OTSUKA MOTOYUKI 大塚基之

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OTSUKA Motoyuki 大塚基之

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Researcher Number	90518945
Other IDs	https://orcid.org/0000-0003-2869-2881
Affiliation (Current)	2025: 岡山大学, 医歯薬学域, 教授 2025: 東京大学, 医学部附属病院, 病院診療医(出向)
Affiliation (based on the past Project Information) *help	2023 – 2025: 岡山大学, 医歯薬学域, 教授 2022 – 2023: 東京大学, 医学部附属病院, 届出研究員 2017 – 2021: 東京大学, 医学部附属病院, 講師 2009 – 2016: 東京大学, 医学部附属病院, 助教 2012 – 2014: 東京大学, 医学部附属病院消化器内科, 助教
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Basic Section 49010:Pathological biochemistry-related / Complex Systems Disease Theory / Gastroenterology Except Principal Investigator Gastroenterology / Basic Section 59040:Nutrition science and health science-related / Basic Section 49010:Pathological biochemistry-related / Basic Section 53010:Gastroenterology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor biology / Carcinogenesis
Keywords	Principal Investigator 膵癌 / microRNA / 膵がん / 反復配列RNA / 核酸 / 癌化 / 癌 / 非コードRNA / 分子腫瘍学 / マーカー … More / 血清マーカー / 環状RNA / 腸炎 / 慢性炎症 / 腸管上皮細胞 / トランスレーショナルリサーチ / 反復配列 / RNA / ヘテロクロマチン / 複雑系 / 内科 / 発癌 / non-coding RNA / 老化 / SASP / 細胞老化 / 加齢 / YB-1 / ＹＢ－１ / 非コードＲＮＡ / ミトコンドリア / レポーターマウス / PAIP2 / 炎症性発癌 / 炎症発癌 … More Except Principal Investigator microRNA / 肝癌 / 肝臓学 / 癌 / 核酸 / 免疫療法 / MICA / 膵癌 / 非コードRNA / 免疫学 / 肝細胞癌 / 癌幹細胞 / 生体イメージング / SRS / 恒常性破綻 / 遊離コレステロール / NASH / NAFLD / 細胞外小胞 / 肝細胞がん / MASLD / ミトコンドリア異常 / 抗腫瘍免疫応答 / 高分子ゲル / がんゲノム医療 / 癌遺伝子解析 / マイクロ流体デバイス / 細胞回収 / ゲル / シングルセル / 遺伝子解析 / 血中循環腫瘍細胞 / 分泌 / 切断酵素 / 腫瘍免疫 / ウィルス / おとり / Ｂ型肝炎 / ウイルス / decoy / HBV / 膵がん / スプライシング / 膵発癌 / NK細胞 / NKG2D / 自然免疫 / メタボローム / 肝臓がん / 脂肪肝 / 幹細胞 / 肝臓癌 / 染色体分裂異常 / エピジェネティクス / SOCS3 / インターフェロン / HCV / IFN / 国際情報交換アメリカ / DDX20 / 微生物 / 腸内細菌 / シグナル伝達 / 免疫 / microRNA122 / AFP / 肝細胞 / 分化 / 炎症 / 動物 Less

Mechanism of homeostasis failure of free cholesterol metabolism that is the starting point of steatohepatitis
- Principal Investigator
  
  渡辺彰吾
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Okayama University
MASLD関連肝細胞がんにおけるミトコンドリア異常の抗腫瘍免疫応答への影響の解明
- Principal Investigator
  
  上田優輝
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Okayama University
血中細胞外小胞因子を加えた機械学習による脂肪性肝疾患からの発癌高危険群の同定
- Principal Investigator
  
  佐藤雅哉
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  The University of Tokyo
膵癌における反復配列RNAの機能解析と治療選択最適化への応用Principal Investigator
- Principal Investigator
  
  大塚基之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Okayama University
  The University of Tokyo
Development of technologies using circulating tumor cells for genetic analysis of cancer
- Principal Investigator
  
  Ohnaga Takashi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Toyama Industrial Technology Research and Development Center
Identification of novel circular RNA in pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  Otsuka Motoyuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  The University of Tokyo
RNA機能変化を端緒とした炎症細胞社会学の確立Principal Investigator
- Principal Investigator
  
  大塚基之
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  The University of Tokyo
Enhancement of anti-tumor immunity by post-translational modification of MICA
- Principal Investigator
  
  Sato Masaya
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Impairment of microRNA function and carcinogenetic risk by agingPrincipal Investigator
- Principal Investigator
  
  OTSUKA MOTOYUKI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokyo
Oncogenetic process by the complexed system due to heterochromatin-derived RNAPrincipal Investigator
- Principal Investigator
  
  OTSUKA Motoyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Complex Systems Disease Theory
- Research Institution
  The University of Tokyo
Pathogenesis induced by interaction between microRNA and HBV transcripts
- Principal Investigator
  
  KONDO Yuuji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
microRNA expression during the multiple steps of pancreatic carcinogenesis
- Principal Investigator
  
  YAMAMOTO Natsuyo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
MICA expression regulation by small nucleic acids to prevent HCC occurrence
- Principal Investigator
  
  Sato Masaya
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Analysis of signaling pathways for liver cancer stem cell maintenance
- Principal Investigator
  
  MAEDA Shin
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Yokohama City University
Multi-step carcinogenesis due to non-coding repetitive RNA expressionPrincipal Investigator
- Principal Investigator
  
  Otsuka Motoyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokyo
Metabolomic analyses in microRNA-reduced HCC
- Principal Investigator
  
  KOndo Yuji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Elucidation of the enhanced IFN action by the non-coding RNA and its application on HCV treatment
- Principal Investigator
  
  YOSHIDA Haruhiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Elucidation of the biological function of non-coding repeat RNA in pancreatic cancer using mouse models
- Principal Investigator
  
  YAMAMOTO Natsuyo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Regulation of mucosal immunity and homeostasis by epithelial cells and dendritic cells
- Principal Investigator
  
  HIRATA YOSHIHIRO
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Analyses about the role of DDX20 in hepatocarcinogenesis
- Principal Investigator
  
  GOTO Tadashi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Roles of NF-kappaB activation in gastrointestinal tumorigenesis
- Principal Investigator
  
  MAEDA Shin
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Carcinogenesis
- Research Institution
  Yokohama City University
Chronic inflammation-induced mimRNA functional impairment may cause inflammation-associated tumorigenesis in gastroenterological organs.Principal Investigator
- Principal Investigator
  
