Kumagai Hidetoshi 熊谷英敏

… Alternative Names

KUMAGAI Hidetoshi 熊谷英敏

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Researcher Number	20281008
Affiliation (Current)	2025: 東京大学, 医学部附属病院, 特任研究員
Affiliation (based on the past Project Information) *help	2015 – 2019: 東京大学, 医学部附属病院, 特任助教 2014 – 2015: 東京大学, 医学部附属病院, 助教 1996 – 1997: NIIGATA UNIVERSITY SCHOOL OF MEDICINE RESEARCH ASSOCIATE, 医学部, 助手
Review Section/Research Field	Principal Investigator General pharmacology Except Principal Investigator General pharmacology / Gastroenterology / Organ-based internal medicine and related fields / Cardiovascular medicine / General medical chemistry / 医薬分子機能学
Keywords	Principal Investigator 心不全治療薬 / ハイスループットスクリーニング / 選択的阻害剤 / NFAT / 生理活性ペプチド / β-アレスチン / Gタンパク質 / GPCR Except Principal Investigator NF-Y / 常在性腸内細菌叢 … More / D8S508 / スクアレン・エポキシダーゼ / コレステロール / 生理活性 / Gタンパク質共役型受容体 / 下部消化管 / 消化器内科 / 内科 / 腸管幹細胞 / Wntシグナル / SRE / バイオセンサー / スクリーニング / 高脂血症 / 動脈硬化 / スクアレン / 阻害剤 / スクアレン・エポキシダーゼ(SE) / 腸管イントラネット / 新規生理活性代謝産物 / プロスタグランディン / 炎症・免疫 / H-PGDS阻害薬 / プロスタグランディンD2 / 心筋線維化 / 自己免疫性心筋炎 / 細胞・組織 / 循環器・高血圧 / シグナル伝達 / CXCR7遺伝子欠損マウス / CXCR7 / 心不全 / 再生医学 / 生理活性代謝産物 / 低分子代謝産物 / 苦味受容体 / R-spondin代替え低分子化合物 / 低分子化合物ライブラリー / 抗癌剤 / R-spondin / membrane binding domain / transcription factor / SREBP (sterol regulatory element binding protein) / transcriptional regulation / cholesterol / lanosterol synthase / squalene epoxidase / 染色体8 / プロモーター領域 / 発現調節 / HeLa細胞 / 遺伝子構造(イントロン-エクソン構成) / 転写調整 / 膜結合領域 / 転写因子 / SREBP / 転写調節 / ラノステロール合成酵素 / chromosome 8 q24.13 / gene expression / LDL-receptor / HMG-CoA reductase / benzophenone derivatives / squalene epoxidase(SE) / 染色体8q24.13 / 遺伝子発現 / LDL-レセプター / HMG-CoA還元酵素 / ベンゾフェノン誘導体 / エポキシダーゼ(SE) / Growth inhibition / Squalene synthase (SS) / Antifungal drug / Cloning / Inhibitor / Yeast transformant / Lanosterol synthase (LS) / Squalene epoxidase (SE) / スクアレンエポキシダーゼ / 生育阻害 / スクアレン合成酵素(SS) / 抗真菌剤 / クローニング / 酵母トランスフォーマント / ラノステロール合成酵素(LS) Less

Screening for selective NFATc4 inhibitors to develop a drug of heart failurePrincipal Investigator
- Principal Investigator
  
  Kumagai Hidetoshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  The University of Tokyo
exploratory research of gut microbiota-derived metabolites
- Principal Investigator
  
  Fujishiro Mitsuhiro
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Organ-based internal medicine and related fields
- Research Institution
  Nagoya University
  The University of Tokyo
Screening for gut microbiota-derived metabolites that stimulate intestinal stem cells
- Principal Investigator
  
  Fujishiro Mitsuhiro
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
The role of CXCR7 in failing heart
- Principal Investigator
  
