OSHIMA Yoshiteru 大島吉輝

Researcher Number	00111302
Other IDs
Affiliation (Current)	2025: 東北大学, オープンイノベーション戦略機構, 特任教授
Affiliation (based on the past Project Information) *help	2018: 東北大学, 医学系研究科, 特任教授(客員) 2016 – 2017: 東北大学, 薬学研究科, 教授 2014 – 2016: 東北大学, 大学院薬学研究科, 教授 2011 – 2015: 東北大学, 薬学研究科(研究院), 教授 2013: 東海大学, 薬学部, 教授 … More 2007 – 2012: Tohoku University, 大学院・薬学研究科, 教授 2010 – 2011: 東北大学, 薬学部, 教授 2006: 東北大学, 大学院薬学研究科, 教授 1999 – 2005: 東北大学, 大学院・薬学研究科, 教授 1996 – 1998: 東北大学, 薬学部, 教授 Less
Review Section/Research Field	Principal Investigator Natural medicines / Chemical pharmacy / Living organism molecular science / Bioorganic chemistry / Biological Sciences / Science and Engineering / Drug development chemistry Except Principal Investigator Biological pharmacy / Chemical pharmacy / Infectious disease medicine … More / Pharmacology in pharmacy / General pharmacology / General pharmacology / General internal medicine (including Psychosomatic medicine) Less
Keywords	Principal Investigator 自然免疫 / アルカロイド / 天然物 / フェブリフジン / 抗マラリア作用 / 常山 / 二次代謝物 / 昆虫寄生菌 / 昆虫 / エピジェネティクス … More / 糸状菌 / 抗マラリア剤 / 生物試験法 / 微生物 / 生薬 / 甘松香 / Dichroa febrifuga / エピジェネシス / 未利用遺伝子 / 酵素阻害剤 / 薬剤開発 / 副作用 / 植物 / 代謝物 / ショウジョウバエ / 昆虫共生菌 / アッセイ法 / 細胞性粘菌 / テルペノイド / 薬理活性 / 化合物ライブラリー / 天然物類縁体 / 多様性拡大抽出物 / 耐性菌 / リボソーム / リボソーム工学 / 休眠遺伝子 / analog / febrifugine / alkaloid / antimalarial drug / 誘導体 / Antimalarial activity / Febrifugine / Alkaloid / Screening System / Insect / Innate Immunity / 粘菌 / ditepenoid / NGF synthesis / Sarcodon scabrosus / anti-parkinsonian screening / sesquiterpenoid / antidepressant activity / Nardostachys chinensis / 活性成分 / 抗うつ試験 / カタレプシ-テスト / ポールテスト / ジテルペノイド / 神経成長因子 / ケロウジ / 抗パーキンソン薬 / セスキテルペノイド / 鎮痛作用 / 抗うつ薬 / 植物細胞 / ケミカルスペース / 化学変換 / 構造多様性 / ケミカルエピジェネティクス / 天然物創出 / 未利用生合成遺伝子 / 培養 / エピジェネティックス / 哺乳類 / 制御物質 / 環状化合物 / 自然免役 / リード化合物 / 構造活性相関 / 代謝 / 遺伝子導入 / 転写・翻訳阻害 / 細胞毒性 / α-ピロン化合物 / DIF-1 / 分化誘導因子 … More Except Principal Investigator DIF / トリパノソーマ / 免疫 / 糖尿病 / がん / 細胞性粘菌 / 走化性運動 / ミトコンドリア / 天然物 / 化学合成 / 薬学 / ウイルス / 感染症 / 細胞分化 / 抗菌剤 / 転移阻害剤 / 抗がん剤 / 創薬 / bioactive natural products / calcium release / muscle contraction / intracellular calcium / L6細胞 / 機械的刺激 / Ca遊離 / リアノジン受容体 / 天然生理活性物質 / カルシウム遊離 / 筋収縮 / 細胞内カルシウムイオン / セルソーティング / 多分化能 / 脊柱靭帯骨化症 / 形質転換 / 薬物治療 / 骨分化能 / エピジェネティクス / ニッチ / 脊柱靭帯 / 異所性骨化 / 間葉系幹細胞 / マイクロアレー / マイクロアレイ / 遺伝子 / センノシド / マウス / 線虫 / 寿命延長 / 抗加齢 / バイオマーカー / ダイオウ / 分化誘導因子 / indole alkaloid / anti-HSV-1 / Malaysian medicinal plant / cytotoxic / 脱顆粒抑制作用 / prolyl endopeptidase / opioid agonist / antioxidant / 人工培養 / 野外採取 / 持続的供給 / 新分子 / 環境保全 / 資源化 / 未利用菌類 Less

多様性拡大抽出物を活用した薬理活性志向型天然化合物類縁体ライブラリーの構築Principal Investigator
- Principal Investigator
  
  大島吉輝
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Natural medicines
- Research Institution
  Tohoku University
Novel screenings for unmet medical needs with innovative new natural product derived compounds
- Principal Investigator
  
  Kodama Eiichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Tohoku University
Research on pharmacologically active molecule DIF found in the cellular slime mold Dictyostelium discoieum
- Principal Investigator
  
  Kubohara Yuzuru
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Juntendo University
Use of Fungal Strains Resistant to Ribosome Targeting-Antibiotics for Discovery of Cryptic Secondary MetabolitesPrincipal Investigator
- Principal Investigator
  
  OSHIMA Yoshiteru
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Natural medicines
- Research Institution
  Tohoku University
Discovery of Novel Natural Products from Fungi by Epigenetic Expression of Secondary Metabolite Biosynthetic GenesPrincipal Investigator
- Principal Investigator
  
  Oshima Yoshiteru
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Natural medicines
- Research Institution
  Tohoku University
Search for plant-origin natural products by epigenetics-modifying chemicalsPrincipal Investigator
- Principal Investigator
  
  OSHIMA Yoshiteru
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Natural medicines
- Research Institution
  Tohoku University
Study on the bio-active molecule, DIF, found in the cellular slime mold Dictyostelium discoideum
- Principal Investigator
  
  Kubohara Yuzuru
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Juntendo University
  Gunma University
Role of mesenchymal stem cells as a cause of ectopic ossification of spinal ligament
- Principal Investigator
  
  FURUKAWA Ken-Ichi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Hirosaki University
Search for novel natural products using chemical inhibitors modifying epigenticsPrincipal Investigator
- Principal Investigator
  
  OSHIMA Yoshiteru
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Living organism molecular science
- Research Institution
  Tohoku University
Construction of molecular basis and clinical application of Kampo medicine
- Principal Investigator
  
  ARAI Makoto
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Tokai University
Development of Natural Product-Derived Innate Immune Regulators Using Insect Immune SystemsPrincipal Investigator
- Principal Investigator
  
  OSHIMA Yoshiteru
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Tohoku University
Study on the bio-active molecule, DIF, found in the soil micro-organism Dictyostelium discoideum
- Principal Investigator
  
  KUBOHARA Yuzuru
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Gunma University
Search for Natural Products Regulating Innate Immunity and Analysis of Their Mode of ActionsPrincipal Investigator
- Principal Investigator
  
  OSHIMA Yoshiteru
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Tohoku University
天然物由来の自然免疫制御物質の創製Principal Investigator
- Principal Investigator
  
  大島吉輝
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Tohoku University
植物アルカロイド・フェブリフジンの生体代謝物を鍵物質とする新規抗マラリア剤の創製Principal Investigator
- Principal Investigator
  
  大島吉輝
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Exploration of a New Type of Pharmacologically Active Compounds Based on Quinazoline-type Alkaloid, FebrifuginePrincipal Investigator
- Principal Investigator
  
  OSHIMA Yoshiteru
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  TOHOKU UNIVERSITY
植物アルカロイド・フェブリフジンの生体代謝物を鍵物質とする新規抗マラリア剤の開発Principal Investigator
- Principal Investigator
  
  大島吉輝
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
益々重要性が認識されつつある天然医薬資源の健康科学への拡大応用に関する調査研究
- Principal Investigator
  
  野原稔弘
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University
自然免疫機構解明に役立つ天然分子プローブの探索Principal Investigator
- Principal Investigator
  
  大島吉輝
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Tohoku University
遺伝子組換え昆虫を利用した,昆虫共生・寄生微生物の自然免疫活性物質の探索 ―新生物試験法を利用した新天然資源の開拓―Principal Investigator
- Principal Investigator
  
  大島吉輝
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Tohoku University
自然免疫に影響を及ぼす天然資源の探索Principal Investigator
- Principal Investigator
  
  大島吉輝
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Tohoku University
未利用菌類の資源化による新分子の発見と環境保全型物質生産
- Principal Investigator
  
  石橋正己
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Chiba University
Screening and characterization of new regulation factor of Ca^<2+> release channels
- Principal Investigator
  
  FURUKAWA Ken-ichi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Hirosaki University
Construction of New Biological Screening System Using Insects and Search for Biologically Active Substances from Natural SourcesPrincipal Investigator
- Principal Investigator
  
  OSHIMA Yoshiteru
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tohoku University
Development of Novel Antimalarial Drugs Based on Plant AlkaloidsPrincipal Investigator
- Principal Investigator
  
  OSHIMA Yoshiteru
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tohoku University
植物アルカロイドを起点とする新規抗マラリア薬の開発Principal Investigator
- Principal Investigator
  
  大島吉輝
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
細胞性粘菌分化誘導因子DIF-1を用いたボディープランの解析Principal Investigator
- Principal Investigator
  
  大島吉輝
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Tohoku University
新規な抗マラリア薬創製に役立つ天然資源成分の探索Principal Investigator
- Principal Investigator
  
  大島吉輝
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
天然資源からの新規な骨格を有する抗マラリア剤開発のためのリ-ド化合物の探索Principal Investigator
- Principal Investigator
  
