ITO Takashi 伊藤隆史

Researcher Number	20381171
Other IDs
External Links
Affiliation (Current)	2025: 熊本大学, 大学院生命科学研究部(保) , 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 熊本大学, 大学院生命科学研究部(保), 教授 2020 – 2023: 鹿児島大学, 医歯学総合研究科, 特任准教授 2015 – 2019: 鹿児島大学, 医歯学総合研究科, 講師 2017: 鹿児島大学, 医学部・歯学部附属病院, その他 2013 – 2016: 鹿児島大学, 医歯(薬)学総合研究科, 講師 … More 2015: 鹿児島大学, 医歯学域医学系, 講師 2014 – 2015: 鹿児島大学, 大学院医歯学総合研究科, 講師 2013 – 2014: 鹿児島大学, 大学院医歯学総合研究科, 特任講師 2012 – 2014: 鹿児島大学, 医歯(薬)学総合研究科, 特任講師 2013: 鹿児島大学, 大学院医歯(薬)学総合研究科, 特任講師 2011 – 2013: 鹿児島大学, 大学院・医歯学総合研究科, 特任講師 2011 – 2012: 鹿児島大学, 医歯学総合研究科, 特任講師 2011: 鹿児島大学, 大学院・医歯学総合研究科, 教授 2011: 鹿児島大学, 大学院・医歯総合研究科, 特任講師 2005 – 2007: 鹿児島大学, 医学部・歯学部附属病院, 医員 Less
Review Section/Research Field	Principal Investigator Emergency medicine / Basic Section 55060:Emergency medicine-related Except Principal Investigator Emergency medicine / Basic Section 55060:Emergency medicine-related / Hematology / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Laboratory medicine / Basic Section 54010:Hematology and medical oncology-related / Basic Section 42020:Veterinary medical science-related / Anesthesiology / Neurology
Keywords	Principal Investigator 敗血症 / DAMPs / トロンボモジュリン / ヒストン / 抗体 / 集中治療 / 細胞外ヒストン / 血栓症 / 血栓 / DAMPｓ … More / 集中治療医学 / HMGB1 / DIC / ショック / 炎症 / 播種性血管内凝固症候群 / 腸内細菌叢 / メタボローム / 腸内細菌 / 組織損傷 / メディエーター / 診断 / 治療 / 播種性血管内凝固（DIC） / アイソフォーム / 核内タンパク質 / ヘパリン起因性血小板減少症（HIT） / ポイントオブケア / HIT / ヘパリン起因性血小板減少症 / ヘパリン / 抗凝固薬 / コンドロイチン硫酸 / 血栓性微小血管障害症 / von Willebrand因子 / 血管内皮細胞 / 病理学 / 免疫学 / バソプレシン / 敗血症性ショック / 血栓形成 / 播種性血管内凝固症候群(DIC) / 虚血再還流 / 凝固 … More Except Principal Investigator DAMPs / 敗血症 / ヒストン / HMGB1 / DIC / トロンボモジュリン / PAMPs / PAMPｓ / DAMPｓ / Histones / アラーミン / ヌクレオフォスミン / トロンビン / テトラヒドロビオプテリン / Thrombomodulin / 細胞外ヒストン / exosome / Exosome / エクソソーム / 一酸化窒素 / 血管内皮細胞 / microRNA / 敗血症性ショック / protein C / RAMPs / DAMP / 救急医学 / プロテインC / 血栓 / VEGF-A / B細胞 / リンパ節 / 免疫 / thrombomodulin / 炎症 / 感染症 / DIC診断基準 / CyTOF / 播種性血管内凝固症候群 / ワクチン / 予防 / トラネキサム酸 / アンチトロンビン / ヘパリン / ヤマカガシ毒素 / 線溶 / 蛇毒咬傷 / 血清療法 / 抗毒素 / ヤマカガシ咬傷 / TTAS / 敗血症モデル / Nets / 播種性血管内凝固（DIC） / ユビキチン / PROTAC / フェノールポリマー / シノビオリン / ユビキチンリガーゼ / ペプチド / αヘリックス / 治療ターゲット / 炎症性サイトカイン / 抑制ペプチド / 敗血症治療 / 芳香族アミノ酸 / アミノ酸 / アミノ酸代謝 / 敗血症関連脳症 / 順行性脳血流 / 脳酸素飽和度 / 心肺停止 / 胸骨圧迫法 / 空間分解分光法 / 時間分解分光法 / 逆行性脳血流 / 脳内酸素飽和度 / パルス波形 / NIRO装置 / 近赤外線分光法 / 自己心拍再開 / 胸骨圧迫 / 心肺蘇生法 / shock / skimming / sludging / Thrombomodulin(TM) / Blood sludging / Blood skimming / 組織因子 / 第Ⅶ因子 / 血栓塞栓症 / 癌 / blood sludging / blood skimming / Trousseau syndrome / Thrombosis / Cancer Procoagulant / 血球成分 / 血漿成分 / 出血 / 血栓・塞栓 / T-TAS / Sludging / Skimming / 血流動態異常 / 一酸化窒素合成酵素 / プテリジン / アスコルビン酸 / thrombin / EPCR / Protein C / TM / Thrombin / 修復 / 止血 / 組織損傷 / 生体損傷 / RAMPｓ / 虚血再灌流 / 虚血再灌流傷害 / 麻酔 / 虚血再灌流障害 / alarmins / Organ failure / ARDS / メラノーマ細胞株A375 / Alix / Heat shock protein / 糖鎖構造 / エクソゾーム / miRNA / 単球 / 単核球 / radical / sprvqis / ock / thromb in / hrombomodulin / 免疫学 / 循環器・高血圧 / 救命 / 播種性血管内凝固症候群(DIC) / ラディカル / ショック / トロンボモデュリン / 受容体 / 外科系臨床医学 / 細胞・組織 / オートファジー / インフラマソーム / エピジェネティック / HMGB1酸化還元型 / ヒト化モノクローナル抗体 / レドックス状態 / NETs / histones / 多臓器不全 / Shock / Alarmin / IL-18 / IL-1β / Inflammasome / Ａｄｅｎｏｓｉｎｅ / ＡＴＰ / inflammation / platelet / PAMP / ATP / ファゴサイトーシス / 免疫活性化 / 老化 / 活性酸素 / 血管新生 / 肝 / 脾 / 鉄 / hepcidin / 血管内皮細胞増殖因子 / 病態検査学 / eryptosis / 貧血 / 鉄代謝 / 血球貪食 / 血管透過性 / 赤血球 / 脾臓 / des-HMGB1 / 止血学 / 発現制御 / 糖尿病 / 蛋白質 / シグナル伝達 / TLR-4 / TLR-2 / NF-ｋB / PAR-1 / inflammasome / mouse / high endothelial venule / lymph node / nervus system / immune system / POEMS syndrome / angiogenesis / HEV / iron / spleen / lymph / immune / B cell / LPS tolerance / 高内皮小静脈 / VEGF / 神経 / 補体 / プラットフォーム分子 / 集中治療医学 / 病理学 / 微生物 / 細菌 Less

DAMPsサブタイプ特異的抗体を駆使した敗血症の階層化と分子標的治療技術の構築Principal Investigator
- Principal Investigator
  
  伊藤隆史
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Kumamoto University
DAMPsワクチンの開発と積極的な予防法の確立とその応用
- Principal Investigator
  
  川原幸一
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Osaka Institute of Technology
トロンボモジュリン欠損患者 iPS細胞から成熟分化細胞の確立と機能解析及び患者還元
- Principal Investigator
  
  本田剛一
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Fukushima Medical University
ヒストンが関連する免疫血栓からDICへの進展機序解明に基づく新たなDIC診断基準の策定
- Principal Investigator
  
  和田剛志
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Hokkaido University
播種性血管内凝固の早期診断の確立：NETsに関連した臨床マーカーはどれか
- Principal Investigator
  
  岩永朋子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Tokyo University of Agriculture and Technology
Alternative treatment of Yamakagashi bites
- Principal Investigator
  
  一二三亨
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  St. Luke's International University
Reconstruction of metabolism in sepsis by targeting gut microbiotaPrincipal Investigator
- Principal Investigator
  
  ITO Takashi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Kumamoto University
Development of peptides that regulate DAMPs and their application deployment.
- Principal Investigator
  
  Kawahara Ko-ichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Osaka Institute of Technology
Challenging the intracellular degradation of histones through the fusion of new technologies.
- Principal Investigator
  
  Kawahara Ko-ichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Osaka Institute of Technology
Development of physiological monitoring method by NIRS to evaluate appropriate chest compression at cardiac arrest
- Principal Investigator
  
  Kakihana Yasuyuki
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Kagoshima University
Tetrahydrobiopterin in sepsis associated encephalopathy and its consideration as a therapeutic target.
- Principal Investigator
  
  Kamikokuryo Chinatsu
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Kagoshima University
Study of the dynamics of tetrahydrobiopterin in sepsis and the potentiality of BH4 as therapeutic target.
- Principal Investigator
  
  Yasuda Tomotsugu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Kagoshima University
Cellular and molecular mechanism of blood sludging/skimming. Causative role of cancer exosomes and their pathophysiological view points
- Principal Investigator
  
  MARUYAMA Ikuro
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Kagoshima University
A novel therapeutic strategy targeting HMGB1 isoforms in sepsisPrincipal Investigator
- Principal Investigator
  
  ITO Takashi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Kagoshima University
Research on the interaction of histones in pathophysiology of sepsis and its application
- Principal Investigator
  
  Kawahara Ko-ichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Osaka Institute of Technology
Novel therapeutic proposal for DIC/Shock: from Damage-Sensing/-Control to Damage Resolution
- Principal Investigator
  
  MARUYAMA Ikuro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
Pathophysiological significance of two types of DAMPs, naked- and exosomal type.
- Principal Investigator
  
  MARUYAMA Ikuro
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
Novel simulation technique for diagnosing heparin-induced thrombocytopenia (HIT)Principal Investigator
- Principal Investigator
  
  Ito Takashi
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
The mechamism of novel alarmin
- Principal Investigator
  
  Kawahara Ko-ichi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Osaka Institute of Technology
Construction of the system of
- Principal Investigator
  
  Yamakuchi Munekazu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Kagoshima University
Therapeutic strategy targeting extracellular histones in sepsis-associated DICPrincipal Investigator
- Principal Investigator
  
  ITO Takashi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
Proposal of novel concept, Exosome cargo as a novel DAMPs delivery system
- Principal Investigator
  
