AZUMA TOSHIFUMI 東俊文

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AZUMA Toshifumi 東俊文

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Researcher Number	00222612
Other IDs
Affiliation (based on the past Project Information) *help	2018 – 2023: 東京歯科大学, 歯学部, 教授 2012 – 2015: 東京歯科大学, 歯学部, 教授 2005 – 2006: 東京歯科大学, 歯学部, 助教授 2004: Keio University, School of Medicine, lecturer, 医学部, 講師 2002 – 2003: Keio University, School of Medicine, Assistant professor, 医学部, 専任講師 2001 – 2002: Keio University School of Medicine, Internal Medicine, Instructor, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 57060:Surgical dentistry-related / Gastroenterology / Gastroenterology / Functional basic dentistry Except Principal Investigator Basic Section 57060:Surgical dentistry-related / Gastroenterology / Gastroenterology / Basic Section 57010:Oral biological science-related / Medium-sized Section 57:Oral science and related fields / Basic Section 57030:Conservative dentistry-related / Biomedical engineering/Biological material science
Keywords	Principal Investigator 骨芽細胞 / iPS細胞 / 線維性骨異形成症 / GNAS / ヘッジホッグ / 骨代謝 / ゴーリン症候群 / シングルセル解析 / McCuneAlbright 症候群 / FGFG2 … More / 骨芽細胞分化誘導 / 遺伝性稀少疾患 / 線維化 / 骨異形成症 / Hedghog / 骨芽細胞分化 / 遺伝子編集 / 悪性腫瘍 / Gタンパク質 / McCune Albright Syndrome / GANS / ヘッジホッグ経路 / マキューンオルブライト症候群 / ｃAMP / 石灰化 / iPS / Hedgehog / cAMP / 骨粗しょう症治療薬 / Hedgehog経路 / McCuneAlbright症候群 / Gorlin症候群 / GPCR / 消化管腫瘍 / McCune Albright 症候群 / 骨 / Spleen / Primary hepatocyte culture / Hepatocyte transplantation / Liver cirrhosis / liver Failure / Stem cell transplantation / Stem Cell / SP cell / side population (SP)細胞 / 脾臓 / 初代培養肝細胞 / 肝細胞移植 / 肝硬変 / 肝不全 / 幹細胞移植 / 幹細胞 / side population(SP)細胞 / Rho GTPase / Metastasis / Cancer / 大腸癌 / 細胞運動 / Rac / Rho ファミリー蛋白質 / small G protein / RhoファミリーG蛋白 / 転移 / 癌 / 骨組織 / アルカリフォスファターゼ / 骨欠損モデル / 骨リモデリング / 骨再生 / Wnt / 骨細胞 / 疾患特異的iPS細胞 / 再生医療 … More Except Principal Investigator SP細胞 / 象牙芽細胞 / 破骨細胞分化 / Hadju-Cheney症候群 / 破骨細胞 / iPS細胞 / 肝不全 / 肝硬変 / 移植医療 / 細胞融合 / 肝再生 / 自家細胞移植 / 脾臓 / 大腸癌 / 幹細胞 / ShRNA / IGF / Rac1 / 細胞接着 / ドラッグデリバリー / リン代謝 / GNAS / Fibrous dysplasia / 線維性異形成症 / Notch / FGF23 / 線維性骨異形成症 / Cre/loxP遺伝情報改変技術 / 第三象牙質 / PTH受容体 / 歯髄細胞稠密層 / 象牙質 / PTH / 細胞の枯渇実験 / 細胞系譜解析 / 細胞稠密層 / 歯髄幹細胞 / 修復象牙質 / 骨髄造血 / 骨髄間葉系幹細胞 / レプチン受容体陽性細胞 / osteoprotegerin / 老化 / 間葉系細胞 / 骨 / レプチン受容体 / OPG / 骨格幹細胞 / 骨髄 / 骨芽細胞 / 副甲状腺ホルモン / 脂肪細胞 / 細胞膜センサータンパク質 / 細胞分化 / 再生医療 / Notch2 / Hadju-cheney症候群 / 骨芽細胞分化 / 遺伝子解析 / Hajdu-Cheney 症候群 / SiRNA / c-Met / columnar morphogenesis / C－MET / Cdx2 / 化学療法抵抗性大腸癌 / 細胞接着関連タンパクの破綻 / CDX2 / transdifferentiation / Splenic side population / Auto-stem cell transplantation / GFPトランスジェニックラット / 幹細胞移植 / 肝臓 / 分化転換 / 脾臓SP細胞 / 自己幹細胞移植 / hepatic differentiation induction method / collagen gel sandwich configuration / stem cell autotransplantation / side population cell / コラーゲンゲル / 初代培養肝細胞 / 肝細胞分化 / 肝細胞分化誘導法 / コラーゲンゲルサインドイッチ法 / 幹細胞自家移植療法 / GTP-bindinK protein / Rho-fatnily GTPases / Racl / metastasis / colon cancer / GTP結合タンパク質 / Rhoファミリー / 転移 / Microfabrication / Ito cell / Hepatocyte / Apoptosis / Stem cell / Matrix / Mixed culture / Artificial Liver Support / ステムセル / アルブミン / マイクロファブレケーション / マイクロファブリケーション / 細胞移植 / アポトーシス / マトリックス / 伊東細胞 / 肝細胞 / 人工肝 / EGF / 上皮間葉転換 / caveolin1 / ShRNA, SiRNA / 免疫染色 / ShRNA,siRNA / CDX2強制発現大腸癌株 / sp細胞 / c-MET / CDX2強制発現大腸癌細胞株 Less

