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Komatsu Yasuo  小松 康雄

… Alternative Names

KOMATSU Yasuo  小松 康雄

(KOMATSU Yasuo  小松 康雄

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Researcher Number 30271670
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-9258-8275
External Links
Affiliation (Current) 2025: 国立研究開発法人産業技術総合研究所, 生命工学領域, 領域長補佐
Affiliation (based on the past Project Information) *help 2020 – 2023: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究部門長
2018 – 2021: 国立研究開発法人産業技術総合研究所, 生命工学領域, 副研究部門長
2016 – 2019: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究グループ付
2016: 国立研究開発法人産業技術総合研究所, 生物プロセス研究部門, 研究員
2015 – 2016: 国立研究開発法人産業技術総合研究所, 生物プロセス研究部門, 研究グループ長 … More
2013 – 2014: 独立行政法人産業技術総合研究所, 生物プロセス研究部門, 研究グループ長
2010 – 2011: 独立行政法人産業技術総合研究所, 生物プロセス研究部門, 研究グループ長
2005 – 2009: 独立行政法人産業技術総合研究所, ゲノムファクトリー研究部門, 研究グループ長
2004: National Institute of Advanced Industrial Science and Technology, Research Institute of Genome-based Biofactory, Group Leader, ゲノムファクトリー研究部門, グループ長
2004: 独立行政法人産業技術総合研究所, ゲノムファクトリー研究部門, 主任研究員
2003: 独立行政法人産業技術総合研究所, 生物機能工学研究部門, 主任研究員
2000: 北大, 薬学研究科, 助手
1995 – 1999: 北海道大学, 薬学部, 助手
1998: 北海道大学, 大学院・薬学研究科, 助手 Less
Review Section/Research Field
Principal Investigator
Living organism molecular science / Biological pharmacy / Drug development chemistry / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Analytical chemistry
Except Principal Investigator
Basic Section 63030:Chemical substance influence on environment-related / Medium-sized Section 47:Pharmaceutical sciences and related fields / Risk sciences of radiation and chemicals / Drug development chemistry / 医薬分子機能学
Keywords
Principal Investigator
RNA / オリゴヌクレオチド / 核酸 / oligonucleotide / siRNA / miRNA / クロスリンク / 核酸医薬 / アンチセンス / DNA … More / 遺伝子 / OPN / microRNA / 酵素 / 遺伝子治療 / リボザイム / RNA酵素 / antisense / oligonucleotide therapy / microarray / gene detection / amino / DNA chip / nucleic acid / マイクロアレイ / 遺伝子検出 / アミノ基 / DNAチップ / hepatitis / concanavarin A / metastasis / Osteopontin / リン酸化糖タンパク質 / 炎症疾患 / RNAi / 癌転移 / Concanavalin A / 肝炎 / concanavalin A / 転移 / オステオポンチン / グルコースオキシダーゼ / グルコース / 電気化学 / バイオセンサー / 連結 / 疎水的相互作用 / 安定化 / アミノオキシ / 架橋 / 定量 / 検出 / ヒト誘導型-酸化窒素合成酵素 … More
Except Principal Investigator
遠隔作用変異 / DNA損傷 / ペプチドミメティクス / 三次元多様性 / シクロプロパン / RNA / APOBEC3 / 8-hydroxyguanine / 高分子間相互作用 / αヘリックス / ホールダマー / 膜透過性ペプチド / 環状ペプチド / タンパク質間相互作用 / DNA 損傷 / ペプチドミイメティクス / ライブラリー / ヌクレオシド / レゾルビン / splicing / hammerhead ribozyme / group I introns / RNP / snRNA / catakytic RNA / ribozyme / catalyticRNA / スプライシング / 反応機構 / 分子設計 / 酵素 / 23SリボソームRNA / RNase P / U6snRNA / マキシザイム / GNRA-receptor 4 / G167 / ンマーヘッド型リボザイム / ヘアピン型リボザイム / スプライソソーム / リボソーム / snRNP / ハンマーヘッド型リボザイム / 分子デザイン / グループIイントロン / リボザイム / ELISA / Dewar isomer / (6-4) photo product / thymine dimer / single-chain antibody / monoclonal antibody / UV-damaged DNA / Dewar型変性体 / ELISA法 / Dewar型異性体 / (6-4)光産物 / チミンダイマー / 一本鎖抗体 / モノクローナル抗体 / 紫外線損傷DNA Less
  • Research Projects

    (17 results)
  • Research Products

    (134 results)
  • Co-Researchers

    (33 People)
  •  Complex formation between RNA cleaving-enzyme and antisense and its application to regulation of long non-coding RNAs.Principal Investigator

    • Principal Investigator
      Yasuo Komatsu
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
    • Research Institution
      National Institute of Advanced Industrial Science and Technology
  •  Medicinal chemistry for developing molecules regulating interactions between biological macromolecules

    • Principal Investigator
      Shuto Satoshi
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 47:Pharmaceutical sciences and related fields
    • Research Institution
      Hokkaido University
  •  Molecular mechanisms of action-at-a-distance mutations induced by DNA damage

    • Principal Investigator
      KAMIYA Hiroyuki
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 63030:Chemical substance influence on environment-related
    • Research Institution
      Hiroshima University
  •  Molecular mechanisms of action-at-a-distance mutations

    • Principal Investigator
      KAMIYA Hiroyuki
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Risk sciences of radiation and chemicals
    • Research Institution
      Hiroshima University
  •  Development of anti-miRNA oligonucleotides on the basis of structure control.Principal Investigator

    • Principal Investigator
      Komatsu Yasuo
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      National Institute of Advanced Industrial Science and Technology
  •  Medicinal chemistry studies based on the three-dimensional structural diversity-oriented molecular design of pharmacologically active compounds

    • Principal Investigator
      Shuto Satoshi
    • Project Period (FY)
      2015 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Drug development chemistry
    • Research Institution
      Hokkaido University
  •  Development of anti-miRNA oligonucleotides with stable duplexes to control cardiac diseases.Principal Investigator

    • Principal Investigator
      Komatsu Yasuo
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      National Institute of Advanced Industrial Science and Technology
  •  Development of bienzyme immobilized electrode by using interstrand cross-linked DNAs.Principal Investigator

    • Principal Investigator
      KOMATSU Yasuo
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Analytical chemistry
    • Research Institution
      National Institute of Advanced Industrial Science and Technology
  •  Development of DNA-interstrand cross-linking compounds and application to DNA scaffoldPrincipal Investigator

    • Principal Investigator
      KOMATSU Yasuo
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Living organism molecular science
    • Research Institution
      National Institute of Advanced Industrial Science and Technology
  •  Development of labeling reagents for quantitative RNA detectionPrincipal Investigator

    • Principal Investigator
      (KOMATSU Yasuo
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Living organism molecular science
    • Research Institution
      National Institute of Advanced Industrial Science and Technology
  •  Development of immobilization technology of biologically-relavant moleculeand its applicationPrincipal Investigator

    • Principal Investigator
      KOMATSU Yasuo
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Living organism molecular science
    • Research Institution
      NATIONAL INSTITUTE OFADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
  •  Investigation of regulatory mechanism of homeostasis using functional nucleic acids.Principal Investigator

    • Principal Investigator
      KOMATSU Yasuo, 大塚 榮子
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Living organism molecular science
    • Research Institution
      NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
  •  遺伝子治療への応用を目指した新規RNA酵素の開発Principal Investigator