  大島吉輝
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
RESEARCH ON NEW SKELETAL NATURAL PRODUCTS AFFECTING THE CENTRAL NERVOUS SYSTEMPrincipal Investigator
- Principal Investigator
  
  OSHIMA Yoshiteru
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  TOHOKU UNIVERSITY

[Journal Article] Derivatives of <i>Dictyostelium</i> Differentiation-Inducing Factors Inhibit Serum-Dependent Cell Migration of Murine Osteosarcoma LM8 Cells2019
- Author(s)
  Kubohara Y, Kikuchi H, Oshima Y.
- Journal Title
  
  Juntendo Medical Journal
  
  Volume: 65 Issue: 1 Pages: 71-76
- DOI
  10.14789/jmj.2019.65.JMJ18-OA10
- NAID
  130007631916
- ISSN
  2187-9737, 2188-2126
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07964
[Journal Article] Use of plant hormones to activate silent polyketide biosynthetic pathways in Arthrinium sacchari, a fungus isolated from a spider2019
- Author(s)
  Yohei Morishita, Yusuke Okazaki, Yi Yi Luo, Jun Nunoki, Tohru Taniguchi, Yoshiteru Oshima, Teigo Asai
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 17 Issue: 4 Pages: 780-784
- DOI
  10.1039/c8ob02837k
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05428, KAKENHI-PROJECT-16H05346, KAKENHI-PROJECT-17J02635, KAKENHI-PROJECT-18H02093, KAKENHI-PROJECT-19H03701
[Journal Article] Construction of a Meroterpenoid‐Like Compounds Library Based on Diversity‐Enhanced Extracts2018
- Author(s)
  Kikuchi Haruhisa、Kawai Kosuke、Nakashiro Yota、Yonezawa Takayuki、Kawaji Kumi、Kodama Eiichi. N.、Oshima Yoshiteru
- Journal Title
  
  Chemistry- A European Journal
  
  Volume: 25 Issue: 4 Pages: 1106-1112
- DOI
  10.1002/chem.201805417
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H03279, KAKENHI-PROJECT-16H05346
[Journal Article] Production of Novel Bispyrone Metabolites in the Cellular Slime Mold Dictyostelium giganteum Induced by Zinc(II) Ion2017
- Author(s)
  Van Hai Nguyen, Haruhisa Kikuchi, Hikaru Sasaki, Kyoichi Iizumi, Yuzuru Kubohara, Yoshiteru Oshima
- Journal Title
  
  Tetrahedron
  
  Volume: 73 Issue: 5 Pages: 583-588
- DOI
  10.1016/j.tet.2016.12.040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H03279, KAKENHI-PROJECT-15K07964
[Journal Article] Synthsis, and Biological Activity of Chlorinated Alkylresorcinols from Dictyostelium Cellular Slime Molds2017
- Author(s)
  Haruhisa Kikuchi, Ikuko Ito, Katsunori Takahashi, Hirotaka Ishigaki, Kyoichi Iizumi, Yuzuru Kubohara, Yoshiteru Oshima
- Journal Title
  
  Journal of Natural Products
  
  Volume: 80 Issue: 10 Pages: 2716-2722
- DOI
  10.1021/acs.jnatprod.7b00456
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H03279, KAKENHI-PROJECT-15K07964
[Journal Article] Biological Activities of Novel Derivatives of Differentiation-Inducing Factor 3 from <i>Dictyostelium discoideum</i>2017
- Author(s)
  Takahashi Katsunori、Kikuchi Haruhisa、Nguyen Van Hai、Oshima Yoshiteru、Ishigaki Hirotaka、Nakajima-Shimada Junko、Kubohara Yuzuru
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 40 Issue: 11 Pages: 1941-1947
- DOI
  10.1248/bpb.b17-00484
- NAID
  130006191965
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07964
[Journal Article] 微生物の可能性を開拓する-多様な新奇化合物合成のための新しいアプローチ-2016
- Author(s)
  浅井禎吾，大島吉輝
- Journal Title
  
  現代化学「解説」
  
  Volume: 9 Pages: 21-26
- Data Source
  KAKENHI-PROJECT-16H05346
[Journal Article] Glutathione S-transferase 4 is a putative DIF-binding protein that regulates the size of fruiting bodies in Dictyostelium discoideum.2016
- Author(s)
  Kuwayama H, Kikuchi H, Oshima Y, & Kubohara Y.
- Journal Title
  
  Biochem. Biophys. Rep.
  
  Volume: 8 Pages: 219-226
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K07964
[Journal Article] エピジェネティック制御を利用する新規医薬資源の開拓2016
- Author(s)
  浅井禎吾，大島吉輝
- Journal Title
  
  生化学「みにれびゅー」
  
  Volume: 88 Pages: 643-648
- NAID
  40020998625
- Data Source
  KAKENHI-PROJECT-16H05346
[Journal Article] A Derivative of Differentiation-Inducing Factor-3 Inhibits PAK1 Activity and Breast Cancer Cell Proliferation.2015
- Author(s)
  Oladimeji P, Kubohara Y, Kikuchi H, Oshima Y, Rusch C, Skerl R, & Diakonova M.
- Journal Title
  
  Int. J. Cancer Clinic. Res.
  
  Volume: 2 Pages: 3-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24590110
[Journal Article] A Derivative of Differentiation-Inducing Factor-3 Inhibits PAK1 Activity and Breast Cancer Cell Proliferation.2015
- Author(s)
  Oladimeji P, Kubohara Y, Kikuchi H, Oshima Y, Rusch C, Skerl R, & Diakonova M.
- Journal Title
  
  Int. J. Cancer Clinic. Res.
  
  Volume: 2 Pages: 3-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07964
[Journal Article] Development of novel DIF-1 derivatives that selectively suppress innate immune responses.2015
- Author(s)
  Nguyen VH, Kikuchi H, Kubohara Y, Takahashi K, Katou Y, & Oshima Y.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 23 Issue: 15 Pages: 4311-4315
- DOI
  10.1016/j.bmc.2015.06.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07964, KAKENHI-PROJECT-24590110
[Journal Article] Use of a Biosynthetic Intermediate to Explore the Chemical Diversity of Pseudo-natural Fungal Polyketides2015
- Author(s)
  T. Asai*, K. Tsukada, S. Ise, N. Shirata, M. Hashimoto, I. Fujii, K. Gomi, K. Nakagawara, E. N. Kodama, Y, Oshima
- Journal Title
  
  Nature Chem.
  
  Volume: 7 Issue: 9 Pages: 737-743
- DOI
  10.1038/nchem.2308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460117, KAKENHI-PROJECT-25670255, KAKENHI-PROJECT-25293022
[Journal Article] Derivatives of Dictyostelium differentiation-inducing factors inhibit lysophosphatidic acid–stimulated migration of murine osteosarcoma LM8 cells.2015
- Author(s)
  Kubohara Y, Komachi M, Homma Y, Kikuchi H, & Oshima Y.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 463 Issue: 4 Pages: 800-805
- DOI
  10.1016/j.bbrc.2015.06.016
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07964, KAKENHI-PROJECT-24590110
[Journal Article] Development of Diversity-enhanced Extracts of Curcuma zedoaria and Their Unprecedented Sesquiterpene-like Compounds2014
- Author(s)
  Oshima Y (3/3)
- Journal Title
  
  Org Lett
  
  Volume: 16 Pages: 1916-1919
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590666
[Journal Article] Properties of a non-bioactive fluorescent derivative of differentiation-inducing factor-3, an anti-tumor agent found in Dictyostelium discoideum.2014
- Author(s)
  Kubohara Y, Kikuchi H, Matsuo Y, Oshima Y, & Homma Y.
- Journal Title
  
  Biology Open
  
  Volume: 3 Issue: 4 Pages: 289-296
- DOI
  10.1242/bio.20146585
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590110, KAKENHI-PROJECT-15K07964
[Journal Article] 多様性拡大抽出物を利用した天然化合物ライブラリーの構築2014
- Author(s)
  大島吉輝 (2/2)
- Journal Title
  
  MEDCHEM NEWS, (日本薬学会医薬化学部会発行)
  
  Volume: 24(2) Pages: 45-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590666
[Journal Article] Structures of Spiroindicumides A and B, Unprecedented Carbon Skeletal Spirolactones, and Determination of the Absolute Configuration by Vibrational Circular Dichroism Exciton Approach.2013
- Author(s)
  Teigo Asai, Tohru Taniguchi, Takashi Yamamoto, Kenji Monde, Yoshiteru Oshima
- Journal Title
  
  Org. Lett.
  