  MARUYAMA Ikuro
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
Multi-layered and topological regulatory system of PAMPs and DAMPs. Its relevance in various pathophysiology.
- Principal Investigator
  
  MARUYAMA Ikuro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
The analysis of inflammasome activation in extracellular histones
- Principal Investigator
  
  Kawahara Ko-ihi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Emergency medicine
- Research Institution
  Osaka Institute of Technology
Extracellular histones stimulate endothelial cells to release unusually-large von Willebrand factor multimer: mechanistic insight into the pathogenesis of lethal coagulopathyPrincipal Investigator
- Principal Investigator
  
  ITO Takashi
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
PAMPs, DAMPs regulation by thrombomodulin(TM). Probable role of epithelial TM
- Principal Investigator
  
  MARUYAMA Ikuro
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
The receptor and inhibitor of Nucleophosmin
- Principal Investigator
  
  Kawahara Ko-ichi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Osaka Institute of Technology
evaluation of organ protective effects of anesthetic agents using extra-cellular histone modification in liver ischemia-reperfusion injury
- Principal Investigator
  
  Nakahara Mayumi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Anesthesiology
- Research Institution
  Kagoshima University
Extracellular histones as a myocardial depressant factorPrincipal Investigator
- Principal Investigator
  
  ITO Takashi
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
Localization and regulation in reactive sites of DAMPs/PAMPs. Role of ATP from the activated plateles
- Principal Investigator
  
  MARUYAMA Ikuro
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
HMGB1-induced vaspressin deficiency contributes to septic shockPrincipal Investigator
- Principal Investigator
  
  ITO Takashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
Contribution of vascular permeability for aging erythrocyte selection in spleen
- Principal Investigator
  
  HASHIGUCHI Teruto
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Kagoshima University
A role of extracellular histones as mediators of death in sepsisPrincipal Investigator
- Principal Investigator
  
  ITO Takashi
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
Comprehensive regulatory system of PAMPs/DAMPs by TM-PC/EPCR system
- Principal Investigator
  
  MARUYAMA Ikuro
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
Nucleophosmin: immunoactivity as a novel alarmin
- Principal Investigator
  
  KAWAHARA Ko-ichi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Osaka Institute of Technology
Cellular mechanism in thrombin mediated HMGB1 release. Effect of cluster formation of HMGB1 on the cell-surface receptors.
- Principal Investigator
  
  MARUYAMA Ikuro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
Establishment and dynamism of des-HMGB1, degraded HMGB1 by thrombin-thrombomodulin
- Principal Investigator
  
  MARUYAMA Ikuro
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Kagoshima University
DAMPs : novel molecular targets for DIC therapyPrincipal Investigator
- Principal Investigator
  
  ITO Takashi
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
Immunomodulatory effects ofB cell derivedVEGF-A in mice
- Principal Investigator
  
  HASHIGUCHI Teruto
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Kagoshima University
Development of a novel anti-inflammation effect in a Thrombomodulin as a platform type molecule
- Principal Investigator
  
  KAWAHARA Ko-ichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Emergency medicine
- Research Institution
  Osaka Institute of Technology
  Kagoshima University
死のメディエーター:HMGB1が臓器不全を引き起こす機序Principal Investigator
- Principal Investigator
  
  伊藤隆史
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
凝固外因系と自然免疫系のクロストークとシナージズム
- Principal Investigator
  
  MARUYAMA Ikuro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Kagoshima University
Thrombomodulin : As a regulator of multiple mediators
- Principal Investigator
  
  MARUYAMA Ikuro
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Kagoshima University

[Book] 集中治療医学2023
- Author(s)
  編集：一般社団法人日本集中治療医学会　分担執筆：伊藤隆史
- Total Pages
  424
- Publisher
  Gakken
- ISBN
  4055100248
- Data Source
  KAKENHI-PROJECT-21H03033
[Book] New Strategy! 超微形態生理学　ICU輸液がみえるグリコカリックス×アトラス2020
- Author(s)
  伊藤　隆史
- Total Pages
  268
- Publisher
  メジカルビュー社
- ISBN
  9784758317818
- Data Source
  KAKENHI-PROJECT-18H02904
[Book] ファーマナビゲーター　 DIC編　改訂版2019
- Author(s)
  伊藤隆史
- Total Pages
  435
- Publisher
  メディカルレビュー社
- ISBN
  9784779222337
- Data Source
  KAKENHI-PROJECT-18H02904
[Book] 麻酔・手術後の患者管理2016
- Author(s)
  伊藤隆史・垣花泰之
- Total Pages
  360
- Publisher
  克誠堂出版
- Data Source
  KAKENHI-PROJECT-15H05684
[Book] 麻酔・手術後の患者管理2016
- Author(s)
  伊藤隆史・垣花泰之
- Total Pages
  360
- Publisher
  克誠堂出版
- Data Source
  KAKENHI-PROJECT-16K15764
[Book] 新・血栓止血血管学「血管と血小板」2015
- Author(s)
  伊藤隆史
- Total Pages
  251
- Publisher
  金芳堂
- Data Source
  KAKENHI-PROJECT-15H05684
[Book] 新・血栓止血血管学「凝固と炎症」2015
- Author(s)
  伊藤隆史
- Total Pages
  189
- Publisher
  金芳堂
- Data Source
  KAKENHI-PROJECT-15H05684
[Book] Recent advances in Thrombosis and Hemostasis 20082008
- Author(s)
  Takashi Ito, et. al.
- Total Pages
  650
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-18791341
[Journal Article] Observation of blood motion in the internal jugular vein by contact and contactless photoplethysmography during physiological testing: case studies2024
- Author(s)
  Saiko G, Burton T, Kakihana Y, Hatanaka K, Takahito O, Douplik A
- Journal Title
  
  Biomed Opt Express
  
  Volume: 25 Issue: 4 Pages: 2578-2589
- DOI
  10.1364/boe.516609
- Data Source
  KAKENHI-PROJECT-19K09400
[Journal Article] Effects of combination therapy of antithrombin and thrombomodulin for sepsis-associated disseminated intravascular coagulation: a systematic review and meta-analysis2024
- Author(s)
  Totoki Takaaki、Makino Yuto、Yamakawa Kazuma、Koami Hiroyuki、Wada Takeshi、Ito Takashi、Iba Toshiaki
- Journal Title
  
  Thrombosis Journal
  
  Volume: 22 Issue: 1 Pages: 10-10
- DOI
  10.1186/s12959-023-00579-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16628, KAKENHI-PROJECT-21H03033
[Journal Article] Anticoagulation therapy for microvascular dysfunction2023
- Author(s)
  TOTOKI Takaaki、ITO Takashi
- Journal Title
  
  Japanese Journal of Thrombosis and Hemostasis
  
  Volume: 34 Issue: 6 Pages: 671-678
- DOI
  10.2491/jjsth.34.671
- ISSN
  0915-7441, 1880-8808
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16628, KAKENHI-PROJECT-21H03033
[Journal Article] Hypersensitivity of myelinated A-fibers via toll-like receptor 5 promotes mechanical allodynia in tenascin-X-deficient mice associated with Ehlers?Danlos syndrome2023
- Author(s)
  Kamada Hiroki、Emura Kousuke、Yamamoto Rikuto、Kawahara Koichi、Uto Sadahito、Minami Toshiaki、Ito Seiji、Matsumoto Ken-ichi、Okuda-Ashitaka Emiko
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 1-10
- DOI
  10.1038/s41598-023-45638-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19544
[Journal Article] Damage-associated molecular patterns and fibrinolysis perturbation are associated with lethal outcomes in traumatic injury.2023
- Author(s)
  Shimono K, Ito T, Kamikokuryo C, Niiyama S, Yamada S, Onishi H, Yoshihara H, Maruyama I, Kakihana Y.
- Journal Title
  
  Thromb J
  
  Volume: 21(1) Issue: 1 Pages: 91-91
- DOI
  10.1186/s12959-023-00536-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09291, KAKENHI-PROJECT-21H03033
[Journal Article] Attempt for a Recombinant Thrombomodulin Alpha Treatment in a Rat Disseminated Intravascular Coagulation Model Using Yamakagashi (Rhabdophis tigrinus) Venom2022
- Author(s)
  Yamamoto Akihiko、Ito Takashi、Hifumi Toru
- Journal Title
  
  Toxins
  
  Volume: 14 Issue: 5 Pages: 322-322
- DOI
  10.3390/toxins14050322
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03033, KAKENHI-PROJECT-18K08890
[Journal Article] Early ascorbic acid administration prevents vascular endothelial cell damage in septic mice2022
- Author(s)
  Yutaro Madokoro, Chinatsu Kamikokuryo, Shuhei Niiyama, Takashi Ito, Satoshi Hara, Hiroshi Ichinose, Yasuyuki Kakihana
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: - Pages: 929448-929448
- DOI
  10.3389/fphar.2022.929448
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09291, KAKENHI-PROJECT-21H03033, KAKENHI-PROJECT-19K09438
[Journal Article] Attempt to Develop Rat Disseminated Intravascular Coagulation Model Using Yamakagashi (Rhabdophis tigrinus) Venom Injection2021
- Author(s)
  Yamamoto Akihiko、Ito Takashi、Hifumi Toru
- Journal Title
  
  Toxins
  
  Volume: 13 Issue: 2 Pages: 160-160
- DOI
  10.3390/toxins13020160
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08890, KAKENHI-PROJECT-18H02904
[Journal Article] Circulating Syndecan-1 as a Predictor of Persistent Thrombocytopenia and Lethal Outcome: A Population Study of Patients With Suspected Sepsis Requiring Intensive Care2021
- Author(s)
  Hatanaka Kosaku、Ito Takashi、Madokoro Yutaro、Kamikokuryo Chinatsu、Niiyama Shuhei、Yamada Shingo、Maruyama Ikuro、Kakihana Yasuyuki
- Journal Title
  
  Frontiers in Cardiovascular Medicine
  
  Volume: 8 Pages: 730553-730553
- DOI
  10.3389/fcvm.2021.730553
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03033, KAKENHI-PROJECT-20K09291
[Journal Article] 1,5-Anhydro-D-fructose Protects against Rotenone-Induced Neuronal Damage In Vitro through Mitochondrial Biogenesis2021
- Author(s)
  Kasamo Yuki、Kikuchi Kiyoshi、Yamakuchi Munekazu、Otsuka Shotaro、Takada Seiya、Kambe Yuki、Ito Takashi、Kawahara Ko-ichi、Arita Kazunori、Yoshimoto Koji、Maruyama Ikuro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 18 Pages: 9941-9941
- DOI
  10.3390/ijms22189941
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K19312, KAKENHI-PROJECT-21H03037, KAKENHI-PROJECT-20K11640, KAKENHI-PROJECT-21K19454, KAKENHI-PROJECT-21K19544
[Journal Article] Endotheliopathy in septic conditions: mechanistic insight into intravascular coagulation2021
- Author(s)
  Ito Takashi、Kakuuchi Midori、Maruyama Ikuro
- Journal Title
  