Exploration of a treatment for Hajdu-Cheney syndrome by Drug Repositioning using disease-specific iPS cells.
- Principal Investigator
  
  間奈津子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Tokyo Dental College
Development of a new treatment for fibrodysplasia using active genomics and high-throughput analysisPrincipal Investigator
- Principal Investigator
  
  AZUMA TOSHIFUMI
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Tokyo Dental College
Induction of osteoclast differentiation of Hajdu Cheney Syndrome specific iPS cells.
- Principal Investigator
  
  Aida Natsuko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Tokyo Dental College
Identification of novel dental pulp stem cells and analysis of their regulatory mechanisms of differentiation
- Principal Investigator
  
  Mizoguchi Toshihide
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57010:Oral biological science-related
- Research Institution
  Tokyo Dental College
Comprehensive understanding of fibrous dysplasia of the jaw based on the mechanism of FGF23 production and abnormal phosphorus metabolism.
- Principal Investigator
  
  Yamaguchi Akira
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Tokyo Dental College
Establishment of Platform for Dentin Regeneration Drug Discovery by Targeting Multiple Signals that Regulate Odontoblast Function and Differentiation
- Principal Investigator
  
  Shibukawa Yoshiyuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Tokyo Dental College
Analysis fo osteoclast-regulated bone marrow aging and its application to rejuvenation of hematopoietic function
- Principal Investigator
  
  Toshihide Mizoguchi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Tokyo Dental College
Elucidation of osteoblast mineralization mechanism using McCunealbright syndrome iPS cellsPrincipal Investigator
- Principal Investigator
  
  AZUMA TOSHIFUMI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Tokyo Dental College
Basic research for development of osteoregeneration therapy using mesenchymal stem cells and iPS cellsPrincipal Investigator
- Principal Investigator
  
  Azuma TOSHIFUMI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Tokyo Dental College
The Mechanism of disintegration and redifferentiation of cell adhesion proteins through CDX2 in chemotherapy refractory colorectal cancer.
- Principal Investigator
  
  FUNAKOSHI SHINSUKE
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
The Association between CDX2 and tyrosine kinases in chemotherapy refractory colorectal cancer and its mechanism.
- Principal Investigator
  
  FUNAKOSHI Shinsuke
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
Basic Research for Regeneration Therapy for Liver FailurePrincipal Investigator
- Principal Investigator
  
  AZUMA Toshifumi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  TOKYO DENTAL COLLEGE
Splenic SP-cells offer the potential of autologous cell therapy aimed at liver regeneration.Principal Investigator
- Principal Investigator
  
  KATO Shinzo, 東俊文
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
Experimental research for treatment of liver failure with hepatic tissue stem cell (SP cell)
- Principal Investigator
  
  HORIE Yoshinori, 石井裕正
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
The essential role of Rho family G protein in tumor metastasis and invasion.Principal Investigator
- Principal Investigator
  
  AZUMA Toshifumi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
Regulation of the cancer cell motility by Racl GTPase: implications for metastasis of colon cancer
- Principal Investigator
  
  NAKANO Masaru
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  TOKYO DENTAL COLLEGE
Inventory of Artificial Liver Support based on the mixed culture system of Hepatocytes with Ito cells
- Principal Investigator
  
  ISHII Hiromasa
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Keio University

All 2023 2022 2021 2020 2019 2016 2015 2014 2013 2007 2006 Other

All Journal Article Presentation Book Patent

[Book] 期待されるチアゾリジン薬脂肪肝に対する作用2007
- Author(s)
  東俊文
- Total Pages
  225
- Publisher
  フジメディカル出版社
- Data Source
  KAKENHI-PROJECT-17590682
[Journal Article] Hedgehog-Related Mutation Causes Bone Malformations with or without Hereditary Gene Mutations2023
- Author(s)
  Onodera Shoko、Azuma Toshifumi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 16 Pages: 12903-12903
- DOI
  10.3390/ijms241612903
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K10103, KAKENHI-PROJECT-21H03146
[Journal Article] FGF-2 promotes proliferation and consequently induces osteoblast differentiation in mesenchymal stem cells.2023
- Author(s)
  Ogura H, Nakamura T, Ishii T, Saito A, Onodera S, Yamaguchi A, Nishii Y, Azuma T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 684 Pages: 684-684
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H03146
[Journal Article] Mechanical stress-induced FGF-2 promotes proliferation and consequently induces osteoblast differentiation in mesenchymal stem cells2023
- Author(s)
  Ogura H, Nakamura T, Ishii T, Saito A, Onodera S, Yamaguchi A, Nishii Y, Azuma T
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 684 Pages: 149145-149145
- DOI
  10.1016/j.bbrc.2023.149145
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03894
[Journal Article] Current Status of Next-Generation Sequencing in Bone Genetic Diseases2023
- Author(s)
  Aida Natsuko、Saito Akiko、Azuma Toshifumi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 18 Pages: 13802-13802
- DOI
  10.3390/ijms241813802
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K09342, KAKENHI-PROJECT-21H03146
[Journal Article] Runx2 regulates chromatin accessibility to direct the osteoblast program at neonatal stages2022
- Author(s)
  Hojo Hironori, Saito Taku, He Xinjun, Guo Qiuyu, Onodera Shoko, Azuma Toshifumi, Koebis Michinori, Nakao Kazuki, Aiba Atsu, Seki Masahide, Suzuki Yutaka, Okada Hiroyuki, Tanaka Sakae, Chung Ung-il, McMahon Andrew P., Ohba Shinsuke
- Journal Title
  
