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YOSHIDA Takemi  吉田 武美

ORCIDConnect your ORCID iD *help
Researcher Number 20138415
Affiliation (based on the past Project Information) *help 2007 – 2008: Showa University, 薬学部, 教授
1992 – 2004: Sch.Pharm.Sci., Professor Showa University, 薬学部, 教授
1991: 昭和大学, 薬学部, 助教授
1986: Associate-Professor, School of Pharmaceutical Sciences, 薬学部毒物学, 助教授
Review Section/Research Field
Principal Investigator
Biological pharmacy / Environmental pharmacy / Environmental pharmacy / Biological Sciences
Except Principal Investigator
Biological pharmacy / Conservative dentistry / Conservative dentistry
Keywords
Principal Investigator
分化誘導 / シトクロムP450 / Na^+,K^+-ATPase / ブファリン / 酸化的ストレス / アポトーシス / CYP2B / STAT / LPS / BCG … More / MAPK / サイトカイン / ヘムオキシゲナーゼ-1 / Cytochrome P450 / oxidative stress / Metallothionein / グルタチオン枯渇 / チトクロム P-450 / スチルベンオキシド / メタロチオネイン / ヘムオキシゲナーゼ / CAR / U937細胞 / 白血病細胞 / Constitutive androstane receptor / Cocaine / Heine oxygenase-1 / HTLV-I Tg mouse / Lipopolysaccharide / Cytokine / オーラノフィン / 炎症性サイトカイン / 関節リウマチ / 肝障害 / 酸化ストレス / ヘムオシゲナーゼ-1 / コカイン / HTLV-I Tgマウス / リポポリサッカライド / cytokine / heme oxygenese-1 / cytochromeP450 / IL-6 / TNFα / Dipyridyls / Phorone / HepG2 cell / Heme oxygenase / Glutathione depletion / 熱ショックタンパク質 / ストレス応答 / シトクロム P450 / ジピリジル系化合物 / フォロン / HepG2細胞 / Liver / Stilbene Oxide / Enzyme Induction / Cytochrome P-450 / Heme Oxygenase / Oxidative Stress / Glutathione / チトクロムPー450 / ヘムオキシゲナ-ゼ / 肝臓 / 酵素誘導 / チトクロムP-450 / グルタチオン / Cyp2b10 / マウス / NADPH:quinone oxidoreductase-1 / heme oxygenase-1 / 誘導型-酸化窒素合成酵素 / カドミウム / 5-フルオロウラシル / トキシコゲノミクス / ヘムオキシゲナーゼー1 / Nrf2 / シグナル伝達 / 遺伝子発現 / カルシウムイオン / PKC / P38 / ERK / トポイソメラーゼII / カゼインキナーゼ2 / 血管新生 / ウワバイン / THP-1細胞 / MAPキナーゼ / 抗腫瘍作用 / 癌遺伝子 / ブファジエノリド … More
Except Principal Investigator
GM / 2-HEMA / CYP / BCG / MAPK / LPS / TNFα / Maximization Test / dentin primer / HEMA / contact dermatitis / cytochrome P-450 / phenobarbirtal / biomembrane / ESR / spin-label / rat liver microsomes / 生体膜 / フェノバルビタール / 電子スピン共鳴 / 膜流動性 / チトクロームP-450 / 酵素誘導 / スピンラベル / 肝小胞体 / Dentin / Discoloration / 原子吸光度 / 象牙質 / 変色 / delayed / allergy / 特異染色 / 2-HEMA抗体 / 遅延型 / ガスクロマトグラフィー / metallothionein / heme oxygenase / cytokine / ノックアウトマウス / 酸化ストレス / メタロチオネイン / ヘムオキシゲナーゼ / サイトカイン / delayd Allergy / GPMT / アレルギー反応 / デイティンプライマー / Maximization test / delayed Allergy / Standerdization / Terms in pharmaceutical sciences / Scientific terms / 標準化 / 薬学用語 / 学術用語 Less
  • Research Projects

    (16 results)
  • Research Products

    (8 results)
  • Co-Researchers

    (37 People)
  •  トキシコゲノミクスを基盤とした新規生体防御因子の探索Principal Investigator

    • Principal Investigator
      吉田 武美
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Environmental pharmacy
    • Research Institution
      Showa University
  •  Elucidation of defensive mechanism against xenobiotics in cytokine knock out and pathologic model micePrincipal Investigator

    • Principal Investigator
      YOSHIDA Takemi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Environmental pharmacy
    • Research Institution
      Showa University
  •  Development of the protein caused by discoloration teeth resolution enzyme.

    • Principal Investigator
      MANABE Atsufumi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Conservative dentistry
    • Research Institution
      Showa University
  •  Na^+,K^+-ATPase阻害剤による抗癌作用機構解明とその臨床応用Principal Investigator

    • Principal Investigator
      吉田 武美
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Showa University
  •  The influence of the dental monomer to the dentin and a oral mucose

    • Principal Investigator
      MANABE Atsufumi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Conservative dentistry
    • Research Institution
      Showa University
  •  Changes in cytochrome P450 and stress responsive proteins under oxidative stressPrincipal Investigator

    • Principal Investigator
      YOSHIDA Takemi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Environmental pharmacy
    • Research Institution
      Showa university
  •  Study on possible role of cytokines in response to oxidative stress by using cytokine knock out mice

    • Principal Investigator
      OGURO Takiko
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Showa university
  •  Na,K-ATPase阻害と癌細胞分化やアポトーシス誘導への情報伝達機構解明Principal Investigator

    • Principal Investigator
      吉田 武美
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Showa University
  •  ブファリンの標的Na,K-ATPase阻害と分化や細胞死の誘導機構解明と抗癌剤開発Principal Investigator

    • Principal Investigator
      吉田 武美
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Showa University
  •  Na^+,K^+-ATPaseを標的とするブファリンの分化誘導機構解明と抗癌剤としての開発Principal Investigator

    • Principal Investigator
      吉田 武美
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Showa University
  •  The investigation of side dffects to the fingertips caused by dental adhesive monomers.

