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Okada Yukinori  岡田 随象

… Alternative Names

OKADA YUKINORI  岡田 随象

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Researcher Number 70727411
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-0311-8472
Affiliation (Current) 2025: 大阪大学, 大学院医学系研究科, 教授
2025: 東京大学, 大学院医学系研究科(医学部), 教授
2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, チームディレクター
Affiliation (based on the past Project Information) *help 2022 – 2025: 東京大学, 大学院医学系研究科(医学部), 教授
2021 – 2024: 大阪大学, 大学院医学系研究科, 教授
2016 – 2022: 大阪大学, 医学系研究科, 教授
2017: 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師
2016: 大阪大学, 医学(系)研究科(研究院), 教授
2015: 東京医科歯科大学, 医歯(薬)学総合研究科, 講師
2015: 東京医科歯科大学, 大学院医歯学総合研究科, テニュアトラック講師
Review Section/Research Field
Principal Investigator
Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Medium-sized Section 62:Applied informatics and related fields / Medium-sized Section 48:Biomedical structure and function and related fields / Complex systems / Collagenous pathology/Allergology / Medical genome science
Except Principal Investigator
Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 56040:Obstetrics and gynecology-related / Basic Section 53030:Respiratory medicine-related / Basic Section 56010:Neurosurgery-related … More / Basic Section 56030:Urology-related / Basic Section 52030:Psychiatry-related / Basic Section 49010:Pathological biochemistry-related / Basic Section 58020:Hygiene and public health-related: including laboratory approach / Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 53050:Dermatology-related / Basic Section 53020:Cardiology-related / Basic Section 59040:Nutrition science and health science-related / Basic Section 56020:Orthopedics-related / Broad Section I / Childhood science (childhood environment science) / Ophthalmology / Complex systems Less
Keywords
Principal Investigator
遺伝統計学 / バイオインフォマティクス / 横断的オミクス解析 / 疾患ゲノム解析 / HLA imputation法 / ゲノム / HLA遺伝子 / ゲノム創薬 / 次世代シークエンス / 免疫アレルギー疾患 … More / シングルセル解析 / オミクス解析 / シングルセルシークエンス / 統合シークエンス解析 / ゲノムデータ / ハプロタイプ / poygenic risk score / 最適化理論 / バイインフォマティクス / eQTL効果 / 細胞組織特異性 / 全ゲノムシークエンス / ゲノム解析 / ビッグデータ解析 / バイオマーカー / マイクロRNA / 機械学習 / ビッグデータ / 自己免疫疾患 / MHC領域 / ドラッグ・リポジショニング … More
Except Principal Investigator
ゲノムワイド関連解析 / HLA / GWAS / SNP / 全ゲノム解析 / De Novo mutation / 遺伝子多型 / がん / 関連遺伝子 / 不育症 / RNAシークエンス / COVID-19 / long read sequencing / RNF213 / もやもや病 / メタボローム解析 / メタゲノム解析 / 腸内細菌 / 前立腺癌 / lifestyle / metagenome analysis / short chain fatty acid / metabolome analysis / life style / microbiome / prostate cancer / 神経免疫 / サイトカイン / 分子間相互作用 / オミクス解析 / オキシトシン / 自閉スペクトラム症 / ロングリード / 脳腫瘍 / 中枢神経系胚細胞腫 / 症例対照研究 / コホート / 媒介分析 / くる病 / 骨疾患 / 代謝性骨疾患 / 骨形成 / 骨芽細胞 / FGF23 / リン代謝 / 骨折 / 遺伝子発現 / 骨系統疾患 / 低リン血症性くる病 / 骨形成不全症 / 骨細胞 / 乾癬 / インスリン受容体 / PI3K/Aktシグナル / メタボリック症候群 / 尋常性乾癬 / リスク予測 / 突然死 / 複雑形質 / 人種特異性 / マルチオミックス解析 / リスク層別化 / ポリジニックリスクスコア / 選択的スプライシング / 人種横断的解析 / ブルガダ症候群 / 労働生産性 / 睡眠障害 / 頭痛 / 健康診断 / レセプター / ctHPVDNA / リキッドバイオプシー / マイクロバイオーム / 前癌病変 / ヒトパピローマウイルス / 中咽頭癌 / 遺伝子多型間相互作用 / Whole genome sequence / TLR3 / IKZF1 / 遺伝子間相互作用 / 感冒薬 / Stevens-Johnson症候群 / 疾患関連遺伝子 / 体軸生脊椎関節炎 / HLA B-27 / ワクチン療法 / HLA B-27 / ワクチン / 強直性脊椎炎 / 療法 / IL-17A / B-27 / 脊椎関節炎 / 運動器学 / 整形外科学 / 統合運動器学 / ヒトゲノム解析 / 運動器恒常性維持 / シングルセル解析 / 骨粗鬆症 / 関節リウマチ / 変形性関節症 / 運動器科学 / 出生コホート / 遺伝子型 / アレルゲン感作 / 全ゲノム関連解析 / アレルギー / 眼生化学・分子生物学 / 遺伝子 / 次世代シークエンサー / 全ゲノムシークエンス解析 / 全ゲノムシークエンス / 発症予測 / variants / 遺伝子解析 / ゲノム科学 / 人工知能 / バイオインフォマティクス / 統計的モデリング / システム生物学 Less
  • Research Projects

    (25 results)
  • Research Products

    (70 results)
  • Co-Researchers

    (107 People)
  •  Trans-Omics Single Cell Projectionによる免疫アレルギー疾患の病態解明Principal Investigator

    • Principal Investigator
      岡田 随象
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
    • Research Institution
      The University of Tokyo
  •  大規模ゲノムワイド媒介分析による新規発がんメカニズム・ハイリスク集団の解明

    • Principal Investigator
      松尾 恵太郎
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 58020:Hygiene and public health-related: including laboratory approach
    • Research Institution
      Aichi Cancer Center Research Institute
  •  Elucidation of genetic factors of moyamoya disease and search for therapeutic targets using long read sequencing

    • Principal Investigator
      宮脇 哲
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      The University of Tokyo
  •  Large-scale cross-ancestry multi-omics study to elucidate the pathogenesis of COVID-19 severity and Long COVID

    • Principal Investigator
      中西 智子
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      The University of Tokyo
  •  ゲノムワイド関連解析による原因不明不育症の病因解明とライフプラン設計への応用

