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TAKEUCHI Toshiyuki  竹内 利行

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… Alternative Names

竹内 利行  タケウチ トシユキ

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Researcher Number 00109977
Other IDs
Affiliation (based on the past Project Information) *help 2013 – 2014: 群馬大学, 特任教授
2012: 群馬大学, その他部局等, 特任教授
2009 – 2011: Gunma University, 特任教授
2006 – 2007: 群馬大学, 生体調節研究所, 教授
2003: Gunma University, Institute for Molecular and Cellular Regulation, President, 生体調節研究所, 所長 … More
2003: 群馬大学, 生体調節研究所, 所長(研究職)
2002: Gunma University, Institution of molecular regulation, Professor, 生態調節研究所, 教授
1994 – 2002: Gunma University, Department of Molecular Medicine, Institute for Molecular and, 生体調節研究所, 教授
1999: 群馬大学, 医学部, 教授
1999: 群馬大学, 生体調整研究所, 教授
1999: Gunma University, Institute for Molecular and Cellular Regularion, Professor, 生体調節研究所・遺伝子発現分野, 教授
1993: Gunma Univ., Inst.for Mol.& Cell.Regulation, Professor, 生体調節研究所・遺伝子発現分野, 教授
1991 – 1993: 群馬大学, 内分泌研究所, 教授
1989 – 1993: 群馬大学, 内分泌研究所・化学構造部門, 教授 Less
Review Section/Research Field
Principal Investigator
Gastroenterology / 内分泌・代謝学 / 医学一般 / Chemical biology / Biomedical engineering/Biological material science / Living organism molecular science / Metabolomics / 応用薬理学・医療系薬学
Except Principal Investigator
Human genetics / Gastroenterology … More / Cerebral neurosurgery / 内分泌・代謝学 / Metabolomics / Neurophysiology and muscle physiology / 応用薬理学・医療系薬学 / Biological Sciences Less
Keywords
Principal Investigator
Furin / TGFβ / インスリン / ガストリン / PTHrP / TGFα / 膵β細胞 / Insulin / Processing / 主細胞 … More / 遺伝子導入マウス / 高ガストリン血症 / フューリン / PEPCK / Gastrin / プロセシング / Gene therapy / Proinsulin / 糖尿病治療 / 発光プローブ / インスリン発現 / MAPキナーゼ / 胃粘膜上皮 / 壁細胞 / 胃粘膜 / furin / Calpastatin / Calpain / Chief cells / Gastric surface mucous (GSM) cells / CCK-B / Gastrin receptor / TGFβRII受容体 / 胃主細胞 / 胃壁細胞 / 萎縮性胃炎 / 胃粘液上皮 / カルパスタチン / カルパイン / 被蓋上皮細胞 / ガストリン受容体 / MIN6 cells / Insulin secretion / Pancreatic β cells / TGF-β / フォスファターゼ / MIN6 / Insulin Secretion / Pencreatic β cells / Adenovirus vector / H4IIE細胞 / PEPCKプロモーター / 発現ベクター / PK / アデノウイルスベクター / Transgenic mouse / Hypertrophic growth / Gastric mucosa / TGFalpha / HK-ATPase / 胃粘膜肥厚 / カルボキシペプチダーゼ / プロインスリン / メタロサイオニンプロモ-タ- / インスリン遺伝子 / 成長ホルモン遺伝子 / 遺伝子導入 / 皮膚移植 / 小人症治療 / 遺伝子治療 / 成長ホルモン / Pancreatic polypeptide / Amidated peptide / 内分泌細胞 / 限定分解 / 膵ポリペプチド / アミド化ペプチド / 生体機能利用 / バイオテクノロジー / 深達度 / 長波長化 / 癌の面像診断 / 酸素濃度 / 二色発光 / 癌の画像診断 / In vivoイメージング / 酸素消光 / リン光 / 低酸素病態 / イリジウム錯体 / 有機EL / 分子イメージング / 内分泌顆粒 / ダンシル基 / ピレン基 / DAMP / アクリジンオレンジ / 蛍光プローブ / ペリレン / エキシマー効果 / ダンシル / ピレン / コレステロール / JNK / MAPキナーゼ特異的ホスファターゼ / ペプシノゲン / シアロムチン / EGFR / 胃粘膜上皮細胞 / 肥満 / α_1アンチトリプシン / 心筋肥大 / BNP / α1-アンチトリプシン / 前癌状態 / 胃癌 / アミド化反応 / アミド化カルシトニン / グリシン付加カルシトニン / 細胞医薬 / 限定切断 / 生理活性ペプチド / カルシトニン … More
Except Principal Investigator
adenovirus vector / p53 / nestin / glioma / gene therapy / インスリン分泌 / targeting / selective gene expression / HDC / ポジショナルクローニング / Fura-2 / AMPA / Interdigestive migrating contraction (IMC) / ガストリン / Naked plasmid DNA / Intravascular gene delivery / Glucose tolerance / Liver / Insulin / Portal circulation / Regenerative gene therapy / Diabetes mellitus / 遺伝子治療 / 再生医療 / 門派 / nakedプラスミドDNA / 経血管的遺伝子導入 / 耐糖能 / 肝臓 / インスリン / 門脈 / 遺伝子再生治療 / 糖尿病 / HSV-TK / loxP / Cre / adenovirus / gene theory / histamine / gastrin / 胃粘膜上皮細胞 / トランスジェニックマウス / 分化-増殖 / 被蓋上皮細胞 / 増殖 / 分化 / 胃粘膜 / ヒスタミン / CHROMOSOMAL MAPPING / GENE EXPRESSION / POSITIONAL CLONING / DATABASE / GENOME / 染色体マッピング / 遺伝子発見 / データベース / ゲノム / 膵β細胞容量 / 遺伝子 / ディファレンシャル・ディスプレイ法 / 膵α細胞 / 膵β細胞 / insulin secretion / transcription factor / early-onset diabetes mellitus / positional cloning / MODY3 / 連鎖解析 / 転写因子 / 若年発症型糖尿病 / ポジショナルクローリング / GENOME DATABASE / GLUCOKINASE / グルコースセンサー / 遺伝子データベース / グルコキナーゼ / peptide structure / peptide isolation / differentiation-inducing factor / growth factor / neuropeptide / hormone / biologically active peptide / ペプチド / 生理活性 / 構造決定 / 抽出精製 / 分化誘導因子 / 成長因子 / 神経ペプチド / ホルモン / 生理活性ペプチド / Patch-clamp / Clonal cell strain / Transfection / Expression vector / Kainate / Glutamate receptor / cDNA発現 / fura-2 / 発現プロモーター / cDNA / パッチクランプ法 / 培養細胞株 / 遺伝子導入 / 発現ベクター / カイニン酸 / グルタミン酸受容体 / 5HT_3 antagonist / Serotonin type 3 receptor (5HT_3 receptor) / 5-Hydroxytryptamine (5HT) / セロトニン受容体アンタゴニスト / セロトニン受容体 / シスプラチン / Smooth muscle cell contraction / Motilin / 腸間神経叢 / 腸管平滑筋 / 平滑筋収縮 / モチリン / Cre-loxP / PPARγ / ソマトスタチン / ガストリン受容体 / furin Less
  • Research Projects

