Imai Yuzuru 今居譲

… Alternative Names

IMAI Yuzuru 今居譲

今居讓イマイユズル

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Researcher Number	30321730
Other IDs	https://orcid.org/0000-0003-2924-5231
External Links
Affiliation (Current)	2025: 順天堂大学, 大学院医学研究科, 先任准教授
Affiliation (based on the past Project Information) *help	2024: 順天堂大学, 大学院医学研究科, 先任准教授 2021 – 2022: 順天堂大学, 大学院医学研究科, 先任准教授 2016 – 2020: 順天堂大学, 医学(系)研究科(研究院), 先任准教授 2017: 順天堂大学, 医学研究科, 先任准教授 2017: 順天堂大学, 医学部, 准教授 … More 2014 – 2016: 順天堂大学, 医学(系)研究科(研究院), 准教授 2014: 順天堂大学, 医学研究科, 先任准教授 2011 – 2012: 順天堂大学, 医学(系)研究科(研究院), 准教授 2011 – 2012: 順天堂大学, 大学院・医学研究科, 先任准教授 2011: 順天堂大学, 医学部, 准教授 2010: 順天堂大学, 医学研究科, 先任准教授 2009: Tohoku University, 加齢医学研究所, 准教授 2005: 理研, 研究員 2004: RIKEN, Lab Motor System Neurodegeneration, Special Postdoctoral Researcher, 運動神経変性研究チーム, 基礎科学特別研究員 2004: 独立行政法人理化学研究所, 運動系神経変性研究チーム, 研究員 2003: 独立行政法人理化学研究所, 運動系神経変性研究チーム, 基礎科学特別研究員 2001 – 2002: 理化学研究所, 運動系神経変性研究チーム, 基礎科学特別研究員 Less
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Basic Section 49010:Pathological biochemistry-related / Neurology / Biological Sciences / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Nerve anatomy/Neuropathology / Neurochemistry/Neuropharmacology Except Principal Investigator Neurology / Neurology / Applied entomology
Keywords	Principal Investigator パーキンソン病 / ショウジョウバエ / ミトコンドリア / 神経変性疾患 / Parkin / ドーパミン神経 / PINK1 / キナーゼ / ユビキチンリガーゼ / iPS … More / iPS細胞 / リン酸化 / 神経変性 / ドパミン神経 / ユビキチン / 脂質 / α-Synuclein / リン脂質 / αシヌクレイン / 創薬 / シグナル伝達 / CHCHD2 / 脳神経疾患 / LRRK2 / 小胞体関連分解 / ユビキチン-プロテアソーム / ELOVL7 / PLA2G6 / 脂質解析 / リソソーム / 伝搬 / Drosophila / alpha-synuclein / タンパク質凝集 / セロトニン神経 / プリオン病 / 消化管 / 炎症 / カルシウム / 光遺伝学 / カルシウムチャネル / カルシウムイメージング / alpha-Synuclein / メンブレンダイナミクス / 創薬探索 / シナプス小胞 / 神経シナプス / 酵素 / スクリーニング / 遺伝学 / 酸化ストレス / マイトファジー / 神経軸索輸送 / Miro / Notchシグナル / エンドソーム / 神経軸索 / GTPase / 小胞輸送 / Lewy body / Pael-R / パーキン / 黒質-線条体 / パエル受容体 / ドーパミン / プロテアソーム / 神経細胞死 / 小胞体ストレス / 分子シャペロン / CHIP … More Except Principal Investigator パーキンソン病 / Pael-R / Parkin / ショウジョウバエ / 遺伝性パーキンソン病 / mitophagy / マイトファジー / PINK1 / PLA2G6 / オートファジー / 封入体 / 脂質代謝 / GBA / CHCHD2 / ATP13A2 / リソソーム / ミトコンドリア / AMPA receptor / caspase / transgenic mouse / mutant SOD1 / ER stress / parkin / Parkinson disease / Hsp70 / CHIP / ERAD / 小胞体ストレス / Glup / ユビキチンリガーゼ / AR-AP / IAP / HtrA2 / パエル受容体 / レビー小体 / AR-JP / AMPA受容体 / カスパーゼ / トランスジェニックマウス / 変異S0D1 / ERストレス / Peal-R / 神経活動記録法 / 嗅覚情報処理機構 / フェロモン / 生体イメージング / 嗅覚 / 性フェロモン Less

Elucidation of the mechanism of alpha-Synuclein aggregation by lipid and mitochondrial alterationPrincipal Investigator
- Principal Investigator
  
  今居譲
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Juntendo University
Analysis of propagation risk factors for food-derived alpha-Synuclein seedsPrincipal Investigator
- Principal Investigator
  