  Critical Care
  
  Volume: 25 Issue: 1 Pages: 95-95
- DOI
  10.1186/s13054-021-03524-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02904
[Journal Article] Potential roles of 1,5-anhydro-d-fructose in modulating gut microbiome in mice2021
- Author(s)
  Ito Takashi、Totoki Takaaki、Takada Seiya、Otsuka Shotaro、Maruyama Ikuro
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 19648-19648
- DOI
  10.1038/s41598-021-99052-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03033
[Journal Article] Recombinant thrombomodulin alleviates oxidative stress without compromising host resistance to infection in rats infected with methicillin-resistant Staphylococcus aureus2020
- Author(s)
  Ito Takashi、Shrestha Binita、Kakihana Yasuyuki、Maruyama Ikuro
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 17413-17413
- DOI
  10.1038/s41598-020-74529-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02904
[Journal Article] TLR4/MD-2 is a receptor for extracellular nucleophosmin 12020
- Author(s)
  Nakatomi Kota、Ueno Hikari、Ishikawa Yuto、Salim Ronny、Mori Yuki、Kanemoto Issey、Tancharoen Salunya、Kikuchi Kiyoshi、Miura Naoki、Omori Taketo、Okuda?ashitaka Emiko、Matsumura Kiyoshi、Imaizumi Hitoshi、Motomiya Yoshihiro、Maruyama Ikuro、Kawahara Ko-Ichi
- Journal Title
  
  Biomedical Reports
  
  Volume: 14 Issue: 2 Pages: 1-6
- DOI
  10.3892/br.2020.1397
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K11640, KAKENHI-PROJECT-18H02906
[Journal Article] Leukocyte-derived extracellular DNA contributes to abnormal pressure elevation in the extracorporeal circulation circuit2020
- Author(s)
  Yashima Nozomi、Ito Takashi、Kajiyama Kenji、Maeda Hiroyuki、Kakihana Yasuyuki、Maruyama Ikuro
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1
- DOI
  10.1038/s41598-019-57173-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04363, KAKENHI-PROJECT-18K19587
[Journal Article] Effects of thrombomodulin alfa on hemostatic parameters in disseminated intravascular coagulation: Post hoc analysis of a phase 3 randomized controlled trial2020
- Author(s)
  Ito Takashi、Maruyama Ikuro、Shimazaki Shuji、Yamamoto Yasuhiro、Aikawa Naoki、Hirayama Akio、Honda Goichi、Saito Hidehiko
- Journal Title
  
  Research and Practice in Thrombosis and Haemostasis
  
  Volume: 4 Issue: 7 Pages: 1141-1149
- DOI
  10.1002/rth2.12419
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02904
[Journal Article] Circulating histone H3 levels in septic patients are associated with coagulopathy, multiple organ failure, and death: a single-center observational study2019
- Author(s)
  Yokoyama Yayoi、Ito Takashi、Yasuda Tomotsugu、Furubeppu Hiroaki、Kamikokuryo Chinatsu、Yamada Shingo、Maruyama Ikuro、Kakihana Yasuyuki
- Journal Title
  
  Thrombosis Journal
  
  Volume: 17 Issue: 1 Pages: 1-1
- DOI
  10.1186/s12959-018-0190-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02904, KAKENHI-PROJECT-17H04363, KAKENHI-PROJECT-16K10746, KAKENHI-PROJECT-18K19587
[Journal Article] Fulminant myocarditis associated with severe fever with thrombocytopenia syndrome: a case report.2019
- Author(s)
  Miyamoto S, Ito T, Terada S, Eguchi T, Furubeppu H, Kawamura H, Yasuda T, Kakihana Y.
- Journal Title
  
  BMC Infect Dis
  
  Volume: 19 Issue: 1 Pages: 266-266
- DOI
  10.1186/s12879-019-3904-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09236, KAKENHI-PROJECT-18H02904
[Journal Article] Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patients with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation2019
- Author(s)
  Namino F, Yamakuchi M, Iriki Y, Okui H, Ichiki H, Maenosono R, Oketani N, Masamoto I, Miyata M, Horiuchi M, Hashiguchi T, Ohishi M, Maruyama I
- Journal Title
  
  Clin Appl Thromb Hemost
  
  Volume: 25 Pages: 107602961985157-107602961985157
- DOI
  10.1177/1076029619851570
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09593, KAKENHI-PROJECT-19K17608, KAKENHI-PROJECT-17H04363, KAKENHI-PROJECT-16K10746, KAKENHI-PROJECT-18K19587
[Journal Article] Thrombomodulin in disseminated intravascular coagulation and other critical conditions-a multi-faceted anticoagulant protein with therapeutic potential2019
- Author(s)
  Ito T, Thachil J, Asakura H, Levy JH, Iba T.
- Journal Title
  
  Crit Care
  
  Volume: 23 Issue: 1 Pages: 280-280
- DOI
  10.1186/s13054-019-2552-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09430, KAKENHI-PROJECT-18H02904
[Journal Article] Loss of Endogenous HMGB2 Promotes Cardiac Dysfunction and Pressure Overload-Induced Heart Failure in Mice2019
- Author(s)
  Sato M, Miyata K, Tian Z, Kadomatsu T, Ujihara Y, Morinaga J, Horiguchi H, Endo M, Zhao J, Zhu S, Sugizaki T, Igata K, Muramatsu M, Minami T, Ito T, Bianchi ME, Mohri S, Araki K, Node K, Oike Y
- Journal Title
  
  Circ J
  
  Volume: 83 Issue: 2 Pages: 368-378
- DOI
  10.1253/circj.CJ-18-0925
- NAID
  130007557092
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2019-01-25
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08663, KAKENHI-PROJECT-18K15246, KAKENHI-PUBLICLY-17H05652, KAKENHI-PROJECT-18H02809, KAKENHI-PROJECT-18H02904, KAKENHI-PROJECT-17H04740, KAKENHI-PROJECT-16K07093, KAKENHI-PROJECT-16K09504, KAKENHI-PROJECT-17K15622, KAKENHI-PROJECT-18KT0026, KAKENHI-PROJECT-19K17607, KAKENHI-PUBLICLY-19H04972, KAKENHI-PROJECT-17H03580, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18K19519
[Journal Article] Recombinant Thrombomodulin Suppresses Histone-Induced Neutrophil Extracellular Trap Formation2019
- Author(s)
  Shrestha Binita、Ito Takashi、Kakuuchi Midori、Totoki Takaaki、Nagasato Tomoka、Yamamoto Mika、Maruyama Ikuro
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 10 Pages: 2535-2535
- DOI
  10.3389/fimmu.2019.02535
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04363, KAKENHI-PROJECT-18H02904, KAKENHI-PROJECT-16K10746, KAKENHI-PROJECT-18K19587
[Journal Article] Effects of glycemic control and hypoglycemia on Thrombus formation assessed using automated microchip flow chamber system: an exploratory observational study.2019
- Author(s)
  Yamamoto K, Ito T, Nagasato T, Shinnakasu A, Kurano M, Arimura A, Arimura H, Hashiguchi H, Deguchi T, Maruyama I, Nishio Y.
- Journal Title
  
  Thromb J.
  
  Volume: 17 Issue: 1
- DOI
  10.1186/s12959-019-0206-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10746, KAKENHI-PROJECT-18K19587
[Journal Article] Serum histone H3 levels and platelet counts are potential markers for coagulopathy with high risk of death in septic patients: a single-center observational study2019
- Author(s)
  Ito Takashi、Totoki Takaaki、Yokoyama Yayoi、Yasuda Tomotsugu、Furubeppu Hiroaki、Yamada Shingo、Maruyama Ikuro、Kakihana Yasuyuki
- Journal Title
  
  Journal of Intensive Care
  
  Volume: 7 Issue: 1 Pages: 63-63
- DOI
  10.1186/s40560-019-0420-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04363, KAKENHI-PROJECT-18H02904, KAKENHI-PROJECT-16K10746, KAKENHI-PROJECT-18K19587
[Journal Article] Circulating activated protein C levels are not increased in septic patients treated with recombinant human soluble thrombomodulin2018
- Author(s)
  Arishima Takuro、Ito Takashi、Yasuda Tomotsugu、Yashima Nozomi、Furubeppu Hiroaki、Kamikokuryo Chinatsu、Futatsuki Takahiro、Madokoro Yutaro、Miyamoto Shotaro、Eguchi Tomohiro、Haraura Hiroyuki、Maruyama Ikuro、Kakihana Yasuyuki
- Journal Title
  
  Thrombosis Journal
  
  Volume: 16 Issue: 1 Pages: 24-24
- DOI
  10.1186/s12959-018-0178-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19587, KAKENHI-PROJECT-17H04363
[Journal Article] Oxygen management in mechanically ventilated patients: A multicenter prospective observational study2018
- Author(s)
  Egi M, Kataoka J, Ito T, et al.
- Journal Title
  
  J Crit Care.
  
  Volume: 21 Pages: 1-5
- DOI
  10.1016/j.jcrc.2018.03.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H05684, KAKENHI-PROJECT-18K16439
[Journal Article] Circulating histone H3 levels are increased in septic mice in a neutrophil-dependent manner: preclinical evaluation of a novel sandwich ELISA for histone H32018
- Author(s)
  Ito Takashi、Nakahara Mayumi、Masuda Yoshiki、Ono Sachie、Yamada Shingo、Ishikura Hiroyasu、Imaizumi Hitoshi、Kamikokuryo Chinatsu、Kakihana Yasuyuki、Maruyama Ikuro
- Journal Title
  
  Journal of Intensive Care
  
  Volume: 6 Issue: 1 Pages: 79-79
- DOI
  10.1186/s40560-018-0348-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19587, KAKENHI-PROJECT-17H04363, KAKENHI-PROJECT-18H02904
[Journal Article] Uric acid enhances alteplase-mediated thrombolysis as an antioxidant.2018
- Author(s)
  Kikuchi K, Setoyama K, Tanaka E, Otsuka S, Terashi T,Nakanishi K, Takada S, Sakakima H, Ampawong S, Kawahara KI, Nagasato T, Hosokawa K, Harada Y, YamamotoM, Kamikokuryo C, Kiyama R, Morioka M, Ito T, Maruyama I, Tancharoen S.
- Journal Title
  
  Sci Rep.
  