    (34 results)
  • Research Products

    (54 results)
  • Co-Researchers

    (37 People)
  •  Study on mitochondrial respiratory chain function using a hypoxia-sensing luminescent iridium complex probePrincipal Investigator

    • Principal Investigator
      TAKEUCHI Toshiyuki
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Chemical biology
    • Research Institution
      Gunma University
  •  Research and development of hypoxia-detecting luminescent probe iridium complex and its application to endoscopic imaging probesPrincipal Investigator

    • Principal Investigator
      TAKEUCHI Toshiyuki
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      Gunma University
  •  生体膜コレステロール組成を感知する蛍光プローブの開発Principal Investigator

    • Principal Investigator
      竹内 利行
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Living organism molecular science
    • Research Institution
      Gunma University
  •  MAPキナーゼ特異的ホスファターゼが膵β細胞の高次機能を発現・維持する機構Principal Investigator

    • Principal Investigator
      竹内 利行
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Metabolomics
    • Research Institution
      Gunma University
  •  Regenerative Gene Therapy of Diabetes Mellitus

    • Principal Investigator
      MAZDA Osam
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Glioma-specific p53 gene expression by adenovirus vector

    • Principal Investigator
      ISHIUCHI Syogo, 栗原 秀行
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Gunma University
  •  PPARγのドミナントネガティブ変異体トランスジェニックマウスの大腸癌発現

    • Principal Investigator
      為本 浩至
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Gunma University
  •  Expression of highly differentiated functions in gastric mucosal cells by paracrine mechanisms between distinct cell-types and appearance of adherent property to H. pylori in inverse proportion to decline in their differentiated functionsPrincipal Investigator

