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NARIUCHI Hideo  成内 秀雄

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… Alternative Names

成内 秀雄  ナリウチ ヒデオ

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Researcher Number 10012741
Affiliation (based on the past Project Information) *help 2000: University of Tokyo Institute of Medical Science Department of Allergology Emeritus Professor, 医科学研究所, 名誉教授
1988 – 1999: 東京大学, 医科学研究所, 教授
1993: 東京大学医科学研究所, アレルギー部門, 教授
1986: 東大, 医科学研究所, 教授
1985: 東京大学, 医科研, 教授
Review Section/Research Field
Principal Investigator
Immunology / 内科学一般
Except Principal Investigator
Digestive surgery / Immunology / Biological Sciences / Bacteriology (including Mycology) / General surgery / 寄生虫学(含医用動物学) / 内科学一般 / 細菌学 / 老化(加齢)
Keywords
Principal Investigator
TNF / IL-12 / T細胞亜集団 / CD152 / CD28 / B7 / IL-12p35 / 腫瘍壊死 / 血管新生抑制 / トランスジェニックマウス … More / 細胞傷害性T細胞 / IL-12 independent TH1 differentiation / MHC class II / IL-2p40 / T細胞上B7-2発現 / T細胞抗原受容体 / 副刺激 / B7刺激 / IL-12Rβ2 / IL-12受容体 / IL-12非依存性Th1分化 / MHCクラスII / IL-12p40 / T helper cell subset / Interferon / Tumor necrosis factor / Cytokine / Inflammation / インターロイセン1 / 炎症反応 / 内毒素 / 腫瘍壊死因子 / Tヘルパー細胞亜集団 / インターフェロン / サイトカイン / 炎症 / CD4T細胞CD8T細胞 / 活性化T細胞 / 未知液性因子 / インターロイキン2受容体 / 血管内皮傷害作用 / 培養 / 増殖抑制 / 血管内皮細胞 / 肝転移モデル / IL-12p40トランスジェニックマウス / IRES / IL-12遺伝子導入腫瘍 / Fas-FasL反応 / 遺伝子導入 / 免疫記憶 / 移植腫瘍 / IL-12遺伝子 / B7分子 / IL-10 / Th2 / Th1 / CD40-CD40L / IL-12産生 / 遺伝子構造 / ナイーブとメモリー / シグナル伝達経路 / IL-2受容体 / 第二シグナル / ヘルパーT細胞 / 分離精製 / インターロイキン2受容体発現因子 … More
Except Principal Investigator
IFN-γ / IL-12 / ワクチン / CTLA-4 / CD28 / MHC Class II / NO / マラリア / Fc Receptor / p35 / BRM / Fas / point mutation / p-53 / ND2001 / HCFU / LMFS / MAIDS / 防御免疫 / 自己免疫病 / gp120 / HIV / Immunoliposome / vaccine / Thermal neutron / 中性子捕捉療法 / 熱中性子照射 / 硼素化合物 / 赤内型マラリア / 貪食能 / NK細胞 / 赤内型マラリア感染 / アポトーシス / Blood-Stage Malaria Infection / Autoimmune Diseases / IL-12 Receptor / IL-12 p40 / IL-12p35 / 貧食能 / MHCクラスII / Fc Beceptor / IL-12Receptor / IL-12p40 / Recombinant Virus / Pathogenesis / IFN-gamma. / Vaccine / Host Resistance / Malaria Infection / 感染防御 / 組み替えウイルス / 組み換えウイルス / 病態形成 / マラリア感染 / Chemical modification / receptor / Apoptosis / Cell death / Peptide / Antagonist / ペプチド合成 / 遮断剤 / 生体応答調節薬 / 化学修飾 / 受容体 / 細胞死 / ペプチド / アンタゴニスト / chemotherapy / Inhibition of metastasis / spontaneous liver metastasis / 浸潤 / 化学療法 / 転移抑制 / 自然肝転移 / fibroblast / wound healing / Criteria for surgical indications / Surgical operation / HIV-infected patient / 抗張力 / 引張力 / MAIDSマウス / 創傷治癒能 / 線維芽細胞 / 創傷治癒 / 手術適応基準 / 外科手術 / HIV感染者 / protective immunity / affinity chromatography / monoclonal antibody / electrophoresis / polypeptide / Western blot / malaria / 抗原蛋白 / 熱帯熱マラリア原虫 / アフインティクロマトグラフィ / モノクロナール抗体 / ウェスタンブロ-ト / アフィニティクロマトグラフィ / モノクローナル抗体 / 電気泳動 / ポリペプチド / ウエスタンブロット / idiotype network / lpr^<cg> gene / autoimmunity / 抗gp120抗体 / 自己免疫マウス / イディオタイプネットワーク / 1pr^<cg>遺伝子 / 自己免疫 / Anti-CEA monoclonal antibody / ^<10>B-compound / Boron neutron capture therapy (BNCT) / イムノリポソーム / 抗CEA単クローン抗体 / 熱中性子 / molecular genetics / cell invasion / recombinant DNA experiments / virulence / pathogenicity / Shigella flexneri / 免疫病理学 / 分子遺伝学的解析 / サル実験 / 赤痢 / 組換えDNA / 分子遺伝学 / 細胞侵入性 / 組換えDNA実験 / ビルレンス / 病原性 / 赤痢菌 / Anti CEA monoclonal antibody / Liposome / ^<10>B compound / Boron neutron capture therapy / 抗CEAモノクロナ-ル抗体 / 抗CEA単クロ-ン抗体 / リポソ-ム / 中性子捕促療法 / 2 / B7-1 / Retroviral Expression Cloning / Two-Hybrid Screening / IL-12 Rceptor / 細胞性免疫反応 / IFN-Y / 可溶性CD4 / DTH反応 / FcRγ鎖KOマウス / FcR / CD4^+T細胞 / 防御免疫機構 / 細胞増殖 / 情報伝達 / レセプター / 免疫病 / 免疫異常 / 抗原受容体 / 増殖抑制 / STAT / リンパ球 / シグナル伝達 / サイトカイン / 感染免疫防御 / 加齢 / 細胞内情報伝達 / T細胞 Less
  • Research Projects

