MEKADA Eisuke 目加田英輔

… Alternative Names

目加田英輔メカダエイスケ

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Researcher Number	20135742
Other IDs
Affiliation (Current)	2025: 滋慶医療科学大学, 医療管理学研究科, 客員教授
Affiliation (based on the past Project Information) *help	2016: 大阪大学, 微生物病研究所, 招聘教授 1999 – 2016: 大阪大学, 微生物病研究所, 教授 1991 – 2000: Institute of Life Science, Kurume University Professor, 分子生命科学研究所, 教授 1999: 久留米大学, 分子生命研, 教授 1995: 久留目大学, 分子生命科学研究所, 教授 1988: Kurume University, 分子生命科学研究所, 教授 1986 – 1987: 大阪大学, 細胞工学センター, 助手
Review Section/Research Field	Principal Investigator Cell biology / Biological Sciences / Cell biology / Bacteriology (including Mycology) / 細菌学 / Tumor therapeutics / Tumor biology / Bacteriology (including Mycology) Except Principal Investigator Cell biology / 医学一般 … More / Obstetrics and gynecology / Dermatology / Pediatrics / Functional biochemistry / Structural biochemistry / Bacteriology (including Mycology) Less
Keywords	Principal Investigator HB-EGF / CD9 / ジフテリア毒素 / インテグリン / DRAP27 / 膜結合型細胞増殖因子 / ジャクスタクライン / 細胞増殖因子 / 細胞接着 / リセプター … More / TM4ファミリー / エンドサイトーシス / エクトドメインシェディング / LPA / CRM197 / ヘパラン硫酸プロテオグリカン / ジフテリア毒素リセプター / Diphtheria toxin / 色素性乾皮症 / EGFファミリー / G蛋白共役型リセプター / トランスアクチベーション / 増殖因子 / アポトーシス / 膜通過 / ectodomain shedding / ADAM / RNAi / Ectodomain shedding / Transactivation / メタロプロテアーゼ / リゾフォスファチジン酸 / MAPキナーゼキナーゼ / プロテインキナーゼC / GFP / 膜結合型 / Growth Factors / Cell adhesion / Integrin / diphtheria toxin / membrane-anchored growth factors / TM4 / integrin / juxtacrine / Fusion protein / Endonuclease / Xeroderma pigmentosum / フラグメントB / EGFリセプター / EGF受容体 / 増殖抑制 / siRNA / EGFR / 遺伝子ターゲッティング / CD63 / 細胞外マトリックス / 複合体 / 発現クローニング / マイコプラズマ / ErbB4 / Monoclonal Antibody / Receptor / エンドサイドーシス / モノクローナル抗体 / DNA aray / SiRNA / レンチウィルス / シェディング / DNAアレイ / protease / シグナル伝達 / プロテアーゼ / エクトドメインシェディン / ovarian cancer / growth factor / EGF family / 心不全 / p38MAPK / 遺伝子欠損マウス / 卵巣癌 / complex / epidermis / fertilization / C. elegans / membrane fusion / ノックアウトマウス / テトラスパニン / 膜4回貫通型 / 表皮 / 線虫 / 受精 / 膜融合 / G-protein-coupled receptor / メタロプロデアーゼ / G-oritein-coupled receptors / エクトドメインシェヂング / recombinant proteins / anthrax toxin / 蛋白質導入 / 蛋白質導入法 / 炭疽毒素 / heregulin / EGF receptor / 腫瘍増殖因子抑制物質 / heparansulfate proteoglycans / TPA / haparansulfate proteoglycans / FuragmentB / 融合蛋白 / エンドヌクレアーゼ / Genetic disorder / 融合蛋白質 / 遺伝子発現 / 遺伝病 / エンドヌクレア-ゼ / ＥＧＦ受容体 / ＨＢ-ＥＧＦ / 心臓弁 / コレステロール / ジフラリア毒素 / 綱羅的遺伝子同定法 / 宿主側因子 / 網羅的遺伝子同定法 / 宿主因子 / shRNA / 増殖機構 / 3次元環境 / 癌間質 / sHRNA / 腫瘍形成 / EGF / 3次元増殖 / neuregulin / カドヘリン / カテニン / 浸潤転移 / エミリン / 細胞間接着部位 / 細胞内局在 / ジャクスタクランイ機構 / プロテオグリカン / theta毒素 / V-ATPase / エンドソーム / バフィロマイシン / H^+-ATPase / 酸性化 / cDNAクロ-ニング / 膜タンパク質 / リセプタ- … More Except Principal Investigator HB-EGF / インテグリン / 細胞接着 / ラミニン / 細胞外マトリックス / LPA / 膜結合型増殖因子 / 癌 / Tumor Growth / ADAM Family / Transactivation / EGFR / Ovarian Cancer / AHNAK / シグナル伝達 / レトロウイルスベクター / アデノウイルスベクター / キメラベクター / 遺伝子治療 / ジャクスタクライン / EGF受容体 / CD9 / フィブロネクチン / 細胞外基質 / 転移 / 増殖 / 活性酸素種（ROS） / 線虫 / Dual Oxidase（DUOX） / 活性酸素種 / 寿命 / 活性酸素（ROS） / Dual oxidase（Duox） / TSP-15 / ピロロキノリンキノン（PQQ） / 活性酸素種（ROS) / Dual oxidase / テトラスパニン / Erythrocyte membranes / Lipsomes with gangliosides / Introduction of DNA and proteins into cells / 疾病細胞 / 細胞内注入 / 巨大高分子 / 活性ペプチド / 細胞内導入 / 高分子物質 / EF2の構造と機能 / 赤血球膜 / ガングリオシドも持ったリポソーム / DNAと蛋白質の細胞への注入 / EGFRリガンド / molecular biclogy / Cell adhesion / BS cell / Keratinocyte / Desincykin / Knockoit mouse / Desmosome / エンボプラキン / デスモグレイン / デスモヨーキンケラチノサイト / 細胞膜 / 核移行 / デスモソーム / 癌抑制遺伝子 / ノックアウトマウス / デスモヨーキン / 細胞内情報伝達 / ケラチノサイト / 表皮 / Gene transduction / Adenovirus / Hepatocyte growth factor / Retrovirus / Liver / Chimeric vector / Gene therapy / Metabolic disease / 肝遺伝子導入法 / HGF / アデノウイルス / レトロウイルス / 遺伝子導入 / 肝細胞増殖因子 / 肝 / 先天代謝疾患 / TRANSMEMBRANE 4 SUPERFAMILY / CYTOSKELETON / CELL ADHESION / INTEGRIN / LAMININ / BASEMENT MEMBRANE / TM4SF / 基底膜 / Membrane-bound Cell Growth Factor / Laminin / Smooth Moscle Cells / Cadherin / PAxillin / Cell Adhesion / Extracellular Matrix / Integrin / Rho / 細胞内骨格系 / 平滑筋細胞 / カドヘリン / パキシリン / 細胞骨格 / 細胞増殖 / 増殖因子 / Ectodomain shedding / 浸潤 / コンビネーション遺伝子治療 / protein kinase C / MDC9 / インテグリンα3β1 / DRAP27 / ジフテリア毒素リセプター / ジフテリア毒素 Less

Development of a novel anti-cancer therapeutics targeting HB-EGFPrincipal Investigator
- Principal Investigator
  
  MEKADA EISUKE
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Osaka University
Investigation of molecular roles of tetraspanin in dual oxidase activaiton
- Principal Investigator
  
  MORIBE Hiroki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Kurume University
The role of HB-EGF in cancer cell proliferation and malignancyPrincipal Investigator
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Tumor biology
- Research Institution
  Osaka University
Integration and regulatory mechanism for growth factor and cell adhesion signals
- Principal Investigator
  
  MIZUSHIMA Hiroto
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Osaka University
Identification of host cell factors involved in diphtheria toxin sensitivity by using shRNA library.Principal Investigator
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Osaka University
Identification of genes involved in the ectodomain sheddingof HB-EGFPrincipal Investigator
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  Osaka University
Cell function regulation by membrane-anchored growth factorsPrincipal Investigator
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Analysis of the ectodomain shedding mechanism of HB-EGFPrincipal Investigator
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Cell biology
- Research Institution
  Osaka University
Biological Significance of HB-EGF Expression at Cell-Cell Contact Sites in Progression of Ovarian Cancer
- Principal Investigator
  
  MIYAMOTO Shingo
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Fukuoka University
  Kyushu University
Growth regulation mediated by EGF family of growth factorsPrincipal Investigator
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
膜結合型増殖因子と細胞間接着因子による細胞増殖および浸潤制御Principal Investigator
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Analysis of the function of CD9 and tetraspaninsPrincipal Investigator
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  Osaka University
膜結合型増殖因子proHB-EGFによるEGF受容体を介した情報伝達機構の解析
- Principal Investigator
  
  岩本亮
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kurume University
Development of knockout mouse of desmoyokin(AHNAK)and analysis of its functio
- Principal Investigator
  
  MORI Osamu
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Kurume University School of Medicine(Department of Dermatology)
The role and molecular mechanism of the ectodomain shedding of HB-EGFPrincipal Investigator
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Cell biology
- Research Institution
  Osaka University
  Kurume University
Conversion of membrane-anchored HB-EGF into the soluble form.Principal Investigator
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Cell biology
- Research Institution
  Osaka University
膜結合型増殖因子複合体によるジャクスタクライン機構の解析
- Principal Investigator
  
  岩本亮
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kurume University
新しいキメラベクターとコンビネーション癌遺伝子治療法の開発
- Principal Investigator
  
  KOSAI Ken-ichiro
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kurume University
SIGNAL TRANSDUCTION BY INTEGRIN-MATRIX INTERACTION
- Principal Investigator
  
  SEKIGUCHI Kiyotoshi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Functional biochemistry
- Research Institution
  Osaka University
Development of novel chimeric vector and hepatic gene therapy
- Principal Investigator
  