    • Principal Investigator
      TAKEUCHI Toshiyuki
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Gunma University
  •  Kex2型酵素Furinがその基質切断を介して膵β細胞の増殖と分化を制御する機序Principal Investigator

    • Principal Investigator
      竹内 利行
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Gunma University
  •  胃粘膜 壁細胞に特異発現する増殖因子 活性化酵素フュリンが胃粘膜機能を構築する機序Principal Investigator

    • Principal Investigator
      竹内 利行
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Gunma University
  •  Gene Therapy with Glioma-specific gene expression adenovirus vector

    • Principal Investigator
      KURIHARA Hideyuki
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Gunma University
  •  Kex2型蛋白分解酵素Furinの発現によって胃粘膜上皮細胞が増殖する機序Principal Investigator

    • Principal Investigator
      竹内 利行
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Gunma University
  •  胃粘膜上皮細胞がガストリン受容体,Furin,TGFαを順次発現していく機序Principal Investigator

    • Principal Investigator
      竹内 利行
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Gunma University
  •  ガストリン刺激による胃被蓋上皮細胞ガストリン受容発現増加機序の研究

    • Principal Investigator
      KONDA Yoshitaka
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Kyoto University
  •  Kex2ファミリー蛋白分解酵素furinの発現によって心筋細胞が肥大する機序Principal Investigator

    • Principal Investigator
      竹内 利行
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Gunma University
  •  肥満を呈するガストリン遺伝子導入マウスにおいてガストリンが肥満を誘発する機序Principal Investigator

    • Principal Investigator
      竹内 利行
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Gunma University
  •  LARGE-SCALE COLLECTION OF PANCREATIC ISLET ESTS AND CHROMOSOMAL MAPPING

    • Principal Investigator
      TAKEDA Jun
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Human genetics
    • Research Institution
      GUNMA UNIVERSITY
  •  Gastrin controls growth and differentiation of mouse gastric pit cells.

    • Principal Investigator
      KONDA Yoshitaka
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      KYOTO UNIVERSITY
      Gunma University
  •  Studies on insulin secretory granule formation capacity by the control of proprotein-processing endoprotease furin.Principal Investigator

    • Principal Investigator
      TAKEUCHI Toshiyuki
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Gunma University
  •  Kex2ファミリー蛋白分解酵素Furinによる細胞高次機能の調節Principal Investigator

    • Principal Investigator
      竹内 利行
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Gunma University
  •  IDENTIFICATION OF THE GENE RESPONSIBLE FOR THE DEVELOPMENT OF FAMILIAL EARLY-ONSET DIABETES MELLITUS (MODY)

    • Principal Investigator
      TAKEDA Jun
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Human genetics
    • Research Institution
      GUNMA UNIVERSITY
  •  高次機能をもつ膵β細胞株の樹立とその機能を発現する遺伝子群解析システムの確立

    • Principal Investigator
      泉 哲郎
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Gunma University
  •  IDENTIFICATION OF THE GENES INVOLVED IN GLUCOSE-STIMULATED INSULIN SECRETION

    • Principal Investigator
      TAKEDA Jun
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Human genetics
    • Research Institution
      GUNMA UNIVERSITY
  •  Study on the precancerous gastric mucosa using gastrin-overexpressing transgenic micePrincipal Investigator

    • Principal Investigator
      TAKEUCHI Toshiyuki
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Gunma University, Institute for Molecular and Cellular Regulation
  •  Gene therapy of streptozotocin-induced diabetic rats with a regulatable insulin expression vectorPrincipal Investigator

    • Principal Investigator
      TAKEUCHI Toshiyuki
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Gunma University, Institute for Molecular and Cellular Regulation
  •  カルシトニン遺伝子を組み込んだ細胞医薬Principal Investigator

    • Principal Investigator
      竹内 利行
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Gunma University
  •  ガストリンによる胃粘膜肥厚作用と前癌状態-遺伝子導入マウスを用いた研究Principal Investigator

    • Principal Investigator
      竹内 利行
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Gunma University
  •  Search for novel hormones and neuropeptides

    • Principal Investigator
      TATEMOTO Kazuhiko
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Gunma University
  •  Processing of mutated proinsulin with tetrabasic cleavage sites to mature insulin in non-endocrine nell linesPrincipal Investigator

    • Principal Investigator
      TAKEUCHI Toshiyuki
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Gunma University
  •  An attempt to establish clonal cell strains expressing glutamate receptor channels.

