠損から疾患変異へ-2019
- Author(s)
  綱川祐貴、篠原正浩,、濱田理人、全孝静、水野聖哉、Andreas Zankl 、臼井俊明、布施谷清香、金井真帆、森戸直記、高橋智
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H03991
[Presentation] 変形性膝関節症マウスモデルを用いた軟骨下骨の組織学的スコアリングシステムの確立2019
- Author(s)
  柳樂慶太、真田洋平、篠原正浩、萩野浩、味八木茂
- Organizer
  第37回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-18KT0018
[Presentation] 多中心性手根骨足根骨融解症の病態理解のための分子的基盤-遺伝子欠損から疾患変異へ-2019
- Author(s)
  綱川祐貴、篠原正浩,、濱田理人、全孝静、水野聖哉、Andreas Zankl 、臼井俊明、布施谷清香、金井真帆、森戸直記、高橋智
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18KT0018
[Presentation] 変形性膝関節症マウスモデルを用いた軟骨下骨の組織学的スコアリングシステムの確立2019
- Author(s)
  柳樂慶太、味八木茂、生田祥也、眞田洋平、篠原正浩、安達伸生、永島英樹、Lotz Martin
- Organizer
  第34回日本整形外科基礎学会
- Data Source
  KAKENHI-PROJECT-18KT0018
[Presentation] 変形性関節症マウスモデルを用いたひざ関節周囲骨の組織学的スコアリングシステムの確立2019
- Author(s)
  柳楽慶太、生田祥也、篠原正浩、中佐智幸、眞田洋平、大本武児、安達伸生、味八木茂、Martin Lotz
- Organizer
  第32回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-18KT0018
[Presentation] MCTOモデルマウスは患者と同様の腎症を示す2019
- Author(s)
  綱川祐貴、篠原正浩、濱田理人、松永友里菜、布施谷清香、全考静、脇本悠史、臼井俊明、金井真帆、水野聖哉、森戸直記、高橋智
- Organizer
  第5回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-18KT0018
[Presentation] 力学的荷重による骨代謝制御2018
- Author(s)
  篠原正浩
- Organizer
  第2回理論免疫ワークショップ
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01634
[Presentation] Osteoporosis in spaceflight and osteoclasts2018
- Author(s)
  Shinohara M
- Organizer
  第９５回日本生理学会大会シンポジウム
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01634
[Presentation] Systems bone biology -骨の包括的理解から疾患制御へ-2017
- Author(s)
  岩波翔也、中岡慎二、野下浩司、岩見真吾、篠原正浩
- Organizer
  第3回日本骨免疫学会
- Data Source
  KAKENHI-PUBLICLY-16H01634
[Presentation] 関節リウマチ骨破壊と骨免疫学2017
- Author(s)
  篠原正浩
- Organizer
  理論免疫ワークショップ
- Place of Presentation
  広島
- Year and Date
  2017-01-19
- Invited
- Data Source
  KAKENHI-PROJECT-15K15540
[Presentation] 長期宇宙滞在マウスの骨組織解析2017
- Author(s)
  篠原正浩、工藤崇、新保未来、芝大、白川正輝、高橋智、浅原弘嗣
- Organizer
  第3回日本骨免疫学会
- Data Source
  KAKENHI-PUBLICLY-16H01634
[Presentation] 長期宇宙滞在マウスの骨組織解析2017
- Author(s)
  篠原正浩、鈴木碧、工藤崇、新保未来、芝大、白川正輝、高橋智、浅原弘嗣
- Organizer
  第4回日本リウマチ学会ベーシックリサーチカンファレンス
- Data Source
  KAKENHI-PUBLICLY-16H01634
[Presentation] 長期宇宙滞在マウスの骨組織解析2017
- Author(s)
  篠原正浩、工藤崇、新保未来、芝大、白川正輝、高橋智、浅原弘嗣
- Organizer
  第35回日本骨代謝学会
- Data Source
  KAKENHI-PUBLICLY-16H01634
[Presentation] 関節リウマチ骨破壊と骨免疫学2017
- Author(s)
  篠原正浩
- Organizer
  理論免疫ワークショップ
- Place of Presentation
  広島
- Year and Date
  2017-01-19
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01634
[Presentation] Roles of transcription factor Mohawk in periodontal ligament2016
- Author(s)
  Koda N, Shinohara M, et al.
- Organizer
  International Association for Dental Research 2016
- Place of Presentation
  Seoul, Korea
- Year and Date
  2016-06-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15540
[Presentation] ROLES OF TRANSCRIPTIONAL FACTOR MOHAWK IN PERIODONTAL LIGAMENT2016
- Author(s)
  Naoki Koda, Masahiro Shinohara, Shizuko Ichinose, Yoshiaki Ito, Ryo Nakamichi, Tomohiro Kayama, Keiji Moriyama, Hiroshi Asahara
- Organizer
  IBMS Herbert Fleisch Workshop
- Place of Presentation
  Brugge (Belgium))
- Year and Date
  2016-02-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15540
[Presentation] Roles of transcription factor Mohawk in periodontal ligament2016
- Author(s)
  Koda N, Shinohara M, et al.
- Organizer
  International Association for Dental Research 2016
