YOSHIOKA KOTARO 吉岡耕太郎

Researcher Number	70780641
Other IDs
Affiliation (Current)	2026: 東京科学大学, 総合研究院, 特任講師
Affiliation (based on the past Project Information) *help	2022 – 2024: 東京医科歯科大学, 大学院医歯学総合研究科, 特任助教 2020 – 2022: 東京医科歯科大学, 大学院医歯学総合研究科, プロジェクト助教
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Medium-sized Section 90:Biomedical engineering and related fields / Medium-sized Section 52:General internal medicine and related fields Except Principal Investigator Basic Section 90120:Biomaterials-related / Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 54010:Hematology and medical oncology-related / Medium-sized Section 51:Brain sciences and related fields
Keywords	Principal Investigator アンチセンス核酸 / 核酸医薬 / グリオーシス / 脳血流関門 / 脳血液関門 / DDS / Glymphatic system Except Principal Investigator 核酸医薬 / トランスクリプトーム解析 / RFX遺伝子 … More / RFX / 自閉症スペクトラム障害 / マイクロRNA / アンチセンス核酸 / EBウイルス / glymphatic system / ペプチド / 脳腫瘍 / X線治療 / DDS / 神経変性疾患 / 歯状核赤核淡蒼球ルイ体萎縮症 / 脊髄小脳変性症 Less

Size-tunable drug delivery systems for their application to X-ray therapy for brain tumors
- Principal Investigator
  
  内藤瑞
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  The University of Tokyo
脳移行促進能と核酸結合能を併せ持つ分子を用いた核酸医薬の脳内デリバリー法の開発
- Principal Investigator
  
  原倫太朗
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Tokyo Medical and Dental University
Development of a treatment for chronic active EB virus infection targeting virus-derived microRNAs
- Principal Investigator
  
  新井文子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  St. Marianna University School of Medicine
アンチセンス核酸医薬の挑戦的脳デリバリー技術の創生Principal Investigator
- Principal Investigator
  
  吉岡耕太郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Tokyo Medical and Dental University
Elucidation of novel pathogenic pathways through comprehensive identification of regulatory genes for the autism transcription factor RFX
- Principal Investigator
  
  中山東城
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tokyo Medical and Dental University
Joint international project to establish antisense oligonucleotide therapy for treating Dentatorubral-Pallidoluysian Atrophy (DRPLA)
- Principal Investigator
  
  中山東城
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 51:Brain sciences and related fields
- Research Institution
  Tokyo Medical and Dental University
グリオーシス回避を可能とする2本鎖核酸医薬の開発Principal Investigator
- Principal Investigator
  
  吉岡耕太郎
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Tokyo Medical and Dental University
Overhanging duplex oligonucleotide penetrating BBBPrincipal Investigator
- Principal Investigator
  
  YOSHIOKA KOTARO
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Tokyo Medical and Dental University

All 2023 2022 2021 2020

All Journal Article Presentation Patent

[Journal Article] Change of intracellular calcium level causes acute neurotoxicity by antisense oligonucleotides via CSF route2023
- Author(s)
  Jia Chunyan、Lei Mon Su Su、Yang Ying、Katsuyama Maho、Yoshida-Tanaka Kie、Nagata Tetsuya、Yoshioka Kotaro、Yokota Takanori
- Journal Title
  
  Molecular Therapy - Nucleic Acids
  
  Volume: 31 Pages: 182-196
- DOI
  10.1016/j.omtn.2022.12.010
- Data Source
  KAKENHI-PROJECT-20K21882
[Journal Article] Preferential delivery of lipid-ligand conjugated DNA/RNA heteroduplex oligonucleotide to ischemic brain in hyperacute stage2023
- Author(s)
  Fuying Li , Keiko Ichinose, Satoru Ishibashi, Syunsuke Yamamoto, Eri Iwasawa , Motohiro Suzuki, Kie Yoshida-Tanaka , Kotaro Yoshioka , Tetsuya Nagata , Hideki Hirabayashi, Kaoru Mogushi, Takanori Yokota
- Journal Title
  
  Molecular therapy
  
  Volume: 31 Issue: 4 Pages: 1106-1122
- DOI
  10.1016/j.ymthe.2023.01.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07733, KAKENHI-PROJECT-20K21882
[Journal Article] 神経難病に対する核酸医薬品の開発2021
- Author(s)
  吉岡耕太郎
- Journal Title
  
