NAKAYAMA Hitoshi 中山仁

Researcher Number	70088863
Other IDs
Affiliation (based on the past Project Information) *help	2008: 熊本大, 教授 2007: Kumamoto University, その他の研究科, 教授 2007: Kumamoto University, 大学院・医学薬学研究部, 教授 2005 – 2006: 熊本大学, 大学院医学薬学研究部, 教授 2002 – 2005: Kumamoto University, Graduate School of Medical and Pharmaceutical Sciences, Professor, 大学院・医学薬学研究部, 教授 … More 2004: Kumamoto University, Professor, 大学院・医学薬学研究部, 教授 1993 – 2002: Kumamoto University Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 1992: 北海道大学, 薬学部, 助手授 1992: 北海道大学, 薬学部, 助教授 1986 – 1992: 北海道大学, 薬学部, 助手 1988: 北海道大学, 薬学部, 助手 1985: 北海道大学, 薬, 助手 Less
Review Section/Research Field	Principal Investigator 医薬分子機能学 / Biological pharmacy / Chemical pharmacy / Drug development chemistry / Biological Sciences / Biological pharmacy Except Principal Investigator Chemical pharmacy / Biological pharmacy / Thoracic surgery / Experimental pathology / Biological pharmacy / Physical pharmacy / Circulatory organs internal medicine
Keywords	Principal Investigator CD36 / 光アフィニティラベル / スカベンジャー受容体 / グリベンクラミド / photoaffinity labeling / 脳虚血 / アルツハイマー病 / マクロファージ / Naチャンネル / ジヒドロピリジン化合物 … More / drug design / new compounds / drug binding site / 精密合成化学 / ドラッグデザイン / 新規化合物 / 薬物結合部位 / 光アフィニティラベリング / Ca拮抗薬 / ミクログリア / 単クローン抗体 / Aβクリアランス / コレステロール代謝 / ACAT / スルホニルウレア / 二次元結晶 / エナンチオマー / L型Caチャンネル / ジヒドロピリジン / 心筋イオンチャンネル / 抗ペプチド抗体 / 部位特異的抗体 / scavenger receptors / MS / ESI-MS / TOF-MS / cholesterol metabolism / macrophage / glibenclamide / 心筋Caチャンネル / synthesic chemistry / calcium antagonist / 抗リガンド抗体 / 心筋L型Caチャンネル / 結合部位の同定 / 神経細胞 / 特異的抗体 / 酸化ストレス / 抗炎症性サイトカイン / サブタイプ / ミクログリアサブタイプ / 肥満 / 脂肪細胞 / クリアランス / 心筋 / スルホニルウレア受容体 / 光学分割 / K^+チャンネル / Na^+チャンネル / Ca^<2+>チャンネル / タンパク質リン酸化 / 光アフィニテイラベル / 制御機構 / 蛋白質リン酸化 / イオンチャネル / Antibodies / Photoaffinity Labeling / Sodium Channel Structure Function / 糖ペプチド / テトロドトキシン / トポロジー / ナトリウムチャンネル / 糖鎖結合部位 / 光親和性標識 / 機能部位 / Naチャンネルの分子構造 / clearance / β-amyloid peptide / Alzheimer's disease / microglia / adipocytes / CD3b / ACAT阻害剤 / β-アミロイドペプチド / ACAT inhibitors / sulfonylurea / ACAT阻害作用 / identifying binding sites / photolabeled peptide fragments / anti-peptide antibodies / 神経特異的ハチ青 / ラベル化ペプチド解析 / TDF-MS / ラベル化ペプチド断片 / atherosclerosis / sulfonylureas / 動脈硬化 / structural biology / Calcium antagonist / 薬理活性 / 構造生物学 / 光アフィニティラベリング / cardiac calsium channel / 精密合成科学 / cardiac calcium channel / ベンゾチアゼピン化合物 / Photoaffinity labeling / Anti-arrhythmic analog / Candidate protein / ATP-sensitive K^+channel / Drug binding sites / Dihydropyridine reagent / Cardiac Ca^<2+>channel / Ca^<2+>放出チャンネル / 蛍光抗体法 / 光アフィニテイラベリング / 抗不整脈薬アナローグ / 候補タンパクの単離 / ATP感受性K^+チャンネル / ジヒドロピリジン型試薬 / 心筋Ca^<2+>チャンネル / 不活性化過程 / Aキナーゼ / サブユニット / カルシウム放出チャネル / 電位依存性チャネル / カルシウムチャネル / 心筋症 / モノクローン抗体 / Caポンプ / Ca放出チャンネル / Caチャンネル / 特発性心筋症 / mono-specific抗体 / 合成ペプチド / アミノ酸配列 / モノクローナル抗体 / ラット脳 / ハイブリッド分子 / 癌 / シグナル伝達 / 分子認識 / 生物・生体工学 / 脳神経疾患 / モルヒネアナローグ / レチノイド化合物 / レチノイド / インターロイキン-4 / 細胞系譜 / 病態モデルマウス / 神経保護作用 / ミクログリアサブタイプ / 糖尿病 / アディポサイトカイン / クリベンクラミド / 開口薬 / K-ATPチャンネル / スルホニルウレア剤 / ホモロジー / K-ATPチャネル / トリチウム標識 / 抗不整脈薬 / イオン透過孔 / ラベル部位 / リン酸化 / IP_3誘発性Ca放出チャンネル / 単クロ-ン抗体 / Ca誘発性Ca放出チャンネル … More Except Principal Investigator 生物発光 / CD36 / ナトリウムチャンネル / エクオリン / DNA / 月夜茸 / Photoaffinity Labeling / Tetrodotoxin / Biospecific Reagents / Sodium channel / 250Kタンパク / 特異的ラベル / 結合実験 / 電気ウナギ / ナトリゥムチャンネル / テトロドトキシン誘導体 / 新しい光反応性基 / 光親和性標識 / テトロドトキシン / 生物特異的試薬 / Adipocytes / Metabolic syndrome / Oxidative stress / 生活習慣病 / アディポカイン / アディポサイトカイン / 脂肪細胞 / メタボリックシンドローム / 酸化ストレス / Heart Failure / Remodeling / Lethal Arrhtymia / Cardiomyopathic hamster / K Channel / Ca Channel / HERG Channel / Arrhythmia / Ion Channel / 圧負荷 / ペースメーカーチャネル / 容積感受性クロールチャネル / 心不全 / 心肥大 / HERG電流密度減少 / チャネル蛋白発現 / 蛋白チロシン燐酸化 / L型Caチャネル / 一過性外向きKチャネル / チャネルリモデリング / チャネル輸送 / Long QT症候群 / KCNQ1 / HERG / 遺伝子異常 / リモデリング / 致死性不整脈 / 心筋症ハムスター / Kチャネル / Caチャネル / HERGチャネル / 不整脈 / イオンチャネル / antagonist / inflammation / transglutaminase / apoptosis / C5a receptor / chemotaxis / leukocyte / ribosomal protein / 光アフィニティ標識 / C5a / 走化性 / 多核球 / 単球 / リセプターアンタゴニスト / C5aリセプター / C5aアナフィラトキシン / 白血球走化因子 / S19リボソーム蛋白 / amino acid residue / topology analysis / drug binding site / flunitrazepam / ketoprofen / photoaffinity labeling / serum albumin / 阻害挙動 / プローブ / フルニトラゼバム / 血清アルブミン / アミノ酸残基 / トポロジー解析 / 薬物結合部位 / フルニトラゼパム / ケトプロフェン / 光アフィニティラベル / 血清アルグミン / Agonist Selectivity / Channel Current / Voltage-sensitive Ion Channel / NMDA Subtype / Glutamate Receptor Ion Channel / Bilayr Lipid Membrane / Ion Channel Protein / Biosensor / バリノマイシン / 電位作動性イオンチャンネル / グルタミン酸受容性イオンチャンネル / アフィニティークロマトグラフィー / クーロメトリー / 電位作動性ナトリウムイオンチャンネル / グルタミン酸作動性イオンチャンネル / 平面脂質二分子膜 / アゴニスト選択性 / チャンネル電流 / 電位作動性ナトリウムチャンネル / NMDAサブタイプ / グルタミン酸受容体イオンチャンネル / 脂質二分子膜 / イオンチャンネル蛋白質 / バイオセンサー / Nicorandil / ATP binding capacity / photoaffinity labeling method / Glibenclamide / Cromakalim / ATP-sensitive K^+ channel protein / K^+チャネル蛋白 / グリベンクロマイド / 単一チャネル電流 / ATP感受性K^+チャネル / ニコランジル / ATP結合能 / 光アフィニティラベル法 / グリベンクラミド / クロマカリム / ATP感受性K^+チャネル蛋白 / スニホニルウレア / GS-Xポンプ / 抗腫瘍性プロスタグランジン / プロスタサイクリン受容体 / APNIC / Ca^<2+> / 光アフィニディラベリング / PKC / Δ^7-PGA_1 / PET / PGI_2 / 15R-TIC / 受容体 / パッチクランプ法 / クロストーク / 細胞内情報伝達機構 / Gタンパク質 / K-チャネル / Ca-チャネル / シナプス前抑制 / 伝達物質放出 / カルシウムチャンネル / DNAの光切断 / 発光蛋白質 / 化学発光 / 興奮性アミノ酸受容体 / 培養細胞 / 電気生理学 / 神経細胞死防御薬 / カルシュウムチャンネル / 光アフィニティラベル用試薬 / 発光カタツムリ / 発光昆虫 / セレンテラジン / イオンチャンネル / ブレオマイシン / レチノクロム / ランプテロフラビン / 合成エクオリンアナログ Less

