HAYASHI Masahiro 林正弘

Researcher Number	20012669
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2003 – 2011: 東京薬科大学, 薬学部, 教授 2001: Tokyo University of Pharmacy and Life Science,School of Pharmacy,Professor, 薬学部, 教授 2000: School of Pharmacy, Tokyo University of Pharmacy and Life Science, Professor, 薬学部, 教授 1998 – 1999: 東京理科大学, 薬学部, 教授 1992 – 1996: 東京理科大学, 薬学部, 教授 … More 1988 – 1991: 東京薬科大学, 薬学部, 助教授 1986: Tokyo College of Pharmacy, 薬学部, 助教授 1986: Tokyo College of Pharmacy, 薬学部, 助教授 Less
Review Section/Research Field	Principal Investigator 応用薬理学・医療系薬学 / Medical pharmacy Except Principal Investigator Physical pharmacy / 医薬分子機能学 / Biological pharmacy / Medical pharmacy
Keywords	Principal Investigator P-glycoprotein / 吸収促進剤 / Tight Junction / 細胞間隙経路 / 細胞内ルート / 細胞間ルート / 吸収部位差 / microsome / in vitro / P450 … More / 膜抵抗 / Paracellular Pathway / インピ-ダンス解析 / 結腸 / 空腸 / Caco-2細胞 / 炎症性腸疾患 / 腸管吸収 / 末梢血リンパ球 / 感染症 / Simultaneous Luminal and Vascular Perfusion / Blood Flow Dependence / Membrane Perturbation / Impedance Analysis / Equivalent Pore Radius / Absorptive Site Difference / Transcellular Route / Intercellular Route / 膜透過律速 / 血流律速 / 膜perturbation / Eguivalent Pore半径 / 血管壁透過性 / 吸収部位血流 / Voltage Clamp法 / 腸管血菅同時潅流法 / アクチン-ミオシンリング / Tight junction / 腸管血管同時潅流法 / 血流依存性 / 膜Perturbation / Equivalent ポア-半径 / 細胞内ル-ト / 細胞間ル-ト / fluorescence polarization / pore radius / water absorption / transcellular route / paracellular route / absorption promoter / 膜流動性 / 蛍光偏光解消法 / 細孔サイズ / 血流 / 水の吸収 / Gene Diagnosis / Inflammation Bowel Diseases / reperfusion / Ischemia / Infective diseases / Peripheral Lymphocyte / Absorption Enhancement / P-Glycoprotein / mdr1a mRNAレベル / トランスポーター / 免疫抑制剤 / 小腸虚血再灌流 / 末梢リンパ球 / 遺伝子診断 / 虚血再灌流 / 吸収改善 / P-glyco@rotein / absorption enhancer / tight junction / paracellular pathway / hydrogen peroxide / active oxygen compounds / neutrophil / oligopeptide / 過酸化水素 / 活性酸素種 / 好中球 / オリゴペプチド / enzyme induction / recombinant human CYP isoforms / enzyme inhibition / drug interaction / ヒトCYP発現系 / 酵素誘導 / 酵素阻害 / 薬物相互作用 / Membrane Permeability / Electrophysiology / Damage Score / Short Circuit Current / Membrane Resistance / Inflammatory Bowel Disease Model / 膜電位 / 免疫抑制酸性蛋白 / 粘膜炎症 / 膜透過性 / 電気生理学 / ダメ-ジスコアー / 短絡電流 / 炎症性腸疾患モデル / Adsorptive Endocytosis / Peyer's Patches / Caprate / Caco-2 Cells / Actomyosin / Polypeptide / Absorption Enhancer / 高分子量物質 / 細胞内経路 / Caco‐2細胞 / M細胞 / 