    • Principal Investigator
      矢野 好隆
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Nagoya City University
  •  メタボリック症候群と乾癬発症におけるPI3K/Akt経路の関与の検討

    • Principal Investigator
      中島 喜美子
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53050:Dermatology-related
    • Research Institution
      Kochi University
  •  Elucidation of immune and allergic disease dynamics by integrative sequencing analysisPrincipal Investigator

    • Principal Investigator
      岡田 随象
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
    • Research Institution
      The University of Tokyo
  •  ロングリード技術を用いた統合ゲノム解析による中枢神経系胚細胞腫の病態解明

    • Principal Investigator
      市村 幸一
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 49010:Pathological biochemistry-related
    • Research Institution
      Kyorin University
      Juntendo University
  •  自閉症中核症状の新規治療シーズ創出:RCTベースの多層オミクスと検証的動物実験

    • Principal Investigator
      山末 英典
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52030:Psychiatry-related
    • Research Institution
      Hamamatsu University School of Medicine
  •  Diagnostic strategy for prostate cancer based on multifaceted analyses of genetic background, life style and gut microbiome

    • Principal Investigator
      野々村 祝夫
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Osaka University
  •  健診・ゲノムデータを統合したテーラーメイド型ヘルスプロモーションシステムの開発

    • Principal Investigator
      松本 ルミネ
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      The University of Tokyo
  •  A multi-omics study to elucidate the novel molecular basis of the complex traits and ethnicity in Brugada syndrome

    • Principal Investigator
      Makita Naomasa
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Analysis of dysfunction of osteocytes to reveal the targets of treatment in genetical bone diseases

    • Principal Investigator
      Ozono Keiichi
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Osaka University
  •  Re-annotation of large-scale human genome data by integration of statistical genetics and operations researchPrincipal Investigator

    • Principal Investigator
      Okada Yukinori
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 62:Applied informatics and related fields
    • Research Institution
      Osaka University
  •  Establishment of an integrated locomotive science including dynamics of bone-articular cells and regulation by immune system

    • Principal Investigator
      Tanaka Sakae
    • Project Period (FY)
      2019 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Review Section
      Broad Section I
    • Research Institution
      The University of Tokyo
  •  Elucidation of disease biology and tissue specificity by trans-layer omics analysis and whole-genome sequencingPrincipal Investigator

    • Principal Investigator
      Okada Yukinori
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 48:Biomedical structure and function and related fields
    • Research Institution
      Osaka University
  •  Natural history of HPV-related oropharyngeal cancer

    • Principal Investigator
      INOHARA HIDENORI
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
    • Research Institution
      Osaka University
  •  Development of a therapeutic vaccine targeting IL17A for treatment of spondyloarthritis.

    • Principal Investigator
      Tomita Tetsuya
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      Osaka University
  •  Construction and validation of an algorithm for disease pathogenesis by exhaustive computational analysis

    • Principal Investigator
      Kinoshita Shigeru
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Research on development of a prediction system for the onset of severe ocular surface disease by analysis of gene polymorphism interaction

    • Principal Investigator
      Kinoshita Shigeru
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Ophthalmology
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Elucidation of the Gene and Environment factor for Allergic Diseases using an birth cohort study

    • Principal Investigator
      Emiko Noguchi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Childhood science (childhood environment science)
    • Research Institution
      University of Tsukuba
  •  Development of the novel drug repositioning method based on disease geneticsPrincipal Investigator

    • Principal Investigator
      OKADA YUKINORI
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Medical genome science
    • Research Institution
      Osaka University
      Tokyo Medical and Dental University
  •  Identification of biomarkers of autoimmune diseases using HLA imputationPrincipal Investigator

    • Principal Investigator
      Okada Yukinori
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Collagenous pathology/Allergology
    • Research Institution
      Osaka University
      Tokyo Medical and Dental University
  •  Strategies for research policies in the area

    • Principal Investigator
      MIYANO SATORU
    • Project Period (FY)
      2015 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      The University of Tokyo
  •  Statistical genetics and big data contribute to novel cancer drug discoveryPrincipal Investigator

    • Principal Investigator
      Okada Yukinori
    • Project Period (FY)
      2015 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      Osaka University
      Tokyo Medical and Dental University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

  • [Book] 医学のあゆみ2024

    • Author(s)
      岡田随象、中西智子
    • Total Pages
      5
    • Publisher
      医歯薬出版
    • Data Source
      KAKENHI-PROJECT-23K27608
  • [Book] ゼロから実践する 遺伝統計学セミナー2020

    • Author(s)
      岡田 随象
    • Total Pages
      247
    • Publisher
      羊土社
    • ISBN
      9784758120920
    • Data Source
      KAKENHI-PROJECT-19H01021
  • [Book] ゼロから実践する 遺伝統計学セミナー2020

    • Author(s)
      岡田 随象
    • Total Pages
      247
    • Publisher
      羊土社
    • ISBN
      9784758120920
    • Data Source
      KAKENHI-PLANNED-15H05911
  • [Journal Article] Genetic Risk of Primary Aldosteronism and Its Contribution to Hypertension: A Cross-Ancestry Meta-Analysis of Genome-Wide Association Studies2023

    • Author(s)
      Naito Tatsuhiko、Inoue Kosuke、Sonehara Kyuto、Baba Ryuta、Kodama Takaya、Otagaki Yu、Okada Akira、Itcho Kiyotaka、Kobuke Kazuhiro、Kishimoto Shinji、Yamamoto Kenichi、Morisaki Takayuki、Higashi Yukihito、Hinata Nobuyuki、Arihiro Koji、Hattori Noboru、Okada Yukinori、Oki Kenji、BioBank Japan
    • Journal Title

      Circulation

      Volume: 147 Issue: 14 Pages: 1097-1109

    • DOI

      10.1161/circulationaha.122.062349

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K20929, KAKENHI-PROJECT-22H00476, KAKENHI-PROJECT-21K08557, KAKENHI-PROJECT-23K24329
  • [Journal Article] Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity2023

    • Author(s)
      Japan COVID-19 Task Force
    • Journal Title

      Nature Genetics

      Volume: 55 Issue: 5 Pages: 753-767

    • DOI

      10.1038/s41588-023-01375-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K16624, KAKENHI-PROJECT-23K14451, KAKENHI-PROJECT-22K08283, KAKENHI-PROJECT-23K11300, KAKENHI-PROJECT-21K09068, KAKENHI-PROJECT-22K15493, KAKENHI-PROJECT-22H00476, KAKENHI-PROJECT-23K27671
  • [Journal Article] Multifaceted analysis of cross-tissue transcriptomes reveals phenotype-endotype associations in atopic dermatitis2023