  Cell Reports
  
  Volume: 40 Issue: 10 Pages: 111315-111315
- DOI
  10.1016/j.celrep.2022.111315
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05318, KAKENHI-PROJECT-22K10212, KAKENHI-PROJECT-22K10261, KAKENHI-PROJECT-21K19552, KAKENHI-PROJECT-21K19589, KAKENHI-PROJECT-22KK0272, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-21H04952, KAKENHI-PROJECT-20H03885, KAKENHI-PROJECT-17K11932, KAKENHI-PROJECT-21K19883, KAKENHI-PROJECT-23K21494, KAKENHI-PROJECT-21H03146
[Journal Article] Progress and Current Status in Hajdu-Cheney Syndrome with Focus on Novel Genetic Research2022
- Author(s)
  Aida Natsuko、Ohno Tatsukuni、Azuma Toshifumi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 19 Pages: 11374-11374
- DOI
  10.3390/ijms231911374
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K10170, KAKENHI-PROJECT-21H03146
[Journal Article] Bone regeneration of induced pluripotent stem cells derived from peripheral blood cells in collagen sponge scaffolds2022
- Author(s)
  Kato Hiroshi、Watanabe Katsuhito、Saito Akiko、Onodera Shoko、Azuma Toshifumi、Takano Masayuki
- Journal Title
  
  Journal of Applied Oral Science
  
  Volume: 30
- DOI
  10.1590/1678-7757-2021-0491
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K19176, KAKENHI-PROJECT-21H03146
[Journal Article] Development of a targeted gene panel for the diagnosis of Gorlin syndrome2022
- Author(s)
  Nakamura Y.、Onodera S.、Takano M.、Katakura A.、Nomura T.、Azuma T.
- Journal Title
  
  International Journal of Oral and Maxillofacial Surgery
  
  Volume: 000 Issue: 11 Pages: 000-000
- DOI
  10.1016/j.ijom.2022.03.054
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H03146, KAKENHI-PROJECT-21K10103
[Journal Article] The effect of BMP4, FGF8 and WNT3a on mouse iPS cells differentiating to odontoblast-like cells.2022
- Author(s)
  Takada K, Odashima A, Onodera S, Saito A, Aida N, Furusawa M, Azuma T.
- Journal Title
  
  Med Mol Morphol.
  
  Volume: 55(3) Issue: 3 Pages: 199-209
- DOI
  10.1007/s00795-022-00318-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03146
[Journal Article] Effects of KnockOut Serum Replacement on Differentiation of Mouse-Induced Pluripotent Stem Cells into Odontoblasts2022
- Author(s)
  Furukawa Y, Odashima A, Hoshino T, Onodera S, Saito A, Ichinohe T, Azuma T.
- Journal Title
  
  Bull. Tokyo Dent. Coll.
  
  Volume: 63 Issue: 2 Pages: 75-83
- DOI
  10.2209/tdcpublication.2021-0042
- ISSN
  0040-8891
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03146
[Journal Article] Induced pluripotent stem cells from homozygous Runx2-deficient mice show poor response to vitamin D during osteoblastic differentiation2022
- Author(s)
  Aoki Hideto、Suzuki Eiichi、Nakamura Takashi、Onodera Shoko、Saito Akiko、Ohtaka Manami、Nakanishi Mahito、Nishimura Ken、Saito Atsushi、Azuma Toshifumi
- Journal Title
  
  Medical Molecular Morphology
  
  Volume: 000 Issue: 3 Pages: 000-000
- DOI
  10.1007/s00795-022-00317-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03146, KAKENHI-PROJECT-21K17027, KAKENHI-PROJECT-21K10103
[Journal Article] Novel alterations in IFT172 and KIFAP3 may induce basal cell carcinoma2021
- Author(s)
  Onodera Shoko、Morita Nana、Nakamura Yuriko、Takahashi Shinichi、Hashimoto Kazuhiko、Nomura Takeshi、Katakura Akira、Kosaki Kenjiro、Azuma Toshifumi
- Journal Title
  
  Orphanet Journal of Rare Diseases
  
  Volume: 16 Issue: 1 Pages: 000-000
- DOI
  10.1186/s13023-021-02033-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03833, KAKENHI-PROJECT-21H03146, KAKENHI-PROJECT-21K10103, KAKENHI-PROJECT-20K18710
[Journal Article] The Expression Levels of Vinculin in Pancreatic Cancer Tissues Significantly Correlates With Patient Survival2021
- Author(s)
  ISLAM SHAJEDUL、KITAGAWA TAKAO、AZUMA TOSHIFUMI、KURAMITSU YASUHIRO
- Journal Title
  