細胞間隙 / 高分子ペプチド / カルモジュリン / 吸着性エンドサイトーシス / パイエル板 / カプリン酸 / アクトミオシン / ポリペプチド / Methylprednisolone / Dextran sodium sulfate / 必須不飽和脂肪酸 / P-glycoproein / Dextran Sodium Sulfate / 必須不飽和脂肪 / 栄養療法 / 薬物療法 / methylpredonisolone / Lypopolysaccaride / bcrp / mrp2 / mdr1a / 非侵襲的体内動態予測システム / PXR / 感染症病態モデル / ABCトランスポーター / 非侵襲的動態予測 / 核内レセプター / 肝臓 / 回腸 / ABC トランスポーター / Lipopolysaccharide / 代謝学 / 薬物動態 … More Except Principal Investigator 腸管吸収 / Caco-2 / 肝細胞 / BLMV / BBMV / GLUT5 / omeprazole / phenobarbital / 培養細胞 / 吸収促進剤 / cell culture / intestinal absorption / ペプチド性医薬品 / インスリン / Acetaminophen / Fluorescent Substance / Liver Microsome / Hepatocyte / Glutathione / Lipid Peroxidation / Hepatotoxicity / Drug Toxicity / 蛍光寿命 / 肝ミクロゾーム / 蛍光物質 / 肝ミクロゾ-ム / 四塩化炭素 / 蛋白重合体 / アセトアミノフェン / 蛍光性物質 / 肝ミクロソ-ム / グルタチオン / 脂質過酸化 / 肝毒性 / 薬物毒性 / binding protein / transcellular route / paracellular route / absorption promoter / membrane permeability / Albumin / hepatocyte / 骨格筋 / 結合タンパク / 細胞内ルート / 細胞間ルート / 膜透過性 / アルブミン / Caco-2 cells / sulfate conjugation metabolism / intestinal metabolism / drug-nutrient interactions / drug-drug interactions / bioavailability / intestinal availability / 薬物速度論 / 食物成分 / 飲食物 / 相互作用 / カテキン / 抱合代謝 / Caco-2細胞 / 硫酸抱合代謝 / 腸管代謝 / 薬物飲食物間相互作用 / 薬物間相互作用 / バイオアベイラビリティ / 腸管アベイラビリティ / fructosylated peptide / peptide drugs / transporter / フルクトシルペプチド / トランスポーター / prediction / Enzyme induction / HepG2 / CYP2B / CYP1A / 初代培養肝細胞 / Hep G2 / 予測 / 酵素誘導 / electroosmosis / insulin / microdevice / glucose sensor / reverse iontophoresis / iontophoresis / artificial pancreas / transdermal type / グルコース / グルコースオキシダーゼ / 電気浸透 / マイクロデバイス / グルコースセンサー / 逆イオントフォレシス / イオントフォレシス / 人工膵島 / 経皮吸収型 / Peyer's Patch / Concanvaline A / Intestinal / Peptide / Microsphere / Bioadhensive / Absorption enhancement / エンドサイトーシス / 小腸パイエル板 / 保水効果 / ポリカーボフィル / 粘膜付着性マイクロカプセル / ヒト結腸 / Coco-2細胞 / パイエル板 / Concanavaline A / 消化管吸収 / ペプチド / マイクロスフェア- / 粘膜接着 / 吸収促進 / Peptide drug / Drug targeting / Drug absorption / Cell membrane permeation / Physiological model / Pharmacokinetics / 鎮痛薬 / ペプチド薬物 / 薬物ターゲッティング / 薬物吸収 / 細胞膜透過 / 生理学的モデル / 薬物体内動態 / crypt cell / L1210 murine leukemia cell / intestinal damage / D-glucose / methotrexate / vitamin A / Dーグルコ-ス / メトトレキサ-ト / L-ロイシン / 小腸培養細胞IEC-6 / 抗癌作用 / 小腸粘膜 / マウス肉腫細胞ザルコーマ180 / 細胞培養 / 小腸クリプト細胞 / マウス白血病細胞L1210 / 消化器障害 / D-グルコース / メトトレキサート / ビタミンA / グルコース輸送担体 / 小腸刷子縁膜小胞 / 血糖降下作用 / グリコシル化 Less