    • Principal Investigator
      小松 康雄
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Biological pharmacy
    • Research Institution
      Hokkaido University
  •  RNA酵素の遺伝子治療への応用のための研究Principal Investigator

    • Principal Investigator
      小松 康雄
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Biological pharmacy
    • Research Institution
      Hokkaido University
  •  Researches on ribozymes at molecular and atomic level

    • Principal Investigator
      INOUE Tan
    • Project Period (FY)
      1997 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kyoto University
  •  RNA酵素の高活性化に関する研究Principal Investigator

    • Principal Investigator
      小松 康雄
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Biological pharmacy
    • Research Institution
      Hokkaido University
  •  Recognition of DNA by thymine dimers specific antibodies

    • Principal Investigator
      INOUE Hideo, 大塚 栄子
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      医薬分子機能学
    • Research Institution
      Hokkaido University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book Patent

  • [Book] 共有結合型DNAチップの開発,「新しいDNAチップの科学と応用」2007

    • Author(s)
      小松康雄
    • Publisher
      講談社(東京)
    • Data Source
      KAKENHI-PROJECT-19510230
  • [Journal Article] Promotion of cytoplasmic localization of oligonucleotides by connecting cross-linked duplexes2022

    • Author(s)
      Hirano Yu、Komatsu Yasuo
    • Journal Title

      RSC Advances

      Volume: 12 Issue: 38 Pages: 24471-24477

    • DOI

      10.1039/d2ra04375k

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K05123, KAKENHI-PROJECT-20H03372
  • [Journal Article] Biased distribution of action-at-a-distance mutations by 8-oxo-7,8-dihydroguanine2022

    • Author(s)
      Ruriko Fukushima, Tetsuya Suzuki, Yasuo Komatsu, Hiroyuki Kamiya
    • Journal Title

      Mutation research (Fundamental and Molecular Mechanisms of Mutagenesis)

      Volume: 825 Pages: 111794-111794

    • DOI

      10.1016/j.mrfmmm.2022.111794

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K12181, KAKENHI-PROJECT-20H03372
  • [Journal Article] Synthesis of crosslinked 2′-OMe RNA duplexes and their application for effective inhibition of miRNA function2021

    • Author(s)
      Abdelhady Ahmed Mostafa、Hirano Yu、Onizuka Kazumitsu、Okamura Hidenori、Komatsu Yasuo、Nagatsugi Fumi
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 48 Pages: 128257-128257

    • DOI

      10.1016/j.bmcl.2021.128257

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03372, KAKENHI-PROJECT-20H02855, KAKENHI-PROJECT-21K05123, KAKENHI-PROJECT-21K19038
  • [Journal Article] Analysis of GTP addition in the reverse (3′-5′) direction by human tRNA(His) guanylyltransferase2021

    • Author(s)
      Nakamura Akiyoshi、Wang Daole、Komatsu Yasuo
    • Journal Title

      RNA

      Volume: 27 Issue: 6 Pages: 665-675

    • DOI

      10.1261/rna.078287.120

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03372, KAKENHI-PROJECT-19K06519
  • [Journal Article] Similar frequency and signature of untargeted substitutions induced by abasic site analog under reduced human APE1 conditions2021

    • Author(s)
      Suzuki Tetsuya、Katayama Yuri、Komatsu Yasuo、Kamiya Hiroyuki
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 46 Issue: 6 Pages: 283-288

    • DOI

      10.2131/jts.46.283

    • NAID

      130008046831

    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03372, KAKENHI-PROJECT-19H04278, KAKENHI-PROJECT-20K12181
  • [Journal Article] Similar frequency and signature of untargeted substitutions induced by abasic site analog under reduced human APE1 conditions2021

    • Author(s)
      T. Suzuki、Y. Katayama、Y. Komatsu、H. Kamiya
    • Journal Title

      J. Toxicol. Sci.

      Volume: 46

    • NAID

      130008046831

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H04278
  • [Journal Article] Stable duplex-linked antisense targeting miR-148a inhibits breast cancer cell proliferation2021

    • Author(s)
      Okumura Sho、Hirano Yu、Komatsu Yasuo
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 11467-11467

    • DOI

      10.1038/s41598-021-90972-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03372, KAKENHI-PROJECT-21K05123
  • [Journal Article] PCR-based approach for site-specific conjugation of long double-stranded DNA to a single-domain VHH antibody2020

    • Author(s)
      Akazawa-Ogawa Yoko、Komatsu Yasuo、Nakajima Yoshihiro、Kojima Naoshi、Hagihara Yoshihisa
    • Journal Title

      The Journal of Biochemistry

      Volume: - Issue: 1 Pages: 63-72

    • DOI

      10.1093/jb/mvaa029

    • NAID

      40022279169

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05106
  • [Journal Article] Inhibition of breast cancer cell proliferation with anti-microRNA oligonucleotides flanked by interstrand cross-linked duplexes2020

    • Author(s)
      Okumura Sho、Hirano Yu、Komatsu Yasuo
    • Journal Title

      Nucleosides, Nucleotides & Nucleic Acids

      Volume: 39 Issue: 1-3 Pages: 225-235

    • DOI

      10.1080/15257770.2019.1671595

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K05917, KAKENHI-PROJECT-16H05106
  • [Journal Article] Large deletions and untargeted substitutions induced by abasic site analog on leading versus lagging strand templates in human cells2019

    • Author(s)
      Suzuki Tetsuya、Katayama Yuri、Komatsu Yasuo、Kamiya Hiroyuki
    • Journal Title

      Mutagenesis

      Volume: 34 Pages: 421-429

    • DOI

      10.1093/mutage/gez034

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H04278, KAKENHI-PROJECT-17K12824, KAKENHI-PROJECT-16H05106
  • [Journal Article] Adsorptive Stripping Voltammetry for the Determination of Dissolved Oxygen Using a Mesoporous Pt Microelectrode2019

    • Author(s)
      Masiki Ikegami, Yu Hirano, Yasuhiro Mie, Yasuo Komatsu
    • Journal Title

      Journal of The Electrochemical Society

      Volume: 166 Issue: 6 Pages: B542-B546

    • DOI

      10.1149/2.0021908jes

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K05917, KAKENHI-PROJECT-16K08218, KAKENHI-PROJECT-16H05106
  • [Journal Article] Molecular mechanism of substrate recognition and specificity of tRNAHis guanylyltransferase during nucleotide addition in the 3′-5′ direction2018

    • Author(s)
      Nakamura Akiyoshi、Wang Daole、Komatsu Yasuo
    • Journal Title

      RNA

      Volume: 24 Issue: 11 Pages: 1583-1593

    • DOI

      10.1261/rna.067330.118

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K18511, KAKENHI-PROJECT-16H05106
  • [Journal Article] Synthesis and Application of Interstrand Cross-Linked Duplexes by Covalently Linking a Pair of Abasic Sites2018

    • Author(s)
      Hirano Yu、Kojima Naoshi、Komatsu Yasuo
    • Journal Title

      Current Protocols in Nucleic Acid Chemistry

      Volume: 75 Issue: 1

    • DOI

      10.1002/cpnc.63

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K05917, KAKENHI-PROJECT-16H05106
  • [Journal Article] Function Control of Anti-microRNA Oligonucleotides Using Interstrand Cross-Linked Duplexes2018

    • Author(s)
      Yasuhiro Mie, Yu Hirano, Keiko Kowata, Akiyoshi Nakamura, Mayu Yasunaga, Yoshihiro Nakajima, Yasuo Komatsu
    • Journal Title