    • Author(s)
      Sekita A, Kawasaki H, Fukushima-Nomura A, Yashiro K, Tanese K, Toshima S, Ashizaki K, Miyai T, Yazaki J Kobayashi A, Namba S, Naito T, Wang Q S., Kawakami E, Seita J, Ohara O, Sakurada K, Okada Y, Amagai M, Koseki H
    • Journal Title

      Nature Communications

      Volume: 14(1) Issue: 1 Pages: 6133-6133

    • DOI

      10.1038/s41467-023-41857-8

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K08420, KAKENHI-PROJECT-22H04994, KAKENHI-PROJECT-22H00476
  • [Journal Article] Extracting immunological and clinical heterogeneity across autoimmune rheumatic diseases by cohort-wide immunophenotyping2023

    • Author(s)
      Tanaka Hiroaki、Okada Yukinori、Nakayamada Shingo、Miyazaki Yusuke、Sonehara Kyuto et al.
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 83 Issue: 2 Pages: 242-252

    • DOI

      10.1136/ard-2023-224537

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K14451, KAKENHI-PROJECT-22H00476, KAKENHI-PROJECT-23K24465
  • [Journal Article] Reconstruction of the personal information from human genome reads in gut metagenome sequencing data2023

    • Author(s)
      Tomofuji Yoshihiko、Sonehara Kyuto et al.
    • Journal Title

      Nature Microbiology

      Volume: 8 Issue: 6 Pages: 1079-1094

    • DOI

      10.1038/s41564-023-01381-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K14451, KAKENHI-PROJECT-22H00476
  • [Journal Article] Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts2023

    • Author(s)
      Wang Y, Namba S, Lopera E, Kerminen S, Tsuo K, Lall K, Kanai M, Zhou W, Wu KH, Fave MJ, Bhatta L, Awadalla P, Brumpton B, Deelen P, Hveem K, Lo FV, Magi R, Murakami Y, ..., Okada Y et al.
    • Journal Title

      Cell Genomics

      Volume: 3 Issue: 1 Pages: 100241-100241

    • DOI

      10.1016/j.xgen.2022.100241

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22H00476, KAKENHI-PROJECT-20H03525
  • [Journal Article] Genome-wide association study identifies risk loci within the major histocompatibility complex region for Hunner-type interstitial cystitis2023

    • Author(s)
      Akiyama Y、Sonehara K、Maeda D、Katoh H、Naito T、Yamamoto K、Morisaki T、Ishikawa S、Ushiku T、Kume H、Homma Y、Okada Y
    • Journal Title

      Cell Reports Medicine

      Volume: 4 Issue: 7 Pages: 101114-101114

    • DOI

      10.1016/j.xcrm.2023.101114

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K16788, KAKENHI-PROJECT-23K14451, KAKENHI-PROJECT-22K07538, KAKENHI-PROJECT-22H00476
  • [Journal Article] Pan-cancer and cross-population genome-wide association studies dissect shared genetic backgrounds underlying carcinogenesis2023

    • Author(s)
      Sato Go、Shirai Yuya、Namba Shinichi、Edahiro Ryuya、Sonehara Kyuto et al.
    • Journal Title

      Nature Communications

      Volume: 14 Issue: 1 Pages: 3671-3671

    • DOI

      10.1038/s41467-023-39136-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K14451, KAKENHI-PROJECT-22K07538, KAKENHI-PROJECT-23K08128, KAKENHI-PROJECT-22H00476
  • [Journal Article] Analysis of gut microbiome, host genetics, and plasma metabolites reveals gut microbiome-host interactions in the Japanese population2023

    • Author(s)
      Tomofuji Yoshihiko、Kishikawa Toshihiro、Sonehara Kyuto et al.
    • Journal Title

      Cell Reports

      Volume: 42 Issue: 11 Pages: 113324-113324

    • DOI

      10.1016/j.celrep.2023.113324

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K14451, KAKENHI-PROJECT-21K08344, KAKENHI-PROJECT-22H00476
  • [Journal Article] An evolving hypothesis in autoimmune disease genetics2022

    • Author(s)
      Okada Yukinori
    • Journal Title

      Nature Reviews Genetics

      Volume: - Issue: 8 Pages: 458-459

    • DOI

      10.1038/s41576-022-00482-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K21834
  • [Journal Article] Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis2022

    • Author(s)
      Ishigaki K, Sakaue S, Terao C, Luo Y, Sonehara KvYamaguchi K, Amariuta T, Too CL, Laufer VA, Scott IC, Viatte S, Takahashi M, Ohmura K, Murasawa A, Hashimoto M, Ito H, ..., Okada Y et al.
    • Journal Title

      Nature Genetics

      Volume: 54 Issue: 11 Pages: 1640-1651

    • DOI

      10.1038/s41588-022-01213-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22H00476, KAKENHI-PROJECT-20H03722, KAKENHI-PROJECT-21K19501, KAKENHI-PROJECT-21K20647, KAKENHI-PROJECT-23K24373, KAKENHI-PROJECT-23K24465, KAKENHI-PROJECT-22H04923
  • [Journal Article] DOCK2 is involved in the host genetics and biology of severe COVID-192022

    • Author(s)
      Namkoong Ho、et al.
    • Journal Title

      Nature

      Volume: 609 Issue: 7928 Pages: 754-760

    • DOI

      10.1038/s41586-022-05163-5

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08606, KAKENHI-PROJECT-22K08283, KAKENHI-PROJECT-18H05282, KAKENHI-PROJECT-22H00476, KAKENHI-PROJECT-20H03684, KAKENHI-PROJECT-19K08650, KAKENHI-PROJECT-20K16453
  • [Journal Article] Decoding the diversity of killer immunoglobulin-like receptors by deep sequencing and a high-resolution imputation method2022

    • Author(s)
      Sakaue S, Hosomichi K, Hirata J, Nakaoka H, Yamazaki K, Yawata M, Yawata N, Naito T, Umeno J, Kawaguchi T, Matsui T, Motoya S, Suzuki Y, Inoko H, Tajima A, Morisaki T, Matsuda K, Kamatani Y, Yamamoto K, Inoue I, Okada Y
    • Journal Title