  Imai Yuzuru
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Juntendo University
Elucidation of intracellular environmental factors that produce a risk for alpha-Synuclein seedingPrincipal Investigator
- Principal Investigator
  
  Imai Yuzuru
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Juntendo University
Exploration of Parkinson disease-specific pathological backgroundPrincipal Investigator
- Principal Investigator
  
  IMAI Yuzuru
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Juntendo University
Drug screening to improve mitochondrial functionsPrincipal Investigator
- Principal Investigator
  
  Imai Yuzuru
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
Analysis of lipid composition in hereditary Parkinson's Disease and the association with the pathology
- Principal Investigator
  
  Hattori Nobutaka
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
ミトコンドリアの共生を規定する、排除と維持の監視メカニズムの解明Principal Investigator
- Principal Investigator
  
  今居譲
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Juntendo University
A study on the common pathogenesis of Parkinson's disease as a mitochondrial diseasePrincipal Investigator
- Principal Investigator
  
  Imai Yuzuru
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Juntendo University
Elucidation of the mechanism of mitochondrial maintenance by Parkinson's disease gene products
- Principal Investigator
  
  SHIBA Kahori
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
in vivo live imaging for sex pheromone information presentation neural mechanism in Drosophila olfaction
- Principal Investigator
  
  INOSHITA Tsuyoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied entomology
- Research Institution
  Juntendo University
  Kyoto University
晩発性パーキンソン病原因遺伝子産物タンパク質ネットワークの包括的解析Principal Investigator
- Principal Investigator
  
  今居譲
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Juntendo University
Analysis of the molecular mechanism by which the genes for early‐onset parkinson's disease regulate mitochondrial maintenancePrincipal Investigator
- Principal Investigator
  
  IMAI Yuzuru
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
Development of a multiphase screening method for genes responsible for age-dependent neurodegenerative disordersPrincipal Investigator
- Principal Investigator
  
  IMAI Yuzuru
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Juntendo University
  Tohoku University
常染色体劣性若年性パーキンソニズムの原因遺伝子産物Parkinの機能解析Principal Investigator
- Principal Investigator
  
  今居譲
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  The Institute of Physical and Chemical Research
The molecular mechanisms underlying neurodegeneration
- Principal Investigator
  
  TAKAHASHI Ryosuke
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  The Institute of Physical and Chemical Research
常染色体劣性若年性パーキンソニズムの原因遺伝子産物Parkinの機能解析Principal Investigator
- Principal Investigator
  
  今居譲
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  The Institute of Physical and Chemical Research