  OTSUKA Motoyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokyo
Analyses of liver-specific miRNA function and the development of the strategy about the efficient induction of differentiation into hepatocytes
- Principal Investigator
  
  KONDO Yuuji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
iPS細胞からのヒト肝炎ウイルス複製マウスモデルの作製と応用Principal Investigator
- Principal Investigator
  
  大塚基之
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo

[Journal Article] Gut Bacteria-derived Membrane Vesicles Induce Colonic Dysplasia by Inducing DNA Damage in Colon Epithelial Cells2024
- Author(s)
  Miyakawa Yu、Otsuka Motoyuki、Shibata Chikako、Seimiya Takahiro、Yamamoto Keisuke、Ishibashi Rei、Kishikawa Takahiro、Tanaka Eri、Isagawa Takayuki、Takeda Norihiko、Kamio Noriaki、Imai Kenichi、Fujishiro Mitsuhiro
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: 17 Issue: 5 Pages: 745-767
- DOI
  10.1016/j.jcmgh.2024.01.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19517, KAKENHI-PROJECT-22K08110, KAKENHI-PROJECT-21K15916, KAKENHI-PROJECT-21H02893, KAKENHI-PROJECT-23K24090
[Journal Article] Satellite double-stranded RNA induces mesenchymal transition in pancreatic cancer by regulating alternative splicing2024
- Author(s)
  Iwata Takuma、Kishikawa Takahiro、Seimiya Takahiro、Notoya Genso、Suzuki Tatsunori、Shibata Chikako、Miyakawa Yu、Odawara Nariaki、Funato Kazuyoshi、Tanaka Eri、Yamagami Mari、Sekiba Kazuma、Otsuka Motoyuki、Koike Kazuhiko、Fujishiro Mitsuhiro
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 300 Issue: 3 Pages: 105742-105742
- DOI
  10.1016/j.jbc.2024.105742
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19517, KAKENHI-PROJECT-23K15033, KAKENHI-PROJECT-23K15065, KAKENHI-PROJECT-23K07392, KAKENHI-PROJECT-21K15368, KAKENHI-PROJECT-21H02893, KAKENHI-PROJECT-23K24090
[Journal Article] MicroRNA-451a inhibits gemcitabine-refractory biliary tract cancer progression by suppressing the MIF-mediated PI3K/AKT pathway2023
- Author(s)
  Obata Taisuke、Tsutsumi Koichiro、Ueta Eijiro、Oda Takashi、Kikuchi Tatsuya、Ako Soichiro、Fujii Yuki、Yamazaki Tatsuhiro、Uchida Daisuke、Matsumoto Kazuyuki、Horiguchi Shigeru、Kato Hironari、Okada Hiroyuki、Otsuka Motoyuki
- Journal Title
  
  Molecular Therapy - Nucleic Acids
  
  Volume: 34 Pages: 102054-102054
- DOI
  10.1016/j.omtn.2023.102054
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07962, KAKENHI-PROJECT-23K24090
[Journal Article] Combination of serum human satellite RNA and miR-21-5p levels as a biomarker for pancreatic cancer2023
- Author(s)
  Seimiya Takahiro、Suzuki Tatsunori、Iwata Takuma、Kishikawa Takahiro、Sekiba Kazuma、Shibata Chikako、Ishigaki Kazunaga、Fujiwara Hiroaki、Oyama Hiroki、Kanai Sachiko、Sato Tatsuya、Nakai Yousuke、Ishibashi Rei、Moriyama Masaru、Nakagawa Ryo、Ijichi Hideaki、Otsuka Motoyuki、Koike Kazuhiko
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 2 Pages: 106021-106021
- DOI
  10.1016/j.isci.2023.106021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19517, KAKENHI-PROJECT-22K15390, KAKENHI-PROJECT-21H02893, KAKENHI-PROJECT-20J20625, KAKENHI-PROJECT-22K15958, KAKENHI-PROJECT-21K15368, KAKENHI-PROJECT-21K15916, KAKENHI-PROJECT-23K24090
[Journal Article] Extracellular vesicle mediated RNA editing may underlie the heterogeneity and spread of hepatocellular carcinoma in human tissue and in vitro2023
- Author(s)
  Shibata Chikako、Otsuka Motoyuki、Shimizu Takayuki、Seimiya Takahiro、Kishikawa Takahiro、Aoki Taku、Fujishiro Mitsuhiro
- Journal Title
  
  Oncology Reports
  
  Volume: 50 Issue: 5 Pages: 194-194
- DOI
  10.3892/or.2023.8631
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19517, KAKENHI-PROJECT-23K07392, KAKENHI-PROJECT-21H02893, KAKENHI-PROJECT-23K24090
[Journal Article] Lipolysis by pancreatic cancer‐derived extracellular vesicles in cancer‐associated cachexia via specific integrins2022
- Author(s)
  Shibata Chikako、Otsuka Motoyuki、Seimiya Takahiro、Kishikawa Takahiro、Ishigaki Kazunaga、Fujishiro Mitsuhiro
- Journal Title
  
  Clinical and Translational Medicine
  
  Volume: 12 Issue: 11 Pages: 1089-1089
- DOI
  10.1002/ctm2.1089
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19517, KAKENHI-PROJECT-22K15390, KAKENHI-PROJECT-22K15958, KAKENHI-PROJECT-21H02893, KAKENHI-PROJECT-20J20625, KAKENHI-PROJECT-23K24090
[Journal Article] Smaller extracellular vesicles are released from pancreatic cancer cells by the alteration of the lipid composition under low glucose conditions2022
- Author(s)
  Shibata Chikako、Otsuka Motoyuki、Seimiya Takahiro、Ishigaki Kazunaga、Miyakawa Yu、Kishikawa Takahiro、Fujishiro Mitsuhiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 637 Pages: 314-321
- DOI
  10.1016/j.bbrc.2022.11.040
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19517, KAKENHI-PROJECT-22K15390, KAKENHI-PROJECT-22K15958, KAKENHI-PROJECT-21H02893, KAKENHI-PROJECT-20J20625, KAKENHI-PROJECT-23K24090
[Journal Article] Roles of circular RNAs in the pathogenesis and treatment of pancreatic cancer2022
- Author(s)
  Seimiya Takahiro、Otsuka Motoyuki、Fujishiro Mitsuhiro
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 10
- DOI
  10.3389/fcell.2022.1023332
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24090
[Journal Article] HBx-induced degradation of Smc5/6 complex impairs homologous recombination-mediated repair of damaged DNA.2022
- Author(s)
  Sekiba K, Otsuka M, Funato K, Miyakawa Y, Tanaka E, Seimiya T, Yamagami M, Tsutsumi T, Okushin K, Miyakawa K, Ryo A, Koike K.
- Journal Title
  
  J Hepatol.
  