  Harada Mutsuo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  The University of Tokyo
Regulation of cardiac remodeling by inhibiting the PGD2-mediated inflammatory response.
- Principal Investigator
  
  Ikeda Yuichi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  The University of Tokyo
Development of anti-cancer agents targeting R-spondin-LGR4/5/6-ZNRF3/RNF43 axis
- Principal Investigator
  
  Fujishiro Mitsuhiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Screening for gut microbiota-derived metabolites that activate bitter taste receptors
- Principal Investigator
  
  Morita Hiroyuki
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  The University of Tokyo
Screening for peptide ligands that activate beta-arrestin biasd cell signaling of orphan GPCRsPrincipal Investigator
- Principal Investigator
  
  Kumagai Hidetoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  The University of Tokyo
Structure and Regulation of Cholesterol Biosynthesis
- Principal Investigator
  
  ONO Teruo
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Niigata University
Regulatory mechanism of Enzymes of Cholesterol Biosynthesis
- Principal Investigator
  
  ONO Teruo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Niigata University
REGULATION OF SQUALENE EPOXIDASE EXPRESSION AND THE ENZYME EVOLUTION
- Principal Investigator
  
  ONO Teruo
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  NIIGATA UNIVERSITY

All 2019 2018 2017 2016 2015

All Journal Article

[Journal Article] Novel computer-assisted diagnosis system for endoscopic disease activity in patients with ulcerative colitis2019
- Author(s)
  Ozawa Tsuyoshi、Ishihara Soichiro、Fujishiro Mitsuhiro、Saito Hiroaki、Kumagai Youichi、Shichijo Satoki、Aoyama Kazuharu、Tada Tomohiro
- Journal Title
  
  Gastrointestinal Endoscopy
  
  Volume: 89 Issue: 2 Pages: 416-421.e1
- DOI
  10.1016/j.gie.2018.10.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19673
[Journal Article] Corrigendum to “Enhancing endogenous adenosine A2A receptor signaling induces slow-wave sleep without affecting body temperature and cardiovascular function” [Neuropharmacology 144 (2019) 122?132]2019
- Author(s)
  Korkutata Mustafa、Saitoh Tsuyoshi、Cherasse Yoan、Ioka Shuji、Duo Feng、Qin Rujie、Murakoshi Nobuyuki、Fujii Shinya、Zhou Xuzhao、Sugiyama Fumihiro、Chen Jiang-Fan、Kumagai Hidetoshi、Nagase Hiroshi、Lazarus Michael
- Journal Title
  
  Neuropharmacology
  
  Volume: 153 Pages: 153-153
- DOI
  10.1016/j.neuropharm.2019.04.027
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08585
[Journal Article] Critical Role of SREBP-1c Large-VLDL Pathway in Environment-Induced Hypertriglyceridemia of Apo AV Deficiency2019
- Author(s)
  Takanashi M, Kimura T, Li C, Tanaka M, Matsuhashi A, Yoshida H, Noda A, Xu P, Takase S, Okazaki S, Iizuka Y, Kumagai H, Ikeda Y, Gotoda T, Takahashi M, Yagyu H, Ishibashi S, Yamauchi T, Kadowaki T, Liang G, Okazaki H.
- Journal Title
  
  Arteriosclerosis, Thrombosis, and Vascular Biology
  
  Volume: 39 Issue: 3 Pages: 373-386
- DOI
  10.1161/atvbaha.118.311931
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08585, KAKENHI-PROJECT-17K09858, KAKENHI-PROJECT-18K08504, KAKENHI-PROJECT-18H04053, KAKENHI-PROJECT-17K09867, KAKENHI-PROJECT-26000012
[Journal Article] Diagnostic outcomes of esophageal cancer by artificial intelligence using convolutional neural networks2019
- Author(s)
  Horie Yoshimasa、Yoshio Toshiyuki、Aoyama Kazuharu、Yoshimizu Shoichi、Horiuchi Yusuke、Ishiyama Akiyoshi、Hirasawa Toshiaki、Tsuchida Tomohiro、Ozawa Tsuyoshi、Ishihara Soichiro、Kumagai Youichi、Fujishiro Mitsuhiro、Maetani Iruru、Fujisaki Junko、Tada Tomohiro
- Journal Title
  