  実験医学
  
  Volume: 39 Pages: 2834-2840
- Data Source
  KAKENHI-PROJECT-20K21882
[Patent] ２’－修飾ヌクレオシドを含むヘテロ核酸2022
- Inventor(s)
  横田隆徳、吉岡耕太郎
- Industrial Property Rights Holder
  横田隆徳、吉岡耕太郎
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-20K21882
[Patent] ５’－シクロプロピレン修飾を含む核酸分子2022
- Inventor(s)
  横田隆徳、吉岡耕太郎、黒田隆之、小比賀聡、山口卓男
- Industrial Property Rights Holder
  横田隆徳、吉岡耕太郎、黒田隆之、小比賀聡、山口卓男
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-155777
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-20K21882
[Patent] ｓｃｐＢＮＡ又はＡｍＮＡを含むヘテロ核酸2022
- Inventor(s)
  横田隆徳、永田哲也、吉岡耕太郎、小比賀聡、山口卓男
- Industrial Property Rights Holder
  横田隆徳、永田哲也、吉岡耕太郎、小比賀聡、山口卓男
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-20K21882
[Patent] 核酸医薬の毒性軽減剤2022
- Inventor(s)
  横田隆徳、吉岡耕太郎、松林泰毅、小比賀聡、中川治
- Industrial Property Rights Holder
  横田隆徳、吉岡耕太郎、松林泰毅、小比賀聡、中川治
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-104782
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-20K21882
[Patent] ２’－修飾ヌクレオシドを含むヘテロ核酸2021
- Inventor(s)
  横田　隆徳、吉岡　耕太郎
- Industrial Property Rights Holder
  横田　隆徳、吉岡　耕太郎
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-150310
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-20K21882
[Presentation] アンチセンス核酸による急性中枢神経毒性の克服に向けて.2022
- Author(s)
  吉岡耕太郎
- Organizer
  日本核酸医薬学会第7回年会シンポジウム「毒性メカニズムと回避」
- Invited
- Data Source
  KAKENHI-PROJECT-20K21882
[Presentation] A novel structure of oligonucleotides improves ASO-efficacy and alleviates acute toxicity in CNS via intracerebroventricular route.2022
- Author(s)
  Su Su Lei Mon, Kotaro Yoshioka, Jia Chunyan, Taiki Kunieda, Yutaro Asami, Piao Wenying, Kie Tanaka, Kazutaka Nishina, Tetsuya Nagata, Takanori Yokota
- Organizer
  Neuro2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21882
[Presentation] Structure- “neurotoxicity” correlation in antisense oligonucleotides targeting central nervous system.2022
- Author(s)
  Maho Katsuyama, Kotaro Yoshioka, Chunyan Jia, Su Su Lei Mon, Ying Yang, Kie Tanaka, Tetsuya Nagata, Takanori Yokota.
- Organizer
  18th Annual Meeting of the Oligonucleotide Therapeutics Society.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21882
[Presentation] Chemical modifications in gap mitigate late-onset neurotoxicity of gapmer antisense oligonucleotide.2022
- Author(s)
  Takayuki Kuroda, Kotaro Yoshioka, Su Su Lei Mon, Toshihiro Sakamoto, Maho Katsuyama, Kie Yoshida-Tanaka, Rintaro Iwata-Hara, Takao Yamaguchi, Tetsuya Nagata, Satoshi Obika, Takanori Yokota
- Organizer
  18th Annual Meeting of the Oligonucleotide Therapeutics Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21882
[Presentation] in vitro cytotoxicity assay of antisense oligonucleotides to predict CNS -toxicity in vivo.2022
- Author(s)
  Maho Katsuyama, Kotaro Yoshioka, Chunyan Jia, Su Su Lei Mon, Taiki Matsubayashi, Kie Tanaka, Tetsuya Nagata, Takanori Yokota.
- Organizer
  Neuro2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21882
[Presentation] AMPA-receptor-related mechanism of neurotoxicity by antisense oligonucleotides via CSF-route.2022
- Author(s)
  Kotaro Yoshioka, Chunyan Jia, Su Su Lei Mon, Maho Katsuyama, Yang Ying, Taiki Matsubayashi, Kie Tanaka-Yoshida, Tetsuya Nagata, Takanori Yokota
- Organizer
  Neuro2022.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21882
[Presentation] A novel structure of oligonucleotide improves efficacy and mitigates acute CNS toxicity via intracerebroventricular administration in mice.2022
- Author(s)
  Su Su Lei Mon, Kotaro Yoshioka, Jia Chunyan, Taiki Kunieda, Yutaro Asami, Kie Tanaka, Piao Wenying, Hiroya Kuwahara, Kazutaka Nishina, Tetsuya Nagata, Takanori Yokota
- Organizer
  18th Annual Meeting of the Oligonucleotide Therapeutics Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21882
[Presentation] 革新的な活性・安全性を有するヘテロ2本鎖核酸医薬の開発.2022
- Author(s)
  吉岡耕太郎
- Organizer
  日本薬学会関東支部第15回若手シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20K21882
[Presentation] Acute neurotoxicity by antisense oligonucleotides via CSF-route mediated by change of intracellular calcium level.2022
- Author(s)
  Kotaro Yoshioka, Chunyan Jia, Su Su Lei Mon, Maho Katsuyama, Kie Tanaka, Tetsuya Nagata, Takanori Yokota.
- Organizer
  18th Annual Meeting of the Oligonucleotide Therapeutics Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21882
[Presentation] 核酸医薬における急性神経毒性メカニズムの解明及び克服法開発.2022
- Author(s)
  吉岡耕太郎、Chunyan Jia、Su Su Lei Mon、勝山真帆、Yang Ying、松林泰毅、田中規恵、永田哲也、横田隆徳.
- Organizer
  第40回日本神経治療学会学術集会
- Data Source
  KAKENHI-PROJECT-20K21882
[Presentation] 神経毒性の軽減を可能にした新規ヘテロ2本鎖核酸医薬技術2022
- Author(s)
  吉岡耕太郎
- Organizer
  日本神経学会第63回学術大会,シンポジウム「次世代核酸医薬のサイエンス」
- Invited
- Data Source
  KAKENHI-PROJECT-20K21882
[Presentation] Heteroduplex oligonucleotide mitigates various types of acute CNS toxicities via CSF route2021
- Author(s)
  Chunyan Jia, Kotaro Yoshioka, Su Su Lei Mon, Maho Katsuyama, Kie Tanaka-Yoshida, Tetsuya Nagata, Takanori Yokota.
- Organizer
  62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K21882
[Presentation] Heteroduplex-structure reduces CNS-toxicity of ASO with intrathecal administration and enhances therapeutic index in rodents and non-human primates2021
- Author(s)
  Yoshioka K, Katsuyama M, Lei Mon SS, Jia C, Matsubayashi T, Hara R, Nagata T, Yokota T.
- Organizer
  17th Annual Meeting of the Oligonucleotide Therapeutics Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21882
[Presentation] Overhanging duplex oligonucleotides for enhanced systemic delivery2020
- Author(s)
  Yoshioka K, Kunieda T, Asami Y, Lei Mon SS, Sujino Y, Tanaka K, Piao W, Kuwahara H, Nishina K, Nagata T, Yokota T
- Organizer
  16th Annual Meeting of the Oligonucleotide Therapeutics Society. Virtual
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21882
[Presentation] 新規2本鎖核酸による遺伝子制御効果・安全性の向上および生体内核酸分子機構の解明2020
- Author(s)
  吉岡耕太郎
- Organizer
  核酸医薬シンポジウム2020
- Invited
- Data Source
  KAKENHI-PROJECT-20K21882
[Presentation] Overhanging duplex oligonucleotide with transferrin-mediated delivery2020
- Author(s)
  Kotaro Yoshioka, Taiki Kunieda, Yutaro Asami, Kie Tanaka, Wenying Piao, Hiroya Kuwahara, Kazutaka Nishina, Tetsuya Nagata, Takanori Yokota
- Organizer
  TIDES US 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21882

