Nagaoka Hitoshi 長岡仁

… Alternative Names

長岡仁ナガオカヒトシ

NAGAOKA Hitoshi 長岡仁

Less

Researcher Number	20270647
Other IDs
Affiliation (Current)	2025: 岐阜大学, 大学院医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 岐阜大学, 大学院医学系研究科, 教授 2016: 岐阜大学, 大学院医学系研究科, 教授 2015: 京都大学, 医学研究科, 准教授 2011 – 2015: 岐阜大学, 医学(系)研究科(研究院), 教授 2010 – 2011: 岐阜大学, 医学系研究科, 教授 … More 2009: 岐阜大学, 医学研究科, 教授 2007 – 2009: Kyoto University, 医学研究科, 准教授 2006: 京都大学, 医学研究科, 講師 2005: Kyoto University, Graduate school of medicine, lecturer, 医学研究科, 寄付講座講師 2002 – 2004: 京都大学, 医学研究科, 講師 1994 – 1996: 国立予防衛生研究所, 免疫部, 研究員 Less
Review Section/Research Field	Principal Investigator General medical chemistry / Biological Sciences / Immunology / Basic Section 48040:Medical biochemistry-related / Biological Sciences Except Principal Investigator Biological Sciences / Basic Section 49010:Pathological biochemistry-related / Immunology
Keywords	Principal Investigator AID / 遺伝子 / 抗体遺伝子 / 体細胞突然変異 / 免疫 / 高IgM症候群 / クラススイッチ組み換え / CD43 / 遺伝子組換え / リンパ球 … More / 免疫学 / ゲノム / 細胞内局在 / 人工遺伝子 / 細胞分裂 / DNA組換え / dCas9 / TN3 resolvase / 転写制御 / 形質細胞種 / IRF4 / subcellular localization / hyper IgM syndrome / immunoglobulin gene / somatic hypermutation / class switch recombination / 高IqM症候群 / B cell dynamics / lgG antibodies / lgM antibodies / immune response / CD43 transgenic mice / cell cycle regulation / B cell survival / 細胞生存維持 / Cre-loxPシステム / CD43ゲノム遺伝子 / ターゲッティング / トランスジェニックマウス / 細胞周期 / B細胞 / ホモ遺伝子強発現マウス / IgMb抗体産生 / CD43強発現マウス / 細胞内相互作用 / B細胞dynamics / IgG抗体産生 / IgM抗体産生 / 免疫反応 / CD43トランスジェニックマウス / 細胞周期調節 / B細胞生存維持 / DNA脱メチル化 / 再生医学 / ゲノム医科学 / 生体分子医学 / 細胞分化 / 転写因子 / 発現制御 / リンパ球分化 / DNA / ワクチン / 感染症 / 抗体 / 発がん / クラススイッチ組換え / 発現調節 / 核酸 / 突然変異 / 癌 / S領域 / シチジンデアミナーゼ / 補助因子 … More Except Principal Investigator CD40 / Bリンパ球 / RNA編集 / 体細胞突然変異 / MAPキナーゼ / 高親和性B細胞 / 体細胞超変異 / 細胞周期 / 体細胞点変異 / B細胞 / 自己免疫疾患 / SLE / RhoGEF / FACT複合体 / 大規模シークエンス / 免疫帰国 / 獲得免疫 / 組換え / DNA切断 / DNA修復 / クラススイッチ組換え / antigen presentation / somatic hypermutation / cell cycle / germinal center / TRAF / MAP kinase / primary follicles / 免疫グロブリン遺伝子 / 記憶Bリンパ球 / centrocyte / centroblast / 一次免疫反応 / 抗原提示機能 / 細胞増殖 / 胚中心 / 一次濾胞B細胞 / 癌 / ゲノム / 抗体 / 免役学 / マイクロアレイ法 / 免疫沈降法 / ウラシルDNAグリコシラーゼ / クラススイッチ / B7-2 / error prone DNA repair / V_H遺伝子 / 胚中心B細胞 / VpreB-3 / 代替L鎖 / CD43 / 記憶細胞 / Germinal Center(胚中心) Less

SWEFタンパク質の時間的空間的制御による免疫記憶形成機構の解明
- Principal Investigator
  
  佐藤克哉
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Gifu University
細胞分裂数を記録する人工遺伝子の開発Principal Investigator
- Principal Investigator
  