  Volume: 76 Issue: 1 Pages: 53-62
- DOI
  10.1016/j.jhep.2021.08.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03430, KAKENHI-PROJECT-20K17014
[Journal Article] Mutant KRAS drives metabolic reprogramming and autophagic flux in premalignant pancreatic cells.2021
- Author(s)
  Suzuki T, Kishikawa T, Sato T, Takeda N, Sugiura Y, Seimiya T, Sekiba K, Ohno M, Iwata T, Ishibashi R, Otsuka M, Koike K.
- Journal Title
  
  Cancer Gene Ther.
  
  Volume: - Issue: 5 Pages: 505-518
- DOI
  10.1038/s41417-021-00326-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03430, KAKENHI-PROJECT-21K15368, KAKENHI-PROJECT-21K15916, KAKENHI-PROJECT-21H02893
[Journal Article] Humanized virus-suppressing factor inhibits hepatitis B virus infection by targeting viral cell entry2021
- Author(s)
  Miyakawa Y, Otsuka M, Sekiba K, Funato K, Koike K.
- Journal Title
  
  Heliyon .
  
  Volume: 14 Issue: 7 Pages: e07586-e07586
- DOI
  10.1016/j.heliyon.2021.e07586
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03430
[Journal Article] Potential of HBx Gene for Hepatocarcinogenesis in Noncirrhotic Liver.2021
- Author(s)
  Sekiba K, Otsuka M, Koike K
- Journal Title
  
  Semin Liver Dis.
  
  Volume: 42 Issue: 02 Pages: 142-149
- DOI
  10.1055/s-0041-1723033
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03430
[Journal Article] Aberrant expression of a novel circular RNA in pancreatic cancer2020
- Author(s)
  Seimiya Takahiro、Otsuka Motoyuki、Iwata Takuma、Tanaka Eri、Sekiba Kazuma、Shibata Chikako、Moriyama Masaru、Nakagawa Ryo、Maruyama Reo、Koike Kazuhiko
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 66 Issue: 2 Pages: 181-191
- DOI
  10.1038/s10038-020-00826-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03430, KAKENHI-PROJECT-20J11303, KAKENHI-PROJECT-20J20625
[Journal Article] Emerging Roles of Exosomal Circular RNAs in Cancer2020
- Author(s)
  Seimiya Takahiro、Otsuka Motoyuki、Iwata Takuma、Shibata Chikako、Tanaka Eri、Suzuki Tatsunori、Koike Kazuhiko
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 8 Pages: 568366-568366
- DOI
  10.3389/fcell.2020.568366
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03430
[Journal Article] HBx increases EGFR expression by inhibiting miR129?5p function2020
- Author(s)
  Ochi Masanori、Otsuka Motoyuki、Maruyama Reo、Koike Kazuhiko
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 529 Issue: 2 Pages: 198-203
- DOI
  10.1016/j.bbrc.2020.06.018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03430
[Journal Article] Inhibition of HBV Transcription From cccDNA With Nitazoxanide by Targeting the HBx?DDB1 Interaction2019
- Author(s)
  Sekiba Kazuma、Otsuka Motoyuki、Ohno Motoko、Yamagami Mari、Kishikawa Takahiro、Suzuki Tatsunori、Ishibashi Rei、Seimiya Takahiro、Tanaka Eri、Koike Kazuhiko
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: 7 Issue: 2 Pages: 297-312
- DOI
  10.1016/j.jcmgh.2018.10.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09405, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05024, KAKENHI-PROJECT-16H05149, KAKENHI-PROJECT-16KT0109, KAKENHI-PROJECT-16K09344, KAKENHI-PROJECT-17K15923, KAKENHI-PROJECT-19H03430
[Journal Article] Identifying Inhibitors of the HBx-DDB1 Interaction Using a Split Luciferase Assay System2019
- Author(s)
  Sekiba Kazuma、Otsuka Motoyuki、Koike Kazuhiko
- Journal Title
  
  Journal of Visualized Experiments
  
  Volume: 154 Issue: 154
- DOI
  10.3791/60652
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03430, KAKENHI-PROJECT-19J11829
[Journal Article] Pevonedistat, a Neuronal Precursor Cell-Expressed Developmentally Down-Regulated Protein 8-Activating Enzyme Inhibitor, Is a Potent Inhibitor of Hepatitis B Virus2019
- Author(s)
  Sekiba Kazuma、Otsuka Motoyuki、Ohno Motoko、Yamagami Mari、Kishikawa Takahiro、Seimiya Takahiro、Suzuki Tatsunori、Tanaka Eri、Ishibashi Rei、Funato Kazuyoshi、Koike Kazuhiko
- Journal Title
  
  Hepatology
  
  Volume: in press Issue: 5 Pages: 1903-1915
- DOI
  10.1002/hep.30491
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-18H05024, KAKENHI-PROJECT-16H05149, KAKENHI-PROJECT-17K15923, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-19H03430
[Journal Article] Detection of circulating colorectal cancer cells by a custom microfluid system before and after endoscopic metallic stent placement2019
- Author(s)
  REI ISHIBASHI, SHUNTARO YOSHIDA, NARIAKI ODAWARA, TAKAHIRO KISHIKAWA, RYO KONDO, AYAKO NAKADA, RYUNOSUKE HAKUTA, NAMINATSU TAKAHARA, ERI TANAKA, KAZUMA SEKIBA, TAKAHIRO SEIMIYA, TAKASHI OHNAGA, MOTOYUKI OTSUKA and KAZUHIKO KOIKE
- Journal Title
  
  ONCOLOGY LETTERS
  
  Volume: 18 Pages: 6397-6404
- DOI
  10.3892/ol.2019.11047
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07746, KAKENHI-PROJECT-19K23881, KAKENHI-PUBLICLY-18H05024, KAKENHI-PROJECT-19H03430, KAKENHI-PROJECT-16K08974
[Journal Article] Expression of circular RNA CDR1?AS in colon cancer cells increases cell surface PD?L1 protein levels2019
- Author(s)
  Tanaka Eri、Miyakawa Yu、Kishikawa Takahiro、Seimiya Takahiro、Iwata Takuma、Funato Kazuyoshi、Odawara Nariaki、Sekiba Kazuma、Yamagami Mari、Suzuki Tatsunori、Ishibashi Rei、Otsuka Motoyuki、Koike Kazuhiko
- Journal Title
  