  Volume: 8(1) Issue: 1 Pages: 15844-15844
- DOI
  10.1038/s41598-018-34220-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05845, KAKENHI-PROJECT-18H02906, KAKENHI-PROJECT-16K10746
[Journal Article] Edaravone, a Synthetic Free Radical Scavenger, Enhances Alteplase-Mediated Thrombolysis.2017
- Author(s)
  Kikuchi K, Setoyama K, Kawahara KI, Nagasato T, Terashi T, Ueda K, Nakanishi K, Otsuka S, Miura N, Sameshima H, Hosokawa K,Harada Y, Shrestha B, Yamamoto M, Morimoto-Yamashita Y, Kikuchi H, Kiyama R, Kamikokuryo C, Tancharoen S, Sakakima H, Morioka M, Tanaka E, Ito T, Maruyama I.
- Journal Title
  
  Oxid Med Cell Longev.
  
  Volume: Article ID 6873281 Issue: 1 Pages: 14-14
- DOI
  10.1155/2017/6873281
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05845, KAKENHI-PROJECT-15H05684
[Journal Article] 敗血症における血栓形成の生理と病理2017
- Author(s)
  八島望, 伊藤隆史, 垣花泰之, 丸山征郎
- Journal Title
  
  日本外科感染症学会雑誌
  
  Volume: 14 Pages: 705-711
- Data Source
  KAKENHI-PROJECT-15H05684
[Journal Article] DAMP and DIC: The role of extracellular DNA and DNA-binding proteins in the pathogenesis of DIC2016
- Author(s)
  Patricia C. Liaw, Takashi Ito, Toshiaki Iba, Jecko Thachil, Sacha Zeerleder
- Journal Title
  
  Blood Reviews
  
  Volume: 印刷中 Issue: 4 Pages: 257-261
- DOI
  10.1016/j.blre.2015.12.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05684, KAKENHI-PROJECT-25462831
[Journal Article] Sepsis-induced myocardial dysfunction: pathophysiology and management2016
- Author(s)
  Yasuyuki Kakihana, Takashi Ito, Mayumi Nakahara, Keiji Yamaguchi1 and Tomotsugu 　 Yasuda
- Journal Title
  
  Journal of Intensive Care
  
  Volume: 4:22 Issue: 1 Pages: 1-10
- DOI
  10.1186/s40560-016-0148-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26861235, KAKENHI-PROJECT-15H05684
[Journal Article] Thrombomodulin as an intravascular safeguard against inflammatory and thrombotic diseases2016
- Author(s)
  Takashi Ito, Yasuyuki Kakihana & Ikuro Maruyama
- Journal Title
  
  Expert Opinion on Therapeutic Targets
  
  Volume: 20 Issue: 2 Pages: 151-158
- DOI
  10.1517/14728222.2016.1086750
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05684
[Journal Article] “DAMP and DIC: The role of extracellular DNA and DNA-binding proteins in the pathogenesis of DIC”2016
- Author(s)
  Liaw P, Ito T, Iba T, Thachil J, Zeerleder S
- Journal Title
  
  Blood Rev.
  
  Volume: 30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670793
[Journal Article] “DAMP and DIC: The role of extracellular DNA and DNA-binding proteins in the pathogenesis of DIC”2016
- Author(s)
  Liaw P, Ito T, Iba T, Thachil J, Zeerleder S
- Journal Title
  
  Blood Rev.
  
  Volume: 30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293387
[Journal Article] Potential diagnostic markers for disseminated intravascular coagulation of sepsis2016
- Author(s)
  Toshiaki Iba, Takashi Ito, Ikuro Maruyama, Bernd Jilma, Thorsten Brenner, Marcella C.A. Muller, Nicole P. Juffermans, Jecko Thachil
- Journal Title
  
  Blood Reviews
  
  Volume: 30 Issue: 2 Pages: 149-155
- DOI
  10.1016/j.blre.2015.10.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05684, KAKENHI-PROJECT-25462831, KAKENHI-PROJECT-15K15667, KAKENHI-PROJECT-26293385
[Journal Article] Diagnostic imaging of intra-abdominal cyst in heifer using the computed tomography2015
- Author(s)
  Otomaru, K., Fujikawa, T., Saito, Y., Ando, T., Obi, T., Miura, N., Kubota, C.
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: 77 Issue: 9 Pages: 1191-1193
- DOI
  10.1292/jvms.15-0153
- NAID
  130005100727
- ISSN
  0916-7250, 1347-7439
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26670793, KAKENHI-PROJECT-25305032, KAKENHI-PROJECT-26293387
[Journal Article] The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1β.2015
- Author(s)
  Fujita H, Yagishita N, Aratani S, Saito-Fujita T, Morota S, Yamano Y, Hansson MJ, Inazu M, Kokuba H, Sudo K, Sato E, Kawahara K, Nakajima F, Hasegawa D, Higuchi I, Sato T, Araya N, Usui C, Nishioka K, Nakatani Y, Maruyama I, Usui M, Hara N, Uchino H, Elmer E, Nishioka K, Nakajima T.
- Journal Title
  
  EMBO J.
  
  Volume: 34 Issue: 8 Pages: 1042-55
- DOI
  10.15252/embj.201489897
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24592282, KAKENHI-PROJECT-26293387, KAKENHI-PROJECT-26461476, KAKENHI-PROJECT-26670479, KAKENHI-PROJECT-26670793, KAKENHI-PROJECT-26461478, KAKENHI-PROJECT-26461961, KAKENHI-PROJECT-15K15091, KAKENHI-PROJECT-25860726, KAKENHI-PROJECT-25461293, KAKENHI-PROJECT-25461294, KAKENHI-PROJECT-15K15667, KAKENHI-PROJECT-24790898, KAKENHI-PROJECT-25305032, KAKENHI-PROJECT-26293385
[Journal Article] Cleavage of host cytokeratin-6 by lysine-specific gingipain induces gingival inflammation in periodontitis patients.2015
- Author(s)
  Tancharoen S, Matsuyama T, Kawahara K, Tanaka K, Lee LJ, Machigashira M, Noguchi K, Ito T, Imamura T, Potempa J, Kikuchi K,Maruyama I.
- Journal Title
  
  PLoS One.
  
  Volume: 10 Issue: 2 Pages: e0117775-e0117775
- DOI
  10.1371/journal.pone.0117775
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390402, KAKENHI-PROJECT-26293385, KAKENHI-PROJECT-26293387, KAKENHI-PROJECT-26670790, KAKENHI-PROJECT-26670793, KAKENHI-PROJECT-25460498
[Journal Article] Net effect of extracellular histones on septic disseminated intravascular coagulation2015
- Author(s)
  伊藤隆史, 垣花泰之
- Journal Title
  
  Journal of the Japanese Society of Intensive Care Medicine
  
  Volume: 22 Issue: 6 Pages: 499-504
- DOI
  10.3918/jsicm.22.499
- NAID
  130005107911
- ISSN
  1340-7988, 1882-966X
- Language
  Japanese
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H05684
[Journal Article] HMGB1 promotes the development of pulmonary arterial hypertension in rats.2014
- Author(s)
  Sadamura-Takenaka Y, Ito T, Noma S, Oyama Y, Yamada S, Kawahara K, Inoue H, Maruyama I.
- Journal Title
  
  PLoS One.
  
  Volume: 9 Issue: 7 Pages: e102482-e102482
- DOI
  10.1371/journal.pone.0102482
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390402, KAKENHI-PROJECT-25293192, KAKENHI-PROJECT-25305032, KAKENHI-PROJECT-26293387, KAKENHI-PROJECT-26670793
[Journal Article] Toxic effects of extracellular histones and their neutralization by vitreous in retinal detachment.2014
- Author(s)
  Kawano H, Ito T, Yamada S, Hashiguchi T, Maruyama I, Hisatomi T, Nakamura M, Sakamoto T.
- Journal Title
  
  Laboratory Investigations
  
  Volume: 94(5) Issue: 5 Pages: 569-585
- DOI
  10.1038/labinvest.2014.46
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390396, KAKENHI-PROJECT-24659282, KAKENHI-PROJECT-24659765, KAKENHI-PROJECT-25293132, KAKENHI-PROJECT-25670763, KAKENHI-PROJECT-26293385, KAKENHI-PROJECT-26670789
[Journal Article] PAMPs and DAMPs as triggers for DIC2014
- Author(s)
  Ito T
- Journal Title
  
  J Intensive Care
  
  Volume: 2 Issue: 1 Pages: 67-67
- DOI
  10.1186/s40560-014-0065-0
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390402, KAKENHI-PROJECT-26670789
[Journal Article] トロンボモジュリンの基礎2014
- Author(s)
  伊藤隆史
- Journal Title
  
  日本血栓止血学会誌
  
  Volume: 25(1) Pages: 55-60
- NAID
  130003393340
- Data Source
  KAKENHI-PROJECT-25670763
[Journal Article] Basic research on thrombomodulin2014
- Author(s)
  伊藤隆史
- Journal Title
  
  Japanese Journal of Thrombosis and Hemostasis
  
  Volume: 25 Issue: 1 Pages: 55-60
- DOI
  10.2491/jjsth.25.55
- NAID
  130003393340
- ISSN
  0915-7441, 1880-8808
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-24390402
[Journal Article] Hyaluronan protection of corneal endothelial cells against extracellular histones after phacoemulsification.2014
- Author(s)
  Kawano H, Sakamoto T, Ito T, Miyata K, Hashiguchi T, Maruyama I.
- Journal Title
  
  J Cataract Refract Surg
  
  Volume: 40 Issue: 11 Pages: 1885-93
- DOI
  10.1016/j.jcrs.2014.07.026
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24659765, KAKENHI-PROJECT-26670789, KAKENHI-PROJECT-26670790
[Journal Article] Roles of thrombomodulin as a nuclear safeguard2014
- Author(s)
  伊藤隆史
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 143 Issue: 1 Pages: 18-21
- DOI
  10.1254/fpj.143.18
- NAID
  130004827684
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-24390402
[Journal Article] Toxic effects of extracellular histones and their neutralization by vitreous in retinal detachment2014
- Author(s)
  Kawano H, Ito T, Yamada S, Hashiguchi T, Maruyama I, Hisatomi T, Nakamura M, Sakamoto T
- Journal Title
  
  Lab Invest
  
  Volume: 94(5) Pages: 569-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670763
[Journal Article] Potential of the angiotensin receptor blockers (ARBs) telmisartan, Irbesartan, and candesartan for inhibiting the HMGB1/RAGE axis in prevention and acute treatment of stroke.2013
- Author(s)
  Kikuchi K, Tancharoen S, Ito T, Morimoto-Yamashita Y, Miura N, Kawahara K, MaruyamaI, Murai Y, Tanaka E
- Journal Title
  
  Int. Mol. Sci.
  
