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NAGAI Kazuo  永井 和夫

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NAGAI KAZUO  永井 和夫

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Researcher Number 00011974
Other IDs
Affiliation (based on the past Project Information) *help 2001 – 2010: Chubu Univ., Fac. of Appl. Biol., Prof., 応用生物学部, 教授
2002: 中部大学, 応用生命学部, 教授
2000: Tokyo Institute of Technology, Graduate School of Bioscience and Biotechnology, Professor, 大学院・生命理工学研究科, 教授
1990 – 2000: 東京工業大学, 生命理工学部, 教授
1989: 東京工業大学, 工学部, 教授
1986 – 1987: TOKYO UNIVERSITY, ASSOCIATE PROFESSOR, 農学部, 助教授
1986: 東大, 農学部, 助手
Review Section/Research Field
Principal Investigator
応用微生物学・応用生物化学 / Applied biochemistry / 応用微生物学・発酵学 / 応用生物化学・栄養化学 / Science and Engineering / 発酵・醸造
Except Principal Investigator
Applied biochemistry / 応用微生物学・応用生物化学 / 遺伝学 / Applied microbiology / Science and Engineering / Biological pharmacy / 応用薬理学・医療系薬学
Keywords
Principal Investigator
破骨細胞 / reveromycin A / bone resorption / osteoclast / 骨吸収 / H-NS / oriC / osteoporosis / EGCG / 骨粗鬆症 … More / デストラクシン / destruxins / アポトーシス / 大腸菌 / 骨吸収抑制剤 / リベロマイシン / cell death / メバスタチン / 細胞死 / actin ring / apoptosis / レベロマイシン / 生存 / 分化 / 骨形成 / rRNA / ams / cafA / カルシウム / mre / SopA / 細胞周期 / 染色体複製 / 微生物代謝産物 / 免疫調節 / 生理活性物質 / 細胞複製 / triphenyltin / nepodin / curcumin / ルテオリン / ケルセチン / 代謝産物 / 有機スズ化合物 / フラボノイド / 植物代謝産物 / トリフェニルスズ / ネポジン / クルクミン / リベロマイシンA / inhibition / mevastatin / 選択作用 / 酸性環境 / tRNA / タンパク質合成 / 阻害 / calcium / 活性化 / ゲラニルゲラニル化 / 骨芽細胞 / カテキン / cell fusion / compactin / 抑制剤 / destruxin E / デストラキシン / コンパクチン / Bioprobe / Vacuolar type H^+-ATPase / Cytotoxic Tcell / Osteoclast / Bone metabolism / Immunomodulator / Biologically active compound / バイオプローブ / 液胞型H^+-ATPase / 細胞傷害性T細胞 / Cytoskeltal protein / Calcium / Cell cycle / Histone-like protein / 超ラセン構造 / DNA gyrase / アルコールデヒドロゲナーゼ / 細胞骨格様蛋白質 / ヒストン様蛋白質 / F plasmid / cell division / replication / Escherichia coli / HーNS / DNAー膜複合体 / sopA / oric / Fプラスミド / 細胞分裂 / DNA-膜複合体 / 細胞表層 / 生物時計 / 複製開始 / 原核細胞 / Prodigiosin / 細胞性免疫 / 免疫抑制 / 免疫修飾物質 / 細胞幼若化 / レクチン / ストレスファイバー / Green fluorescence protein / ルシフェラーゼ / 圧力刺激 / 有機溶媒 / heat shock protein / 電圧刺激 / ストレス応答 / 細胞骨格 / リポソーム / 圧力応答 / 酸化ストレス / 電気刺激 / サイトカイン / NF-κB / アクチン結合蛋白質 / 高圧応答細胞 / 活性酸素 / marRABオペロン / 分化誘導 / 電位印加 / アクチン / 細胞モデル / 加圧応答遺伝子 / 好圧性細菌 / 桿菌形態形成 / S-benzylisothiourea / mar遺伝子 / rpoSプロモーター / 抗酸化物質 / 抗がん物質 / 生薬成分 / 複製 / グリコ-ゲン・シンタ-ゼ / グリコ-ゲン / 染色体複製開始 … More