  Oncology Reports
  
  Volume: 42 Pages: 1459-1466
- DOI
  10.3892/or.2019.7244
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K23881, KAKENHI-PUBLICLY-18H05024, KAKENHI-PROJECT-19H03430
[Journal Article] Inflammation and de-differentiation in pancreatic carcinogenesis2018
- Author(s)
  Seimiya Takahiro、Otsuka Motoyuki、Iwata Takuma、Tanaka Eri、Suzuki Tatsunori、Sekiba Kazuma、Yamagami Mari、Ishibashi Rei、Koike Kazuhiko
- Journal Title
  
  World Journal of Clinical Cases
  
  Volume: 6 Issue: 15 Pages: 882-891
- DOI
  10.12998/wjcc.v6.i15.882
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09405, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-16K09344
[Journal Article] ISGF3 with reduced phosphorylation is associated with constitutive expression of interferon-induced genes in aging cells2018
- Author(s)
  Yamagami Mari、Otsuka Motoyuki、Kishikawa Takahiro、Sekiba Kazuma、Seimiya Takahiro、Tanaka Eri、Suzuki Tatsunori、Ishibashi Rei、Ohno Motoko、Koike Kazuhiko
- Journal Title
  
  npj Aging and Mechanisms of Disease
  
  Volume: 4 Issue: 1 Pages: 11-11
- DOI
  10.1038/s41514-018-0030-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09405, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-16H05149, KAKENHI-PROJECT-16KT0109, KAKENHI-PROJECT-17K15923
[Journal Article] Satellite RNA Increases DNA Damage and Accelerates Tumor Formation in Mouse Models of Pancreatic Cancer2018
- Author(s)
  Kishikawa Takahiro、Otsuka Motoyuki、Suzuki Tatsunori、Seimiya Takahiro、Sekiba Kazuma、Ishibashi Rei、Tanaka Eri、Ohno Motoko、Yamagami Mari、Koike Kazuhiko
- Journal Title
  
  Molecular Cancer Research
  
  Volume: 16 Issue: 8 Pages: 1255-1262
- DOI
  10.1158/1541-7786.mcr-18-0139
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-16KT0109, KAKENHI-PROJECT-16K09344, KAKENHI-PROJECT-17K15923
[Journal Article] Hepatitis B virus pathogenesis: Fresh insights into hepatitis B virus RNA2018
- Author(s)
  Sekiba Kazuma、Otsuka Motoyuki、Ohno Motoko、Yamagami Mari、Kishikawa Takahiro、Suzuki Tatsunori、Ishibashi Rei、Seimiya Takahiro、Tanaka Eri、Koike Kazuhiko
- Journal Title
  
  World Journal of Gastroenterology
  
  Volume: 24 Issue: 21 Pages: 2261-2268
- DOI
  10.3748/wjg.v24.i21.2261
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-16K09344
[Journal Article] DHX9 regulates production of hepatitis B virus-derived circular RNA and viral protein levels2018
- Author(s)
  Sekiba Kazuma、Otsuka Motoyuki、Ohno Motoko、Kishikawa Takahiro、Yamagami Mari、Suzuki Tatsunori、Ishibashi Rei、Seimiya Takahiro、Tanaka Eri、Koike Kazuhiko
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 30 Pages: 20953-20964
- DOI
  10.18632/oncotarget.25104
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-16KT0109, KAKENHI-PROJECT-17K15923
[Journal Article] RASAL1 is a potent regulator of hepatic stellate cell activity and liver fibrosis2017
- Author(s)
  Takata Akemi、Otsuka Motoyuki、Kishikawa Takahiro、Yamagami Mari、Ishibashi Rei、Sekiba Kazuma、Suzuki Tatsunori、Ohno Motoko、Yamashita Yui、Abe Takaya、Masuzaki Ryota、Ikenoue Tsuneo、Koike Kazuhiko
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 39 Pages: 64840-64852
- DOI
  10.18632/oncotarget.17609
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16KT0109, KAKENHI-PROJECT-16K09344, KAKENHI-PROJECT-17K15923, KAKENHI-PROJECT-15H04807, KAKENHI-PROJECT-16H05149
[Journal Article] Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands.2017
- Author(s)
  Nakagawa H, Suzuki N, Hirata Y, Hikiba Y, Hayakawa Y, Kinoshita H, Ihara S, Uchino K, Nishikawa Y, Ijichi H, Otsuka M, Arita J, Sakamoto Y, Hasegawa K, Kokudo N, Tateishi K, Koike K.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 114(19) Issue: 19
- DOI
  10.1073/pnas.1619416114
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15107, KAKENHI-PROJECT-15H04807, KAKENHI-PROJECT-15K09038, KAKENHI-PROJECT-15K09039
[Journal Article] Transcriptional activation of the MICA gene with an engineered CRISPR-Cas9 system2017
- Author(s)
  Sekiba K, Yamagami M, Otsuka M, Suzuki T, Kishikawa T, Ishibashi R, Ohno M, Sato M, Koike K
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: - Issue: 2 Pages: 521-525
- DOI
  10.1016/j.bbrc.2017.03.076
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04807, KAKENHI-PROJECT-26460984, KAKENHI-PROJECT-16KT0109, KAKENHI-PROJECT-17K09405, KAKENHI-PROJECT-17K15923, KAKENHI-PROJECT-16H05149
[Journal Article] MicroRNAs and liver disease2017
- Author(s)
  Otsuka M, Kishikawa T, Yoshikawa T, Yamagami M, Ohno M, Takata A, Shibata C, Ishibashi R, Koike K.
- Journal Title
  
  J Hum Genet.
  