  Volume: 15 Issue: 17 Pages: 4320-4323
- DOI
  10.1021/ol401741z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710244, KAKENHI-PROJECT-24310151, KAKENHI-PUBLICLY-25108702, KAKENHI-PROJECT-25293022
[Journal Article] 糸状菌二次代謝のエピジェネティック制御と天然物探索2013
- Author(s)
  浅井禎吾、大島吉輝
- Journal Title
  
  化学と生物
  
  Volume: 51 Pages: 13-21
- NAID
  10031146870
- Data Source
  KAKENHI-PROJECT-24590310
[Journal Article] An epigenetic modifier enhances the production of anti-diabetic and anti-inflammatory sesquiterpenoids from Aspergillus sydowii2013
- Author(s)
  Y. M. Chung, C. K. Wei, D. W. Chuang, M. E. Shazly, C. T. Hsieh, T. Asai, Y. Oshima, T. J. Hsieh, T. L. Hwang, Y. C. Wu, F. R. Chang
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 21 Issue: 13 Pages: 3866-3872
- DOI
  10.1016/j.bmc.2013.04.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710248, KAKENHI-PUBLICLY-25108702, KAKENHI-PROJECT-25293022
[Journal Article] Structures and absolute configurations of short-branched fatty acid dimers from an endophytic fungus of Aloe arborescens2013
- Author(s)
  Teigo Asai, Sae Otsuki, Tohru Taniguchi, Kenji Monde, Kouwa Yamashita, Hiroaki Sakurai, Tomoji Ozeki and Yoshiteru Oshima
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 54 Pages: 3402-3405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293022
[Journal Article] Suberoylanilide Hydroxamic Acid, a Histone Deacetylase Inhibitor, Induces the Production of Anti-inflammatory Cyclodepsipeptides from Beauveria felina2013
- Author(s)
  Y. M. Chung, M. E. Shazly, D. W. Chuang, T. L. Hwang, T. Asai, Y. Oshima, M. L. Ashour, Y. C. Wu, F. R. Chang
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 76 Issue: 7 Pages: 1260-1266
- DOI
  10.1021/np400143j
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25108702, KAKENHI-PROJECT-25293022
[Journal Article] Derivatives of Dictyostelium discoideum differentiation-inducing factor-3 suppress the activities of Trypanosoma cruzi in vitro and in vivo2013
- Author(s)
  Nakajima-Shimada J, Hatabu T, Hosoi Y, Onizuka Y, Kikuchi H, Oshima Y, & Kubohara Y
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590110
[Journal Article] Chlorinated Dibenzofurans Isolated from the Cellular Slime Mold, Polysphondylium filamentosum, and Their Biological Activities2013
- Author(s)
  Kikuchi, H.; Kubohara, Y.; Nguyen, V. H.; Katou, Y.; Oshima, Y. Novel
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: (In press) Issue: 15 Pages: 4628-4633
- DOI
  10.1016/j.bmc.2013.05.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710247, KAKENHI-PROJECT-24590110
[Journal Article] 糸状菌二次代謝のエピジェネティック制御と天然物探索(解説)2013
- Author(s)
  浅井禎吾、大島吉輝
- Journal Title
  
  化学と生物(日本農芸化学会編集・発行,国際文献社刊行)
  
  Volume: Vol.51,No.1 Pages: 13-21
- Data Source
  KAKENHI-PROJECT-23651212
[Journal Article] Benzophenones from an Endophytic Fungus, Graphiopsis chlorocephala, from Paeonia lactiflora Cultivated in the Presence of an NAD+-Dependent HDAC Inhibitor2013
- Author(s)
  T. Asai, S. Otsuki, H. Sakurai, K.Yamashita, T. Ozeki, Y. Oshima
- Journal Title
  
  Org.Lett
  
  Volume: 15 Issue: 8 Pages: 2058-2061
- DOI
  10.1021/ol400781b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22550056, KAKENHI-PROJECT-23710248, KAKENHI-PROJECT-25293022
[Journal Article] The Dictyostelium prestalk inducer DIF-1 directs phosphorylation of a bZIP transcription factor.2013
- Author(s)
  Yamada Y, Kubohara Y, Kikuchi H, Oshima Y, Wang HY, Ross S, & Williams JG.
- Journal Title
  
  Intenational Journal of Developmental Biology
  
  Volume: 57 Issue: 5 Pages: 375-381
- DOI
  10.1387/ijdb.130046jw
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590110
[Journal Article] Structurally Diverse Chaetophenol Productions Induced by Chemically Mediated Epigenetic Manipulation of Fungal Gene Expression2013
- Author(s)
  T. Asai, T. Yamamoto, N. Shirata, T. Taniguchi, K. Monde, I. Fujii, K. Gomi, Y. Oshima
- Journal Title
  
  Org. Lett.
  
  Volume: 15 Issue: 13 Pages: 3346-3349
- DOI
  10.1021/ol401386w
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22108007, KAKENHI-PROJECT-24310151, KAKENHI-PUBLICLY-25108702, KAKENHI-PUBLICLY-25108722, KAKENHI-PROJECT-25293022
[Journal Article] Mitochondria are the target organelle of differentiation-inducing factor-3, an anti-tumor agent isolated from Dictyostelium discoideum.2013
- Author(s)
  Kubohara Y, Kikuchi H, Matsuo Y, Oshima Y, & Homma Y.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 8 Pages: e72118-e72118
- DOI
  10.1371/journal.pone.0072118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590110
[Journal Article] ケミカルエピジェネティクスによる未利用生合成遺伝子の活用と多様な天然物の創出2013
- Author(s)
  浅井禎吾, 大島吉輝
- Journal Title
  
  ファルマシア
  
  Volume: 50 Pages: 112-116
- NAID
  130005143935
- Data Source
  KAKENHI-PROJECT-25293022
[Journal Article] Structures and biomimetic synthesis of a Novel α-pyrone polyketide of an endophytic Penicillium sp2013
- Author(s)
  T, Asai, D. Luo, K. Yamashita, Y. Oshima
- Journal Title
  
  Catharanthus roseus, Org. Lett
  
  Volume: 15 Issue: 5 Pages: 1021-1023
- DOI
  10.1021/ol303506t
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590041, KAKENHI-PROJECT-23651212, KAKENHI-PROJECT-23710248, KAKENHI-PROJECT-24590310
[Journal Article] Phenolic Compounds and Terpenoids from Hypericum lanceolatum2012
- Author(s)
  Oshima Y (9/9)
- Journal Title
  
  Rec Nat Prod
  
  Volume: 6 Pages: 94-100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590666
[Journal Article] Br-DIF-1 accelerates dimethyl sulphoxide-induced differentiation of P19CL6 embryonic carcinoma cells into cardiomyocytes2012
- Author(s)
  Seya K, Kanemaru K, Matsuki M, Hongo K, Kitahara H, Kikuchi H, Oshima Y, Kubohara Y, Okumura K, Motomura S, Furukawa K
- Journal Title
  
  Brit. J. Pharmacol
  
  Volume: 165(4) Pages: 870-879
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Stigmastane Derivatives from the Roots of Vernonia guineensis and Their Antimicrobial Activity2012
- Author(s)
  Oshima Y (9/9)
- Journal Title
  
  Phyto chemistry Lett
  
  Volume: 5 Pages: 596-599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590666
[Journal Article] Tenuipyrone, a Novel Skeletal Polyketide from the Entomopathogenic Fungus, Isaria tenuipes, Cultivated in the Presence of Epigenetic Modifiers2012
- Author(s)
  T. Asai, Y.-M. Chung, H. Sakurai, T. Ozeki, F.-R. Chang, K. Yamashita, Y. Oshima
- Journal Title
  
  Org.Lett.
  
  Volume: 14 Issue: 2 Pages: 513-515
- DOI
  10.1021/ol203097b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22550056, KAKENHI-PROJECT-23651212, KAKENHI-PROJECT-23710248, KAKENHI-PROJECT-24590310
[Journal Article] Br-DIF-1 accelerates dimethyl sulphoxide-induced differentiation of P19CL6 embryonic carcinoma cells into cardiomyocytes2012
- Author(s)
  Seya K, Kanemaru K, Matsuki M, Hongo K, Kitahara H, Kikuchi H, Oshima Y, Kubohara Y, Okumura K, Motomura S, Furukawa KI
- Journal Title
  
  British Journal of Pharmacology
  
  Volume: 165 Issue: 4 Pages: 870-879
- DOI
  10.1111/j.1476-5381.2011.01541.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090, KAKENHI-PROJECT-23591077
[Journal Article] Aromatic Polyketide Production in Cordyceps indigotica, an Entomopathogenic Fungus, Induced by Exposure to a Histone Deacetylase Inhibitor2012
- Author(s)
  Teigo Asai
- Journal Title
  
  Org. Lett.
  
  Volume: 14 Issue: 8 Pages: 2006-2009
- DOI
  10.1021/ol3005062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23651212
[Journal Article] Dihydrobenzofurans as Cannabinoid Receptor Ligands, from Cordyceps annullata, an Entomopathogenic Fungus, Cultivated in the Presence of HDAC Inhibitor2012
- Author(s)
  Teigo Asai, Dan Luo, Yutaro Obara, Toru Taniguchi, Kenji Monde, Kouwa Yamashita and Yoshiteru Oshima
- Journal Title
  
  Tetrahedron Lett
  
  Volume: 53 Issue: 17 Pages: 2239-2243
- DOI
  10.1016/j.tetlet.2012.02.088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23651212, KAKENHI-PROJECT-23710244, KAKENHI-PROJECT-23710248, KAKENHI-PROJECT-24310151
[Journal Article] Isolation, Synthesis and Biological Activity of Biphenyl and m-Terphenyl-Type Compounds from Dictyostelium Cellular Slime Molds2012
- Author(s)
  Kikuchi, H.; Matsuo, Y.; Katou, Y.; Kubohara, Y.; Oshima, Y
- Journal Title
  
  Tetrahedron
  
  Volume: 68 Issue: 43 Pages: 8884-8889
- DOI
  10.1016/j.tet.2012.08.041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710247, KAKENHI-PROJECT-24590110
[Journal Article] Aromatic Polyketide Glycosides from an Entomopathogenic Fungus, Cordyceps indigotica2012
- Author(s)
  Teigo Asai, Takashi Yamamoto, Yu-Ming Chung, Fang-Rong Chang, Yang-Chang Wu, Kouwa Yamashita and Yoshiteru Oshima
- Journal Title
  
  Tetrahedron Lett
  
  Volume: 53 Issue: 3 Pages: 277-280
- DOI
  10.1016/j.tetlet.2011.10.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23651212, KAKENHI-PROJECT-23710248
[Journal Article] Labdane-type Diterpenes and Flavones from Dodonaea viscose2012
- Author(s)
  Oshima Y (9/10)
- Journal Title
  
  Fitoterapia
  
  Volume: 83 Pages: 859-863
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590666
[Journal Article] Tenuipyrone, a Novel Skeletal Polyketide from the Entomopathogenic Fungus, Isaria tenuipes, Cultivated in the Presence of Epigenetic Modifiers2012
- Author(s)
  Teigo Asai, Yu-Ming Chung, Hiroaki Sakurai, Tomoji Ozeki, Fang-Rong Chang, Kouwa Yamashita and Yoshiteru Oshima
- Journal Title
  
  Org. Lett.
  
