Irukayama Youko 入鹿山容子

… Alternative Names

Irukayama Yoko 入鹿山容子

IRUKAYAMA Yoko 入鹿山容子

人鹿山容子イルカヤマヨウコ

IRUKAYAMA-TOMOBE Yoko 入鹿山容子

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Researcher Number	90312834
Other IDs
Affiliation (Current)	2025: 千葉大学, 大学院医学研究院, 特任講師
Affiliation (based on the past Project Information) *help	2025: 千葉大学, 大学院医学研究院, 特任講師 2021 – 2024: 千葉大学, 真菌医学研究センター, 特任講師 2020: 筑波大学, 人間総合科学研究科, 講師 2016 – 2020: 筑波大学, 国際統合睡眠医科学研究機構, 研究員 2017: 筑波大学, 人間総合科学研究科, 講師 … More 2010 – 2012: 筑波大学, 分子行動科学研究コア, 研究員 2007 – 2009: 筑波大学, 大学院・人間総合科学研究科, 講師 2000 – 2001: 筑波大学, 体育科学系, 助手 Less
Review Section/Research Field	Principal Investigator General pharmacology / Basic Section 53030:Respiratory medicine-related / Basic Section 48030:Pharmacology-related / Complex systems / 体育学 Except Principal Investigator Basic Section 53030:Respiratory medicine-related / Drug development chemistry / Basic Section 59040:Nutrition science and health science-related / Integrative animal science / Complex systems / Anesthesiology/Resuscitation studies / General pharmacology
Keywords	Principal Investigator DREADD / オレキシン / 生理活性 / 睡眠 / ミクログリア / 認知機能 / 全身炎症 / セボフルラン / 全身性炎症 / 脳波 … More / 敗血症 / 行動学 / 感染症 / 意志力創成 / 慢性消耗性疾患 / オレキシン受容体作動薬 / コルチコステロン / カテコールアミン / 体温 / 炎症性サイトカイン / リポポリサッカライド / 敗血症性ショック / treadmill / microshere / redistribution of blood flow / endothelin receptor antagonist / endothelin / VO_2max / 慢性運動トレーニング / NOx / トレッドミル走 / マイクロソフェアー法 / 血流再配分 / エンドセリン受容体拮抗薬 / エンドセリン-1 / 循環器・高血圧 / 高血圧 / 循環器 / ストレス … More Except Principal Investigator 睡眠 / オレキシン / 覚醒 / GABA / ナルコレプシー / オレキシン受容体 / ナルフラフィン / 有機合成化学 / 創薬化学 / OX2R作動薬 / OX1R拮抗薬 / モルフィナン骨格 / OX1R作動薬 / 拮抗薬 / 作動薬 / モルヒナン / オピオイド / オレキシン受容体作動薬 / 遺伝子 / 疾患モデル / 心室性不整脈 / 臨床心臓学 / マウス / 遺伝性 / 突然死 / 不整脈 / 教育学 / 心理学 / 精神医学 / 脳・神経 / 現代うつ / 環境 / モチベーション / 実行系 / 実行機能 / 内発的動機付け / 脳機能 / ドーパミン / スポーツ科学 / 教育心理 / ひきこもり / 報酬系 / 前頭前野 / やる気 / 意志力 / GAVA / セロトニン / ペプチド / パッチクランプ / トランスジェニックマウス / 睡眠覚醒 / バソブレッシン / 生理活性物質 / アセチルコリン / TRH / パソプレッシン Less

睡眠・覚醒リズム調整が全身性炎症による肺傷害を改善する効果と分子機構の解明Principal Investigator
- Principal Investigator
  
  入鹿山容子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Chiba University
低酸素下での呼吸調節に関わる睡眠関連物質の役割
- Principal Investigator
  
  堀内大
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Chiba University
Elucidation of molecular mechanism of cognitive dysfunction associated with sepsis and approach to new therapeutic agentsPrincipal Investigator
- Principal Investigator
  
  入鹿山容子
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Chiba University
  University of Tsukuba
Elucidation of metabolic rhythm regulation by orexin agonist
- Principal Investigator
  
  Fukusumi Shoji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  University of Tsukuba
Elucidation about roles of orexin receptor agonists on the immobility and lethargy in inflammatory model mice and approaches to new drug discoveryPrincipal Investigator
- Principal Investigator
  
  入鹿山容子
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  University of Tsukuba
Elucidation of molecular mechanism of orexin on the brain in endotoxin shockPrincipal Investigator
- Principal Investigator
  
  Irukayama Yoko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  University of Tsukuba
Creation and Promotion of Willdynamics
- Principal Investigator
  
  Sakurai Takeshi
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  University of Tsukuba
Elucidation of molecular mechanisms of spontaneous sudden cardiac death model mouse due to ventricular arrhythmia
- Principal Investigator
  
  Aonuma Kazutaka
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Integrative animal science
- Research Institution
  University of Tsukuba
Development of novel orexin ligand and its pharmacological activity
- Principal Investigator
  
  Nagase Hiroshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  University of Tsukuba
Effects of Neuropeptide W, and B on autonomic nervous systemPrincipal Investigator
- Principal Investigator
  
  IRUKAYAMA Yoko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  University of Tsukuba
Roles of orexin-producing neurons in awakening from anesthesia : Analyses using various genetically-modified mice
- Principal Investigator
  
  TAKAHASHI Hiroshi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  University of Tsukuba
Roles of orexins in regulation of sleep/wake states
- Principal Investigator
  
  MATSUZAKI Ichiyo
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General pharmacology
- Research Institution
  University of Tsukuba
ROLES BIOACTIVE PEPTIDE IN EXERCISE-INDUCED REDISTRIBUTION OF TISSUE BLOOD FLOW OF INTERNAL ORGANS AND MUSCLESPrincipal Investigator
- Principal Investigator
  
  IRUKAYAMA-TOMOBE Yoko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  体育学
- Research Institution
  Department of Sports Medicine, Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan

All 2023 2022 2021 2020 2019 2018 2017 2016 2012 2009

All Journal Article Presentation Patent

[Journal Article] Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring2022
- Author(s)
  Keita Iio, Tsuyoshi Saitoh, Ryuichiro Ohshita, Tsubasa Hino, Mao Amezawa, Yoshiaki Takayama, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kustumura, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 60 Pages: 128555-128555
- DOI
  10.1016/j.bmcl.2022.128555
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-21H05111, KAKENHI-PROJECT-20H03361, KAKENHI-PROJECT-19K07314
[Journal Article] Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton2022
- Author(s)
  Tsubasa Hino, Tsuyoshi Saitoh, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kutsumura, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 59 Pages: 128530-128530
- DOI
  10.1016/j.bmcl.2022.128530
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-21H05111, KAKENHI-PROJECT-20H03361, KAKENHI-PROJECT-19K07314
[Journal Article] Effect of sevoflurane preconditioning on sleep reintegration after alteration by lipopolysaccharide2022
- Author(s)
  Nemoto Tsuyoshi、Irukayama‐Tomobe Yoko、Hirose Yuki、Tanaka Hiromu、Takahashi Genki、Takahashi Satoshi、Yanagisawa Masashi、Kanbayashi Takashi
- Journal Title
  
  Journal of Sleep Research
  
  Volume: - Issue: 5 Pages: 1-11
- DOI
  10.1111/jsr.13556
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08037, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-19K07314
[Journal Article] Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) librasy2022
- Author(s)
  Saitoh T, Amezawa M, Horiuchi J, Nagumo Y, Yamamoto N, Kutsumura N, Ohshita R, Tokuda A, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Hasegawa E, Sakurai T, Uchida Y, Sato T, Gouda H, Tanimura R, Yanagisawa M, Nagase H.
- Journal Title
  
  Eur J Med Chem
  
  Volume: 240 Pages: 114505-27
- DOI
  10.1016/j.ejmech.2022.114505
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07314, KAKENHI-PROJECT-22H04918, KAKENHI-ORGANIZER-21H05111, KAKENHI-PROJECT-20H03361
[Journal Article] Effect of removal of the 14-hydroxy group on the affinity of the 4,5-epoxymorphinan derivatives for orexin and opioid receptors2022
- Author(s)
  Katoh Koki、Yamamoto Naoshi、Ishikawa Yukiko、Irukayama-Tomobe Yoko、Tanimura Ryuji、Saitoh Tsuyoshi、Nagumo Yasuyuki、Kutsumura Noriki、Yanagisawa Masashi、Nagase Hiroshi
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 59 Pages: 128527-128527
- DOI
  10.1016/j.bmcl.2022.128527
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05710, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-19K07314
[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in d-nor-nalfurafine derivatives2022
- Author(s)
  Katoh Koki、Kutsumura Noriki、Yamamoto Naoshi、Nagumo Yasuyuki、Saitoh Tsuyoshi、Ishikawa Yukiko、Irukayama-Tomobe Yoko、Tanimura Ryuji、Yanagisawa Masashi、Nagase Hiroshi
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 59 Pages: 128550-128550
- DOI
  10.1016/j.bmcl.2022.128550
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05710, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-19K07314
[Journal Article] OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of nalcolepsy2022
- Author(s)
  Yamamoto H, Nagumo Y, Ishikawa Y, Irukayama-Tomobe Y, Namekawa Y, Nemoto T, Tanaka H, Takahashi G, Tokuda A, Saitoh T, Nagase H, Funato H, Yanagisawa M.
- Journal Title
  
  PLos One
  
  Volume: 17 Issue: 7 Pages: e0271901-e0271901
- DOI
  10.1371/journal.pone.0271901
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07314, KAKENHI-PROJECT-22K19410, KAKENHI-PROJECT-22H04918, KAKENHI-PROJECT-20H00567
[Journal Article] Design　and　synthesis　of　novel　orexin　antagonists via structural simplification of the morphinan skeleton.2021
- Author(s)
  Ohrui S, Irukayama-Tomobe Y, Ishikawa　Y,　Yanagisawa　M,　and　Nagase　 H.
- Journal Title
  
  Heterocycles
  
  Volume: - Issue: 2 Pages: 929-929
- DOI
  10.3987/com-20-s(k)63
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07314, KAKENHI-PROJECT-20K15965, KAKENHI-PROJECT-18K11014
[Journal Article] Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine2020
- Author(s)
  Nagumo Yasuyuki、Katoh Koki、Iio Keita、Saitoh Tsuyoshi、Kutsumura Noriki、Yamamoto Naoshi、Ishikawa Yukiko、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Baba Takeshi、Tanimura Ryuji、Yanagisawa Masashi、Nagase Hiroshi
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 30 Issue: 17 Pages: 127360-127360
- DOI
  10.1016/j.bmcl.2020.127360
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05710, KAKENHI-PROJECT-19K07314, KAKENHI-PROJECT-18K11014, KAKENHI-ORGANIZER-15H05935, KAKENHI-WRAPUP-20H05615
[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring2019
- Author(s)
  Yamamoto Naoshi、Ohrui Sayaka、Okada Takahiro、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 27 Issue: 8 Pages: 1747-1758
- DOI
  10.1016/j.bmc.2019.03.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-18K11014, KAKENHI-PROJECT-19K07314, KAKENHI-PROJECT-18K14352, KAKENHI-PROJECT-16H05098
[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity.2019
- Author(s)
  Saitoh T, Seki K, Nakajima R, Yamamoto N, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Tanimura R, Yanagisawa M, Nagase H.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 29 Issue: 18 Pages: 2655-2658
- DOI
  10.1016/j.bmcl.2019.07.039
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07314, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-18K14352
[Journal Article] A Novel Rearrangement Reaction of Morphinan to Arylmorphan Skeletons and the Pharmacologies of Arylmorphan Derivatives.2019
- Author(s)
  Yata M, Kutsumura N, Nagumo Y, Yamamoto N, Saitoh T, Ishikawa Y, Irukayama-Tomobe Y, Yanagisawa M, Nagase H.
- Journal Title
  