  長岡仁
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Gifu University
Role of cytidine deaminase in cell reprograming processPrincipal Investigator
- Principal Investigator
  
  Nagaoka Hitoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Gifu University
Ｂリンパ球終末分化機構の解明Principal Investigator
- Principal Investigator
  
  長岡仁
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu University
Analysis of AID expression by a novel Cre-based in vivo gene manipulation system.Principal Investigator
- Principal Investigator
  
  NAGAOKA Hitoshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Gifu University
Mechanism for genome instability by activation induced cytidine deaminase induced-reduction of topoisomerase1
- Principal Investigator
  
  HONJO Tasuku
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Molecular mechanisms for class switch recombination and somatic hypermutation of immunoglobulin genesPrincipal Investigator
- Principal Investigator
  
  NAGAOKA Hitoshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Gifu University
  Kyoto University
抗体遺伝子体細胞突然変異の標的特異性とその破綻Principal Investigator
- Principal Investigator
  
  長岡仁
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
AID-dependent genetic alteration mechanism to generate antigen-specific antibodies
- Principal Investigator
  
  HONJO Tasuku
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
高親和性抗体産生の分子機序Principal Investigator
- Principal Investigator
  
  長岡仁
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
The role of AID in class switch recombination and somatic hypermutation of immunoglobulin genesPrincipal Investigator
- Principal Investigator
  
  NAGAOKA Hitoshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
抗体遺伝子クラススイッチ組み換え及び体細胞突然変異におけるに於けるAIDの役割Principal Investigator
- Principal Investigator
  
  長岡仁
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Kyoto University
B細胞分化・成熟分子機構の解明及びその制御
- Principal Investigator
  
  竹森利忠
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  国立予防衛生研究所
Mechanism of B cell maturaion
- Principal Investigator
  
  TAKEMORI Toshitada
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  National Institute of Health
B細胞分化・成熟分子機構の解明およびその制御
- Principal Investigator
  
  TAKEMORI Toshitada
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  国立予防衛生研究所
Functional role of CD43 in immune systemPrincipal Investigator
- Principal Investigator
  
  NAGAOKA Hitoshi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  National Institute of Health of Japan

All 2024 2017 2016 2015 2014 2013 2012 2011 2010 2009 2007 2005 Other

All Journal Article Presentation Book

[Book] Molecular Mechanisms of AID Function at Molecular Biology of the B cells, 2nd edition2014
- Author(s)
  Nasim A Begum, Hitoshi Nagaoka, Maki Kobayashi, Tasuku Honjo
- Total Pages
  553
- Publisher
  Academic Press
- Data Source
  KAKENHI-PROJECT-26460363
[Book] Discovery of activation-induced cytidine deaminase, the engraver of antibody memory. Vol.942007
- Author(s)
  Muramatsu, M., Nagaoka, H., Shinkura, R., Begum, N.A., Honjo, T.
- Publisher
  ELSEVIER, Adv. Immunol.
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] Assessing Interferon Regulatory Factor 4 Complex Formation: Differential Behavior of Homocomplexes Versus Heterocomplexes Induced by Mutations2024
- Author(s)
  Li Yupeng、Hirano Setoka、Sato Katsuya、Osawa Masatake、Nagaoka Hitoshi
- Journal Title
  
  Biochemistry
  
  Volume: 63 Issue: 6 Pages: 767-776
- DOI
  10.1021/acs.biochem.3c00512
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06898, KAKENHI-PROJECT-22K08377, KAKENHI-PROJECT-23K06411
[Journal Article] M2-like macrophage polarization in high lactic acid-producing head and neck cancer.2017
- Author(s)
  Ohashi, T, Aoki, M, Tomita, H, Akazawa, T, Sato, K, Kuze, B, Mizuta, K, Hara, A, Nagaoka, H, Inoue, N, Ito, Y
- Journal Title
  