  Volume: 14 Pages: 513-515
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23651212
[Journal Article] Structures of the Dimeric and Monomeric Chromanones2012
- Author(s)
  Haruhisa Kikuchi, Masato Isobe, Shoichiro Kurata, Yasuhiro Katou and Yoshiteru Oshima
- Journal Title
  
  Gonytolides D . G, Isolated from the Fungus Gonytrichum sp., Tetrahedron
  
  Volume: (in press) Pages: 1-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21310134
[Journal Article] Structural Diversity of New C13 -Polyketides Produced by Chaetomium mollipilium Cultivated in the Presence of aNAD+-Dependent Histone DeacetylaseInhibitor2012
- Author(s)
  T. Asai, S. Morita, N. Shirata, T. Taniguchi, K. Monde, H. Sakurai, T. Ozeki, Y. Oshima
- Journal Title
  
  Org. Lett.
  
  Volume: 14 Issue: 21 Pages: 5456-5459
- DOI
  10.1021/ol302539s
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22550056, KAKENHI-PROJECT-23651212, KAKENHI-PROJECT-23710244, KAKENHI-PROJECT-23710248
[Journal Article] Highly oxidized ergosterols and isariotin analogs from an entomopathogenic fungus, Gibellula formosana, cultivated in the presence of epigenetic modifying agents2012
- Author(s)
  T. Asai, Y.-M. Chung, H. Sakurai, T. Ozeki,F.-R. Chang, Y.-C. Wu, K. Yamashita, Y. Oshima
- Journal Title
  
  Tetrahedron
  
  Volume: 68 Issue: 29 Pages: 5817-5823
- DOI
  10.1016/j.tet.2012.05.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22550056, KAKENHI-PROJECT-23651212, KAKENHI-PROJECT-23710248
[Journal Article] Derivatives of Dictyostelium differentiation-inducing factors promote mitogen-activated IL-2 production via AP-1 in Jurkat cells2011
- Author(s)
  Takahashi K, Murakami M, Kikuchi H, Oshima Y, Kubohara Y.
- Journal Title
  
  Life Sciences
  
  Volume: 88(11-12) Pages: 480-485
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Histone Deacetylase Inhibitor Induced the Production of Three Novel Prenylated Tryptophan Analogs in the Entomopathogenic Fungus, Torrubiella luteorostrata2011
- Author(s)
  Teigo Asai, Takashi Yamamoto and Yoshiteru Oshima
- Journal Title
  
  Tetrahedron Lett
  
  Volume: 52 Issue: 52 Pages: 7042-7045
- DOI
  10.1016/j.tetlet.2011.10.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23651212, KAKENHI-PROJECT-23710248
[Journal Article] Artificial compounds differentially control Dictyostelium chemotaxis and cell differentiation.2011
- Author(s)
  Kuwayama H, Kikuchi H, Oshima Y, Kubohara Y.
- Journal Title
  
  Cell Structure and Function
  
  Volume: 36 Pages: 21-26
- NAID
  130004137560
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Synthesis and Innate Immune Suppressive Effect of 1, 2-Cyclopentanediol Derivatives2011
- Author(s)
  Haruhisa Kikuchi, Kaori Okazaki, Mizuki Sekiya, Yasuyuki Uryu, Kazunori Ueda, Shoichiro Kurata, Yasuhiro Katou and Yoshiteru Oshima
- Journal Title
  
  Eur. J. Med. Chem
  
  Volume: 46 Pages: 1263-1273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21310134
[Journal Article] Atg1 allows second-signalled autophagic cell death in Dictyostelium2011
- Author(s)
  Luciani M-F, Giusti C, Harms B, Oshima Y, Kikuchi H, Kubohara Y, Golstein P
- Journal Title
  
  Autophagy
  
  Volume: 7(6) Pages: 501-508
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Structures of the Dimeric and Monomeric Chromanones, Gonytolides A-C, Isolated from the Fungus Gonytrichum sp.and Their Promoting Activities of Innate Immune Responses2011
- Author(s)
  Haruhisa Kikuchi, Masato Isobe, Mizuki Sekiya, Yuko Abe, Tsuyoshi Hoshikawa, Kazunori Ueda, Shoichiro Kurata, Yasuhiro Katou, Yoshiteru Oshima
- Journal Title
  
  Org.Lett.
  
  Volume: 13 Pages: 4624-4627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21310134
[Journal Article] Artificial compounds differentially control Dictyostelium chemotaxis and cell differentiation2011
- Author(s)
  Kuwayama H, Kikuchi H, Oshima Y, Kubohara Y
- Journal Title
  
  Cell Structure and Function
  
  Volume: 36(1) Pages: 21-26
- NAID
  130004137560
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Histone Deacetylase Inhibitor Induced the Production of Three Novel Prenylated Tryptophan Analogs in the Entomopathogenic Fungus, Torrubiella luteorostrata2011
- Author(s)
  Teigo Asai, Takashi Yamamoto and Yoshiteru Oshima
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 52 Pages: 7042-7045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23651212
[Journal Article] Structures of the Dimeric and Monomeric Chromanones, Gonytolides A . C2011
- Author(s)
  Haruhisa Kikuchi, Masato Isobe, Mizuki Sekiya, Yuko Abe, Tsuyoshi Hoshikawa, Kazunori Ueda, Shoichiro Kurata, Yasuhiro Katou and Yoshiteru Oshima
- Journal Title
  
  Isolated from the Fungus Gonytrichum sp. and Their Promoting Activities of Innate Immune Responses, Org. Lett.
  
  Volume: 13 Pages: 4624-4627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21310134
[Journal Article] A Phytoceramide Analog Stimulates the Production of Chemokines Through CREB Activation in Human Endothelial Cells2011
- Author(s)
  Mizuki Sekiya, Kazunori Ueda, Kaori Okazaki, Jun Terashima, Yasuhiro Katou, Haruhisa Kikuchi, Shoichiro Kurata and Yoshiteru Oshima
- Journal Title
  
  Int. Immunopharmacol.
  
  Volume: 11 Pages: 1497-1503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21310134
[Journal Article] Derivatives of Dictyostelium differentiation-inducing factors promote mitogen-activated IL-2 production via AP-1 in Jurkat cells.2011
- Author(s)
  Takahashi K, Murakami M, Kikuchi H, Oshima Y, Kubohara Y.
- Journal Title
  
  Life Sciences
  
  Volume: 88 Pages: 480-485
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] A Phytoceramide Analog Stimulates the Production of Chemokines Through CREB Activation in Human Endothelial Cells2011
- Author(s)
  Mizuki Sekiya, Kazunori Ueda, Kaori Okazaki, Jun Terashima, Yasuhiro Katou, Haruhisa Kikuchi, Shoichiro Kurata, Yoshiteru Oshima
- Journal Title
  
  Int.Immunopharmacol.
  
  Volume: 11 Pages: 1497-1503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21310134
[Journal Article] Preparation of an antibody that recognizes and neutralizes Dictyostelium differentiation-inducing factor-1. Biochem. Biophys2010
- Author(s)
  Kubohara Y, Kikuchi H, Nakamura K, Matsuo Y, Oshima Y
- Journal Title
  
  Res. Commun
  
  Volume: 396(2) Pages: 364-369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Novel prenylated and geranylated aromatic compounds isolated from Polysphondylium cellular slime molds.2010
- Author(s)
  Kikuchi H, Ishiko S, Nakamura K, Kubohara Y, Oshima Y.
- Journal Title
  
  Tetrahedron
  
  Volume: 66 Pages: 6000-6007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Novel prenylated and geranylated aromatic compounds isolated from Polysphondylium cellular slime molds2010
- Author(s)
  Kikuchi H, Ishiko S, Nakamura K, Kubohara Y, Oshima Y
- Journal Title
  
  Tetrahedron
  
  Volume: 66(32) Pages: 6000-6007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Preparation of an antibody that recognizes and neutralizes Dictyostelium differentiation-inducing factor-1.2010
- Author(s)
  Kubohara Y, Kikuchi H, Nakamura K, Matsuo Y, Oshima Y.
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 396 Pages: 364-369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] KSRP/FUBP2 is a Binding Protein of GO-Y086, a Cytotoxic Curcumin Analogue2010
- Author(s)
  Oshima Y (11/15)
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 1 Pages: 273-276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590666
[Journal Article] Synthesis and Innate Immune Suppressive Effect of 1,2-Cyclopentaned iol Derivatives2010
- Author(s)
  H.Kikuchi, K.Okazaki, M.Sekiya, Y.Uryu, K.Ueda, S.Kurata, Y.Katou, Y.Oshima
- Journal Title
  
  Eur.J.Med.Chem.
  
