HARADA Yukihiro 原田恭弘

Researcher Number	70911402
Other IDs
Affiliation (Current)	2025: 立命館大学, 生命科学部, 助教
Affiliation (based on the past Project Information) *help	2023 – 2025: 立命館大学, 生命科学部, 助教 2021 – 2023: 国立研究開発法人国立循環器病研究センター, 研究所, リサーチフェロー
Review Section/Research Field	Principal Investigator Basic Section 48010:Anatomy-related / 0802:Biomedical structure and function and related fields Except Principal Investigator Basic Section 48010:Anatomy-related / Basic Section 52050:Embryonic medicine and pediatrics-related / Medium-sized Section 48:Biomedical structure and function and related fields / Medium-sized Section 52:General internal medicine and related fields
Keywords	Principal Investigator 内皮細胞 / 血管発生 / シグナル間相互作用 / VEGFシグナル / ALK1シグナル / SGK1 / リン酸化酵素 / 心血管発生 Except Principal Investigator 先天性心疾患 / 心血管発生 … More / 発生 / 心室筋 / 細胞系譜 / 転写制御 / 心臓 / 遺伝性血管病 / 遺伝性出血性末梢血管拡張症 / ゼブラフィッシュ / 再生医学 / 心臓ペースメーカ細胞 / エピゲノム編集 / 左心室 / 心原基 / 前駆細胞 / 分化運命 / 形態形成 / Notch/Rbpjシグナル伝達経路 / 転写 / 心筋 / エンハンサー / 細胞分化 / 胸部大血管 / ACVRL1 / 血管形成 / オスラー病 / 遺伝性出血性末梢血管拡張症（HHT） / 消化管血管形成 / ALK1シグナル / acvrl1 / 遺伝子発現制御 / 心筋細胞 / 内皮細胞 / 遺伝子組換えマウス / 先天性心血管疾患 / シグナル伝達 / 血管病 / マウス / 脈管 / 血管 Less

発生期心臓における領域特異的エンハンサーの活性制御機構と先天性心疾患における意義Principal Investigator
- Principal Investigator
  
  原田恭弘
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Ritsumeikan University
Mechanisms of cellular signaling implicated in cardiovascular development and disease
- Principal Investigator
  
  中川修
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Cardiovascular Center Research Institute
心臓ペースメーカ細胞の発生制御機構の解明とエピゲノム編集による誘導法の確立
- Principal Investigator
  
  川村晃久
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 48:Biomedical structure and function and related fields
- Research Institution
  Ritsumeikan University
心臓発生期のゲノム網羅的エンハンサーアトラスと心臓内領域特異的遺伝子発現制御機構
- Principal Investigator
  
  中川修
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  National Cardiovascular Center Research Institute
ALK1シグナルの臓器特異的血管形成における意義と難治性血管疾患の発症メカニズム
- Principal Investigator
  
  浦崎明宏
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Kobe University
  National Cardiovascular Center Research Institute
Molecular mechanisms of ALK1 signalling suppression of VEGF signalling during vascular developmentPrincipal Investigator
- Principal Investigator
  
  原田恭弘
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Ritsumeikan University
  National Cardiovascular Center Research Institute
心室筋細胞特異的な分化運命決定および転写制御機構の解明
- Principal Investigator
  
  渡邉裕介
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  National Cardiovascular Center Research Institute
Mechanisms of endothelial specific expression and downstream signaling of SGK1 protein kinase in embryonic vascular developmentPrincipal Investigator
- Principal Investigator
  
  HARADA Yukihiro
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0802:Biomedical structure and function and related fields
- Research Institution
  National Cardiovascular Center Research Institute
Downstream genes of signaling pathways implicated in human cardiovascular diseases: in vivo significance and regulatory mechanisms
- Principal Investigator
  
  中川修
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Cardiovascular Center Research Institute
Role of vascular interaction in embryonic development
- Principal Investigator
  