Except Principal Investigator
破骨細胞 / RANKL / プロテインホスファターゼ2C / reveromycin A / osteoporosis / bone resorption / osteoclast / 機能発現 / 骨吸収抑制剤 / 微生物代謝産物 / デストラクシン / 骨粗鬆症 / ATPase / Corynebacterium glutamicum / apoptosis / アポトーシス / PC12 / 大腸菌染色体 / 細胞・組織 / 生理活性 / 酵素 / 発生・分化 / シグナル伝達 / 破骨細胞分化因子 / プロテインホスファターゼ / ustiloxin / セントロメア / トポイソメラーゼ / SEX FACTOR / PARTITION OF DNA / PLASMID / 性決定因子 / DNAの分配 / プラスミド / osteoclasts / protein phosohatase / cells, tissues / biological activity / enzyme / development, differentiation / signal transduction / 破骨細胞分化誘導因子 / berberine / coptisine / compactin / destruxins / 骨密度 / 細胞骨格 / ベロマイシン / アルカロイド / 代謝産物 / ベロマイシンA / ベルベリン / コプチシン / コンパクチン / action mechanism / microbial metabolite / destruxin / 活性化 / 機能 / 分化 / 生存 / アポトーシツ / 作用機構 / リベロマイシン / 骨吸収 / γ -Glutamyltranspeptidase / Cell wall / Cysteine / Alanine / NADH dehydrogenase / Brevibacterium Oactofermentum / γ-グルタミルトランスフェラーゼ / 呼吸鎖 / γ-グルタミルトランスペプチターゼ / γ-グルタミルトランスペプチダーゼ / 細胞壁 / システイン / アラニン / NADH脱水素酵素 / ATP ase / environmental signal responsive cells / viability imaging / cell function analysis / single-cell / 機能評価 / 遺伝子発現制御 / イメージング技術 / ストレスシグナル応答 / 環境シグナル応答 / バイアビリティ / 環境シグナル応答細胞 / バイアビリティーイメージング / 細胞機能評価 / 単一細胞 / concanamycins / cell-differentiation / prodigiosins / nurite outgrowth (NOG) / V-ATPase / bafilomycins / デストラキシン / 突起伸展 / コンカナマイシン / 細胞分化 / プロジギオシン / 突起伸展(NOG) / プロトンポンプ / バフィロマイシン / emdin / kojou / cell cycle inhibition / Antioxdative activity / RRM activity / Yunnan Provience / cytotoxity / Antitumor activity / 雲南植物圏 / エモデイン / 虎杖 / 細胞周期阻害 / 抗酸化活性 / BRM活性 / 雲南植物園 / 細胞毒性 / 抗がん活性 / plasmid partitioning / centromere / DNA methylation / replication origin / cohesion of sister chromosomes / control of replication initiation / chromosome partitioning / chromosome segregation / ヒストン様蛋白 / 修飾環 / モーター蛋白 / プロテアーゼ / 細胞分裂 / ヒトセントロメア / 人工ミニ染色体 / 枯草菌 / ミニFプラスミドDNA / oriCDNA / 免疫蛍光顕微鏡法 / DnaA / SeqA / 複製開始 / 細胞周期 / プラスミド分配 / DNAメチレーション / 複製起点 / 姉妹染色体の対合 / 複製開始の調節 / 染色体分配 / 染色体分離 / プロティンホスファターゼ2C / enamidonin / nostodione A / isojaspisin / jaspisin / menoxymycin / cororubicin / tryprostatin / acetophthalidin / UK-1 / 紅花 / albuside A / arenastatin A / anguinomycin / 抗癌物質 / チューブリンへの作用 / アデノウイルス癌遺伝子 / di-n-buty1 malate / サイクロトリプロスタチン / スピロトリプロスタチン / curacin A / アポートシス / leptofuranin / resorcinin / 抗がん物質 / ヒストン脱アセチル化阻害剤 / trapoxin / malolactomycin / quinolidomicin / 分裂酵母 / 熱ショック転写因子 / ミニ染色体 / アルフォイドDNA / ヒト染色体 / FtsH蛋白 / MukB蛋白 Less
  • Research Projects