  KOSAI Ken-ichiro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
膜結合型細胞増殖因子による細胞接着を介した細胞増殖制御Principal Investigator
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
The role of membrane-anchored HB-EGF on cell growthPrincipal Investigator
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Cell biology
- Research Institution
  Kurume University
Juxtacrine Growth Control with HB-EGF ComplexPrincipal Investigator
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  Kurume University
Introduction of exogenous proteins into nucleus by using anthrax toxinPrincipal Investigator
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Institute of Life Science, Kurume University
膜結合型細胞増殖因子と細胞外マトリックスの相互作用によるシグナルの伝達Principal Investigator
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
癌細胞の増殖と転移を支える細胞外基質/インテグリン系の解析とその応用
- Principal Investigator
  
  宮崎香
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Yokohama City University
CD9ファミリーを介した膜結合型細胞増殖因子-細胞接着因子複合体の機能解析Principal Investigator
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
ジフテリア毒素リセプター複合体の解析
- Principal Investigator
  
  岩本亮
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kurume University
膜結合型細胞増殖因子と細胞外マトリックスの相互作用によるシグナルの伝達Principal Investigator
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
癌細胞の増殖と転移を支える細胞外基質/インテグリン系の解析とその応用
- Principal Investigator
  
  MIYAZAKI Kaoru
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Yokohama City University
膜タンパク質DRAP27を介した膜結合型細胞増殖因子と細胞接着因子のクロスリンクPrincipal Investigator
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
Role of Integrin-mediated Signal Transduction in Cell Growth and Differentiation
- Principal Investigator
  
  SEKIGUCHI Kiyotoshi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  Research Institute, Osaka Medical Center for Maternal and Child Health
Analysis of the comprising membrane-anchored growth factor and cell adhesion molecule.Principal Investigator
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  Kurume University
An attempt to form mutant CRM197 proteins of diphtheria toxin with neutralizing activity to heregulin.Principal Investigator
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kurume University
ジフテリア毒素のエンドソーム膜通過機構の解析Principal Investigator
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
膜結合型細胞増殖因子と細胞外マトリックスの相互作用によるシグナルの伝達Principal Investigator
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
膜タンパク質DRAP27を介した膜結合型細胞増殖因子と細胞接着因子のクロスリングPrincipal Investigator
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
膜結合型細胞増殖因子を介したジャクスタクラインにおけるDRAP27の機能解析Principal Investigator
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Kurume University
Juxtacrine stimulation of cellular communication by HB-EGF.Principal Investigator
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kurume University
ジフテリア毒素のエンドサイトーシス過程におけるDRAP27タンパク質の役割解析Principal Investigator
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
細胞内酸性小胞からの毒素タンパク質の細胞内遊離機構の解析Principal Investigator
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
膜結合型細胞増殖因子と細胞外マトリックスの相互作用によるシグナルの伝達Principal Investigator
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
膜結合型細胞増殖因子HB-EGFの細胞膜上での発現を調節すタンパク質の解析Principal Investigator
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Kurume University
ジフテリア毒素をモデルにした蛋白質の細胞内輸送機構の解析Principal Investigator
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
バフィロンマイシンによるジフテリア毒素の細胞内輸送・分解機構の解析Principal Investigator
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
膜蛋白質DRAP27のジフテリア毒素受容体および毒素の細胞内侵入における役割Principal Investigator
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  細菌学
- Research Institution
  Kurume University
Sending regulatory elements into the nuclei from medium.Principal Investigator
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kurume University
ジフテリア毒素をモデルにした蛋白質の細胞内輸送機構の解析Principal Investigator
- Principal Investigator
  
  目加田英輔
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kurume University
Sending regulatory elements into the nuelei of cells.Principal Investigator
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kurume University
Analysis of diphtheria toxin receptor by molecular cloning.Principal Investigator
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  細菌学
- Research Institution
  Kurume University
  Osaka University
Basic studies on treatment of abnormal cells by introduction of active macromolecules into cells.
- Principal Investigator
  
  UCHIDA Tsuyoshi
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  医学一般
- Research Institution
  Osaka University

[Book] M.R. Academic Press2006
- Author(s)
  Horiguchi,Y. Mekada,E
- Publisher
  Toxin receptors in The comprehensive Sourcebook of Bacterial Protein Toxins, ed by Alouf, J.E. and Popoff
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] BK-UM in patients with recurrent ovarian cancer or peritoneal cancer: a first-in-human phase-I study.2017
- Author(s)
  Miyamoto S, Yotsumoto F,他３０名、 Iwamoto R, Mekada E.
- Journal Title
  
  BMC Cancer.
  
  Volume: 17 Issue: 1 Pages: 89-97
- DOI
  10.1186/s12885-017-3071-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26250033, KAKENHI-PROJECT-26293362, KAKENHI-PROJECT-15K07046
[Journal Article] ErbB1 and ErbB4 generate opposing signals regulating mesenchymal cell proliferation during valvulogenesis.2017
- Author(s)
  Iwamoto R, Mine N, Mizushima H, Mekada E
- Journal Title
  
  J Cell Sci.
  
  Volume: 130 Issue: 7 Pages: 1321-1332
- DOI
  10.1242/jcs.196618
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26250033, KAKENHI-PROJECT-15K07046
[Journal Article] Reconstitution of a metastatic-resistant tumor microenvironment with cancer-associated fibroblasts enables metastasis.2017
- Author(s)
  Murata T, Mekada E, Hoffman RM.
- Journal Title
  
  Cell Cycle.
  
  Volume: 16 Issue: 6 Pages: 533-535
- DOI
  10.1080/15384101.2017.1281486
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26250033, KAKENHI-PROJECT-26462542
[Journal Article] Characterization of a novel anti-human HB-EGF monoclonal antibody applicable for paraffin-embedded tissues and diagnosis of HB-EGF-related cancers.2016
- Author(s)
  Iwamoto,R., Takagi, M., Akatsuka, J., Ono, K., Kishi, Y., and Mekada, E.
- Journal Title
  
  Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
  
  Volume: 35 Issue: 2 Pages: 1-10
- DOI
  10.1089/mab.2015.0062
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07046, KAKENHI-PROJECT-24570212, KAKENHI-PROJECT-26250033
[Journal Article] Identification of diphtheria toxin R domain mutants with enhanced inhibitory activity against HB-EGF2015
- Author(s)
  Suzuki K, Mizushima H, Abe H, Iwamoto R, Nakamura H, Mekada E
- Journal Title
  
  J Biochem
  
  Volume: mvu079 Issue: 5 Pages: 331-343
- DOI
  10.1093/jb/mvu079
- NAID
  40020461422
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23570227, KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118008, KAKENHI-PROJECT-26460525, KAKENHI-PROJECT-15K07046, KAKENHI-PROJECT-24570212, KAKENHI-PROJECT-26250033
[Journal Article] Antibody-modified lipid nanoparticles for selective delivery of siRNA to tumors expressing membrane-anchored form of HB-EGF.2014
- Author(s)
  Okamoto A, Asai T, Kato H, Shimizu K, Ando H, Minamino T, Mekada E, Oku N
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 449 Issue: 4 Pages: 460-465
- DOI
  10.1016/j.bbrc.2014.05.043
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460041, KAKENHI-PROJECT-26250033
[Journal Article] Metastasis Suppressor Tetraspanin CD82/KAI1 Regulates Ubiquitylation of Epidermal Growth Factor Receptor.2013
- Author(s)
  Odintsova E, van Niel G, Conjeaud H, Raposo G, Iwamoto R, Mekada E, Berditchevski F.
- Journal Title
  
  J Biol Chem.
  
  Volume: 288 Issue: 36 Pages: 26323-26334
- DOI
  10.1074/jbc.m112.439380
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23240126, KAKENHI-PROJECT-24570212
[Journal Article] Co-occurrence of tetraspanin and ROS generators: Conservation in protein cross-linking and other developmental processes.2013
- Author(s)
  Moribe H, Mekada E.
- Journal Title
  
  Worm
  
  Volume: 2 Issue: 2 Pages: 23415-23416
- DOI
  10.4161/worm.23415
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23240126
[Journal Article] Conditional loss of heparin-binding EGF-like growth factor results in enhanced liver fibrosis after bile duct ligation in mice.2013
- Author(s)
  Takemura T, Yoshida Y, Kiso S, Kizu T, Furuta K, Ezaki H, Hamano M, Egawa M, Chatani N, Kamada Y, Imai Y, Higashiyama S, Iwamoto R, Mekada E, Takehara T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 437 Issue: 2 Pages: 185-191
- DOI
  10.1016/j.bbrc.2013.05.097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240126, KAKENHI-PROJECT-23590974, KAKENHI-PROJECT-24390074, KAKENHI-PROJECT-24570212, KAKENHI-PROJECT-24590972, KAKENHI-PROJECT-24590975
[Journal Article] Development of anti-HB-EGFimmunoliposomes for the treatment ofbreast cancer2012
- Author(s)
  Nishikawa K, Asai T, Shigematsu H, Shimizu K, Kato H, Asano Y, Takashima S, Mekada E, Oku N, Minamino T.
- Journal Title
  
  J Control Release
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] Tetraspanin is required for generation of reactive oxygen species by the dual oxidase system in Caenorhabditis elegans.2012
- Author(s)
  Moribe, H., Konakawa, R., Yoneda, T., Koga, D., Ushiki, T., Nakamura K. and Mekada, E.
- Journal Title
  
  PLoS Genet.
  
  Volume: 8 Issue: 9 Pages: e1002957-e1002957
- DOI
  10.1371/journal.pgen.1002957
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240126
[Journal Article] Development of anti-HB-EGF immunoliposomes for the treatment of breast cancer2012
- Author(s)
  Nishikawa K, Asai T, Mekada E, 他7名
- Journal Title
  
  J Control Release
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] Soluble heparin-binding EGF-like growth factor (HB-EGF) detected by newly developed immuno-PCR method is a clear-cut serological biomarker for ovarian cancer.2012
- Author(s)
  Kasai N, Kobayashi K, Shioya S, Yoshikawa Y, Yotsumoto F, Miyamoto S, Mekada E, Enokizono J.
- Journal Title
  
  Am J Transl Res.
  