  Cancer Sci
  
  Volume: 印刷中 Issue: 6 Pages: 1128-1134
- DOI
  10.1111/cas.13244
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460363, KAKENHI-PROJECT-15K19005, KAKENHI-PROJECT-17K16902, KAKENHI-PROJECT-16H04703
[Journal Article] Four-and-a-half LIM Domains 1 (FHL1) Protein Interacts with the Rho Guanine Nucleotide Exchange Factor PLEKHG2/FLJ00018 and Regulates Cell Morphogenesis.2016
- Author(s)
  Sato, K., Kimura, M., Sugiyama, K., Nishikawa, M., Okano, Y., Nagaoka, H., Nagase, T., Kitade, Y., and Ueda, H.
- Journal Title
  
  J Biol Chem
  
  Volume: 291 Issue: 48 Pages: 25227-25238
- DOI
  10.1074/jbc.m116.759571
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460363, KAKENHI-PROJECT-15K07927, KAKENHI-PROJECT-15K19005
[Journal Article] Identification of a Rho family specificguanine nucleotide exchange factorFLJ00018, as a novel actin-bindingprotein2013
- Author(s)
  Sato, K., Handa, H., Kimura, M., Okano,Y., Nagaoka, H., Nagase, T., Sugiyama,T., Kitade, Y., and Ueda, H.
- Journal Title
  
  Cell. Signal.
  
  Volume: 25 Issue: 1 Pages: 41-49
- DOI
  10.1016/j.cellsig.2012.09.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590331, KAKENHI-PROJECT-23590073, KAKENHI-PROJECT-23659151, KAKENHI-PUBLICLY-23118513
[Journal Article] In vivo analysis of Aicda gene regulation: a critical balance between upstream enhancers and intronic silencers governs appropriate expression2013
- Author(s)
  Le Thi Huong, Maki Kobayashi,et al
- Journal Title
  
  PLoSONE
  
  Volume: vol.8 Issue: 4 Pages: e61433-e61433
- DOI
  10.1371/journal.pone.0061433
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570169, KAKENHI-PROJECT-23659151, KAKENHI-PROJECT-25440007
[Journal Article] The AID Dilemma: Infection, or Cancer?2013
- Author(s)
  Tasuku Honjo, Maki Kobayashi, Nasim Begum, Ai Kotani, Somayeh Sabour and Hitoshi Nagaoka
- Journal Title
  
  Adv Cancer Res
  
  Volume: vol.113 Pages: 1-44
- DOI
  10.1016/b978-0-12-394280-7.00001-4
- ISBN
  9780123942807
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570169, KAKENHI-PUBLICLY-23118513, KAKENHI-PROJECT-23659151, KAKENHI-PROJECT-24590352, KAKENHI-PROJECT-22000015
[Journal Article] Mitotic catastrophe and cell deathinduced by depletion of centrosomalproteins2013
- Author(s)
  Kimura, M., Yoshioka, T., Saio, M.,Banno, Y., Nagaoka, H., and Okano, Y
- Journal Title
  
  Cell Death Dis
  
  Volume: 4 Issue: 4 Pages: e603-e603
- DOI
  10.1038/cddis.2013.108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590331, KAKENHI-PROJECT-23659151
[Journal Article] Imatinib mesylate directly impairs class switch recombination through downregulation of AID : its potential efficacy as an AID suppressor2012
- Author(s)
  Kawamata, T., Lu, J., Sato, T., Tanaka, M., Nagaoka, H., Agata, Y., Toyoshima, T., Yokoyama, K., Oyaizu, N., Nakamura, N., Ando, K., Tojo, A., and Kotani, A.
- Journal Title
  
  Blood
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590277
[Journal Article] Imatinib mesylate directly impairs class switch recombination through downregulation of AID.2012
- Author(s)
  Kawamata T, Lu J, Sato T, Tanaka M, Nagaoka H, Agata Y, Toyoshima T, Yokoyama K, Oyaizu N, Nakamura N, Ando K, Tojo A, Kotani A
- Journal Title
  
  Blood
  
  Volume: 119 Issue: 13 Pages: 3123-3127
- DOI
  10.1182/blood-2011-01-327932
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22021021, KAKENHI-PROJECT-22790904, KAKENHI-PUBLICLY-23118507, KAKENHI-PUBLICLY-23118513, KAKENHI-PUBLICLY-23118515, KAKENHI-PROJECT-23390068, KAKENHI-PROJECT-23591373, KAKENHI-PROJECT-23659151, KAKENHI-PROJECT-24390248
[Journal Article] The AID Dilemma : Infection, or Cancer2012
- Author(s)
  Honjo, T., Kobayashi, M., Begum, N., Kotani, A., Sabouri, S., and Nagaoka, H.
- Journal Title
  