      Cell Genomics

      Volume: 2 Issue: 3 Pages: 100101-100101

    • DOI

      10.1016/j.xgen.2022.100101

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K21705, KAKENHI-PROJECT-20K21834, KAKENHI-PUBLICLY-21H00342, KAKENHI-PROJECT-19H01021, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-21K09723
  • [Journal Article] The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force2022

    • Author(s)
      Wang Qingbo S.、et al.
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 4830-4830

    • DOI

      10.1038/s41467-022-32276-2

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08606, KAKENHI-PROJECT-22K08283, KAKENHI-PROJECT-18H05282, KAKENHI-PROJECT-22H00476, KAKENHI-PROJECT-20H03684, KAKENHI-PROJECT-19K08650, KAKENHI-PROJECT-20K16453, KAKENHI-PROJECT-20K17460
  • [Journal Article] OMARU: a robust and multifaceted pipeline for metagenome-wide association study2022

    • Author(s)
      Kishikawa Toshihiro、Tomofuji Yoshihiko、Inohara Hidenori、Okada Yukinori
    • Journal Title

      NAR Genomics and Bioinformatics

      Volume: 4 Issue: 1

    • DOI

      10.1093/nargab/lqac019

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H01021
  • [Journal Article] Localization and potential role of prostate microbiota2022

    • Author(s)
      Okada K, Takezawa K, Tsujimura G, Imanaka T, Kuribayashi S, Ueda N, Hatano K, Fukuhara S, Kiuchi H, Fujita K, Motooka D, Nakamura S, Koyama Y, Shimada S, Nonomura N
    • Journal Title

      Front Cell Infect Microbiol.

      Volume: 12 Pages: 1048319-1048319

    • DOI

      10.3389/fcimb.2022.1048319

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K24471
  • [Journal Article] Multi-trait and cross-population genome-wide association studies across autoimmune and allergic diseases identify shared and distinct genetic component2022

    • Author(s)
      Shirai Y, Nakanishi Y, Suzuki A, Konaka H, Nishikawa R, Sonehara K, Namba S, Tanaka H, Masuda T, Yaga M, Satoh S, Izumi M, Mizuno Y, Jo T, Maeda Y, Nii T, Oguro-Igashira E, Morisaki T, Kam, Nakayamada S, Nishigori C, Tanaka Y, Takeda Y, Yamamoto K, Kumanogoh A, Okada Y, The Biobank Japan Project
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 81 Issue: 9 Pages: 1301-1312

    • DOI

      10.1136/annrheumdis-2022-222460

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22H00476, KAKENHI-PROJECT-19K08650
  • [Journal Article] A saturated map of common genetic variants associated with human height2022

    • Author(s)
      Yengo L, Nakatochi M, Yamamoto K, Ichihara S, Yokota M, et al
    • Journal Title

      Nature

      Volume: 610 Issue: 7933 Pages: 704-712

    • DOI

      10.1038/s41586-022-05275-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K10514, KAKENHI-PROJECT-21H04850, KAKENHI-PROJECT-22H00476, KAKENHI-PROJECT-21H03206, KAKENHI-PROJECT-19K19434
  • [Journal Article] A common deletion at BAK1 reduces enhancer activity and confers risk of intracranial germ cell tumors2022

    • Author(s)
      Sonehara K、Kimura Y、Nakano Y、Ozawa T、Takahashi M、Suzuki K、Fujii T、Matsushita Y、Tomiyama A、Kishikawa T、Yamamoto K、Naito T、Suzuki T、Yamaguchi S、Miwa T、Sasaki H、Kitagawa M、Ohe N、Fukai J、Ogiwara H、Kawamura A、Miyawaki S、Matsuda F、Kiyokawa N、Ichimura K、Nishikawa R、Okada Y、Terashima K
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 4478-4478

    • DOI

      10.1038/s41467-022-32005-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K09380, KAKENHI-PROJECT-21K09161, KAKENHI-PROJECT-22H00476
  • [Journal Article] A deep learning method for HLA imputation and trans-ethnic MHC fine-mapping of type 1 diabetes2021

    • Author(s)
      Naito Tatsuhiko、Suzuki Ken、Hirata Jun、Kamatani Yoichiro、Matsuda Koichi、Toda Tatsushi、Okada Yukinori
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 1639-1639

    • DOI

      10.1038/s41467-021-21975-x

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01021, KAKENHI-PROJECT-20J12189, KAKENHI-PROJECT-20K21834, KAKENHI-PROJECT-18H01085
  • [Journal Article] A cross-population atlas of genetic associations for 220 human phenotypes2021

    • Author(s)
      Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, Ishigaki K, Suzuki A, Suzuki K, Obara W, Yamaji K, Takahashi K, Asai S, Takahashi Y, Suzuki T, Shinozaki N, Yamaguchi H, Minami S, Murayama S, Yoshimori K, Nagayama S, Obata D, Higashiyama M, Masumoto A, et al.
    • Journal Title

      Nature Genetics

      Volume: 53 Issue: 10 Pages: 1415-1424

    • DOI

      10.1038/s41588-021-00931-x

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-21H00179, KAKENHI-PROJECT-19H01021, KAKENHI-PROJECT-21K10439
  • [Journal Article] A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response2021

    • Author(s)
      Luo Yang、Kanai Masahiro、...、Okada Yukinori、Han Buhm、McLaren Paul J.、Raychaudhuri Soumya
    • Journal Title

      Nature Genetics

      Volume: 53 Issue: 10 Pages: 1504-1516

    • DOI

      10.1038/s41588-021-00935-7

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K21834
  • [Journal Article] Genetic architecture of microRNA expression and its link to complex diseases in the Japanese population2021

    • Author(s)
      Sonehara Kyuto、Sakaue Saori、Maeda Yuichi、Hirata Jun、Kishikawa Toshihiro、Yamamoto Kenichi、Matsuoka Hidetoshi、Yoshimura Maiko、Nii Takuro、Ohshima Shiro、Kumanogoh Atsushi、Okada Yukinori
    • Journal Title

      Human Molecular Genetics

      Volume: - Issue: 11 Pages: 1806-1820

    • DOI

      10.1093/hmg/ddab361

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01021, KAKENHI-PROJECT-22H00476
  • [Journal Article] Metagenome-wide association study revealed disease-specific landscape of the gut microbiome of systemic lupus erythematosus in Japanese2021