  Volume: 4 Pages: 415-421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240126
[Journal Article] MIG-13 controls anteroposterior cell migration by interacting with UNC-71/ADM-1 and SRC-1 in Caenorhabditis elegans2012
- Author(s)
  Masuda H, Nakamura, Takata N, Itoh B, Hirose T, Moribe H, Mekada E, Okada M
- Journal Title
  
  FEBS Lett 2012
  
  Volume: 586(6) Issue: 6 Pages: 740-6
- DOI
  10.1016/j.febslet.2012.01.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240088, KAKENHI-PROJECT-23240126
[Journal Article] MIG-13 controls anteroposterior cell migration by interacting with UNC-71/ADM-1 and SRC-1 in caenorhabditis elegans2012
- Author(s)
  Masuda H, Nakamura K, Mekada E, 他5名
- Journal Title
  
  FEBS Letters
  
  Volume: 586 Pages: 740-746
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] Development of anti-HB-EGF immunoliposomes for the treatment of breast cancer.2012
- Author(s)
  K. Nishikawa, T. Asai, H. Shigematsu, K. Shimizu, H. Kato, Y. Asano, S. Takashima, E. Mekada, N. Oku, T. Minamino
- Journal Title
  
  J. Control. Release
  
  Volume: 160 Issue: 2 Pages: 274-280
- DOI
  10.1016/j.jconrel.2011.10.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790045, KAKENHI-PROJECT-22890104, KAKENHI-PROJECT-23240126, KAKENHI-PROJECT-23659416, KAKENHI-PROJECT-24591096, KAKENHI-PROJECT-24790047
[Journal Article] MIG-13 controls anteroposterior cellmigration by interacting withUNC-71/ ADM-1 and SRC-1 incaenorhabditis elegans2012
- Author(s)
  Masuda H, Nakamura K, Takata N, Ito B, Hirose T, Moribe H, Mekada E, Okada M
- Journal Title
  
  FEBS Letters
  
  Volume: 586 Pages: 740-746
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] Conditional knockout of heparin-binding epidermal growth factor-like growth factor in the liver accelerates carbon tetrachloride-induced liver injury in mice.2012
- Author(s)
  Takemura, T., YoshidaY., Kiso, S., Saji, Y., Ezaki, H., Hamano, M., Kizu, T., Egawa, M., Chatani, N., Furuta, K., Kamada, Y., Iwamoto, R., Mekada, E., Higashiyama, S., Hayashi, N. and Takehara, T.
- Journal Title
  
  Hepatol Res
  
  Volume: 43 Issue: 4 Pages: 384-393
- DOI
  10.1111/j.1872-034x.2012.01074.x
- NAID
  10031194550
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240126, KAKENHI-PROJECT-23590974, KAKENHI-PROJECT-24570212, KAKENHI-PROJECT-24590972
[Journal Article] HB-EGF and PDGF mediate reciprocalinteractions of carcinoma cells withcancer-associated fibroblasts tosupport progression of uterine cervicalcancers2011
- Author(s)
  Murata T, Mizushima H, Chinen I, Moribe H, Yagi S, Hoffman RM, Kimura T, Yoshino K, Ueda Y, Enomoto T, Mekada E
- Journal Title
  
  Cancer Research
  
  Volume: 71 Pages: 6633-6642
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] A Novel Anti-Human HB-EGF Monoclonal Antibody with Multiple Antitumor Mechanisms against Ovarian Cancer Cells2011
- Author(s)
  Miyamoto S, Iwamoto R, Mekada E, 他11名
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 17 Pages: 6733-6741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] Proteolytic activation of heparin-binding EGF-like growth factor by membrane-type matrix metlloproteinase-1 in ovarian carcinoma cells2011
- Author(s)
  Koshikawa N, Mizushima H, Mekada E, 他6名
- Journal Title
  
  Cancer Science
  
  Volume: 102 Pages: 111-116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] Assessment of HB-EGF levels in peritoneal fluid and serum of ovarian cancer patients using ELISA2011
- Author(s)
  Hikita S, Yotsumoto F, Mekada E, 他14名
- Journal Title
  
  Anticancer Research
  
  Volume: 31 Pages: 2553-2559
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] HB-EGF and PDGF Mediate Reciprocal Interactions of Carcinoma Cells with Cancer-Associated Fibroblasts to Support Progression of Uterine Cervical Cancers2011
- Author(s)
  Murata T, Mizushima H, Mekada E, 他8名
- Journal Title
  
  Cancer Research
  
  Volume: 71 Pages: 6633-6642
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] HB-EGF and PDGF mediate reciprocal interactions of carcinoma cells with cancer-associated fibroblasts to support progression of uterine cervical cancers2011
- Author(s)
  Murata T, Mizushima H, Chinen I, Moribe H, Yagi S, Hoffman RM, Kimura T, Yoshino K, Ueda Y, Enomoto T, Mekada E.
- Journal Title
  
  Cancer Res.
  
  Volume: 71 (21) Pages: 6633-6642
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570227
[Journal Article] Proteolytic activation of heparinbinding EGF-like growth factor bymembrane-type matrix metalloproteinase-1 in ovarian carcinoma cells2011
- Author(s)
  Koshikawa N, Mizushima H, Minegishi T, Eguchi F, Yotsumoto F, Nabeshima K, Miyamoto S, Mekada E, Seiki M.
- Journal Title
  
  Cancer Science
  
  Volume: 102 Pages: 111-116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] A novelanti-human HB-EGF monoclonal antibodywith multiple antitumor mechanismsagainst ovarian cancer cells.2011
- Author(s)
  Miyamoto S, Iwamoto R, Furuya A, Takahashi K, Sasaki Y, Ando H, YotsumotoF, Yoneda T, Hamaoka M, Yagi H, MurakamiT, Hori S, Shitara K, Mekada E
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 17 Pages: 6733-6741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] Proteolytic activation of heparin-binding EGF-like growth factor by membrane-type matrix metalloproteinase-1 in ovarian carcinoma cells.2011
- Author(s)
  Koshikawa,N., Mizushima,H., Minegishi,T., Eguchi,F., Yotsumoto,F., Nabeshima,K. Miyamoto,S., Mekada,E., Seiki,M
- Journal Title
  
  Cancer Sci. 102
  
  Pages: 111-116
- NAID
  10029288679
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Assessment ofHB-EGF levels in peritoneal fluid andserum of ovarian cancer patients usingELISA2011
- Author(s)
  Hikita S, Yotsumoto F, Fukami T, Horiuchi S, Sanui A, Miyata K, Nam SO, Tsujioka H, Ueda T, Shirota K, YoshizatoT, Maeda K, Ishikawa T, Okuno Y, Kuroki M, Mekada E, Miyamoto S
- Journal Title
  
  Anticancer Res
  
  Volume: 31 Pages: 2553-2559
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] Anti-human HB-EGF monoclonal antibodies inhibiting ectodomain shedding of HB-EGF and diphtheria toxin binding.2010
- Author(s)
  Hamaoka, M., Chinen, I., Murata, T., Takashima, S., Iwamoto, R., Mekada, E.
- Journal Title
  
  J.Biochem.
  
  Volume: 148 Pages: 55-69
- NAID
  10027877136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] HB-EGF function in cardiac valve development requires interaction with heparan sulfate proteoglycans.2010
- Author(s)
  Iwamoto,R., Mine,N., Kawaguchi,T., Minami,S., Saeki,K., Mekada,E.
- Journal Title
  
  Development 137
  
  Pages: 2205-2214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Anti-human HB-EGF monoclonal antibodies inhibiting ectodomain shedding of HB-EGF and diphtheria toxin binding.2010
- Author(s)
  Hamaoka,M., Chinen,I., Murata,T., Takashima,S., Iwamoto,R., Mekada,E.
- Journal Title
  
  J. Biochem. 148
  
  Pages: 55-69
- NAID
  10027877136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Anti-human HB-EGF monoclonal antibodies inhibiting ectodomain shedding of HB-EGF and diphtheria toxin binding.2010
- Author(s)
  Hamaoka M, Chinen I, Murata T, Takashima S, Iwamoto R, Mekada E
- Journal Title
  
  J. Biochem
  
  Volume: 148 Pages: 55-69
- NAID
  10027877136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] Humanized Gene Replacement in Mice Reveals the Contribution of Cancer Stroma-Derived HB-EGF to Tumor Growth.2010
- Author(s)
  Ichise T, Adachi S, Ohishi M, Ikawa M, Okabe M, Iwamoto R, Mekada E.
- Journal Title
  
  Cell Struct Funct.
  
  Volume: 35 Pages: 3-13
- NAID
  130004137552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Humanized Gene Replacement in Mice Reveals the Contribution of Cancer Stroma-Derived HB-EGF to Tumor Growth.2010
- Author(s)
  Ichise,T., Adachi,S., Ohishi,M., Ikawa,M., Okabe,M., Iwamoto,R., Mekada,E.
- Journal Title
  
  Cell Struct Funct. 35
  
  Pages: 3-13
- NAID
  130004137552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] MT1-MMP cleaves off the NH2-terminal portion of HB-EGF and converts it into a heparin-independent growth factor2010
- Author(s)
  Koshikawa N, Mizushima H, Minegishi T, Iwamoto R, Mekada E, Seiki M
- Journal Title
  
  Cancer Res
  
  Volume: 70 Pages: 6093-6103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] Humanizad Gene Replacement in Mice Reveals the Contribution of Cancer Stroma-Derived HB-EGF to Tumor Growth.2010
- Author(s)
  Ichise T, Adachi S, Ohishi M, Ikawa M, Okabe M, Iwamoto R, Mekada E.
- Journal Title
  
  Cell Struct Funct.
  