  Gastrointestinal Endoscopy
  
  Volume: 89 Issue: 1 Pages: 25-32
- DOI
  10.1016/j.gie.2018.07.037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19673
[Journal Article] Impact of Pathogenic FBN1 Variant Types on the Progression of Aortic Disease in Patients With Marfan Syndrome2018
- Author(s)
  Takeda N, Inuzuka R, Maemura S, Morita H, Nawata K, Fujita D, Taniguchi Y, Yamauchi H, Yagi H, Kato M, Nishimura H, Hirata Y, Ikeda Y, Kumagai H, Amiya E, Hara H, Fujiwara T, Akazawa H, Suzuki JI, Imai Y, Nagai R, Takamoto S, Hirata Y, Ono M, Komuro I.
- Journal Title
  
  Circulation: Genomic and Precision Medicine
  
  Volume: 11 Issue: 6
- DOI
  10.1161/circgen.117.002058
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08585, KAKENHI-PROJECT-17H04061, KAKENHI-PROJECT-16K10059, KAKENHI-PROJECT-17K19673, KAKENHI-PROJECT-18K08097
[Journal Article] A Novel Bioabsorbable Sheet That Delivers NF-κB Decoy Oligonucleotide Restrains Abdominal Aortic Aneurysm Development in Rats2018
- Author(s)
  Akimoto Shouta、Suzuki Jun-ichi、Aoyama Norio、Ikeuchi Ryota、Watanabe Hajime、Tsujimoto Hiroyuki、Wakayama Kouji、Kumagai Hidetoshi、Ikeda Yuichi、Akazawa Hiroshi、Komuro Issei
- Journal Title
  
  Int. Heart J.
  
  Volume: 59 Issue: 5 Pages: 1134-1141
- DOI
  10.1536/ihj.17-632
- NAID
  130007490504
- ISSN
  1349-2365, 1349-3299
- Year and Date
  2018-09-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08585, KAKENHI-PROJECT-17K19673, KAKENHI-PROJECT-18K08097
[Journal Article] Efficacy and safety of twice-daily rabeprazole maintenance therapy for patients with reflux esophagitis refractory to standard once-daily proton pump inhibitor: the Japan-based EXTEND study2018
- Author(s)
  Kinoshita Yoshikazu、Kato Mototsugu、Fujishiro Mitsuhiro、Masuyama Hironori、Nakata Ryo、Abe Hisanori、Kumagai Shinji、Fukushima Yasushi、Okubo Yoshiumi、Hojo Seiichiro、Kusano Motoyasu
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 53 Issue: 7 Pages: 834-844
- DOI
  10.1007/s00535-017-1417-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19673
[Journal Article] Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury2018
- Author(s)
  Hara H, Takeda N, Kondo M, Kubota M, Saito T, Maruyama J, Fujiwara T, Maemura S, Ito M, Naito AT, Harada M, Toko H, Nomura S, Kumagai H, Ikeda Y, Ueno H, Takimoto E, Akazawa H, Morita H, Aburatani H, Hata Y, Uchiyama M, Komuro I.
- Journal Title
  