    (29 results)
  • Co-Researchers

    (41 People)
  •  Th1反応における情報伝達制御機構の解明-IL-12Rを介したIFN-γ産生へのシグナル伝達-

    • Principal Investigator
      善本 隆之
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical University
  •  マラリア感染に対する防御免疫機構-赤内型P.berghel強毒株NK65とその弱毒株XATを用いた解析-

    • Principal Investigator
      善本 隆之
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      The University of Tokyo
  •  免疫機能低下の機構解明

    • Principal Investigator
      善本 隆之
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Studies on the regulation of IL-12 expression and function and its application to therapy

    • Principal Investigator
      YOSHIMOTO Takatyuki
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Tokyo Medical University
      The University of Tokyo
  •  マラリア感染における防御免疫機構の研究-赤内型P.berghei強毒株NK65とその弱毒株XATを用いた検討-

    • Principal Investigator
      善本 隆之
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      The University of Tokyo
  •  IL-12遺伝子導入腫瘍を用いた抗腫瘍効果機序の基礎的研究Principal Investigator

    • Principal Investigator
      成内 秀雄
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  Study on the role of IL-12 in protective immunity against infection

    • Principal Investigator
      YOSHIMOTO Takayuki
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
  •  Elucidation of T cell subset Th1 differentiation by IL-12Principal Investigator

    • Principal Investigator
      NARIUCHI Hideo
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
  •  IL-12遺伝子をもちいた癌免疫療法開発の基礎的研究Principal Investigator

    • Principal Investigator
      成内 秀雄
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  IL-12による弱毒化マラリア原虫のワクチン効果増強に関する基礎的研究

    • Principal Investigator
      善本 隆之
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  情報伝達とリンパ球の機能分化

    • Principal Investigator
      宮園 浩平
    • Project Period (FY)
      1996 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Japanese Foundation For Cancer Research
  •  Molecular design of BRMs using synthetic peptide libraries

    • Principal Investigator
      OHMI Shinobu
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      The University of Tokyo
  •  T細胞亜集団による免疫制御の分子機構Principal Investigator

    • Principal Investigator
      成内 秀雄
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  IL-12遺伝子をもちいた癌免疫療法開発の基礎的研究Principal Investigator

    • Principal Investigator
      成内 秀雄
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  INVESTIGATION OF SPONTANEOUS LIVER METASTASIS MODEL OF BALB/c REIROPERITONEAL SARCOMA (LMFS) AND CLINICAL APPLICATION