  Volume: 35 Pages: 3-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] MT1-MMP cleaves off the NH2-terminal portion of HB-EGF and converts it into a heparin -independent growth factor.2010
- Author(s)
  Koshikawa,N., Mizushima,H., Minegishi,T., Iwamoto,R., Mekada,E. Seiki,M
- Journal Title
  
  Cancer Res. 70
  
  Pages: 6093-6103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] HB-EGF function incardiac valve development requires interaction with heparan sulfate proteoglycans2010
- Author(s)
  Iwamoto R, Mine N, Kawaguchi T, MinamiS, Saeki K, Mekada E.
- Journal Title
  
  Development
  
  Volume: 137 Pages: 2205-2214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] HB-EGF function in cardiac valve development requires interaction with heparan sulfate proteoglycans2010
- Author(s)
  Iwamoto R, Mine N, Mekada E, 他3名
- Journal Title
  
  Development
  
  Volume: 137 Pages: 2205-2214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] Anti-human HB-EGF monoclonal antibodies inhibiting ectodomain shedding of HB-EGF and diphtheria toxin binding2010
- Author(s)
  Hamaoka M, Chinen I, Mekada E, 他3名
- Journal Title
  
  J.Biochem.
  
  Volume: 148 Pages: 55-69
- NAID
  10027877136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] Humanized Gene Replacement in Mice Reveals the Contribution of Cancer Stroma-Derived HB-EGF to Tumor Growth.2010
- Author(s)
  Ichise T, Adachi S, Ohishi M, Ikawa M, Okabe M, Iwamoto R, Mekada E.
- Journal Title
  
  Cell Struct Funct. 35
  
  Pages: 3-13
- NAID
  130004137552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] HumanizedGene Replacement in Mice Reveals theContribution of Cancer Stroma-DerivedHB-EGF to Tumor Growth2010
- Author(s)
  Ichise T, Adachi S, Ohishi M, Ikawa M, Okabe M, Iwamoto R, Mekada E
- Journal Title
  
  Cell StructFunct
  
  Volume: 35 Pages: 3-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] Synergistic antitumor effect ofpaclitaxel with CRM197, an inhibitor of HB-EGF, in ovarian cancer2009
- Author(s)
  Yagi H, Yotsumoto F, Sonoda K, Kuroki M, Mekada E, Miyamoto S
- Journal Title
  
  Int J Cancer
  
  Volume: 124 Pages: 1429-1439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] Integrin signal masks growth-promotion activity of HB-EGF in monolayer cell cultures.2009
- Author(s)
  Mizushima, H., Wang, X., Miyamoto, S., Mekada, E.
- Journal Title
  
  J.Cell Sci. 122
  
  Pages: 4277-4286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Synergistic antitumor effect of paclitaxel with CRM197, an inhibitor of HB-EGF, in ovarian cancer.2009
- Author(s)
  Yagi H, Yotsumoto F, Sonoda K, Kuroki M, Mekada E, Miyamoto S
- Journal Title
  
  Int J Cancer
  
  Volume: 124 Pages: 1429-1439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] Integrin signal masks growth-promotion activity of HB-EGF in monolayer cell cultures.2009
- Author(s)
  Mizushima,H., Wang,X., Miyamoto,S., Mekada,E.
- Journal Title
  
  J. Cell Sci. 122
  
  Pages: 4277-4286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Synergistic antitumor effect of paclitaxel with CRM197, an inhibitor of HB-EGF, in ovarian cancer.2009
- Author(s)
  Yagi,H., Yotsumoto,F., Sonoda,K., Kuroki,M., Mekada,E., Miyamoto,S
- Journal Title
  
  Int J Cancer 124
  
  Pages: 1429-1439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Synergistic antitumor effect of paclitaxel with CRM197, an inhibitor of HB-EGF, in ovarian cancer.2009
- Author(s)
  Yagi H, Yotsumoto F, Sonoda K, Kuroki M, Mekada E, Miyamoto S.
- Journal Title
  
  Int J Cancer
  
  Volume: 124 Pages: 1429-1439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Synergistic antitumor effect of paclitaxel with CRM197, an in hibitor of HB-EGF, in ovarian cancer.2009
- Author(s)
  Yagi H, Yotsumoto F, Sonoda K, Kuroki M, Mekada E, Miyamoto S.
- Journal Title
  
  Int J Cancer 124
  
  Pages: 1429-1439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Integrin signal masks growth-promotion activity of HB-EGF in monolayer cell cultures.2009
- Author(s)
  Mizushima, H., Wang, X., Miyamoto, S., Mekada, E.
- Journal Title
  
  J Cell Sci.
  
  Volume: 122 Pages: 4277-4286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] Integrin signal masksgrowth-promotion activity of HB-EGF inmonolayer cell cultures.2009
- Author(s)
  Mizushima H, Wang X, Miyamoto S, Mekada E.
- Journal Title
  
  J. Cell Sci
  
  Volume: 122 Pages: 4277-4286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] Integrin signal masks growth-promotion activity of HB-EGF in monolayer cell cultures.2009
- Author(s)
  Mizushima, H., Wang, X., Miyamoto, S., Mekada, E.
- Journal Title
  
  J.Cell Sci.
  
  Volume: 122 Pages: 4277-4286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] HB-EGF decelerates cell proliferation synergistically with TGF-a in perinataldistal lung development2008
- Author(s)
  Minami S, Iwamoto R, Mekada E.
- Journal Title
  
  Dev. Dyn
  
  Volume: 237 Pages: 247-258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] Double deficiency of tetraspanins CD9 and CD81 alters cell motility and protease production of macrophages and causes COPD-1ike phenotype in mice.2008
- Author(s)
  Takeda Y, He P, Tachibana I, Mekada, E, 他12名
- Journal Title
  
  J Biol Chem. 283
  
  Pages: 26089-26097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] Thefusing ability of sperm is bestowed byCD9-containing vesicles released fromeggs in mice2008
- Author(s)
  Miyado K, Yoshida K, Yamagata K, Sakakibara K, Okabe M, Wang X, MiyamotoK, Akutsu H, Kondo T, Takahashi Y, BanT, Ito C, Toshimori K, Nakamura A, ItoM, Miyado M, Mekada E, Umezawa A
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 105 Pages: 12921-12926
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] HB-EGF decelerates cell proliferation synergistically with TGF-・in perinatal distal lung development.2008
- Author(s)
  Minami, S., Iwamoto, R., Mekada, E.
- Journal Title
  
  Dev.Dyn. 237
  
  Pages: 247-258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Possible involvement of CD81 in acrosome reaction of sperm inmice2008
- Author(s)
  Tanigawa M, Miyamoto K, KobayashiS, Sato M, Akutsu H, Okabe M, MekadaE, Sakakibara K, Miyado M, Umezawa A, Miyado K
- Journal Title
  
  Mol Reprod Dev
  
  Volume: 75 Pages: 150-155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] Possible involvement of CD81 in acrosome reaction of sperm in mice.2008
- Author(s)
  Tanigawa,M., Miyamoto,K., Kobayashi,S., Sato,M., Akutsu,H., Okabe,M., Mekada,E., Sakakibara,K., Miyado,M., Umezawa,A., Miyado,K.
- Journal Title
  
  Mol Reprod Dev 75
  
  Pages: 150-155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Heparin-binding epidermal growth factor-likegrowth factor as a new target moleculefor cancer therapy2008
- Author(s)
  Miyamoto S, Yagi H, Yotsumoto F, Kawarabayashi T, Mekada E
- Journal Title
  
  Adv Exp Med Biol
  
  Volume: 622 Pages: 281-295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] Validation of HB-EGF and amphiregulin astargets for human cancer therapy.2008
- Author(s)
  Yotsumoto F, Yagi H, Suzuki SO, Oki E, Tsujioka H, Hachisuga T, Sonoda K, Kawarabayashi T, Mekada E, Miyamoto S.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 365 Pages: 555-561
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] Double deficiency of tetraspanins CD9 and CD81 alters cell motility and protease production of macrophages and causes COPD-like phenotype in mice.2008
- Author(s)
  Takeda,Y., He,P., Tachibana,I., Zhou,B., Miyado,K., Kaneko,H., Suzuki,M., Minami,S., Iwasaki,T., Goya,S., Kijima,T., Kumagai,T., Yoshida,M., Osaki,T., Komori,T., Mekada,E., Kawase,I
- Journal Title
  
  J Biol Chem. 283
  
  Pages: 26089-26097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] HB-EGF decelerates cell proliferation synergistically with TGF-a in perinatal distal lung development.2008
- Author(s)
  Minami, S., Iwamoto, R., Mekada, E.
- Journal Title
  
  Dev. Dyn. 237
  
  Pages: 247-258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] HB-EGF decelerates cell proliferation synergistically with TGF-a in perinatal distal lung development.2008
- Author(s)
  Minami,S., Iwamoto,R., Mekada,E
- Journal Title
  
  Dev. Dyn. 237
  
  Pages: 247-258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] The fusing ability of sperm is bestowed by CD9-containing vesicles released from eggs in mice.2008
- Author(s)
  Miyado K, Yoshida K, Mekada, E, 他15名
- Journal Title
  
  Proc Natl Acad Sci U S A. 105
  
  Pages: 12921-12926
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] Heparin-binding epidermal growth factor-like growth factor as a new target molecule for cancer therapy.2008
- Author(s)
  Miyamoto,S., Yagi,H., Yotsumoto,F., Kawarabayashi,T., Mekada,E.
- Journal Title
  
  Adv Exp Med Biol. 622
  
  Pages: 281-295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] The fusing ability of sperm is bestowed by CD9-containing vesicles released from eggs in mice.2008
- Author(s)
  Miyado K, Yoshida K, Mekada, E, 他15名
- Journal Title
  