  Adv Cancer Res
  
  Volume: 113 Pages: 1-44
- Data Source
  KAKENHI-PROJECT-20590277
[Journal Article] Activation-Induced Cytidine Deaminase Expression in CD4 T Cells is Associated with a Unique IL-10-Producing Subset that Increases with Age2011
- Author(s)
  Qin, H., 他
- Journal Title
  
  PLoS One
  
  Volume: 6(電子出版) Issue: 12 Pages: e29141-e29141
- DOI
  10.1371/journal.pone.0029141
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23118513, KAKENHI-PROJECT-23659151
[Journal Article] Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation2011
- Author(s)
  Okazaki IM, Okawa K, Kobayashi M, Yoshikawa K, Kawamoto S, Nagaoka H, Shinkura R, Kitawaki Y, Taniguchi H, Natsume T, Iemura S, and Honjo T
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 108 Issue: 19 Pages: 920-925
- DOI
  10.1073/pnas.1104423108
- NAID
  120003163668
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370042, KAKENHI-PUBLICLY-23118513, KAKENHI-PROJECT-23659151
[Journal Article] Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation2011
- Author(s)
  Okazaki, I. M., Okawa, K., Kobayashi, M., Yoshikawa, K., Kawamoto, S., Nagaoka, H., Shinkura, R., Kitawaki, Y., Taniguchi, H., Natsume, T., Iemura, S., and Honjo, T.
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 108 Pages: 7920-7925
- NAID
  120003163668
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590277
[Journal Article] Activation-Induced Cytidine Deaminase Expression in CD4 T Cells is Associated with a Unique IL-10-Producing Subset that Increases with Age2011
- Author(s)
  Qin, H., Suzuki, K., Nakata, M., Chikuma, S., Izumi, N., Thi Huong, L., Maruya, M., Fagarasan, S., Busslinger, M., Honjo, T., and Nagaoka, H.
- Journal Title
  
  PLoS One 6
  
  Volume: e29141
- NAID
  120003726138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590277
[Journal Article] Preventing AID, a physiological mutator, from deleterious activation : regulation of the genomic instability that is associated with antibody diversity.2010
- Author(s)
  Nagaoka, H, 他
- Journal Title
  
  Int Immunol
  
  Volume: 22 Pages: 227-235
- NAID
  10027391988
- Data Source
  KAKENHI-PROJECT-20590277
[Journal Article] Preventing AID, a physiological mutator, from deleterious activation : regulation of the genomic instability that is associated with antibody diversity.2010
- Author(s)
  Nagaoka, H., et al.
- Journal Title
  
  Int.Immunol.
  
  Volume: 22(Review) Pages: 227-235
- NAID
  10027391988
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22000015
[Journal Article] Preventing AID, a physiological mutator, from deleterious activation : regulation of the genomic instability that is associated with antibody diversity2010
- Author(s)
  Nagaoka, H., Tran, T. H., Kobayashi, M., Aida, M., and Honjo, T.
- Journal Title
  
  Int Immunol
  
  Volume: 22 Pages: 227-235
- NAID
  10027391988
- Data Source
  KAKENHI-PROJECT-20590277
[Journal Article] Preventing AID, a physiological mutator, from deleterious activation : regulation of the genomic instability that is associated with antibody diversity2010
- Author(s)
  Nagaoka, H., 他
- Journal Title
  
  Int Immunol
  
  Volume: 22(4) Pages: 227-235
- NAID
  10027391988
- Data Source
  KAKENHI-PROJECT-20590277
[Journal Article] B cell-specific and stimulation-responsive enhancers derepress the Aicda gene by overcoming the effects of silencers.2010
- Author(s)
  Tran, T., Nakata, M., Suzuki, K., Begum, N.A., Shinkura, R., Fagarasan, S., Honjo, T., Nagaoka, H.
- Journal Title
  
  Nature Immunol. 11
  
  Pages: 148-154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers2010
- Author(s)
  Tran, T. H., Nakata, M., Suzuki, K., Begum, N. A., Shinkura, R., Fagarasan, S., Honjo, T., and Nagaoka, H.
- Journal Title
  