  Volume: (未定)(印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21310134
[Journal Article] Xanthones and a Benzophenone from the Roots of Pentadesma butyracea and Their Antiproliferative Activity2010
- Author(s)
  Oshima Y (5/5)
- Journal Title
  
  Phytochemistry Letters
  
  Volume: 3 Pages: 104-107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590666
[Journal Article] New Diterpene Pyrone-type Compounds, Metarhizins A and B, Isolated from Entomopathogenic Fungus, Metarhizium flavoviride and Their Inhibitory Effects on Cellular Proliferation2009
- Author(s)
  H. Kikuchi, T. Hoshi, M. Kitayama, M. Sekiya, Y. Katou, Y. Kubohara, K. Ueda, H. Sato, M. Shimazu, S. Kurata and Y. Oshima
- Journal Title
  
  Tetrahedron 65
  
  Pages: 469-477
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19310135
[Journal Article] Regulation of IL-2 production in Jurkat cells by Dictyostelium-derived factors.2009
- Author(s)
  Takahashi K, Murakami M, Hosaka K, Kikuchi H, Oshima Y, Kubohara Y.
- Journal Title
  
  Life Sciences 85
  
  Pages: 438-443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] New Diterpene Pyrone-type Compounds, Metarhizins A and B, Isolated from Entomopathogenic Fungus2009
- Author(s)
  Haruhisa Kikuchi, Tomoko Hoshi, Minoru Kitayama, Mizuki Sekiya, Yasuhiro Katou, Kazunori Ueda, Yuzuru Kubohara, Hiroki Sato, Mitsuaki Shimazu, Shoichiro Kurata, Yoshiteru Oshima
- Journal Title
  
  Metarhizium flavoviride and Their Inhibitory Effects on Cellular Proliferation, Tetrahedron 65
  
  Pages: 469-477
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19310135
[Journal Article] Autophagic or necrotic cell death triggered by distinct motifs of the differentiation factor DIF-1.2009
- Author(s)
  Luciani M-F, Kubohara Y, Kikuchi H, Oshima Y, Golstein P.
- Journal Title
  
  Cell Death & Differentiation 16
  
  Pages: 564-570
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Regulation of IL-2 production in Jurkat cells by Dictyostelium-derived factors2009
- Author(s)
  Takahashi K, Murakami M, Hosaka K, Kikuchi H, Oshima Y, Kubohara Y
- Journal Title
  
  Life Sciences
  
  Volume: 85(11-12) Pages: 438-443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Autophagic or necrotic cell death triggered by distinct motifs of the differentiation factor DIF-12009
- Author(s)
  Luciani M-F, Kubohara Y, Kikuchi H, Oshima Y, Golstein P
- Journal Title
  
  Cell Death & Differ
  
  Volume: 16(4) Pages: 264-570
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Revised Structure and Synthesis of Celastramycin A, a Potent Innate Immune Suppressor2009
- Author(s)
  Haruhisa Kikuchi, Mizuki Sekiya, Yasuhiro Katou, Kazunori Ueda, Takehiro Kabeya, Shoichiro Kurata, Yoshiteru Oshima
- Journal Title
  
  Org. Lett. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19310135
[Journal Article] Revised Structure and Synthesis of Celastramycin A, a Potent Innate Immune Suppressor2009
- Author(s)
  H. Kikuchi, M. Sekiya, Y. IKatou, K. Ueda, T. Kabeya, S. Kurata and Y. Oshima
- Journal Title
  
  Org. Lett. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19310135
[Journal Article] A Cyclopentanediol Analogue Selectively Suppresses the Conserved Innate Immunity Pathways, Drosophila IMD and TNF-α Pathways2008
- Author(s)
  Mizuki Sekiya, Kazunori Ueda, Kaori Okazaki, Haruhisa Kikuchi, Shoichiro Kurata, Yoshiteru Oshima
- Journal Title
  
  Biochem.Pharmacol. 75
  
  Pages: 2165-2174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19310135
[Journal Article] Establishment of ex vivo Systems to Identify Compounds Acting on Innate Immune Responses and to Determine Their Target Molecules Using Transgenic Drosophila2006
- Author(s)
  M.Sekiya, K.Ueda, T.Fujita, M.Kitayama, H.Kikuchi, Y.Oshima, S.Kurata
- Journal Title
  
  Life Science 80
  
  Pages: 113-119
- Data Source
  KAKENHI-PROJECT-18032013
[Journal Article] A cyclopentanediol analogue selectively suppress conserved innate immune pathways, the Drosophila IMD and TNF-a pathways
- Author(s)
  Sekiya, M., Ueda, K., Okazaki, K., Kikuchi, H., Kurata, S., Oshima, Y.
- Journal Title
  
  Biochemical Pharmacology (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18032013
[Journal Article] A cyclopentanediol analogue selectively suppress conserved innate immune pathways, the Drosophila IMD and TNF-a pathways
- Author(s)
  Sekiya, M., Ueda, K., Okazaki, K., Kikuchi, H., Kurata, S., Oshima, Y.
- Journal Title
  