      MOLECULAR THERAPY-NUCLEIC ACIDS

      Volume: 10 Pages: 64-74

    • DOI

      10.1016/j.omtn.2017.11.003

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08218, KAKENHI-PROJECT-17K05917, KAKENHI-PROJECT-16H05106, KAKENHI-PROJECT-16H03295
  • [Journal Article] Biochemical analysis of human tRNAHis guanylyltransferase in mitochondrial tRNAHis maturation2018

    • Author(s)
      Nakamura Akiyoshi、Wang Daole、Komatsu Yasuo
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 503 Issue: 3 Pages: 2015-2021

    • DOI

      10.1016/j.bbrc.2018.07.150

    • NAID

      120006718707

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K18511, KAKENHI-PROJECT-16H05106
  • [Journal Article] Analysis of large deletion mutations induced by abasic site analog in human cells2018

    • Author(s)
      Suzuki Tetsuya、Katayama Yuri、Komatsu Yasuo、Kamiya Hiroyuki
    • Journal Title

      Genes and Environment

      Volume: 40 Issue: 1 Pages: 24-31

    • DOI

      10.1186/s41021-018-0110-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H02956, KAKENHI-PROJECT-16H05106
  • [Journal Article] Comparison of DNA fragments as donor DNAs upon sequence conversion of cleaved target DNA2017

    • Author(s)
      Suzuki Tetsuya、Imada Takashi、Komatsu Yasuo、Kamiya Hiroyuki
    • Journal Title

      Nucleosides, Nucleotides and Nucleic Acids

      Volume: 36 Issue: 6 Pages: 428-434

    • DOI

      10.1080/15257770.2017.1310385

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05106, KAKENHI-PROJECT-16H02956
  • [Journal Article] Comparison of DNA fragments as donor DNAs upon sequence conversion of cleaved target DNA2017

    • Author(s)
      T. Suzuki, T. Imada, Y. Komatsu and H. Kamiya
    • Journal Title

      Nucleosides, Nucleotides, Nucleic Acids

      Volume: 36

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16H02956
  • [Journal Article] Bienzyme reactions on cross-linked DNA scaffolds for electrochemical analysis.2017

    • Author(s)
      Hirano, Y., Ikegami, M., Kowata, K. and Komatsu, Y.
    • Journal Title

      Bioelectrochemistry

      Volume: 113 Pages: 15-19

    • DOI

      10.1016/j.bioelechem.2016.08.005

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25293030, KAKENHI-PROJECT-25410162
  • [Journal Article] 分子構造制御による高活性なmiRNA阻害核酸の構築2017

    • Author(s)
      小松康雄
    • Journal Title

      BIO CLINICA

      Volume: 33 Pages: 58-60

    • Data Source
      KAKENHI-PROJECT-16H05106
  • [Journal Article] オリゴヌクレオチドの合成後の化学修飾2016

    • Author(s)
      小松康雄
    • Journal Title

      核酸医薬の創製と応用展開

      Volume: 1 Pages: 104-112

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293030
  • [Journal Article] Development of a 3’-amino linker with high conjugation activity and its application to covalently cross-link blunt ends of a duplex2016

    • Author(s)
      Keiko Kowata, Naoshi Kojima, Yasuo Komatsu
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 24 Issue: 9 Pages: 2108-2113

    • DOI

      10.1016/j.bmc.2016.03.039

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K14933, KAKENHI-PROJECT-25293030
  • [Journal Article] Fabrication and characterization of nanoporous gold on microelectrode.2016

    • Author(s)
      Ikegami, M., Hirano, Y., Mie, Y. and Komatsu, Y.
    • Journal Title

      J. Electroanalytical Chem.

      Volume: 783 Pages: 188-191

    • DOI

      10.1016/j.jelechem.2016.11.023

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293030, KAKENHI-PROJECT-25460055
  • [Journal Article] Nanoporous structure of gold electrode fabricated by anodization and its efficacy for direct electrochemistry of human cytochrome P450.2016

    • Author(s)
      Mie, Y., Ikegami, M. and Komatsu, Y.
    • Journal Title

      10.1246/cl.160164

      Volume: 45 Issue: 6 Pages: 640-642

    • DOI

      10.1246/cl.160164

    • NAID

      130005155033

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293030, KAKENHI-PROJECT-25460055
  • [Journal Article] Faithful PCR amplification of an unnatural base pair analog, ImNN:NaOO, with four hydrogen bonds.2015

    • Author(s)
      Tarashima, N., Komatsu, Y., Furukawa, K. and Minakawa, N.
    • Journal Title

      Chem. Eur. J.

      Volume: 21 Issue: 30 Pages: 10688-10695

    • DOI

      10.1002/chem.201501484

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25293030
  • [Journal Article] Environmentally Responsive and Bright Fluorescent Probes Possessing Dansyl-modified Oligonucleotides under Hybridization of DNA and RNA.2015

    • Author(s)
      Suzuki, Y. and Komatsu, Y.
    • Journal Title

      RNA Technologies

      Volume: -

    • Data Source
      KAKENHI-PROJECT-25293030
  • [Journal Article] Environmentally Responsive and Bright Fluorescent Probes Possessing Dansyl-modified Oligonucleotides under Hybridization of DNA and RNA.2015

    • Author(s)
      Suzuki, Y. and Komatsu, Y.
    • Journal Title

      RNA Technologies (Springer series)

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25620121
  • [Journal Article] p-Aminothiophenol modification on gold surface improves stability for electrochemically driven cytochrome P450 microsome activity.2014

    • Author(s)
      Mie, Y., Tateyama, E. and Komatsu, Y.
    • Journal Title

      Electrochim. Acta

      Volume: 115 Pages: 364-369

    • DOI

      10.1016/j.electacta.2013.10.170

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293030, KAKENHI-PROJECT-25460055, KAKENHI-PROJECT-25620121
  • [Journal Article] Analysis of beat fluctuations and oxygen consumption in cardiomyocytes by scanning electrochemical microscopy.2014

    • Author(s)
      Hirano, Y., Kodama, M., Shibuya, M., Maki, Y. and Komatsu, Y.
    • Journal Title

      Anal. Biochem.

      Volume: 447C Pages: 39-42

    • DOI

      10.1016/j.ab.2013.11.008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293030, KAKENHI-PROJECT-25410162, KAKENHI-PROJECT-25620121
  • [Journal Article] Direct Electrochemistry of Microsomal Human Flavin-containing Monooxygenases 1 and 3 on Naphthalenethiol Thin Films.2013

    • Author(s)
      Ikegami, M., Mie, Y., Hirano, Y. and Komatsu, Y.
    • Journal Title

      Ecs Electrochemistry Letters

      Volume: 2 Issue: 12 Pages: G5-G7

    • DOI

      10.1149/2.003312eel

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293030, KAKENHI-PROJECT-25410162, KAKENHI-PROJECT-25620121
  • [Journal Article] 合成オリゴヌクレオチドに対する機能性分子の部位特異的導入法2013

    • Author(s)
      小松 康雄
    • Journal Title

      Pharm Tech Japan

      Volume: 29 Pages: 85-90

    • Data Source
      KAKENHI-PROJECT-25620121
  • [Journal Article] Development of dansyl-modified oligonucleotide probes responding to structural changes in a duplex.2013