  Heterocycles
  
  Volume: 99 Pages: 134-144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07314
[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity.2019
- Author(s)
  Saitoh T, Seki K, Nakajima R, Yamamoto N, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Tanimura R, Yanagisawa M, Nagase H.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 29 Issue: 3 Pages: 26552658-26552658
- DOI
  10.1016/j.bmcl.2019.126893
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11014, KAKENHI-PROJECT-17H06095, KAKENHI-PROJECT-18K14352
[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity2018
- Author(s)
  Ohrui Sayaka、Yamamoto Naoshi、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 28 Issue: 4 Pages: 774-777
- DOI
  10.1016/j.bmcl.2017.12.069
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-15K16557, KAKENHI-PROJECT-16H05098
[Journal Article] Development of a Therapeutic Drug for Narcolepsy2018
- Author(s)
  Yoko Irukayama-Tomobe and Masashi Yanagisawa
- Journal Title
  
  BRAIN and NERVE
  
  Volume: 70 Pages: 1255-63
- Data Source
  KAKENHI-PROJECT-16K08541
[Journal Article] Development of a Therapeutic Drug for Narcolepsy2018
- Author(s)
  Yoko Irukayama-Tomobe and Masashi Yanagisawa
- Journal Title
  
  BRAIN and NERVE
  
  Volume: 70 Pages: 1255-63
- Data Source
  KAKENHI-PUBLICLY-17H06049
[Journal Article] Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models2017
- Author(s)
  Irukayama-Tomobe Y, Ogawa Y, Tominaga H, Ishikawa Y, Hosokawa N, Ambai S, Kawabe Y, Uchida S, Nakajima R, Saitoh T, Kanda T, Vogt K, Sakurai T, Nagase H, Yanagisawa M.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 114 Issue: 22 Pages: 5731-5736
- DOI
  10.1073/pnas.1700499114
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-16H06400, KAKENHI-PROJECT-15H03122, KAKENHI-PROJECT-15K16557, KAKENHI-PROJECT-16H05098
[Journal Article] IIIS発　ナルコレプシー治療薬開発に向けた取り組み2017
- Author(s)
  斉藤毅、入鹿山容子、柳沢正史、長瀬博
- Journal Title
  
  なるこ
  
  Volume: 34 Pages: 8-10
- Data Source
  KAKENHI-PROJECT-16H05098
[Journal Article] Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor2017
- Author(s)
  Yamamoto Naoshi、Ohrui Sayaka、Okada Takahiro、Yata Masahiro、Saitoh Tsuyoshi、Kutsumura Noriki、Nagumo Yasuyuki、Irukayama-Tomobe Yoko、Ogawa Yasuhiro、Ishikawa Yukiko、Watanabe Yurie、Hayakawa Daichi、Gouda Hiroaki、Yanagisawa Masashi、Nagase Hiroshi
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 27 Issue: 17 Pages: 4176-4179
- DOI
  10.1016/j.bmcl.2017.07.011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-15K16557, KAKENHI-PROJECT-16H05098, KAKENHI-ORGANIZER-15H05935
[Journal Article] Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies2017
- Author(s)
  Nagase H and Yanagisawa M et al.
- Journal Title
  
  J Med Chem
  
  Volume: 60 Issue: 3 Pages: 1018-1040
- DOI
  10.1021/acs.jmedchem.6b01418
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-ORGANIZER-15H05935, KAKENHI-PROJECT-26220207, KAKENHI-PROJECT-16H05098, KAKENHI-PROJECT-15H06606, KAKENHI-PROJECT-15K19195, KAKENHI-PROJECT-15K16557
[Journal Article] Peripherally administered orexin improves survival of mice with endotoxin shock.2016
- Author(s)
  Ogawa Y, Irukayama-Tomobe Y, Murakoshi N, Kiyama M, Ishikawa Y, Hosokawa N, Tominaga H, Uchida S, Kimura S, Kanuka M, Morita M, Hamada M, Takahashi S, Hayashi Y, Yanagisawa M.
- Journal Title
  
  Elife.
  
  Volume: 5 Pages: 1-18
- DOI
  10.7554/elife.21055
- NAID
  120007135042
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26220207, KAKENHI-PROJECT-16K08541
[Journal Article] A Single Nucleotide Polymorphism of the Neuropeptide B/W receptor-1 GeneInfluences the Evaluation of Facial Expressions2012
- Author(s)
  Noriya Watanabe, Mari Wada, Yo ko Irukayama-Tomobe, Yousuke Ogata, Natsuko Tujino, Mika Suzuki, Naoki Furutani, Takeshi Sakurai, and Masashi Yanagisawa et.
- Journal Title
  
  PLoS ONE
  
  Volume: Vol. 7 issue 4 Pages: 1-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590236
[Journal Article] A Single Nucleotide Polymorphism of the Neuropeptide B/W receptor-1 GeneInfluences the Evaluation of Facial Expressions2012
- Author(s)
  Noriya Watanabe, Mari Wada, Yoko Irukayama-Tomobe, et.al.
- Journal Title
  
  PLoS ONE
  
  Volume: Volume 7 issue 4 Pages: 1-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590236
[Journal Article] Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor GPR109B2009
- Author(s)
  Irukayama-Tomobe, Y, Tanaka, H., Yokomizo, T., Hashidate-Yoshida, T., Yanagisawa, M., Sakurai, T.
- Journal Title
  
  Proc.Natl.Acad.,Sci.,USA. 106
  
  Pages: 3930-3934
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390402
[Journal Article] Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor GPR109B2009
- Author(s)
  Irukayama-Tomobe, Y, Tanaka, H., Yokomizo, T., Hashidate-Yoshida, T., Yanagisawa, M., Sakurai, T.
- Journal Title
  