Development of a novel Alzheimer's disease drug utilizing neuroprotective action of activated microgliaPrincipal Investigator
- Principal Investigator
  
  KAWAHARA Kohichi, 中山仁
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kumamoto University
先端的ファージディスプレイ法を活用した細胞標的キャリアの開発と急性白血病新治療法Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Kumamoto University
ミクログリア亜種が示す異なった神経保護作用:細胞系譜の解析と疾患治療への応用Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
ミクログリア亜種が示す異なった神経保護作用:起源:分子機構解明と疾患治療への応用Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Elucidation of a novel relationship between the oxidative stress-related products and common diseases
- Principal Investigator
  
  KUNIYASU Akihiko
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kumamoto University
Investigation of molecular mechanisms for common diseases caused by aging and oxidative stress and development of drug candidates aiming the molecular targetsPrincipal Investigator
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kumamoto University
従来の概念にはない脂肪細胞の機能解明-スカベンジ機能・貧食能と生体防御-Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Kumamoto University
The molecular mechanisms of remodeling of ion channels leading to arrhtymias in hypertrophy and cardiomyopathy.
- Principal Investigator
  
  KAWANO Seiko, 平岡昌和
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  Tokyo Medical and Dental University
Analysis of CS5 co-receptor molecule that specifically inhibits chemotaxis of polymorphonuclear leukocytes
- Principal Investigator
  
  YAMAMOTO Tetsuro
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Kumamoto University
Development of chemical and rapid identification of the target molecules and ligand binding sites with high resolutionPrincipal Investigator
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University
Development of novel anti-atheroscleroic agentsPrincipal Investigator
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
新たに見い出した抗糖尿病薬結合タンパク質の同定と動脈硬化抑制薬開発の検討Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Kumamoto University
新しいスルホニルウレア結合タンパク質の同定およびK-ATPチャネルとの機能協関Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
標的分子の構造情報に基づく分子設計及び有機合成
- Principal Investigator
  
  鈴木正昭
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Gifu University
Topology Analysis of Drug Binding Sites on Serum Proteins using Photoaffinity Labeling Techniques
- Principal Investigator
  
  OTAGIRI Masaki
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  KUMAMOTO UNIVERSITY
Investigation of Novel Function and Its Relation to Diseases for New Taget Proteins to Which Sulfonylureas BindPrincipal Investigator
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
イオンチャンネル機能を実現する超分子構造の化学的,物理学的解析Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
新トランスポーター・スルホニルウレア受容体とK-ATPチャネルの構造と機能の解析Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
心筋でのスルホニルウレア剤とKチャンネル開口薬受容体分子の相関性の解明Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
Drug binding in cardiac calcium channels : Identification and its application to drug developmentPrincipal Investigator
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
Development of the 4th generation calcium antagonists based on molecular revealing the binding sites in calcium channelsPrincipal Investigator
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
イオンチャンネル機能を実現する超分子構造の化学的、物理学的解析Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
Chemical identification of the binding sites for calcium antagonists in cardiac calcium channels and its application to developing new drugsPrincipal Investigator
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kumamoto University
化学的,物理学的手法によるイオンチャンネル超分子構造の解析Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
励起分子の関与する精密構造認識と機能発現
- Principal Investigator
  
  大橋守
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Electro-Communications
新規に開発した分子ツール群の活用による心筋イオンチャンネル群の分子的解析Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
ラット中枢神経での伝達物質放出抑制に関わる細胞内情報伝達機構のクロストーク
- Principal Investigator
  