    • Author(s)
      Tomofuji Yoshihiko、Maeda Yuichi、Oguro-Igashira Eri、Kishikawa Toshihiro、Yamamoto Kenichi、Sonehara Kyuto、Motooka Daisuke、Matsumoto Yuki、Matsuoka Hidetoshi、Yoshimura Maiko、Yagita Mayu、Nii Takuro、Ohshima Shiro、Nakamura Shota、Inohara Hidenori、Takeda Kiyoshi、Kumanogoh Atsushi、Okada Yukinori
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 80 Issue: 12 Pages: 1575-1583

    • DOI

      10.1136/annrheumdis-2021-220687

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H05282, KAKENHI-PROJECT-19H01021
  • [Journal Article] Trans‐Ethnic Fine‐Mapping of the Major Histocompatibility Complex Region Linked to Parkinson's Disease2021

    • Author(s)
      Naito Tatsuhiko、Satake Wataru、Ogawa Kotaro、Suzuki Ken、Hirata Jun、Foo Jia Nee、Tan Eng‐King、Toda Tatsushi、Okada Yukinori
    • Journal Title

      Movement Disorders

      Volume: 36 Issue: 8 Pages: 1805-1814

    • DOI

      10.1002/mds.28583

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K21834, KAKENHI-PROJECT-19H01021, KAKENHI-PROJECT-18H01085
  • [Journal Article] Whole gut virome analysis of 476 Japanese revealed a link between phage and autoimmune disease2021

    • Author(s)
      Tomofuji Yoshihiko et al.
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 81 Issue: 2 Pages: 278-288

    • DOI

      10.1136/annrheumdis-2021-221267

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H05282, KAKENHI-PROJECT-19H01021
  • [Journal Article] Population-specific causal disease effect sizes in functionally important regions impacted by selection2021

    • Author(s)
      Shi Huwenbo、Gazal Steven、Kanai Masahiro、Koch Evan M.、Schoech Armin P.、Siewert Katherine M.、Kim Samuel S.、Luo Yang、Amariuta Tiffany、Huang Hailiang、Okada Yukinori、Raychaudhuri Soumya、Sunyaev Shamil R.、Price Alkes L.
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 1098-1098

    • DOI

      10.1038/s41467-021-21286-1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K21834, KAKENHI-PROJECT-19H01021
  • [Journal Article] Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power2021

    • Author(s)
      Atkinson Elizabeth G.、Maihofer Adam X.、Kanai Masahiro、Martin Alicia R.、Karczewski Konrad J.、Santoro Marcos L.、Ulirsch Jacob C.、Kamatani Yoichiro、Okada Yukinori、Finucane Hilary K.、Koenen Karestan C.、Nievergelt Caroline M.、Daly Mark J.、Neale Benjamin M.
    • Journal Title

      Nature Genetics

      Volume: 53 Issue: 2 Pages: 195-204

    • DOI

      10.1038/s41588-020-00766-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K21834, KAKENHI-PROJECT-19H01021
  • [Journal Article] Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps2021

    • Author(s)
      Polygenic Risk Score Task Force of the International Common Disease Alliance
    • Journal Title

      Nature Medicine

      Volume: 27 Issue: 11 Pages: 1876-1884

    • DOI

      10.1038/s41591-021-01549-6

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K21834, KAKENHI-PROJECT-19H01021
  • [Journal Article] GWAS of 165,084 Japanese individuals identified nine loci associated with dietary habits.2020

    • Author(s)
      Matoba N, Akiyama M, Ishigaki K, Kanai M, Takahashi A, Momozawa Y, Ikegawa S, Ikeda M, Iwata N, Hirata M, Matsuda K, Murakami Y, Kubo M, Kamatani Y, Okada Y
    • Journal Title

      Nat Hum Behav

      Volume: 4 Issue: 3 Pages: 308-346

    • DOI

      10.1038/s41562-019-0805-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-15H05911, KAKENHI-PROJECT-19H01021, KAKENHI-PROJECT-17H03596
  • [Journal Article] Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan2020

    • Author(s)
      Sakaue S, Kanai M, Karjalainen J, Akiyama M, Kurki M, Matoba N, Takahashi A, Hirata M, Kubo M, Matsuda K, Murakami Y; FinnGen, Daly MJ, Kamatani Y, Okada Y
    • Journal Title

      Nat Med

      Volume: 26 Issue: 4 Pages: 542-548

    • DOI

      10.1038/s41591-020-0785-8

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-15H05911, KAKENHI-PROJECT-19H01021, KAKENHI-PROJECT-17H03596, KAKENHI-PROJECT-16H02676
  • [Journal Article] Dimensionality reduction reveals fine-scale structure in the Japanese population with consequences for polygenic risk prediction2020

    • Author(s)
      Sakaue S, Hirata J, Kanai M, Suzuki K, Akiyama M, Lai Too C, Arayssi T, Hammoudeh M, Al Emadi S, Masri BK, Halabi H, Badsha H, Uthman IW, Saxena R, Padyukov L, Hirata M, Matsuda K, Murakami Y, Kamatani Y, Okada Y
    • Journal Title

      Nat Commun

      Volume: 11 Issue: 1 Pages: 1569-1569

    • DOI

      10.1038/s41467-020-15194-z

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-15H05911, KAKENHI-PROJECT-19H01021, KAKENHI-PROJECT-17H03596, KAKENHI-PROJECT-19K17962
  • [Journal Article] Fine Mapping of the Major Histocompatibility Complex Region and Association of the HLA-B*52:01 Allele With Cervical Cancer in Japanese Women2020

    • Author(s)
      Masuda Tatsuo、Ito Hidemi、Hirata Jun、Sakaue Saori、Ueda Yutaka、Kimura Tadashi、Takeuchi Fumihiko、Murakami Yoshinori、Matsuda Koichi、Matsuo Keitaro、Okada Yukinori
    • Journal Title

      JAMA Network Open

      Volume: 3 Issue: 10 Pages: e2023248-e2023248

    • DOI

      10.1001/jamanetworkopen.2020.23248

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-19H01021
  • [Journal Article] Obelisc: an identical-by-descent mapping tool based on SNP streak2020

    • Author(s)
      Sonehara Kyuto、Okada Yukinori
    • Journal Title

      Bioinformatics

      Volume: 36 Issue: 24 Pages: 5567-5570

    • DOI

      10.1093/bioinformatics/btaa940

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H01021
  • [Journal Article] Metagenome-wide association study of gut microbiome revealed novel aetiology of rheumatoid arthritis in the Japanese population2020