  Proc.Natl.Acad.,Sci.,USA. 106
  
  Pages: 3930-3934
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209008
[Patent] スルホンアミド誘導体またはその薬学的に許容される酸付加塩2017
- Inventor(s)
  長瀬博、斉藤毅、柳沢正史、入鹿山容子
- Industrial Property Rights Holder
  長瀬博、斉藤毅、柳沢正史、入鹿山容子
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] スピロインダノピペリジン骨格を有する新規オレキシン1受容体選択的拮抗薬の創製と構造活性相関研究1明治薬大・2筑波大WPI-IIIS）2023
- Author(s)
  齋藤匠海、大類彩、粕谷駿介、髙梨南風、曽我茉祐、藤野彩花、田湯正法、杉原稔、石川有紀子、入鹿山容子、柳沢正史、齋藤望
- Organizer
  第５２回複素環化学討論会　2023仙台
- Data Source
  KAKENHI-PROJECT-19K07314
[Presentation] 起立性調節障害の周辺症状（睡眠覚醒）を治療してQOLを改善する2023
- Author(s)
  神林　崇、千葉　滋、補永　恭穂、白井　謙太郎、入鹿山　容子、石戸　秀明、姉川　絵美子、根本　剛、紺野　雄大、森田　恵美、木村　昌由美
- Organizer
  日本睡眠学会第45回定期学術集会2023 横浜
- Data Source
  KAKENHI-PROJECT-19K07314
[Presentation] セボフルランのプレコンディショニングは全身炎症時におけるα波・β波の回復を促進する2023
- Author(s)
  根本　剛、入鹿山-友部　容子、廣瀬　優樹、柳沢　正史、神林　崇
- Organizer
  日本麻酔科学会第70回学術集会2023 神戸
- Data Source
  KAKENHI-PROJECT-19K07314
[Presentation] 睡眠関連神経ペプチドの死戦期呼吸と上気道開大筋への効果について2023
- Author(s)
  入鹿山　容子、神　久代、泰地　紗季、根本　剛、金　俊達、濱村智哉、緒方　邑ノ典、三澤　智子、神林　崇、西野　卓、磯野　史朗、粕谷　善俊、巽　浩一郎
- Organizer
  日本薬理学会年会第97回年会　2023神戸
- Data Source
  KAKENHI-PROJECT-19K07314
[Presentation] セボフルランによるプレコンディショニングは全身炎症時におけるα波・β波の回復を促進する2023
- Author(s)
  根本剛, 入鹿山-友部容子, 廣瀬優樹 , 柳沢正史, 神林崇
- Organizer
  日本麻酔科学会第70回学術集会
- Data Source
  KAKENHI-PROJECT-19K07314
[Presentation] 吸入麻酔薬のセボフルランの前投与で全身炎症による睡眠障害の回復が促進される2022
- Author(s)
  根本剛, 入鹿山-友部容子, 廣瀬優樹, 田中大夢, 高橋元樹, 高橋敏, 柳沢正史, 神林崇
- Organizer
  日本睡眠学会第47回定期学術集会
- Data Source
  KAKENHI-PROJECT-19K07314
[Presentation] Sevoflurane preconditioning promotes sleep reintegration from lipopolysaccharide induced shattered sleep2022
- Author(s)
  Tsuyoshi Nemoto, Yoko Irukayama-Tomobe, Yuki Hirose, HiromuTanaka, GenkiTakahashi, Satoshi Takahashi, Masashi Yanagisawa, Takashi Kanbayashi
- Organizer
  SLEEP 2022, the 36th annual meeting of the Associated Professional Sleep Societies,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07314
[Presentation] Enhancement in sleep recovery during systemic inflammation is potentiated by sevoflurane preconditioning2022
- Author(s)
  Tsuyoshi Nemoto, Yoko Irukayama-Tomobe, Yuki Hirose, HiromuTanaka, GenkiTakahashi, Satoshi Takahashi, Masashi Yanagisawa, Takashi Kanbayashi
- Organizer
  第99回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-19K07314
[Presentation] 全身炎症時の睡眠回復におけるセボフルランによるプレコンディショニングの効果2022
- Author(s)
  根本剛，入鹿山-友部容子，廣瀬優樹，高橋敏，柳沢正史，神林崇
- Organizer
  日本麻酔科学会第69回学術集会
- Data Source
  KAKENHI-PROJECT-19K07314
[Presentation] OX2R-selective orexin agonism is sufficient to ameliorate narcoleptic symptoms, cataplexy and sleep/wakefulness fragmentation in mouse models.2020
- Author(s)
  Yamamoto H, Irukayama-Tomobe Y, Ishikawa Y, Namekawa Y, Nemoto T, Tanaka H, Takahashi G, Yanagisawa M.
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K11014
[Presentation] OX2R-selective orexin agonism is sufficient to ameliorate narcoleptic symptoms, cataplexy and sleep/wakefulness fragmentation in mouse models2020
- Author(s)
  Yamamoto H, Irukayama-Tomobe Y, Ishikawa Y, Namekawa Y, Nemoto T, Tanaka H, Takahashi G, Yanagisawa M.
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07314
[Presentation] OX2R-selective orexin agonism is sufficient to ameliorate narcoleptic symptoms, cataplexy and sleep/wakefulness fragmentation in mouse models.2020
- Author(s)
  Yamamoto H, Irukayama-Tomobe Y, Ishikawa Y, Namekawa Y, Nemoto T, Tanaka H, Takahashi G, Yanagisawa M.
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07314
[Presentation] In vitro and in vivo pharmacology of small-molecule orexin agonists for treatment of narcolepsy2019
- Author(s)
  1.Namekawa Y, Irukayama-Tomobe Y, Ishikawa Y, Yamaguchi T, Ogawa Y, Nemoto T, Tanaka H, Yamamoto H, Tito Akindele, Saitoh T, Nagase H, Yanagisawa M
- Organizer
  Tsukuba Global Science Week
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11014
[Presentation] PERO: A stress-free, quantitative oral administration method through voluntary licking behavior2019
- Author(s)
  高橋　恵理矢、榎本　杏子、滑川　由紀子、入鹿山　容子、柳沢　正史
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07314
[Presentation] 自発的なめ行動による即時的かつ定量的なストレスフリー経口投与法 (PERO法) の確立2019
- Author(s)
  高橋恵理矢、榎本杏子、滑川由紀子、入鹿山容子、柳沢正史
- Organizer
  第92回　日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-16K08541
[Presentation] In vitro and in vivo pharmacology of YNT-X, a novel small-molecule orexin type 2 receptor agonist2019
- Author(s)
  滑川由紀子、入鹿山　容子、小川　靖裕、石川　有紀子、山口　拓土、アキンデレ　チト、斎藤　毅、長瀬　博、柳沢　正史
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07314
[Presentation] Essential structure of orexin 1 receptor antagonist YNT-7072019
- Author(s)
  Ohrui S, Yamamoto N, Okada T, Yata M, Saitoh T, Kutsumura N, Nagumo N, Irukayama-Tomobe Y, Ishikawa Y, Ogawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H.
