OSHIMA Nobuhiro 大島伸宏

Researcher Number	80508648
Affiliation (based on the past Project Information) *help	2012 – 2023: 北海道医療大学, 薬学部, 助教 2008 – 2009: Health Sciences University of Hokkaido, 薬学部, 助教
Review Section/Research Field	Principal Investigator Radiation science / Basic Section 52040:Radiological sciences-related Except Principal Investigator Radiation science
Keywords	Principal Investigator 腎臓 / オクトレオチド / 放射性医薬品 / アイソトープ内用療法 / がん / インジウム-111 / ペプチド / イットリウム-90 / 腫瘍 / 体内動態 … More / octreotide / 副作用低減 / 負電荷導入 / 薬物動態制御 / ソマトスタチン受容体 / 内照射療法 / 金属錯体 / 内照射治療 / Theraostics / 内用療法 / Theranostics / インジウム / 腫瘍集積 / アイソトープ治療 / ソマトスタチン / 薬物動態 / 体内動態制御 / 薬物体内動態制御 / オクトレオチ … More Except Principal Investigator 放射線 / 薬学 / がんのイメージング / がんイメージング / 細胞周期制御因子 / サイクリン依存性キナーゼ / CDK2 / がんのイメジング / プリン受容体 / 分子イメージング / マクロファージ / 炎症 Less

Theranosticsの精度と内照射療法時の安全性を向上する放射性薬剤の開発Principal Investigator
- Principal Investigator
  
  大島伸宏
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Health Sciences University of Hokkaido
Development of a radioactive probe targeting the cell cycle regulatory factor CDK2
- Principal Investigator
  
  Kitaura Hirotake
- Project Period (FY)
  2017 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Health Sciences University of Hokkaido
Development of new radioisotope-labeled peptides for effective delivery in cancer therapyPrincipal Investigator
- Principal Investigator
  
  Oshima Nobuhiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Health Sciences University of Hokkaido
Development of 125I-labeled probe for the detection of macrophage-like cells in inflammatory lesion
- Principal Investigator
  
  Kawashima Hidekazu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Kyoto Pharmaceutical University
Development of a new radioisotope-labeled peptide with accomplished low nephrotoxicity and effectiveness in cancer therapyPrincipal Investigator
- Principal Investigator
  
  OSHIMA Nobuhiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Health Sciences University of Hokkaido
Development of radioisotope-labeled peptides of decreased renal accumulation for cancer therapyPrincipal Investigator
- Principal Investigator
  
  OSHIMA Nobuhiro
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Radiation science
- Research Institution
  Health Sciences University of Hokkaido

All 2020 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Patent

[Journal Article] 111In-DTPA-D-Phe-1-Asp0-D-Phe1-octreotide exhibits higher tumor accumulation and lower renal radioactivity than 111In-DTPA-D-Phe1-octreotide2017
- Author(s)
  Nobuhiro Oshima, Hiromichi Akizawa, Hirotake Kitaura, Hidekazu Kawashima, Songji Zhao, Yan Zhao, Ken-ichi Nishijima, Yoji Kitamura, Yasushi Arano, Yuji Kuge, Kazue Ohkura
- Journal Title
  
  Nuclear Medicine and Biology
  
  Volume: 54 Pages: 18-26
- DOI
  10.1016/j.nucmedbio.2017.07.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19810
[Journal Article] Redesign of negatively charged 111In-DTPA-octreotide derivative to reduce renal radioactivity2017
- Author(s)
  Oshima N., Akizawa H., Kawashima H., Zhao S., Zhao Y., Nishijima K. I., Kitamura Y., Arano Y., Kuge Y. and Ohkura K.
- Journal Title
  
  Nuclear medicine and biology
  
  Volume: 48 Pages: 16-25
- DOI
  10.1016/j.nucmedbio.2017.01.006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09886, KAKENHI-PROJECT-15K19810, KAKENHI-PROJECT-16K10335
[Journal Article] Design, synthesis and biological evaluation of negatively charged 111In-DTPA-octreotide derivatives2014
- Author(s)
  Oshima N, Akizawa H, Zhao S, Nishijima K, Kitamura Y, Arano Y, Kuge Y, Ohkura K
- Journal Title
  