    • Principal Investigator
      OZAWA Seiji
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Neurophysiology and muscle physiology
    • Research Institution
      Gunma University
  •  Molecular Biological Studies on the Action Mechanisms of Motilin and its Receptor

    • Principal Investigator
      ITOH Zen
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Gunma University
  •  Studies on the Inhibitory Mechanisms of Serotonin Type 3 Receptor Antagonists for Nausea and Vomitting Caused by Anti-cancer Chemotherapy Drugs

    • Principal Investigator
      ITOH Zen
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Gunma University
  •  Endocrine Cells and its Amidating CapabilityPrincipal Investigator

    • Principal Investigator
      TAKEUCHI Toshiyuki
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Gunma University
  •  Experimental Gene Therapy Utilizing a Skin TransplantPrincipal Investigator

    • Principal Investigator
      TAKEUCHI Toshiyuki
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      医学一般
    • Research Institution
      Gunma University

All 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation Book Patent

  • [Book] Synthesis of novel silylated pyrene units and theira application as a functional labeling agent for bioactive components such as oligoDNA and cholesterol, In Pyrene: Chemical Properties, Biochemistry Applications and Toxic Effects.2013

    • Author(s)
      Shinozuka K, Takeuchi T.
    • Total Pages
      23
    • Publisher
      Nova Scientific Publishers, Inc. NY, USA
    • Data Source
      KAKENHI-PROJECT-24651256
  • [Book] リン光プローブの設計・開発に基づくin vivo低酸素環境イメージング2012

    • Author(s)
      飛田成史、吉原利忠, 穂坂正博、竹内利行
    • Total Pages
      5
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Book] リン光プローブの設計・開発に基づくin vivo低酸素環境イメージング2012

    • Author(s)
      飛田成史, 吉原利忠, 穂坂正博, 竹内利行
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Journal Article] Intracellular and in vivo oxygen sensing using phosphorescent Ir(III) complexes with a modified acetylacetonato ligand2015

    • Author(s)
      Yoshihara T, Hosaka M, Terata M, Ichikawa K, Murayama S, Tanaka A, Mori M, Itabashi H, Takeuchi T, Tobita S.
    • Journal Title

      Anal. Chem.

      Volume: 87 Issue: 5 Pages: 2710-2717

    • DOI

      10.1021/ac5040067

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-23310157, KAKENHI-PROJECT-24651256, KAKENHI-PROJECT-25440052, KAKENHI-PLANNED-26111012, KAKENHI-PROJECT-26702011
  • [Journal Article] Mitochondrial Respiratory Function Induces Endogenous Hypoxia2014

    • Author(s)
      S. Prior, A. Kim, T. Yoshihara, S. Tobita, T. Takeuchi, and M. Higuchi
    • Journal Title

      PLoS One

      Volume: 9 Issue: 2 Pages: e88911-e88911

    • DOI

      10.1371/journal.pone.0088911

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23310157, KAKENHI-PROJECT-23500511, KAKENHI-PROJECT-24651256
  • [Journal Article] Silylation improves photodynamic activity of tetraphenylporphyrin derivative in vitro and in vivo.2014

    • Author(s)
      Horiuch H, Hosaka M, Mashio H,Ishida S, Kyushin S, Okutsu T, Takeuchi T, Hiratsuka H.
    • Journal Title

      Chemistry - A European J

      Volume: 20 Issue: 20 Pages: 1-8

    • DOI

      10.1002/chem.201303120

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24651256, KAKENHI-PROJECT-24655137, KAKENHI-PROJECT-25410083, KAKENHI-PROJECT-25440052, KAKENHI-PROJECT-26620023
  • [Journal Article] Ratiometric Molecular Sensor for Monitoring Oxygen Levels in Living Cells2012

    • Author(s)
      Yoshihara, T., Yamaguchi, Y., Hosaka, M., Takeuchi, T., Tobita, S.
    • Journal Title

      Angew Chem Int Ed Engl

      Volume: 51 Issue: 17 Pages: 4148-4151

    • DOI

      10.1002/anie.201107557

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21200077, KAKENHI-PROJECT-21300159, KAKENHI-PROJECT-23500511, KAKENHI-PROJECT-24651256
  • [Journal Article] A radiometric molecular sensor for monitoring oxygen levels of living cells2012

    • Author(s)
      Yoshihara T, Yamaguchi Y, Hosaka M, Takeuchi T, Tobita S
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 51 Pages: 4148-4151

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Journal Article] Cyclophilin C-associated protein regulation of microglia/macrophage functions via NFAT activation in focal cerebral ischemia2011