  Nat Immunol
  
  Volume: 11 Pages: 148-154
- NAID
  120001741673
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590277
[Journal Article] AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model2010
- Author(s)
  Komeno, Y., Kitaura, J., Watanabe-Okochi, N., Kato, N., Oki, T., Nakahara, F., Harada, Y., Harada, H., Shinkura, R., Nagaoka, H., Hayashi, Y., Honjo, T., and Kitamura, T.
- Journal Title
  
  Leukemia
  
  Volume: 24 Pages: 1018-1024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590277
[Journal Article] AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model.2010
- Author(s)
  Komeno, Y., Kitaura, J., Watanabe-Okochi, N., Kato, N., Oki, T., Nakahara, F., Harada, Y., Harada, H., Shinkura, R., Nagaoka, H., Hayashi, Y., Honjo, T., Kitamura, T.
- Journal Title
  
  Leukemia 24
  
  Pages: 1018-1024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] Preventing AID, a physiological mutator, from deleterious activation : regulation of the genomic instability that is associated with antibody diversity. (Review)2010
- Author(s)
  Nagaoka, H., et al.
- Journal Title
  
  Int.Immunol. 22
  
  Pages: 227-235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] Molecular mechanism for generation of antibody memory2009
- Author(s)
  Shivarov, V., Shinkura, R., Doi, T., Begum, N. A., Nagaoka, H., Okazaki, I. M., Ito, S., Nonaka, T., Kinoshita, K., and Honjo, T.
- Journal Title
  
  Philos Trans R Soc Lond B Biol Sci
  
  Volume: 364 Pages: 569-575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590277
[Journal Article] Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobilin genes.2009
- Author(s)
  Sabouri, Z., Okazaki, I., Shinkura, R., Begum, N.A., Nagaoka, H., Tsuchimoto, D., Nakabeppu, Y., Honjo, T.
- Journal Title
  
  Int.Immunol. 21
  
  Pages: 947-955
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] The C-terminal region of AID is responsible for a novel function other than DNA cleavage in class switch recombination.2009
- Author(s)
  Doi, T., Kato, L., Ito, S., Shinkura, R., Wei, M., Nagaoka, H., Wang, J., Honjo, T.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 106
  
  Pages: 2758-2763
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination2009
- Author(s)
  Doi, T., Kato, L., Ito, S., Shinkura, R., Wei, M., Nagaoka, H., Wang, J., and Honjo, T.
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 106 Pages: 2758-2763
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590277
[Journal Article] AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination.2009
- Author(s)
  Kobayashi, M., Aida, M., Nagaoka, H., Begum, N.A., Kitawaki, Y., Nakata, M., Stanlie, A., Doi, T., Kato, L., Okazaki, I., Shinkura R., Muramatsu, M., Kinoshita, K., Honjo, T.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 106
  
  Pages: 22375-22380
- NAID
  120001749564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] Further evidence for involvement of a non-canonical function of uracil DNA glycosylase in class switch recombination.2009
- Author(s)
  Begum, N.A., Stanlie, A., Doi, T., Sasaki, Y., Jin, H.W., Kim, Y.S., Nagaoka, H., Honjo, T.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 106
  
  Pages: 2752-2757
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination2009
- Author(s)
  Begum, N. A., Stanlie, A., Doi, T., Sasaki, Y., Jin, H. W., Kim, Y. S., Nagaoka, H., and Honjo, T.
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 106 Pages: 2752-2757
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590277
[Journal Article] Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes2009
- Author(s)
  Sabouri, Z., Okazaki, I. M., Shinkura, R., Begum, N., Nagaoka, H., Tsuchimoto, D., Nakabeppu, Y., and Honjo, T.
- Journal Title
  
  Int Immunol
  
  Volume: 21 Pages: 947-955
- NAID
  10025387710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590277
[Journal Article] AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination2009
- Author(s)
  Kobayashi, M., Aida, M., Nagaoka, H., Begum, N. A., Kitawaki, Y., Nakata, M., Stanlie, A., Doi, T., Kato, L., Okazaki, I. M., Shinkura, R., Muramatsu, M., Kinoshita, K., and Honjo, T.
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 106 Pages: 22375-22380
- NAID
  120001749564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590277
[Journal Article] Requirement of non-canonical activity of uracil DNA glycosylase for class switch recombination.2007
- Author(s)
  Begum, N.A., Izumi, N., Nishikori, M., Nagaoka, H., Shinkura, R., Honjo, T.
- Journal Title
  