    (26 results)
  • Research Products

    (53 results)
  • Co-Researchers

    (51 People)
  •  Regulation of osteoclastogenesis by protein phosphatase 2C

    • Principal Investigator
      OHNISHI Motoko
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied biochemistry
    • Research Institution
      Chubu University
  •  Supperession of Osteoclast Differentiation by Protein Phosphatase 2C

    • Principal Investigator
      OHNISHI Motoko
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied biochemistry
    • Research Institution
      Chubu University
  •  The studies of action mechanism and pharmacological effect of anti-resorptive compounds that target osteocasts.Principal Investigator

    • Principal Investigator
      NAGAI Kazuo
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied biochemistry
    • Research Institution
      Chubu University
  •  A Search and their action mode of microbial bioactive compounds that inhibit osteoclastic Bone Resorption.

    • Principal Investigator
      WOO Je Tae
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied microbiology
    • Research Institution
      Chubu University
  •  A role of protein phosphatase 2C on osteoclast differentiation and activation

    • Principal Investigator
      OHNISHI Motoko
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied biochemistry
    • Research Institution
      Chubu University
  •  Effects of Low Molecular Weight Compounds on Osteoclastic Bone Resorption in vivo and in vitro.Principal Investigator

    • Principal Investigator
      NAGAI Kazuo
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied biochemistry
    • Research Institution
      Chubu University
  •  Studies on action mechanism of microbial metabolites that specifically inhibit osteoclastic bone resorption.

    • Principal Investigator
      WOO Je-tae
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      応用微生物学・応用生物化学
    • Research Institution
      Chubu University
  •  Low Molecular Weight Compounds That Regulate Bone MetabolismPrincipal Investigator

    • Principal Investigator
      NAGAI Kazuo
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      応用微生物学・応用生物化学
    • Research Institution
      Chubu University
  •  雲南地域の植物性抗がん剤に関する研究Principal Investigator

    • Principal Investigator
      永井 和夫
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Tokyo Institute of Technology
  •  環境シグナル応答細胞の創製Principal Investigator

    • Principal Investigator
      AIZAWA Masuo, 永井 和夫
    • Project Period (FY)
      1999 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Science and Engineering
    • Research Institution
      Tokyo Institute of Technology
  •  Supervision of the Research of Single-cell Molecular Technology

    • Principal Investigator
      MATSUOKA Hideaki
    • Project Period (FY)
      1999 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Science and Engineering
    • Research Institution
      Tokyo University of Agriculture and Technology
  •  Molecular Understanding of the Coryne-form Bacteria and its Industrial Application

    • Principal Investigator
      TOMTA Fusao
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      応用微生物学・応用生物化学
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Microbial metabolites that regulate osteoclast differentiation and functionPrincipal Investigator

    • Principal Investigator
      NAGAI Kazuo
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      応用微生物学・応用生物化学
    • Research Institution
      Tokyo Institute of Technology (TIT)
  •  Studies of Floral Antitumor Medicines in Yunnan Province

    • Principal Investigator
      NISHIMURA Toshio
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Teikyo University
  •  Search for cell-death inducing antitumor agents based on the anti-tumor activity of V-ATPase inhibitors

    • Principal Investigator
      OHKUMA Shoji
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Biological pharmacy
    • Research Institution
      Kanazawa University
  •  Studies on physiological functions of vacuolar type H^+-ATPase using low molecular weight probesPrincipal Investigator

    • Principal Investigator
      NAGAI Kazuo
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      応用微生物学・応用生物化学
    • Research Institution
      TOKYO INSTITUTE OF TECHNOLOGY
  •  Dynamics of chromosome partition apparatus

    • Principal Investigator
      HIRAGA Sota
    • Project Period (FY)
      1996 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Institute of Molecular Embryology and Genetics, Kumamoto University
  •  ゲノムの複製終結と分配制御

    • Principal Investigator
      HIRAGA Sota (平賀 壯太)
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kumamoto University
  •  新規天然抗がん物質の探索

    • Principal Investigator
      瀬戸 治男
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  新規構造を有する天然物由来抗癌物質に関する研究

    • Principal Investigator
      瀬戸 治男
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  Roles of protein phosphorylation, calcium ion and cytoskeltal proteins in bacterial cell cycle.Principal Investigator

    • Principal Investigator
      NAGAI Kazuo
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      応用微生物学・応用生物化学
    • Research Institution
      Tokyo Institute of Technology
  •  Studies on regulatory factors for bacterial cell cycle.Principal Investigator

    • Principal Investigator
      NAGAI Kazuo
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      応用微生物学・発酵学
    • Research Institution
      Tokyo Institute of Technology
  •  大腸菌oriCおよびforC領域を含む複合体の構造と機能Principal Investigator

    • Principal Investigator
      永井 和夫
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      発酵・醸造
    • Research Institution
      Tokyo Institute of Technology
  •  大腸菌oric領域を含む複合体の構造, 形成周期性および染色体複製開始との関連性Principal Investigator

    • Principal Investigator
      永井 和夫
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  マウス免疫細胞に選択的効果を有する微生物代謝産物の単離とその作用機構の解析Principal Investigator

    • Principal Investigator
      永井 和夫
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      応用生物化学・栄養化学
    • Research Institution
      The University of Tokyo
  •  Partition Mechanism of Plasmids and the Chromosome of Escherichia coli.