  Volume: 14 Issue: 9 Pages: 18899-18924
- DOI
  10.3390/ijms140918899
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590269, KAKENHI-PROJECT-24390402, KAKENHI-PROJECT-24659804, KAKENHI-PROJECT-25305032
[Journal Article] Coagulation activity and white thrombus formation in the microminipig2013
- Author(s)
  Miura N, Kawaguchi H, Nagasato T, Yamada T, Ito T, Izumi H, Sameshima H, Miyoshi N, Tanimoto A, Maruyama I
- Journal Title
  
  In Vivo
  
  Volume: 27(3) Pages: 357-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390412
[Journal Article] Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism.2013
- Author(s)
  Nakahara M, Ito T, et al.
- Journal Title
  
  PLoS One
  
  Volume: 8(9) Issue: 9 Pages: 75961-75961
- DOI
  10.1371/journal.pone.0075961
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12F02424, KAKENHI-PROJECT-23390412, KAKENHI-PROJECT-24659282, KAKENHI-PROJECT-24659700, KAKENHI-PROJECT-24659804, KAKENHI-PROJECT-25293132, KAKENHI-PROJECT-25305032, KAKENHI-PROJECT-25670763, KAKENHI-PROJECT-25670764
[Journal Article] Analysing responses to aspirin and clopidogrel by measuring platelet thrombus formation under arterial flow conditions2013
- Author(s)
  Hosokawa K, Ohnishi T, Sameshima H, Miura N, Ito T, Koide T, Maruyama I
- Journal Title
  
  Thromb Haemost
  
  Volume: 109(1) Issue: 01 Pages: 102-11
- DOI
  10.1160/th12-06-0441
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390412, KAKENHI-PROJECT-24659798, KAKENHI-PROJECT-24659804
[Journal Article] Preventive effects of Morus alba L. anthocyanins on diabetes in Zucker diabetic fatty rats2013
- Author(s)
  Sarikaphuti A, Nararatwanchai T, Hashiguchi T, Ito T, Thaworanunta S, Kikuchi K, Oyama Y, Maruyama I, Tancharoen S
- Journal Title
  
  Exp Ther Med
  
  Volume: 6(3) Pages: 689-695
- URL
  http://www.spandidos-publications.com/etm/
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659804
[Journal Article] PAMPs/DAMPs as novel mediators of inflammation-associated thrombosis2013
- Author(s)
  伊藤隆史
- Journal Title
  
  Japanese Journal of Thrombosis and Hemostasis
  
  Volume: 24 Issue: 6 Pages: 675-679
- DOI
  10.2491/jjsth.24.675
- NAID
  130003393331
- ISSN
  0915-7441, 1880-8808
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-24390402
[Journal Article] PAMPs/DAMPs2013
- Author(s)
  伊藤隆史
- Journal Title
  
  International Review of Thrombosis
  
  Volume: 8 Pages: 74-76
- Data Source
  KAKENHI-PROJECT-24390402
[Journal Article] Saturated fatty acid palmitate induces extracellular release of histone H3 : a Possible mechanistic basis for high-fat diet-induced inflammation and thrombosis.2013
- Author(s)
  Shrestha C, Ito T, et al.
- Journal Title
  
  Biochemical and biophysical research communications
  
  Volume: 437(4) Issue: 4 Pages: 573-578
- DOI
  10.1016/j.bbrc.2013.06.117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12F02424, KAKENHI-PROJECT-24659282, KAKENHI-PROJECT-24659804, KAKENHI-PROJECT-25293132, KAKENHI-PROJECT-25670764
[Journal Article] Coagulation activity and white thrombus formation in the microminipig2013
- Author(s)
  Miura N, Kawaguchi H, Nagasato T, Yamada T, Ito T, Izumi H, Shameshima H, Miyoshi N, Tanimoto A, Maruyama I
- Journal Title
  
  In Vivo
  
  Volume: 27(3) Pages: 357-61
- URL
  http://iv.iiarjournals.org
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659804
[Journal Article] Recombinant Thrombomodulin Protects Mice against Histone-Induced Lethal Thromboembolism2013
- Author(s)
  Nakahara M, Ito T, Kawahara K, Yamamoto M, Nagasato T, Shrestha B, Yamada S, Miyauchi T, Higuchi K, Takenaka T, Yasuda T, Matsunaga A, Kakihana Y, Hashiguchi T, Kanmura Y, Maruyama I
- Journal Title
  
  PLoS One
  
  Volume: 8(9)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670763
[Journal Article] Paucity of CD34-positive cells and increased expression of high-mobility group box 1 in coronary thrombus with type 2 diabetes mellitus2012
- Author(s)
  Yamashita A, Nishihira K, Matsuura Y, Ito T, Kawahara K, Hatakeyama K, Hashiguchi T, Maruyama I, Yagi H, Matsumoto M, Fujimura Y, Kitamura K, Shibata Y, Asada Y.
- Journal Title
  
  Atherosclerosis
  
  Volume: 224(2) Pages: 511-514
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390179
[Journal Article] PAMPs/DAMPs2012
- Author(s)
  伊藤隆史
- Journal Title
  
  International Review of Thrombosis
  
  Volume: 8巻 Pages: 74-76
- Data Source
  KAKENHI-PROJECT-24659797
[Journal Article] Secondary prevention of stroke : Pleiotropic effects of optimal oral pharmacotherapy2012
- Author(s)
  Kikuchi K, Kawahara K, Miura N, Ito T, Morimoto Y, Tancharoen S, Takeshige N, Uchikado H, Sakamoto R, Miyagi N, Kikuchi C, Iida N, Shiomi N, Kuramoto T, Hirohata M, Maruyama I, Morioka M, Tanaka E
- Journal Title
  
  Exp Ther Med
  
  Volume: 4(1) Pages: 3-7
- URL
  http://www.spandidos-publications.com/etm/
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659804
[Journal Article] Paucity of CD34-positive cells and increased expression of high-mobility group box 1 in coronary thrombus with type 2 diabetes mellitus.2012
- Author(s)
  Yamashita A, Nishihira K, Matsuura Y, Ito T, Kawahara K, Hatakeyama K, Hashiguchi T, Maruyama I, Yagi H, Matsumoto M, Fujimura Y, Kitamura K, Shibata Y, Asada Y.
- Journal Title
  
  Atherosclerosis.
  
  Volume: 224 Issue: 2 Pages: 511-514
- DOI
  10.1016/j.atherosclerosis.2012.07.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591069, KAKENHI-PROJECT-23390412, KAKENHI-PROJECT-23591425, KAKENHI-PROJECT-23790410, KAKENHI-PROJECT-24659804
[Journal Article] Increased plasma levels of high mobility group box 1 in patients with acute liver failure2012
- Author(s)
  Oshima G, Shinoda M, Tanabe M, Ebinuma H, Nishiyama R, Takano K, Yamada S, Miyasho T, Masugi Y, Matsuda S, Suda K, Fukunaga K, Matsubara K, Hibi T, Yagi H, Hayashida T, Yamagishi Y, Obara H, Itano O, Takeuchi H, Kawachi S, Saito H, Hibi T, Maruyama I, Kitagawa Y
- Journal Title
  
  Eur Surg Res
  
  Volume: 48(3) Issue: 3 Pages: 154-62
- DOI
  10.1159/000338363
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390412, KAKENHI-PROJECT-23591875, KAKENHI-PROJECT-23791498, KAKENHI-PROJECT-24591888
[Journal Article] Thrombus formation and innate immunity2012
- Author(s)
  伊藤隆史
- Journal Title
  
  Japanese Journal of Thrombosis and Hemostasis
  
  Volume: 23 Issue: 3 Pages: 241-246
- DOI
  10.2491/jjsth.23.241
- NAID
  130002077019
- ISSN
  0915-7441, 1880-8808
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-24390402, KAKENHI-PROJECT-24659797
[Journal Article] HMGB1とトロンボモジュリン2012
- Author(s)
  伊藤隆史
- Journal Title
  
  Thrombosis Medicine
  
  Volume: 2 Pages: 18-22
- Data Source
  KAKENHI-PROJECT-23890166
[Journal Article] NETs (neutrophils extracellular traps)2012
- Author(s)
  伊藤隆史
- Journal Title
  
  Coagulation & Inflammation
  
  Volume: 6巻 Pages: 15-16
- Data Source
  KAKENHI-PROJECT-24659797
[Journal Article] 新規DIC 治療薬トロンボモジュリン製剤の作用機序2011
- Author(s)
  伊藤隆史, 丸山征郎
- Journal Title
  
  臨床血液
  
  Volume: 52巻 Pages: 356-360
- NAID
  130004501537
- Data Source
  KAKENHI-PROJECT-23390412
[Journal Article] Thrombomodulin : protectorate God of the vasculature in thrombosis and inflammation2011
- Author(s)
  Ito T, Maruyama I.
- Journal Title
  
  J Thromb Haemost
  
  Volume: 1 Pages: 168-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659491
[Journal Article] Thrombomodulin : protectorate God of the vasculature in thrombosis and inflammation J2011
- Author(s)
  Ito T, Maruyama I
- Journal Title
  
  Thromb Haemost
  
  Volume: 9 Pages: 168-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659491
[Journal Article] 新規DIC治療薬トロンボモジュリン製剤の作用機序2011
- Author(s)
  伊藤隆史、丸山征郎
- Journal Title
  
  臨床血液
  
  Volume: 52 Pages: 356-360
- NAID
  130004501537
- Data Source
  KAKENHI-PROJECT-23659491
[Journal Article] Thrombomodulin : protectorate God of the vasculature in thrombosis and inflammation2011
- Author(s)
  Ito T, Maruyama I.
- Journal Title
  
  J Thromb Haemost
  
  Volume: 9 Pages: 168-173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23890166
[Journal Article] 新規DIC治療薬トロンボモジュリン製剤の作用機序2011
- Author(s)
  伊藤隆史、丸山征郎
- Journal Title
  