- Place of Presentation
  Seoul, Korea
- Year and Date
  2016-06-21
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01634
[Presentation] 骨保護から寝たきりを防ぐ統合的研究2016
- Author(s)
  篠原正浩
- Organizer
  数学協働プログラムスタディグループ
- Place of Presentation
  松山
- Year and Date
  2016-08-16
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01634
[Presentation] IA型PI3Kを介した骨細胞による骨芽細胞制御2016
- Author(s)
  篠原正浩、中浜健一、浅原弘嗣
- Organizer
  第2回日本骨免疫学会
- Place of Presentation
  沖縄
- Year and Date
  2016-07-06
- Data Source
  KAKENHI-PROJECT-15K15540
[Presentation] 骨保護から寝たきりを防ぐ統合的研究2016
- Author(s)
  篠原正浩
- Organizer
  数学協働プログラムスタディグループ
- Place of Presentation
  松山
- Year and Date
  2016-08-16
- Invited
- Data Source
  KAKENHI-PROJECT-15K15540
[Presentation] 力学的荷重変動による骨代謝恒常性維持の新たなメカニズムの解明2015
- Author(s)
  篠原正浩、工藤崇、新保未来、芝大、白川正輝、森田啓之、高橋智、浅原弘嗣
- Organizer
  日本骨免疫学会
- Place of Presentation
  ホテルブリーズベイマリーナ（沖縄県宮古島市）
- Year and Date
  2015-06-30
- Data Source
  KAKENHI-PROJECT-15K15540
[Presentation] 歯根膜における転写因子 Mkx の機能解析2015
- Author(s)
  幸田直己、篠原正浩、市野瀬志津子、森山啓司、浅原弘嗣
- Organizer
  日本骨代謝学会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-07-23
- Data Source
  KAKENHI-PROJECT-15K15540
[Presentation] ROLES OF TRANSCRIPTIONAL FACTOR MOHAWK IN PERIODONTAL LIGAMENT.2015
- Author(s)
  Naoki Koda, Masahiro Shinohara, Ryo Nakamichi, Yoshiaki Ito, Shizuko Ichinose, Keiji Moriyama, Hiroshi Asahara
- Organizer
  25th Annual Scientific meeting of the Australian and New Zealand Bone and Mineral Society
- Place of Presentation
  Tasmania (Australia)
- Year and Date
  2015-11-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15540
[Presentation] 歯根膜恒常性維持の新たなメカニズム - 転写因子Mohawk homeobox ( Mkx ) の機能解明2015
- Author(s)
  幸田直己、篠原正浩、伊藤義晃、市野瀬志津子、森山啓司、浅原弘嗣
- Organizer
  日本分子生物学会年会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K15540
[Presentation] 歯根膜恒常性維持の新たなメカニズム - 転写因子Mkxの機能解明2015
- Author(s)
  幸田直己、森山啓司、篠原正浩、浅原弘嗣
- Organizer
  日本矯正歯科学会大会
- Place of Presentation
  福岡国際会議場（福岡県博多市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K15540
[Presentation] 歯根膜における転写因子 Mkx の機能解析2015
- Author(s)
  幸田直己、篠原正浩、伊藤義晃、市野瀬志津子、森山啓司、浅原弘嗣
- Organizer
  日本骨免疫学会
- Place of Presentation
  ホテルブリーズベイマリーナ（沖縄県宮古島市）
- Year and Date
  2015-06-30
- Data Source
  KAKENHI-PROJECT-15K15540
[Presentation] リソソームの酸性化は破骨細胞分化に必要である2012
- Author(s)
  永井裕介、篠原正浩、Al-Bari Md. Adbul Alim、高柳広
- Organizer
  第30回日本骨代謝学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23659149
[Presentation] クロロキンによる破骨細胞分化抑制2012
- Author(s)
  永井裕介、篠原正浩、高柳広
- Organizer
  第33回日本炎症再生医学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23659149
[Presentation] リソソームの酸性化は破骨細胞分化に必要である2012
- Author(s)
  永井裕介、篠原正浩、Al-BariMd.AdbulAlim、高柳広
- Organizer
  第30回日本骨代謝学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22689048
[Presentation] クロロキンによる破骨細胞分化抑制2012
- Author(s)
  永井裕介、篠原正浩、高柳広
- Organizer
  第33回日本炎症・再生医学会
- Place of Presentation
  博多
- Data Source
  KAKENHI-PROJECT-22689048
[Presentation] クロロキンによる破骨細胞分化抑制2012
- Author(s)
  永井裕介、篠原正浩、高柳広
- Organizer
  第33回日本炎症・再生医学会
- Place of Presentation
  博多
- Data Source
  KAKENHI-PROJECT-23659149
[Presentation] 骨破壊抑制を目指す破骨細胞研究2012
- Author(s)
  篠原正浩
- Organizer
  第33回日本炎症再生医学会
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-23659149
[Presentation] 骨破壊抑制を目指す破骨細胞研究2012
- Author(s)
  篠原正浩
- Organizer
  第３３回日本炎症再生医学会
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-22689048