  Proc Natl Acad Sci USA. 105
  
  Pages: 12921-12926
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Validation of HB-EGF and amphiregulin as targets for human cancer therapy.2008
- Author(s)
  Yotsumoto,F., Yagi,H., Suzuki,S.O., Oki,E., Tsujioka,H., Hachisuga,T., Sonoda,K., Kawarabayashi,T., Mekada, E., Miyamoto,S.
- Journal Title
  
  Biochem Biophys Res Commun. 365
  
  Pages: 555-561
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] The fusing ability of sperm is bestowed by CD9-containing vesicles released from eggs in mice.2008
- Author(s)
  Miyado,K., Yoshida,K., Yamagata,K., Sakakibara,K., Okabe,M., Wang,X., Miyamoto,K., Akutsu,H., Kondo,T., Takahashi,Y., Ban,T., Ito,C., Toshimori,K., Nakamura,A., Ito,M., Miyado,M., Mekada,E., Umezawa,A
- Journal Title
  
  Proc Natl Acad Sci USA 105
  
  Pages: 12921-12926
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Double deficiency of tetraspanins CD9 and CD81 alters cell motility and protease production of macrophages and causes COPD-like phenotype in mice.2008
- Author(s)
  Takeda Y, He P, Tachibana I, Mekada, E, 他12名
- Journal Title
  
  J Biol Chem. 283
  
  Pages: 26089-26097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] UCSD-Nature Molecule Pages2008
- Author(s)
  Mekada E, Iwamoto R. HB-EGF
- Journal Title
  
  Publishedonline
- DOI
  10.1038/mp.a002932.01
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] Double deficiency oftetraspanins CD9 and CD81 alters cellmotility and protease production of macrophages and causes COPD-likephenotype in mice2008
- Author(s)
  Takeda Y, He P, Tachibana I, Zhou B, Miyado K, Kaneko H, Suzuki M, Minami S, Iwasaki T, Goya S, Kijima T, Kumagai T, Yoshida M, Osaki T, Komori T, Mekada E, Kawase I.
- Journal Title
  
  J Biol Chem
  
  Volume: 283 Pages: 26089-26097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390127
[Journal Article] HB-EGF. UCSD-Nature Molecule Pages.2008
- Author(s)
  Mekada,E., Iwamoto,R.
- Journal Title
  
  Published online 13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Parasporin-1,a novel cytotoxic protein from Bacillus thuringiensis,induces Ca2+ influx and a sustained elevation of the cytoplasmic Ca2+ concentration in toxin-sensitive cells.2007
- Author(s)
  Katayama, H., Kusaka., Yokota, H., Akao, T., Kojima, M., Nakamura, O., Mekada, E., Mizuki,E.
- Journal Title
  
  J.Biol.Chem. (in press)
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Diphtheria toxin mutant CRM197 possesses weak EF2-ADP-ribosyl activity that potentiates its anti-tumorigenic activity2007
- Author(s)
  Kageyama, T., Ohishi, M., Miyamoto, S., Mizushima, H., Iwamoto, R., Mekada, E
- Journal Title
  
  J. Biochem 142
  
  Pages: 95-104
- NAID
  10020098014
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370079
[Journal Article] Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo2007
- Author(s)
  Oki, S., Hashimoto, R., Okui, Y, Shen, M., M., Mekada, E., Otani, H., Saijoh, Y., Hamada, H
- Journal Title
  
  Development 134
  
  Pages: 3893-3904
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370079
[Journal Article] Maternal heparin-binding-EGF deficiency limits pregnancy success in mice.2007
- Author(s)
  Xie,H., Wang,H., Tranguch,S., Iwamoto,R., Mekada,E., DeMayo F.J., Lydon,J.P., Das,S.K., Dey,S.K
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 104
  
  Pages: 18315-18320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Parasporin-1, a novel cytotoxic protein from Bacillus thuringiensis, induces Ca2+ influx and a sustained elevation of the cytoplasmic Ca2+ concentration in toxin-sensitive cells.2007
- Author(s)
  Katayama,H., Kusaka,Y., Yokota,H., Akao,T., Kojima,M., Nakamura,O., Mekada,E. Mizuki,E.
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 7742-7752
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Biologic significance of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) as a pivotal regulator of tumor growth through angiogenesis in human uterine cancer.2007
- Author(s)
  Sonoda,K., Miyamoto,S., Yamazaki,A., Kobayashi,H., Nakashima,M., Mekada, E., Wake,N
- Journal Title
  
  Cancer 110
  
  Pages: 1979-1990
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Parasporin-1,a novel cytotoxic protein from Bacillus thuringiensis,induces Ca2+ influx and a sustained elevation of the cytoplasmic Ca2+ concentration in toxin-sensitive cells.2007
- Author(s)
  Katayama, H., Kusaka., Yokota, H., Akao, T., Kojima, M., Nakamura, O., Mekada, E., Mizuki,E.
- Journal Title
  
  J.Biol.Chem. (In press)
- Data Source
  KAKENHI-PROJECT-18370079
[Journal Article] Parasporin-1, a novel cytotoxic protein from Bacillus thuringiensis, induces Ca2+ influx and a sustained elevation of the cytoplasmic Ca2+ concentration in toxin-sensitive cells2007
- Author(s)
  Katayama, H., Kusaka, Y., Yokota, H., Akao, T., Kojima, M., Nakamura, O., Mekada, E., Mizuki., E
- Journal Title
  
  J. Biol. Chem 282
  
  Pages: 7742-7752
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370079
[Journal Article] Diphtheria toxin mutant CRM197 possesses weak EF2-ADP-ribosyl activity that potentiates its anti-tumorigenic activity.2007
- Author(s)
  Kageyama,T., Ohishi,M., Miyamoto,S., Mizushima,H., Iwamoto,R. Mekada,E
- Journal Title
  
  J.Biochem. 142
  
  Pages: 95-104
- NAID
  10020098014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Cytoplasmic Domain Phosphorylation of Heparin-Binding EGF-like Growth Factor.2006
- Author(s)
  Wang, X., Mizushima, H., Adachi, S., Oishi, M., Iwamoto, R., Mekada, E.
- Journal Title
  
  Cell Struct.Funct. (in press)
- NAID
  130004053854
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] ErbB and HB-EGF signaling in heart development and function.2006
- Author(s)
  Iwamoto, R., Mekada, E.
- Journal Title
  
  Cell Struct. Funct. 31
  
  Pages: 1-14
- NAID
  130004137503
- Data Source
  KAKENHI-PROJECT-18370079
[Journal Article] FRA1 is a determinant for the difference in RAS-induced transformation between human and rat fibroblasts.2006
- Author(s)
  Kakumoto,K., Sasai,K., Sukezane,T., Oneyama,C., Ishimaru,S., Shibutani,K., Mizushima,H., Mekada E., Hanafusa,H. Akagi,T
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 103
  
  Pages: 5490-5495
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] ErbB and HB-EGF signaling in heart development and function.2006
- Author(s)
  Iwamoto,R. Mekada,E
- Journal Title
  
  Cell Struct. Funct. 31
  
  Pages: 1-14
- NAID
  130004137503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Heparin-binding EGF-like growth tactor as a novel targeting molecule for cancer therapy.2006
- Author(s)
  Miyamoto, S., Yagi, H., Yotsumoto, F., Kawarabayashi, T., Mekada,E.
- Journal Title
  
  Cancer Sci. 97
  
  Pages: 341-347
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Cytoplasmic Domain Phosphorylation of Heparin-Binding EGF-like Growth Factor.2006
- Author(s)
  Wang,X., Mizushima,H., Adachi,S., Ohishi,M., Iwamoto,R., Mekada,E.
- Journal Title
  
  Cell Struct. Funct. 31
  
  Pages: 15-27
- NAID
  130004053854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Heparin-binding EGF-like growth factor as a novel targeting molecule for cancer therapy.2006
- Author(s)
  Miyamoto, S., Yagi, H., Yotsumoto, F., Kawarabayashi, T., Mekada,E.
- Journal Title
  
  Cancer Sci. 97
  
  Pages: 341-347
- Data Source
  KAKENHI-PROJECT-18370079
[Journal Article] FRA1 is a determinant for the difference in RAS-induced transformation between human and rat fibroblasts.2006
- Author(s)
  Kakumoto, K., Sasai, K., Sukezane, T., Oneyama, C., Ishimaru, S., Shibutani, K., Mizushima, H., Mekada, E., Hanafusa, H., Akagi, T.
- Journal Title
  
  Proc.Natl.Acad.Sci. USA103
  
  Pages: 5490-5495
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Cytoplasmic Domain Phosphorylation of Heparin-Binding EGF-like Growth Factor.2006
- Author(s)
  Wang, X., Mizushima, H., Adachi, S., Oishi, M., Iwamoto, R., Mekada, E.
- Journal Title
  
  Cell Struct.Funct. (in press.)
- NAID
  130004053854
- Data Source
  KAKENHI-PROJECT-16207014
[Journal Article] ErbB and HB-EGF signaling in heart development and function.2006
- Author(s)
  Iwamoto, R., Mekada, E.
- Journal Title
  
  Cell Struct. Funct. 31
  
  Pages: 1-14
- NAID
  130004137503
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] FRA1 is a determinant for the difference in RAS-induced transformation between human and rat fibroblasts.2006
- Author(s)
  Kakumoto, K., Sasai, K., Sukezane, T., Oneyama, C., Ishimaru, S., Shibutani, K., Mizushima, H., Mekada, E., Hanafusa, H., Akagi,T.
- Journal Title
  
  Proc.Natl.Acad.Sci. USA103
  
  Pages: 5490-5495
- Data Source
  KAKENHI-PROJECT-18370079
[Journal Article] Cytoplasmic Domain Phosphorylation of Heparon-Binding EGF-like Growth Factor.2006
- Author(s)
  Wang, X., Mizushima, H., Adachi, S., Ohishi, M., Iwamoto, R., Mekada,E.
- Journal Title
  