  Bioorgan Med Chem
  
  Volume: 22 Issue: 4 Pages: 1377-1382
- DOI
  10.1016/j.bmc.2013.12.063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591742, KAKENHI-PROJECT-24591812, KAKENHI-PROJECT-24791329
[Patent] オクトレオチド類似体及びそれを用いた放射性画像診断剤2013
- Inventor(s)
  大島伸宏、秋澤宏行、大倉一枝、他4名
- Industrial Property Rights Holder
  大島伸宏、秋澤宏行、大倉一枝、他4名
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-194032
- Filing Date
  2013-09-19
- Data Source
  KAKENHI-PROJECT-24791329
[Presentation] 111In-DTPA-AA－1-Asp0-D-Phe1-octreotide 誘導体の構造と細胞取込との相関研究2020
- Author(s)
  中川原諒、大島伸宏、中上詩穂、近江悠、近藤史博、北浦廣剛、秋澤宏行
- Organizer
  日本薬学会　第140年会
- Data Source
  KAKENHI-PROJECT-18K07687
[Presentation] 111In-DTPA-L-Phe－1-Asp0-D-Phe1-octreotide の担がんマウスにおける体内動態の評価2020
- Author(s)
  大島伸宏、鹿内浩樹、亀山裕司、北浦廣剛、秋澤宏行
- Organizer
  日本薬学会　第140年会
- Data Source
  KAKENHI-PROJECT-18K07687
[Presentation] Theranostics への応用を目指した 111In-1B4M-DTPA (tiuxetan) 結合オクトレオチド誘導体の in vitro 腫瘍集積性および体内動態の評価2020
- Author(s)
  中上詩穂、大島伸宏、鹿内浩樹、斯波将司、中川原諒、山本亘汰、斉藤諒、北浦廣剛、秋澤宏行
- Organizer
  日本薬学会　第140年会
- Data Source
  KAKENHI-PROJECT-18K07687
[Presentation] 注意欠如/多動性障害モデル動物SHRSP/Ezoの辺縁系D-セリン系の機能異常2020
- Author(s)
  鹿内浩樹、渡曾明希、相山友里奈、大島伸宏、平出幸子、飯塚健治、泉剛
- Organizer
  日本薬学会　第140年会
- Data Source
  KAKENHI-PROJECT-18K07687
[Presentation] 111In-DTPA-L-Phe-1-Asp0-D-Phe1-octreotide の正常マウスでの体内動態および in vitro 腫瘍集積性の評価2018
- Author(s)
  大島伸宏, 亀山裕司, 鹿内浩樹, 北浦廣剛, 秋澤宏行, 大倉一枝
- Organizer
  日本薬学会　第138年会
- Data Source
  KAKENHI-PROJECT-15K19810
[Presentation] New 111In-labeled octreotide derivatives with increased specific tumor uptake2017
- Author(s)
  Nobuhiro Oshima
- Organizer
  CIS Workshop 2017 2nd
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19810
[Presentation] 111In-DTPA-D-Phe－1-Asp0-D-Phe1-octreotide の高い腫瘍集積性の原因解明に向けた N 末端伸長 octreotide の構活性相関研究2016
- Author(s)
  大島伸宏, 近江悠, 近藤史博, 河嶋秀和, 秋澤宏行, 大倉一枝
- Organizer
  第16回　放射性医薬品・画像診断薬研究会
- Place of Presentation
  京都勧業館「みやこめっせ」 (京都府、京都市)
- Year and Date
  2016-10-01
- Data Source
  KAKENHI-PROJECT-15K19810
[Presentation] 111In-DTPA-オクトレオチドの錯構造に基づく幾何異性体の相互変換と受容体親和性に関する検討2015
- Author(s)
  大島伸宏、河嶋秀和、秋澤宏行、久下裕司、大倉一枝
- Organizer
  第55回　日本核医学会学術総会
- Place of Presentation
  ハイアットリージェンシー東京
- Year and Date
  2015-11-05
- Data Source
  KAKENHI-PROJECT-15K19810
[Presentation] テガフールとメトキシナフタレンとの光反応による新規付加体の生成2014
- Author(s)
  大倉一枝、秋澤宏行、菅生辰之、大島伸宏、関興一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市総合体育館
- Data Source
  KAKENHI-PROJECT-24791329
[Presentation] 90Y標識のための2-(p-aminobenzyl)-6-methyl-DTPA-結合オクトレオチド誘導体の合成2013
- Author(s)
  大島伸宏、秋澤宏行、大倉一枝
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24791329
[Presentation] [111In-DTPA-D-Phe-1-Asp0-D-Phe1]-オクトレオチドの体内動態評価: 放射能の腎集積性低減と腫瘍集積性の向上
- Author(s)
  大島伸宏, 秋澤宏行, 河嶋秀和, 趙松吉, 趙芫, 西嶋剣一, 北村陽二, 荒野泰, 久下裕司, 大倉一枝
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24791329
[Presentation] アスパラギン酸で負電荷を導入した111In-DTPA-D-Phe1-オクトレオチド誘導体の in vitro 腫瘍集積性および体内動態の評価
- Author(s)
  大島伸宏、秋澤宏行、趙松吉、趙芫、西嶋剣一、北村陽二、荒野泰、久下裕司、大倉一枝
- Organizer
  日本薬学会北海道支部 139回例会
- Place of Presentation
  北海道大学学術交流会館
- Data Source
  KAKENHI-PROJECT-24791329