[Presentation] リソソームの酸性化は破骨細胞分化に必要である2012
- Author(s)
  永井裕介、篠原正浩、高柳広
- Organizer
  第３０回日本骨代謝学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22689048
[Presentation] クロロキンによる破骨細胞分化抑制2012
- Author(s)
  永井裕介、篠原正浩、高柳広
- Organizer
  第３３回日本炎症再生医学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22689048
[Presentation] Lysosomal function associated with osteoclast differentiation2011
- Author(s)
  Al-Bari MD. Adlum Alim、篠原正浩、高柳広
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22689048
[Presentation] The role of classIA PI3K in osteoclasts2011
- Author(s)
  Shinohara M, Tanaka S, Takayanagi H
- Organizer
  33th Annual Meeting of the American Society for Bone and Mineral Research
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23659149
[Presentation] Protection of bone loss by targeting semaphorin 4D expressed by osteoclasts2011
- Author(s)
  Negishi-Koga T, Shinohara M, Takayanagi H
- Organizer
  33^<th> Annual Meeting of the American Society for Bone and Mineral Research
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-22689048
[Presentation] Suppression of bone formation by an axon guidance protein, semaphorin4D2011
- Author(s)
  古賀貴子、篠原正浩、高柳広
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22689048
[Presentation] Lysosomal function associated with osteoclast differentiation2011
- Author(s)
  Al-Bari MD. Abdul Alim、篠原正浩、高柳広
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23659149
[Presentation] Suppression of bone formation by an axon guidance protein, semaphorin4D2011
- Author(s)
  古賀貴子、篠原正浩、高柳広
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23659149
[Presentation] Suppression of bone formation by an axon guidance protein, semaphorin 4D2011
- Author(s)
  古賀貴子、篠原正浩、高柳広
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22689048
[Presentation] Protection of bone loss bytargeting semaphorin 4D expressed by osteoclasts2011
- Author(s)
  Negishi-Koga T, Shinohara M, Takayanagi H
- Organizer
  33th Annual Meeting of the American Society for Bone and Mineral Research
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23659149
[Presentation] セマフォリン4Dを介した破骨細胞による骨形成抑制制御2011
- Author(s)
  古賀貴子、篠原正浩、高柳広
- Organizer
  第28回日本骨代謝学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23659149
[Presentation] Protection of bone loss by targeting semaphorin 4D expressed by osteoclasts2011
- Author(s)
  Negishi-Koga T, Shinohara M, Takayanagi H
- Organizer
  33th Annual Meeting of the American Society for Bone and MineralResearch
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-22689048
[Presentation] Suppression of bone formation by an axon guidance protein, semaphorin4D2011
- Author(s)
  古賀　貴子、篠原　正浩、高柳　広
- Organizer
  第３４回日本分子生物学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23659149
[Presentation] The role of classIA PI3K in osteoclasts2011
- Author(s)
  Shinohara M, Tanaka S, Takayanagi H
- Organizer
  33th Annual Meeting of the American Society for Bone and Mineral Research
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-22689048
[Presentation] セマフォリン4Dを介した破骨細胞による骨形成抑制制御2011
- Author(s)
  古賀貴子、篠原正浩、高柳広
- Organizer
  第28回日本骨代謝学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22689048
[Presentation] The role of classIA PI3K in osteoclasts2011
- Author(s)
  Shinohara M, Tanaka S, Takayanagi H
- Organizer