[Book] Experimental Models of Parkinson’s Disease.2021
- Author(s)
  Imai Y
- Total Pages
  228
- Publisher
  Humana Press
- Data Source
  KAKENHI-PROJECT-20K21531
[Book] Experimental Models of Parkinson’s Disease2021
- Author(s)
  Yuzuru Imai
- Total Pages
  228
- Publisher
  Humana Press
- Data Source
  KAKENHI-PROJECT-20H03453
[Book] 認知症　発症前治療のために解明すべき分子病態は何か？ -劣性遺伝性若年性パーキンソン病(AR-JP)の臨床、病理、分子遺伝学2017
- Author(s)
  服部信孝、今居　譲、柴佳保里
- Total Pages
  252
- Publisher
  羊土社
- ISBN
  9784758103640
- Data Source
  KAKENHI-PROJECT-17H04049
[Book] 遺伝子から探るパーキンソン病病態へのミトコンドリアの関与2017
- Author(s)
  今居　譲、柴佳保里、服部信孝
- Total Pages
  127
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-16K15484
[Book] 週刊　医学のあゆみ　ミトコンドリア研究 UPDATE2017
- Author(s)
  今居　譲、柴佳保里、服部信孝
- Total Pages
  127
- Publisher
  医歯薬出版
- ISBN
  4910204710178
- Data Source
  KAKENHI-PROJECT-17H04049
[Book] 遺伝子から探るバーキンソン病病態へのミトコンドリアの関与、ミ卜コンドリア研究 UPDATE、医学のあゆみ2017
- Author(s)
  今居　譲、柴佳保里、服部信孝
- Total Pages
  1030
- Publisher
  医歯薬出版株式会社、東京
- Data Source
  KAKENHI-PROJECT-15H04842
[Book] 別冊　医学のあゆみ　ミトコンドリア研究 UPDATE2017
- Author(s)
  今居　譲、柴佳保里、服部信孝
- Total Pages
  128
- Publisher
  医歯薬出版
- ISBN
  4910204761071
- Data Source
  KAKENHI-PROJECT-17H04049
[Book] Nova Biomedical.2017
- Author(s)
  Inoshita T, Imai Y
- Total Pages
  225
- Publisher
  Horizons in Neuroscience Research
- Data Source
  KAKENHI-PROJECT-26293070
[Book] 日本臨牀2017
- Author(s)
  今居　譲
- Total Pages
  156
- Publisher
  パーキンソン病-基礎・臨床の最新情報-
- Data Source
  KAKENHI-PROJECT-17H04049
[Book] 遺伝子から探るバーキンソン病病態へのミトコンドリアの関与、ミ卜コンドリア研究 UPDATE、医学のあゆみ2017
- Author(s)
  今居　譲、柴佳保里、服部信孝．
- Publisher
  医歯薬出版株式会社、東京
- Data Source
  KAKENHI-PROJECT-15H04842
[Book] パーキンソン病 -基礎・臨床の最新情報- ミトコンドリア機能障害とパーキンソン病2017
- Author(s)
  今居　譲
- Total Pages
  168
- Publisher
  日本臨床社
- ISBN
  4910069150171
- Data Source
  KAKENHI-PROJECT-26293070
[Book] ミトコンドリア機能障害とパーキンソン病2017
- Author(s)
  今居　譲
- Total Pages
  168
- Publisher
  日本臨牀
- Data Source
  KAKENHI-PROJECT-16K15484
[Book] Methods Mol Biol.2017
- Author(s)
  Imai Y, Inoshita T, Shiba-Fukushima K, Meng H, Hattori N
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-26293070
[Book] 実験医学2015
- Author(s)
  今居　譲、柴佳保里、服部信孝
- Total Pages
  134
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-26461280
[Book] Cell Death - Autophagy, Necrosis and Apoptosis2015
- Author(s)
  Arano T, Imai Y
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-26293070
[Book] 実験医学2015
- Author(s)
  今居　譲、柴佳保里、服部信孝
- Publisher
  羊土社
- Data Source
  KAKENHI-PUBLICLY-26117727
[Book] Cell Death - Autophagy, Necrosis and Apoptosis2015
- Author(s)
  Arano T, Imai Y
- Total Pages
  434
- Publisher
  InTech
- Data Source
  KAKENHI-PUBLICLY-26117727
[Book] 実験医学2015
- Author(s)
  今居　譲
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-26293070
[Book] AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging2013
- Author(s)
  Yuzuru Imai
- Publisher
  Elsevier Publishing Company
- Data Source
  KAKENHI-PROJECT-23790973
[Book] シリーズアクチュアル脳・神経疾患の臨床, パーキンソン病とMovement Disorders2013
- Author(s)
  今居　譲
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-23790973
[Book] 「ミトコンドリア病としてのパーキンソン病」脳212013
- Author(s)
  澤田知世、今居譲、高橋良輔
- Data Source
  KAKENHI-PROJECT-23790973
[Book] シリーズアクチュアル脳・神経疾患の臨床, パーキンソン病とMovement Disorders2013
- Author(s)
  今居　譲
- Publisher
  パーキンソン病の病態機序
- Data Source
  KAKENHI-PUBLICLY-23110502
[Book] 臨床・創薬利用がみえてきたmicroRNA2012
- Author(s)
  今居譲
- Publisher
  メディカルドゥ(印刷中)
- Data Source
  KAKENHI-PUBLICLY-23110502
[Book] Current Topics「PINK1とParkinはミトコンドリアの神経軸索輸送を制御する」2012
- Author(s)
  澤田知世、高橋良輔、Bingwei Lu、今居譲
- Publisher
  実験医学
- Data Source
  KAKENHI-PROJECT-23790973
[Book] 加齢と神経変性疾患遺伝性パーキンソン病原因遺伝子の機能解析から明らかとなってきたミトコンドリアの品質管理機構2011
- Author(s)
  今居　譲
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-23790973
[Book] 遺伝性パーキンソン病発症の分子基盤2011
- Author(s)
  今居譲
- Publisher
  クバプロ(印刷中)
- Data Source
  KAKENHI-PROJECT-21790302
[Book] ブレインサイエンス・レビュー遺伝性パーキンソン病発症の分子基盤2011
- Author(s)
  今居譲
- Publisher
  クバプロ
- Data Source
  KAKENHI-PUBLICLY-23110502
[Book] 「遺伝の分子基盤」ブレインサイエンス・レビュー2011
- Author(s)
  今居譲
- Publisher
  クバプロ社
- Data Source
  KAKENHI-PROJECT-21790302
[Book] 加齢と神経変性疾患遺伝性パーキンソン病原因遺伝子の機能解析から明らかとなってきたミトコンドリアの品質管理機構2011
- Author(s)
  今居譲
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PUBLICLY-23110502
[Book] 加齢と神経変性疾患:遺伝性パーキンソン病原因遺伝子の機能解析から明らかとなってきたミトコンドリアの品質管理機構2011
- Author(s)
  今居譲、斉木臣二、服部信孝
- Publisher
  アンチ・エイジング医学
- Data Source
  KAKENHI-PROJECT-23790973
[Book] The HECT-Type Ubiquitin Ligase Huwe1 Mediates the Stability of PINK1.2011
- Author(s)
  Sawada T, Kanao T, Kobayashi Y, Takahashi R, Imai Y
- Publisher
  J Mov Disord
- Data Source
  KAKENHI-PROJECT-23790973
[Book] ブレインサイエンス・レビュー遺伝性パーキンソン病発症の分子基盤2011
- Author(s)
  今居　譲
- Publisher
  クバプロ
- Data Source
  KAKENHI-PROJECT-23790973
[Book] 実験医学増刊号:遺伝性パーキンソン病原因遺伝子研究の新展開2010
- Author(s)
  今居譲
- Total Pages
  7
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-21790302
[Book] パーキンソン病原因遺伝子研究の進展2010
- Author(s)
  今居譲
- Publisher
  最新医学社(印刷中)
- Data Source
  KAKENHI-PROJECT-21790302
[Book] 「パーキンソン病原因遺伝子研究の進展」最新医学第65巻4号2010
- Author(s)
  今居譲
- Data Source
  KAKENHI-PROJECT-21790302
[Book] 「遺伝性パーキンソン病原因遺伝子研究の新展開」実験医学増刊号第28巻5号2010
- Author(s)
  今居譲
- Data Source
  KAKENHI-PROJECT-21790302
[Book] Brain and Nerve : 遺伝性パーキンソン病研究の最前線2010
- Author(s)
  今居譲
- Total Pages
  11
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-21790302
[Book] 「遺伝性パーキンソン病研究の最前線:分子標的治療にむけて」Brain and Nerve 第61巻8号2009
- Author(s)
  今居譲, 高橋良輔
- Data Source
  KAKENHI-PROJECT-21790302
[Book] Mitophagy Controlled by the PINK1-Parkin Pathway is Associated with Parkinson's Disease Pathogenesis. In: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, and Infection, Hayat MA ed, Elsevier, Amsterdam, in press
- Author(s)
  Imai Y, Hattori N
- Publisher
  (in press)
- Data Source
  KAKENHI-PROJECT-23790973
[Book] 「パーキンソン病の病態機序」シリーズアクチュアル脳・神経疾患の臨床, パーキンソン病とMovement Disorders
- Author(s)
  今居譲
- Publisher
  (印刷中)
- Data Source
  KAKENHI-PROJECT-23790973
[Book] Parkin and stress. In Molecular Mechanisms in Parkinson's disease,
- Author(s)
  Imai, Y., Takahashi, R.
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207032
[Journal Article] Is Glial Dysfunction the Key Pathogenesis of LRRK2-Linked Parkinson’s Disease?2023
- Author(s)
  Iseki Tatou、Imai Yuzuru、Hattori Nobutaka
- Journal Title
  