    • Author(s)
      Kishikawa T, Maeda Y, Nii T, Motooka D, Matsumoto Y, Matsushita M, Matsuoka H, Yoshimura M, Kawada S, Teshigawara S, Oguro E, Okita Y, Kawamoto K, Higa S, Hirano T, Narazaki M, Ogata A, Saeki Y, Nakamura S, Inohara H, Kumanogoh A, Takeda K, Okada Y.
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 79(1) Issue: 1 Pages: 103-111

    • DOI

      10.1136/annrheumdis-2019-215743

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10002, KAKENHI-PROJECT-19K16643, KAKENHI-PLANNED-15H05911, KAKENHI-PROJECT-19H01021
  • [Journal Article] A Mendelian randomization study identified obesity as a causal risk factor of uterine endometrial cancer in Japanese2020

    • Author(s)
      Masuda Tatsuo、Ogawa Kotaro、Kamatani Yoichiro、Murakami Yoshinori、Kimura Tadashi、Okada Yukinori
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 12 Pages: 4646-4651

    • DOI

      10.1111/cas.14667

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H01021
  • [Journal Article] A Transethnic Mendelian Randomization Study Identifies Causality of Obesity on Risk of Psoriasis.2019

    • Author(s)
      Ogawa K, Stuart PE, Tsoi LC, Suzuki K, Nair RP, Mochizuki H, Elder JT, Okada Y.
    • Journal Title

      J Invest Dermatol

      Volume: 115 Issue: 6 Pages: 1397-1400

    • DOI

      10.1016/j.jid.2018.11.023

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-15H05911, KAKENHI-PROJECT-19K17962
  • [Journal Article] Genetic and phenotypic landscape of the major histocompatibilty complex region in the Japanese population.2019

    • Author(s)
      Hirata J, Hosomichi K, Sakaue S, Kanai M, Nakaoka H, Ishigaki K, Suzuki K, Akiyama M, Kishikawa T, Ogawa K, Masuda T, Yamamoto K, Hirata M, Matsuda K, Momozawa Y, Inoue I, Kubo M, Kamatani Y, Okada Y.
    • Journal Title

      Nat Genet

      Volume: 51 Issue: 3 Pages: 470-480

    • DOI

      10.1038/s41588-018-0336-0

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-15H05911, KAKENHI-PLANNED-16H06502, KAKENHI-PLANNED-18H05506, KAKENHI-PROJECT-17K19804, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-17H03596
  • [Journal Article] Clinical Characteristics of Patients with Spondyloarthritis in Japan in Comparison with Other Regions of the World.2019

    • Author(s)
      Kishimoto M, Yoshida K, Ichikawa N, Inoue H, Kaneko Y, Kawasaki T, Matsui K, Morita M, Suda M, Tada K, Takizawa N, Tamura N, Taniguchi A, Taniguchi Y, Tsuji S, Haji Y, Rokutanda R, Yanaoka H, Cheung PP, Gu J, Kim TH, Luo SF, Okada M, López Medina C, Molto A, Dougados M, Kobayashi S, van der Heijde D, Tomita T.
    • Journal Title

      J Rheumatol.

      Volume: 46 Issue: 8 Pages: 896-903

    • DOI

      10.3899/jrheum.180412

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K09103
  • [Journal Article] Biological characterization of expression quantitative trait loci (eQTLs) showing tissue-specific opposite directional effects.2019

    • Author(s)
      Mizuno A, Okada Y
    • Journal Title

      Eur J Hum Genet

      Volume: 27 Issue: 11 Pages: 1745-1756

    • DOI

      10.1038/s41431-019-0468-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H01021
  • [Journal Article] Next-generation sequencing identifies contribution of both class I and II HLA genes on susceptibility of multiple sclerosis in Japanese2019

    • Author(s)
      Ogawa, Kotaro; Okuno, Tatsusada; Hosomichi, Kazuyoshi; Hosokawa, Akiko; Hirata, Jun; Suzuki, Ken; Sakaue, Saori; Kinoshita, Makoto; Asano, Yoshihiro; Miyamoto, Katsuichi
    • Journal Title

      Journal of neuroinflammation

      Volume: 16 Issue: 1 Pages: 162-162

    • DOI

      10.1186/s12974-019-1551-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K17962, KAKENHI-PLANNED-15H05911, KAKENHI-PLANNED-16H06502, KAKENHI-PUBLICLY-19H05344, KAKENHI-PROJECT-17K09779, KAKENHI-PROJECT-19H03652, KAKENHI-PROJECT-18K19547
  • [Journal Article] Empirical evaluation of variant calling accuracy using ultra-deep whole-genome sequencing data.2019

    • Author(s)
      Kishikawa T, Momozawa Y, Ozeki T, Mushiroda T, Inohara H, Kamatani Y, Kubo M, Okada Y.
    • Journal Title

      Sci Rep

      Volume: 9 Issue: 1 Pages: 1784-1784

    • DOI

      10.1038/s41598-018-38346-0

    • NAID

      120006818699

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-15H05911
  • [Journal Article] Variants at HLA-A, HLA-C, and HLA-DQB1 confer risk of psoriasis vulgaris in Japanese.2018

    • Author(s)
      Hirata J, --- Saeki H, et al
    • Journal Title

      J Invest Dermatol

      Volume: 138 Issue: 3 Pages: 542-548

    • DOI

      10.1016/j.jid.2017.10.001

    • NAID

      120007134453

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09793, KAKENHI-PLANNED-15H05911, KAKENHI-PROJECT-15H04827, KAKENHI-PROJECT-15H05670
  • [Journal Article] Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases2018

    • Author(s)
      Kanai M, Akiyama M, Takahashi A, Matoba N, Momozawa Y, Ikeda M, Iwata N, Ikegawa S, Hirata M, Matsuda K, Kubo M, Okada Y, Kamatani Y
    • Journal Title

      Nat Genet

      Volume: 50 Issue: 3 Pages: 390-400

    • DOI

      10.1038/s41588-018-0047-6

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-15H05911, KAKENHI-PUBLICLY-16H01566, KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-17H03596, KAKENHI-PROJECT-15H05670, KAKENHI-PROJECT-16H05378, KAKENHI-PROJECT-17H04251
  • [Journal Article] eLD: entropy-based linkage disequilibrium index between multiallelic sites.2018

    • Author(s)
      Okada Y
    • Journal Title

      Hum Genome Var.