  Biochemical Pharmacology (In prees)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19310135
[Patent] マラリア原虫の増殖抑制剤2019
- Inventor(s)
  美田敏宏、久保原禅、菊地晴久、大島吉輝
- Industrial Property Rights Holder
  順天堂大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-040682
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-15K07964
[Patent] アミド誘導体2014
- Inventor(s)
  菊地晴久、大島吉輝、服部俊夫、久保原禅、他
- Industrial Property Rights Holder
  東北大学、群馬大学、扶桑薬品工業株式会社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-038919
- Filing Date
  2014-02-21
- Data Source
  KAKENHI-PROJECT-24590110
[Patent] ジクチオピロン誘導体又はジヒドロジクチオピロン誘導体を有効成分とするオステオポンチン産生阻害剤2013
- Inventor(s)
  菊地晴久、大島吉輝、服部俊夫、久保原禅、他
- Industrial Property Rights Holder
  群馬大学、東北大学、扶桑薬品工業株式会社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-046197
- Filing Date
  2013-03-08
- Data Source
  KAKENHI-PROJECT-24590110
[Patent] 走化性運動制御剤2010
- Inventor(s)
  久保原禅, 岡島史和, 小町麻由美, 桑山秀一, 大島吉輝, 菊地晴久
- Industrial Property Rights Holder
  群馬大学
- Industrial Property Number
  2010-004319
- Filing Date
  2010-01-12
- Data Source
  KAKENHI-PROJECT-21590090
[Patent] 走化性運動制御剤2010
- Inventor(s)
  久保原禅、岡島史和、小町麻由美、桑山秀一、大島吉輝、菊地晴久
- Industrial Property Rights Holder
  久保原禅、桑山秀一、大島吉輝、菊地晴久
- Industrial Property Number
  2010-004319
- Filing Date
  2010-01-12
- Data Source
  KAKENHI-PROJECT-21590090
[Patent] インターロイキン-2産生抑制剤2009
- Inventor(s)
  久保原禅, 村上正巳, 高橋克典, 大島吉輝, 菊地晴久
- Industrial Property Rights Holder
  群馬大学、東北大学
- Industrial Property Number
  2009-112974
- Filing Date
  2009-05-07
- Data Source
  KAKENHI-PROJECT-21590090
[Patent] ピロール化合物を有効成分として含有するケモカイン産生阻害剤2009
- Inventor(s)
  倉田祥一朗, 菊地晴久, 加藤泰弘, 大島吉輝
- Industrial Property Rights Holder
  東北大学
- Filing Date
  2009-01-28
- Data Source
  KAKENHI-PROJECT-19310135
[Patent] インターロイキン-2産生抑制剤2009
- Inventor(s)
  久保原禅、村上正巳、高橋克典、大島吉輝、菊地晴久
- Industrial Property Rights Holder
  群馬大学
- Industrial Property Number
  2009-112974
- Filing Date
  2009-05-07
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] 多様性拡大抽出物由来インドールアルカロイド化合物群を利用した免疫チェックポイント阻害剤の開発2018
- Author(s)
  鈴木佳英，一戸佳祐，山田修，喜田進也，村瀬新也，大島吉輝，菊地晴久
- Organizer
  日本生薬学会第65回年会
- Data Source
  KAKENHI-PROJECT-16H05093
[Presentation] 多様性拡大抽出物を利用した免疫チェックポイント阻害剤の探索2018
- Author(s)
  鈴木佳英，一戸佳祐，村瀬新也，喜田進也，山田修，菊地晴久，大島吉輝
- Organizer
  日本薬学会第138年会（金沢）
- Data Source
  KAKENHI-PROJECT-16H05093
[Presentation] 多様性拡大抽出物を用いたインドールアルカロイド様化合物ライブラリーの構築2018
- Author(s)
  鈴木佳英，一戸佳祐，大島吉輝，菊地晴久
- Organizer
  第57回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-16H05093
[Presentation] 多様性拡大抽出物を利用した構造多様な新規メロテルペノイド型化合物ライブラリーの創出2017
- Author(s)
  河合航輔，中城陽太，菊地晴久，大島吉輝
- Organizer
  第７回食品薬学シンポジウム
- Data Source
  KAKENHI-PROJECT-16H05346
[Presentation] 新規DIF-3誘導体、DIF-3(+3)とHex-DIF-3、の生物活性の検討2017
- Author(s)
  高橋克典、Nguyen Van Hai、菊地晴久、大島吉輝、嶋田淳子、久保原禅
- Organizer
  日本細胞性粘菌学会
- Data Source
  KAKENHI-PROJECT-15K07964
[Presentation] ゲノムマイニングと麹菌異種生産によるジョロウグモ内生糸状菌の新規ポリケタイド類の開拓2017
- Author(s)
  塚田健人, 伊藤史織, 網谷雄志, 大島吉輝, 浅井禎吾
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16H05346
[Presentation] サイトカイニンによるジョロウグモ内生糸状菌の二次代謝活性化2017
- Author(s)
  森下陽平，岡崎裕亮, 大島吉輝, 浅井禎吾
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16H05346
[Presentation] 植物ホルモンを用いる糸状菌休眠型二次代謝経路の活性化2017
- Author(s)
  森下陽平, 岡崎裕亮, 羅伊伊, 萩原大祐, 高橋弘喜, 大島吉輝, 浅井禎吾
- Organizer
  第17回糸状菌分子生物学コンファレンス,
- Data Source
  KAKENHI-PROJECT-16H05346
[Presentation] DIF-1とその誘導体が有する抗菌活性の研究2017
- Author(s)
  久保原禅、佐々木啓、菊地晴久、大島吉輝
- Organizer
  日本細胞性粘菌学会
- Data Source
  KAKENHI-PROJECT-15K07964
[Presentation] Humulene の構造を基盤とした構造多様性指向型テルペノイドアルカロイド様化合物ライブラリーの構築2017
- Author(s)
  西村壮央，菊地晴久，權垠相，川井絢矢，大島吉輝
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16H05346
[Presentation] 多様性拡大植物抽出物を利用したケミカルライブラリーの拡充2016
- Author(s)
  大島吉輝
- Organizer
  第21回天然薬物の開発と応用シンポジウム
- Place of Presentation
  千葉大学薬学部（千葉市）
- Year and Date
  2016-10-27
- Invited
- Data Source
  KAKENHI-PROJECT-16H05093
[Presentation] 標的分子との結合状態に基づく抗マラリア物質 febrifugine 誘導体の合成2016
- Author(s)
  今重智貴, 菊地晴久, 大島吉輝
- Organizer
  第21回天然薬物の開発と応用シンポジウム
- Place of Presentation
  千葉大学薬学部（千葉市）
- Year and Date
  2016-10-27
- Data Source
  KAKENHI-PROJECT-16H05093
[Presentation] 薬用植物の多様性拡大抽出物を利用したビアリール型化合物ライブラリーの創出2016
- Author(s)
  榎大介, 中城陽太, 菊地晴久, 大島吉輝
- Organizer
  第21回天然薬物の開発と応用シンポジウム
- Place of Presentation
  千葉大学薬学部（千葉市）
- Year and Date
  2016-10-27
- Data Source
  KAKENHI-PROJECT-16H05093
[Presentation] DIF-1の機能とミトコンドリアの関係2016
- Author(s)
  久保原禅、菊地晴久、Nguyen Van Hai、桑山秀一、大島吉輝
- Organizer
  日本細胞性粘菌学会
- Place of Presentation
  上智大学（東京都千代田区）
- Data Source
  KAKENHI-PROJECT-15K07964
[Presentation] ジョロウグモ内生糸状菌のポストゲノム型天然物探索2016
- Author(s)
  浅井禎吾，塚田健人，森下陽平，伊藤史織，網谷雄志，岡崎裕亮，児玉栄一，大島吉輝
- Organizer
  第58回天然物有機化合物討論会
- Place of Presentation
  仙台
- Year and Date
  2016-09-14
- Data Source
  KAKENHI-PROJECT-16H05346
[Presentation] リボソーム標的薬剤耐性糸状菌が生産する休眠型二次代謝物の探索2015
- Author(s)
  山本崇史、森下陽平、網谷雄志、塚田健人、浅井禎吾、大島吉輝
- Organizer
  第57回天然有機化合物討論会
- Place of Presentation
  横浜
- Year and Date
  2015-09-09
- Data Source
  KAKENHI-PROJECT-15K14967
[Presentation] 天然物化学の再興を目指して：ケミカルエピジェネティクスと天然物の創出2015
- Author(s)
  大島吉輝
- Organizer
  創薬懇話会2015 in 徳島
- Place of Presentation
  鳴門
- Year and Date
  2015-07-02
- Invited
- Data Source
  KAKENHI-PROJECT-25293022
[Presentation] １型糖尿病モデルラットの血糖値に対するDIF-1（経口投与）の効果2015
- Author(s)
  河原田律子、中村彰男、高橋克典、菊地晴久、大島吉輝、久保原禅
- Organizer
  日本細胞性粘菌学会
- Place of Presentation
  弘前大学（青森県弘前市）
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-15K07964
[Presentation] １型糖尿病モデルラットの血糖値に対するDIF-1（経口投与）の効果2015
- Author(s)
  河原田律子、中村彰男、高橋克典、菊地晴久、大島吉輝、久保原禅
- Organizer
  日本細胞性粘菌学会第5回例会
- Place of Presentation
  弘前大学（青森県弘前市）
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-24590110
[Presentation] 糸状菌の単純芳香族ポリケタイドから複雑な二量化ポリケタイドの創生2014
- Author(s)
  塚田健人，浅井禎吾，白田直樹，藤井勲，五味勝也，大島吉輝
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25293022
[Presentation] Glutathione S-transferase 4 (GST4) is a putative binding protein for DIFs that regulate the size of fruiting bodies in D. discoideum2014
- Author(s)
  久保原禅、菊地晴久、大島吉輝、桑山秀一
- Organizer
  日本細胞性粘菌学会第４回例会
- Place of Presentation
  東北大学（仙台）
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-24590110
[Presentation] 細胞性粘菌由来化合物DIF-1誘導体の自然免疫抑制作用とその構造活性相関2014
- Author(s)
  Van Hai Nguyen、菊地晴久、久保原禅、大島吉輝
- Organizer
  日本細胞性粘菌学会第４回例会
- Place of Presentation
  東北大学（仙台）
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-24590110
[Presentation] Chaetophenol 類の生合成とエピジェネティック制御に関する研究2014
- Author(s)
  浅井禎吾，白田直樹，森田峻太郎，塚田健人，藤井勲，五味勝也，大島吉輝
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25293022
[Presentation] エピジェネティックな二次代謝活性化法を利用するイチイ内生糸状菌からの新規生物活性物質の探索2014
- Author(s)
  布木純，浅井禎吾，山下幸和，河治久実，児玉栄一，大島吉輝
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25293022
[Presentation] ツツジ科植物内生糸状菌を資源とした新規天然物の探索2014
- Author(s)
  大槻紗恵，浅井禎吾，山下幸和，大島吉輝
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25293022
[Presentation] 糸状菌二次代謝を活性化するNAD+依存型HDAC阻害剤の探索とそれを用いた新規天然物の創出2013
- Author(s)
  森田峻太郎,浅井禎吾,谷口透,門出健次,櫻井博章,尾関智二,山下幸和,大島吉輝
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23651212
[Presentation] HDAC阻害剤を用いた多様な糸状菌ポリケチド類の創出2013
- Author(s)
  山本崇史，浅井禎吾，谷口透，門出健次，山下幸和，大島吉輝
- Organizer
  日本薬学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24590310
[Presentation] HDAC阻害剤を用いた多様な糸状菌ポリケチド類の創出_Chetomium indicum由来スピロラクトン型新規ポリケチド類の単離構造決定2013
- Author(s)
  山本崇史,浅井禎吾,谷口透,門出健次,山下幸和,大島吉輝
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23651212
[Presentation] HDAC阻害剤を用いた昆虫寄生糸状菌Cordyceps indigoticaおよび植物内生糸状菌Chaetomium indicum由来新規芳香属ポリケチドの創出2012
- Author(s)
  山本崇史,浅井禎吾,山下幸和,大島吉輝
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23651212
[Presentation] 未利用遺伝子のエピジェネティックな発現制御を介した糸状菌二次代謝物の創生2012
- Author(s)
  大島吉輝、浅井禎吾
- Organizer
  日本薬学会第 132 年会(招待講演)
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23651212
[Presentation] Br-DIF-1による胚性癌腫細胞(P19CL6)の1%DMSOによる拍動心筋様細胞への分化促進におけるT型カルシウムチャネルの役割2012
- Author(s)
  瀬谷和彦, 金丸幸太, 松木瑞穂, 本郷恭子, 北原晴男, 菊地晴久, 大島吉輝, 久保原禅. 奥村謙, 元村成, 古川賢一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] NAD+依存型HDAC阻害剤を用いた新規ポリケチドの創出2012
- Author(s)
  森田峻太郎,浅井禎吾,山下幸和,大島吉輝
- Organizer
  第51回日本薬学会東北支部大会
- Place of Presentation
  青森
- Year and Date
  2012-10-07
- Data Source
  KAKENHI-PROJECT-23651212
[Presentation] Br-DIF-1による胚性癌腫細胞 (P19CL6) の1% DMSOによる拍動心筋様細胞への分化促進におけるT型カルシウムチャネルの役割2012
- Author(s)
  瀬谷和彦, 金丸幸太, 松木瑞穂, 本郷恭子, 北原晴男, 菊地晴久, 大島吉輝, 久保原禅, 奥村謙, 元村成, 古川賢一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] エピジェネティクスを制御する化学修飾酵素阻害剤を用いた多様な糸状菌ポリケチドの創生2012
- Author(s)
  浅井禎吾,山本崇史,森田峻太郎,白田直樹,大島吉輝
- Organizer
  第54回天然有機化合物討論会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23651212
[Presentation] 未利用遺伝子のエピジェネティックな発現制御を介する糸状菌二次代謝物の創生2012
- Author(s)
  大島吉輝
- Organizer
  日本薬学会第132年会シンポジウム(天然物化学の新しい潮流)
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-23651212
[Presentation] 未利用遺伝子のエピジェネティックな発現制御を介した糸状菌二次代謝物の創生2012
- Author(s)
  大島吉輝
- Organizer
  第36回理化学研究所「ケミカルバイオロジー研究領域」勉強会(招待講演)
- Place of Presentation
  和光
- Data Source
  KAKENHI-PROJECT-23651212
[Presentation] P19CL6胚性癌腫細胞の1%DMSOによる拍動心筋様細胞への分化誘導に及ぼすBr-DIF-1の作用2012
- Author(s)
  瀬谷和彦, 金丸幸太, 松木瑞穂, 本郷恭子, 北原晴男, 菊地晴久, 大島吉輝, 久保原禅. 奥村謙, 元村成, 古川賢一
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都
- Year and Date
  2012-03-16
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] 自然免疫増強物質gonytolide Aの誘導体合成と生物活性2012
- Author(s)
  星川毅、菊地晴久、阿部由布子、倉田祥一朗、加藤泰弘、大島吉輝
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-21310134
[Presentation] エピジェネティック制御を利用した新規有用物質の探索2012
- Author(s)
  浅井禎吾,Chung Yu-Ming,櫻井博章,尾関智二,山下幸和,大島吉輝
- Organizer
  昆虫寄生糸状菌Isaria tenuipes由来新規四環式ポリケチドtenuipyroneの単離構造決定,日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23651212
[Presentation] P19CL6胚性癌腫細胞の1% DMSOによる拍動心筋様細胞への分化誘導に及ぼすBr-DIF-1の作用2012
- Author(s)
  瀬谷和彦, 金丸幸太, 松木瑞穂, 本郷恭子, 北原晴男, 菊地晴久, 大島吉輝, 久保原禅, 奥村謙, 元村成, 古川賢一
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都
- Year and Date
  2012-03-16
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] Chaetomium indicumが生産する新規ポリケチドの生合成遺伝子の同定およびHDAC阻害剤を用いた発現制御に関する研究2012
- Author(s)
  白田直樹,浅井禎吾,大島吉輝
- Organizer
  第51回日本薬学会東北支部大会
- Place of Presentation
  青森
- Year and Date
  2012-10-07
- Data Source
  KAKENHI-PROJECT-23651212
[Presentation] 未利用遺伝子のエピジェネティックな発現制御を介する糸状菌二次代謝物の創生2012
- Author(s)
  大島吉輝
- Organizer
