HIRUMA Toru 比留間徹

Researcher Number	20254188
Affiliation (based on the past Project Information) *help	2017 – 2023: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, 部長 2016: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 骨軟部腫瘍外科, 部長
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related Except Principal Investigator Basic Section 56020:Orthopedics-related / Orthopaedic surgery
Keywords	Principal Investigator CDK4/6阻害剤 / PDX / 脱分化型脂肪肉腫 / 患者由来ゼノグラフト Except Principal Investigator アディポカイン / 脂肪細胞 / 骨転移 / がん微小環境 / 腫瘍関連脂肪細胞 / adipo-oncology … More / エピジェネティクス / アディポネクチン / adipocytes / がん / ホルモン / マウス転移モデル / エクソソーム / がん-間質相互作用 / 癌微小環境 / 分化誘導 / 動物モデル / 骨髄脂肪細胞 / AI解析 / 腫瘍免疫 / 治療抵抗性 / 骨軟部肉腫 / 整形外科 / ゲノム / 癌 / 融合遺伝子 / 骨軟部腫瘍 / がんゲノム / ゲノム解析 / 肉腫 Less

Investigation of the suppression mechanism of bone marrow adipocyte-derived adiponectin on bone metastatic cancer
- Principal Investigator
  
  佐藤慎哉
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kanagawa Cancer Center Research Institute
The role of adipocyte-derived hormones/extracellular vesicles on bone-metastasized cancer
- Principal Investigator
  
  Sato Shinya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kanagawa Cancer Center Research Institute
Development of therapeutic strategies for DDLS with CDK4 inhibitor in PDXPrincipal Investigator
- Principal Investigator
  
  HIRUMA Toru
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kanagawa Cancer Center Research Institute
Identification of diagnostic biomarker and novel fusion genes of bone and soft tissue sarcoma
- Principal Investigator
  
  Matsuda Koichi
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo

All 2023 2022 2020 2017 2016 Other

All Journal Article Presentation Other

[Journal Article] Bone marrow adipocytes induce cancer‐associated fibroblasts and immune evasion, enhancing invasion and drug resistance2023
- Author(s)
  Sato Shinya、Hiruma Toru、Koizumi Mitsuyuki、Yoshihara Mitsuyo、Nakamura Yoshiyasu、Tadokoro Hiroko、Motomatsu Sadako、Yamanaka Takashi、Washimi Kota、Okubo Yoichiro、Yoshioka Emi、Kasajima Rika、Yamashita Toshinari、Kishida Takeshi、Yokose Tomoyuki、Miyagi Yohei
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 6 Pages: 2674-2688
- DOI
  10.1111/cas.15786
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09422, KAKENHI-PROJECT-23K08708
[Journal Article] Histological markers, sickle-shaped blood vessels, myxoid area, and infiltrating growth pattern help stratify the prognosis of patients with myxofibrosarcoma/undifferentiated sarcoma2023
- Author(s)
  Washimi Kota、Kasajima Rika、Shimizu Eigo、Sato Shinya、Okubo Yoichiro、Yoshioka Emi、Narimatsu Hiroto、Hiruma Toru、Katayama Kotoe、Yamaguchi Rui、Yamaguchi Kiyoshi、Furukawa Yoichi、Miyano Satoru、Imoto Seiya、Yokose Tomoyuki、Miyagi Yohei
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1
- DOI
  10.1038/s41598-023-34026-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09422, KAKENHI-PROJECT-20K16210, KAKENHI-PROJECT-23K11300
[Journal Article] Differential diagnosis of lipoma and atypical lipomatous tumor/well‐differentiated liposarcoma by cytological analysis2022
- Author(s)
  Sugiyama Kana、Washimi Kota、Sato Shinya、Hiruma Toru、Sakai Mai、Okubo Yoichiro、Miyagi Yohei、Yokose Tomoyuki
- Journal Title
  
  Diagnostic Cytopathology
  
  Volume: 50 Issue: 3 Pages: 112-122
- DOI
  10.1002/dc.24928
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09422, KAKENHI-PROJECT-20K16210
[Journal Article] Efficacy of Trabectedin in Patients with Advanced Translocation‐Related Sarcomas: Pooled Analysis of Two Phase II Studies2017
- Author(s)
  Takahashi Mitsuru、Takahashi Shunji、Araki Nobuhito、Sugiura Hideshi、Ueda Takafumi、Yonemoto Tsukasa、Morioka Hideo、Hiraga Hiroaki、Hiruma Toru、Kunisada Toshiyuki、Matsumine Akihiko、Shimura Masashi、Kawai Akira
- Journal Title
  