  Cell Struct.Funct. 31
  
  Pages: 15-27
- Data Source
  KAKENHI-PROJECT-18370079
[Journal Article] Heparin -binding EGF-like growth factor as a novel targeting molecule for cancer therapy.2006
- Author(s)
  Miyamoto,s., Yagi,H., Yotsumoto,F., Kawarabayashi,T., Mekada,E.
- Journal Title
  
  Cancer Sci. 97
  
  Pages: 341-347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Cytoplasmic Domain Phosphorylation of Heparon-Binding EGF-like Growth Factor.2006
- Author(s)
  Wang, X., Mizushima, H., Adachi, S., Ohishi, M., Iwamoto, R., Mekada,E.
- Journal Title
  
  Cell Struct.Funct. 31
  
  Pages: 15-27
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Loss of HB-EGF in smooth muscle or endothelial cell lineages causes heart malformation.2006
- Author(s)
  Nanba,D., Kinugasa,Y., Morimoto,C., Koizumi,M., Yamamura,H., Takahashi,K., Takakura,N., Mekada,E., Hashimoto,K., Higashiyama,S.
- Journal Title
  
  Biochem Biophys Res Commun. 350
  
  Pages: 315-321
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] HB-EGF promotes epithelial cell migration in eyelid development.2005
- Author(s)
  Mine, N., Iwamoto, R., Mekada, E.
- Journal Title
  
  Development 132
  
  Pages: 4317-4326
- Data Source
  KAKENHI-PROJECT-16207014
[Journal Article] Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing.2005
- Author(s)
  Shirakata, Y., Kimura, K., Nanba, D., Iwamoto, R., Tokumaru, S., Morimoto, C., Yokota, K., Nakamura, M., Sayama, K., Mekada, E., Higashiyama, S., Hashimoto, K.
- Journal Title
  
  J.Cell Sci. 118
  
  Pages: 2363-2370
- Data Source
  KAKENHI-PROJECT-16207014
[Journal Article] Clinical significance of heparin-binding epidermal growth factor-Like growth factor in peritoneal fluid of ovarian cancer.2005
- Author(s)
  Yagi, H., Miyamoto, S., Tanaka, Y., Sonoda, K., Kobayashi, H., Kishikawa, T., Iwamoto, R., Mekada, E., Nakano, H.
- Journal Title
  
  Brit.J.Cancer 92
  
  Pages: 1737-1745
- Data Source
  KAKENHI-PROJECT-16207014
[Journal Article] HB-EGF promotes epithelial cell migration in eyelid development.2005
- Author(s)
  Mine,N., Iwamoto,R. Mekada,E.
- Journal Title
  
  Development 132
  
  Pages: 4317-4326
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing.2005
- Author(s)
  Shirakata, Y., Kimura, K., Nanba, D., Iwamoto, R., Tokumaru, S., Morimoto, C., Yokota, K., Nakamura, M., Sayama, K., Mekada, E., Higashiyama, S., Hashimoto.K.
- Journal Title
  
  J.Cell Sci. 118
  
  Pages: 2363-2370
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] HB-EGF promotes epithelial cell migration in eyelid development.2005
- Author(s)
  Mine, N., Iwamoto, R., Mekada, E.
- Journal Title
  
  Development 132
  
  Pages: 4317-4326
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Clinical significance of heparin-binding EGF (epidermal growth factor)-like growth factor and ADAM (a disintegrin and metalloprotease) 17 expression in human ovarian cancer.2005
- Author(s)
  Tanaka, T., Miyamoto, S., Suzuki, S.O., Oki, E., Yagi, H., Sonoda, K., Yamazaki, A., Mizushima, H., Maehara, Y., Mekada, E., Nakano, H.
- Journal Title
  
  Clin.Cancer Res. 11
  
  Pages: 4783-4792
- Data Source
  KAKENHI-PROJECT-16207014
[Journal Article] Soluble form of heparin-binding EGF-like growth facto contributes to retinoic acid-induced epidermal hyperplasia.2005
- Author(s)
  Kimura.R., Iwamoto, R., Mekada, E.
- Journal Title
  
  Cell Struct.Funct. 30
  
  Pages: 35-42
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Soluble form of heparin-binding EGF-like growth factor contributes to retinoic acid-induced epidermal hyperplasia.2005
- Author(s)
  Kinmura, R., Iwamoto, R., Mekada, E.
- Journal Title
  
  Cell Struct.Funct. 30
  
  Pages: 35-42
- NAID
  130004137496
- Data Source
  KAKENHI-PROJECT-16207014
[Journal Article] Clinical significance of heparin-binding epidermal growth factor-Like growth factor in peritoneal fluid of ovarian cancer.2005
- Author(s)
  Yagi, H., Miyamoto, S., Tanaka, Y., Sonoda, K., Kobayashi, H., Kishikawa, T., Iwamoto, R., Mekada, E., Nakano, H.
- Journal Title
  
  Brit.J.Cancer 92
  
  Pages: 1737-1745
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Clinical significance of heparin-binding EGF (epidermal growth factor)-like growth factor and ADAM (a disintegrin and metalloprotease) 17 expression in human ovarian cancer.2005
- Author(s)
  Tanaka, T., Miyamoto, S., Suzuki, S.O., Oki, E., Yagi, H., Sonoda, K., Yamazaki, A., Mizushima, H., Maehara, Y., Mekada, E., Nakano, H.
- Journal Title
  
  Clin.Cancer Res. 11
  
  Pages: 4783-4792
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] 卵巣癌の生物学-子宮頸癌・子宮体癌・卵巣癌の診断と治療2004
- Author(s)
  宮本新吾, 目加田英輔
- Journal Title
  