  三宅教尚
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
Development of Highly Sensitive Bilayr Lipid Membrane Sensors Based on Membrane Proteins
- Principal Investigator
  
  ODASHIMA Kazunori
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Tokyo
  Hokkaido University
Molecular Anatomy of Cardiac Ion Channels by Developing and Applying New Molecular ToolsPrincipal Investigator
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University
  Hokkaido University
励起分子の関与する精密構造認識と機能発現
- Principal Investigator
  
  大橋守
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Electro-Communications
新規分子ツ-ル群の開発と応用による心筋イオンチャンネル群の分子的解析Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
神経細胞死を防ぐ新しい興奮性アミノ酸受容体阻害剤の開発
- Principal Investigator
  
  吉井清哲
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu Institute of Technology
励起分子の関与する精密構造認識と機能発現
- Principal Investigator
  
  大橋守
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Electro-Communications
心筋イオンチャンネルの動的解析を目的とした親規分子ツ-ル群の開発Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
Development of a ligand for purification of the ATP-sensitive K^+ channe protein
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University, Medical Research Institute
リン酸化部位特異的抗体を用いたイオンチャネル制御機構の解析Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
心筋症成因の分子的操索-心筋カルシウムチャネル群の動的変化と分化の解析Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
リン酸化部位特異的抗体を用いたイオンチャネル制御機構の解析Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
特発性心筋症成因の分子的探索-心筋カルシウムチャンネル群の動的変化と分化の解析-Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
Molecular Investigation on the Sodium Channel -Its Structure on the Lipid Bilayer and the relevance to Functional SitesPrincipal Investigator
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
免疫学的手法によるNaチャンネルの分子およびその機能の解析Principal Investigator
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1985
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Hokkaido University
Chemical Studies on the Sodium Channel by application of Biospecific Reagents
- Principal Investigator
  
  KANAOKA Yuichi
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Hokkaido University

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[Journal Article] Marked induction of inducible nitric oxide synthase and tumor necrosis factor-a in rat CD40+ microglia by comparison to CD40- microglia2009
- Author(s)
  Kawahara, K., Yoshida, A., Koga, K., Yokoo, S., Kuniyasu, A., Gotoh, T., Sawada, M., Nakayama, H.
- Journal Title
  
  J. Neuroimmunol. 208
  
  Pages: 70-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390031
[Journal Article] A synthetic approach to develop peptide inhibitors delective for brain-type sodium channels on the basis of pompilidotoxin structure2009
- Author(s)
  Yokote, S., Setoguchi, R., Shimizu, E., Kawahara, K., Kuniyasu, A., Shirasaki, T., Takahama, K., Konno, K., Kawai, N., Yamaoka, K., Kinoshita, E., Nakayama H.
- Journal Title
  
  Heterocycles 79
  
  Pages: 925-933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390031
[Journal Article] Linkage between Phosphorylation of the Origin Recognition Complex and Its ATP Binding Activity in Saccharomyces cerevisiae2009
- Author(s)
  Makise, M., Takehara, M., Kuniyasu, A., Matsui, N., Nakayama, H., Mizushima, T.
- Journal Title
  
  J. Biol. Chem 284
  
  Pages: 3396-3407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390031
[Journal Article] Constitutive overexpression of P-glycoprotein, rather than breast cancer resistance protein or organic cation transporter 1, contributes to acquisition of imatinib-resistance in K562 cells2008
- Author(s)
  Hirayama, C., Watanabe, H., Nakashima, R., Nanbu, T., Hamada, A., Kuniyasu, A., Nakayama, H., Kawaguchi, T., Saito, H.
- Journal Title
  
  Pharm. Res 25
  
  Pages: 827-835
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390031
[Journal Article] Mutagenicity of 8-nitroguanosine, a product of nitrative nucleoside modification by reactive nitrogen oxides, in mammalian cells2008
- Author(s)
  Kaneko, K., Akuta, T., Sawa, T., Kim, H. W., Fujii, S., Okamoto, T., Nakayama, H., Ohigashi, H., Murakami, A., Akaike, T.
- Journal Title
  
  Cancer Lett 262
  
  Pages: 239-247
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390031
[Journal Article] IL-4-induced selective clearance of oligomeric ・-amyloid peptide_<1-42> by rat type-2 microglia2008
- Author(s)
  Shimizu, E., Kawahara, K., Kajizono, M., Sawada, M., Nakayama, H.
- Journal Title
  