  Volume: 62 Issue: 1 Pages: 75-80
- DOI
  10.1038/jhg.2016.53
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K09344
[Journal Article] Repression of miRNA function mediates inflammation-associated colon tumorigenesis.2017
- Author(s)
  Yoshikawa T., J. F. Wu, M. Otsuka, T. Kishikawa, N. Suzuki, A. Takata, M. Ohno, R. Ishibashi, M. Yamagami, R. Nakagawa, N. Kato, M. Miyazawa, J. Han, and K. Koike
- Journal Title
  
  Gastroenterology
  
  Volume: 152 Issue: 3 Pages: 631-643
- DOI
  10.1053/j.gastro.2016.10.043
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01268, KAKENHI-PROJECT-16H05199, KAKENHI-PROJECT-26860492, KAKENHI-PROJECT-16K19329, KAKENHI-PROJECT-16KT0109, KAKENHI-PROJECT-16K09344, KAKENHI-PROJECT-16H05149, KAKENHI-PROJECT-15K09038
[Journal Article] Satellite RNAs promote pancreatic oncogenic process via the dysfunction of YBX1.2016
- Author(s)
  Kishikawa T, Otsuka M, Yoshikawa T, Ohno M, Ijichi H, and Koike K
- Journal Title
  
  Nature Communications
  
  Volume: 7 Issue: 1 Pages: 13006-13006
- DOI
  10.1038/ncomms13006
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26860492, KAKENHI-PROJECT-16KT0109
[Journal Article] Mutual antagonism between hepatitis B viral mRNA and host microRNA let-7.2016
- Author(s)
  Takata A, Otsuka M, Ohno M, Kishikawa T, Yoshikawa T, Koike K.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 23237-23237
- DOI
  10.1038/srep23237
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293076, KAKENHI-PROJECT-15H04807, KAKENHI-PROJECT-26860492
[Journal Article] Quantitation of circulating satellite RNAs in pancreatic cancer patients.2016
- Author(s)
  4.Kishikawa T, #Otsuka M, Yoshikawa T, Ohno M, Yamamoto K, Yamamoto N, Kotani A, Koike K.
- Journal Title
  
  JCI Insight
  
  Volume: 1
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16KT0109
[Journal Article] Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine.2015
- Author(s)
  Kishikawa T, Otsuka M, Tan PS, Ohno M, Sun X, Yoshikawa T, Shibata C, Takata A, Kojima K, Takehana K, Ohishi M, Ota S, Noyama T, Kondo Y, Sato M, Soga T, Hoshida Y, Koike K.
- Journal Title
  
  Oncotarget.
  
  Volume: 6 Pages: 8339-52
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460979
[Journal Article] Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine2015
- Author(s)
  Kishikawa T, Otsuka M, Tan PS, Ohno M, Sun X, Yoshikawa T, Shibata C, Takata A, Kojima K, Takehana K, Ohishi M, Ota S, Noyama T, Kondo Y, Sato M, Soga T, Hoshida Y, Koike K.
- Journal Title
  
  Oncotarget.
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590956
[Journal Article] Diagnostic and therapeutic application of noncoding RNAs for hepatocellular carcinoma.2015
- Author(s)
  Shibata C, Otsuka M, Kishikawa T, Ohno M, Yoshikawa T, Takata A, Koike K.
- Journal Title
  
  World J Hepatol.
  
  Volume: 7 Pages: 1-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590956
[Journal Article] Circulating RNAs as new biomarkers for detecting pancreatic cancer.2015
- Author(s)
  Kishikawa T, Otsuka M, Ohno M, Yoshikawa T, Takata A, Koike K.
- Journal Title
  
  World J Gastroenterol.
  
  Volume: 21 Issue: 23 Pages: 8527-8540
- DOI
  10.3748/wjg.v21.i23.7084
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293076
[Journal Article] Tissue-specific regulation of p38α-mediated inflammation in ConA-induced acute liver damage.2015
- Author(s)
  Bang BR, Shim EJ, Otsuka M, Otsu K, Kang YJ.
- Journal Title
  
  J Immunol.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293076
[Journal Article] Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine.2015
- Author(s)
  Kishikawa T, Otsuka M, Tan PS, Ohno M, Sun X, Yoshikawa T, Shibata C, Takata A, Kojima K, Takehana K, Ohishi M, Ota S, Noyama T, Kondo Y, Sato M, Soga T, Hoshida Y, Koike K.
- Journal Title
  
  Oncotarget.
  
  Volume: 6 Pages: 8339-8352
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293076
[Journal Article] Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine.2015
- Author(s)
  2.Kishikawa T, #Otsuka M, Poh Seng T, Ohno M, Sun X, Yoshikawa T, Shibata C, Takata A, Kojima K, TakehanaK, Ohishi M, Ota S, Noyama T, Kondo Y, Sato M, Soga T, Hoshida Y, Koike K.
- Journal Title
  
  Oncotarget
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293076
[Journal Article] Development of a　screening method to identify regulators of MICA shedding.2015
- Author(s)
  Kishikawa T, Otsuka M, Ohno M, Yoshikawa T, Sato M, Koike K.
- Journal Title
  
  Biochem Biophys Res　Commun.
  
  Volume: 465 Issue: 4 Pages: 764-768
- DOI
  10.1016/j.bbrc.2015.08.081
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460984, KAKENHI-PROJECT-26860492, KAKENHI-PROJECT-25293076
[Journal Article] Diagnostic and therapeutic application of noncoding RNAs for hepatocellular carcinoma.2015
- Author(s)
  Shibata C, Otsuka M, Kishikawa T, Ohno M, Yoshikawa T, Takata A, Koike K.
- Journal Title
  
  World J Hepatol.
  
  Volume: 27 Issue: 1 Pages: 1-6
- DOI
  10.4254/wjh.v7.i1.1
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293076, KAKENHI-PROJECT-25460979, KAKENHI-PROJECT-26860492
[Journal Article] ecreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine.2015
- Author(s)
  Kishikawa T, Otsuka M, Tan PS, Ohno M, Sun X, Yoshikawa T, Shibata C, Takata A, Kojima K, Takehana K, Ohishi M, Ota S, Noyama T, Kondo Y, Sato M, Soga T, Hoshida Y, Koike K.
- Journal Title
  
  Oncotarget
  
  Volume: 6 Pages: 8339-8352
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460984
[Journal Article] ROCK inhibition enhances microRNA function by promoting deadenylation of targeted mRNAs via increasing PAIP2 expression2015
- Author(s)
  Yoshikawa, T. Wu, J. Otsuka, M. Kishikawa, T. Ohno, M. Shibata, C. Takata, A. Han, F. Kang, Y. J. Chen, C. A. Shyu, A. B. Han, J. Koike, K
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 43(15) Issue: 15 Pages: 7577-89
- DOI
  10.1093/nar/gkv728
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860492, KAKENHI-PROJECT-15H04807, KAKENHI-PROJECT-25860520, KAKENHI-PROJECT-25293076
[Journal Article] The flavonoid apigenin inhibits hepatitis C virus replication by decreasing mature microRNA122 levels.2014
- Author(s)
  Shibata C, Ohno M, Otsuka M, Kishikawa T, Goto K, Muroyama R, Kato N, Yoshikawa T, Takata A, Koike K.
- Journal Title
  