  Urasaki Akihiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  National Cardiovascular Center Research Institute
Molecular mechanisms of cell differentiation during development of great vessels and ventricles
- Principal Investigator
  
  Watanabe Yusuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  National Cardiovascular Center Research Institute

All 2023 2022 2021 2019

All Journal Article Presentation

[Journal Article] Computational and Experimental Analyses for Pathogenicity Prediction of ACVRL1 Missense Variants in Hereditary Hemorrhagic Telangiectasia2023
- Author(s)
  Iwasa Toru、Urasaki Akihiro、Kakihana Yuki、Nagata-Akaho Nami、Harada Yukihiro、Takeda Soichi、Kawamura Teruhisa、Shiraishi Isao、Kurosaki Kenichi、Morisaki Hiroko、Yamada Osamu、Nakagawa Osamu
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 12 Issue: 15 Pages: 5002-5002
- DOI
  10.3390/jcm12155002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15361, KAKENHI-PROJECT-22K06803, KAKENHI-PROJECT-19K08535, KAKENHI-PROJECT-21H02890
[Journal Article] Canonical Wnt signaling activation by chimeric antigen receptors for efficient cardiac differentiation from mouse embryonic stem cells2023
- Author(s)
  Sogo T, Nakao S, Tsukamoto T, Ueyama T, Harada Y, Ihara D, Ishida T, Nakahara M, Hasegawa K, Akagi Y, Kida Y, Nakagawa O, Nagamune T, Kawahara M, Kawamura T
- Journal Title
  
  Inflamm Regen
  
  Volume: 43 Issue: 1 Pages: 11-11
- DOI
  10.1186/s41232-023-00258-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06790, KAKENHI-PROJECT-21H02890, KAKENHI-PROJECT-23K21062
[Journal Article] Tmem100-BAC-EGFP mice to selectively mark and purify embryonic endothelial cells of large caliber arteries in mid-gestational vascular formation2021
- Author(s)
  Yumi Kinugasa-Katayama, Yusuke Watanabe, Takashi Hisamitsu, Yuichiro Arima, Norika M Liu, Ayaka Tomimatsu, Yukihiro Harada, Yuji Arai, Akihiro Urasaki, Teruhisa Kawamura, Yoshihiko Saito, Osamu Nakagawa
- Journal Title
  
  genesis
  
  Volume: 59 Issue: 4
- DOI
  10.1002/dvg.23416
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07280, KAKENHI-PROJECT-18H02787, KAKENHI-PROJECT-19H03398, KAKENHI-PROJECT-21H02890
[Journal Article] ETS‐dependent enhancers for endothelial‐specific expression of serum/glucocorticoid‐regulated kinase 1 during mouse embryo development2021
- Author(s)
  Harada Yukihiro, Tanaka Toru, Arai Yuji, Isomoto Yoshie, Nakano Atsushi, Nakao Shu, Urasaki Akihiro, Watanabe Yusuke, Kawamura Teruhisa, Nakagawa Osamu
- Journal Title
  