      Volume: 5 Issue: 1 Pages: 29-29

    • DOI

      10.1038/s41439-018-0030-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-15H05911
  • [Journal Article] Statist ical genetics and its application to neuroimmunology2018

    • Author(s)
      Ogawa K, Okada Y
    • Journal Title

      Clin Exp Neurol

      Volume: 9 Issue: 1 Pages: 7-12

    • DOI

      10.1111/cen3.12445

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-15H05911, KAKENHI-PROJECT-15H05670
  • [Journal Article] Polygenic burdens on cell-specific pathways underlie the risk of rheumatoid arthritis2017

    • Author(s)
      Ishigaki Kazuyoshi、Kochi Yuta、Suzuki Akari、Tsuchida Yumi、Tsuchiya Haruka、Sumitomo Shuji、Yamaguchi Kensuke、Nagafuchi Yasuo、Nakachi Shinichiro、Kato Rika、Sakurai Keiichi、Shoda Hirofumi、Ikari Katsunori、Taniguchi Atsuo、Yamanaka Hisashi、Miya Fuyuki、Tsunoda Tatsuhiko、et al.、Yamamoto Kazuhiko
    • Journal Title

      Nature Genetics

      Volume: 49 Issue: 7 Pages: 1120-1125

    • DOI

      10.1038/ng.3885

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07211, KAKENHI-PROJECT-17K09972, KAKENHI-PLANNED-15H05911, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-15H04965, KAKENHI-PROJECT-15H05670
  • [Journal Article] Genome-wide association study identifies 112 new loci for body mass index in the Japanese population2017

    • Author(s)
      Akiyama M, Okada Y, Kanai M, Takahashi A, Momozawa Y, Ikeda M, Iwata N, Ikegawa S, Hirata M, Matsuda K, Iwasaki M, Yamaji T, Sawada N, Hachiya T, Tanno K, Shimizu A, Hozawa A, Minegishi N, Tsugane S, Yamamoto M, Kubo M and Kamatani Y
    • Journal Title

      Nat Genet

      Volume: 49 Issue: 10 Pages: 1458-1462

    • DOI

      10.1038/ng.3951

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09464, KAKENHI-PLANNED-15H05911, KAKENHI-PUBLICLY-16H01566, KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-17H01557, KAKENHI-PROJECT-17H03596, KAKENHI-PROJECT-15H05670
  • [Journal Article] Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.2016

    • Author(s)
      Imamura M, ・・Yamauchi T,・・ Shojima N, ・・Kadowaki T
    • Journal Title

      Nat Commun.

      Volume: 7 Issue: 1 Pages: 10531-10531

    • DOI

      10.1038/ncomms10531

    • NAID

      120006889946

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09409, KAKENHI-PUBLICLY-15H01507, KAKENHI-PLANNED-15H05911, KAKENHI-PROJECT-26253058, KAKENHI-PROJECT-15H05670, KAKENHI-PROJECT-26461327, KAKENHI-PROJECT-26000012
  • [Journal Article] Ethnically shared and heterogeneous impacts of molecular pathways suggested by the genome-wide meta-analysis of rheumatoid arthritis.2016

    • Author(s)
      Okada Y, Raj T, Yamamoto K.
    • Journal Title

      Rheumatology

      Volume: 22 Issue: 1 Pages: 186-189

    • DOI

      10.1093/rheumatology/kev314

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K14429, KAKENHI-PLANNED-15H05911, KAKENHI-PROJECT-15H05670
  • [Journal Article] Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity.2016

    • Author(s)
      Mahajan A, Rodan AR, Le TH, Gaulton KJ, Haessler J, ..., Okada Y, Laurie CC, Morris AP, Franceschini N
    • Journal Title

      Am J Hum Gen

      Volume: 99 Issue: 3 Pages: 636-646

    • DOI

      10.1016/j.ajhg.2016.07.012

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-15H05911, KAKENHI-PROJECT-15H05670, KAKENHI-PROJECT-15K14429
  • [Journal Article] Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study.2016

    • Author(s)
      Li Z, Xia Y, Feng LN, Chen JR, Li HM, Cui J, Cai QQ, Sim KS, ..., Okada Y, Raychaudhuri S, Lim ST, Tan W, Peng RJ, Khor CC, Bei JX
    • Journal Title

      Lancet Oncol

      Volume: 17 Issue: 9 Pages: 1240-1247

    • DOI

      10.1016/s1470-2045(16)30148-6

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-15H05911, KAKENHI-PROJECT-15H05670, KAKENHI-PROJECT-15K14429
  • [Journal Article] Significant impact of miRNA-target gene networks on genetics of human complex traits.2016

    • Author(s)
      Okada Y, Muramatsu T, Suita N, Kanai M, Kawakami E et al.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 22223-22223

    • DOI

      10.1038/srep22223

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K14429, KAKENHI-PROJECT-15K21631, KAKENHI-PLANNED-15H05908, KAKENHI-PLANNED-15H05911, KAKENHI-PROJECT-25250019, KAKENHI-PROJECT-15H05670
  • [Journal Article] High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry2016

    • Author(s)
      76.Imamura M, Takahashi A, Yamauchi T, Hara K, Yasuda K, ... Okada Y et al.
    • Journal Title

      Nat Genet

      Volume: 48 Issue: 3 Pages: 323-330

    • DOI

      10.1038/ng.3496

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K14429, KAKENHI-PLANNED-15H05911, KAKENHI-PROJECT-15H05670, KAKENHI-PROJECT-25293225
  • [Journal Article] Systematic analysis of mutation distribution in three dimensional protein structures identifies cancer driver genes2016

    • Author(s)
      Fujimoto A, Okada Y, Boroevich KA, Tsunoda T, Taniguchi H, Nakagawa H
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 26483-26483

    • DOI

      10.1038/srep26483

    • NAID

      120005774574

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-15H05911, KAKENHI-PROJECT-15H05670, KAKENHI-PROJECT-15K14429, KAKENHI-PROJECT-26430196
  • [Journal Article] Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma.2016

    • Author(s)
      Shiraishi K, Okada Y 他44名 Inazawa J 38番目
    • Journal Title

      Nat Commun.