    • Author(s)
      Suzuki, Y., Kowata, K. and Komatsu, Y.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 23 Issue: 22 Pages: 6123-6126

    • DOI

      10.1016/j.bmcl.2013.09.017

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293030, KAKENHI-PROJECT-25620121
  • [Journal Article] 合成オリゴヌクレオチドに対する機能性分子の部位特異的導入法2013

    • Author(s)
      小松 康雄
    • Journal Title

      Pharm Tech Japan

      Volume: 29 Pages: 85-90

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293030
  • [Journal Article] Development of a scanning electrochemical microscopy-based micropipette and its application to analysis of topographic change of single-cell2013

    • Author(s)
      平野 悠
    • Journal Title

      bioelectrochemistry

      Volume: 92 Pages: 1-5

    • DOI

      10.1016/j.bioelechem.2013.01.004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23750095, KAKENHI-PROJECT-25293030, KAKENHI-PROJECT-25620121
  • [Journal Article] Interstrand cross-link of DNA by covalently linking a pair of abasic sites2012

    • Author(s)
      Ichikawa, K., Kojima, N., Hirano, Y., Takebayashi, T., Kowata, K. and Komatsu, Y
    • Journal Title

      Chem. Commun.(Camb)

      Volume: 48 Issue: 15 Pages: 2143-2145

    • DOI

      10.1039/c2cc16785a

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21510239, KAKENHI-PROJECT-23750095
  • [Journal Article] End-tether Structure of DNA Alters Electron-transfer Pathway of Redox-labeled Oligo-DNA Duplex at Electrode Surface2012

    • Author(s)
      Mie, Y., Kojima, N., Kowata, K. and Komatsu, Y
    • Journal Title

      Chemistry Letters

      Volume: 41 Issue: 1 Pages: 62-64

    • DOI

      10.1246/cl.2012.62

    • NAID

      130004426305

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21510239, KAKENHI-PROJECT-23790065
  • [Journal Article] Size-controlled fabrication of gold nanodome arrays and its application to enzyme electrodes2011

    • Author(s)
      Ikegami, M., Mie, Y., Hirano, Y., Suzuki, M. and Komatsu, Y
    • Journal Title

      Colloids and Surfaces A : Physicochemical and Engineering Aspects

      Volume: 384 Issue: 1-3 Pages: 388-392

    • DOI

      10.1016/j.colsurfa.2011.04.024

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21510239
  • [Journal Article] Hydroxylamine, Oxime and Hydroxamic Acid Derivatives of Nucleic Acids2010

    • Author(s)
      Kojima, N. and Komatsu, Y
    • Journal Title

      Hydroxylamines, Oximes and Hydroxamic Acids

      Volume: 2 Pages: 807-851

    • DOI

      10.1002/9780470682531.pat0514

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21510239
  • [Journal Article] Gold sputtered electrode surfaces enhance direct electron transfer reactions of human cytochrome P450s2010

    • Author(s)
      Mie, Y., Ikegami, M. and Komatsu, Y
    • Journal Title

      Electchem. Comm

      Volume: 12 Issue: 5 Pages: 680-683

    • DOI

      10.1016/j.elecom.2010.03.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21510239
  • [Journal Article] DNA, RNAの末端および内部に対する化学修飾法の開発2010

    • Author(s)
      小松康雄
    • Journal Title

      生化学

      Volume: 82 Pages: 1141-1145

    • NAID

      10027880294

    • URL

      http://wwwsoc.nii.ac.jp/jbiochem/magazine/82-12-10.pdf

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21510239
  • [Journal Article] Hydroxylamine, Oxime and Hydroxamic Acid Derivatives of Nucleic Acids.2010

    • Author(s)
      Kojima, N., Komatsu, Y.
    • Journal Title

      Hydroxylamines, Oximes and Hydroxamic Acids

      Volume: 2 Pages: 807-851

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21510239
  • [Journal Article] DNA,RNAの末端および内部に対する化学修飾法の開発2010

    • Author(s)
      小松康雄
    • Journal Title

      生化学

      Volume: 82 Pages: 1141-1145

    • NAID

      10027880294

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21510239
  • [Journal Article] 遺伝子解析にかかわる試薬の開発2010

    • Author(s)
      小松康雄、小島直
    • Journal Title

      Synthesiology

      Volume: 3 Pages: 223-230

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21510239
  • [Journal Article] Efficient synthesis of oligonucleotide conjugates on solid-support using an(aminoethoxycarbonyl) aminohexyl group for 5'-terminal modification2009

    • Author(s)
      Kojima, N., Takebayashi, T., Mikami, A., Ohtsuka, E. and Komatsu, Y
    • Journal Title

      Bioorg. Med. Chem. Lett

      Volume: 19 Issue: 8 Pages: 2144-2147

    • DOI

      10.1016/j.bmcl.2009.02.121

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21510239
  • [Journal Article] Efficient synthesis of oligonucleotide conjugates on solid-support using an (aminoethoxycarbonyl)aminohexyl group for 5'-terminal modification2009

    • Author(s)
      Kojima, N., Takebayashi, T., Mikami, A., Ohtsuka, E. and Komatsu, Y
    • Journal Title

      Bioorg. Med. Chem. Lett 19

      Pages: 2144-2147

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19510230
  • [Journal Article] Construction of highly reactive probes for abasic site detection by introduction of an aromatic and a guanidine residue into an aminooxy group2009

    • Author(s)
      Kojima, N., Takebayashi, T., Mikami, A., Ohtsuka, E. and Komatsu, Y
    • Journal Title

      J. Am. Chem. Soc

      Volume: 131 Issue: 37 Pages: 13208-13209

    • DOI

      10.1021/ja904767k

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21510239
  • [Journal Article] Novel amino linkers enablingefficient labeling and convenient purification of amino-modified oligonucleotides2008

    • Author(s)
      Komatsu, Y., Kojima, N., Sugino, M., Mikami, A., Nonaka, K., Fujinawa, Y., Sugimoto, T., Sato, K., Matsubara, K. and Ohtsuka, E
    • Journal Title

      Bioorg. Med. Chem 16

      Pages: 941-949

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19510230
  • [Journal Article] Construction of an aminooxy derivative for RNA and DNA labeling2008

    • Author(s)
      Komatsu, Y., Kojima, N., Takebayashi, T., Mikami, A., Sugino, M. and Ohtsuka,E
    • Journal Title

      Nucleic Acids Symp. Ser. (Oxf) 52

      Pages: 393-394

    • Data Source
      KAKENHI-PROJECT-19510230
  • [Journal Article] Comparison of the chemical properties of a novel amino-linker with various amino modifications2008

    • Author(s)
      Kojima, N., Takebayashi, T., Mikami, A., Sugino, M., Ohtsuka, E. and Komatsu,Y
    • Journal Title

      Nucleic Acids Symp. Ser. (Oxf) 52

      Pages: 463-464

    • Data Source
      KAKENHI-PROJECT-19510230
  • [Journal Article] Hypothermic preservation effect on mammalian cells of type III antifreeze proteins from notched-fin eelpout2008

    • Author(s)
      Hirano, Y., Nishimiya, Y., Matsumoto, S., Matsushita, M., Todo, S., Miura, A., Komatsu, Y. and Tsuda, S
    • Journal Title

      Cryobiology 57

      Pages: 46-51

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19510230
  • [Journal Article] Construction of an aminooxy derivative for RNA and DNA labeling2008