Improvement of inflammatory bowel diseases based on expression and functional changes of P-glycoprotein by methylpredonislone and essential fatty acidsPrincipal Investigator
- Principal Investigator
  
  HAYASHI Masahiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
New Prediction System of Infective Disease Based on Changes in Expression and Function of ABC TransporterPrincipal Investigator
- Principal Investigator
  
  HAYASHI Masahiro
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
Improvement of intestinal drug absorption based on structural changes of tight junction and functional changes of P-glycoproteinPrincipal Investigator
- Principal Investigator
  
  HAYASHI Masahiro
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Sciences
Intestinal absorption of dietary compounds and quantitative analysis of their influences on drug absorption
- Principal Investigator
  
  MIZUMA Takashi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Sciences
Improvement of intestinal absorption of peptide drugs
- Principal Investigator
  
  HAGA Makoto
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Tokyo University of Science
Intestinal Drug Absorption and Excretion-Detoxication Using Regulation of Membrane Permeation by Oligopeptide-produced NeutrophilsPrincipal Investigator
- Principal Investigator
  
  HAYASHI Masahiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  School of Pharmacy, Tokyo University of Pharmacy and Life Science
  Tokyo University of Science
Development of quantitative prediction method for P450 induction
- Principal Investigator
  
  OKUDAIRA Kazuho
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Science University of Tokyo
Development of in vitro screening system for CYP based drug interactionPrincipal Investigator
- Principal Investigator
  
  HAYASHI Masahiro
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Faculty of Pharmaceutical Sciences, Science University of Tokyo
Development of a transdermal type of artificail pancreas
- Principal Investigator
  
  HAGA Makoto
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Faculty of Pharmaceutical Sciences, Science University of Tokyo
Physiological and Biochemical Assessment of Membrane Barrier Function in Inflammatory DiseasePrincipal Investigator
- Principal Investigator
  
  HAYASHI Masahiro
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Faculty of Pharmaceuticla Sciences, Science University of Tokyo
インスリンのグリコシル化による腸管吸収改善とその機構
- Principal Investigator
  
  HAGA Makoto
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Tokyo University of Science
Prediction and control effectiveness and safety of a drug by means of pharmacokinetics based on physiological and biochemical mechanism of its disposition in body.
- Principal Investigator
  
  HANANO Manabu
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Nihon University
Development of Oral Dosage form for Poorly Absorbable Drugs
- Principal Investigator
  
  AWAZU Shojii
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
A Study on Protective Effect of Vitamin A against Antitumour Drug-Induced Damage to Small Intestine
- Principal Investigator
  
  HORIE Toshiharu
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokyo College of Pharmacy
Membrane Permeability and Its Improvement in Intestinal Absorption of Macromolecular DrugsPrincipal Investigator
- Principal Investigator
  
  HAYASHI Masahiro
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Faculty of Pharmaceutical Sciences, Science University of Tokyo
  Tokyo University of Pharmacy and Life Science
Quantitative Evaluation and Prediction of Drug-Toxicity Due to Lipid Peroxidation
- Principal Investigator
  
  HORIE Toshiharu
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
Physiological and Anatomical Factors Controlling Intestinal Drug Absorption MechanismPrincipal Investigator
- Principal Investigator
  
  HAYASHI Masahiro
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tokyo University of Pharmacy and Life Science
Mechanism for the Enhancement of Intestinal Paracellular and Transcellular Permeability by Absorption PromotersPrincipal Investigator
- Principal Investigator
  
  MASAHIRO Hayashi
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tokyo College of Pharmacy
Factors in Cell Membrane Transport and Tissue Distribution of Drugs
- Principal Investigator
  
  AWAZU Shoji
- Project Period (FY)
  1984 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Tokyo College of Pharmacy

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All Journal Article Presentation Book

[Book] 医薬品トキシコロジー改訂版第3版2006
- Author(s)
  富田幹雄, 林正弘
- Total Pages
  289
- Publisher
  南圧堂
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590140
[Book] 薬と疾病I 、薬の効くプロセス、スタンダード薬学シリーズ 62005
- Author(s)
  富田幹雄, 林正弘
- Total Pages
  409
- Publisher
  東京科学同人
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590140
[Journal Article] Changes in protein and mRNA expression levels of claudin family after mucosal lesion by intestinal ischemia/reperfusion2012
- Author(s)
  Y. Takizawa, H. Kishimoto, T. Kitazato, M. Tomita and M. Hayashi
- Journal Title
  
  Int. J. Pharm.
  