  J. Immunol 181
  
  Pages: 6503-6513
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390031
[Journal Article] Subdomain IIIA of dog albumin contains a binding site similar to site II of human albumin2008
- Author(s)
  Kaneko, K., Fukuda, H., Chuang, V. T., Yamasaki, K., Kawahara, K., Nakayama, H., Suenaga, A., Maruyama, T., Otagiri, M.
- Journal Title
  
  Drug Metab. Dispos 36
  
  Pages: 81-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390031
[Journal Article] Seeking "Etwas Neues"--from bioorganic chemistry to Alzheimer's disease2008
- Author(s)
  Nakayama H.
- Journal Title
  
  Yakugaku Zasshi 128
  
  Pages: 1631-1643
- NAID
  110006991378
- Data Source
  KAKENHI-PROJECT-19390031
[Journal Article] Combinatorial targeting of the macropinocytotic pathway in Leukemia and lymphoma cells2008
- Author(s)
  Nishimura, S., Takahashi, S., Kamikatahira, H., Kuroki, Y., Jaalouk, D. E., O'Brien, S., Koivunen, E., Arap, W., Pasqualini, R., Nakayama, H., Kuniyasu, A.
- Journal Title
  
  J. Biol. Chem 283
  
  Pages: 11752-11762
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390031
[Journal Article] Molecular mechanism of interleukin-4 induced apoptosis of microglia in the presence of LPS2007
- Author(s)
  Shimizu, E., Nakayama, H.et al.
- Journal Title
  
  J. Biochem. (in press)
- Data Source
  KAKENHI-PROJECT-18053019
[Journal Article] Mutagenecity of 8-nitroguanosine in mammalian cells2007
- Author(s)
  Kaneko, K., Nakayama, H.et al.
- Journal Title
  
  Cancer Sci. (in press)
- Data Source
  KAKENHI-PROJECT-18053019
[Journal Article] ナトリウムチャネルの比較生物学2006
- Author(s)
  中山仁
- Journal Title
  
  生体の科学 57
  
  Pages: 470-471
- Data Source
  KAKENHI-PROJECT-18053019
[Journal Article] Glycolaldehyde-modified bovine serum albumin downregulates leptin expression in mouse adipocytes via a CD36-mediated pathway2005
- Author(s)
  Y.Unno, M.Sakai, Y.Sakamoto, A.Kuniyasu, R.Nagai, H.Nakayama, S.Horiuchi
- Journal Title
  
  Ann. N.Y. Acad. Sci. 1043
  
  Pages: 696-701
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590054
[Journal Article] Characterization of benzodiazepine binding site on human al-acid glycoprotein using flunitrazepam as a photolabeling agent2005
- Author(s)
  V.T.Chuang, M.Hijioka, M.Katsuki, K.Nishi, T.Hara, K.I.Kaneko, M.Ueno, A.Kuniyasu, H.Nakayama, M.Otagiri
- Journal Title
  
  Biochim. Biophys. Acta 1725
  
  Pages: 385-393
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590054
[Journal Article] Proteasomal degradation of Kir6.2 channel protein and its inhibition by a Na^+ channel blocker aprindine2005
- Author(s)
  H.Tanaka, J.Miake, T.Notsu, K.Sonyama, N.Sasaki, K.Iitsuka, M.Kato, S.Taniguchi, O.Igawa, A.Yoshida, C.Shigemasa, Y.Hoshikawa, Y.Kurata, A.Kuniyasu, H.Nakayama, N.Inagaki, E.Nanba, G.Shiota, T.Morisaki, H.Ninomiya, M.Kitakaze, I.Hisatome
- Journal Title
  
  Biochem. Biophys. Res. Commun. 331
  
  Pages: 1001-1006
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590054
[Journal Article] Advanced glycation end products-modified proteins and oxidized LDL mediate down-regulation of leptin in mouse adipocytes via CD36.2004
- Author(s)
  Unno Y, Sakai M, Sakamoto Y, Kuniyasu A, Nakayama H, Nagai R, Horiuchi S.
- Journal Title
  
  Biochem Biophys Res Commun. 325(1)
  