    • Principal Investigator
      HIRAGA SOTA
    • Project Period (FY)
      1984 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      遺伝学
    • Research Institution
      KUMAMOTO UNIVERSITY
      Kyoto University

All 2011 2010 2009 2008 2007 2006 2005 2004 2003

All Journal Article Patent

  • [Journal Article] a β-carboline alkaloid, inhibits osteoclast differentiation and bone resorption in vitro and in vivo.2011

    • Author(s)
      Yonezawa T, Hasegawa S, Asai M, Ninomiya T, Sasaki T, Cha BY, Teruya T, Ozawa H, Yagasaki K, Nagai K, Woo JT
    • Journal Title

      Eur J Pharmacol. 650(2-3)

      Pages: 511-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20580105
  • [Journal Article] Honokiol inhibits osteoclast differentiation and function in vitro.2010

    • Author(s)
      Hasegawa S, Yonezawa T, Ahn JY, Cha BY, Teruya T, Takami M, Yagasaki K, Nagai K, Woo JT
    • Journal Title

      Biol Pharm Bull. 33(3)

      Pages: 487-92

    • NAID

      130000248103

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20580105
  • [Journal Article] Phytochemicals that stimulate osteoblastic differentiation and bone formation.2010

    • Author(s)
      Woo JT , Yonezawa T, Nagai K
    • Journal Title

      J Oral Biosci. 52(1)

      Pages: 15-21

    • NAID

      10027105179

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20580105
  • [Journal Article] Palmatine attenuates osteoclast differentiation and function through inhibition of receptor activator of nuclear factor-κb ligand expression in osteoblast cells.2010

    • Author(s)
      Lee JW, Mase N, Yonezawa T, Seo HJ, Jeon WB, Cha BY, Nagai K, Woo JT
    • Journal Title

      Biol Pharm Bull. 33(10)

      Pages: 1733-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20580105
  • [Journal Article] Magnolol enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells.2009

    • Author(s)
      Choi SS, Cha BY, Lee YS, Yonezawa T, Teruya T, Nagai K, Woo JT
    • Journal Title

      Life Sci. 84(25-26)

      Pages: 908-14

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20580105
  • [Journal Article] An inhibitory effect of chrysoeriol on platelet-derived growth factor (PDGF)-induced proliferation and PDGF receptor signaling in human aortic smooth muscle cells.2009

    • Author(s)
      Cha BY, Shi WL, Yonezawa T, Teruya T, Nagai K, Woo JT
    • Journal Title

      J Pharmacol Sci. 110(1)

      Pages: 105-10

    • NAID

      10025736841

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20580105
  • [Journal Article] Antiresorptive microbial compounds that inhibit osteoclast differentiation, function and survival.2008

    • Author(s)
      Woo JT, Yonezawa T, Cha BY, Teruya T, Nagai K
    • Journal Title

      J Pharmacol Sci. 106(4)

      Pages: 547-554

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20580105
  • [Journal Article] Food-derived polyphenols that can prevent osteoporosis2007

    • Author(s)
      Woo JT, An ZY, Hasegawa S, Nagai K
    • Journal Title

      New Food Industry 49

      Pages: 24-38

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17380069
  • [Journal Article] Identification of two biologically crucial hydroxyl groups of (-)-epigallocatechin gallate in osteoclast culture.2007

    • Author(s)
      Nakagawa H, Hasumi K, Takami M, Aida-Hyugaji S, Woo JT, Nagai K, Ishikawa T, Wachi M.
    • Journal Title

      Biochem Pharmacol. 73

      Pages: 34-43

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17380069
  • [Journal Article] Tributyltin and triphenyltin inhibit osteoclast differentiation through a retinoic acid receptor-dependent signaling pathway.2007

    • Author(s)
      Yonezawa T, Hasegawa S, Ahn JY, Cha BY, Teruya T, Hagiwara H, Nagai K, Woo JT
    • Journal Title

      Biochem.Biophys.Res.Commun. 355

      Pages: 10-15

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17380069
  • [Journal Article] Identification of two biologically crucial hydroxyl groups of (-)epigallocatechin gallate in osteoclast culture.2007

    • Author(s)
      Nakagawa H, Hasumi K, Takami M, Aida-Hyugaji S, Woo JT, Nagai K, Ishikawa T, Wachi M
    • Journal Title

      Biochem Pharmacol. 73

      Pages: 34-43

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17380069
  • [Journal Article] 骨粗髪症予防機能性食品としての食品中のポリフェノール2007

    • Author(s)
      Woo JT, An ZY, Hasegawa S, Nagai K
    • Journal Title

      New Food Industry 49

      Pages: 24-38

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17380069
  • [Journal Article] Tributyltin and triphenyltin inhibit osteoclast differentiation through a retinoic acid receptor-dependent signaling pathway.2007

    • Author(s)
      Yonezawa T, Hasegawa S, Ahn JY, Cha BY, Teruya T, Hagiwara H, Nagai K, Woo JT
    • Journal Title