  日本臨床 62・10
  
  Pages: 458-462
- Data Source
  KAKENHI-PROJECT-16591667
[Patent] 制癌剤2008
- Inventor(s)
  目加田英輔、宮本新吾
- Industrial Property Rights Holder
  阪大微生物病研究会
- Acquisition Date
  2008-10-24
- Data Source
  KAKENHI-PROJECT-17014057
[Patent] 抗癌剤の効果増強剤2007
- Inventor(s)
  目加田英輔、宮本新吾
- Industrial Property Rights Holder
  大阪大学、財団法人大阪産業振興機構、福岡大学
- Industrial Property Number
  2007-011939
- Filing Date
  2007-01-22
- Data Source
  KAKENHI-PROJECT-17014057
[Patent] 肺がん治療薬2007
- Inventor(s)
  目加田英輔、宮本新吾
- Industrial Property Rights Holder
  大阪大学、福岡大学
- Industrial Property Number
  2007-167529
- Filing Date
  2007-06-26
- Data Source
  KAKENHI-PROJECT-17014057
[Patent] 連続投与されたCRM197による抗腫瘍効果2007
- Inventor(s)
  目加田英輔、宮本新吾、東雍
- Industrial Property Rights Holder
  国立大学法人大阪大学、学校法人福岡大学、財団法人阪大微生物病研究会
- Industrial Property Number
  2007-180081
- Filing Date
  2007-07-09
- Data Source
  KAKENHI-PROJECT-17014057
[Patent] ヘパリン結合上皮細胞増殖因子様増殖因子に結合するモノクローナル抗体2006
- Inventor(s)
  目加田英輔、岩本亮、宮本新吾、設楽研也、古谷安希子、高橋久美子
- Industrial Property Rights Holder
  大阪大学、福岡大学、協和発酵株式会社
- Industrial Property Number
  2006-157279
- Filing Date
  2006-06-06
- Data Source
  KAKENHI-PROJECT-17014057
[Patent] 分泌型ヘパリン結合上皮細胞増殖因子様増殖因子の測定方法2006
- Inventor(s)
  目加田英輔、岩本亮、宮本新吾、設楽研也、古谷安希子
- Industrial Property Rights Holder
  大阪大学、福岡大学、協和発酵株式会社
- Industrial Property Number
  2006-157278
- Filing Date
  2006-06-06
- Data Source
  KAKENHI-PROJECT-17014057
[Patent] アンフィレギュリン濃度に基づく絨毛膜羊膜炎の診断2006
- Inventor(s)
  吉里俊幸、宮本新吾、瓦林達比古、目加田英輔
- Industrial Property Rights Holder
  福岡大学、大阪大学
- Industrial Property Number
  2006-238576
- Filing Date
  2006-09-04
- Data Source
  KAKENHI-PROJECT-17014057
[Patent] 癌治療薬2006
- Inventor(s)
  目加田英輔、宮本新吾
- Industrial Property Rights Holder
  阪大微生物病研究会
- Acquisition Date
  2006-06-20
- Overseas
- Data Source
  KAKENHI-PROJECT-17014057
[Patent] 癌治療薬2005
- Inventor(s)
  目加田英輔、宮本新吾
- Industrial Property Rights Holder
  大阪大学、関西TLO
- Industrial Property Number
  2005-181314
- Filing Date
  2005-06-21
- Data Source
  KAKENHI-PROJECT-17014057
[Patent] 胃癌、膵癌、グリオブラストーマ等に対する制癌剤2004
- Inventor(s)
  宮本新吾, 目加田英輔
- Industrial Property Rights Holder
  宮本新吾, 目加田英輔
- Filing Date
  2004
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591667
[Patent] ANTICANCER AGENT(乳癌、卵巣癌等に対する制癌剤)2004
- Inventor(s)
  宮本新吾, 目加田英輔
- Industrial Property Rights Holder
  宮本新吾, 目加田英輔
- Filing Date
  2004
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591667
[Patent] 制癌剤 : CRM197と他剤との併用療法(CRM197とタキソールの併用)2004
- Inventor(s)
  宮本新吾, 目加田英輔
- Industrial Property Rights Holder
  宮本新吾, 目加田英輔
- Filing Date
  2004
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591667
[Patent] CD9/CD81二重欠損非ヒト動物
- Inventor(s)
  目加田英輔, 他3名
- Industrial Property Number
  2003-162916
- Overseas
- Data Source
  KAKENHI-PROJECT-17014057
[Presentation] ジフテリア毒素リセプターの同定から始まった細胞増殖因子研究2015
- Author(s)
  目加田英輔
- Organizer
  酵素学ウインタースクール酵素学講演会
- Place of Presentation
  徳島
- Year and Date
  2015-01-19
- Invited
- Data Source
  KAKENHI-PROJECT-26250033
[Presentation] 線虫におけるDual Oxidase/BLI-3の役割2015
- Author(s)
  森部弘樹、小央良二、目加田英輔
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26440107
[Presentation] FAKリン酸化によるHB-EGF依存的細胞増殖制御2014
- Author(s)
  水島寛人、船越敍希、目加田英輔
- Organizer
  第66回日本細胞生物学会大会
- Place of Presentation
  奈良
- Year and Date
  2014-06-11
- Data Source
  KAKENHI-PROJECT-26250033
[Presentation] 破骨細胞分化過程におけるHB-EGF細胞質内領域の機能2014
- Author(s)
  中村尚志、岩本亮、目加田英輔
- Organizer
  第66回日本細胞生物学会大会
- Place of Presentation
  奈良
- Year and Date
  2014-06-11
- Data Source
  KAKENHI-PROJECT-26250033
[Presentation] HB-EGFを標的とする抗癌剤の開発2014
- Author(s)
  目加田英輔
- Organizer
  第25回日本消化器癌発生学会総会ランチョンセミナー
- Place of Presentation
  福岡
- Year and Date
  2014-11-14
- Invited
- Data Source
  KAKENHI-PROJECT-26250033
[Presentation] 心臓弁形成におけるHB-EGF-EｒｂBシグナルによる細胞増殖制御2014
- Author(s)
  岩本亮、目加田英輔
- Organizer
  第66回日本細胞生物学会大会
- Place of Presentation
  奈良
- Year and Date
  2014-06-11
- Data Source
  KAKENHI-PROJECT-26250033
[Presentation] Sequestration of FAK on microtubule negatively regulates HB-EGF-dependent cell growth2013
- Author(s)
  Hiroto Mizushima, Mitsuki Funakoshi, Eisuke Mekada
- Organizer
  第65回日本細胞生物学会大会
- Place of Presentation
  ウインクあいち（愛知県産業労働センター）
- Data Source
  KAKENHI-PROJECT-23570227
[Presentation] HB-EGF and PDGF Mediate Reciprocal Interactions of Carcinoma Cells with Cancer-Associated Fibroblasts to Support Progression of Uterine Cervical Cancers2012
- Author(s)
  Hiroto Mizushima, Takuya Murata, Ichino Chinen, Hiroki Moribe, Shigeo Yagi, Robert M Hoffman, Tadashi Kimura, Kiyoshi Yoshino, Yutaka Ueda, Takayuki Enomoto, Eisuke Mekada
- Organizer
  第４５回日本発生学会、第６４回日本細胞生物学会合同大会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-23570227
[Presentation] The role of tetraspanins in the dual oxidase system of C.elegans and humans2011
- Author(s)
  Mekada E
- Organizer
  FASEB Summer Research Conferences Membrane Organization by Molecular Scaffolds
- Place of Presentation
  Vermont Academy (U.S.A)(招待講演)
- Data Source
  KAKENHI-PROJECT-20390127
[Presentation] The role of tetraspanins in the dual oxidase system of C.elegans and humans.2011
- Author(s)
  Eisuke Mekada
- Organizer
  FASEB Summer Research Conferences Membrane Organization by Molecular Scaffolds.
- Place of Presentation
  Saxtons River, Vermont (U.S.A.)
- Invited
- Data Source
  KAKENHI-PROJECT-23240126
[Presentation] HB-EGF細胞質内フラグメントは破骨細胞の分化を負に制御する2011
- Author(s)
  中村尚志、伊藤ちひろ、北川教弘、岩本亮、竹家達夫、目加田英輔
- Organizer
  第63回日本細胞生物学会大会
- Place of Presentation
  北海道大学
- Data Source
  KAKENHI-PROJECT-20390127
[Presentation] テトラスパニンによる活性酸素産生の制御2011
- Author(s)
  森部弘樹、小央良二、中村邦明、目加田英輔
- Organizer
  第63回日本細胞生物学会大会
- Place of Presentation
  北海道大学
- Data Source
  KAKENHI-PROJECT-20390127
[Presentation] FAKのFERMドメインのリン酸化によるHB-EGF依存的細胞増殖制御2011
- Author(s)
  水島寛人、船越敍希、目加田英輔
- Organizer
  第63回日本細胞生物学会大会
- Place of Presentation
  北海道大学
- Data Source
  KAKENHI-PROJECT-20390127
[Presentation] 子宮頚癌ではHB-EGFとPDGFを介して癌細胞と癌関連線維芽細胞が相互作用し、癌細胞の増殖を促進する2011
- Author(s)
  村田卓也、水島寛人、吉野潔、上田豊、榎本隆之、木村正、目加田英輔
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-20390127
[Presentation] テトラスパニンによる活性酸素産生の制御2011
- Author(s)
  森部弘樹、小央良二、中村邦明、目加田英輔
- Organizer
  第63回日本細胞生物学会大会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20390127
[Presentation] Clinical development of the diphtheria toxin mutant CRM197 for cancer therapy2011
- Author(s)
  Mekada E
- Organizer
  ETOX15 European Workshop on Bacterial Protein Toxins
- Place of Presentation
  Soria Moria Hotel and Conference Centre, Oslo (Norway)
- Data Source
  KAKENHI-PROJECT-20390127
[Presentation] Clinical development of the diphtheria toxin mutant CRM197 for cancer therapy.2011
- Author(s)
  Eisuke Mekada
- Organizer
  ETOX15 European Workshop on Bacterial Protein Toxins.
- Place of Presentation
  Oslo (Norway)
- Invited
- Data Source
  KAKENHI-PROJECT-23240126
[Presentation] HB-EGF細胞質内フラグメントは破骨細胞の分化を負に制御する2011
- Author(s)
  中村尚志、伊藤ちひろ、北川教弘、岩本亮、竹家達夫、目加田英輔
- Organizer
  第63回日本細胞生物学会大会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20390127
[Presentation] Clinical development of the diphtheria toxin mutant CRM197 forcancer therapy2011
- Author(s)
  Mekada E
- Organizer
  ETOX15 European Workshop on Bacterial Protein Toxins
- Place of Presentation
  Oslo, Norway
- Data Source
  KAKENHI-PROJECT-20390127
[Presentation] The role of tetraspanins in the dual oxidase system of C. elegansand humans2011
- Author(s)
  Mekada E
- Organizer
  Membrane Organization by Molecular Scaffolds
- Place of Presentation
  Saxtons River, Vermont
- Data Source
  KAKENHI-PROJECT-20390127
[Presentation] FAKのFERMドメインのリン酸化によるHB-EGF依存的細胞増殖制御2011
- Author(s)
  水島寛人、船越敍希、目加田英輔
- Organizer
  第63回日本細胞生物学会大会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20390127
[Presentation] 癌随伴線維芽細胞はHB-EGFおよびPDGFを介して子宮頚癌細胞の増殖を促進する2010
- Author(s)
  村田卓也、水島寛人、榎本隆之、木村正目加田英輔
- Organizer
  第62回日本細胞生物学会大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20390127
[Presentation] HB-EGF is a novel therapeutic target for ovarian cancer2010
- Author(s)
  Mekada, E
- Organizer
  8th Joint Conference of the American Association For Cancer Research and the Japanese Cancer Association
- Place of Presentation
  Hawaii, USA(招待講演)
- Year and Date
  2010-02-09
- Data Source
  KAKENHI-PROJECT-17014057
[Presentation] FAKはHB-EGF依存的な細胞増殖に必要である2010
- Author(s)
  船越敍希、水島寛人、目加田英輔
- Organizer
  第62回日本細胞生物学会大会
- Place of Presentation
  大阪国際会議場
- Data Source
  KAKENHI-PROJECT-20390127
[Presentation] 線虫外骨格形成においてテトラスパニンにより制御される分子経路の同定2010
- Author(s)
  森部弘樹、小央良二、中村邦明、目加田英輔
- Organizer
  第62回日本細胞生物学会大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20390127
[Presentation] FAKはHB-EGF依存的な細胞増殖に必要である2010
- Author(s)
  船越敍希、水島寛人、目加田英輔
- Organizer
  第62回日本細胞生物学会大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20390127
[Presentation] HB-EGF is a novel therapeutic target for ovarian cancer : Development of an HB-EGF inhibitor as an anticancer drug.2010
- Author(s)
  Eisuke Mekada
- Organizer
  at 8^th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association
- Place of Presentation
  Hawaii, USA.
- Data Source
  KAKENHI-PROJECT-17014057
[Presentation] HB-EGFの作用機構と癌分子標的としての解析2010
- Author(s)
  目加田英輔
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-20390127
[Presentation] HB-EGF-EGFRシグナルは多重の経路を介して骨芽細胞の分化を制御する2010
- Author(s)
  中村尚志、北川教弘、岩本亮、竹家達夫目加田英輔
- Organizer
  第62回日本細胞生物学会大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20390127
[Presentation] HB-EGF is a novel therapeutic target for ovarian cancer : Development of an HB-EGF inhibitor as an anticancer drug2010
- Author(s)
  Eisuke Mekada
- Organizer
  at 8th Joint Conference of the American Associationfor Cancer Research and the Japanese Cancer Association
- Place of Presentation
  Hawaii, USA
- Data Source
  KAKENHI-PROJECT-20390127
[Presentation] 線虫外骨格形成においてテトラスパニンにより制御される分子経路の同定2010
- Author(s)
  森部弘樹、小央良二、中村邦明、目加田英輔
- Organizer
  第62回日本細胞生物学会大会
- Place of Presentation
  大阪国際会議場
- Data Source
  KAKENHI-PROJECT-20390127
[Presentation] HB-EGFの作用機構と癌分子標的としての解析2010
- Author(s)
  目加田英輔
- Organizer
  日本癌学会
- Place of Presentation
  大阪
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-17014057
[Presentation] HB-EGF-EGFRシグナルは多重の経路を介して骨芽細胞の分化を制御する2010
- Author(s)
  中村尚志、北川教弘、岩本亮、竹家達夫、目加田英輔
- Organizer
  第62回日本細胞生物学会大会
- Place of Presentation
  大阪国際会議場
- Data Source
  KAKENHI-PROJECT-20390127
[Presentation] HB-EGFの作用機構と癌分子標的としての解析2010
- Author(s)
  目加田英輔
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  リーガロイヤルホテル大阪
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-20390127
[Presentation] 癌随伴線維芽細胞はHB-EGFおよびPDGFを介して子宮頚癌細胞の増殖を促進する2010
- Author(s)
  村田卓也、水島寛人、榎本隆之、木村正、目加田英輔
- Organizer
  第62回日本細胞生物学会大会
- Place of Presentation
  大阪国際会議場
- Data Source
  KAKENHI-PROJECT-20390127
[Presentation] インテグリンシグナルはEGFファミリー増殖因子の増殖因子活性を単層培養において不顕在化する2009
- Author(s)
  水島寛人、宮本新吾、目加田英輔
- Organizer
  第61回日本細胞生物学会大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-17014057
[Presentation] インテグリンシグナルはEGFファミリー増殖因子の増殖因子活性を単層培養において不顕在化する2009
- Author(s)
  水島寛人、宮本新吾、目加田英輔
- Organizer
  第61回日本細胞生物学会大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20390127
[Presentation] The analysis of cell-polarizing mechanism in early C.elegans embryo2009
- Author(s)
  Mekada,E, Nakamura,K
- Organizer
  第61回日本細胞生物学会大会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2009-06-02
- Data Source
  KAKENHI-PROJECT-17014057
[Presentation] Host-derived HB-EGF contributes to xenografted tumor growth. ; Study of humanized HB-EGF knock-in mice2009
- Author(s)
  Mekada, E, Ichise, T, Ikawa, M, Okabe, M
- Organizer
  第61回日本細胞生物学会大会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2009-06-02
- Data Source
  KAKENHI-PROJECT-17014057
[Presentation] Genetic investigation of regulatory pathway of tetraspanin and its associated molecules in C.elegans2009
- Author(s)
  Mekada, E, Moribe, H, Konakawa, R
- Organizer
  第61回日本細胞生物学会大会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2009-06-02
- Data Source
  KAKENHI-PROJECT-17014057
[Presentation] HB-EGFの生理機能発揮におけるエクトドメイン・シェディングの役割2008
- Author(s)
  岩本亮、目加田英輔
- Organizer
  第60回日本細胞生物学会大会
- Place of Presentation
  横浜
- Year and Date
  2008-06-29
- Data Source
  KAKENHI-PROJECT-17014057
[Presentation] HB-EGFの生理機能発揮におけるエクトドメイン・シェディングの役割2008
- Author(s)
  岩本亮、目加田英輔
- Organizer
  第60回日本細胞生物学会大会
- Place of Presentation
  横浜
- Year and Date
  2008-06-29
- Data Source
  KAKENHI-PROJECT-20390127
[Presentation] HB-EGF as a new target molecule for cancer therapy2007
- Author(s)
  Eisuke, Mekada
- Organizer
  66th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Yokohama
- Year and Date
  2007-10-04
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370079
[Presentation] HB-EGF:新しいがんの分子標的2007
- Author(s)
  目加田英輔
- Organizer
  日本癌学会
- Place of Presentation
  横浜
- Year and Date
  2007-10-04
- Data Source
  KAKENHI-PROJECT-17014057
[Presentation] Regulation of HB-EGFfunction by HSPGs2007
- Author(s)
  岩本亮、目加田英輔
- Organizer
  第40回日本発生生物学会・第59回日本細胞生物学会合同大会
- Place of Presentation
  福岡
- Year and Date
  2007-05-29
- Data Source
  KAKENHI-PROJECT-17014057
[Presentation] HB-EGF:新しいがんの分子標的2007
- Author(s)
  目加田英輔
- Organizer
  日本癌学会
- Place of Presentation
  横浜
- Year and Date
  2007-10-04
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370079
[Presentation] 骨のリモデリング制御因子としてのHB-EGFの役割2007
- Author(s)
  中村尚志、吉本晃正、戸井田英俊、小川拓哉、北川(石田)教弘、岩本亮、目加田英輔、竹家達夫
- Organizer
  第30回日本分子生物学会・第80回日本生化学会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17014057
[Presentation] ErbB signaling in cartilage and bone development.2006
- Author(s)
  Dealy,C.N., Fisher,M., Omi,M., Seghatoleslami,M.R., Clinton,G.M., Maihle,N.J., Iwamoto,R., Mekada,E., Mine,N.
- Organizer
  9^<th> International Conference on Limb Development and Regeneration, Awaji
- Year and Date
  2006-07-26
- Data Source
  KAKENHI-PROJECT-17014057
[Presentation] ヘパラン硫酸プロテオグリカンによる増殖因子HB-EGFの生理機能制御2006
- Author(s)
  岩本亮、目加田英輔
- Organizer
  日本分子生物学会2006フォーラム
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-17014057
[Presentation] HB-EGF promotes epithelial cell migration in eyelid development.2005
- Author(s)
  Mine,N., Iwamoto,R., Mekada,E.
- Organizer
  The 45^th Annual Meeting of The American Society for Cell Biology, San Francisco
- Year and Date
  2005-12-13
- Data Source
  KAKENHI-PROJECT-17014057
[Presentation] FAKリン酸化によるHB-EGF依存的細胞増殖制御
- Author(s)
  水島寛人、船越敍希、目加田英輔
- Organizer
  第６６回日本細胞生物学会大会
- Place of Presentation
  奈良県新公会堂
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-23570227
[Presentation] Regulation of HB-EGF-dependent cell growth by phosphorylation of FERM domain of FAK
- Author(s)
  Hiroto Mizushima, Mitsuki Funakoshi, Eisuke Mekada
- Organizer
  第６３回日本細胞生物学会大会
- Place of Presentation
  北海道大学クラーク会館、学術交流会館（北海道）
- Data Source
  KAKENHI-PROJECT-23570227