  The Oncologist
  
  Volume: 22 Issue: 8 Pages: 979-988
- DOI
  10.1634/theoncologist.2016-0064
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10862, KAKENHI-PROJECT-16K10874, KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-15K10440
[Journal Article] Results of sub-analysis of a phase 2 study on trabectedin treatment for extraskeletal myxoid chondrosarcoma and mesenchymal chondrosarcoma.2016
- Author(s)
  Morioka H, Takahashi S, Araki N, Sugiura H, Ueda T, Takahashi M, Yonemoto T, Hiraga H, Hiruma T, Kunisada T, Matsumine A, Susa M, Nakayama R, Nishimoto K, Kikuta K, Horiuchi K, Kawai A
- Journal Title
  
  BMC Cancer
  
  Volume: 16 Issue: 1 Pages: 479-479
- DOI
  10.1186/s12885-016-2511-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-26293342, KAKENHI-PROJECT-15K20017, KAKENHI-PROJECT-16K10862, KAKENHI-PROJECT-16K10874
[Presentation] 骨軟部肉腫PDXモデルの樹立とPDXを基盤とした治療実験、病態解析2023
- Author(s)
  宮城洋平、大津敬、笠島理加、北河徳彦、鷲見公太、横瀬智之、比留間徹、廣島幸彦
- Organizer
  第6回日本サルコーマ治療研究学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K09661
[Presentation] 肉腫患者由来ゼノグラフトのRNA発現解析2020
- Author(s)
  大津敬、笠島理加、比留間徹、宮城洋平、他8名
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K09661
[Presentation] 骨肉腫における予後予測ノモグラムの開発と外的妥当性の検証2016
- Author(s)
  小倉浩一、藤原智洋、康永秀生、松居宏樹、JeonDae-Geun,平賀博明、石井猛、米本司、鴨田博人、尾崎敏文、小澤栄史、西田佳弘、森岡秀夫、比留間徹、角永茂樹、上田孝文、荒木信人、中紀文、津田祐輔、河野博隆、川井章
- Organizer
  第89回日本整形外科学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-16H02676
[]

1. Sato Shinya (30464564)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. 星野大輔 (30571434)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 鷲見公太 (30716733)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. Matsuda Koichi (90401257)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 中村卓郎 (00180373)

# of Collaborated Projects: 1 results

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6. 中山タラントロバート (00365298)

# of Collaborated Projects: 1 results

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7. 竹中聡 (00588379)

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8. 高阪真路 (00627119)

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9. 松本嘉寛 (10346794)

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25. 西田佳弘 (50332698)

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26. 中川英刀 (50361621)

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27. 平田真 (50401071)

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28. 米本司 (50506318)

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29. 馬場一郎 (60330073)

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30. 小田義直 (70291515)

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31. 末原義之 (70509405)

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32. 國定俊之 (80346428)

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33. 山田聡 (80405208)

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34. 相羽久輝 (70793834)

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35. 松原大祐 (80415554)

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36. 川井章 (90252965)

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37. 筑紫聡 (90378109)

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38. 山口類 (90380675)

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39. 綿貫宗則 (90451575)

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42. 中紀文 (90601964)

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44. 五嶋孝博 (20272544)

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45. 岩田慎太郎 (90549685)

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46. 宮城洋平 (00254194)

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47. 大津敬 (10270696)

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48. 笠島理加 (20630875)

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49. 国定俊之

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HIRUMA Toru 比留間 徹

Research Projects

Research Products

Co-Researchers

Investigation of the suppression mechanism of bone marrow adipocyte-derived adiponectin on bone metastatic cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of adipocyte-derived hormones/extracellular vesicles on bone-metastasized cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of therapeutic strategies for DDLS with CDK4 inhibitor in PDXPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of diagnostic biomarker and novel fusion genes of bone and soft tissue sarcoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Bone marrow adipocytes induce cancer‐associated fibroblasts and immune evasion, enhancing invasion and drug resistance2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Histological markers, sickle-shaped blood vessels, myxoid area, and infiltrating growth pattern help stratify the prognosis of patients with myxofibrosarcoma/undifferentiated sarcoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Differential diagnosis of lipoma and atypical lipomatous tumor/well‐differentiated liposarcoma by cytological analysis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficacy of Trabectedin in Patients with Advanced Translocation‐Related Sarcomas: Pooled Analysis of Two Phase II Studies2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Results of sub-analysis of a phase 2 study on trabectedin treatment for extraskeletal myxoid chondrosarcoma and mesenchymal chondrosarcoma.2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] 骨軟部肉腫PDXモデルの樹立とPDXを基盤とした治療実験、病態解析2023

Author(s)

Organizer

Data Source

[Presentation] 肉腫患者由来ゼノグラフトのRNA発現解析2020

Author(s)

Organizer

Data Source

[Presentation] 骨肉腫における予後予測ノモグラムの開発と外的妥当性の検証2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[]

HIRUMA Toru 比留間徹