  Volume: 426 Pages: 82-89
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590182
[Journal Article] Effects of antioxidants on the ischemia/reperfusion injury in rat2011
- Author(s)
  Y.Takizawa, H.Kishimoto, T.Kitazato, M.Tomita, M.Hayashi
- Journal Title
  
  Eur.J.Drug Metab.Pharmacokinet.
  
  Volume: 35 Issue: 3-4 Pages: 89-95
- DOI
  10.1007/s13318-010-0020-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590182
[Journal Article] Changes in the pharmacokinetics of rhodamine123 and bromosulfophtalein in rats treated with lipopolysaccharide2011
- Author(s)
  M. Tomita, M. Hatanaka, M. Nakaike, T. Kai, C. Kobayashi, H. Murata, A. Tanaka, A. Kanbayashi and M. Hayashi
- Journal Title
  
  Organ Biol.
  
  Volume: 18 Pages: 145-150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590182
[Journal Article] Nonlinear intestinal absorption of fluorescein isothiocyanate dextran 4, 000 caused by absorptive and secretory transporting system2011
- Author(s)
  M. Tomita, R. Ohkubo, S. Ouchi, C. Kawahata and M. Hayashi
- Journal Title
  
  Pharmacol. Pharm.
  
  Volume: 2 Pages: 173-179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590182
[Journal Article] Effect of aminoguanidine on ischemia/reperfusion injury in rat small intestine2011
- Author(s)
  Y.Takizawa, H.Kishimoto, T.Kitazato, M.Tomita, M.Hayashi
- Journal Title
  
  Biol.Pharm.Bull.
  
  Volume: 34(11) Pages: 1737-1743
- NAID
  130001252858
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590182
[Journal Article] Absorption enhancement of acylcarnitine through changes in tight junction protein in Caco-2 Cell monolayers2011
- Author(s)
  N.Doi, M.Tomita, M.Hayashi
- Journal Title
  
  Drug Metab.Pharmacokinet.
  
  Volume: 26(2) Issue: 3 Pages: 162-170
- DOI
  10.1016/j.ejps.2010.11.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590182
[Journal Article] Regional difference of drug permeability in the rat intestine, determined using markers of the paracellular, transcellular and some transporter routes2010
- Author(s)
  M.Tomita, M.Hayashi, et al
- Journal Title
  
  Organ Biol.
  
  Volume: 17 Pages: 77-87
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590182
[Journal Article] Effect of lipopolysaccharide on P-glycoprotein-mediated intestinal and biliary excretion of rhodamine123 in rats2010
- Author(s)
  M.Tomita, M.Hayashi, et al
- Journal Title
  
  Int.J.Pharm.
  
  Volume: 392 Pages: 35-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590182
[Journal Article] Nonlinear intestinal absorption of methylprednisolone caused by absorptive and secretory transporters2010
- Author(s)
  M.Tomita, M.Hayashi, et al.
- Journal Title
  
  International Journal Pharmaceutics 387
  
  Pages: 1-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590182
[Journal Article] Effects of acylcarnitines on efflux transporting system in Caco-2 cell monolayers2010
- Author(s)
  M.Tomita, M.Hayashi, et al
- Journal Title
  
  Eur.J.Drug Metab.Pharmacokinet.
  