    • Author(s)
      Yamaguchi R, Hosaka M, Torii S, Hou N, Imai H, Saito N, Yoshimoto Y, Takeuchi T
    • Journal Title

      Brain Res

      Volume: 1397 Pages: 55-65

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Journal Article] Luminal interaction between phogrin and carboxypeptidase E assists their effective targeting into secretory granules2011

    • Author(s)
      Saito N, Takeuchi T, Kawano A, Hosaka M, Hou N, Torii S
    • Journal Title

      Traffic

      Volume: 12 Pages: 499-506

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Journal Article] Constitutive reactive oxygen species generation from autophagosome/lysosome in neuronal oxidative toxicity2010

    • Author(s)
      Kubota C, Torii S, Hou N, Saito N, Yoshimoto Y, Imai H, Takeuchi T
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 667-674

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Journal Article] Phosphorescent light-emitting iridium complexes serves as a hypoxia-sensing probe for tumor imaging in living animals.2010

    • Author(s)
      Zhang S, Hosaka M, Yoshihara T, Negishi K, Iida Y, Tobita S, Takeuchi T
    • Journal Title

      Cancer Research (In Press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Journal Article] Iridium complex, a phosphorescent light-emitting diode material2010

    • Author(s)
      Zhang S, Hosaka M, Yoshihara T, Negishi K, Iida Y, Tobita S, Takeuchi T
    • Journal Title

      serves as anovel tool for imaging hypoxic cancertissues Cancer Res

      Volume: 70 Pages: 4490-4498

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Journal Article] Phosphorescent light-emitting iridium complexes serves as a hypoxia-sensing probe for tumor imaging in living animals.2010

    • Author(s)
      Zhang S, Hosaka M, Yoshihara T, Negishi K, lida Y, Tobita S, Takeuchi T
    • Journal Title

      Cancer Research

      Volume: 70 Pages: 4490-4498

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Journal Article] Cholesterol biosynthetic intermediates enhance regulated insulin secretion and secretory granule formation in pancreatic-cells2010

    • Author(s)
      Tsuchiya M, Hosaka M, Moriguchi T, Zhang S-J, Suda M, Hashimoto-Yokota H, Shinozuka K, Takeuchi T
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 16-4705

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Journal Article] Cholesterol Analogs Labeled with Novel Silylated Fluorescent Compounds2009

    • Author(s)
      Moriguchi T, Hosaka M, Yosinari A, Ozaki A, Takeuchi T, Shinozuka K
    • Journal Title

      Chem Lett

      Volume: 38 Pages: 966-967

    • NAID

      10025547099

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Journal Article] Development of photodetection method of trmor using phosphorescence of iridium(III) complexes.2009

    • Author(s)
      Yoshihara T, Kasahara Y, Negishi K, Hosaka M, Takeuchi T, Tobita S
    • Journal Title

      Photomedicine and Photobiology 31

      Pages: 13-14

    • Data Source
      KAKENHI-PROJECT-21300159
  • [Journal Article] Sorting mechanism of peptide hormones to secretory granules by the lead of cholesterol-bindingprotenin.secretogranin III in endocrine cells2008

    • Author(s)
      Takeuchi T. and Hosaka. M.
    • Journal Title

      Current Diabetes Rev 4

      Pages: 31-38

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18651102
  • [Journal Article] Molecular probes for sensing the cholesterol composition of subcellular organelle membranes.2006

    • Author(s)
      Wang R, Hosaka M, Han L, Yokota-Hashimoto H, Suda M, Mitsushima D, Torii S, Takeuchi T
    • Journal Title

      BBA-Mol Cell Biol Lipids 1761

      Pages: 1169-1181

    • Data Source
      KAKENHI-PROJECT-18651102
  • [Patent] 含ケイ素蛍光化合物および該化合物を用いた蛍光標識剤2012

    • Inventor(s)
      篠塚和夫, 森口朋尚, 竹内利行, 穂坂正博
    • Industrial Property Rights Holder
      国立大学法人群馬大学
    • Acquisition Date
      2012-03-16
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Patent] 酸素濃度測定試薬および酸素濃度測定方法2012

    • Inventor(s)
      飛田成史, 吉原利忠, 竹内利行, 穂坂正博
    • Industrial Property Rights Holder
      国立大学法人群馬大学
    • Acquisition Date
      2012-02-24
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Patent] Novel compound and functional luminescent probe comprising the same2011