      Biophys. Res. Commun. 355

      Pages: 10-15

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17380069
  • [Journal Article] Tributyltin and triphenyltin inhibit osteoclast differentiation through a retinoic acid receptor-dependent signaling pathway.2007

    • Author(s)
      Yonezawa T, Hasegawa S, Ahn JY, Cha BY, Teruya T, Hagiwara H, Nagai K, Woo JT
    • Journal Title

      Biochem Biophys Res Commun 355

      Pages: 10-15

    • Data Source
      KAKENHI-PROJECT-17380069
  • [Journal Article] Identification of two biologically crucial hydroxyl groups of (-)-epigallocatechin gallate in osteoclast culture.2007

    • Author(s)
      Nakagawa H, Hasumi K, Takami M, Woo JT, Nagai K, Ishikawa T, Wachi M.
    • Journal Title

      Biochem Pharmacol 73

      Pages: 34-43

    • Data Source
      KAKENHI-PROJECT-17380069
  • [Journal Article] 骨粗鬆症予防機能性食品素材としての食品中のポリフェノール2007

    • Author(s)
      禹 済泰, 安 哉龍, 長谷川 森一, 永井和夫
    • Journal Title

      ニューフードインダストリー、New Food Industry 49(印刷中)

    • NAID

      40015449069

    • Data Source
      KAKENHI-PROJECT-17380069
  • [Journal Article] Curcumin inhibits the proliferation and mineralization of cultured osteoblasts.2006

    • Author(s)
      Notoya M, Nishimura H, Woo JT, Nagai K, Ishihara Y, Hagiwara H
    • Journal Title

      Eur J Pharmacol. 534

      Pages: 55-62

    • Data Source
      KAKENHI-PROJECT-16580065
  • [Journal Article] Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts.2006

    • Author(s)
      Woo JT, Kawatani M, Kato M, Shinki T, Stern PH, Nagai K, Osada H.
    • Journal Title

      Proc Natl Acad Sci U S A. 13. 103

      Pages: 4729-4734

    • Data Source
      KAKENHI-PROJECT-16580065
  • [Journal Article] Inhibitoion of osteoclast differentiation by nepodin isolated from Rumex japonicus2006

    • Author(s)
      Hasegawa H, Teruya T, Yonezawa T, Cha BY, K Nagai K, Woo JT
    • Journal Title

      J.JSMUFF 4

      Pages: 37-41

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17380069
  • [Journal Article] Inhibition of osteoclast differentiation by nepodin isolated from Rumex Japonicus ギシギシの根に含まれる破骨細胞初期分化抑制物質の単利と精製2006

    • Author(s)
      Hasegawa S, Teruya T, Yonezawa Y, Cha BY, Nagai K, Woo JT
    • Journal Title

      J. JSMUFF 4

      Pages: 37-41

    • Data Source
      KAKENHI-PROJECT-17380069
  • [Journal Article] Curcumin inhibits the proliferation and mineralization of cultured osteoblasts.2006

    • Author(s)
      Notoya M, Nishimura H, Woo JT, Nagai K, Ishihara Y, Hagiwara H
    • Journal Title

      Eur J Pharmacol. 534

      Pages: 55-62

    • Data Source
      KAKENHI-PROJECT-17380069
  • [Journal Article] ギシギシの根に含まれる破骨細胞初期分化抑制物質の単利と精製2006

    • Author(s)
      Hasegawa H, Teruya T, Yonezawa T, Cha BY, K Nagai K, Woo JT
    • Journal Title

      J. JSMUFF 4

      Pages: 37-41

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17380069
  • [Journal Article] Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts.2006

    • Author(s)
      Woo JT, Kawatani M, Kato M, Shinki T, Yonezawa T, Stern PH, Nagai K, Osada H
    • Journal Title

      Proc Natl Acad Sci USA 103

      Pages: 4729-4734

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17380069
  • [Journal Article] Curcumin inhibits the proliferation and mineralization of cultured osteoblasts.2006

    • Author(s)
      Notoya M, Nishimura H, Woo JT, Nagai K, Ishihara Y, Hagiwara H
    • Journal Title

      Eur J Pharmacol. 53

      Pages: 2006-2006

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17380069
  • [Journal Article] Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts.2006

    • Author(s)
      Woo JT, Kawatani M, Kato M, Shinki T, Yonezawa T, Kanoh N, Nakagawa H, Takami M, Lee KH, Stern PH, Nagai K, Osada H.
    • Journal Title

      Proc Natl Acad Sci USA. 103(12)

      Pages: 4729-4734

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16580065
  • [Journal Article] Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts.2006