  JACC: Basic to Translational Science
  
  Volume: 3 Issue: 5 Pages: 639-653
- DOI
  10.1016/j.jacbts.2018.07.005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08585, KAKENHI-PROJECT-18K06571, KAKENHI-PUBLICLY-18H05105, KAKENHI-PROJECT-17J05193, KAKENHI-PROJECT-17K19673, KAKENHI-PROJECT-17K15987, KAKENHI-PROJECT-19K07948, KAKENHI-PROJECT-18K08097
[Journal Article] Distinct variants affecting differential splicing of TGFBR1 exon 5 cause either Loeys?Dietz syndrome or multiple self-healing squamous epithelioma2018
- Author(s)
  Fujiwara Takayuki、Takeda Norifumi、Hara Hironori、Morita Hiroyuki、Kishihara Jun、Inuzuka Ryo、Yagi Hiroki、Maemura Sonoko、Toko Haruhiro、Harada Mutsuo、Ikeda Yuichi、Kumagai Hidetoshi、Nomura Seitaro、Takimoto Eiki、Akazawa Hiroshi、Ako Junya、Komuro Issei
- Journal Title
  
  European Journal of Human Genetics
  
  Volume: 26 Issue: 8 Pages: 1151-1158
- DOI
  10.1038/s41431-018-0127-1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08585, KAKENHI-PROJECT-17J05193, KAKENHI-PROJECT-16K10059, KAKENHI-PROJECT-17K19673, KAKENHI-PROJECT-18K08097
[Journal Article] Japanese Cardiovascular Disease Patients with Diabetes Mellitus Suffer Increased Tooth Loss in Comparison to Those without Diabetes Mellitus -A Cross-sectional Study2018
- Author(s)
  Aoyama Norio、Suzuki Jun-ichi、Kobayashi Naho、Hanatani Tomoya、Ashigaki Norihiko、Yoshida Asuka、Shiheido Yuka、Sato Hiroki、Kumagai Hidetoshi、Ikeda Yuichi、Akazawa Hiroshi、Komuro Issei、Minabe Masato、Izumi Yuichi、Isobe Mitsuaki
- Journal Title
  
  Intern. Med.
  
  Volume: 57 Issue: 6 Pages: 777-782
- DOI
  10.2169/internalmedicine.9578-17
- NAID
  130006507416
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17347, KAKENHI-PROJECT-16H05824, KAKENHI-PROJECT-17K08585, KAKENHI-PROJECT-18K08097
[Journal Article] A Periodontal pathogen Porphyromonas gingivalis deteriorates Isoproterenol-Induced myocardial remodeling in mice2017
- Author(s)
  Sato H, Suzuki JI, Aoyama N, Watanabe R, Kaneko M, Shiheido Y, Yoshida A, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Isobe M, Izumi Y
- Journal Title
  
  Hypertens Res.
  
  Volume: 40 Issue: 1 Pages: 35-40
- DOI
  10.1038/hr.2016.114
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-15K20616, KAKENHI-PROJECT-17K19673, KAKENHI-PROJECT-15H04806, KAKENHI-PROJECT-16K15199
[Journal Article] Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure.2017
- Author(s)
  Kamo T, Akazawa H, Suda W, Saga-Kamo A, Shimizu Y, Yagi H, Liu Q, Nomura S, Naito AT, Takeda N, Harada M, Toko H, Kumagai H, Ikeda Y, Takimoto E, Suzuki JI, Honda K, Morita H, Hattori M, Komuro I.
- Journal Title
  
  PLoS One.
  