  臨床血液
  
  Volume: 52 Pages: 356-360
- NAID
  130004501537
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23890166
[Journal Article] 新規DIC治療薬トロンボモジュリン製剤の作用機序2011
- Author(s)
  伊藤隆史・丸山征郎
- Journal Title
  
  臨床血液
  
  Volume: 第52巻6号 Pages: 356-360
- NAID
  130004501537
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23890166
[Journal Article] Thrombomodulin : protectorate God of the vasculature in thrombosis and inflammation2011
- Author(s)
  Ito T, Maruyama I
- Journal Title
  
  J Thromb Haemost
  
  Volume: Suppl 1 Pages: 168-73
- DOI
  10.1111/j.1538-7836.2011.04319.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390412, KAKENHI-PROJECT-23890166
[Journal Article] DAMPs/PAMPsと血栓形成2011
- Author(s)
  伊藤隆史
- Journal Title
  
  Thrombosis Medicine
  
  Volume: 1 Pages: 182-185
- Data Source
  KAKENHI-PROJECT-23890166
[Journal Article] Thrombomodulin : protectorate God of the vasculature in thrombosis and inflammation. J2011
- Author(s)
  Ito T, Maruyama I
- Journal Title
  
  Thromb Haemost
  
  Volume: 9 Pages: 168-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390412
[Journal Article] Thrombomodulin : protectorate God of the vasculature in thrombosis and inflammation2011
- Author(s)
  Takashi Ito & Ikuro Maruyama.
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume: 9 Pages: 168-173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659491
[Journal Article] B Cell-Derived Vascular Endothelial Growth Factor A Promotes Lymphangiogenesis and High Endothelial Venule Expansion in Lymph Nodes2010
- Author(s)
  Shrestha B, Hashiguchi T, Ito T, Miura N, Takenouchi K, Oyama Y, Kawahara K, Tancharoen S, Ki-I Y, Arimura N, Yoshinaga N, Noma S, Shrestha C, Nitanda T, Kitajima S, Arimura K, Sato M, Sakamoto T, Maruyama I
- Journal Title
  
  J Immunol
  
  Volume: 184 Pages: 4819-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells2009
- Author(s)
  Kikuchi K, Kawahara K, Tancharoen S, Matsuda F, Morimoto Y, Ito T, Biswas KK, Takenouchi K, Miura N, Oyama Y, Nawa Y, Arimura N, Iwata M, Tajima Y, Kuramoto T, Nakayama K, Shigemori M, Yoshida Y, Hashiguchi T, Maruyama I
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 329 Pages: 865-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] MK615 attenuates Porphyromonas gingivalis lipopolysaccharide-induced pro-inflammatory cytokine release via MAPK inactivation in murine macrophage-like RAW264.7 cells2009
- Author(s)
  Morimoto Y, Kikuchi K, Ito T, Tokuda M, Matsuyama T, Noma S, Hashiguchi T, Torii M, Maruyama I, Kawahara K
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 389 Pages: 90-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] Edaravone attenuates cerebral ischemic injury by suppressing aquaporin-42009
- Author(s)
  Kikuchi K, Tancharoen S, Matsuda F, Biswas KK, Ito T, Morimoto Y, Oyama Y, Takenouchi K, Miura N, Arimura N, Nawa Y, Meng X, Shrestha B, Arimura S, Iwata M, Mera K, Sameshima H, Ohno Y, Maenosono R, Tajima Y, Uchikado H, Kuramoto T, Nakayama K, Shigemori
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 390 Pages: 1121-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] Minocycline attenuates both OGD-induced HMGB1 release and HMGB1-induced cell death in ischemic neuronal injury in PC12 cells2009
- Author(s)
  Kikuchi K, Kawahara K, Biswas KK, Ito T, Tancharoen S, Morimoto Y, Matsuda F, Oyama Y, Takenouchi K, Miura N, Arimura N, Nawa Y, Meng X, Shrestha B, Arimura S, Iwata M, Mera K, Sameshima H, Ohno Y, Maenosono R, Yoshida Y, Tajima Y, Uchikado H, Kuramoto T
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 385 Pages: 132-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] Mechanism of HMGB1 release inhibition from RAW264.7 cells by oleanolic acid in Prunus mume Sieb. et Zucc2009
- Author(s)
  Kawahara K, Hashiguchi T, Masuda K, Saniabadi AR, Kikuchi K, Tancharoen S, Ito T, Miura N, Morimoto Y, Biswas KK, Nawa Y, Meng X, Oyama Y, Takenouchi K, Shrestha B, Sameshima H, Shimizu T, Adachi T, Adachi M, Maruyama I
- Journal Title
  
  Int J Mol Med
  
  Volume: 23 Pages: 615-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] Nucleophosmin may act as an alarmin : implications for severe sepsis2009
- Author(s)
  Nawa Y, Kawahara K, Tancharoen S, Meng X, Sameshima H, Ito T, Masuda Y, Imaizumi H, Hashiguchi T, Maruyama I
- Journal Title
  
  J Leukoc Biol
  
  Volume: 86 Pages: 645-53
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390483
[Journal Article] High-mobility group box 1 protein promotes development of microvascular thrombosis in rats2007
- Author(s)
  Ito T, Maruyama I, et. al.
- Journal Title
  
  J Thromb Haemost 5(1)
  
  Pages: 109-16
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390282
[Journal Article] High-mobility group box 1 protein promotes development of microvascular thrombosis in rats.2007
- Author(s)
  Takashi Ito et al.
- Journal Title
  
  Journal of Thrombosis and Haemostasis 5巻・1号
  
  Pages: 109-116
- Data Source
  KAKENHI-PROJECT-18791341
[Journal Article] High-mobility group box 1 protein promotes development ofmicrovascular thrombosis in rats.2007
- Author(s)
  Takashi Ito, et. al.
- Journal Title
  
  Journal of Thrombosis and Haemostasis 5巻・1号
  
  Pages: 109-116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791341
[Journal Article] HMGB1 High-mobility group box 12007
- Author(s)
  伊藤隆史, 丸山征郎
- Journal Title
  
  分子細胞治療 6巻・1号
  
  Pages: 68-69
- Data Source
  KAKENHI-PROJECT-18791341
[Journal Article] High-mobility group box 1 protein promotes development of microvascular thrombosis in rats.2007
- Author(s)
  Ito T, Maruyama I, et al.
- Journal Title
  
  J Thromb Haemost. 5(1)
  
  Pages: 109-16
- Data Source
  KAKENHI-PROJECT-17390282
[Journal Article] High-mobility group box 1 protein promotes development of microvascular thrombosis in rats.2007
- Author(s)
  Ito T, Maruyama I, et al.
- Journal Title
  
  J Thromb Haemost. 5(1)
  
  Pages: 109-116
- Data Source
  KAKENHI-PROJECT-17659294
[Journal Article] High-mobility group box ; protein promotes development of microvascula thrombosis in rats2007
- Author(s)
  Ito, T., Maruyama, I., et. al.
- Journal Title
  
  J Thromb Haemost(peer reviewed) 5(1)
  