    • Author(s)
      Komatsu, Y.
    • Journal Title

      Nucleic Acids Symp Ser (Oxf) 52

      Pages: 393-384

    • Data Source
      KAKENHI-PROJECT-19510230
  • [Journal Article] Novel amino linkers enabling efficient labeling and convenient purificati on of amino-modified oligonucleotides2008

    • Author(s)
      Komatsu, Y.
    • Journal Title

      Bioorg.Med.Chem 16

      Pages: 941-949

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19510230
  • [Journal Article] Construction of time-lapse scanning electrochemical microscopy with temperature control and its application to evaluate the preservation effects of antifreeze proteins on living cells2008

    • Author(s)
      Hirano, Y., Nishimiya, Y., Kowata, K., Mizutani, F., Tsuda, S. and Komatsu, Y
    • Journal Title

      Anal. Chem 80

      Pages: 9349-9354

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19510230
  • [Journal Article] 共有結合型DNAチップの開発2007

    • Author(s)
      小松 康雄
    • Journal Title

      新しいDNAチップの科学と応用

      Pages: 41-52

    • Data Source
      KAKENHI-PROJECT-19510230
  • [Journal Article] Osteopontin small interfering RNA protects mice from fulminant hepatitis2007

    • Author(s)
      Saito, Y., Kon, S., Fujiwara, Y., Nakayama, Y., Kurotaki, D., Fukuda, N., Kimura, C., Kanayama, M., Ito, K., Diao, H., Matsui, Y., Komatsu, Y., Ohtsuka, E. and Uede, T
    • Journal Title

      Hum. Gene Ther 18

      Pages: 1205-1214

    • Data Source
      KAKENHI-PROJECT-19510230
  • [Journal Article] Enhanced reactivity of amino-modified oligonucleotides by inserting of aromatic residue.2006

    • Author(s)
      Komatsu, Y.
    • Journal Title

      Bioorg.Med.Chem.Lett. 16

      Pages: 5118-5121

    • Data Source
      KAKENHI-PROJECT-17510190
  • [Journal Article] 基板表面に固定化させるオリゴヌクレオチドの化学合成2005

    • Author(s)
      小松 康雄
    • Journal Title

      化学と生物 44・3

      Pages: 199-204

    • NAID

      10017248266

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17510190
  • [Journal Article] Regulation of ribozyme activity with short oligonucleotides.2004

    • Author(s)
      Komatsu, Y.
    • Journal Title

      Biological & Pharmaceutical Bulletin 27

      Pages: 457-462

    • NAID

      110003608786

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15310157
  • [Journal Article] Regulation of ribozyme cleavage by oligonucleotides.2004

    • Author(s)
      Komatsu, Y.
    • Journal Title

      Methods in Molecular Biology 252

      Pages: 165-178

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15310157
  • [Journal Article] Regulation of ribozyme cleavage by oligonucleotides.2004

    • Author(s)
      Komatsu, Y
    • Journal Title

      Methods in Molecular Biology 252

      Pages: 165-178

    • Data Source
      KAKENHI-PROJECT-15310157
  • [Journal Article] Regulation of ribozyme activity with short oligonucleotides.2004

    • Author(s)
      Komatsu, Y
    • Journal Title

      Biological & Pharmaceutical Bulletin 27・4

      Pages: 457-462

    • NAID

      110003608786

    • Data Source
      KAKENHI-PROJECT-15310157
  • [Journal Article] Synthesis and application of new amino modification analogues for functional oligonucleotide.2004

    • Author(s)
      Komatsu, Y.
    • Journal Title

      Nucleic Acids Symp. Ser. 48

      Pages: 21-22

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15310157
  • [Patent] ゾル-ゲル法で作製される無機多孔質体を用いた核酸合成用担体2016

    • Inventor(s)
      小松康雄、小島直、坂本和也、井上聡、南海浩一
    • Industrial Property Rights Holder
      小松康雄、小島直、坂本和也、井上聡、南海浩一
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-002834
    • Filing Date
      2016-01-08
    • Data Source
      KAKENHI-PROJECT-25293030
  • [Patent] 核酸架橋体、二本鎖核酸に標的分子を結合させるための化合物、二本鎖核酸に標的分子を結合させるための方法及び化合物2015

    • Inventor(s)
      小松康雄、小島直
    • Industrial Property Rights Holder
      小松康雄、小島直
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-122467
    • Filing Date
      2015-06-17
    • Data Source
      KAKENHI-PROJECT-25293030
  • [Patent] マイクロ電極の電極表面の処理方法、表面処理マイクロ電極の製造方法及び表面処理マイクロ電極2015

    • Inventor(s)
      池上真志樹、平野悠、小松康雄
    • Industrial Property Rights Holder
      池上真志樹、平野悠、小松康雄
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-093240
    • Filing Date
      2015-04-30
    • Data Source
      KAKENHI-PROJECT-25293030
  • [Patent] 核酸複合体、核酸ハイブリダイゼーションの形成方法、医薬組成物、核酸検出用プローブ及び相補鎖核酸複合体2014

    • Inventor(s)
      小松康雄、平野 悠、三重安弘
    • Industrial Property Rights Holder
      小松康雄、平野 悠、三重安弘
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-251847
    • Filing Date
      2014-12-12
    • Data Source
      KAKENHI-PROJECT-25293030
  • [Presentation] 安定化した2本鎖構造を有するアンチセンス核酸の細胞内動態2023

    • Author(s)
      平野 悠、小松 康雄
    • Organizer
      日本核酸医薬学会第8回年会
    • Data Source
      KAKENHI-PROJECT-20H03372
  • [Presentation] 生物プロセス研究部門におけるバイオものづくり研究2023

    • Author(s)
      小松 康雄
    • Organizer
      LS-BT講演会
    • Data Source
      KAKENHI-PROJECT-20H03372
  • [Presentation] 生物プロセス研究部門の研究概要2023

    • Author(s)
      小松康雄
    • Organizer
      産総研北海道センターシンポジウムin札幌
    • Data Source
      KAKENHI-PROJECT-20H03372
  • [Presentation] 2本鎖構造を利用したアンチセンス核酸の細胞内局在の制御2022

    • Author(s)
      平野 悠、小松 康雄
    • Organizer
      日本核酸医薬学会第7回年会
    • Data Source
      KAKENHI-PROJECT-20H03372
  • [Presentation] 地域イノベーション創出連携拠点形成に向けたバイオリソース解析プラットフォーム2022

    • Author(s)
      成廣 隆、菊池 義智、光田 展隆、玉木 秀幸、小松 康雄
    • Organizer
      第20回 産総研・産技連LS-BT合同研究発表会
    • Data Source
      KAKENHI-PROJECT-20H03372
  • [Presentation] 2本鎖構造を有するアンチセンス核酸の細胞内局在2021

    • Author(s)
      平野 悠、小松 康雄
    • Organizer
      日本核酸医薬学会第6回年会
    • Data Source
      KAKENHI-PROJECT-20H03372
  • [Presentation] ヒト由来tRNAHisグアニルトランスフェラーゼによる逆方向(3′-5′)の塩基付加反応の解析とRNA5’末端修飾への応用2021

    • Author(s)
      中村 彰良、汪 道楽、小松 康雄
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-20H03372
  • [Presentation] 核酸の効率的な化学修飾を可能にするリンカーの開発2021