  Volume: 12 Issue: 3 Pages: 0174099-0174099
- DOI
  10.1371/journal.pone.0174099
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26253049, KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-26461124, KAKENHI-PROJECT-15K19371, KAKENHI-PROJECT-15K09132, KAKENHI-PROJECT-17K08585, KAKENHI-PROJECT-17K19673, KAKENHI-PROJECT-17K15989, KAKENHI-PROJECT-15H04806, KAKENHI-PROJECT-16K15199, KAKENHI-PROJECT-17H01560
[Journal Article] Role of Hormone-sensitive Lipase in Leptin-Promoted Fat Loss and Glucose Lowering2017
- Author(s)
  Takanashi M, Taira Y, Okazaki S, Takase S, Kimura T, Li CC, Xu PF, Noda A, Sakata I, Kumagai H, Ikeda Y, Iizuka Y, Yahagi N, Shimano H, Osuga JI, Ishibashi S, Kadowaki T, Okazaki H
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 24 Issue: 11 Pages: 1105-1116
- DOI
  10.5551/jat.39552
- NAID
  130006191603
- ISSN
  1340-3478, 1880-3873
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08585, KAKENHI-PROJECT-17K19673, KAKENHI-PROJECT-15H02541, KAKENHI-PROJECT-15H03092, KAKENHI-PROJECT-15H04806, KAKENHI-PROJECT-16K13040, KAKENHI-PROJECT-16K15199
[Journal Article] A peptide vaccine targeting angiotensin II attenuates the cardiac dysfunction induced by myocardial infarction.2017
- Author(s)
  Watanabe R, Suzuki JI, Wakayama K, Maejima Y, Shimamura M, Koriyama H, Nakagami H, Kumagai H, Ikeda Y, Akazawa H, Morishita R, Komuro I, Isobe M.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 43920-43920
- DOI
  10.1038/srep43920
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04817, KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-17K08585, KAKENHI-PROJECT-17K19673, KAKENHI-PROJECT-15H04803, KAKENHI-PROJECT-15H04806, KAKENHI-PROJECT-16K15199
[Journal Article] Detrimental effects of specific Periodontopathic bacterial infection on tachyarrhythmia compared to Bradyarrhythmia.2017
- Author(s)
  Aoyama N, Suzuki J, Kobayashi N, Hanatani T, Ashigaki A, Yoshida A, Shiheido Y, Sato H, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Minabe M, Izumi Y, Isobe M.
- Journal Title
  
  BMC Cardiovasc Disord.
  
  Volume: 17 Pages: 267-267
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19673
[Journal Article] Specific periodontopathic bacterial infection affects hypertension in male cardiovascular disease patients2017
- Author(s)
  Aoyama Norio、Suzuki Jun-ichi、Kumagai Hidetoshi、Ikeda Yuichi、Akazawa Hiroshi、Komuro Issei、Minabe Masato、Izumi Yuichi、Isobe Mitsuaki
- Journal Title
  
  Heart Vessels.
  
  Volume: 33 Issue: 2 Pages: 198-204
- DOI
  10.1007/s00380-017-1042-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19673, KAKENHI-PROJECT-15H04806, KAKENHI-PROJECT-16K15199, KAKENHI-PROJECT-16H05824
[Journal Article] Generation and characterization of an antagonistic monoclonal antibody against an extracellular domain of mouse DP2 (CRTH2/GPR44) receptors for prostaglandin D22017
- Author(s)
  Nagata N, Iwanari H, Kumagai H, Kusano-Arai O, Ikeda Y, Aritake K, Hamakubo T, Urade Y
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 4 Pages: 0175452-0175452
- DOI
  10.1371/journal.pone.0175452
- NAID
  120007129138
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-17K08585, KAKENHI-PROJECT-17K19673, KAKENHI-PROJECT-15H04806, KAKENHI-PROJECT-16K15199, KAKENHI-PROJECT-16H01881
[Journal Article] Detrimental effects of specific Periodontopathic bacterial infection on tachyarrhythmia compared to Bradyarrhythmia2017
- Author(s)
  Aoyama Norio、Suzuki Jun-ichi、Kobayashi Naho、Hanatani Tomoya、Ashigaki Norihiko、Yoshida Asuka、Shiheido Yuka、Sato Hiroki、Kumagai Hidetoshi、Ikeda Yuichi、Akazawa Hiroshi、Komuro Issei、Minabe Masato、Izumi Yuichi、Isobe Mitsuaki
- Journal Title
  
  BMC Cardiovascular Disorders
  
  Volume: 17 Issue: 1 Pages: 267-267
- DOI
  10.1186/s12872-017-0703-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K17347, KAKENHI-PROJECT-15H04806, KAKENHI-PROJECT-16K15199, KAKENHI-PROJECT-16H05824
[Journal Article] Periodontitis deteriorates peripheral arterial disease in Japanese population via enhanced systemic inflammation2017
- Author(s)
  Aoyama N, Suzuki JI, Kobayashi N, Hanatani T, Ashigaki N, Yoshida A, Shiheido Y, Sato H, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Izumi Y, Isobe M
- Journal Title
  