    • Author(s)
      Woo JT, Kawatani M, Kato M, Shinki T, Stern PH, Nagai K, Osada H.
    • Journal Title

      Proc Natl Acad Sci U S A. 13. 103

      Pages: 4729-4734

    • Data Source
      KAKENHI-PROJECT-17380069
  • [Journal Article] Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts.2006

    • Author(s)
      Woo JT, Kawatani M, Kato M, Shinki T, Stern PH, Nagai K, Osada H.
    • Journal Title

      Proc Natl Acad Sci USA 103

      Pages: 4729-4734

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17380069
  • [Journal Article] Curcumin inhibits the proliferation and mineralization of cultured osteoblasts.2006

    • Author(s)
      Notoya M, Nishimura H, Woo JT, Nagai K, Ishihara Y, Hagiwara H, N.Udagawa, In-Sun Lee, Motoko Ohnishi, Hiromi Hagiwara, Kazuo Nagai
    • Journal Title

      Eur J Pharmacol. 534

      Pages: 55-62

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16580065
  • [Journal Article] Curcumin inhibits the proliferation and mineralization of cultured osteoblasts.2006

    • Author(s)
      Notoya M, Nishimura H, Woo JT, Nagai K, Ishihara Y, Hagiwara H.
    • Journal Title

      Eur J Pharmacol. 534

      Pages: 55-62

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16580065
  • [Journal Article] Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts.2006

    • Author(s)
      Woo JT, Kawatani M, Kato M, Shinki T, Lee KH, Stern PH, Nagai K, Osada H (他4人)Takami M, Lee KH, Stern PH, Nagai K, Osada H
    • Journal Title

      Proc Natl Acad Sci U S A. 13. 103

      Pages: 4729-4734

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16580065
  • [Journal Article] Statins and geranylgeranyl transferase I inhibitor inhibit mononuclear osteoclast formation induced by RANKL and TNF.2005

    • Author(s)
      Je-Tae Woo, Hiroshi Nakagawa, Annette M.Krecic, Kazuo Nagai
    • Journal Title

      Biochemical Pharmacology 69

      Pages: 87-95

    • Data Source
      KAKENHI-PROJECT-15380077
  • [Journal Article] Statins and geranylgeranyl transferase I inihibitor inhibit mononuclear osteoclast formation induced by RANKL and TNF.2005

    • Author(s)
      Je-Tae Woo, Hiroshi Nakagawa, Annette M.Krecic, Kazuo Nagai, Andrew D.Hamilton
    • Journal Title

      Biochemical Pharmacology, 69

      Pages: 87-95

    • Data Source
      KAKENHI-PROJECT-16580065
  • [Journal Article] Statins and geranylgeranyl transferase I inhibitor inhibit mononuclear osteoclast formation induced by RANKL and TNF.2005

    • Author(s)
      Je-Tae Woo, Hiroshi Nakagawa, Annette M.Krecic, Kazuo Nagai
    • Journal Title

      Biochemical Pharmacology 69

      Pages: 87-95

    • Data Source
      KAKENHI-PROJECT-16580065
  • [Journal Article] Statins and geranylgeranyl transferase I inihibitor inhibit mononuclear osteoclast formation induced by RANKL and TNF.2005

    • Author(s)
      Je-Tae Woo, Hiroshi Nakagawa, Annette M.Krecic, Kazuo Nagai, Andrew D.Hamilton
    • Journal Title

      Biochemical Pharmacology, 69

      Pages: 87-95

    • Data Source
      KAKENHI-PROJECT-17380069
  • [Journal Article] Statins and geranylgeranyl transferase I inihibitor inhibit mononuclearosteoclast formation induced by RNAKL and TNF2005

    • Author(s)
      J-T Woo, H.Nakagawa, A.M.Krecic, K.Nagai, A.D.Hamilton, S.M.Sebti, P.H.Stern
    • Journal Title

      Biochemical Pharmacology 69

      Pages: 87-95

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16580065
  • [Journal Article] Statins and geranylgeranyl transferase I inihibitor inhibit mononuclear osteoclast formation induced by RANKL and TNF.2005

    • Author(s)
      Je-Tae Woo, Hiroshi Nakagawa, Annette M.Krecic, Kazuo Nagai, Andrew D.Hamilton, Said M.Sebti, Paula H.Stern
    • Journal Title

      Biochemical Pharmacology, 69

      Pages: 87-95

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16580065
  • [Journal Article] Statins and geranylgeranyl transferase I inihibitor inhibit mononuclearosteoclast formation induced by RNAKL and TNF2005

    • Author(s)
      J-T Woo, H.Nakagawa, A.M.Krecic, K.Nagai, A.D.Hamilton S.M.Sebti, P.H.Stern
    • Journal Title