  Anticancer Research
  
  Volume: 41 Issue: 10 Pages: 4979-4984
- DOI
  10.21873/anticanres.15311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03833, KAKENHI-PROJECT-21H03146
[Journal Article] Mechanical stimulation-induced calcium signaling by Piezo1 channel activation in human odontoblast reduces dentin mineralization2021
- Author(s)
  Matsunaga Mayumi, Kimura Maki, Ouchi Takehito, Nakamura Takashi, Ohyama Sadao, Ando Masayuki, Nomura Sachie, Azuma Toshifumi, Ichinohe Tatsuya, Shibukawa Yoshiyuki
- Journal Title
  
  Frontiers in Physiology
  
  Volume: 12 Pages: 704518-704518
- DOI
  10.3389/fphys.2021.704518
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10117, KAKENHI-PROJECT-19H03833, KAKENHI-PROJECT-21H03146
[Journal Article] The concurrent stimulation of Wnt and FGF8 signaling induce differentiation of dental mesenchymal cells into odontoblast-like cells2021
- Author(s)
  Kimura Motoyoshi、Saito Akiko、Onodera Shoko、Nakamura Takashi、Suematsu Makoto、Shintani Seikou、Azuma Toshifumi
- Journal Title
  
  Medical Molecular Morphology
  
  Volume: 55 Issue: 1 Pages: 8-19
- DOI
  10.1007/s00795-021-00297-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03833, KAKENHI-PROJECT-21H03146, KAKENHI-PROJECT-21K10171, KAKENHI-PROJECT-19K19074
[Journal Article] Keratinocytes from Gorlin Syndrome-induced pluripotent stem cells are resistant against UV radiation2020
- Author(s)
  Morita Nana、Onodera Shoko、Nakamura Yuriko、Nakamura Takashi、Takahashi Shin-ichi、Nomura Takeshi、Azuma Toshifumi
- Journal Title
  
  Medical Molecular Morphology
  
  Volume: - Issue: 2 Pages: 795-795
- DOI
  10.1007/s00795-020-00264-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18710, KAKENHI-PROJECT-18K09753, KAKENHI-PROJECT-18H03007
[Journal Article] Tissue-nonspecific alkaline phosphatase promotes the osteogenic differentiation2020
- Author(s)
  Nakamura T, Nakamura-Takahashi A, Kasahara M, Yamaguchi A, Azuma T.
- Journal Title
  
  BERC
  
  Volume: 524(3) Issue: 3 Pages: 702-709
- DOI
  10.1016/j.bbrc.2020.01.136
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03007, KAKENHI-PROJECT-19H03833, KAKENHI-PROJECT-20H03894
[Journal Article] TSLP is a negative regulator of RANKL-induced osteoclastogenesis.2020
- Author(s)
  Ohno, T., Nakamura, T., Nakae, S., Morita, H., Matsumoto, K., Takeda, K., Okumura, K., and Azuma, T.
- Journal Title
  
  Biochem. Biophsy. Res. Commun.
  
  Volume: 530 Issue: 3 Pages: 508-512
- DOI
  10.1016/j.bbrc.2020.05.055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02695, KAKENHI-PROJECT-18H02847, KAKENHI-PROJECT-18H03007
[Journal Article] A novel GNAS-mutated human induced pluripotent stem cell model for understanding GNAS-mutated tumors.2020
- Author(s)
  Watanabe K, Nakamura T, Onodera S, Saito A, Shibahara T, Azuma T.
- Journal Title
  
  Tumour Biol.
  
  Volume: 42(9) Issue: 9 Pages: 1177-1177
- DOI
  10.1177/1010428320962588
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03007
[Journal Article] CAGE-seq analysis of osteoblast derived from cleidocranial dysplasia human induced pluripotent stem cells2020
- Author(s)
  Ooki Akio、Onodera Shoko、Saito Akiko、Oguchi Akiko、Murakawa Yasuhiro、Sakamoto Teruo、Sueishi Kenji、Nishii Yasushi、Azuma Toshifumi
- Journal Title
  
  Bone
  
  Volume: 141 Pages: 115582-115582
- DOI
  10.1016/j.bone.2020.115582
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21407, KAKENHI-PROJECT-20KK0186, KAKENHI-PROJECT-18H03992, KAKENHI-PROJECT-18H03007
[Journal Article] The effects of parathyroid hormone on osteoblastic differentiation of mouse induced pluripotent stem cells in a 3-D culture model.2020
- Author(s)
  Sato M, Aoki H, Nakamura T, Onodera S, Yamaguchi A, Saito A, Azuma T
- Journal Title
  
  J Period Res
  
  Volume: 55 Issue: 5 Pages: 734-743
- DOI
  10.1111/jre.12762
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03894, KAKENHI-PROJECT-18H03007
[Journal Article] Stepwise strategy for generating osteoblasts from human pluripotent stem cells under fully defined xeno-free conditions with small-molecule inducers2020
- Author(s)
  Zujur Denise、Kanke Kosuke、Onodera Shoko、Tani Shoichiro、Lai Jenny、Azuma Toshifumi、Xin Xiaonan、Lichtler Alexander C.、Rowe David W.、Saito Taku、Tanaka Sakae、Masaki Hideki、Nakauchi Hiromitsu、Chung Ung-il、Hojo Hironori、Ohba Shinsuke
- Journal Title
  