  Heart Vessels
  
  Volume: 32 Issue: 11 Pages: 1314-1319
- DOI
  10.1007/s00380-017-1003-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08585, KAKENHI-PROJECT-17K19673, KAKENHI-PROJECT-17K17347, KAKENHI-PROJECT-15H04806, KAKENHI-PROJECT-16K15199, KAKENHI-PROJECT-16H05824
[Journal Article] Periodontitis and myocardial hypertrophy2017
- Author(s)
  Suzuki J, Sato H, Kaneko M, Yoshida A, Aoyama N, Akimoto S, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, IzumiY, Isobe M, Komuro I
- Journal Title
  
  Hypertens Res
  
  Volume: [Epub ahead of print] Issue: 4 Pages: 324-328
- DOI
  10.1038/hr.2016.146
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05824, KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-16K15422, KAKENHI-PROJECT-15K20616, KAKENHI-PROJECT-17K08585, KAKENHI-PROJECT-15H04806
[Journal Article] Toll-like receptor 4 signaling has a critical role in Porphyromonas gingivalis-accelerated neointimal formation after arterial injury in mice.2016
- Author(s)
  Kobayashi N, Suzuki JI, Aoyama N, Sato H, Akimoto S, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Izumi Y, Isobe M.
- Journal Title
  
  Hypertens Res
  
  Volume: 39 Issue: 10 Pages: 717-722
- DOI
  10.1038/hr.2016.58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04817, KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-16K15422, KAKENHI-PROJECT-16K15199, KAKENHI-PROJECT-15H04806
[Journal Article] Periodontitis May Deteriorate Sinus of Valsalva Dilatation in Marfan Syndrome Patients2016
- Author(s)
  Suzuki J, Imai Y, Aoki M, Fujita D, Takeda N, Aoyama N, Wakayama K, Ikeda Y, Kumagai H, Akazawa H, Izumi Y, Isobe M, Komuro I, Hirata Y
- Journal Title
  
  Int. Heart J.
  
  Volume: 57 Issue: 4 Pages: 456-460
- DOI
  10.1536/ihj.15-395
- NAID
  130006895913
- ISSN
  1349-2365, 1349-3299
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05824, KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-16K15422, KAKENHI-PROJECT-15K09132, KAKENHI-PROJECT-16K15199, KAKENHI-PROJECT-15H04806
[Journal Article] Current therapies and investigational drugs for peripheral arterial disease2016
- Author(s)
  Suzuki J, Shimamura M, Suda H, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, Isobe M, Komuro I, Morishita R
- Journal Title
  
  Hypertens Res
  
  Volume: 39 Issue: 4 Pages: 183-191
- DOI
  10.1038/hr.2015.134
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-15H04806, KAKENHI-PROJECT-16K15422, KAKENHI-PROJECT-16K15199
[Journal Article] Cacao polyphenols ameliorate autoimmune myocarditis in mice2016
- Author(s)
  Zempo H, Suzuki J, Watanabe R, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Isobe M
- Journal Title
  
  Hypertens Res
  
  Volume: 39 Issue: 4 Pages: 203-209
- DOI
  10.1038/hr.2015.136
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-15H04817, KAKENHI-PROJECT-16K15422, KAKENHI-PROJECT-16K15199
[Journal Article] Growth Differentiation Factor 15 (GDF15) as a Reliable Biomarker for Cardiovascular Risk Assessment2016
- Author(s)
  Ikeda Y1, Kumagai H, Motozawa Y, Suzuki J
- Journal Title
  
  Int. Heart J.
  