    • Inventor(s)
      飛田成史, 吉原利忠, 竹内利行, 穂坂正博
    • Industrial Property Rights Holder
      国立大学法人群馬大学
    • Filing Date
      2011
    • Overseas
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Patent] 含ケイ素置換基を導入した化合物、並びにそれを含む一重項酸素発生剤及び癌治療薬2011

    • Inventor(s)
      堀内宏明, 穂坂正博, 平塚浩司, 竹内利行, 久新荘一郎, 石田真太郎
    • Industrial Property Rights Holder
      国立大学法人群馬大学
    • Filing Date
      2011-09-02
    • Overseas
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Patent] 抗DNP抗体を用いたコレステロール結合体2011

    • Inventor(s)
      竹内利行, 穂坂正博
    • Industrial Property Rights Holder
      国立大学法人群馬大学
    • Acquisition Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Patent] 新規蛍光化合物およびそれを用いた細胞内コレステロールの検出方法2010

    • Inventor(s)
      吉原利忠, 穂坂正博, 竹内利行, 飛田成史
    • Industrial Property Rights Holder
      国立大学法人群馬大学
    • Industrial Property Number
      2010-005220
    • Filing Date
      2010-03-09
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Patent] 新規化合物およびそれを含む機能性プローブNovel compound and functional luminescent probe comprising same2010

    • Inventor(s)
      飛田成史, 吉原利忠, 穂坂正博, 竹内利行
    • Industrial Property Rights Holder
      国立大学法人群馬大学
    • Filing Date
      2010-04-22
    • Overseas
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Patent] コレステロール含有膜のコレステロール含量の測定方法2009

    • Inventor(s)
      竹内利行, 穂坂正博
    • Industrial Property Rights Holder
      国立大学法人群馬大学
    • Acquisition Date
      2009-11-13
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Patent] 新規錯体化合物、並びにそれを用いた酸素濃度測定試薬および癌の診断薬2009

    • Inventor(s)
      飛田成史, 吉原利忠, 竹内利行, 穂坂正博
    • Industrial Property Rights Holder
      国立大学法人群馬大学
    • Industrial Property Number
      2009-166878
    • Filing Date
      2009-07-15
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Patent] 新規化合物およびそれを含む機能性発光プローブ分野2009

    • Inventor(s)
      吉原利忠、飛田成史、穗坂正博、竹内利行
    • Industrial Property Rights Holder
      国立大学 法人 群馬大学
    • Industrial Property Number
      2008-269005
    • Filing Date
      2009-10-16
    • Overseas
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Patent] 新規化合物およびそれを含む酸素濃度に依存して発光色が変化する機能性プローブ2009

    • Inventor(s)
      飛田成史, 吉原利忠, 竹内利行, 穂坂正博
    • Industrial Property Rights Holder
      国立大学法人群馬大学
    • Industrial Property Number
      2010-533937
    • Filing Date
      2009-10-16
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Patent] Novel compound and functional luminescent probe comprising the same2009

    • Inventor(s)
      飛田成史, 吉原利忠, 竹内利行, 穂坂正博
    • Industrial Property Rights Holder
      国立大学法人群馬大学
    • Filing Date
      2009-10-16
    • Overseas
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Patent] 酸素濃度測定試薬および酸素濃度測定方法2007

    • Inventor(s)
      竹内, 他
    • Industrial Property Rights Holder
      群馬大学
    • Filing Date
      2007-05-11
    • Data Source
      KAKENHI-PROJECT-18651102
  • [Patent] 抗DNP抗体を用いたコレステロール結合剤2007

    • Inventor(s)
      竹内, 他
    • Industrial Property Rights Holder
      群馬大学
    • Filing Date
      2007-08-21
    • Data Source
      KAKENHI-PROJECT-18651102
  • [Patent] 含ケイ素蛍光化合物および該化合物を用いた蛍光標識剤2007

    • Inventor(s)
      篠塚, 森口, 竹内, 穂坂
    • Industrial Property Rights Holder
      国立大学法人群馬大学
    • Industrial Property Number
      2007-075414
    • Filing Date
      2007-03-30
    • Data Source
      KAKENHI-PROJECT-18651102
  • [Patent] 新規蛍光化合物およびそれを用いた細胞内コレステロールの検出方法2007

    • Inventor(s)
      竹内, 他
    • Industrial Property Rights Holder
      群馬大学
    • Filing Date
      2007-04-19
    • Data Source
      KAKENHI-PROJECT-18651102
  • [Patent] 新規蛍光化合物およびそれを用いた細胞内コレステロールの検出方法2007