      Biochemical Pharmacology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15380077
  • [Journal Article] Statins and geranylgeranyl transferase I inihibitor inhibit mononuclear osteoclast formation induced by RANKL and TNF.2005

    • Author(s)
      Je-Tae Woo, Hiroshi Nakagawa, Annette M.Krecic, Kazuo Nagai, Andrew D.Hamilton, Said M.Sebti, Paula H.Stern
    • Journal Title

      Biochemical Pharmacology 69

      Pages: 87-95

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15380077
  • [Journal Article] Generation of hydrogen peroxide primarily contributes to the induction of Fe(II)-dependent apoptosis in Jurkat cells by (-)-epigallocatechin2004

    • Author(s)
      Nakagawa H, Hasumi K, Woo JT, Nagai K, Wachi M.
    • Journal Title

      Carcinogenesis 25

      Pages: 1567-1574

    • Data Source
      KAKENHI-PROJECT-16580065
  • [Journal Article] Quercetin suppresses bone resorption by inhibiting the differentiation and activation of osteoclasts.2004

    • Author(s)
      Woo, J.-T., Nakagawa, H., Notoya, M., Yonezawa, T., Udagawa, N., Lee, L.-S., Ohnishi, M., Hagiwara, H., Nagai, K.
    • Journal Title

      Biol. Pharm. Bull 27

      Pages: 504-509

    • NAID

      110003608794

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16580065
  • [Journal Article] Suppression of osteoprotegerin expression by prostaglandin E(2) is crucially involved in lipopolysaccharide-induced osteoclast formation.2004

    • Author(s)
      Suda K., Udagawa N., Sato N., Takami M., Itoh K., Woo, J.T, Takahashi N., Nagai K.
    • Journal Title

      J.Immunol. 172

      Pages: 2504-2510

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15380077
  • [Journal Article] Generation of hydrogen peroxide primarily contributes to the induction of Fe(II)-dependent apoptosis in Jurkat cells by (-)-epigallocatechin2004

    • Author(s)
      Nakagawa H, Hasumi K, Woo JT, Nagai K, Wachi M.
    • Journal Title

      Carcinogenesis 25

      Pages: 1567-1574

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15380077
  • [Journal Article] Quercetin suppresses bone resorption by inhibiting differentiation and activation of osteoclasts.2004

    • Author(s)
      J-T Woo, H Nakagawa, M Notoya, T Yonezawa, M Ohnishi, K.Nagai
    • Journal Title

      Biological Pharm.Bull 27

      Pages: 504-509

    • NAID

      110003608794

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16580065
  • [Journal Article] The calcineurin/ NFAT signaling pathway regulates osteoclastogenesis in RAW264.7 cells.2004

    • Author(s)
      Hirotani H, Tuohy NA, Woo JT, Stern PH, Clipstone NA, N.Udagawa, In-Sun Lee, Motoko Ohnishi, Hiromi Hagiwara, Kazuo.Nagai
    • Journal Title

      J.Biol.Chem. 279

      Pages: 13984-13992

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15380077
  • [Journal Article] Quercetin suppresses bone resorption by inhibiting differentiation and activation of osteoclasts.2004

    • Author(s)
      J -T Woo, H Nakagawa, M Notoya, T Yonezawa, M Ohnishi, K.Nagai
    • Journal Title

      Biological Pharm.Bull. 27

      Pages: 504-509

    • NAID

      110003608794

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15380077
  • [Journal Article] Suppression of osteoprotegerin expression by prostaglandin E(2) is crucially involved in lipopolysaccharide-induced osteoclast formation.2004

    • Author(s)
      Suda K., Udagawa N., Sato N., Takami M., Itoh K., Woo, J.T., Takahashi N., Nagai K.
    • Journal Title

      J.Immunol. 172

      Pages: 2504-2510

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15380077
  • [Journal Article] Generation of hydrogen peroxide primarily contributes to the induction of Fe(II)-dependent apoptosis in Jurkat cells by (-)- epigallocatechin gallate2004

    • Author(s)
      Nakagawa H, Hasumi K, Woo JT, Nagai K, Wachi M.
    • Journal Title

      Carcinogenesis 25

      Pages: 1567-1574

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16580065
  • [Journal Article] Quercetin suppresses bone resorption by inhibiting the differentiation and activation of osteoclasts2004

    • Author(s)
      Woo, J.-T., Nakagawa, H., Notoya, M., Yonezawa, T., Udagawa, N., Lee, I.-S., Ohnishi, M., Hagiwara, H., Nagai, K.
    • Journal Title