1. IWAMOTO Ryo (10213323)

# of Collaborated Projects: 32 results

# of Collaborated Products: 37 results
2. TSUNEOKA Makoto (50197745)

# of Collaborated Projects: 22 results

# of Collaborated Products: 0 results
3. UMATA Toshiyuki (30213482)

# of Collaborated Projects: 18 results

# of Collaborated Products: 0 results
4. MITAMURA Toshihide (80268846)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
5. SEKIGUCHI Kiyotoshi (50187845)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
6. MIZUSHIMA Hiroto (30379094)

# of Collaborated Projects: 6 results

# of Collaborated Products: 26 results
7. MIYAZAKI Kaoru (70112068)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
8. NAKAMURA Kuniaki (70311305)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
9. MIYADO Kenji (60324844)

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# of Collaborated Products: 0 results
10. SOBUE Kenji (20112047)

# of Collaborated Projects: 3 results

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11. KOSAI Ken-ichiro (90258418)

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12. YONEDA Yoshihiro (80191667)

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13. HIGASHIYAMA Shigeki (60202272)

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14. ASANO Shiro (00397613)

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15. YAMAIZUMI Masaru (70107093)

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16. MORI Osamu (20129597)

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17. UCHIDA Tsuyoshi (40029781)

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18. KANEDA Yasufumi (10177537)

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19. 松浦成昭 (70190402)

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20. 済木育夫 (80133776)

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21. 山田源 (80174712)

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22. MURPHY Johon

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23. KLAGSBRUN Michael

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24. SABE Hisataka (40187282)

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25. OZAWA Masayuki (90136854)

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26. NARUMIYA Shuh (70144350)

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27. TUJI Tsutomu (00143503)

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28. GU Jianguo (30314420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. NAKAMA Takekuni (50221453)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. KUSUHARA Masahiro (40195441)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. MORI Osamu (10175630)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. ITO Kyogo (50125499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. MIYAMOTO Shingo (40209945)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
34. SONODA Kenzo (30294929)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. ISHIURA Masahiro (20132730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. NAKAMURA Takashi (00570673)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
37. MORIBE Hiroki (90423102)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
38. 永渕昭良 (80218023)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 眞鍋理一郎 (30280837)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 河野憲二 (50142005)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. YONEDA Tomoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. JOHON R.Murp

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. MICHAEL Klag

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. CARTER Willi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. 浅井知浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
46. 岡田雅人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MEKADA Eisuke 目加田 英輔

目加田 英輔 メカダ エイスケ

Research Projects

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Development of a novel anti-cancer therapeutics targeting HB-EGFPrincipal Investigator

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The role of HB-EGF in cancer cell proliferation and malignancyPrincipal Investigator

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Identification of host cell factors involved in diphtheria toxin sensitivity by using shRNA library.Principal Investigator

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Identification of genes involved in the ectodomain sheddingof HB-EGFPrincipal Investigator

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Cell function regulation by membrane-anchored growth factorsPrincipal Investigator

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Analysis of the ectodomain shedding mechanism of HB-EGFPrincipal Investigator

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Growth regulation mediated by EGF family of growth factorsPrincipal Investigator

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膜結合型増殖因子と細胞間接着因子による細胞増殖および浸潤制御Principal Investigator

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Analysis of the function of CD9 and tetraspaninsPrincipal Investigator

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MEKADA Eisuke 目加田英輔

目加田英輔メカダエイスケ