      Volume: 7 Issue: 1 Pages: 12451-12451

    • DOI

      10.1038/ncomms12451

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-15H05908, KAKENHI-PLANNED-15H05911, KAKENHI-PUBLICLY-16H01583, KAKENHI-PROJECT-15H05670, KAKENHI-PROJECT-15K14429, KAKENHI-PROJECT-15K10275, KAKENHI-PROJECT-16K08928, KAKENHI-PROJECT-15K14406, KAKENHI-PROJECT-16H06277
  • [Journal Article] Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis2016

    • Author(s)
      Okada Y, Suzuki A, Ikari K, Terao C, Kochi Y, Ohmura K, Higasa K, Akiyama M, Ashikawa K, Kanai M, Hirata J, Suita N, Teo YY, Xu H, Bae SC, Takahashi A, Momozawa Y, Matsuda K, Momohara S, Taniguchi A, Yamada R, Mimori T, Kubo M, Brown MA, Raychaudhuri S, Matsuda F, Yamanaka H, Kamatani Y, Yamamoto K
    • Journal Title

      Am J Hum Genet

      Volume: 99 Issue: 2 Pages: 366-374

    • DOI

      10.1016/j.ajhg.2016.06.019

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-15H05911, KAKENHI-PROJECT-15H04965, KAKENHI-PROJECT-15H05670, KAKENHI-PROJECT-15K10496, KAKENHI-PROJECT-15K14429
  • [Journal Article] Empirical estimation of genome-wide significance thresholds based on the 1000 Genomes Project data set2016

    • Author(s)
      Kanai M, Tanaka T, Okada Y
    • Journal Title

      J Hum Genet

      Volume: 61 Issue: 10 Pages: 861-866

    • DOI

      10.1038/jhg.2016.72

    • NAID

      40020966136

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-15H05911, KAKENHI-PROJECT-15H05670, KAKENHI-PROJECT-15K14429
  • [Journal Article] The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1.2016

    • Author(s)
      Li G, Cunin P, Wu D, Diogo D, Yang Y, Okada Y, Plenge RM, Nigrovic PA
    • Journal Title

      PLoS Genet

      Volume: 12 Issue: 9 Pages: e1006292-e1006292

    • DOI

      10.1371/journal.pgen.1006292

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-15H05911, KAKENHI-PROJECT-15H05670, KAKENHI-PROJECT-15K14429
  • [Journal Article] Partitioning heritability by functional annotation using genome-wide association summary statistics2015

    • Author(s)
      Finucane HK, Bulik-Sullivan B, Gusev A, Trynka G, Reshef Y, ... Okada Y et al.
    • Journal Title

      Nat Genet

      Volume: 47 Issue: 11 Pages: 1228-1235

    • DOI

      10.1038/ng.3404

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-15H05911, KAKENHI-PROJECT-15H05670
  • [Journal Article] Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases.2015

    • Author(s)
      Lenz TL, Deutsch AJ, Han B, Hu X, Okada Y et al.
    • Journal Title

      Nat Genet

      Volume: 47 Issue: 9 Pages: 1085-1090

    • DOI

      10.1038/ng.3379

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-15H05911, KAKENHI-PROJECT-15H05670
  • [Journal Article] Directional dominance on stature and cognition in diverse human populations2015

    • Author(s)
      Joshi PK, Esko T, Mattsson H, Eklund N, Gandin I, ... Okada Y et al.
    • Journal Title

      Nature

      Volume: 523 Issue: 7561 Pages: 459-462

    • DOI

      10.1038/nature14618

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-15H05911, KAKENHI-PROJECT-15H05670, KAKENHI-PROJECT-25293168
  • [Journal Article] Anti-citrullinated peptide/protein antibody (ACPA)-negative RA shares a large proportion of susceptibility loci with ACPA-positive RA: a meta-analysis of genome-wide association study in a Japanese population.2015

    • Author(s)
      Terao C, Ohmura K, Kochi Y, Ikari K, Okada Y, Shimizu M, , Kubo M, Yamada R, Taniguchi A, Yamanaka H, Momohara S, Yamamoto K, Mimori T, Matsuda F.
    • Journal Title

      Arthritis Res Ther

      Volume: 17 Issue: 1 Pages: 104-104

    • DOI

      10.1186/s13075-015-0623-4

    • NAID

      120005749954

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460649, KAKENHI-PLANNED-15H05911, KAKENHI-PROJECT-15H05670
  • [Journal Article] Construction of a population-specific HLA imputation reference panel and its application to Graves’ disease risk in Japanese.2015

    • Author(s)
      Okada Y, Momozawa Y, Ashikawa K, Kanai M, Matsuda K et al.
    • Journal Title

      Nat Genet

      Volume: 42 Issue: 7 Pages: 798-802

    • DOI

      10.1038/ng.3310

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K14429, KAKENHI-PROJECT-25293168
  • [Presentation] Statistical genetics, disease biology, and drug discovery2020

    • Author(s)
      Yukinori Okada
    • Organizer
      International Conference on Cancer Systems Biology Beyond
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-15H05907
  • [Presentation] Identification of the risk HLA variants of Graves' disease by applying the HLA imputation method to large scale Japanese genome-wide association study data2015

    • Author(s)
      Okada Y, Momozawa Y, Ashikawa K, Kanai M, Matsuda K et al.
    • Organizer
      17th Asia Pacific League of Associations for Rheumatology Congress
    • Place of Presentation
      Chennai, India
    • Year and Date
      2015-09-05
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-15H05911
  • [Presentation] Identification of the risk HLA variants of Graves' disease by applying the HLA imputation method to large scale Japanese genome-wide association study data2015

    • Author(s)
      Okada Y, Momozawa Y, Ashikawa K, Kanai M, Matsuda K et al.
    • Organizer
      17th Asia Pacific League of Associations for Rheumatology Congress
    • Place of Presentation
      Chennai, India
    • Year and Date
      2015-09-05
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05670
  • 1.  Kinoshita Shigeru (30116024)
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    # of Collaborated Products: 0 results
  • 86.  Ohya Yukihiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 87.  Morii Wataru
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 88.  Koseki Ryota
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 89.  SHOJIMA Nobuhiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 90.  KAWASAKI Hiroshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 91.  OHMURA Koichiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 92.  MATSUDA Koichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 93.  UEDA Koji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 94.  NARAZAKI Masashi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 95.  TOMIYAMA Arata
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 96.  馬場 隆太
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 97.  宮 冬樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 98.  佐伯 秀久
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 99.  峯岸 直子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 100.  宮井 智浩
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 101.  曽根原 究人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 102.  熊郷 淳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 103.  富田 哲也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 104.  平田 真
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 105.  秋山 佳之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 106.  山本 健
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 107.  中杤 昌弘
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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