1. 原倫太朗 (70709766)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. 中山東城 (40613302)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 桑原宏哉 (80723486)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 東美和 (30898185)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 横田隆徳 (90231688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 内藤瑞 (50755329)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 持田祐希 (60739134)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 田村郁 (70629146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 中村乃理子 (80910174)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 新井文子 (70359678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 西尾美和子 (30623318)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. ISHIBASHI Satoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YOSHIOKA KOTARO 吉岡 耕太郎

Research Projects

Research Products

Co-Researchers

Size-tunable drug delivery systems for their application to X-ray therapy for brain tumors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脳移行促進能と核酸結合能を併せ持つ分子を用いた核酸医薬の脳内デリバリー法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a treatment for chronic active EB virus infection targeting virus-derived microRNAs

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アンチセンス核酸医薬の挑戦的脳デリバリー技術の創生Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of novel pathogenic pathways through comprehensive identification of regulatory genes for the autism transcription factor RFX

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Joint international project to establish antisense oligonucleotide therapy for treating Dentatorubral-Pallidoluysian Atrophy (DRPLA)

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

グリオーシス回避を可能とする2本鎖核酸医薬の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Overhanging duplex oligonucleotide penetrating BBBPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Change of intracellular calcium level causes acute neurotoxicity by antisense oligonucleotides via CSF route2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preferential delivery of lipid-ligand conjugated DNA/RNA heteroduplex oligonucleotide to ischemic brain in hyperacute stage2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 神経難病に対する核酸医薬品の開発2021

Author(s)

Journal Title

Data Source

[Patent] ２’－修飾ヌクレオシドを含むヘテロ核酸2022

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] ５’－シクロプロピレン修飾を含む核酸分子2022

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Patent] ｓｃｐＢＮＡ又はＡｍＮＡを含むヘテロ核酸2022

YOSHIOKA KOTARO 吉岡耕太郎