  Genes to Cells
  
  Volume: 26 Issue: 8 Pages: 611-626
- DOI
  10.1111/gtc.12874
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07280, KAKENHI-PROJECT-19H01140, KAKENHI-PROJECT-18H02787, KAKENHI-PROJECT-21K06790, KAKENHI-PROJECT-21K20751, KAKENHI-PROJECT-19H03398, KAKENHI-PROJECT-21H02890
[Presentation] 発生期の心臓内領域特異的な遺伝子発現を制御するエンハンサーの探索2023
- Author(s)
  原田恭弘、王韵策、岩瀬晃康、白井学、渡邉裕介、栗原裕基、中川修、川村晃久
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H02890
[Presentation] 発生期の心臓内領域特異的な遺伝子発現を制御するエンハンサーの探索2023
- Author(s)
  原田恭弘、王韵策、岩瀬　晃康、白井　学、渡邉　裕介、栗原　裕基、中川　修、川村晃久
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K15361
[Presentation] Physiological importance of ALK1 signaling for organotypic vascular formation2022
- Author(s)
  Akihiro URASAKI, Yuki KAKIHANA, Nami NAGATA-AKAHO, Yukihiro HARADA, Osamu NAKAGAWA
- Organizer
  第6回日本循環器学会基礎研究フォーラム
- Data Source
  KAKENHI-PROJECT-22K06803
[Presentation] Physiological importance of ALK1 signaling for organotypic vascular formation2022
- Author(s)
  Akihiro URASAKI, Yuki KAKIHANA, Nami NAGATA-AKAHO, Yukihiro HARADA, Osamu NAKAGAWA
- Organizer
  第6回日本循環器学会基礎研究フォーラム
- Data Source
  KAKENHI-PROJECT-21H02890
[Presentation] Physiological significance of ALK1 signaling in zebrafish organotypic vascular formation2021
- Author(s)
  Akihiro Urasaki, Nami Akaho Nagata, Yuki Kakihana, Yukihiro Harada, Osamu Nakagawa
- Organizer
  BCVR 第5回日本循環器学会基礎研究フォーラム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07280
[Presentation] SGK1リン酸化酵素の胎生期血管内皮特異的エンハンサー探索と活性制御機構解析2021
- Author(s)
  原田恭弘、田中亨、荒井勇二、浦﨑明宏、渡邉裕介、川村晃久、中川修
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K20751
[Presentation] ACVRL1変異と受容体分子機能の関連解析2021
- Author(s)
  岩朝徹、長田菜美、原田恭弘、垣花優希、浦﨑明宏、白石公、黒嵜健一、森崎裕子、小宮山雅樹、中川修
- Organizer
  HHT JAPAN 2021
- Data Source
  KAKENHI-PROJECT-19K07280
[Presentation] Physiological significance of ALK1 signaling in zebrafish organotypic vascular formation2021
- Author(s)
  Akihiro URASAKI, Nami NAGATA-AKAHO, Yuki KAKIHANA, Yukihiro HARADA, Osamu NAKAGAWA
- Organizer
  第5回日本循環器学会基礎研究フォーラム
- Data Source
  KAKENHI-PROJECT-21H02890
[Presentation] SGK1リン酸化酵素の胎生期血管内皮特異的エンハンサー探索と活性制御機構解析2021
- Author(s)
  原田恭弘、田中亨、荒井勇二、浦﨑明宏、渡邉裕介、川村晃久、中川修
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07280
[Presentation] ACVRL1変異と受容体分子機能の関連解析2021
- Author(s)
  岩朝徹、長田菜美、原田恭弘、垣花優希、浦﨑明宏、白石公、黒嵜健一、森崎裕子、小宮山雅樹、中川修
- Organizer
  第57回日本小児循環器学会学術集会併催第24回日本小児心血管分子医学研究会
- Data Source
  KAKENHI-PROJECT-19K07280
[Presentation] SGK1リン酸化酵素の胎生期血管内皮特異的エンハンサー探索と活性制御機構解析2021
- Author(s)
  原田恭弘、田中亨、荒井勇二、浦﨑明宏、渡邉裕介、川村晃久、中川修
- Organizer
  CVMW2021
- Data Source
  KAKENHI-PROJECT-21K20751
[Presentation] SGK1リン酸化酵素の胎生期血管内皮特異的エンハンサー探索と活性制御機構解析2021
- Author(s)
  原田恭弘、田中亨、荒井勇二、浦﨑明宏、渡邉裕介、川村晃久、中川修
- Organizer
  CVMW2021
- Data Source
  KAKENHI-PROJECT-19K07280
[Presentation] SGK1リン酸化酵素の胎生期血管内皮特異的エンハンサー探索と活性制御機構解析2021
- Author(s)
  原田恭弘、田中亨、荒井勇二、浦﨑明宏、渡邉裕介、川村晃久、中川修
- Organizer
  第25回日本心血管内分泌代謝学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02890
[Presentation] SGK1リン酸化酵素の胎生期血管内皮特異的エンハンサー探索と活性制御機構解析2021
- Author(s)
  原田恭弘、田中亨、荒井勇二、浦﨑明宏、渡邉裕介、川村晃久、中川修
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H02890
[Presentation] 胎生期血管形成におけるリン酸化酵素遺伝子SGK1の内皮特異的発現機構と下流シグナル伝達様式の解析2019
- Author(s)
  原田恭弘、田中亨、足立淳、若林真樹、石濱泰、渡邉裕介、川村晃久、中川修
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H03398
[Presentation] 胚発生における心血管シグナル伝達系と環境因子の相互関係2019
- Author(s)
  浦﨑明宏、田中亨、原田恭弘、劉孟佳、川村晃久、渡邉裕介、中川修
- Organizer
  第23回日本心血管内分泌代謝学会
- Data Source
  KAKENHI-PROJECT-19H03398
[Presentation] 胚発生における心血管シグナル伝達系と環境因子の相互関係2019
- Author(s)
  浦﨑明宏、田中亨、原田恭弘、劉孟佳、川村晃久、渡邉裕介、中川修
- Organizer
  第23回日本心血管内分泌代謝学会
- Data Source
  KAKENHI-PROJECT-19K07280
[Presentation] BMP-ALK1シグナル伝達系の新規下流遺伝子群の発現制御と機能解析2019
- Author(s)
  浦﨑明宏、渡邉裕介、原田恭弘、田中亨、劉孟佳、中川修
- Organizer
  第6回日本HHT研究会
- Data Source
  KAKENHI-PROJECT-19K07280
[Presentation] BMP-ALK1シグナル伝達系の新規下流遺伝子群の発現制御と機能解析2019
- Author(s)
  浦﨑明宏、渡邉裕介、原田恭弘、田中亨、劉孟佳、中川修
- Organizer
  第6回日本HHT研究会
- Data Source
  KAKENHI-PROJECT-19H03398