  Regenerative Therapy
  
  Volume: 14 Pages: 19-31
- DOI
  10.1016/j.reth.2019.12.010
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11932, KAKENHI-PROJECT-18K09055, KAKENHI-PROJECT-18K19635, KAKENHI-PROJECT-18K19636, KAKENHI-PROJECT-19K22677, KAKENHI-PROJECT-16H06312, KAKENHI-PROJECT-18H03007, KAKENHI-PROJECT-17H05106, KAKENHI-PROJECT-17K11898, KAKENHI-PROJECT-17H04403, KAKENHI-PROJECT-18H02998, KAKENHI-PROJECT-19H03833, KAKENHI-PROJECT-17K10955, KAKENHI-PROJECT-17K10997
[Journal Article] Hedgehog Activation Regulates Human Osteoblastogenesis2020
- Author(s)
  Onodera Shoko、Saito Akiko、Hojo Hironori、Nakamura Takashi、Zujur Denise、Watanabe Katsuhito、Morita Nana、Hasegawa Daigo、Masaki Hideki、Nakauchi Hiromitsu、Nomura Takeshi、Shibahara Takahiko、Yamaguchi Akira、Chung Ung-il、Azuma Toshifumi、Ohba Shinsuke
- Journal Title
  
  Stem Cell Reports
  
  Volume: 15 Issue: 1 Pages: 125-139
- DOI
  10.1016/j.stemcr.2020.05.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11932, KAKENHI-PROJECT-16H06312, KAKENHI-PROJECT-18H02998, KAKENHI-PROJECT-18K19636, KAKENHI-PROJECT-17H04403, KAKENHI-PROJECT-20H03885, KAKENHI-PROJECT-20H03894, KAKENHI-PROJECT-18H03007
[Journal Article] Gorlin Syndrome: Recent Advances in Genetic Testing and Molecular and Cellular Biological Research2020
- Author(s)
  Onodera Shoko、Nakamura Yuriko、Azuma Toshifumi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 20 Pages: 7559-7559
- DOI
  10.3390/ijms21207559
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09753, KAKENHI-PROJECT-18H03007
[Journal Article] Stage-dependent differential gene expression profiles of cranial neural2020
- Author(s)
  Odashima A, Onodera S, Saito A, Ogihara Y, Ichinohe T, Azuma T.
- Journal Title
  
  Med Mol　Morphology
  
  Volume: 53(1) Issue: 1 Pages: 28-41
- DOI
  10.1007/s00795-019-00229-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03007, KAKENHI-PROJECT-19K19247, KAKENHI-PROJECT-19H03833
[Journal Article] Transplantation of human induced pluripotent stem cells carried by self-assembling peptide nanofiber hydrogel improves bone regeneration in rat calvarial bone defects.2016
- Author(s)
  Kamichika Hayashi, Hiromi Ochiai-Shino, Takeaki Shiga, Shoko Onodera, Akiko Saito, Takahiko Shibahara Toshifumi Azuma.
- Journal Title
  
  BDJ Open
  
  Volume: 2 Issue: 1 Pages: 15007-15007
- DOI
  10.1038/bdjopen.2015.7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K20379, KAKENHI-PROJECT-25462900
[Journal Article] Glucose-PTS Involvement in Maltose Metabolism by <i>Streptococcus mutans</i>2015
- Author(s)
  Sato Y, Okamoto-Shibayama K, Azuma T.
- Journal Title
  
  Bull. Tokyo Dent. Coll.
  
  Volume: 56 Issue: 2 Pages: 93-103
- DOI
  10.2209/tdcpublication.56.93
- NAID
  130005078130
- ISSN
  0040-8891
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462900
[Journal Article] Akt Activation is Required for TGF-β1-Induced Osteoblast Differentiation of MC3T3-E1 Pre-Osteoblasts.2015
- Author(s)
  Suzuki E, Ochiai-Shino H, Aoki H, Onodera S, Saito A, Saito A, Azuma T
- Journal Title
  
  Plosons
  
  Volume: 9(12) Issue: 12 Pages: e112566-e112566
- DOI
  10.1371/journal.pone.0112566
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25462900, KAKENHI-PROJECT-25861761, KAKENHI-PROJECT-26861560, KAKENHI-PROJECT-26861686
[Journal Article] Additional Glucose-PTS Induction in <i>Streptococcus mutans Mutant</i> Deficient in Mannose- and Cellobiose-PTS2015
- Author(s)
  Sato Y, Okamoto-Shibayama K, Azuma T.
- Journal Title
  
  Bull. Tokyo Dent. Coll.
  