  Pages: 109-16
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390282
[Presentation] 敗血症性臓器障害のメカニズムを紐解く ―DAMPsおよびNETsの関与を考える―2024
- Author(s)
  伊藤隆史
- Organizer
  第51回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-21H03033
[Presentation] 基礎研究から考える敗血症性DICの病態と治療2023
- Author(s)
  伊藤隆史
- Organizer
  第45回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-21H03033
[Presentation] 血管内恒常性維持とトロンボモジュリン2023
- Author(s)
  伊藤隆史
- Organizer
  第22回日本血管血流学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03033
[Presentation] 今あらためて考えるCOVID-19重症化2023
- Author(s)
  伊藤隆史
- Organizer
  第45回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-21H03033
[Presentation] 血管内における炎症と凝固のクロストーク2023
- Author(s)
  伊藤隆史
- Organizer
  第43回日本川崎病学会・学術集会
- Data Source
  KAKENHI-PROJECT-21H03033
[Presentation] 血流下での血小板機能解析の意義と可能性2022
- Author(s)
  伊藤隆史
- Organizer
  第62回日本臨床化学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21H03033
[Presentation] 敗血症/無菌性炎症におけるDAMPsの動態と病態2022
- Author(s)
  伊藤隆史
- Organizer
  第50回日本救急医学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03033
[Presentation] 炎症と凝固のクロストーク　侵襲に対する原始応答の生理と病理2022
- Author(s)
  伊藤隆史
- Organizer
  第69回日本麻酔科学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03033
[Presentation] 敗血症性DICにおける臓器障害/予後予測因子としてのcirculating histone H32022
- Author(s)
  伊藤隆史
- Organizer
  第23回日本検査血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21H03033
[Presentation] 血管内皮細胞の抗血栓性と血管内凝固2022
- Author(s)
  伊藤隆史
- Organizer
  第44回日本血栓止血学会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03033
[Presentation] 侵襲応答と臓器障害 up-to-date2021
- Author(s)
  伊藤隆史
- Organizer
  第49回日本集中治療医学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03033
[Presentation] 敗血症-好中球-ヒストン-DIC 連関の基礎と臨床2021
- Author(s)
  伊藤隆史
- Organizer
  第49回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-21H03033
[Presentation] 好中球の生理と病理と臓器障害2020
- Author(s)
  伊藤　隆史
- Organizer
  第48回日本救急医学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18H02904
[Presentation] 目で視て考える侵襲に対する宿主応答と臓器障害2020
- Author(s)
  伊藤隆史
- Organizer
  第47回日本集中治療医学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02904
[Presentation] ダメージ関連分子パターン（DAMPs）の解析と応用展開2020
- Author(s)
  伊藤　隆史
- Organizer
  第67回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02904
[Presentation] 敗血症におけるテトラヒドロビオプテリン及びその酸化物の体内変化とNOxとの関係2020
- Author(s)
  政所祐太郎、上國料千夏、伊藤隆史、江口智洋、古別府裕明、新山修平、安田智嗣、垣花泰之
- Organizer
  第４７回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09438
[Presentation] Endotheliopathy in septic conditions2020
- Author(s)
  Ito Takashi
- Organizer
  International Society on Thrombosis and Haemostasis 2020 Virtual Congress
- Data Source
  KAKENHI-PROJECT-18H02904
[Presentation] 救急疾患に伴う凝固線溶異常のオーバービュー2020
- Author(s)
  伊藤　隆史
- Organizer
  第42回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02904
[Presentation] ヒストンH2AとH2BはMD2/ERK1/2を介してTNF-αを誘導する2020
- Author(s)
  上野光理, Ronny Christiadi Salim, 石濱一貴, 朝田成重, 山下侑子, Tancharoen Salunya, 菊池清志, 伊藤隆史, 丸山征郎, 川原幸一
- Organizer
  第42回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02906
[Presentation] 細胞外Nucleophosminの受容体は TLR-4である2020
- Author(s)
  中富康太, 董建暉, 金本一誠, Ronny Christiadi Salim, 上野光理, Salunya Tancharoen, 菊池清志伊藤隆史, 丸山征郎, 川原幸一
- Organizer
  日本薬学会
- Data Source
  KAKENHI-PROJECT-18H02906
[Presentation] Mechanism-based anticoagulant strategy in sepsis-associated DIC2020
- Author(s)
  伊藤隆史
- Organizer
  第47回日本集中治療医学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02904
[Presentation] TNF-a induction by Histone H2A and H2B is mediated via ERK1/2 in RAW264.7 cells.2019
- Author(s)
  Hikari Ueno, Kota Nakatomi, Shuto Anan, Salunya Tancharoen, Kiyoshi Kikuchi, Takashi Ito, Ikuro Maruyama, Ko-ichi Kawahara
- Organizer
  International DAMPs and Alarmins Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02906
[Presentation] Circulating histone H3 as an indicator/inducer of DIC and organ failure2019
- Author(s)
  Takashi Ito
- Organizer
  9th International DAMPs and Alarmins Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02904
[Presentation] Plasma activated protein C activity in the presence of recombinant thrombomodulin in vivo and in vitro2019
- Author(s)
  Takashi Ito
- Organizer
  ISTH 2019: The XXVII Congress of the International Society on Thrombosis and Haemostasis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02904
[Presentation] The extracellular Nucleophosmin Receptor is TLR-42019
- Author(s)
  Kota Nakatomi, Ronny Christiadi Salim, Issey Kanemoto, Hikari Ueno, Dong Jianhui, Salunya Tancharoen, Kiyoshi Kikuchi, Takashi Ito, Ikuro Maruyama, Ko-ichi Kawahara.
- Organizer
  International DAMPs and Alarmins Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02906
[Presentation] 図解　敗血症学2019
- Author(s)
  伊藤隆史
- Organizer
  第120回近畿救急医学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02904
[Presentation] 敗血症病態における血栓形成の光と影2019
- Author(s)
  伊藤隆史
- Organizer
  第46回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02904
[Presentation] 目で視る敗血症性DICの病態2018
- Author(s)
  伊藤隆史
- Organizer
  第117回近畿救急医学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-15H05684
[Presentation] 凝固/抗凝固反応はどこで起きているのか cell-based model の紹介2018
- Author(s)
  伊藤隆史
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02904
[Presentation] Leukocyte-derived extracellular DNA as an underlying cause of extracorporeal circuit obstruction2018
- Author(s)
  Takashi Ito
- Organizer
  International Society on Thrombosis and Haemostasis SSC meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02904
[Presentation] 敗血症病態における予後予測因子の探索2018
- Author(s)
  横山弥生、伊藤隆史、上國料千夏、畠中耕作、古別府裕明、安田智嗣、垣花泰之
- Organizer
  第45回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-15H05684
[Presentation] 遺伝子組換えトロンボモジュリン製剤の効果を引き出すにあたって凝固検査は有用か？2018
- Author(s)
  八島望, 伊藤隆史
- Organizer
  第12回日本血栓止血学会SSCシンポジウム
- Data Source
  KAKENHI-PROJECT-15H05684
[Presentation] 敗血症診療における急性期DIC診断基準の意義2018
- Author(s)
  伊藤隆史、横山弥生、上國料千夏、宮本昇太郎、政所祐太郎、寺田晋作、江口智洋、中村隼人、安田智嗣、垣花泰之
- Organizer
  第45回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-15H05684
[Presentation] 敗血症の病態を形づくるもの2017
- Author(s)
  伊藤隆史
- Organizer
  第11回日本血栓止血学会SSCシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-15H05684
[Presentation] 敗血症性DICにおける血栓形成の生理と病理2017
- Author(s)
  伊藤隆史
- Organizer
  第44回日本集中治療医学会学術集会
- Place of Presentation
  ホテルさっぽろ芸文館（北海道札幌市）
- Invited
- Data Source
  KAKENHI-PROJECT-15H05684
[Presentation] 肺塞栓からショックを引き起こした遅発型ヘパリン起因性血小板減少症(HIT)の一例2017
- Author(s)
  中弁護, 伊藤隆史, 新門翠, 久保祐輝, 馬場敬太, 政所祐太郎, 宮本昇太郎, 江口智洋, 寺田晋作, 垣花泰之
- Organizer
  第44回日本集中治療医学会学術集会
- Place of Presentation
  ロイトン札幌（北海道札幌市）
- Data Source
  KAKENHI-PROJECT-16K15764
[Presentation] 核由来DAMPs/alarminsによる血管内血栓形成2017
- Author(s)
  伊藤隆史
- Organizer
  第４９回日本動脈硬化学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-15H05684
[Presentation] 本邦 ICU における HIT 発症頻度の解析ならびに新規検査法の展望2017
- Author(s)
  伊藤隆史, 上國料千夏, 安田智嗣, 垣花泰之
- Organizer
  第44回日本集中治療医学会学術集会
- Place of Presentation
  ホテルさっぽろ芸文館（北海道札幌市）
- Data Source
  KAKENHI-PROJECT-16K15764
[Presentation] 血液凝固の基礎とトロンボモジュリンの意義2016
- Author(s)
  伊藤隆史
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Invited
- Data Source
  KAKENHI-PROJECT-15H05684
[Presentation] Anti-inflammatory and anticoagulant roles of thrombomodulin in sepsis-associated DIC2016
- Author(s)
  Takashi Ito, and Ikuro Maruyama
- Organizer
  1st joint Meeting of ISFP and PA workshop
- Place of Presentation
  日本平ホテル（静岡県静岡市）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05684
[Presentation] CalDAG-GEFI分子異常により血小板機能異常を呈した一症例2016
- Author(s)
  古城剛, 山口宗一, 吉村明子, 竹之内和則, 伊藤隆, 清水利昭, 大山陽子, 郡山豊泰, Panta Sushil, 松下昌風, 丸山征郎, 高嶋博, 橋口照人
- Organizer
  第63回日本臨床検査医学会学術集会
- Place of Presentation
  神戸国際会議場(兵庫県神戸市）
- Year and Date
  2016-09-01
- Data Source
  KAKENHI-PROJECT-15K15196
[Presentation] 好中球→NETs→ヒストンと敗血症性臓器障害2016
- Author(s)
  伊藤隆史
- Organizer
  第44回日本救急医学会総会・学術集会
- Place of Presentation
  グランドプリンスホテル新高輪国際館パミール（東京都港区）
- Invited
- Data Source
  KAKENHI-PROJECT-15H05684
[Presentation] Thrombin-thrombomodulin system in the hemostatic system and its clinical implication2016
- Author(s)
  Ikuro Maruyama,and Takashi Ito
- Organizer
  The 1st Joint Meeting of ISFP/PA Workshop
- Place of Presentation
  日本平ホテル(静岡県静岡市)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15763
[Presentation] CalDAG-GEFI分子異常により血小板機能異常を呈した一症例2016
- Author(s)
  古城剛, 山口宗一, 吉村明子, 竹之内和則, 伊藤隆史, 清水利昭, 大山陽子, 郡山豊泰, Sushil Panta, 松下昌風, 丸山征郎, 高嶋博, 橋口照人
- Organizer
  第38回日本血栓止血学会学術集会
- Place of Presentation
  奈良春日野国際フォーラム（奈良県奈良市）
- Year and Date
  2016-06-16
- Data Source
  KAKENHI-PROJECT-15K15196
[Presentation] The successful venoarterial extracorporeal membrane oxygenation tretment in a child with repetitive fulminant myocarditis2016
- Author(s)
  Y. Madokoro, T. Yasuda, S. Miyamoto, S. Terada, H. Haraura, M. Arima, T. Ito, M. Nakahara, T. Futatsuki, J. Taniguchi, K. Yanagimoto, K. Yamaguchi, Y. Kakihana
- Organizer
  8th World Congress on Pediatric Intensive and Critical Care
- Place of Presentation
  Metro Toronto Convention Centre (Toronto, Canada)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26861235
[Presentation] 敗血症性DICの病態における好中球と血管内皮細胞傷害2016
- Author(s)
  伊藤隆史
- Organizer
  第38回日本血栓止血学会学術集会
- Place of Presentation
  奈良春日野国際フォーラム（奈良県奈良市）
- Invited
- Data Source
  KAKENHI-PROJECT-15H05684