- Organizer
  27th International Society of Heterocyclic Chemistry Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07314
[Presentation] 新規低分子量オレキシン2型受容体作動薬、YNT-Xの薬理作用2019
- Author(s)
  滑川由紀子、入鹿山容子、小川靖裕、石川由紀子、山口拓土、アキンデレ　チト、斉藤毅、長瀬博、柳沢正史
- Organizer
  第92回　日本薬理学会年会
- Data Source
  KAKENHI-PUBLICLY-17H06049
[Presentation] 新規低分子量オレキシン2型受容体作動薬、YNT-Xの薬理作用2019
- Author(s)
  滑川由紀子、入鹿山容子、小川靖裕、石川由紀子、山口拓土、アキンデレ　チト、斉藤毅、長瀬博、柳沢正史
- Organizer
  第92回　日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-16K08541
[Presentation] Discovery of Novel Orexin Receptor Antagonist with 1,3,5-Trioxazatriquinane Skeleton2019
- Author(s)
  Amezawa M, Horiuchi J, Saitoh T, Ogawa Y, Ishikawa Y, Irukayama Y, Hasegawa E, Hayakawa D, Watanabe Y, Nagumo Y, Yamamoto N, Kutsumura N, Gouda H, Sakurai T, Yanagisawa M, Nagase H.
- Organizer
  The 27th French-Japanese Symposium on Medicinal and Fine Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07314
[Presentation] In vitro and in vivo pharmacology of small-molecule orexin agonists for treatment of narcolepsy2019
- Author(s)
  Namekawa Y, Irukayama-Tomobe Y, Ishikawa Y, Yamaguchi T, Ogawa Y, Nemoto T, Tanaka H, Yamamoto H, Tito Akindele, Saitoh T, Nagase H, Yanagisawa M
- Organizer
  Tsukuba Global Science Week (TGSW)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07314
[Presentation] 自発的なめ行動による即時的かつ定量的なストレスフリー経口投与法 (PERO法) の確立2019
- Author(s)
  高橋恵理矢、榎本杏子、滑川由紀子、入鹿山容子、柳沢正史
- Organizer
  第92回　日本薬理学会年会
- Data Source
  KAKENHI-PUBLICLY-17H06049
[Presentation] Discovery of Novel Orexin Receptor Antagonist with 1,3,5-Trioxazatriquinane Skeleton2019
- Author(s)
  3.Amezawa M, Horiuchi J, Saitoh T, Ogawa Y, Ishikawa Y, Irukayama Y, Hasegawa E, Hayakawa D, Watanabe Y, Nagumo Y, Yamamoto N, Kutsumura N, Gouda H, Sakurai T, Yanagisawa M, Nagase H.
- Organizer
  The 27th French-Japanese Symposium on Medicinal and Fine Chemistry Hotel Leopalace Hakata
- Data Source
  KAKENHI-PROJECT-18K11014
[Presentation] Essential structure of orexin 1 receptor antagonist YNT-7072019
- Author(s)
  2.Ohrui S, Yamamoto N, Okada T, Yata M, Saitoh T, Kutsumura N, Nagumo N, Irukayama-Tomobe Y, Ishikawa Y, Ogawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H.
- Organizer
  27th International Society of HeterocyclicChemistry Congress ROHM Theatre Kyoto & Miyakomesse
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11014
[Presentation] 1,3,5-Trioxazatriquinane骨格を有するトリマーの合成とオレキシン受容体拮抗活性評価2018
- Author(s)
  雨澤真櫻、堀内淳平、斉藤毅、大下隆一郎、石川有紀子、入鹿山容子、小川靖裕、長谷川恵美、南雲康行、山本直司、沓村憲樹、早川大地、渡邉友里江、合田浩明、櫻井武、柳沢正史、長瀬博
- Organizer
  薬学会関東部会
- Data Source
  KAKENHI-PROJECT-16K08541
[Presentation] Orexin agonist improves inflammation-induced immobility2018
- Author(s)
  Shuntaro Uchida, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Takuto Yamaguchi, Katsuyasu Sakurai, Shingo Soya, Tsuyoshi Saito, Hiroshi Nagase, Masashi Yanagisawa, Takeshi Sakurai
- Organizer
  WCP 2018, 18th World Congress of Basic and Clinical Pharmacology（第18回　国際薬理学・臨床薬理学会議）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08541
[Presentation] 単一細胞レベルでのカルシウム反応計測における最適化条件の確立2018
- Author(s)
  石川有紀子、入鹿山容子、小川靖裕、斉藤毅、長瀬博、柳沢正史
- Organizer
  日本生理学会大会
- Data Source
  KAKENHI-PUBLICLY-17H06049
[Presentation] 1,3,5-Trioxazatriquinane骨格を有するトリマーの合成とオレキシン受容体拮抗活性評価2018
- Author(s)
  雨澤真櫻、堀内淳平、斉藤毅、大下隆一郎、石川有紀子、入鹿山容子、小川靖裕、長谷川恵美、南雲康行、山本直司、沓村憲樹、早川大地、渡邉友里江、合田浩明、櫻井武、柳沢正史、長瀬博
- Organizer
  薬学会関東部会
- Data Source
  KAKENHI-PUBLICLY-17H06049
[Presentation] Orexin agonist improves inflammation-induced immobility2018
- Author(s)
  Shuntaro Uchida, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Takuto Yamaguchi, Yukiko Ishikawa, Shingo Soya, Tsuyoshi Saito, Hiroshi Nagase, Masashi Yanagisawa, Takeshi Sakurai
- Organizer
  World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H06049
[Presentation] A synthetic orexin agonist improves inflammation-induced immobility through activating the medullary raphe nucleus2018
- Author(s)
  Shuntaro Uchida, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Takuto Yamaguchi, Yukiko Ishikawa, Katsuyasu Sakurai, Shingo Soya, Tsuyoshi Saito, Hiroshi Nagase, Masashi Yanagisawa, Takeshi Sakurai
- Organizer
  Neuroscience 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08541
[Presentation] Non-peptidic Orexin receptor type-2 agonist attenuates body weight gain of high-fat fed mice”2018
- Author(s)
  Eriya Takahashi*, Kyoko Enomoto, Takuto Yamaguchi, Yasuhiro Ogawa, Shoji Fukusumi, Akari Kawai, Masaya Araki, Tsuyoshi Saitoh, Yoshimi Nakagawa,Yoko Irukayama-Tomobe, Hitoshi Shimano, Hiroshi Nagase, Masashi Yanagisawa
- Organizer
  The 41st Annual Meeting of the Japan Neuroscience Society.
- Data Source
  KAKENHI-PUBLICLY-17H06049