  Volume: 35 Pages: 1-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590182
[Journal Article] Effects of lauroylcarnitine and palmitoylcarnitone on transport of ranitidine in human intestinal epithelial Caco-2 cell monolayers2008
- Author(s)
  M. Tomita, N. Doi, and M. Hayashi
- Journal Title
  
  Organ Biology 15(4)
  
  Pages: 377-385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590156
[Journal Article] Effects of lauroylcarnitine and palmitoylcarnitone on transport of ranitidine in human intestinal epithelial Caco-2 cell monolayers2008
- Author(s)
  M. Tomita, N. Doi, M. Hayashi
- Journal Title
  
  Organ Biology 15(4)
  
  Pages: 377-385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590156
[Journal Article] Assessment of ileale p i t h e l i a l P - g l y c o p r o t e i n dysfunction induced by ischemia / reperfusion using in vivo animal model2008
- Author(s)
  M. Tomita, Y. Takizawa, H. Kishimoto, and M. Hayashi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics 23(5)
  
  Pages: 356-368
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590156
[Journal Article] Mechanistic Analysis for Drug Permeation Through Intestinal Membrane.2007
- Author(s)
  M. Hayashi and M. Tomita
- Journal Title
  
  Drug Metabolism and Pharmacokinetics 22(2)
  
  Pages: 67-77
- NAID
  10019923140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590156
[Journal Article] Differentiation of organ availability by sequential and simultaneous analyses : Intestinal conjugative metabolism impacts on intestinal availability in humans.2005
- Author(s)
  Mizuma T, Kawashima K, Sakai S, Sakaguchi S, Hayashi M.
- Journal Title
  
  J Pharm Sci 94(3)
  
  Pages: 571-575
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Simultaneous HPLC assay of lenampicillin (ampicillin prodrug), ampicillin, and marker compound for high - throughput in vitro assessment of intestinal absorption in vitro assessment of intestinal absorption2005
- Author(s)
  Takashi Mizuma, Sayaka Sakaguchi, Masahiro Hayashi
- Journal Title
  
  J. Liq. Chromtogr. Rel. Technol. 28
  
  Pages: 1531-1537
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Kinetic characterization of glycosidase activity from disaccharide conjugate to monosaccharide conjugate in Caco-2 cells.2005
- Author(s)
  Takashi Mizuma, Norihiko Fuseda, Masahiro Hayashi.
- Journal Title
  
  J.Pharm.Pharmacol. 57
  
  Pages: 661-664
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Intestinal SGLT1-mediated absorption and metabolism of benzyl β-glucoside contained in Purunus mume : carrier-mediated transport increases intestinal availability.2005
- Author(s)
  Takashi Mizuma, Maya Nakamura, Hiroji Ina, Toshio Miyazaki, Masahiro Hayashi.
- Journal Title
  
  Biochim.Biophys.Acta. 1722
  
  Pages: 218-223
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Differentiation of organ availability by sequential analysis and simultaneous analysis : intestinal conjugative metabolism impacts on intestinal availability in humans2005
- Author(s)
  Takashi Mizuma, Kosuke Kawashima, Shuichi Sakai, Sayaka Sakaguchi, Masahiro Hayashi
- Journal Title
  
  J.Pharm.Sci. 94
  
  Pages: 571-575
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Tight junction およびP-糖蛋白質の機能修飾に基づいた薬物吸収改善2005
- Author(s)
  富田幹雄, 林正弘
- Journal Title
  
  Drug Delivery System 20(4)
  
  Pages: 416-423
- NAID
  10016673153
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590140
[Journal Article] Tight JunctionおよびP-糖タンパク質の機能修飾に基づいた薬物吸収改善2005
- Author(s)
  富田幹雄, 林正弘
- Journal Title
  
  Drug Delivery System 20(4)
  
  Pages: 416-423
- Data Source
  KAKENHI-PROJECT-15590140
[Journal Article] Intestinal SGLTI-mediated absorption and metabolism on benzyl β-glucoside contained in Purunus mume : carrier- mediated transport increases intestinal availability.2005
- Author(s)
  Takashi Mizuma, Maya Nakamura, Hiroji Ina, oshio Miyazaki, Masahiro Hayashi.
- Journal Title
  
  Aiochim. Biophys. Acta. 1722
  
  Pages: 218-223
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Kinetic characterization of glycosidase activity from disaccharide conjugate to monosaccharide conjugate in Caco-2 cells2005
- Author(s)
  Takashi Mizuma, Norihiko Fuseda, Masahiro Hayashi
- Journal Title
  