  Volume: 57 Issue: 1 Pages: 1-2
- DOI
  10.1536/ihj.15-324
- NAID
  130005120988
- ISSN
  1349-2365, 1349-3299
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-16K15422, KAKENHI-PROJECT-16K15199, KAKENHI-PROJECT-15H04806
[Journal Article] Angiotensin II receptor blocker irbesartan attenuates cardiac dysfunction induced by myocardial infarction in the presence of renal failure2016
- Author(s)
  Watanabe R, Suzuki J, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Isobe M
- Journal Title
  
  Hypertens Res
  
  Volume: 39 Issue: 4 Pages: 237-244
- DOI
  10.1038/hr.2015.141
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-15H04806, KAKENHI-PROJECT-25461122, KAKENHI-PROJECT-15H04817, KAKENHI-PROJECT-16K15422, KAKENHI-PROJECT-16K15199
[Journal Article] Corrigendum: Cacao polyphenols ameliorate autoimmune myocarditis in mice2016
- Author(s)
  Zempo H, Suzuki JI, Watanabe R, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Isobe M
- Journal Title
  
  Hypertens Res
  
  Volume: 39 Issue: 11 Pages: 828-828
- DOI
  10.1038/hr.2016.108
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460333
[Journal Article] Understanding vascular diseases: Lessons from premature aging syndromes2016
- Author(s)
  Ikeda Y, Kumagai H, Motozawa Y, Suzuki J, Akazawa H, Komuro I
- Journal Title
  
  Can J Cardiol
  
  Volume: 32 Issue: 5 Pages: 1-9
- DOI
  10.1016/j.cjca.2015.12.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-16K15422, KAKENHI-PROJECT-16K15199, KAKENHI-PROJECT-15H04806
[Journal Article] The Importance of Patient Education in the Chronic Phase of Kawasaki Disease2015
- Author(s)
  Motozawa Y, Uozumi H, Maemura S, Nakata R, Yamamoto K, Takizawa M, Kumagai H, Ikeda Y, Komuro I, Ikenouchi H
- Journal Title
  
  Int. Heart J.
  
  Volume: 56 Issue: 5 Pages: 551-554
- DOI
  10.1536/ihj.15-155
- NAID
  130005102122
- ISSN
  1349-2365, 1349-3299
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-15H04806
[Journal Article] Going Beyond Modulation of the Renin-Angiotensin System2015
- Author(s)
  Ikeda Y, Kumagai H, Motozawa Y, Suzuki J, Komuro I
- Journal Title
  
  Int. Heart J.
  
  Volume: 56 Issue: 6 Pages: 585-586
- DOI
  10.1536/ihj.15-295
- NAID
  130005113065
- ISSN
  1349-2365, 1349-3299
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-15H04806
[Journal Article] Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists2015
- Author(s)
  Nagahara T, Saitoh T, Kutsumura N, Irukayama-Tomobe Y, Ogawa Y, Kuroda D, Gouda H, Kumagai H, Fujii H, Yanagisawa M, Nagase H
- Journal Title
  
  J. Med. Chem
  
  Volume: 58 Issue: 20 Pages: 7931-7937
- DOI
  10.1021/acs.jmedchem.5b00988
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-15K16557, KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-26220207
[Journal Article] Monitoring beta-arrestin recruitment via beta-lactamase enzyme fragment complementation: purification of peptide E as a low-affinity ligand for mammalian bombesin receptors2015
- Author(s)
  Ikeda Y*, Kumagai H*, Okazaki H, Fujishiro M, Motozawa Y, Nomura S, Takeda N, Toko H, Takimoto E, Akazawa H, Morita H, Suzuki J, Yamazaki T, Komuro I, Yanagisawa M (co-first author)
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 6 Pages: e0127445-e0127445
- DOI
  10.1371/journal.pone.0127445
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-26461124, KAKENHI-PROJECT-15K19371, KAKENHI-PROJECT-26253049, KAKENHI-PROJECT-15H04806, KAKENHI-PROJECT-15K15047, KAKENHI-PROJECT-26670395
[Journal Article] A Potential Strategy for the Treatment of Acute Heart Failure2015
- Author(s)
  Ikeda Y*, Kumagai H*, Motozawa Y*, Suzuki J, Komuro I (co-first author)
- Journal Title
  
  Int. Heart J.
  