[Presentation] Orexin agonist improves inflammation-induced immobility2018
- Author(s)
  Shuntaro Uchida, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Takuto Yamaguchi, Katsuyasu Sakurai, Shingo Soya, Tsuyoshi Saito, Hiroshi Nagase, Masashi Yanagisawa, Takeshi Sakurai
- Organizer
  WCP 2018, 18th World Congress of Basic and Clinical Pharmacology（第18回　国際薬理学・臨床薬理学会議）
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H06049
[Presentation] A synthetic orexin agonist improves inflammation-induced immobility through activating the medullary raphe nucleus2018
- Author(s)
  Shuntaro Uchida, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Takuto Yamaguchi, Yukiko Ishikawa, Katsuyasu Sakurai, Shingo Soya, Tsuyoshi Saito, Hiroshi Nagase, Masashi Yanagisawa, Takeshi Sakurai
- Organizer
  Neuroscience 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H06049
[Presentation] Orexin agonist improves inflammation-induced immobility2018
- Author(s)
  Shuntaro Uchida, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Takuto Yamaguchi, Yukiko Ishikawa, Shingo Soya, Tsuyoshi Saito, Hiroshi Nagase, Masashi Yanagisawa, Takeshi Sakurai
- Organizer
  World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08541
[Presentation] Non-peptidic Orexin receptor type-2 agonist attenuates body weight gain of high-fat fed mice2018
- Author(s)
  1.Eriya Takahashi*, Kyoko Enomoto, Takuto Yamaguchi, Yasuhiro Ogawa, Shoji Fukusumi, Akari Kawai, Masaya Araki, Tsuyoshi Saitoh, Yoshimi Nakagawa, Yoko Irukayama-Tomobe, Hitoshi Shimano, Hiroshi Nagase, Masashi Yanagisawa
- Organizer
  The 41st Annual Meeting of the Japan Neuroscience Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11014
[Presentation] Non-peptidic Orexin receptor type-2 agonist attenuates body weight gain of high-fat fed mice2018
- Author(s)
  Eriya Takahashi*, Kyoko Enomoto, Takuto Yamaguchi, Yasuhiro Ogawa, Shoji Fukusumi, Akari Kawai, Masaya Araki, Tsuyoshi Saitoh, Yoshimi Nakagawa,Yoko Irukayama-Tomobe, Hitoshi Shimano, Hiroshi Nagase, Masashi Yanagisawa
- Organizer
  The 41st Annual Meeting of the Japan Neuroscience Society
- Data Source
  KAKENHI-PROJECT-16K08541
[Presentation] 1,3,5-Trioxazatriquinane骨格を有するトリマーの合成とオレキシン受容体拮抗活性評価2018
- Author(s)
  雨澤真櫻、堀内惇平、斉藤　毅、大下隆一郎、小川靖裕、石川有紀子、入鹿山容子、長谷川恵美、南雲康行、山本直司、沓村憲樹、早川大地、渡邉友里江、合田浩明、櫻井　武、柳沢正史、長瀬　博
- Organizer
  第62回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] 単一細胞レベルでのカルシウム反応計測における最適化条件の確立2018
- Author(s)
  石川有紀子、入鹿山容子、小川靖裕、斉藤毅、長瀬博、柳沢正史
- Organizer
  日本生理学会大会
- Data Source
  KAKENHI-PROJECT-16K08541
[Presentation] Optimization of experimental conditions in intracellular calcium mobilization measurement at the single cell level2017
- Author(s)
  Yukiko Ishikawa, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Tsuyoshi Saito, Hiroshi Nagase, Masashi Yanagisawa.
- Organizer
  第95回　日本生理学会大会
- Data Source
  KAKENHI-PUBLICLY-17H06049
[Presentation] A small molecule orexin receptor agonist promotes recovery from inflammation-induced immobility2017
- Author(s)
  内田　俊太郎、入鹿山　容子、小川　靖裕、富永　拡、石川　ゆい、木山　麻衣子、斉藤　毅、長瀬　博、柳沢　正史
- Organizer
  薬理学会年会（第90回）
- Place of Presentation
  長崎ブリックホール(長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16K08541
[Presentation] 低分子量オレキシン受容体2型作動薬YNT-185の組織学的、及び電気生理学的解析2017
- Author(s)
  小川　靖裕、入鹿山　容子、富永　拡、細川　直人、斉藤　毅、長瀬　博、柳沢　正史
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎新聞文化ホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] Orexin agonist improves inflammation-induced immobility2017
- Author(s)
  Shuntaro Uchida, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Takuto Yamaguchi, Yukiko Namekawa, Ryo Fukai, Tsuyoshi Nemoto, Hiromu Tominaga, Yukiko Ishikawa, Katsuyasu Sakurai, Shingo Soya, Tsuyoshi Saito, Hiroshi Nagase, Masashi Yanagisawa, Takeshi Sakurai.
- Organizer
  The 6th Annual IIIS Symposium
- Data Source
  KAKENHI-PROJECT-16K08541
[Presentation] Orexin agonist improves inflammation-induced immobility2017
- Author(s)
  Shuntaro Uchida, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Takuto Yamaguchi, Yukiko Namekawa, Ryo Fukai, Tsuyoshi Nemoto, Hiromu Tominaga, Yukiko Ishikawa, Katsuyasu Sakurai, Shingo Soya, Tsuyoshi Saito, Hiroshi Nagase, Masashi Yanagisawa, Takeshi Sakurai.
- Organizer
  The 6th Annual IIIS Symposium
- Data Source
  KAKENHI-PUBLICLY-17H06049
[Presentation] キャップトリマー骨格を有するオレキシン受容体拮抗薬の設計・合成12017
- Author(s)
  堀内惇平、大下隆一郎、南雲康行、山本直司、沓村憲樹、斉藤毅、入鹿山容子、石川有紀子、小川靖裕、柳沢正史、長瀬博
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] Transgenic overexpression of orexin improves survival after myocardial infarction in mice2017
- Author(s)
  石川　ゆい、村越　伸行、入鹿山　容子、小川　靖裕、内田　俊太郎、富永　拡、田尻　和子、長瀬　博、柳沢　正史
- Organizer
  薬理学会年会（第90回）
- Place of Presentation
  長崎ブリックホール(長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16K08541