    • Inventor(s)
      竹内, 他
    • Industrial Property Rights Holder
      群馬大学
    • Filing Date
      2007-10-05
    • Data Source
      KAKENHI-PROJECT-18651102
  • [Patent] 含ケイ素蛍光化合物および該化合物を用いた蛍光標識剤2006

    • Inventor(s)
      篠塚, 森口, 竹内, 穂坂
    • Industrial Property Rights Holder
      国立大学法人群馬大学
    • Industrial Property Number
      2006-276757
    • Filing Date
      2006-10-10
    • Data Source
      KAKENHI-PROJECT-18651102
  • [Presentation] ミトコンドリア局在性を示すカチオン性イリジウム錯体を用いた生細胞イメージング。2014

    • Author(s)
      吉原忠利、村山沙織、菊池俊毅、竹内利行、飛田成史
    • Organizer
      第2回低酸素研究会
    • Place of Presentation
      早稲田、東京
    • Year and Date
      2014-07-26
    • Data Source
      KAKENHI-PROJECT-24651256
  • [Presentation] 低酸素組織の光イメージングを目指したジピリナート類を配位子に有する近赤外りん光イリジウム錯体の開発2013

    • Author(s)
      吉原利忠、八木橋美樹、田中亜沙美、寺田幹、穂坂正博、竹内利行、飛田成史
    • Organizer
      第8回日本分子イメージング学会
    • Place of Presentation
      横浜
    • Invited
    • Data Source
      KAKENHI-PROJECT-24651256
  • [Presentation] Iridium complex probes for monitoring of cellular oxygen levels and imaging of hypoxic tissues2012

    • Author(s)
      Tobita S, Yoshihara T, Kobayashi A, ichikawa K, Hosaka M, Takeuchi T
    • Organizer
      BiOS SPIE Photonics West
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2012-01-24
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Presentation] Phosphorescent iridium complexes with high cellular uptake efficiency for intracellular and in vivo oxygen measurements.2012

    • Author(s)
      Tobita S, Yoshihara T, Ichikawa K, Murayama S, Hosaka M, Takeuchi T.
    • Organizer
      XXIV IUPAC Symposium on Photochemistry
    • Place of Presentation
      Coimba Portugal
    • Data Source
      KAKENHI-PROJECT-24651256
  • [Presentation] Phosphorescence imaging of tumor using iridium complexes.2012

    • Author(s)
      Yoshihara T, Hosaka M, Takeuchi T, Tobita S.
    • Organizer
      14th International Congress of Histochemistry and Cytochemistry
    • Place of Presentation
      Kyoto, Japan
    • Invited
    • Data Source
      KAKENHI-PROJECT-24651256
  • [Presentation] Iridium complex probes for monitoring of cellular oxygen levels and imaging of hypoxic tissues2012

    • Author(s)
      Tobita S, Yoshihara T, Kobayashi A, ichikawa K, Hosaka M, Takeuchi T
    • Organizer
      BiOS SPIE Photonics West
    • Place of Presentation
      San Francisco
    • Year and Date
      2012-01-24
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Presentation] In vivoりん光寿命計測による低酸素組織内酸素レベルの可視化2011

    • Author(s)
      飛田成史, 小林敦, 吉原利忠, 穂坂正博, 竹内利行
    • Organizer
      日本分子イメージング学会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2011-05-26
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Presentation] Phosphorescent light-emitting iridium complexes serves as a hypoxiasensingprobe for tumor imaging in living animals2010

    • Author(s)
      Takeuchi T, Zhang S, Negishi K, Yoshihara T, Hosaka M, Tobita S
    • Organizer
      BiOS SPIE Photonics West
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2010-01-25
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Presentation] Phosphorescent light-emitting iridium complexes serves as a hypoxia-sensing probe for tumor imaging living animals2010

    • Author(s)
      Takeuchi T, Zhang S, Negishi K, Yoshihara T, Hosaka M, Tobita S.
    • Organizer
      BiOS SPIE Photonics West
    • Place of Presentation
      San Francisco, U.S.A.
    • Year and Date
      2010-01-25
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Presentation] イリジウム錯体のリン光を利用した癌の光検出法の開発2009

    • Author(s)
      吉原利忠, 根岸一也, 伏屋昌則, 穂坂正博, 張少娟, 竹内利行, 飛田成史
    • Organizer
      日本光医学会・光生物学会
    • Place of Presentation
      大阪梅田スカイビル
    • Year and Date
      2009-07-24
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Presentation] イリジウム錯体のリン光を利用した癌の光検出法の開発2009