  J.Biol.Chem. 282
  
  Pages: 731-742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] Discovery of activation-induced cytidine deaminase, the engraver of antibody memory.2007
- Author(s)
  Muramatsu, M., Nagaoka, H., Shinkura, R., Begum, N.A., Honjo, T.
- Journal Title
  
  Adv.Immunol. 94
  
  Pages: 1-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] DNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylase2005
- Author(s)
  Nagaoka, H.
- Journal Title
  
  Proc Natl Acad Sci USA 102
  
  Pages: 2022-2027
- Data Source
  KAKENHI-PROJECT-16590225
[Journal Article] DNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylase2005
- Author(s)
  Nagaoka, H.
- Journal Title
  
  Proc Natl Acad So U S A 102
  
  Pages: 2022-2027
- Data Source
  KAKENHI-PROJECT-16017247
[Journal Article] DNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylase2005
- Author(s)
  Nagaoka, H. et al.
- Journal Title
  
  Proc Natl Acad Sci U S A 102
  
  Pages: 2022-7
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590225
[Journal Article] AID to overcome the limitations of genomic information.2005
- Author(s)
  Honjo, T., Nagaoka, H., Shinkura, R., Muramatsu, M.
- Journal Title
  
  Nature Immunol. 6
  
  Pages: 655-661
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] DNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylase.2005
- Author(s)
  Nagaoka, H.
- Journal Title
  
  Proc Natl Acad Sci U S A 102
  
  Pages: 2022-2027
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590225
[Presentation] Evaluation of function of transcription factors, Batf and HoxC4, in Aicda gene regulation2015
- Author(s)
  Katsuya Sato, Hitoshi Nagaoka
- Organizer
  日本免疫学会総会・学術集会
- Place of Presentation
  札幌市
- Year and Date
  2015-11-20
- Data Source
  KAKENHI-PROJECT-26460363
[Presentation] CRISPR/CAS9を用いた抗体遺伝子改変酵素AIDの発現制御機構の解析2015
- Author(s)
  堀賢一郎、佐藤克哉、金山佳史、安田一、長屋州宣、長岡仁
- Organizer
  第88回日本生化学会大会
- Place of Presentation
  神戸市
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-26460363
[Presentation] In vivo analysis of Aicda gene regulation: critical balance between upstream enhancer and intronic repressor for the appropriate expression2013
- Author(s)
  Hitoshi Nagaoka　他6名
- Organizer
  15th International Congress of Immunology
- Place of Presentation
  Milan, Italy
- Year and Date
  2013-08-22
- Data Source
  KAKENHI-PUBLICLY-23118513
[Presentation] In vivo analysis of Aicda gene regulation : critical balance between upstream enhancer and intronic repressor for the appropriate expression2013
- Author(s)
  Nagaoka, H., et al.
- Organizer
  15th International Congress of Immunology
- Place of Presentation
  Milan, Italy
- Year and Date
  2013-08-25
- Data Source
  KAKENHI-PROJECT-23659151
[Presentation] n vivo analysis of Aicda gene regulation: critical balance between upstream enhancer and intronic repressor for the appropriate expression2013
- Author(s)
  L. Huong, M. Kobayashi, M. Nakata, G. Shioi, H. Miyachi, T. Honjo, H. Nagaoka
- Organizer
  15th International Congress of Immunology
- Place of Presentation
  Milan, Italy
- Data Source
  KAKENHI-PROJECT-23659151
[Presentation] In vivo analysis of Aicda gene regulation: critical balance between upstream enhancer and intronic repressor for the appropriate expression.2013
- Author(s)
  L. Huong, M. Kobayashi, M. Nakata, G. Shioi, H. Miyachi, T. Honjo, H. Nagaoka
- Organizer
  15th international congress of immunology
- Place of Presentation
  Milan, Italy
- Data Source
  KAKENHI-PROJECT-23659151
[Presentation] Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL- 10-producing subset that increases with age2012
- Author(s)
  Nagaoka, H, et al.
- Organizer
  Genetic and Epigenetic Control of Cell Fate
- Place of Presentation
  京都市
- Year and Date
  2012-11-06
- Data Source
  KAKENHI-PROJECT-23659151
[Presentation] Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age2012
- Author(s)
  Hongyan Qin, Keiichiro Suzuki, Mikiyo Nakata, Shunsuke Chikuma, Nakako Izumi, Le Thi Huong, Mikako Maruya, Sidonia Fagarasan, Meinrad Busslinger, Tasuku Honjo and Hitoshi Nagaoka
- Organizer
  Genetic and Epigenetic Control of Cell Fate
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-23659151
[Presentation] Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age2012
- Author(s)
  Hitoshi Nagaoka　他１０名
- Organizer
  Genetic and Epigenetic Control of Cell Fate
- Place of Presentation
  京都府京都市左京区岩倉幡枝町1092-2　グランドプリンスホテル京都
- Year and Date
  2012-11-06
- Data Source
  KAKENHI-PUBLICLY-23118513
[Presentation] AID遺伝子が発現するT細胞サブセットはIL-10を発現し加齢とともに蓄積するユニークなサブセットである2011
- Author(s)
  長岡仁, 他
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都市
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PUBLICLY-23118513
[Presentation] AID 遺伝子が発現するT細胞サブセットはIL-10 を発現し加齢とともに蓄積するユニークなサブセットである2011
- Author(s)
  長岡仁, 他
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都市
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-23659151
[Presentation] AID遺伝子が発現するT細胞サブセットはIL-10を発現し加齢とともに蓄積するユニークなサブセットである2011
- Author(s)
  長岡仁, 他
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都市
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-20590277
[Presentation] Transcriptional regulation of Aicda, encoding activation-induced cytidine deaminase2010
- Author(s)
  長岡仁, 他
- Organizer
  第14回国際免疫学会議
- Place of Presentation
  神戸市
- Year and Date
  2010-08-26
- Data Source
  KAKENHI-PROJECT-20590277
[Presentation] AID遺伝子が発現するT細胞サブセットはIL-10を発現し加齢とともに蓄積するユニークなサブセットである
- Author(s)
  長岡　仁.　他
- Organizer
  第８４回日本生化学会大会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-23659151