  第36回理化学研究所「ケミカルバイオロジー研究領域」勉強会
- Place of Presentation
  和光
- Year and Date
  2012-02-21
- Data Source
  KAKENHI-PROJECT-23651212
[Presentation] エピジェネティック制御を利用した新規有用物質の探索;昆虫寄生糸状菌Cordyceps annullataの生産する新規ジヒドロベンゾフラン類の構造とCB受容体アゴニスト活性2012
- Author(s)
  羅丹,浅井禎吾,山下幸和,大島吉輝
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23651212
[Presentation] エピジェネティクスを制御する化学修飾酵素阻害剤を用いた多様な糸状菌ポリケチドの創生2012
- Author(s)
  浅井禎吾，山本崇史，森田峻太郎，白田直樹，大島吉輝
- Organizer
  天然有機化合物討論会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590310
[Presentation] Br-DIF-1 accelerates 1% dimethyl sulfoxide-induced cardiomyocyte differentiation of P19CL6 embryonic carcinoma cells2011
- Author(s)
  Seya K, Kanemaru K, Matsuki M, Hongo K, Kitahara H, Kikuchi H, Oshima Y, Kubohara Y, Okumura K, Motomura S, Furukawa K-I
- Organizer
  The 28th Annual Meeting of ISHR Japanese Section
- Place of Presentation
  Tokyo
- Year and Date
  2011-12-03
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] Derivatives of Dictyostelium differentiation-inducing factors regulate mitogen-induced interleukin-2 production in Jurkat cells2011
- Author(s)
  久保原禅, 高橋克典, 村上正巳, 菊地晴久, 大島吉輝
- Organizer
  日本細胞生物学会第63回大会
- Place of Presentation
  札幌
- Year and Date
  2011-06-29
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] 天然資源由来の自然免疫応答制御物質の探索2011
- Author(s)
  藤村信平、菊地晴久、中村哲也、倉田祥一朗、加藤泰弘、大島吉輝
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-31
- Data Source
  KAKENHI-PROJECT-21310134
[Presentation] 自然免疫増強作用を有するgonytolide A誘導体の開発2011
- Author(s)
  星川毅、菊地晴久、阿部由布子、倉田祥一朗、加藤泰弘、大島吉輝
- Organizer
  第50回記念日本薬学会東北支部大会
- Place of Presentation
  仙台
- Year and Date
  2011-10-30
- Data Source
  KAKENHI-PROJECT-21310134
[Presentation] 低分子阻害剤を用いたエピジェネティック制御に基づく糸状菌由来新規二次代謝物の探索2011
- Author(s)
  浅井禎吾,山本崇史,鐘ユーミン,森田峻太郎,羅丹,山下幸和,大島吉輝
- Organizer
  第9回次世代を担う有機化学シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23651212
[Presentation] 環状デプシペプチド aspergillicin Eの自然免疫応答抑制作用とその合成研究2011
- Author(s)
  藤村信平、菊地晴久、中村哲也、倉田祥一朗、加藤泰弘、大島吉輝
- Organizer
  第50回記念日本薬学会東北支部大会
- Place of Presentation
  仙台
- Year and Date
  2011-10-30
- Data Source
  KAKENHI-PROJECT-21310134
[Presentation] HDAC阻害剤を利用した昆虫寄生糸状菌Cordyceps annullata由来新規ジヒドロベンゾフラン類の単離構造決定2011
- Author(s)
  羅丹,浅井禎吾,山下幸和,大島吉輝
- Organizer
  第50回日本薬学会東北支部大会
- Place of Presentation
  仙台
- Year and Date
  2011-10-30
- Data Source
  KAKENHI-PROJECT-23651212
[Presentation] Exploration of Innate Immune Regulators from Natural Resources2011
- Author(s)
  Haruhisa Kikuchi、 Mizuki Sekiya、 Yasuhiro Katou、 Shoichiro Kurata、 Yoshiteru Oshima
- Organizer
  AIMECS2011
- Place of Presentation
  東京
- Year and Date
  2011-11-30
- Data Source
  KAKENHI-PROJECT-21310134
[Presentation] Br-DIF-1 accelerates 1% dimethyl sulfoxide-induced cardiomyocyte differ entiation of P19CL6 embryonic carcinoma cells2011
- Author(s)
  Seya K, Kanemaru K, Matsuki M, Hongo K, Kitahara H, Kikuchi H, Oshima Y, Kubohara Y, Okumura K, Motomura S, Furukawa K-I
- Organizer
  The 28th Annual Meeting of ISHR Japanese Section
- Place of Presentation
  東京
- Year and Date
  2011-12-03
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] 糸状菌由来化合物gonytolide AのヒトTNF経路における作用の解析2011
- Author(s)
  阿部由布子、加藤泰弘、礒辺真人、関谷瑞樹、上田和則、菊地晴久、倉田祥一朗、大島吉輝
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-31
- Data Source
  KAKENHI-PROJECT-21310134
[Presentation] 昆虫を利用する天然物化学研究2011
- Author(s)
  大島吉輝
- Organizer
  日本薬学会第131年会(特別シンポジウム:天然物化学とケミカルバイオロジー)
- Place of Presentation
  静岡
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-21310134
[Presentation] 放線菌由来化合物celastramycin AのTNF経路に対する作用2011
- Author(s)
  加藤泰弘、関谷瑞樹、壁谷尚宏、上田和則、菊地晴久、倉田祥一朗、大島吉輝
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-31
- Data Source
  KAKENHI-PROJECT-21310134
[Presentation] エピジェネティックな酵素阻害剤を利用した昆虫寄生糸状菌Cordyceps indigotica由来新規芳香族ポリケチド類の単離構造決定2011
- Author(s)
  山本崇史,浅井禎吾,山下幸和,大島吉輝
- Organizer
  第50回日本薬学会東北支部大会
- Place of Presentation
  仙台
- Year and Date
  2011-10-30
- Data Source
  KAKENHI-PROJECT-23651212
[Presentation] エピジェネティックな遺伝子発現制御を利用した新規有用物質の創出2011
- Author(s)
  浅井禎吾,山本崇史,鐘ユーミン,森田峻太郎,羅丹,山下幸和,大島吉輝
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-23651212
[Presentation] エピジェネティック制御に基づく新規二次代謝物の創出2011
- Author(s)
  浅井禎吾,山本崇史,Chung Yu-Ming,羅丹,森田峻太郎,白田直樹,山下幸和,大島吉輝
- Organizer
  第53回天然有機化合物討論会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23651212
[Presentation] 自然免疫応答抑制作用を有するcelastramycin Aの構造活性相関2010
- Author(s)
  菊地晴久、壁谷尚宏、関谷瑞樹、上田和則、加藤泰弘、倉田祥一朗、大島吉輝
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21310134
[Presentation] 放線菌由来celastramycin Aを基盤とした自然免疫抑制剤の創製2010
- Author(s)
  壁谷尚宏、菊地晴久、加藤泰弘、関谷瑞樹、上田和則、倉田祥一朗、大島吉輝
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-21310134
[Presentation] 放線菌由来celastramycin Aを基盤とした自然免疫抑制剤の創製2010
- Author(s)
  壁谷尚宏、菊地晴久、加藤泰弘、関谷瑞樹、上田和則、倉田祥一朗、大島吉輝
- Organizer
  創薬懇話会2010
- Place of Presentation
  蔵王
- Year and Date
  2010-11-12
- Data Source
  KAKENHI-PROJECT-21310134
[Presentation] ショウジョウバエ自然免疫賦活化作用を有するgonytolide AのTNF経路に対する作用2010
- Author(s)
  阿部由布子、加藤泰弘、関谷瑞樹、礒辺真人、上田和則、菊地晴久、倉田祥一朗、大島吉輝
- Organizer
  第49回日本薬学会東北支部大会
- Place of Presentation
  郡山
- Year and Date
  2010-10-24
- Data Source
  KAKENHI-PROJECT-21310134
[Presentation] 新規生物資源の開拓ー昆虫寄生糸状菌と卵菌ー2010
- Author(s)
  菊地晴久, 佐藤雄一, 星朋子, 喜多山実, 関谷瑞樹, 礒辺真人, 三原健, 久保原禅, 佐藤大樹, 島津光明, 加藤泰弘, 倉田祥一朗, 大島吉輝
- Organizer
  第52回天然有機化合物討論会
- Place of Presentation
  静岡
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] Natural Products Regulating Innate Immunity2010
- Author(s)
  Yoshiteru Oshima
- Organizer
  International Symposium on AIDS and Tuberculosis
- Place of Presentation
  仙台
- Year and Date
  2010-01-13
- Data Source
  KAKENHI-PROJECT-21310134
[Presentation] 多機能分子DIFの受容体の探索2010
- Author(s)
  久保原禅, 桑山秀一, 菊地晴久, 大島吉輝
- Organizer
  第13回細胞性粘菌研究会
- Place of Presentation
  富山
- Year and Date
  2010-11-20
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] DIFアミド化誘導体による粘菌柄細胞分化と走化性運動の制御2010
- Author(s)
  久保原禅, 桑山秀一, 菊地晴久, 大島吉輝
- Organizer
  第13回細胞性粘菌研究会
- Place of Presentation
  富山
- Year and Date
  2010-11-20
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] Natural Products Regulating Innate Immunity2010
- Author(s)
  Yoshiteru Oshima
- Organizer
  The 7th International Symposium for Chinese Medicinal Chemists
- Place of Presentation
  高雄
- Year and Date
  2010-02-02
- Data Source
  KAKENHI-PROJECT-21310134
[Presentation] Natural Products Regulating Innate Immunity2010
- Author(s)
  Yoshiteru Oshima、Natural Products Regulating Innate Immunity
- Organizer
  International Seminar & Expo on Jamu
- Place of Presentation
  バンドン(インドネシア)
- Year and Date
  2010-11-05
- Data Source
  KAKENHI-PROJECT-21310134
[Presentation] 天然資源からの自然免疫制御物質の探索2010
- Author(s)
  菊地晴久、中村哲也、加藤泰弘、上田和則、関谷瑞樹、倉田祥一朗、大島吉輝
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21310134
[Presentation] 天然資源からの自然免疫制御物質の探索2009
- Author(s)
  菊地晴久、関谷瑞樹、礒辺真人、壁谷尚宏、中村哲也、上田和則、加藤泰弘、倉田祥一朗、大島吉輝
- Organizer
  第51回天然有機化合物討論会
- Place of Presentation
  名古屋
- Year and Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-21310134
[Presentation] Induction of autophagy in mouse fibloblast NIH3T3 cells by DIF-1, a stalk cell differentiation inducing factor of the cellular slime mould Dictyostelium discoideum and its derivatives (DIFs)2009
- Author(s)
  根津亜季子, 久保原禅, 菊地晴久, 大島吉輝, 山本章嗣
- Organizer
  第61回日本細胞生物学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] Jurkat T細胞におけるInterleukin-2産生に対するDIF誘導体の効果2009
- Author(s)
  久保原禅, 高橋克典, 村上正巳, 菊地晴久, 大島吉輝
- Organizer
  第12回細胞性粘菌研究会
- Place of Presentation
  山口
- Year and Date
  2009-10-10
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] 自然免疫応答抑制作用を有する celastramycin Aの合成および構造活性相関2009
- Author(s)
  菊地晴久、壁谷尚宏、関谷瑞樹、上田和則、加藤泰弘、倉田祥一朗、大島吉輝
- Organizer
  創薬懇話会2009
- Place of Presentation
  岐阜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-21310134
[Presentation] 自然免疫活性化作用を有する糸状菌由来成分の構造と合成研究2009
- Author(s)
  菊地晴久, 礒辺真人, 関谷瑞樹, 上田和則, 加藤泰弘, 倉田祥一朗, 大島吉輝
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-19310135
[Presentation] 自然免疫応答抑制作用を有する celastramycin Aの合成および構造活性相関2009
- Author(s)
  菊地晴久、壁谷尚宏、関谷瑞樹、上田和則、加藤泰弘、倉田祥一朗、大島吉輝
- Organizer
  第48回日本薬学会東北支部大会
- Place of Presentation
  仙台
- Year and Date
  2009-10-18
- Data Source
  KAKENHI-PROJECT-21310134
[Presentation] Jurkat T細胞におけるInterleukin-2産生に対するDIF誘導体の効果2009
- Author(s)
  久保原禅、高橋克典、村上正巳、菊地晴久、大島吉輝
- Organizer
  第12回細胞性粘菌研究会
- Place of Presentation
  山口大学(山口市)
- Year and Date
  2009-10-10
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] インドネシア由来微生物より得られた新規二次代謝産物2008
- Author(s)
  菊地晴久, 有泉加奈子, 関谷瑞樹, 上田和則, 倉田祥一朗, Haska Nadirman, 大島吉輝
- Organizer
  第47回日本薬学会東北支部大会
- Place of Presentation
  盛岡
- Year and Date
  2008-10-26
- Data Source
  KAKENHI-PROJECT-19310135
[Presentation] Exploration of New Immune Regulators from Natural Resources2008
- Author(s)
  Haruhisa Kikuchi, Mizuki Sekiya, Kaori Okazaki, Kazunori Ueda, Yasuhiro Katou, Shoichiro Kurata, Yoshiteru Oshima
- Organizer
  THE 20TH FRENCH-JAPANESE SYMPOSIUM ON MEDICINAL AND FINE CHEMISTRY
- Place of Presentation
  フランス・ボルドー
- Year and Date
  2008-09-08
- Data Source
  KAKENHI-PROJECT-19310135
[Presentation] インドネシア産微生物における新規二次代謝産物の探索2008
- Author(s)
  菊地晴久, 有泉加奈子, 関谷瑞樹, 上田和則, 倉田祥一朗, Haska Nadirman, 大島吉輝
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-19310135
[Presentation] 昆虫機能を利用した自然免疫制御物質の探索と創薬への展開2007
- Author(s)
  菊地晴久, 関谷瑞樹, 岡崎香織, 上田和則, 倉田祥一朗, 大島吉輝
- Organizer
  第49回天然有機化合物討論会
- Place of Presentation
  札幌
- Year and Date
  2007-09-19
- Data Source
  KAKENHI-PROJECT-19310135
[Presentation] 細胞性粘菌由来の薬理活性物質によるインターロイキン-2(IL-2)発現制御
- Author(s)
  高橋克典，村上正巳，菊池晴久，大島吉輝，久保原禅
- Organizer
  第59回日本臨床検査医学学術集会
- Place of Presentation
  京都国際会館
- Invited
- Data Source
  KAKENHI-PROJECT-24590110
[Presentation] 南米シャーガス病の病原虫トリパノソーマに対するDIFの効果
- Author(s)
  嶋田淳子、細井友夏里、畑生俊光、菊地晴久、大島吉輝、久保原禅
- Organizer
  日本細胞性粘菌学会
- Place of Presentation
  京都大学
- Data Source
  KAKENHI-PROJECT-24590110
[Presentation] 生物活性の無いDIF-3蛍光体の特性
- Author(s)
  久保原禅、菊地晴久、松尾祐介、大島吉輝、本間好
- Organizer
  日本細胞性粘菌学会
- Place of Presentation
  京都大学
- Data Source
  KAKENHI-PROJECT-24590110
[Presentation] HeLa細胞におけるDIF蛍光体の局在と機能
- Author(s)
  久保原禅、菊地晴久、松尾祐介、大島吉輝、本間好
- Organizer
  日本細胞性粘菌学会第２回例会
- Place of Presentation
  東京大学
- Invited
- Data Source
  KAKENHI-PROJECT-24590110