  Volume: 56 Issue: 5 Pages: 485-488
- DOI
  10.1536/ihj.15-256
- NAID
  130005102121
- ISSN
  1349-2365, 1349-3299
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-15H04806
[Journal Article] Quantitative measurement of GPCR endocytosis via pulse-chase covalent labeling2015
- Author(s)
  Kumagai H, Ikeda Y, Motozawa Y, Fujishiro M, Okamura T, Fujio K, Okazaki H, Nomura S, Takeda N, Harada M, Toko H, Takimoto E, Akazawa H, Morita H, Suzuki J, Yamazaki T, Yamamoto K, Komuro I, Yanagisawa M
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 5 Pages: e0129394-e0129394
- DOI
  10.1371/journal.pone.0129394
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-26461124, KAKENHI-PROJECT-15K19371, KAKENHI-PROJECT-26253049, KAKENHI-PROJECT-15H04806, KAKENHI-PROJECT-15K15047, KAKENHI-PROJECT-26670395
[Journal Article] A food-derived flavonoid luteolin protects against angiotensin II-induced cardiac remodeling2015
- Author(s)
  Nakayama A, Morita H, Nakao T, Yamaguchi T, Sumida T, Ikeda Y, Kumagai H, Motozawa Y, Takahashi T, Imaizumi A, Hashimoto T, Nagai R, Komuro I
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 9 Pages: e0137106-e0137106
- DOI
  10.1371/journal.pone.0137106
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460333, KAKENHI-PROJECT-15H04806, KAKENHI-PROJECT-15K15047

1. IKEDA Yuichi (10744419)

# of Collaborated Projects: 7 results

# of Collaborated Products: 7 results
2. Morita Hiroyuki (60323573)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. ONO Teruo (00000927)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. SAKAKIBARA Jun (90242403)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. FUJII Hiroshi (90165340)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. Fujishiro Mitsuhiro (70396745)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
7. 山下裕玄 (50599397)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. 浅岡良成 (90431858)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. 星野力 (30165542)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 東口治弘 (40436358)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
11. YANAGISAWA Masashi (20202369)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. Harada Mutsuo (90431642)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. URADE Yoshihiro (10201360)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 篠原正和 (80437483)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. SCHROEPFER George

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SHECHTER Ishaiahu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. PRESTWICH Glenn

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. STEIN J.P.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. STEIN Joseph

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. LAW J.A

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. SCHROPFER G.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 磯部光章

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
23. 内藤篤彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 野村征太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 小室一成

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
26. 前嶋康浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 始平堂由佳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 和泉雄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 鈴木淳一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 青山典生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kumagai Hidetoshi 熊谷 英敏

KUMAGAI Hidetoshi 熊谷 英敏

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Screening for selective NFATc4 inhibitors to develop a drug of heart failurePrincipal Investigator

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Screening for peptide ligands that activate beta-arrestin biasd cell signaling of orphan GPCRsPrincipal Investigator

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[Journal Article] Novel computer-assisted diagnosis system for endoscopic disease activity in patients with ulcerative colitis2019

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[Journal Article] Corrigendum to “Enhancing endogenous adenosine A2A receptor signaling induces slow-wave sleep without affecting body temperature and cardiovascular function” [Neuropharmacology 144 (2019) 122?132]2019

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[Journal Article] Critical Role of SREBP-1c Large-VLDL Pathway in Environment-Induced Hypertriglyceridemia of Apo AV Deficiency2019

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[Journal Article] Diagnostic outcomes of esophageal cancer by artificial intelligence using convolutional neural networks2019

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Kumagai Hidetoshi 熊谷英敏

KUMAGAI Hidetoshi 熊谷英敏