    • Author(s)
      小島 直、小松 康雄
    • Organizer
      理研セミナー「核酸分析の最前線 2」
    • Data Source
      KAKENHI-PROJECT-20H03372
  • [Presentation] Nucleotide recognition mechanism of human tRNAHis guanylyltransferase and its application to RNA 5′-modification2020

    • Author(s)
      中村 彰良、汪 道楽、小松 康雄
    • Organizer
      第43回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-20H03372
  • [Presentation] ヒト由来tRNAHis guanylyltransferaseによるミトコンドリアtRNAHisの5′末端修飾反応の解析2019

    • Author(s)
      中村彰良、汪 道楽、小松康雄
    • Organizer
      第21回日本RNA学会
    • Data Source
      KAKENHI-PROJECT-16H05106
  • [Presentation] International Symposium on Nucleic Acids Chemistry 20192019

    • Author(s)
      平野 悠、千高佐知子、小松康雄
    • Organizer
      日本核酸化学会
    • Data Source
      KAKENHI-PROJECT-16H05106
  • [Presentation] クロスリンク2本鎖構造によるanti-miRNAオリゴの細胞内局在への影響2019

    • Author(s)
      平野 悠、扇谷仁希、千高佐知子、三重安弘、小松康雄
    • Organizer
      核酸医薬学会 第5回年会
    • Data Source
      KAKENHI-PROJECT-16H05106
  • [Presentation] 解離しない 2 本鎖核酸の作製と、アンチセンスへの応用2019

    • Author(s)
      小松康雄
    • Organizer
      関西バイオ医療研究会 第10回講演会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05106
  • [Presentation] The nucleotide recognition mechanism of human tRNAHis guanylyltransferase in 3′-5′ nucleotide addition reaction2019

    • Author(s)
      中村彰良、汪 道楽、小松康雄
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16H05106
  • [Presentation] Abasic siteによる欠失変異の誘発へのAPE1ノックダウンの影響2018

    • Author(s)
      片山友里,鈴木哲矢,小松康雄,紙谷浩之
    • Organizer
      第57回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会
    • Data Source
      KAKENHI-PROJECT-16H02956
  • [Presentation] ヒト細胞における脱塩塩基部位アナログによるlarge deletionの誘発2018

    • Author(s)
      鈴木哲矢,片山友里,小松康雄,紙谷浩之
    • Organizer
      日本環境変異原学会第47回大会
    • Data Source
      KAKENHI-PROJECT-16H02956
  • [Presentation] 走査型電気化学顕微鏡用の白金/金コンポジット微細構造電極の開発2018

    • Author(s)
      池上真志樹、平野 悠、三重安弘、小松康雄
    • Organizer
      第65回応用物理学会春季学術講演会
    • Data Source
      KAKENHI-PROJECT-16H05106
  • [Presentation] Large deletion mutations induced by abasic site analog in human cells2018

    • Author(s)
      H. Kamiya, Y. Katayama, T. Suzuki, and Y. Komatsu
    • Organizer
      The 45th International Symposium on Nucleic Acids Chemistry
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02956
  • [Presentation] クロスリンク2本鎖構造を有するanti-miRNAオリゴ核酸の細胞内動態2018

    • Author(s)
      平野 悠、扇谷仁希、三重安弘、小綿 恵子、小松 康雄
    • Organizer
      核酸医薬学会 第4回年会
    • Data Source
      KAKENHI-PROJECT-16H05106
  • [Presentation] 標的DNAに切断を導入する配列変換におけるdonor核酸の比較2017

    • Author(s)
      鈴木哲矢、今田貴士、小松康雄、紙谷浩之
    • Organizer
      日本ゲノム編集学会第2回大会
    • Data Source
      KAKENHI-PROJECT-16H05106
  • [Presentation] 標的DNAに切断を導入する配列変換におけるdonor核酸の比較.2017

    • Author(s)
      鈴木哲矢,今田貴士,小松康雄,紙谷浩之
    • Organizer
      日本ゲノム編集学会第2回大会
    • Data Source
      KAKENHI-PROJECT-16H02956
  • [Presentation] Large deletion mutations induced by an abasic site analogue in human cells.2017

    • Author(s)
      H. Kamiya, Y. Katayama, T. Suzuki, and Y. Komatsu
    • Organizer
      12th International Conference and 5th Asian Congress on Environmental Mutagens
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02956
  • [Presentation] アノード溶解によるナノポーラスゴールド形成の電極サイズ依存性2017

    • Author(s)
      池上真志樹、平野 悠、三重安弘、小松康雄
    • Organizer
      応用物理学会春季学術講演会
    • Data Source
      KAKENHI-PROJECT-16H05106
  • [Presentation] アノード溶解によるナノポーラスゴールド形成の電極サイズ依存性2017

    • Author(s)
      池上真志樹、平野 悠、三重安弘、小松康雄
    • Organizer
      第64回応用物理学会春季学術講演会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2017-03-14
    • Data Source
      KAKENHI-PROJECT-25293030
  • [Presentation] 3’-5’ 方向塩基伸長を触媒する tRNA 修飾酵素の基質特異性解析2017

    • Author(s)
      中村彰良、汪 道楽、小松康雄
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      東北大学川内北キャンパス(仙台市青葉区)
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-25293030
  • [Presentation] 架橋化構造を有するanti-miRNAオリゴによる神経膠芽腫細胞の増殖抑制効果2017

    • Author(s)
      三重安弘、平野 悠、小綿恵子、小松康雄
    • Organizer
      日本核酸医薬学会第3回年会
    • Data Source
      KAKENHI-PROJECT-16H05106
  • [Presentation] Construction of a bienzyme immobilizing microelectrode by cross-linked DNA scaffolds and its application to analysis of cellular metabolism.2017

    • Author(s)
      平野 悠、池上真志樹、小綿恵子、小松康雄
    • Organizer
      The 44th International Symposium on Nucleic Acids Chemistry 2017
    • Data Source
      KAKENHI-PROJECT-16H05106
  • [Presentation] ナノポーラス構造によるシトクロムP450反応の効率的な電気化学制御2017

    • Author(s)
      三重安弘、池上真志樹、小松康雄
    • Organizer
      2017年度生命科学系合同年次大会
    • Data Source
      KAKENHI-PROJECT-16H05106
  • [Presentation] Electrochemically-assisted enzyme reaction: low cost production and sensitive detection of pharmaceuticals.2016

    • Author(s)
      三重 安弘、池上 真志樹、小松 康雄
    • Organizer
      第15回 LS-BT合同研究発表会
    • Place of Presentation
      産業技術総合研究所、つくば市
    • Year and Date
      2016-02-02
    • Data Source
      KAKENHI-PROJECT-25293030
  • [Presentation] クロスリンク2本鎖を有する核酸のmiRNA阻害効果と構造の相関性2016

    • Author(s)
      小綿 恵子、三重 安弘、平野 悠、中村 彰良、安永 茉由、中島 芳浩、小松 康雄
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜、横浜市
    • Year and Date
      2016-03-28
    • Data Source
      KAKENHI-PROJECT-25293030
  • [Presentation] 走査型電気化学顕微鏡を用いた心筋細胞の拍動解析2016

    • Author(s)
      奥村 翔、平野 悠、小松康雄、牧与志幸
    • Organizer
      第25回日本バイオイメージング学会
    • Place of Presentation
      名古屋市立大学薬学部 宮田専治記念ホール(名古屋市瑞穂区)
    • Year and Date
      2016-09-04
    • Data Source
      KAKENHI-PROJECT-25293030
  • [Presentation] Structure-function relationship of anti-miRNA oligonucleotides modified with interstrand cross-links.2016