  Volume: 56 Issue: 3 Pages: 185-18
- DOI
  10.2209/tdcpublication.56.185
- NAID
  130005098144
- ISSN
  0040-8891
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462900
[Journal Article] Promoting effect of 1,25(OH)2 vitamin D3 in osteogenic differentiation from induced pluripotent stem cells to osteocyte like cells2015
- Author(s)
  Kato H, Ochiai-Shino H, Onodera S, Saito A, Takahiko Shibahara, Azuma T
- Journal Title
  
  Open Biology 5(2):140201
  
  Volume: 5(2) Issue: 2 Pages: 140201-140201
- DOI
  10.1098/rsob.140201
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25462900, KAKENHI-PROJECT-25861761, KAKENHI-PROJECT-26861560, KAKENHI-PROJECT-26861686
[Journal Article] A novel strategy for enrichment and isolation of osteoprogenitor cells from induced pluripotent stem cells based on surface marker combination.2014
- Author(s)
  Ochiai-Shino H, Kato H, Sawada T, Onodera S, Saito A, Takato T, Shibahara T, Muramatsu T, Azuma T.
- Journal Title
  
  PLOS ONE
  
  Volume: 9 Issue: 6 Pages: e99534-e99534
- DOI
  10.1371/journal.pone.0099534
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25462878, KAKENHI-PROJECT-25861761, KAKENHI-PROJECT-26861560, KAKENHI-PROJECT-26861686, KAKENHI-PROJECT-25462900
[Journal Article] Suppression of Lefty expression in induced pluripotent cancer cells.2013
- Author(s)
  Saito A, Ochiai H, Okada S, Miyata N, Azuma T.
- Journal Title
  
  Ｆａｓｅｂ　Ｊ
  
  Volume: 27(6) Issue: 6 Pages: 2165-74
- DOI
  10.1096/fj.12-221432
- Data Source
  KAKENHI-PROJECT-25462900
[Journal Article] 脂肪肝の原因とフォローアップ2006
- Author(s)
  東俊文
- Journal Title
  