  Pages: 151-156
- Data Source
  KAKENHI-PROJECT-16590054
[Journal Article] Advanced glycation end products-modified proteins and oxidized LDL mediate down-regulation of leptin in mouse adipocytes via CD362004
- Author(s)
  Y.Unno, M.Sakai, Y.Salcamoto, A.Kuniyasu, H.Nakayama, R.Nagai, S.Horiuchi
- Journal Title
  
  Biochem. Biophys. Res. Commun. 325
  
  Pages: 151-156
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590054
[Patent] ラットI型ミクログリアを特異的に認識するモノクローナル抗体またはその断片2007
- Inventor(s)
  川原浩一, 中山仁, 倉津純一, 中村英夫, 築城裕正
- Industrial Property Rights Holder
  熊本大学
- Industrial Property Number
  2007-501565
- Filing Date
  2007-07-30
- Data Source
  KAKENHI-PROJECT-19390031
[Patent] ラットI型ミクログリアを特異的に認識するモノクローナル抗体2007
- Inventor(s)
  川原浩一, 中山仁, 倉津純一, 中村英夫, 築城裕正
- Industrial Property Rights Holder
  川原浩一, 中山仁, 倉津純一, 中村英夫, 築城裕正
- Filing Date
  2007-07-30
- Data Source
  KAKENHI-PROJECT-19390031
[Patent] ラットI型ミクログリアを特異的に認識するモノクローナル抗体2007
- Inventor(s)
  川原浩一、中山仁、倉津純一、中村英夫、築城裕正
- Industrial Property Rights Holder
  川原浩一、中山仁、倉津純一、中村英夫、築城裕正
- Filing Date
  2007-07-30
- Data Source
  KAKENHI-PROJECT-18053019
[Patent] ラットI型ミクログリアを特異的に認識するモノクローナル抗体2005
- Inventor(s)
  川原浩一, 中山仁
- Industrial Property Rights Holder
  熊本大学, 川原浩一, 中山仁
- Industrial Property Number
  2005-025153
- Filing Date
  2005-02-01
- Data Source
  KAKENHI-PROJECT-15390029
[Patent] 特許願2005
- Inventor(s)
  川原浩一, 中山仁
- Industrial Property Rights Holder
  熊本大学川原浩一中山仁
- Industrial Property Number
  2005-025153
- Filing Date
  2005-02-01
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390029
[Patent] ラットI型ミクログリアを特異的に認識するモノクローナル抗体2005
- Inventor(s)
  川原浩一, 中山仁
- Industrial Property Rights Holder
  熊本大学, 川原浩一, 中山仁
- Industrial Property Number
  2005-025153
- Filing Date
  2005-02-01
- Data Source
  KAKENHI-PROJECT-16047224
[Presentation] 現代的疾患への分子化学的アプローチ - メタボリック症候群とアルツハイマー病を例に2008
- Author(s)
  中山仁
- Organizer
  第10回日本薬学会創薬ビジョンシンポジウム
- Place of Presentation
  東京
- Year and Date
  2008-12-19
- Data Source
  KAKENHI-PROJECT-19390031
[Presentation] 現代的疾患への分子化学的アプローチ -メタボリツク症候群とアルツハイマー病を例に2008
- Author(s)
  中山仁
- Organizer
  第10回日本薬学会創薬ビジョンシンポジウム
- Place of Presentation
  東京
- Year and Date
  2008-12-19
- Data Source
  KAKENHI-PROJECT-19390031
[Presentation] Aβクリアランス能誘導からみたレチノイドのアルツハイマー病治療への可能性.2007
- Author(s)
  中山仁
- Organizer
  日本レチノイド研究会第18回学術集会
- Place of Presentation
  東京
- Year and Date
  2007-11-24
- Data Source
  KAKENHI-PROJECT-18053019
[Presentation] Aβクリアランス能誘導からみたレチノイドのアルツハイマー病治療への可能性2007
- Author(s)
  中山仁
- Organizer
  日本レチノイド研究会第18回学術集会
- Place of Presentation
  東京
- Year and Date
  2007-11-24
- Data Source
  KAKENHI-PROJECT-19390031
[Presentation] Generation of microglia-specific monoclonal antibody that reveals heterogeneous microglial populations in the developing rat brain.2007
- Author(s)
  中山仁
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19390031
[Presentation] Aβクリアランス能誘導からみたレチノイドのアルツハイマー病治療への可能性.2007
- Author(s)
  中山仁
- Organizer
  日本レチノイド研究会第18回学術集会
- Place of Presentation
  東京
- Year and Date
  2007-11-24
- Data Source
  KAKENHI-PROJECT-19390031
[Presentation] Generation of Microglia-Specific monoclonal antibody that reveals heter ogeneous microglial populations in the developing rat brain2007
- Author(s)
  中山仁
- Organizer
  第80回日本生化学会大会第30回日本分子生物学会年会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19390031
[Presentation] Generation of microglia-specific monoclonal antibody that reveals heterogeneous microglial populations in the developing rat brain.2007
- Author(s)
  中山仁
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-18053019