  Virology
  
  Volume: 462-463 Pages: 42-48
- DOI
  10.1016/j.virol.2014.05.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390184, KAKENHI-PROJECT-24590956, KAKENHI-PROJECT-25293076, KAKENHI-PROJECT-25460979
[Journal Article] Specific delivery of microRNA93 into HBV-replicating hepatocytes downregulates protein expression of liver cancer susceptible gene MICA.2014
- Author(s)
  Ohno M, Otsuka M, Kishikawa T, Shibata C, Yoshikawa T, Takata A, Muroyama R, Kowatari N, Sato M, Kato N, Kuroda S, Koike K
- Journal Title
  
  Oncotarget
  
  Volume: 5 Pages: 5581-90
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460984
[Journal Article] The role of microRNAs in hepatocarcinogenesis: current knowledge and future prospects.2014
- Author(s)
  Otsuka M, Kishikawa T, Yoshikawa T, Ohno M, Takata A, Shibata C, Koike K.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 49 Issue: 2 Pages: 173-84
- DOI
  10.1007/s00535-013-0909-8
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293076, KAKENHI-PROJECT-25860520, KAKENHI-PROJECT-26460984, KAKENHI-PROJECT-26860492
[Journal Article] Histone demethylase KDM4C regulates sphere formation by mediating the crosstalk between Wnt and Notch pathways in colonic cancer cells2013
- Author(s)
  Otsuka M
- Journal Title
  
  Carcinogenesis
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390058
[Journal Article] IL28Bminor allele is associated with a younger age of onset of hepatocellular carcinoma in patients with chronic hepatitis C virus infection2013
- Author(s)
  Otsuka M
- Journal Title
  
  J Gastroenterol
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390058
[Journal Article] A genome-wide association study of HCV-induced liver cirrhosis in the Japanese populationidentifies novel susceptibility loci at the MHC region2013
- Author(s)
  Otsuka M
- Journal Title
  
  J Hepatol
  
  Volume: I(n press) Issue: 5 Pages: 875-882
- DOI
  10.1016/j.jhep.2012.12.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390058, KAKENHI-PROJECT-23710316, KAKENHI-PROJECT-24390184
[Journal Article] Unique haploinsufficient role of the microRNA-processing molecule Dicer1 in a murine colitis-associated tumorigenesis model.2013
- Author(s)
  Yoshikawa T, Otsuka M, Kishikawa T, Takata A, Ohno M, Shibata C, Kang YJ, Yoshida H, Koike K.
- Journal Title
  
  PLoS One.
  
  Volume: 8(9) Issue: 9 Pages: e71969-e71969
- DOI
  10.1371/journal.pone.0071969
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590956, KAKENHI-PROJECT-25293076, KAKENHI-PROJECT-25860520
[Journal Article] Regulation of the expression of the liver cancer susceptibility gene MICA by microRNAs.2013
- Author(s)
  Kishikawa T, Otsuka M, Yoshikawa T, Ohno M, Takata A, Shibata C, Kondo Y, Akanuma M, Yoshida H, Koike K.
- Journal Title
  
  Sci Rep.
  
  Volume: 3 Issue: 1 Pages: 2739-2739
- DOI
  10.1038/srep02739
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590956, KAKENHI-PROJECT-25293076, KAKENHI-PROJECT-25460979
[Journal Article] The flavonoid apigenin improves glucose tolerance through inhibition of microRNA maturation in miRNA103 transgenic mice.2013
- Author(s)
  Ohno M, Shibata C, Kishikawa T, Yoshikawa T, Takata A, Kojima K, Akanuma M, Kang YJ, Yoshida H, Otsuka M, Koike K.
- Journal Title
  
  Sci Rep.
  
  Volume: 3 Issue: 1 Pages: 2553-2553
- DOI
  10.1038/srep02553
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293076
[Journal Article] Inhibition of microRNA122 decreases SREBP1 expression by modulating suppressor of cytokine signaling 3 expression.2013
- Author(s)
  Shibata C, Kishikawa T, Otsuka M, Ohno M, Yoshikawa T, Takata A, Yoshida H, Koike K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 438(1) Issue: 1 Pages: 230-5
- DOI
  10.1016/j.bbrc.2013.07.064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590956, KAKENHI-PROJECT-25293076
[Journal Article] A miRNA machinery component DDX20 controls NF-□B via microRNA-140 function2012
- Author(s)
  Otsuka M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 420(3) Pages: 564-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390058
[Journal Article] MicroRNA-140 acts as a liver tumor suppressor by controlling NF-κB activity by directly targeting DNA methyltransferase 1 (Dnmt1) expression2012
- Author(s)
  Otsuka M
- Journal Title
  
  Hepatology
  
  Volume: 57 Issue: 1 Pages: 162
- DOI
  10.1002/hep.26011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390058, KAKENHI-PROJECT-23590960, KAKENHI-PROJECT-24590956
[Journal Article] Silencing of microRNA-122 enhances interferon- α signaling in the liver through regulating SOCS3 promoter methylation2012
- Author(s)
  Otsuka M
- Journal Title
  
  Sci Rep
  
  Volume: 2 Issue: 1 Pages: 637-637
- DOI
  10.1038/srep00637
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390058, KAKENHI-PROJECT-24590956
[Journal Article] A miRNA machinery component DDX20 controls NF-κB via microRNA-140 function.2012
- Author(s)
  Otsuka M et al. (8人中2番目)
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 420 Issue: 3 Pages: 564-9
- DOI
  10.1016/j.bbrc.2012.03.034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390058, KAKENHI-PROJECT-23590960
[Journal Article] MicroRNA122 is a key regulator of alpha-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma2011
- Author(s)
  Kojima K, Takata A, Vadnais C, Otsuka M, Yoshikawa T, Akanuma M, Kondo Y, Kang YJ, Kishikawa T, Kato N, Xie Z, Zhang WJ, Yoshida H, Omata M, Nepveu A, Koike K
- Journal Title
  
  Nat Commun.
  