  33^<th> Annual Meeting of the American Society for Bone and Mineral Research
- Place of Presentation
  San Diego, USA
- Year and Date
  2011-09-18
- Data Source
  KAKENHI-PROJECT-22689048
[Presentation] Lysosomal function associated with osteoclast differentiation2011
- Author(s)
  Al-Bari MD. Adlum Alim、篠原　正浩、高柳　広
- Organizer
  第３４回日本分子生物学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23659149
[Presentation] Protection of bone loss by targeting semaphorin 4D expressed by osteoclasts2011
- Author(s)
  Negishi-Koga T, Shinohara M, Takayanagi H
- Organizer
  33th Annual Meeting of the American Society for Bone and Mineral Research
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23659149
[Presentation] セマフォリン４Ｄを介した破骨細胞による骨形成抑制制御2011
- Author(s)
  古賀　貴子、篠原　正浩、高柳　広
- Organizer
  第２８回日本骨代謝学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23659149
[Presentation] 破骨細胞の分化・機能を制御するシグナル伝達経路2010
- Author(s)
  篠原正浩、高柳広
- Organizer
  高遠シンポジウム
- Place of Presentation
  長野県高遠町
- Data Source
  KAKENHI-PROJECT-22689048
[Presentation] 破骨細胞を制御する分子群-シグナル伝達システムの理解と治療標的の探索-2010
- Author(s)
  篠原正浩
- Organizer
  第54回日本リウマチ学会学術集会
- Place of Presentation
  神戸
- Year and Date
  2010-04-24
- Data Source
  KAKENHI-PROJECT-22689048
[Presentation] PI3K-Akt経路はPlekhm1のリン酸化を介して破骨細胞の骨吸収を制御する2010
- Author(s)
  篠原正浩、永井裕介、中村正樹、田中栄、高柳広
- Organizer
  第33回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22689048
[Presentation] Tyrosine kinases Btk and Tec are essential for osteoclast differentiation2008
- Author(s)
  Shinohara M., et al.
- Organizer
  The 13th Asia Pacific League of Associations for Rheumatology Congress
- Place of Presentation
  Yokohama
- Year and Date
  2008-09-25
- Data Source
  KAKENHI-PROJECT-17GS0313
[Presentation] Tecファミリーキナーゼによる破骨細胞分化制御機構(The role of Tec family kinases in osteoclast differentiation)2008
- Author(s)
  篠原正浩, 他
- Organizer
  第52回日本リウマチ学会総会・学術集会ワークショップ32「骨代謝と骨粗鬆症」
- Place of Presentation
  札幌
- Year and Date
  2008-04-23
- Data Source
  KAKENHI-PROJECT-17GS0313
[Presentation] Tec Kinases, Therapeutic Targets for Bone Destructive Diseases.2008
- Author(s)
  Shinohara M., et al.
- Organizer
  The 30th Annual Meeting of the American Society for Bone and Mineral Research.
- Place of Presentation
  Montreal, Canada
- Data Source
  KAKENHI-PROJECT-17GS0313
[Presentation] 免疫不全と骨代謝-Tecファミリーチロシンキナーゼによる破骨細胞分化制御-2008
- Author(s)
  篠原正浩, 他
- Organizer
  第29回日本炎症・再生医学会
- Place of Presentation
  東京
- Year and Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-17GS0313
[Presentation] The role of Tec family kinases in osteoclast differentiation2008
- Author(s)
  Shinohara M., et al.
- Organizer
  2^<nd> International Conference on Osteoimmunology: Interactions of the Immune and Skeletal Systems
- Place of Presentation
  Rhodos, Greece
- Year and Date
  2008-06-13
- Data Source
  KAKENHI-PROJECT-17GS0313
[Presentation] Tecキナーゼファミリーによる破骨細胞分化制御機構2007
- Author(s)
  篠原正浩, 他
- Organizer
  第25回日本骨代謝学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2007-07-21
- Data Source
  KAKENHI-PROJECT-17GS0313
[Presentation] Tec Tyrosine Kinases Are Essential For Osteoclast Differentiation.2007
- Author(s)
  Shinohara, M. et. al
- Organizer
  The 29th Annual Meeting of the American Society for Bone and Mineral Research.
- Place of Presentation
  Honolulu, U.S.A.
- Year and Date
  2007-09-19
- Data Source
  KAKENHI-PROJECT-17GS0313