1. Ohkura Kazue (60094827)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. Kawashima Hidekazu (70359438)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Kitaura Hirotake (10281817)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 久下裕司 (70321958)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 東川桂 (10756878)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 水野雄貴 (90805194)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 鹿内浩樹 (00632556)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. ZHAO CHOKICHI

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. KITAMURA Yoji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 西嶋剣一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OSHIMA Nobuhiro 大島 伸宏

Research Projects

Research Products

Co-Researchers

Theranosticsの精度と内照射療法時の安全性を向上する放射性薬剤の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a radioactive probe targeting the cell cycle regulatory factor CDK2

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of new radioisotope-labeled peptides for effective delivery in cancer therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of 125I-labeled probe for the detection of macrophage-like cells in inflammatory lesion

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a new radioisotope-labeled peptide with accomplished low nephrotoxicity and effectiveness in cancer therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of radioisotope-labeled peptides of decreased renal accumulation for cancer therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 111In-DTPA-D-Phe-1-Asp0-D-Phe1-octreotide exhibits higher tumor accumulation and lower renal radioactivity than 111In-DTPA-D-Phe1-octreotide2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Redesign of negatively charged 111In-DTPA-octreotide derivative to reduce renal radioactivity2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Design, synthesis and biological evaluation of negatively charged 111In-DTPA-octreotide derivatives2014

Author(s)

Journal Title

DOI

Data Source

[Patent] オクトレオチド類似体及びそれを用いた放射性画像診断剤2013

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Presentation] 111In-DTPA-AA－1-Asp0-D-Phe1-octreotide 誘導体の構造と細胞取込との相関研究2020

Author(s)

Organizer

Data Source

[Presentation] 111In-DTPA-L-Phe－1-Asp0-D-Phe1-octreotide の担がんマウスにおける体内動態の評価2020

Author(s)

Organizer

Data Source

[Presentation] Theranostics への応用を目指した 111In-1B4M-DTPA (tiuxetan) 結合オクトレオチド誘導体の in vitro 腫瘍集積性および体内動態の評価2020

Author(s)

Organizer

Data Source

[Presentation] 注意欠如/多動性障害モデル動物SHRSP/Ezoの辺縁系D-セリン系の機能異常2020

Author(s)

Organizer

Data Source

[Presentation] 111In-DTPA-L-Phe-1-Asp0-D-Phe1-octreotide の正常マウスでの体内動態および in vitro 腫瘍集積性の評価2018

Author(s)

OSHIMA Nobuhiro 大島伸宏

[Presentation] 111In-DTPA-D-Phe－1-Asp0-D-Phe1-octreotide の高い腫瘍集積性の原因解明に向けた N 末端伸長 octreotide の構活性相関研究2016

[Presentation] [111In-DTPA-D-Phe-1-Asp0-D-Phe1]-オクトレオチドの体内動態評価: 放射能の腎集積性低減と腫瘍集積性の向上