  Volume: 2 Issue: 1 Pages: 338-338
- DOI
  10.1038/ncomms1345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390058, KAKENHI-PROJECT-22590718
[Journal Article] Altered Composition of Fatty Acids Exacerbates Hepatotumorigenesis duringActivation of the Phosphatidylinositol 3-kinase Pathway2011
- Author(s)
  Kudo Y, Tanaka Y, Tateishi K, Yamamoto K, Yamamoto S, Mohri D, IsomuraY,Seto M, Nakagawa H, Asaoka Y, Tada M, Ohta M, Ijichi H, Hirata Y, Otsuka M,Ikenoue T, Maeda S, Shiina S, Yoshida H, Nakajima O, Kanai F, Omata M, Koike K
- Journal Title
  
  J Hepatol. J Hepatol
  
  Volume: 55 Pages: 1400-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300317
[Journal Article] MicroRNA122 is a key regulator of alpha-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma2011
- Author(s)
  Kojima K, Takata A, Vadnais C, Otsuka M, Yoshikawa T, Akanuma M, Kondo Y, Kang YJ, Kishikawa T, Kato N, Xie Z, Zhang WJ, Yoshida H,Omata M, Nepveu A, Koike K
- Journal Title
  
  Nat Commun
  
  Volume: 2 Pages: 338-338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390058
[Journal Article] Reducedexpression of RAS protein activator like-1 in gastric cancer2011
- Author(s)
  Seto M, Ohta M, Ikenoue T, Sugimoto T, Asaoka Y, Tada M, Mohri D, Kudo Y,Ijichi H, Tateishi K, Otsuka M, Hirata Y, Maeda S, Koike K, Omata M
- Journal Title
  
  Int J Cancer
  
  Volume: 128 Pages: 1293-302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300317
[Journal Article] Serum Metabolomics Reveals g-Gutamyl dipeptides as Biomarkers for Discrimination among Different Forms of Liver Disease.2011
- Author(s)
  Soga T, Suglmoto M, Monma M, Mari M, lgarashi K, Kashikura K, Ikeda S, Hirayama A, Yamsmoto T, Yoshida H, Otsuka M, Tsuji S, Yatomi Y, Sakuragawa T, Watanabe H, Nihei K, Saito T, Kawata S, Suzuki H, Tomita M, Suematsu M.
- Journal Title
  
  J Hepatol.
  
  Volume: (In press)(掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390058
[Journal Article] Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma2011
- Author(s)
  Kumar V, Kato N, Urabe Y, Takahashi A, Muroyama R, Hosono N, Otsuka M, Tateishi R, Omata M, Nakagawa H, Koike K, Kamatani N, Kubo M, Nakamura Y, Matsuda K
- Journal Title
  
  Nat Genet
  
  Volume: 43 Pages: 455-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390058
[Journal Article] Direct differentiation of hepatic cells from human induced plunpotent stem cells sing a limited number of cytokines.2011
- Author(s)
  Takata A, Otsuka M, Kogiso T, Kojima K, Yoshikawa T, Tateishi R, Kato N, Shiina S, Yoshida H, Omata M, Koike K.
- Journal Title
  
  Hepatol Int.
  
  Volume: (In press)(掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390058
[Journal Article] MicroRNA122 is a key regulator of alpha-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma.2011
- Author(s)
  Kojima K, Takata A, Vadnais C, Otsuka M, Yoshikawa T, Akanuma M, Kondo Y, Kang YJ, Kishikawa T, Kato N, Xie Z, Zhang WJ, Yoshida H,Omata M, Nepveu A, Koike K.
- Journal Title
  
  Nat Commun
  
  Volume: 2 Pages: 338-338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590718
[Journal Article] Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma2011
- Author(s)
  Kumar V, Kato N, Urabe Y, Takahashi A, Muroyama R, Hosono N, Otsuka M, Tateishi R, Omata M, Nakagawa H, Koike K, Kamatani N, Kubo M, Nakamura Y, Matsuda K
- Journal Title
  
  Nat Genet.
  
  Volume: 43 Issue: 5 Pages: 455-8
- DOI
  10.1038/ng.809
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390058, KAKENHI-PROJECT-23651192, KAKENHI-PROJECT-221S0001
[Journal Article] Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.2011
- Author(s)
  Kumar V, Kato N, Urabe Y, Takahashi A, Muroyama R, Hosono N, Otsuka M, Tateishi R, Omata M, Nakagawa H, Koike K, Kamatani N, Kubo M, Nakamura Y. Matsuda K.
- Journal Title
  
  Nat Genet.
  
  Volume: (In press)(掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390058
[Journal Article] Altered composition of fatty acids exacerbates hepatotumorigenesis during activation ofthe phosphatidylinositol 3-kinase pathway2011
- Author(s)
  Kudo Y, Tanaka Y, Tateishi K, Yamamoto K, Yamamoto S, Mohri D, Isomura Y, SetoM, Nakagawa H, Asaoka Y, Tada M, Ohta M, Ijichi H, Hirata Y, Otsuka M, Ikenoue T, Maeda S, Shiina S, Yoshida H, Nakajima O, Kanai F, Omata M, Koike K
- Journal Title
  
  J Hepatol
  
  Volume: 55 Pages: 1400-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300317
[Journal Article] MicroRNA-22 and microRNA-140 suppress NF-κB activity by regulating the expression of NF-κB coactivators2011
- Author(s)
  Takata A, Otsuka M, Kojima K, Yoshikawa T, Kishikawa T, Yoshida H, Koike K
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 411(4) Issue: 4 Pages: 826-31
- DOI
  10.1016/j.bbrc.2011.07.048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590960
[Journal Article] Receptor for activated protein kinase C : Requirement for efficient microRNA function and reduced expression in hepatocellular carcinoma2011
- Author(s)
  Motoyuki, Otsuka
- Journal Title
  
  PLoS ONE
  
  Volume: 6 Issue: 9 Pages: e24359-e24359
- DOI
  10.1371/journal.pone.0024359
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390090, KAKENHI-PLANNED-22117003, KAKENHI-PROJECT-22390058
[Journal Article] Transdifferentiation of human fibroblasts into hepatocyte-like cells by defined transcriptional factors
- Author(s)
  Otsuka M
- Journal Title
  