1. KIKUCHI Haruhisa (90302166)

# of Collaborated Projects: 6 results

# of Collaborated Products: 38 results
2. KUBOHARA Yuzuru (00221937)

# of Collaborated Projects: 3 results

# of Collaborated Products: 48 results
3. KATOU Yasuhiro (50455797)

# of Collaborated Projects: 2 results

# of Collaborated Products: 28 results
4. KOJIMA Itaru (60143492)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. FURUKAWA Ken-Ichi (20165468)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. KURATA Shoichiro (90221944)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. TAKAYA Yoshiaki (80301034)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. ARAI Makoto (30222722)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KAJIWARA Kagemasa (00204397)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ISHII Noaki (60096196)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. HIOKI Chizuko (50393195)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. ARAI Katsuhiko (60439734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KIMURA Minoru (10146706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. ONO Atsushi (40400155)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. WADA Kanichiro (20431447)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SEYA Kazuhiko (40281919)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. MOTOMURA Shigeru (40091756)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. HATAKEYAMA Susumu (20143000)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. WATAYA Yusuke (90127598)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. Kodama Eiichi (50271151)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. 石橋正己 (90212927)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 小鹿一 (50152492)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 太田富久 (50108560)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 飯田彰 (40202816)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 貫名学 (20113970)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 浪越通夫 (30189196)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 野原稔弘 (30037600)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 高山廣光 (90171561)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 小林淳一 (90221241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 吉川雅之 (90116129)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 宮瀬敏男 (60112497)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 大坂一生 (90550244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 浅井禎吾 (60572310)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
34. TANIGUCHI Tohru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. YAMASHITA Kouwa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 尾関智二

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
37. 五味勝也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OSHIMA Yoshiteru 大島 吉輝

Research Projects

Research Products

Co-Researchers

多様性拡大抽出物を活用した薬理活性志向型天然化合物類縁体ライブラリーの構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Use of Fungal Strains Resistant to Ribosome Targeting-Antibiotics for Discovery of Cryptic Secondary MetabolitesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Discovery of Novel Natural Products from Fungi by Epigenetic Expression of Secondary Metabolite Biosynthetic GenesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Search for plant-origin natural products by epigenetics-modifying chemicalsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Search for novel natural products using chemical inhibitors modifying epigenticsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of Natural Product-Derived Innate Immune Regulators Using Insect Immune SystemsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Search for Natural Products Regulating Innate Immunity and Analysis of Their Mode of ActionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

天然物由来の自然免疫制御物質の創製Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

OSHIMA Yoshiteru 大島吉輝