  J. Pharm. Pharmacol 57
  
  Pages: 661-664
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Intestinal SGLT1-mediated absorption and metabolism of benzyl beta-glucoside contained in Prunus mume.2005
- Author(s)
  Mizuma T, Nakamura M, Ina H, Miyazaki T, Hayashi M.
- Journal Title
  
  Biochim Biophys Acta. 1722
  
  Pages: 218-223
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Differentiation of organ availability by sequential analysis and simultaneous analysis : intestinal conjugative metabolism impacts on intestinal availability in humans2005
- Author(s)
  Takashi Mizuma, Kosuke Kawashima, Shuichi Sakai, Sayaka Sakaguchi, Masahiro Hayashi
- Journal Title
  
  1. Pharm. Sci. 94
  
  Pages: 571-575
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Simultaneous HPLC assay of lenampicillin (ampicillin prodrug), ampicillin, and marker compound for high-throughput in vitro assessment of intestinal absorption and metabolism using Caco-2 cells.2005
- Author(s)
  Takashi Mizuma, Sayaka.Sakaguchi, Masahiro Hayashi.
- Journal Title
  
  J.Liq.Chromtogr.Rel.Technol. 28
  
  Pages: 1531-1537
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Does the well-stirred model assess the intestinal first-pass effect well?2004
- Author(s)
  Takashi Mizuma, Akira Tsuji, Masahiro Hayashi.
- Journal Title
  
  J Pharm Pharmacol. 56
  
  Pages: 1597-1599
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Factors affecting glucuronidation activity in Caco-2 cells.2004
- Author(s)
  Takashi Mizuma, Ryoichi Momota, Makoto Haga, Masahiro Hayashi.
- Journal Title
  
  Drug Metab Pharmacokinet. 19
  
  Pages: 130-134
- NAID
  10012923619
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Does the well-stirred model assess the intestinal first-pass effect well?2004
- Author(s)
  Mizuma T, Tsuji A, Hayashi M.
- Journal Title
  
  J Pharm Pharmacol. 56(12)
  
  Pages: 1597-1599
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Does the well-stirred model assess the intestinal first -pass effect well2004
- Author(s)
  Takashi Mizuma, Akira Tsuji, Masahiro Hayashi
- Journal Title
  
  J Pharm Pharmacol. 56
  
  Pages: 1579-1599
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Factors affecting glucuronidation activity in Caco - 2 cells.2004
- Author(s)
  Takashi Mizuma, Ryoichi Momota, Makoto Haga, Masahiro Hayashi
- Journal Title
  
  Drug Metab Pharmacokinet. 19
  
  Pages: 130-134
- NAID
  10012923619
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Factors affecting glucuronidation activity in Caco-2 cells.2004
- Author(s)
  Mizuma T, Momota R, Haga M, Hayashi M.
- Journal Title
  
  Drug Metab Pharmacokinet. 19(2)
  
  Pages: 130-134
- NAID
  10012923619
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Altered expression and function of P-glycoprotein in dextran sodium sulfate-induced colitis In m1ce2003
- Author(s)
  Hayashi Iizasa et al.
- Journal Title
  
  Journal of Pharmaceutical Sciences 92(3)
  