    • Author(s)
      三重安弘、小綿恵子、平野 悠、中村彰良、安永茉由、中島芳浩、小松康雄
    • Organizer
      The 21st Annual Meeting of the RNA Society
    • Place of Presentation
      国立京都国際会館(京都市左京区)
    • Year and Date
      2016-06-28
    • Data Source
      KAKENHI-PROJECT-25293030
  • [Presentation] 核酸の新規安定化技術の開発と、遺伝子分析ならびに医薬品への応用2016

    • Author(s)
      小松康雄
    • Organizer
      新技術説明会
    • Place of Presentation
      JST東京本部別館ホール(東京都千代田区)
    • Data Source
      KAKENHI-PROJECT-25293030
  • [Presentation] クロスリンク2本鎖構造を有する anti-miRNA オリゴ核酸の構造と miRNA 阻害活性との相関2016

    • Author(s)
      三重安弘、平野 悠、小綿恵子、中村彰良、安永茉由、中島芳浩、小松康雄
    • Organizer
      日本核酸医薬学会第2回年会
    • Place of Presentation
      東京理科大学葛飾キャンパス(東京都葛飾区)
    • Year and Date
      2016-11-15
    • Data Source
      KAKENHI-PROJECT-25293030
  • [Presentation] 走査型電気化学顕微鏡を基盤とした心筋細胞解析システムの開発2016

    • Author(s)
      奥村 翔、平野 悠、小松康雄、牧与志幸
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-25293030
  • [Presentation] Interstrand cross-link of 2′-O-Methyl RNA duplexes and its application as miRNA inhibitors.2015

    • Author(s)
      三重 安弘、平野 悠、小綿 恵子、中村 彰良、安永 茉由、中島 芳浩、小松 康雄
    • Organizer
      日本核酸医薬学会第1回年会
    • Place of Presentation
      京都テルサ、京都市
    • Year and Date
      2015-11-30
    • Data Source
      KAKENHI-PROJECT-25293030
  • [Presentation] 2′-O-Methyl RNA 2本鎖の分子内架橋化反応とmiRNA阻害核酸への展開2015

    • Author(s)
      三重 安弘、平野 悠、小綿 恵子、小松 康雄
    • Organizer
      第17 回日本RNA 学会年会
    • Place of Presentation
      ホテルライフォート札幌、札幌市
    • Year and Date
      2015-07-15
    • Data Source
      KAKENHI-PROJECT-25293030
  • [Presentation] Electrochemical Analysis of P450s in Microfluidic Channel.2015

    • Author(s)
      三重 安弘、小松 康雄
    • Organizer
      日本生物物理学会
    • Place of Presentation
      金沢大学、金沢市
    • Year and Date
      2015-09-16
    • Data Source
      KAKENHI-PROJECT-25293030
  • [Presentation] P450電気化学触媒の基盤技術2014

    • Author(s)
      三重 安弘、池上 真志樹、小松 康雄
    • Organizer
      北大ー産総研合同シンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2014-08-29
    • Data Source
      KAKENHI-PROJECT-25293030
  • [Presentation] P450電気化学触媒の基盤技術2014

    • Author(s)
      三重 安弘、池上 真志樹、小松 康雄
    • Organizer
      北大ー産総研合同シンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2014-08-29
    • Data Source
      KAKENHI-PROJECT-25620121
  • [Presentation] Environmentally Responsive and Bright Fluorescent Probes Possessing Dansyl-modified Oligonucleotides under Hybridization of DNA and RNA.2014

    • Author(s)
      鈴木 祥夫、小綿 恵子、小松 康雄
    • Organizer
      Biosensors2014
    • Place of Presentation
      オーストラリア
    • Year and Date
      2014-05-28
    • Data Source
      KAKENHI-PROJECT-25293030
  • [Presentation] Environmentally Responsive and Bright Fluorescent Probes Possessing Dansyl-modified Oligonucleotides under Hybridization of DNA and RNA.2014

    • Author(s)
      鈴木 祥夫、小綿 恵子、小松 康雄
    • Organizer
      Biosensors2014
    • Place of Presentation
      オーストラリア
    • Year and Date
      2014-05-28
    • Data Source
      KAKENHI-PROJECT-25620121
  • [Presentation] 合成核酸からの分析化学へのアプローチ2014

    • Author(s)
      小松 康雄
    • Organizer
      日本分析化学会第63年会
    • Place of Presentation
      広島大学
    • Year and Date
      2014-09-18
    • Invited
    • Data Source
      KAKENHI-PROJECT-25293030
  • [Presentation] 合成核酸からの分析化学へのアプローチ2014

    • Author(s)
      小松 康雄
    • Organizer
      日本分析化学会第63年会
    • Place of Presentation
      広島大学
    • Year and Date
      2014-09-18
    • Invited
    • Data Source
      KAKENHI-PROJECT-25620121
  • [Presentation] 核酸中のアルデヒド基に反応する試薬の開発と応用2011

    • Author(s)
      小松康雄
    • Organizer
      核酸・核タンパク機能性研究会学術集会
    • Place of Presentation
      恵庭リサ-チ・ビジネスパ-ク(北海道)
    • Year and Date
      2011-08-08
    • Data Source
      KAKENHI-PROJECT-21510239
  • [Presentation] 核酸の活用技術の開発2011

    • Author(s)
      小松康雄
    • Organizer
      大通りサテライトセミナー
    • Place of Presentation
      R&Bパーク札幌大通サテライト(北海道)
    • Year and Date
      2011-04-26
    • Data Source
      KAKENHI-PROJECT-21510239
  • [Presentation] Effect of End-tether Structure of Redox-DNA on its Electron Transfer Pathway at Electrode Surface2011

    • Author(s)
      三重安弘、小島直、小綿恵子、小松康雄
    • Organizer
      第38回国際核酸化学シンポジウム
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2011-11-10
    • Data Source
      KAKENHI-PROJECT-21510239
  • [Presentation] Electrochemical monitoring of enzyme reactions promoted on double stranded DNA2011

    • Author(s)
      平野悠、市川康平、小島直、小松康雄
    • Organizer
      第38回国際核酸化学シンポジウム
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2011-11-10
    • Data Source
      KAKENHI-PROJECT-21510239
  • [Presentation] 核酸の活用技術の開発2011

    • Author(s)
      小松康雄
    • Organizer
      大通りサテライトセミナー
    • Place of Presentation
      R & Bパーク札幌大通サテライト(北海道)
    • Year and Date
      2011-04-26
    • Data Source
      KAKENHI-PROJECT-21510239
  • [Presentation] 核酸中のアルデヒド基に反応する試薬の開発と応用2011

    • Author(s)
      小松康雄
    • Organizer
      核酸・核タンパク機能性研究会学術集会
    • Place of Presentation
      恵庭リサーチ・ビジネスパーク(北海道)
    • Year and Date
      2011-08-08
    • Data Source
      KAKENHI-PROJECT-21510239
  • [Presentation] 2本鎖構造の安定化を目的とした架橋化試薬の開発2010

    • Author(s)
      小松康雄
    • Organizer
      第20回アンチセンスシンポジウム
    • Place of Presentation
      甲南大学(神戸)
    • Year and Date
      2010-12-03
    • Data Source
      KAKENHI-PROJECT-21510239
  • [Presentation] 遺伝子解析に活用する試薬の開発2010