      Biol.Pharm.Bull. 27

      Pages: 504-509

    • NAID

      110003608794

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15380077
  • [Journal Article] Generation of hydrogen peroxide primarily contributes to the induction of Fe(II)-dependent apoptosis in Jurkat cells by(-)-epigallocatechin gallate.2004

    • Author(s)
      Nakagawa H, Hasumi K, Woo JT, Nagai K, Wachi M.
    • Journal Title

      Carcinogenesis. 25

      Pages: 1567-1574

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16580065
  • [Journal Article] Generation of hydrogen peroxide primarily contributes to the induction of Fe(H)-dependent apoptosis in Jurkat cells by (-)-epigallocatechin gallate2004

    • Author(s)
      Nakagawa H, Hasumi K, Woo JT, Nagai K, Wachi M.
    • Journal Title

      Carcinogenesis

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15380077
  • [Journal Article] Insulin-dependent adipogenesis in stromal ST2 cells drived from murine bone marrow.2003

    • Author(s)
      J.Ding, K.Nagai, J.T.Woo
    • Journal Title

      Biosci.Biotechnol.Biochem. 67

      Pages: 314-321

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15380077
  • [Patent] 破骨細胞分化抑制剤2008

    • Inventor(s)
      大西素子、永井和夫、禹済泰、木村賢一
    • Industrial Property Rights Holder
      学校法人中部大学、国立大学法人岩手大学
    • Industrial Property Number
      2008-219666
    • Filing Date
      2008-08-28
    • Data Source
      KAKENHI-PROJECT-20580105
  • [Patent] 骨吸収抑制剤2008

    • Inventor(s)
      大西素子, 木村賢一, 萬済泰, 永井和夫.
    • Industrial Property Rights Holder
      中部大学, 岩手大学
    • Industrial Property Number
      2008-219666
    • Filing Date
      2008-08-28
    • Data Source
      KAKENHI-PROJECT-20580105
  • 1.  WOO JaeーTae (20272693)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 51 results
  • 2.  OHNISHI Motoko (00312653)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 6 results
  • 3.  WACHI Masaaki (90192822)
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    # of Collaborated Products: 0 results
  • 4.  HIRAGA Sota (40027321)
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  • 5.  AIZAWA Masuo (00016742)
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  • 6.  OGURA Teru (00158825)
    # of Collaborated Projects: 2 results
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  • 7.  NISHIMURA Akiko (20142002)
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  • 8.  SAKUDA Shohei (80192087)
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  • 9.  NISHIMURA Toshio (10013327)
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  • 10.  MINAMI Motoyasu (90340207)
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  • 11.  加藤 潤一 (10194820)
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  • 12.  岡崎 恒子 (10022584)
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  • 13.  瀬戸 治男 (10013335)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  長田 裕之 (80160836)
    # of Collaborated Projects: 2 results
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  • 15.  岩崎 成夫 (00013326)
    # of Collaborated Projects: 2 results
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  • 16.  姚 新生
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  • 17.  OHYA Yoshikazu (20183767)
    # of Collaborated Projects: 1 results
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  • 18.  HORIUCHI Takashi (60108644)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  TSURUO Takashi (00012667)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  OHKUMA Shoji (10119563)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  SOMEI Masanori (20110546)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  YOKOYAMA Ken (70271377)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  ARAI Kunizo (50126562)
    # of Collaborated Projects: 1 results
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  • 24.  HATANAKA Yasumaru (30111181)
    # of Collaborated Projects: 1 results
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  • 25.  OHTA Tetsuo (09671290)
    # of Collaborated Projects: 1 results
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  • 26.  MATSUOKA Hideaki (10143653)
    # of Collaborated Projects: 1 results
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  • 27.  HORIKOSHI Koki (80087551)
    # of Collaborated Projects: 1 results
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  • 28.  KAWATA Satoshi (30144439)
    # of Collaborated Projects: 1 results
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  • 29.  IMACHI Ko (10010076)
    # of Collaborated Projects: 1 results
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  • 30.  MATSUE Tomokazu (70173797)
    # of Collaborated Projects: 1 results
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  • 31.  ANDO Joji (20159528)
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  • 36.  KUMAGAI Hidehiko (70027192)
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  • 37.  NAKAMORI Shigeru (00254243)
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  • 38.  丹羽 修身 (70144318)
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  • 39.  内藤 幹彦 (00198011)
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  • 41.  小林 昭雄 (30115844)
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  • 42.  池上 晋 (80011980)
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  • 43.  青野 力三 (30126643)
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  • 44.  宝谷 紘一 (80025444)
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  • 45.  松澤 洋 (00011966)
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  • 46.  孫 啓時
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  • 47.  邵 剛
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  • 51.  YAO Xin-sheng
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