    • Author(s)
      吉原利忠、根岸一也、伏屋昌則、穗坂正博、張少娟、竹内利行、飛田成史
    • Organizer
      日本光医学会・光生物学会
    • Place of Presentation
      大阪梅田スカイピル
    • Year and Date
      2009-07-24
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Presentation] イリジウム錯体のリン光を用いた癌などの低酸素組織イメージング2009

    • Author(s)
      飛田成史、吉原利忠、穗坂正博、張少娟、飯田靖彦、遠藤啓吾、竹内利行
    • Organizer
      日本分子イメージング学会
    • Place of Presentation
      東京一橋学術総合センター
    • Year and Date
      2009-05-14
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Presentation] 低酸素環境感知プローブイリジウム錯体による腫瘍イメージング2009

    • Author(s)
      穗坂正博、吉原利忠、張少娟、飯田靖彦、遠藤啓吾、飛田成史、竹内利行
    • Organizer
      日本生化学会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-21300159
  • [Presentation] Photophysical Properties of cationic Iridium complexes with mitochondrial speficity and their intracellular behavior.

    • Author(s)
      Yoshihara T, Murayama T, Kikuchi T, Takeuchi T, Tobita S.
    • Organizer
      The XXVth IUPAC Symposium on Photochemistry
    • Place of Presentation
      Bordeau, France
    • Year and Date
      2014-07-13 – 2014-07-18
    • Data Source
      KAKENHI-PROJECT-24651256
  • [Presentation] Intracellular oxygen measurements by using phosphorescent Iridium(III) complexes.

    • Author(s)
      Tobita S, Yoshihara T, Masuda T, Fujikura D, Kikuchi R, Hosaka M, Takeuchi T.
    • Organizer
      The XXVth IUPAC Symposium on Photochemistry
    • Place of Presentation
      Bordeau, France
    • Year and Date
      2014-07-13 – 2014-07-18
    • Data Source
      KAKENHI-PROJECT-24651256
  • [Presentation] リン光プローブを用いた低酸素細胞・組織イメージング技術の開発

    • Author(s)
      飛田成史、吉原利忠、増田剛、畠山泰典、藤倉大地、菊池亮平、穂坂正博、竹内利行
    • Organizer
      第53回生体医工学大会
    • Place of Presentation
      仙台
    • Year and Date
      2014-06-24 – 2014-06-26
    • Invited
    • Data Source
      KAKENHI-PROJECT-24651256
  • [Presentation] ゲートICCDカメラを用いたリン光寿命計測に基づくin vivo酸素イメージング。

    • Author(s)
      畠山泰典、増田剛、高橋一平、吉原忠利、穂坂正博、竹内利行、飛田成史
    • Organizer
      第9回日本分子イメージング学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-05-22 – 2014-05-23
    • Data Source
      KAKENHI-PROJECT-24651256
  • 1.  IZUMI Tetsurou (00212952)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 2.  TAKEDA Jun (40270855)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  TAKAGI Hitoshi (20251093)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  KONDA Yoshitaka (90261867)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  ITOH Zen (00008294)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  KOJIMA Itaru (60143492)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  ISHIKAWA Hidekazu (70008233)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  CHIBA Tsutomu (30188487)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  TOBITA Seiji (30164007)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 26 results
  • 10.  SUGANO Kentaro (60179116)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  TATEMOTO Kazuhiko (60240694)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  KURIHARA Hideyuki (30261853)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  ISHIUCHI Syogo (10312878)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  HOSAKA Masahiro (80311603)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 18 results
  • 15.  TORII Seiji (40312904)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  KOGURE Kimitaka (80143220)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  HORIUCHI Ryuya (90008342)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  KOHAMA Kazuhiro (30101116)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  KONDOH Youichi (70008598)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  NIIJIMA Akira (20018287)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  OZAWA Seiji (40049044)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  KAWAZU Shoji (30134547)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  MAZDA Osam (00271164)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  中島 孝 (20124422)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  為本 浩至 (90292630)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  的崎 尚 (80252782)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  篠塚 和夫 (20206105)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  青山 伸郎 (30243299)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  田中 滋康 (90146233)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  田村 勝 (50163697)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  小林 聡 (00265779)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  LEBEAU Michelle M.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  山内 広世
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  高橋 健一郎
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  BELL Greame
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  BELL Graeme I.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  YOSHIHARA Toshitada
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results

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* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

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