    • Author(s)
      小松康雄
    • Organizer
      日本化学会第90年会
    • Place of Presentation
      近畿大学(大阪府)
    • Year and Date
      2010-03-27
    • Data Source
      KAKENHI-PROJECT-21510239
  • [Presentation] 核酸の利用技術2010

    • Author(s)
      小松康雄
    • Organizer
      産総研本格研究ワークショップ
    • Place of Presentation
      全日空ホテル(札幌)
    • Year and Date
      2010-07-14
    • Data Source
      KAKENHI-PROJECT-21510239
  • [Presentation] 遺伝子解析に用いる試薬の開発2010

    • Author(s)
      小松康雄
    • Organizer
      バイオチップコンソーシアム
    • Place of Presentation
      新宿(東京都)
    • Year and Date
      2010-02-23
    • Data Source
      KAKENHI-PROJECT-21510239
  • [Presentation] 核酸の利用技術2010

    • Author(s)
      小松康雄
    • Organizer
      産総研本格研究ワークショップ
    • Place of Presentation
      全日空ホテル(北海道)
    • Year and Date
      2010-07-14
    • Data Source
      KAKENHI-PROJECT-21510239
  • [Presentation] Recent research on chemical reagents used for genetic analyses.2009

    • Author(s)
      小松康雄
    • Organizer
      Franco-Japanese Workshop in Life Sciences
    • Place of Presentation
      CNRS(パリ)
    • Year and Date
      2009-09-22
    • Data Source
      KAKENHI-PROJECT-21510239
  • [Presentation] Recent research on chemical reagents used for genetic analyses2009

    • Author(s)
      小松康雄
    • Organizer
      Franco-Japanese Workshop in Life Sciences
    • Place of Presentation
      CNRS(パリ)
    • Year and Date
      2009-09-22
    • Data Source
      KAKENHI-PROJECT-21510239
  • [Presentation] Development of novel chemical probes to detect abasic sites in DNA2009

    • Author(s)
      小島直、竹林知志恵、三上暁子、大塚榮子、小松康雄
    • Organizer
      第6回国際核酸化学シンポジウム
    • Place of Presentation
      高山(岐阜県)
    • Year and Date
      2009-09-29
    • Data Source
      KAKENHI-PROJECT-21510239
  • [Presentation] アルデヒド含有核酸を検出する試薬の開発2009

    • Author(s)
      小松康雄
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2009-03-27
    • Data Source
      KAKENHI-PROJECT-19510230
  • [Presentation] Construction of an aminooxy derivative for RNA and DNA labeling2008

    • Author(s)
      小松康雄
    • Organizer
      Joint Symposium of the 18thInternational Roundtable on Nucleosides, Nucleotides and Nucleic Acids and the 35th Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      京都大学
    • Year and Date
      2008-09-11
    • Data Source
      KAKENHI-PROJECT-19510230
  • [Presentation] Construction of an aminooxy derivative for RNA and DNA labeling2008

    • Author(s)
      小松康雄
    • Organizer
      Joint Symposium of the 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and the 35th Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      京都大学
    • Year and Date
      2008-09-11
    • Data Source
      KAKENHI-PROJECT-19510230
  • [Presentation] 2本鎖間架橋化DNAを活用した電極界面上での酵素反応場の構築

    • Author(s)
      平野 悠, 小玉 実生恵, 小綿 恵子, 池上 真志樹, 小松 康雄
    • Organizer
      薬学会第134年会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-25620121
  • [Presentation] 査型電気化学顕微鏡を利用した心筋細胞の拍動解析技術の開発

    • Author(s)
      平野 悠, 小玉 実生恵, 牧 与志幸, 渋谷真広, 小松 康雄
    • Organizer
      日本分析化学会第62年会
    • Place of Presentation
      近畿大学
    • Data Source
      KAKENHI-PROJECT-25293030
  • [Presentation] 査型電気化学顕微鏡を利用した心筋細胞の拍動解析技術の開発

    • Author(s)
      平野 悠, 小玉 実生恵, 牧 与志幸, 渋谷真広, 小松 康雄
    • Organizer
      日本分析化学会第62年会
    • Place of Presentation
      近畿大学
    • Data Source
      KAKENHI-PROJECT-25620121
  • [Presentation] Fluorescent “on-off” Swit ching under Hybridization of DNA and RNA with Dansyl-modified Oligonucleotides.

    • Author(s)
      鈴木 祥夫, 小綿 恵子, 小松 康雄
    • Organizer
      第40回 国際核酸化学シンポジウム
    • Place of Presentation
      神奈川大学
    • Data Source
      KAKENHI-PROJECT-25293030
  • [Presentation] Fluorescent “on-off” Switching under Hybridization of DNA and RNA with Dansyl-modified Oligonucleotides.

    • Author(s)
      鈴木 祥夫, 小綿 恵子, 小松 康雄
    • Organizer
      第40回 国際核酸化学シンポジウム
    • Place of Presentation
      神奈川大学
    • Data Source
      KAKENHI-PROJECT-25620121
  • [Presentation] 2本鎖間架橋化DNAを活用した電極界面上での酵素反応場の構築

    • Author(s)
      平野 悠, 小玉 実生恵, 小綿 恵子, 池上 真志樹, 小松 康雄
    • Organizer
      薬学会第134年会
    • Place of Presentation
      熊本大学
    • Data Source
      KAKENHI-PROJECT-25293030
  • 1.  Shuto Satoshi (70241346)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 2.  平野 悠 (70415735)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 31 results
  • 3.  INOUE Hideo (80088856)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  大塚 栄子 (80028836)
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  • 5.  KAMIYA Hiroyuki (10204629)
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    # of Collaborated Products: 9 results
  • 6.  鈴木 哲矢 (20573950)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  MATSUNAGA Tsukasa (60192340)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  MORIOKA Hiroshi (20230097)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  INOUE Tan (40114855)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  SHIRAISHI Hideaki (90202118)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  TANI Tokio (80197516)
    # of Collaborated Projects: 1 results
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  • 12.  TAIRA Kazunari (10261778)
    # of Collaborated Projects: 1 results
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  • 13.  SAKAMOTO Kensaku (50240685)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  SUZUKI Tsutomu (20292782)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  KOJIMA Naoshi (30356985)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 16.  UEDE Toshimitsu (00160185)
    # of Collaborated Projects: 1 results
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  • 17.  KON Shigeyuki (90344499)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  南川 典昭 (40209820)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 19.  二階堂 修 (60019669)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  新田 至 (30272404)
    # of Collaborated Projects: 1 results
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  • 21.  福田 隼 (30434450)
    # of Collaborated Projects: 1 results
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  • 22.  有澤 光弘 (40312962)
    # of Collaborated Projects: 1 results
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  • 23.  山口 浩明 (80400373)
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  • 24.  一ノ瀬 亘 (00636409)
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  • 25.  渡邉 瑞貴 (20507173)
    # of Collaborated Projects: 1 results
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  • 26.  藤原 広一 (40837853)
    # of Collaborated Projects: 1 results
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  • 27.  後藤 佑樹 (70570604)
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  • 28.  河合 秀彦 (30379846)
    # of Collaborated Projects: 1 results
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  • 29.  STEWART Jon D.
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  • 30.  BENKOVIC Stephen J.
    # of Collaborated Projects: 1 results
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  • 31.  SAJI Tetsuya
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 10 results
  • 32.  NAKAMURA Akiyoshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 33.  三重 安弘
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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