    • Principal Investigator
      MANABE Atsufumi
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Conservative dentistry
    • Research Institution
      Showa University
  •  生薬センソ成分ブファリンの癌細胞分化誘導機構解明と新たな制癌剤としての開発研究Principal Investigator

    • Principal Investigator
      吉田 武美
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Showa University
  •  Multiple Oxidative Stress Responses for Hepatic Glutathione Depletion Evoked by Drugs and chemicalsPrincipal Investigator

    • Principal Investigator
      YOSHIDA Takemi
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Showa University
  •  Investigation for the Standardization of Terms on Pharmaceutical Sciences

    • Principal Investigator
      SUGA Tetsuya
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Institution
      Tokyo College of Pharmacy
  •  Specific Induction of Enzymes in the Liver Accompanying by Oxidative Stress after Glutathione depletion and Its Significance.Principal Investigator

    • Principal Investigator
      YOSHIDA Takemi
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      SHOWA UNIVERSITY
  •  Studies on the relation between the biological function and the dynamic properties of rat liver plasma and microsomal membranes

    • Principal Investigator
      UTSUMI Hideo
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Showa University

All 2008 2007 2005 2004 Other

All Journal Article Presentation

  • [Journal Article] Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages2008

    • Author(s)
      T. Ashino, R. Yamanaka, M. Yamamoto, H. Shimokawa, K. Sekikawa, Y. Iwakura, S. Shioda, S. Numazawa, T. Yoshida
    • Journal Title

      Molecular Immunology 45

      Pages: 2106-2115

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659030
  • [Journal Article] Redox reguration of a transcriptional repressor Bach12005

    • Author(s)
      Ishikawa M, Numazawa S, Yoshida T.
    • Journal Title

      Free Radical Biology and Medicine (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390041
  • [Journal Article] Involvement of interleukin-G and tumor necrosis factor a in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver2004

    • Author(s)
      Ashino T, Oguro T, Shioda S, Horai R, Asano M, Sekikawa K, Iwakura Y, Numazawa S, Yoshida T
    • Journal Title

      Drug Metabolism and Disposition 32(7)

      Pages: 707-714

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390041
  • [Journal Article] Involvement of interleukin-6 and tumor necrosis factor α in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver2004

    • Author(s)
      Ashino T, Oguro T, Shioda S, Horai R, Asano M, Sekikawa K, Iwakura Y, Numazawa S, Yoshida T.
    • Journal Title

      Drug Metabolism and Disposition Vol.32,No.7

      Pages: 707-714

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390041
  • [Journal Article] Nrf2-dependent gene expressions: A molecular toxicological aspect2004

    • Author(s)
      T Yoshida, S Numazawa
    • Journal Title

      The journal of toxicological sciences 29

    • NAID

      110001812860

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15592030
  • [Journal Article] Involvement of interleukin-6 and tumor necrosis factor α in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver2004

    • Author(s)
      Ashino T, Oguro T, Shioda S, Horai R, Asano M, Sekikawa K, Iwakura Y, Numazawa S, Yoshida T.
    • Journal Title

      Drug Metabolism and Disposition Vol.32, No.7

      Pages: 707-714

    • Data Source
      KAKENHI-PROJECT-15390041
  • [Journal Article] Redox reguratiorn of a transcriptional repressor Bach1

    • Author(s)
      Ishikawa M, Numazawa S, Yoshida T
    • Journal Title

      Free Radical Biology and Medicine (In press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390041
  • [Presentation] Induction of CYP2B10 and CYP2A gene expressions by Nrf2 activators2007

    • Author(s)
      H. Ohkubo, T. Ashino, M. Yamamoto, S. Numazawa, T. Yoshida
    • Organizer
      8th International ISSX Meeting
    • Place of Presentation
      仙台
    • Year and Date
      2007-10-11
    • Data Source
      KAKENHI-PROJECT-19659030
  • 1.  NUMAZAWA Satoshi (80180686)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 5 results
  • 2.  ASHINO Takashi (00338534)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 5 results
  • 3.  OGURO Takiko (10185572)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  MANABE Atsufumi (40199906)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  TANAKA Sachiko (00197419)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  NAKAYAMA Sadao (00054007)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  ITOH Kazuo (30129811)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  SUGA Tetsuya (20057318)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  RIKIHISA Tadaaki (70012622)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  YAMANOUCHI Sakae (20059249)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  MISAWA Miwa (20061294)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  NAGAI Tuneji (40061270)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  TOMIOKA Kiyoshi (50114575)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  SAMEJIMA Keijiro (00072413)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  IIJIMA Masafumi (20010449)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  SASA Ryuzi (20014201)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  MAEDA Masako (00053869)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  OGUCHI Katsuzi (50129821)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  UTSUMI Hideo (20101694)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  山元 俊憲 (30112741)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  中谷 一泰 (40053855)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  黒岩 幸雄 (20053796)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  黒沢 雅広 (10297020)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  渡部 正彦 (90301788)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  貝崎 明日香 (70407443)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  佐用 博照 (70068302)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  三川 潮 (60012613)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  首藤 紘一 (50012612)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  北澤 式文 (50026887)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  辻 章夫 (80053784)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  寺尾 允男 (60012605)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  粟津 荘司 (60012621)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  野村 靖幸 (00034041)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  狐塚 寛 (60092748)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  濱田 昭 (50053781)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  安富祖 文香 (30349039)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  三輪 亮寿
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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