[Presentation] オレキシン高発現マウスにおける心筋梗塞の予後改善2017
- Author(s)
  石川　ゆい、村越　伸行、入鹿山　容子、小川　靖裕、内田　俊太郎、富永　拡、田尻　和子、長瀬　博、柳沢　正史
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎新聞文化ホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] オレキシン１受容体拮抗薬YNT-707の必須構造部位検討2017
- Author(s)
  大類彩、山本直司、岡田卓大、谷田誠浩、斉藤毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、渡邊友里恵、早川大地、合田浩明、柳沢正史、長瀬博
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] キャップトリマー骨格を有するオレキシン受容体拮抗薬の設計・合成22017
- Author(s)
  大下隆一郎、堀内惇平、南雲康行、山本直司、沓村憲樹、斉藤毅、入鹿山容子、石川有紀子、小川靖裕、柳沢正史、長瀬博
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] モルヒナン骨格を有するオレキシン1受容体（OX1R）の特異的拮抗薬の設計・合成とOX1R結合の活性立体配座2017
- Author(s)
  山本直司、大類彩、岡田卓大、谷田誠浩、斉藤毅、沓村憲樹、南雲康行、入鹿山容子、小川靖裕、石川有紀子、平山重人、渡辺友里恵、早川大地、合田浩明、柳沢正史、長瀬博
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] Design and synthesis of orexin 1 receptor selective antagonists2017
- Author(s)
  Sayaka Ohrui, Naoshi Yamamoto, Masahiro Yata, Takahiro Okada, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Yasuhiro Ogawa, Shigeto Hirayama, Masashi Yanagisawa, Hiroshi Nagase
- Organizer
  Tsukuba Global Science Week (TGSW) 2017
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] Histological and electrophysiological analysis of small-molecule OX2R-selective agonist YNT-1852017
- Author(s)
  小川　靖裕、入鹿山　容子、富永　拡、細川　直人、斉藤　毅、長瀬　博、柳沢　正史
- Organizer
  薬理学会年会（第90回）
- Place of Presentation
  長崎ブリックホール(長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16K08541
[Presentation] 新規低分子量オレキシン受容体作動薬YNT-185の全身炎症後の活動回復作用の検討2017
- Author(s)
  内田　俊太郎、入鹿山　容子、小川　靖裕、富永　拡、石川　ゆい、木山　麻衣子、斉藤　毅、長瀬　博、柳沢　正史
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎新聞文化ホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] 低分子オレキシン受容体アゴニストの創製2016
- Author(s)
  斉藤　毅、永原崇志、沓村憲樹、入鹿山容子、小川靖裕、富永　拡、黒田大介、合田浩明、藤井秀明、柳沢正史、長瀬　博
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学本郷キャンパス（東京都文京区）
- Year and Date
  2016-09-17
- Invited
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] Synthesis of Novel, Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton2016
- Author(s)
  Naoshi Yamamoto, Masahiro Yata, Sayaka Ohrui, Takahiro Okada, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Yasuhiro Ogawa, Daisuke Kuroda, Hiroaki Gouda, Masashi Yanagisawa, Hiroshi Nagase
- Organizer
  The 25th French-Japanese Symposium on Medicinal and Fine Chemistry
- Place of Presentation
  Keio Plaza Hotel Tama（東京都多摩市）
- Year and Date
  2016-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] モルヒナン骨格を有する新規オレキシン1受容体選択的拮抗薬の設計・合成①2016
- Author(s)
  大類　彩、山本直司、谷田誠浩、岡田卓大、斉藤　毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、柳沢正史、長瀬　博
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学本郷キャンパス（東京都文京区）
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] ナルフラフィンの構造を基にしたオレキシン1受容体選択的拮抗薬の設計・合成およびその薬理作用2016
- Author(s)
  山本直司、谷田誠浩、大類　彩、岡田卓大、斉藤　毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、平山重人、柳沢正史、長瀬　博
- Organizer
  第36回鎮痛薬・オピオイドペプチドシンポジウム
- Place of Presentation
  北海道大学（北海道札幌市）
- Year and Date
  2016-06-19
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] YNT-707のOX1Rアンタゴニスト活性発現のための必須構造の検討2016
- Author(s)
  関　知範、中嶋　龍、斉藤　毅、入鹿山容子、小川靖裕、石川有紀子、柳沢正史、長瀬　博
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] モルヒナン骨格を有する新規オレキシン1受容体選択的拮抗薬の設計・合成②2016
- Author(s)
  岡田卓大、山本直司、谷田誠浩、大類　彩、斉藤　毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、平山重人、柳沢正史、長瀬　博
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学本郷キャンパス（東京都文京区）
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] オレキシン2受容体作動薬の設計・合成2016
- Author(s)
  長瀬　博、永原　崇志、斉藤　毅、沓村　憲樹、入鹿山　容子、小川　靖裕、黒田　大祐、合田　浩明、藤井　秀明、柳沢　正史
- Organizer
  第36回鎮痛薬・オピオイドペプチドシンポジウム
- Place of Presentation
  北海道大学（北海道札幌市）
- Year and Date
  2016-08-19
- Invited
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] YNT-707のOX1R拮抗作用発現のための必須構造の検討2016
- Author(s)
  関　知範、中嶋　龍、斉藤　毅、入鹿山容子、小川靖裕、石川有紀子、柳沢正史、長瀬　博
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学本郷キャンパス（東京都文京区）
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] オレキシン２受容体作動薬YNT-185の創製2016
- Author(s)
  斉藤　毅、永原崇志、沓村憲樹、中嶋　龍、細川直人、入鹿山容子、小川靖裕、富永　拡、黒田大介、合田浩明、藤井秀明、柳沢正史、長瀬　博
- Organizer
  第34回メディシナルケミストリーシンポジウム　サテライトセッション
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] モルヒナン骨格を有するオレキシン１受容体選択的拮抗薬の設計・合成とその薬理作用”2016
- Author(s)
  大類　彩、山本直司、谷田誠浩、岡田卓大、斉藤　毅、沓村憲樹、南雲康行、入鹿山容子、石川有紀子、小川靖裕、平山重人、柳沢正史、長瀬　博
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16H05098
[Presentation] 芳香族D-アミノ酸によるGPR109Bを介したヒト好中球細胞活性化機構について2009
- Author(s)
  入鹿山容子, 他
- Organizer
  第6回GPCR研究会
- Place of Presentation
  日本科学未来館
- Year and Date
  2009-05-08
- Data Source
  KAKENHI-PROJECT-18209008
[Presentation] 芳香族D-アミノ酸によるGPR109Bを介したヒト好中球細胞活性化機構について2009
- Author(s)
  入鹿山容子
- Organizer
  第6回GPCR研究会
- Place of Presentation
  日本科学未来館
- Year and Date
  2009-05-08
- Data Source
  KAKENHI-PROJECT-19390402