1. TAKEMORI Toshitada (60114295)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. KIMOTO Hiroshi (20225080)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. BEGUM Nasim (80362507)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
4. TOKUHISA Takeshi (20134364)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. 佐藤克哉 (60733508)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
6. MISAWA Yukiko (10250185)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. HONJO Tasuku (80090504)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
8. SHINKURA Reiko (50362471)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. KOBAYASHI Maki (20400690)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
10. NISHIKORI Momoko (60378635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. CHON Il-Mi (50452339)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. DOI Tomomitsu (70437218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. ADACHI Yoshihiro (20291122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KASHIWADA Masaki (20270639)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 木村正志 (40260575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
16. 岡野幸雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 新蔵礼子

# of Collaborated Projects: 0 results

# of Collaborated Products: 9 results
18. 縣保年

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 谷口寿章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nagaoka Hitoshi 長岡 仁

長岡 仁 ナガオカ ヒトシ

NAGAOKA Hitoshi 長岡 仁

Research Projects

Research Products

Co-Researchers

SWEFタンパク質の時間的空間的制御による免疫記憶形成機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

細胞分裂数を記録する人工遺伝子の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of cytidine deaminase in cell reprograming processPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Ｂリンパ球終末分化機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of AID expression by a novel Cre-based in vivo gene manipulation system.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism for genome instability by activation induced cytidine deaminase induced-reduction of topoisomerase1

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms for class switch recombination and somatic hypermutation of immunoglobulin genesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

抗体遺伝子体細胞突然変異の標的特異性とその破綻Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

AID-dependent genetic alteration mechanism to generate antigen-specific antibodies

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

高親和性抗体産生の分子機序Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of AID in class switch recombination and somatic hypermutation of immunoglobulin genesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

抗体遺伝子クラススイッチ組み換え及び体細胞突然変異におけるに於けるAIDの役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

B細胞分化・成熟分子機構の解明及びその制御

Principal Investigator

Nagaoka Hitoshi 長岡仁

長岡仁ナガオカヒトシ

NAGAOKA Hitoshi 長岡仁