  Hepatol Int
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390058
[Patent] Abberant expression of novel circular RNA in pancreatic cancer2020
- Inventor(s)
  Seimiya T, Otsuka M, Koiek K.
- Industrial Property Rights Holder
  Seimiya T, Otsuka M, Koiek K.
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-19H03430
[Presentation] 抗原抗体反応を利用したマイクロ流体デバイスによる多様な癌細胞の単離・回収とゲノム解析2022
- Author(s)
  大永崇、石橋嶺、大塚基之、嶋田裕
- Organizer
  第40 回日本ヒト細胞学会
- Data Source
  KAKENHI-PROJECT-19K07746
[Presentation] 膵癌で高発現する新規環状 RNA の同定とバイオマーカー応用2021
- Author(s)
  清宮崇博、大塚基之、小池和彦
- Organizer
  第107回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-19H03430
[Presentation] miRNA and Liver Disease2016
- Author(s)
  Motoyuki Otsuka
- Organizer
  25th conference of the Asian Pacific Association for the Study of Liver (APASL)
- Place of Presentation
  品川プリンスホテル（東京都・品川区）
- Year and Date
  2016-02-19
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293076
[Presentation] 慢性炎症が惹起するmicroRNA機能不全に伴う肝発癌機構の解明2015
- Author(s)
  大塚基之
- Organizer
  日本抗加齢医学会総会
- Place of Presentation
  福岡国際会議場（福岡県・福岡市）
- Year and Date
  2015-05-29
- Invited
- Data Source
  KAKENHI-PROJECT-25293076
[Presentation] The biological Significance of the decreased expression levels of miR122 in liver cancer2014
- Author(s)
  Motoyuki Otsuka
- Organizer
  JSTさきがけ国際シンポジウム
- Place of Presentation
  Tokyo
- Invited
- Data Source
  KAKENHI-PROJECT-25293076
[Presentation] Functional impairment of microRNAs induced by chronic inflammation is a cause of inflammationassociated colon tumorigenesis in mice2013
- Author(s)
  Otsuka M
- Organizer
  The 2nd JSG International Topic Conference
- Place of Presentation
  Kagoshima
- Year and Date
  2013-03-22
- Data Source
  KAKENHI-PROJECT-22390058
[Presentation] Functional impairment ofmicroRNAs induced by chronic inflammation is the cause of inflammationassociated colon tumorigenesis2013
- Author(s)
  Otsuka M
- Organizer
  JST-CREST international symposium Frontiers inImmunology & Inflammation
- Place of Presentation
  Tokyo
- Year and Date
  2013-02-12
- Data Source
  KAKENHI-PROJECT-22390058
[Presentation] MicroRNA involvement inHepatocellular Carcinoma2011
- Author(s)
  Otsuka M
- Organizer
  日本癌学会International Symposium
- Place of Presentation
  Nagoya
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-22390058
[Presentation] 持続炎症に伴うmicroRNA機能異常が原因となる消化器癌の病態解明2011
- Author(s)
  吉川剛史、大塚基之、小池和彦
- Organizer
  第19回日本消化器関連学会週間
- Place of Presentation
  福岡マリンメッセ(福岡)
- Year and Date
  2011-10-21
- Data Source
  KAKENHI-PROJECT-22390058
[Presentation] microRNA maychinery構成因子DDX20の発現低下に伴う microRNA機能の減弱によって惹起される肝発癌経路の同定2010
- Author(s)
  大塚基之、高田朱弥、小島健太郎、前田愼、立石敬介、池上恒雄、平田善裕、建石良介、椎名秀一朗、吉田晴彦、小池和彦
- Organizer
  臨床分子医学会
- Place of Presentation
  東京国際フォーラム(東京都)
- Year and Date
  2010-04-10
- Data Source
  KAKENHI-PROJECT-22390058
[Presentation] microRNA machinery構成因子DDX20の発現低下に伴うmicroRNA機能の減弱によって惹起される肝発癌経路の同定2010
- Author(s)
  大塚基之、高田朱弥、小島健太郎、前田愼、立石敬介、池上恒雄、平田善裕、建石良介、椎名秀一朗、吉田晴彦、小池和彦
- Organizer
  第47回日本臨床分子医学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590960
[Presentation] microRNA機能に関わる分子DDX20の発現低下に伴うmicroRNA機能の減弱によって惹起される新しい肝発癌経路の同定2010
- Author(s)
  高田朱弥,大塚基之,小池和彦
- Organizer
  第46回日本肝臓学会総会
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-23590960
[Presentation] Functional impairment of microRNAs induced by chronic inflammation is a cause of inflammation-associated colon tumorigenesis in mice
- Author(s)
  Otsuka M
- Organizer
  The 2nd JSGE International Topic Conference
- Place of Presentation
  Kagoshima
- Invited
- Data Source
  KAKENHI-PROJECT-22390058
[Presentation] Functional impairment of microRNAs induced by chronic inflammation is the cause of inflammation-associated colon tumorigenesis
- Author(s)
  Otsuka M
- Organizer
  JST-CREST international symposium Frontiers in Immunology & Inflammation
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-22390058

1. MAEDA Shin (40415956)

# of Collaborated Projects: 6 results

# of Collaborated Products: 4 results
2. IJICHI Hideaki (70463841)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
3. YOSHIDA Haruhiko (60240305)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
4. KONDO Yuuji (00572231)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
5. Sato Masaya (30722665)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
6. YAMAMOTO Natsuyo (40599578)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 立石敬介 (20396948)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
8. 丸山玲緒 (60607985)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
9. HIRATA YOSHIHIRO (10529192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YAMADA Atsuo (80534932)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. GOTO Tadashi (40444088)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SHIBATA Wataru (00435819)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Ohnaga Takashi (10416133)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. 藤井努 (60566967)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 上田優輝 (90756074)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 冨樫庸介 (80758326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 渡辺彰吾 (20548341)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 小関泰之 (60437374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 廣畑聡 (90332791)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 岸川孝弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 8 results
21. 西川祐司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 加藤直也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 小池和彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 石橋嶺

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 加藤博也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 堤康一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 宮澤正顕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OTSUKA MOTOYUKI 大塚 基之

OTSUKA Motoyuki 大塚 基之

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膵癌における反復配列RNAの機能解析と治療選択最適化への応用Principal Investigator

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Identification of novel circular RNA in pancreatic cancerPrincipal Investigator

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RNA機能変化を端緒とした炎症細胞社会学の確立Principal Investigator

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Impairment of microRNA function and carcinogenetic risk by agingPrincipal Investigator

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Oncogenetic process by the complexed system due to heterochromatin-derived RNAPrincipal Investigator

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Multi-step carcinogenesis due to non-coding repetitive RNA expressionPrincipal Investigator

OTSUKA MOTOYUKI 大塚基之

OTSUKA Motoyuki 大塚基之