1. SAKURAI Takeshi (60251055)

# of Collaborated Projects: 7 results

# of Collaborated Products: 11 results
2. MURAKOSHI Nobuyuki (80447218)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 柳沢正史 (20202369)

# of Collaborated Projects: 2 results

# of Collaborated Products: 27 results
4. 斉藤毅 (80609933)

# of Collaborated Projects: 2 results

# of Collaborated Products: 24 results
5. MATSUZAKI Ichiyo (10229453)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TAKAHASHI Hiroshi (70236313)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MIYAUCHI Takashi (60222329)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MATSUDA Mitsuo (20110702)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Aonuma Kazutaka (10375488)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Fukusumi Shoji (10750002)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. Nagase Hiroshi (70383651)

# of Collaborated Projects: 1 results

# of Collaborated Products: 21 results
12. 田中あゆみ (00373085)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 浅川明弘 (10452947)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 藤原広臨 (10599608)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 尾内康臣 (40436978)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 征矢英昭 (50221346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 加藤隆弘 (70546465)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 佐久間英輔 (90295585)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 杉原玄一 (70402261)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 井上浩一 (80345818)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 鈴木高志 (90725938)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 乾明夫 (80168418)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 須藤信行 (60304812)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 榊美知子 (50748671)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 植木美乃 (40467478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 犬束歩 (30584776)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 杉山陽子 (00317512)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 牧之段学 (00510182)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 呉林なごみ (50133335)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 櫻井勝康 (70507920)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
31. 堀内大 (60992469)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. Ogawa Yasuhiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
33. 沓村憲樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
34. 神林崇

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 高橋智

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Irukayama Youko 入鹿山 容子

Irukayama Yoko 入鹿山 容子

IRUKAYAMA Yoko 入鹿山 容子

人鹿山 容子 イルカヤマ ヨウコ

IRUKAYAMA-TOMOBE Yoko 入鹿山 容子

Research Projects

Research Products

Co-Researchers

睡眠・覚醒リズム調整が全身性炎症による肺傷害を改善する効果と分子機構の解明Principal Investigator

Principal Investigator

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低酸素下での呼吸調節に関わる睡眠関連物質の役割

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Elucidation of molecular mechanism of cognitive dysfunction associated with sepsis and approach to new therapeutic agentsPrincipal Investigator

Principal Investigator

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Review Section

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Elucidation of metabolic rhythm regulation by orexin agonist

Principal Investigator

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Elucidation about roles of orexin receptor agonists on the immobility and lethargy in inflammatory model mice and approaches to new drug discoveryPrincipal Investigator

Principal Investigator

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Elucidation of molecular mechanism of orexin on the brain in endotoxin shockPrincipal Investigator

Principal Investigator

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Creation and Promotion of Willdynamics

Principal Investigator

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Elucidation of molecular mechanisms of spontaneous sudden cardiac death model mouse due to ventricular arrhythmia

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Development of novel orexin ligand and its pharmacological activity

Principal Investigator

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Effects of Neuropeptide W, and B on autonomic nervous systemPrincipal Investigator

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Roles of orexin-producing neurons in awakening from anesthesia : Analyses using various genetically-modified mice

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Roles of orexins in regulation of sleep/wake states

Principal Investigator

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Irukayama Youko 入鹿山容子

Irukayama Yoko 入鹿山容子

IRUKAYAMA Yoko 入鹿山容子

人鹿山容子イルカヤマヨウコ

IRUKAYAMA-TOMOBE Yoko 入鹿山容子

[Journal Article] Design　and　synthesis　of　novel　orexin　antagonists via structural simplification of the morphinan skeleton.2021