    • Principal Investigator
      FUJII Yuzo
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      The University of Tokyo
  •  T細胞亜集団による免疫制御の分子機構Principal Investigator

    • Principal Investigator
      成内 秀雄
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  Studies on purification isolation and immunological characterization of 47kD and 23kD polypeptide from blood stage P.falciparum parasite

    • Principal Investigator
      SUZUKI Mamoru
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      寄生虫学(含医用動物学)
    • Research Institution
      Gunma University School of Medicine
  •  Study for wound healing in HIV-infected patients

    • Principal Investigator
      ERIGUCHI Masazumi
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      The University of Tokyo
  •  T細胞亜集団による免疫制御の分子機構Principal Investigator

    • Principal Investigator
      成内 秀雄
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  T細胞におけるシグナル伝達の分子機能:その加齢変化

    • Principal Investigator
      宇津山 正典
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      老化(加齢)
    • Research Institution
      Tokyo Metropolitan Institute of Gerontology
  •  Role of anti-HIV-gp120 antibody in the lpr^<cg> and other autoimmune mice.

    • Principal Investigator
      KIMURA Mikio
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo
  •  Analysis of cytokine cascade in inflammatory reaction and application for the regulationPrincipal Investigator

    • Principal Investigator
      NARIUCHI Hideo
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo
  •  Application of monoclonal antibody against solid tumor to boron neutron capture therapy model

    • Principal Investigator
      FUJII Yuzo
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      The University of Tokyo
  •  Developement of live attenuated anti-Shigella vaccine based on molecular pathogenesis studies

    • Principal Investigator
      YOSHIKAWA Masanosuke
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      細菌学
    • Research Institution
      The University of Tokyo
  •  ILー2受体発現増強因子を用いたキラーT細胞高能率誘導法Principal Investigator

    • Principal Investigator
      成内 秀雄
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  Application of Anti CEA-Immunoliposome to boron neutron capture therapy

    • Principal Investigator
      FUJII Yuzo
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      The Institute of medical Science, University of Tokyo
  •  IL-2受容体発現増強因子を用いた抗腫瘍活性細胞誘導の試みPrincipal Investigator

    • Principal Investigator
      成内 秀雄
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  TNF(腫瘍壊死因子)の抗腫瘍活性機序の解明Principal Investigator

    • Principal Investigator
      成内 秀雄
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      The University of Tokyo
  •  TNF(腫瘍壊死因子)の抗腫瘍活性機序の解明Principal Investigator

    • Principal Investigator
      成内 秀雄
    • Project Period (FY)
      1985
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      The University of Tokyo
  • 1.  YOSHIMOTO Takayuki (80202406)
    # of Collaborated Projects: 15 results
    # of Collaborated Products: 0 results
  • 2.  KATO Takuma (60224515)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 3.  FUJII Yuzo (40143515)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  脇 誠治 (10056286)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  TOMITA Toshio (00126129)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  KOBAYASHI Hisao (10062605)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  YANAGIE Hironobu (30212278)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  MORI Shigero (30010424)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  MATSUZAWA Akio (50012745)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  平良 珠美子 (80154722)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  SEKIGUCHI Morimasa (60012712)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  YOSHIKAWA Masanosuke (80012714)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  SASAKAWA Chihiro (70114494)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  DANBARA Hirobumi (40114558)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  SHIMADA Hiroyuki (60113487)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  TAKASAKA Masao (80072924)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  KIMURA Mikio (90114462)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  SUZUKI Mamoru (60056033)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  NAKAMURA Masatoshi (10251092)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  KANO Shigeyuki (60233912)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  ERIGUCHI Masazumi (10114406)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  OHMI Shinobu (20160046)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  NAKATA Ko (80207802)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  TAMURA Toshiki (40291306)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  宇津山 正典 (70167287)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  広川 勝〓 (00014093)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  白沢 卓二 (80226323)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  石島 早苗 (80147214)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  宮園 浩平 (90209908)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  渡邊 武 (40028684)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  田賀 哲也 (40192629)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  吉村 昭彦 (90182815)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  徳久 剛史 (20134364)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  宮島 篤 (50135232)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  菅村 和夫 (20117360)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  江川 滉二 (00012724)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  原中 勝征 (90012757)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  高橋 司 (90143510)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 39.  木村 哲 (60010352)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 40.  SAEGUSA Yoshiyuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 41.  TSUJI Moriya
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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