1. KUNIYASU Akihiko (90241348)

# of Collaborated Projects: 22 results

# of Collaborated Products: 10 results
2. HATANAKA Yasumaru (30111181)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. KAWAHARA Kohichi (10347015)

# of Collaborated Projects: 6 results

# of Collaborated Products: 4 results
4. YOSHII Kiyonori (30125364)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
5. ISHIZUKA Tadao (60176203)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
6. KANAOKA Yuichi (50001029)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
7. HARADA Kumiko (70150547)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
8. NAKAYAMA Morio (60164373)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
9. KAI Hirofumi (30194658)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
10. TANIZAWA Kazutaka (90001049)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
11. 豊島近 (70172210)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
12. 辻フレデリック一朗 (80201755)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
13. HIRAOKA Masayasu (80014281)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
14. KAWANO Seiko (00177718)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
15. 大橋守 (70015535)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
16. 斉藤烈 (20026082)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
17. 磯部稔 (00023466)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
18. MIYAZAKI Akira (70253721)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
19. 藤岡聡之 (20133770)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
20. 沢登徹 (00014217)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
21. 野村憲和 (70180776)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
22. DALY John W.

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
23. NAKAJIMA Makoto (50207792)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. HORIKAWA Saburo (10127136)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. ODASHIMA Kazunori (30152507)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. TOHDA Koji (60212065)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. SUGAWARA Masao (50002176)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. UMEZAWA Yoshio (80011724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. KUNIEDA Takehisa (80012649)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. OTAGIRI Masaki (80120145)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. IMAI Teruko (70176478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. IMAMURA Yorishige (30040314)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. YAMAMOTO Tetsuro (60112405)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. NISHINO Norikazu (40145165)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. SEMBA Umeko (50109691)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. KAWAI Nobufumi (00073065)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. MASUDA Katsuyoshi (30190359)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. HIRANO Yuhi (00181181)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. SATO Eisuke (10001059)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 三宅教尚 (30133771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. 柏柳誠 (20169436)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. 鈴木正昭 (90093046)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. 柴崎正勝 (30112767)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. 赤池孝章 (20231798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. BCHWARTZ Arnold

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
46. NABATA Hiroyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
47. SANNO-HE Kunio

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
48. NISHI Takao

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
49. DALY Johm.W

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
50. GLOSSMANN Ha

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAKAYAMA Hitoshi 中山 仁

Research Projects

Research Products

Co-Researchers

Development of a novel Alzheimer's disease drug utilizing neuroprotective action of activated microgliaPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

先端的ファージディスプレイ法を活用した細胞標的キャリアの開発と急性白血病新治療法Principal Investigator

Principal Investigator

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Research Institution

ミクログリア亜種が示す異なった神経保護作用:細胞系譜の解析と疾患治療への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ミクログリア亜種が示す異なった神経保護作用:起源:分子機構解明と疾患治療への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of a novel relationship between the oxidative stress-related products and common diseases

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Investigation of molecular mechanisms for common diseases caused by aging and oxidative stress and development of drug candidates aiming the molecular targetsPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

従来の概念にはない脂肪細胞の機能解明-スカベンジ機能・貧食能と生体防御-Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

The molecular mechanisms of remodeling of ion channels leading to arrhtymias in hypertrophy and cardiomyopathy.

Principal Investigator

Project Period (FY)

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Research Institution

Analysis of CS5 co-receptor molecule that specifically inhibits chemotaxis of polymorphonuclear leukocytes

Principal Investigator

Project Period (FY)

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Research Institution

Development of chemical and rapid identification of the target molecules and ligand binding sites with high resolutionPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Development of novel anti-atheroscleroic agentsPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

新たに見い出した抗糖尿病薬結合タンパク質の同定と動脈硬化抑制薬開発の検討Principal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

新しいスルホニルウレア結合タンパク質の同定およびK-ATPチャネルとの機能協関Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

NAKAYAMA Hitoshi 中山仁