  Pages: 559-576
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590140
[Presentation] Enhancing mechanism of drug absorption by acylcarnitines2012
- Author(s)
  N. Doi, A. Kimura, M. Tomita and M. Hayashi
- Organizer
  International Symposium on Past, Present and Future of Molecular Pharmacokinetics
- Place of Presentation
  Hitotsubashi Hall(Tokyo, Japan)
- Year and Date
  2012-01-16
- Data Source
  KAKENHI-PROJECT-21590182
[Presentation] Acylcarnitines as useful absorption enhancer in clinical use2011
- Author(s)
  N. Doi, M. Tomita, A. Kimura and M. Hayashi
- Organizer
  International Symposium on BA/BE of Oral Drug Products
- Place of Presentation
  Kobe International conference center(Kobe, Japan)
- Year and Date
  2011-06-29
- Data Source
  KAKENHI-PROJECT-21590182
[Presentation] アシルカルニチンの吸収促進作用の腸管部位差2011
- Author(s)
  土井信幸、富田幹雄、木村あおい、林正弘
- Organizer
  日本薬剤学会第26回年会
- Place of Presentation
  タワーホール船堀(東京)
- Year and Date
  2011-05-29
- Data Source
  KAKENHI-PROJECT-21590182
[Presentation] アシルカルニチンによるTight JunctionおよびABCトランスポーター機能変化における濃度依存性と寄与率の変動2011
- Author(s)
  木村あおい、富田幹雄、土井信幸、新井友里、吉田未紀、林正弘
- Organizer
  日本薬剤学会第26回年会
- Place of Presentation
  タワーホール船堀(東京)
- Year and Date
  2011-05-29
- Data Source
  KAKENHI-PROJECT-21590182
[Presentation] 腸管におけるアシルカルニチンの吸収促進剤としての有用性と安全性2011
- Author(s)
  土井信幸、富田幹雄、木村あおい、林正弘
- Organizer
  日本薬物動態学会第26回年会
- Place of Presentation
  広島国際会議場(広島)
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-21590182
[Presentation] Lipopolysaccharide誘発感染症時における薬物体内動態に関する末梢血リンパ球に基づく予測2008
- Author(s)
  畑中恵, 富田幹雄, 中池万里子, 林正弘
- Organizer
  医療薬学フォーム2008/第16回クリニカルフアーマシーシンポジウウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18590156
[Presentation] Prediction of intestinal drug absorption and hepatic disposition by non-invasive method using peripheral blood lymphocyte2007
- Author(s)
  M. Nakaike, M. Tomita, M. Hayashi
- Organizer
  22nd JSSX/8th International ISSX Meeting
- Place of Presentation
  Sendai, Japan
- Data Source
  KAKENHI-PROJECT-18590156
[Presentation] Prediction of intestinal drug absorption and disposition by non-invasive method using peripheral blood lymphocyte2007
- Author(s)
  M. Nakaike, M. Tomita, M. Hayashi
- Organizer
  4th World Conference on Drug Absorption, Trans-port and Delivery
- Place of Presentation
  Kanazawa, Japan
- Data Source
  KAKENHI-PROJECT-18590156

1. AWAZU Shoji (60012621)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. HORIE Toshiharu (90120154)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. TOMITA Mikio (60207610)

# of Collaborated Projects: 5 results

# of Collaborated Products: 26 results
4. HAGA Makoto (70110666)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. MIZUMA Takashi (80229715)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
6. OKUDAIRA Kazuho (30204134)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KAIHO Fusao (10120180)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HANANO Manabu (60012598)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. YATA Noboru (70028835)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TUJI Akira (10019664)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SUGIYAMA Yuichi (80090471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. CHIBA Kan (40159033)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. ISHIZAKI Takashi (50158747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 柳樂眞友子 (10349821)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. HOSOI Kaoru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HAYASHI Masahiro 林 正弘

Research Projects

Research Products

Co-Researchers

Improvement of inflammatory bowel diseases based on expression and functional changes of P-glycoprotein by methylpredonislone and essential fatty acidsPrincipal Investigator

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New Prediction System of Infective Disease Based on Changes in Expression and Function of ABC TransporterPrincipal Investigator

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Improvement of intestinal drug absorption based on structural changes of tight junction and functional changes of P-glycoproteinPrincipal Investigator

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Intestinal Drug Absorption and Excretion-Detoxication Using Regulation of Membrane Permeation by Oligopeptide-produced NeutrophilsPrincipal Investigator

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Development of in vitro screening system for CYP based drug interactionPrincipal Investigator

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Physiological and Biochemical Assessment of Membrane Barrier Function in Inflammatory DiseasePrincipal Investigator

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HAYASHI Masahiro 林正弘

[Book] 医薬品トキシコロジー改訂版第3版2006