1. Sawada Yasuhiro (50313135)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
2. 中浜健一 (60281515)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. ADACHI Yoshifumi (50201893)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KAMATA Tohru (40056304)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TAKAYANAGI Hiroshi (20334229)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
6. NAKASHIMA Tomoki (00346959)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. ASAGIRI Masataka (20372435)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. SATO Kojiro (10372434)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
9. 吉野大輔 (80624816)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
10. 崎谷直義 (30824859)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
11. 斎田俊明 (10010381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 春宮覚 (50301792)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 古賀貴子 (90451905)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. 味八木茂 (10392490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
15. 岩見真吾 (90518119)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 野下浩司 (10758494)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 今村武史 (00552093)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 齋藤琢 (30456107)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. 原田伊知郎 (00361759)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 木野久志 (10633406)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 高野晴子 (40532891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
22. 住谷瑛理子 (50724754)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 迫圭輔 (50786291)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 青木吉嗣 (80534172)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. KODA Naoki

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
26. 冨田拓郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 眞田洋平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 前川貴郊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 栗本遼太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 岡本一男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 尾藤晴彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shinohara Masahiro 篠原 正浩

SHINOHARA Masahiro 篠原 正浩

Research Projects

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Co-Researchers

RANKL発現を基軸とした不動性骨粗鬆症の発症機序解明Principal Investigator

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骨・骨髄環境の重力制御から迫る進化と宇宙環境への適応Principal Investigator

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力学の理解に基づく代謝異常症及び認知機能障害に対する革新的治療法開発の基盤構築

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身体不活動による骨量低下の分子機序解明と骨量低下抑制法の確立Principal Investigator

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Molecular mechanisms of how mechanical stresses alleviate chronic inflammation of the brain and muscles induced by physical inactivity

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Mechanism for suppression of osteoclastic bone resorption by mechanical stress in bonePrincipal Investigator

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Systems Bone BiologyPrincipal Investigator

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骨代謝を制御する重力シグナルにおけるPI3Kの重要性の解明Principal Investigator

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Molecular Mechanisms of How Mechanical Stress Regulates Inflammation of Locomotive Organs

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宇宙における骨量低下の謎に迫る―破骨細胞分化因子RANKLの発現メカニズムの解明Principal Investigator

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A novel mechanism for osteoblastic bone formation regulated by osteocytesPrincipal Investigator

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Role of osteoclasts in metabolic syndromePrincipal Investigator

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Basic research for the understanding of osteoclast-specific systemsPrincipal Investigator

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Shinohara Masahiro 篠原正浩

SHINOHARA Masahiro 篠原正浩

[Book] 分子リウマチ治療、「次世代の分子ターゲット　Btk」2016