[Presentation] Clinical implication of visualizing platelet adhesion, aggregation, and activation in a microchip-based flow chamber system2016
- Author(s)
  伊藤隆史
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  東北大学川内北キャンパス（宮城県仙台市）
- Data Source
  KAKENHI-PROJECT-16K15764
[Presentation] 敗血症において細胞外ヒストンは主に好中球に由来する2016
- Author(s)
  中原真由美、伊藤隆史、安田智嗣、垣花泰之、丸山征郎、上村裕一
- Organizer
  日本麻酔科学会第63回学術集会
- Place of Presentation
  マリンメッセ福岡（福岡県福岡市）
- Data Source
  KAKENHI-PROJECT-26861235
[Presentation] Uncontrolled immunothrombosis as a basis of sepsis-associated DIC2016
- Author(s)
  Takashi Ito
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-10
- Data Source
  KAKENHI-PROJECT-15H05684
[Presentation] 敗血症性血管内皮細胞障害とNETs2016
- Author(s)
  伊藤隆史
- Organizer
  第38回日本呼吸療法医学会学術集会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Invited
- Data Source
  KAKENHI-PROJECT-15H05684
[Presentation] 敗血症性DICにおけるヒストンのnet effect2015
- Author(s)
  伊藤隆史
- Organizer
  第42回日本集中治療医学会学術集会
- Place of Presentation
  東京都（ホテル日航東京）
- Year and Date
  2015-02-10
- Invited
- Data Source
  KAKENHI-PROJECT-24390402
[Presentation] 敗血症性DICの病態を再考する～immunothrombosisの役割～2015
- Author(s)
  伊藤隆史
- Organizer
  第37回日本血栓止血学会学術集会
- Place of Presentation
  甲府市総合市民会館（山梨県甲府市）
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-15H05684
[Presentation] Protective roles of thrombomodulin in nuclear DAMPs-associated thrombosis2015
- Author(s)
  伊藤隆史
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  金沢市アートホール（石川県金沢市）
- Year and Date
  2015-10-17
- Invited
- Data Source
  KAKENHI-PROJECT-15H05684
[Presentation] 血栓と免疫、そして、その制御2014
- Author(s)
  伊藤隆史
- Organizer
  第41回日本集中治療医学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25670763
[Presentation] Extracellular histones and HMGB1in sepsis-associated coagulopathy2014
- Author(s)
  Ito T
- Organizer
  HMGB1 workshop in Stockholm
- Place of Presentation
  Sweden, Stockholm（Royal Park Hotel)
- Year and Date
  2014-09-30
- Data Source
  KAKENHI-PROJECT-24390402
[Presentation] DIC/TMAの新規メディエーター：ヒストン2014
- Author(s)
  伊藤隆史
- Organizer
  第36回日本血栓止血学会学術集会　(JSTH・救急医学会ジョイントシンポジウム)
- Place of Presentation
  大阪府・大阪市(大阪国際交流センター）
- Year and Date
  2014-05-30
- Invited
- Data Source
  KAKENHI-PROJECT-24390402
[Presentation] DIC/TMAの新規メディエーター：ヒストン2014
- Author(s)
  伊藤隆史
- Organizer
  第36回日本血栓止血学会学術集会　(JSTH・救急医学会ジョイントシンポジウム)
- Place of Presentation
  大阪府・大阪市(大阪国際交流センター）
- Year and Date
  2014-05-30
- Invited
- Data Source
  KAKENHI-PROJECT-26670789
[Presentation] Assay method of des-HMGB12013
- Author(s)
  Ikuro Maruyama, Takashi Ito, Yoshio Azuma, Mayumi Nakahara, Teruto Hashiguchi, Shingo Yamada
- Organizer
  N-terminus cleaved out HMGB1 by thrombin-thrombomodulin, and its clinical significance XXIVcongress of the ISTH
- Place of Presentation
  Amsterdam, The Netherlands
- Data Source
  KAKENHI-PROJECT-25670764
[Presentation] Assay method of des-HMGB1, N-terminus cleaved out HMGB1 by thrombinthrombomodulin, and its clinical significance2013
- Author(s)
  Ikuro Maruyama, Takashi Ito, Yoshio Azuma, Mayumi Nakahara, Teruto Hashiguchi, Shingo Yamada
- Organizer
  XXIVcongress of the ISTH
- Place of Presentation
  Amsterdam, The Netherlands
- Data Source
  KAKENHI-PROJECT-23390412
[Presentation] 生体侵襲性HMGB1-RAGEシステムと遺伝子組換えトロンボモジュリンによるインターベンション2013
- Author(s)
  伊藤隆史
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡県福岡市(招待講演)
- Data Source
  KAKENHI-PROJECT-24390402
[Presentation] 炎症に起因する血栓症の病態解明～新規メディエーターとしてのPAMPs・DAMPs～2013
- Author(s)
  伊藤隆史
- Organizer
  第35回日本血栓止血学会学術集会
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-25670763
[Presentation] Massive thrombosis evoked by extracellular histones : Is it DIC?2013
- Author(s)
  Takashi Ito, Mayumi Nakahara, and Ikuro Maruyama
- Organizer
  59th Scientific and Standardization Committee Meeting of the ISTH 2013
- Place of Presentation
  オランダ.
- Data Source
  KAKENHI-PROJECT-25670763
[Presentation] 死細胞由来分子によって引き起こされる凝固異常とその制御2013
- Author(s)
  伊藤隆史
- Organizer
  第40回日本集中治療医学会学術集会
- Place of Presentation
  長野県松本市(招待講演)
- Data Source
  KAKENHI-PROJECT-24390402
[Presentation] Assay method of Des-HMGB1, N-terminus cleaved out HMGB1 by thrombin-thrombomodulin and its clinical significance2013
- Author(s)
  kuro Maruyama, Takashi Ito, Shigo Yamada
- Organizer
  XXIV Congress of the ISTH
- Data Source
  KAKENHI-PROJECT-24659798
[Presentation] 炎症に起因する血栓症の病態解明~新規メディエーターとしてのPAMPs・DAMPs~2013
- Author(s)
  伊藤隆史
- Organizer
  第35回血栓止血学会
- Place of Presentation
  山形
- Year and Date
  2013-05-30
- Data Source
  KAKENHI-PROJECT-24659804
[Presentation] 死細胞由来分子によって引き起こされる凝固異常とその制御2013
- Author(s)
  伊藤隆史
- Organizer
  第40回日本集中治療医学会学術集会
- Place of Presentation
  長野県
- Data Source
  KAKENHI-PROJECT-24659797
[Presentation] 死細胞由来分子によって引き起こされる凝固異常とその制御2013
- Author(s)
  伊藤隆史
- Organizer
  第40回日本集中治療医学会学術集会
- Place of Presentation
  長野県・松本市
- Invited
- Data Source
  KAKENHI-PROJECT-24659797
[Presentation] PAMPs/DAMPs から紐解く「敗血症の病態生理」と「トロンボモジュリンのポテンシャル」2012
- Author(s)
  伊藤隆史
- Organizer
  第34回日本血栓止血学会学術集会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24659797
[Presentation] The Prothrombotic Roles of PAMPs and DAMPs2012
- Author(s)
  伊藤隆史
- Organizer
  第34回日本血栓止血学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24390402
[Presentation] DAMPsによる血栓形成とトロンボモジュリンによるその制御2012
- Author(s)
  伊藤隆史
- Organizer
  第39回日本集中治療医学会学術集会
- Place of Presentation
  幕張メッセ、千葉市(招待講演)
- Year and Date
  2012-02-28
- Data Source
  KAKENHI-PROJECT-23890166
[Presentation] The Prothrombotic Roles of PAMPs and DAMPs2012
- Author(s)
  伊藤隆史
- Organizer
  第34回日本血栓止血学会学術集会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-24659797
[Presentation] 免疫B細胞発現VEGF-Aによるリンパ節リモデリングと免疫環境の機能的制2012
- Author(s)
  橋口照人、伊藤隆史、SHRESTHA B、三浦直樹、丸山征郎
- Organizer
  第34回日本血栓止血学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22390179
[Presentation] PAMPs/DAMPsから紐解く「敗血症の病態生理」と「トロンボモジュリンのポテンシャル」2012
- Author(s)
  伊藤隆史
- Organizer
  第34回日本血栓止血学会学術集会
- Place of Presentation
  東京(招待講演)
- Data Source
  KAKENHI-PROJECT-24390402
[Presentation] The Prothrombotic Roles of PAMPs and DAMPs2012
- Author(s)
  伊藤隆史
- Organizer
  第34回日本血栓止血学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24659797
[Presentation] Extracellular histones are eliciting factors for DIC2012
- Author(s)
  Takashi Ito
- Organizer
  58th Scientific and Standardization Committee Meeting of the ISTH 2012
- Place of Presentation
  イギリス・リバプール
- Data Source
  KAKENHI-PROJECT-24659797
[Presentation] DAMPsによる血栓形成とトロンボモジュリンによるその制御2012
- Author(s)
  伊藤隆史
- Organizer
  第39回日本集中治療医学会学術集会(イブニングセミナー3第2回HMGB1シンポジウム)
- Place of Presentation
  千葉市
- Year and Date
  2012-02-28
- Data Source
  KAKENHI-PROJECT-23890166
[Presentation] Recombinant thrombomodulin and HMGB12011
- Author(s)
  Ito T, and Maruyama I.
- Organizer
  American Heart Association Scientific Sessions 2011(Cardiovascular Seminar CVS. 705)
- Place of Presentation
  米国オーランド
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-23890166
[Presentation] Recombinant Thrombomodulin and HMGB12011
- Author(s)
  Takashi Ito
- Organizer
  American Heart Association Scientific Sessions
- Place of Presentation
  Orlando, FL, USA(招待講演)
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-23890166
[Presentation] HMGB1 promotes development of DIC in rats2007
- Author(s)
  伊藤隆史
- Organizer
  国際血栓止血学会
- Place of Presentation
  ジュネーブ(スイス)
- Data Source
  KAKENHI-PROJECT-18791341
[Presentation] Hemophagocytosis as a process of fine tuning immune system in vivo
- Author(s)
  Shrestha Binita　伊藤隆史　郡山豊泰　竹之内和則　大山陽子　清水利昭　山口宗一　丸山征郎　橋口照人
- Organizer
  第61回　日本臨床検査医学会学術集会
- Place of Presentation
  福岡国際会議場（福岡県）
- Year and Date
  2014-11-22 – 2014-11-25
- Data Source
  KAKENHI-PROJECT-24659282
[Presentation] Extracellular histones and HMGB1 in sepsis-associated coagulopathy
- Author(s)
  Ito T
- Organizer
  HMGB1 workshop in Stockholm
- Place of Presentation
  Sweden, Stockholm（Royal Park Hotel)
- Year and Date
  2014-09-30 – 2014-10-01
- Data Source
  KAKENHI-PROJECT-26670789
[Presentation] 敗血症性 DIC におけるヒストンの net effect
- Author(s)
  伊藤隆史
- Organizer
  第42回日本集中治療医学会学術集会
- Place of Presentation
  東京都（ホテル日航東京）
- Year and Date
  2015-02-09 – 2015-02-11
- Invited
- Data Source
  KAKENHI-PROJECT-26670789
[Presentation] Novel Insight of B Cell-Derived VEGF-A: Fine Tuning the Immune Response Through Hemophagocytosis
- Author(s)
  Binita Shrestha, Takashi Ito, Naoki Miura, Kazunori Takenouchi, Sushil Panta, Munekazu Yamakuchi, Ikuro Maruyama, Teruto Hashiguchi
- Organizer
  44th Annual Meeting of the German Society for Immunology
- Place of Presentation
  BONN (Germany)
- Year and Date
  2014-09-17 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-24659282

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ITO Takashi 伊藤 隆史

Research Projects

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DAMPsサブタイプ特異的抗体を駆使した敗血症の階層化と分子標的治療技術の構築Principal Investigator

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Reconstruction of metabolism in sepsis by targeting gut microbiotaPrincipal Investigator

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A novel therapeutic strategy targeting HMGB1 isoforms in sepsisPrincipal Investigator

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ITO Takashi 伊藤隆史