  総合臨床 54・5
  
  Pages: 1647-1647
- Data Source
  KAKENHI-PROJECT-17590682
[Patent] 骨前駆細胞2014
- Inventor(s)
  東　俊文
- Industrial Property Rights Holder
  東　俊文
- Industrial Property Rights Type
  特許
- Filing Date
  2014-03-12
- Data Source
  KAKENHI-PROJECT-25462900
[Presentation] NOTCH2遺伝子変異を伴うHajdu-Cheney症候群疾患特異的iPS細胞を用いた破骨細胞分化誘導2023
- Author(s)
  間　奈津子、大野建州、齋藤暁子、加藤宏、小野寺晶子、東　俊文
- Organizer
  第41回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-23K09342
[Presentation] 骨芽細胞におけるメカニカルストレス応答分子機構の解明2023
- Author(s)
  山下悠、中村貴、奥平貴人、溝口利英、東俊文、西井康
- Organizer
  第315回東京歯科大学学会(例会)
- Data Source
  KAKENHI-PROJECT-20H03853
[Presentation] Induction of osteoclast differentiation of Hajdu-Cheney Syndrome-specific iPS cells2022
- Author(s)
  Natsuko Aida, Tatsukuni Ohno, Takashi Nakamura, Akiko Saito, Shajedul Isram, Shoko Onodera, Toshifumi Azuma
- Organizer
  第74回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-20K10170
[Presentation] Hajdu-Cheney症候群疾患特異的iPS細胞を用いた破骨細胞分化誘導2022
- Author(s)
  間奈津子、大野建州、中村貴、齋藤暁子、小野寺晶子、加藤宏、青木栄人、東俊文
- Organizer
  第54回日本臨床分子形態学会　総会・学術集会
- Data Source
  KAKENHI-PROJECT-20K10170
[Presentation] Gorlin症候群患者由来iPS細胞の上皮細胞分化誘導と紫外線照射時の反応2021
- Author(s)
  森田奈那,小野寺晶子,中村ゆり子,長谷川大悟,渡邊豪士,秀島樹,髙橋慎一,野村武史,松浦信幸,東俊文
- Organizer
  第66回日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-19H03833
[Presentation] Gorlin症候群診断遺伝子パネル開発とその信頼性の検証2021
- Author(s)
  中村ゆり子,小野寺晶子,秀島　樹, 森田奈那,髙野正行,片倉　朗,東　俊文,野村武史
- Organizer
  第65回日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21H03146
[Presentation] Gorlin症候群患者由来iPS細胞の上皮細胞分化誘導と紫外線照射時の反応2021
- Author(s)
  森田奈那,小野寺晶子,中村ゆり子,長谷川大悟,渡邊豪士,秀島樹,髙橋慎一,野村武史,松浦信幸,東俊文.
- Organizer
  第53回日本臨床分子形態学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-21H03146
[Presentation] リキッドバイオプシーで応用可能なGorlin症候群診断遺伝子パネルの開発2021
- Author(s)
  中村ゆり子,小野寺晶子,秀島　樹,髙野正行,片倉　朗,東　俊文,野村武史
- Organizer
  第311回東京歯科大学学会
- Data Source
  KAKENHI-PROJECT-19H03833
[Presentation] 『核とミトコンドリア研究』から見えてきた疾患病態の先端分子生物学）Runx2 はLINCタンパク質発現調節により骨芽細胞分化を制御する。2021
- Author(s)
  東　俊文、齋藤暁子、中村貴
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H03833
[Presentation] 『核とミトコンドリア研究』から見えてきた疾患病態の先端分子生物学）Runx2 は　LINCタンパク質発現調節により骨芽細胞分化を制御する。2021
- Author(s)
  東　俊文、齋藤暁子、中村貴
- Organizer
  第44回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H03146
[Presentation] 骨細胞のLamin Aは骨リモデリングを制御する。2021
- Author(s)
  奥平　貴人，中村貴 2，齋藤暁子 2，山口朗 1，髙野正行 3，柴原孝彦 3，東俊文 1.2
- Organizer
  第53回日本臨床分子形態学会総会・学術集会,
- Data Source
  KAKENHI-PROJECT-21H03146
[Presentation] 骨細胞のLamin Aは骨リモデリングを制御する。2021
- Author(s)
  奥平　貴人，中村貴，齋藤暁子，山口朗，髙野正行，柴原孝彦, 東俊文
- Organizer
  第53回日本臨床分子形態学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19H03833
[Presentation] Gorlin症候群患者由来iPS細胞の上皮細胞分化誘導と紫外線照射時の反応2021
- Author(s)
  森田奈那,小野寺晶子,中村ゆり子,長谷川大悟,渡邊豪士,秀島樹,髙橋慎一,野村武史,松浦信幸,東俊文
- Organizer
  第66回日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21H03146
[Presentation] Gorlin症候群診断遺伝子パネル開発とその信頼性の検証2021
- Author(s)
  中村ゆり子,小野寺晶子,秀島　樹, 森田奈那,髙野正行,片倉　朗,東　俊文,野村武史
- Organizer
  第65回日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-19H03833
[Presentation] Gorlin症候群患者由来iPS細胞の上皮細胞分化誘導と紫外線照射時の反応2021
- Author(s)
  森田奈那,小野寺晶子,中村ゆり子,長谷川大悟,渡邊豪士,秀島樹,髙橋慎一,野村武史,松浦信幸,東俊文
- Organizer
  第53回日本臨床分子形態学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19H03833
[Presentation] Gorlin症候群診断遺伝子パネルを用いた歯原性角化嚢胞の解析2021
- Author(s)
  秀島　樹,中村ゆり子,小野寺晶子,森田奈那,加藤禎彬,吉田秀児, 野村武史,髙野正行,東俊文,片倉　朗.
- Organizer
  第66回日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21H03146
[Presentation] 骨芽細胞RUnx2 は核膜タンパク質発現制御を通じて核形態および骨芽細胞分化を制御する。2021
- Author(s)
  東　俊文、齋藤暁子、中村貴
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21H03146
[Presentation] Gorlin症候群診断遺伝子パネルを用いた歯原性角化嚢胞の解析2021
- Author(s)
  秀島　樹,中村ゆり子,小野寺晶子,森田奈那,加藤禎彬,吉田秀児, 野村武史,髙野正行,東俊文,片倉　朗
- Organizer
  第66回日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-19H03833
[Presentation] 骨芽細胞RUnx2 は核膜タンパク質発現制御を通じて核形態および骨芽細胞分化を制御する。2021
- Author(s)
  東　俊文、齋藤暁子、中村貴
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H03833
[Presentation] 三叉神経節ニューロンの機械刺激感受性2019
- Author(s)
  東川明日香，木村麻記，戸田はる菜，隝田みゆき，大房航，大山定男，河野恭祐，望月浩之，澁川義幸
- Organizer
  第61回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-19H03833
[Presentation] 象牙質痛メカニズムの解析:in Vivo study2019
- Author(s)
  大山定男，人見涼露，東川明日香，大房航，戸田はる菜，黒田英孝，木村麻記，小野堅太郎，澁川義幸
- Organizer
  第61回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-19H03833
[Presentation] モデルラットを用いた象牙痛発生メカニズムの解析2019
- Author(s)
  大山定男　木村麻記　東川明日香　澁川義幸
- Organizer
  第18回釧路ニューロサイエンスワークショップ
- Data Source
  KAKENHI-PROJECT-19H03833