1. 中川修 (40283593)

# of Collaborated Projects: 7 results

# of Collaborated Products: 18 results
2. 橋本大輝 (40911342)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. Urasaki Akihiro (40550083)

# of Collaborated Projects: 5 results

# of Collaborated Products: 6 results
4. Watanabe Yusuke (20562333)

# of Collaborated Projects: 5 results

# of Collaborated Products: 12 results
5. 垣花優希 (40910534)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
6. LAMRI LYNDA (90883984)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
7. 川村晃久 (90393199)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
8. 劉孟佳 (50826922)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
9. 能丸寛子 (30885538)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 白井学 (70294121)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 高橋篤 (50392014)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 植山萌恵 (60844280)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. 岩朝徹 (80712843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 白石公 (80295659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 小柴和子 (30467005)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 瀬谷大貴 (30806021)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 田中亨 (50806065)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
18. 八代健太 (60432506)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. NAKAO Shu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HARADA Yukihiro 原田 恭弘

Research Projects

Research Products

Co-Researchers

発生期心臓における領域特異的エンハンサーの活性制御機構と先天性心疾患における意義Principal Investigator

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Molecular mechanisms of ALK1 signalling suppression of VEGF signalling during vascular developmentPrincipal Investigator

Principal Investigator

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Principal Investigator

Project Period (FY)

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Mechanisms of endothelial specific expression and downstream signaling of SGK1 protein kinase in embryonic vascular developmentPrincipal Investigator

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[Journal Article] Computational and Experimental Analyses for Pathogenicity Prediction of ACVRL1 Missense Variants in Hereditary Hemorrhagic Telangiectasia2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Canonical Wnt signaling activation by chimeric antigen receptors for efficient cardiac differentiation from mouse embryonic stem cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tmem100-BAC-EGFP mice to selectively mark and purify embryonic endothelial cells of large caliber arteries in mid-gestational vascular formation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ETS‐dependent enhancers for endothelial‐specific expression of serum/glucocorticoid‐regulated kinase 1 during mouse embryo development2021

Author(s)

Journal Title

HARADA Yukihiro 原田恭弘