[Presentation] ヒト象牙芽細胞の機械刺激は細胞内遊離Ca2+濃度を増加する2019
- Author(s)
  松永真由美、木村麻記、戸田はる菜、石﨑元樹、矢﨑龍彦、大山定男、大房航、井上博之、東川明日香、澁川義幸、一戸達也
- Organizer
  第18回釧路ニューロサイエンスワークショップ
- Data Source
  KAKENHI-PROJECT-19H03833
[Presentation] ヒト象牙芽細胞における機械刺激誘発性細胞内遊離Ca2+濃度増加2019
- Author(s)
  松永真由美、木村麻記、戸田はる菜、大山定男、大房航、東川明日香、澁川義幸、一戸達也
- Organizer
  第61回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-19H03833
[Presentation] 三叉神経節ニューロンにおける炎症と疼痛に関与するP2X受容体の生理学的特性2019
- Author(s)
  上博之、黒田英孝、大山定男、石崎元樹、松永真由美、矢崎龍彦、東川明日香、木村麻記、澁川義幸、一戸達也
- Organizer
  第18回釧路ニューロサイエンスワークショップ
- Data Source
  KAKENHI-PROJECT-19H03833
[Presentation] 三叉神経節ニューロンにおけるPanexin-1チャネルを介したP2X7-P2X4受容体の機能連関2019
- Author(s)
  黒田英孝，井上博之，東川明日香，木村麻記，石川昂，城戸幹太，半田俊之，今泉うの，澁川義幸，一戸達也
- Organizer
  第24回日本口腔顔面痛学会学術大会
- Data Source
  KAKENHI-PROJECT-19H03833
[Presentation] ラット三叉神経節ニューロンにおけるP2X7 受容体-pannexin-1 チャネル-P2X4 受容体相互作用の電気生理学的機能検索2019
- Author(s)
  井上博之，黒田英孝，石川昂，大山定男，東川明日香，木村麻記，澁川義幸，一戸達也
- Organizer
  第61回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-19H03833
[Presentation] 骨芽細胞の機械感受性イオンチャネル発現2019
- Author(s)
  永井佐代子、戸田はる菜、大山定男、大房航、東川明日香、木村麻記、澁川義幸、片倉朗
- Organizer
  第61回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-19H03833
[Presentation] ラット扁平上皮癌細胞の機械感受性イオンチャネル2019
- Author(s)
  石崎元樹, 戸田はる菜, 大山定男, 大房航, 東川明日香, 木村麻記, 澁川義幸, 一戸達也
- Organizer
  第61回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-19H03833
[Presentation] 三叉神経節ニューロンの機械刺激誘発性細胞間コミュニケーション2019
- Author(s)
  矢﨑龍彦、大山定男、大房航、戸田はる菜、石﨑元樹、松永真由美、井上博之、東川明日香、木村麻記、澁川義幸、一戸達也
- Organizer
  第18回釧路ニューロサイエンスワークショップ
- Data Source
  KAKENHI-PROJECT-19H03833
[Presentation] ラット扁平上皮癌の機械感受性イオンチャネル2019
- Author(s)
  石崎元樹、松永真由美、矢崎龍彦、井上博之、戸田はる菜、東川明日香、木村麻記、黒田英孝、澁川義幸、一戸達也
- Organizer
  第18回釧路ニューロサイエンスワークショップ
- Data Source
  KAKENHI-PROJECT-19H03833
[Presentation] セメント芽細胞におけるCa2+活性化K+チャネル発現2019
- Author(s)
  鎌田聡仁，東川明日香，木村麻記，井上博之，大山定男，大房航，澁川義幸，山下秀一郎
- Organizer
  第61回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-19H03833
[Presentation] 象牙芽細胞におけるアルカリ刺激受容機構2019
- Author(s)
  木村麻記，東川明日香，戸田はる菜，大山定男，大房航，澁川義幸
- Organizer
  第61回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-19H03833
[Presentation] TGF-β1によるマウス前骨芽細胞の分化調節におけるPI3K/Aktシグナル伝達経路の役割2014
- Author(s)
  鈴木瑛一、落合(篠)宏美、青木栄人、小野寺晶子、齋藤暁子、齋藤淳、東俊文
- Organizer
  第297回東京歯科大学学会
- Place of Presentation
  東京
- Year and Date
  2014-06-08
- Data Source
  KAKENHI-PROJECT-25462900
[Presentation] iPS細胞から骨前駆細胞分化誘導および単離の新規方法開発と骨細胞様細胞への分化誘導
- Author(s)
  東俊文、齋藤暁子、小野寺晶子、加藤宏、篠宏美
- Organizer
  第32回日本骨代謝学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-07-08 – 2014-07-10
- Data Source
  KAKENHI-PROJECT-25462900
[Presentation] PS細胞から誘導した骨芽細胞を用いた創薬評価-活性型ビタミンD3の効果判定-
- Author(s)
  加藤宏、篠宏美、小野寺晶子、齋藤暁子、林宰央、長谷川大悟、柴原孝彦、東俊文
- Organizer
  第32回日本骨代謝学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-07-08 – 2014-07-10
- Data Source
  KAKENHI-PROJECT-25462900
[Presentation] TGF-β1 regulates osteoblast differentiation via PI3K/Akt signaling pathway
- Author(s)
  Suzuki E, Ochiai-Shino H, Aoki H, Hayashi T, Takahashi J, Azuma T, Saito
- Organizer
  TGF-β1 regulates osteoblast differentiation via PI3K/Akt signaling pathway
- Place of Presentation
  Gifu
- Year and Date
  2014-05-14 – 2014-05-16
- Data Source
  KAKENHI-PROJECT-25462900
[Presentation] iPS細胞から誘導した骨芽細胞を用いた創薬評価
- Author(s)
  加藤宏、篠宏美、小野寺晶子、齋藤暁子、林宰央、長谷川大悟、柴原孝彦、東俊文
- Organizer
  第68回日本口腔科学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-05-07 – 2014-05-09
- Data Source
  KAKENHI-PROJECT-25462900

1. 中村貴 (80431948)

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AZUMA TOSHIFUMI 東 俊文

AZUMA Toshifumi 東 俊文

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Development of a new treatment for fibrodysplasia using active genomics and high-throughput analysisPrincipal Investigator

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Elucidation of osteoblast mineralization mechanism using McCunealbright syndrome iPS cellsPrincipal Investigator

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Basic research for development of osteoregeneration therapy using mesenchymal stem cells and iPS cellsPrincipal Investigator

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Basic Research for Regeneration Therapy for Liver FailurePrincipal Investigator

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Splenic SP-cells offer the potential of autologous cell therapy aimed at liver regeneration.Principal Investigator

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AZUMA TOSHIFUMI 東俊文

AZUMA Toshifumi 東俊文

[Book] 期待されるチアゾリジン薬脂肪肝に対する作用2007