  Biomolecules
  
  Volume: 13 Issue: 1 Pages: 178-178
- DOI
  10.3390/biom13010178
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21531
[Journal Article] Ubiquitination at the lysine 27 residue of the Parkin ubiquitin-like domain is suggestive of a new mechanism of Parkin activation.2022
- Author(s)
  Liu J-Y, Inoshita T, Shiba-Fukushima K, Yoshida K, Ishihama Y, Imai Y, Hattori N.
- Journal Title
  
  Hum Mol Genet.
  
  Volume: 31 Issue: 15 Pages: 2623-2638
- DOI
  10.1093/hmg/ddac064
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-21H04820, KAKENHI-PROJECT-20H03453, KAKENHI-PROJECT-20K21531
[Journal Article] Clinical Manifestations and Molecular Backgrounds of Parkinson's Disease Regarding Genes Identified From Familial and Population Studies2022
- Author(s)
  Nishioka Kenya、Imai Yuzuru、Yoshino Hiroyo、Li Yuanzhe、Funayama Manabu、Hattori Nobutaka
- Journal Title
  
  Frontiers in Neurology
  
  Volume: 13 Pages: 764917-764917
- DOI
  10.3389/fneur.2022.764917
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07283, KAKENHI-PROJECT-22K07542, KAKENHI-PROJECT-21H04820, KAKENHI-PROJECT-20H03453, KAKENHI-PROJECT-20K07893, KAKENHI-PROJECT-20K21531
[Journal Article] Pathophysiological evaluation of the LRRK2 G2385R risk variant for Parkinson’s disease.2022
- Author(s)
  Tezuka T, Taniguchi D, Sano M, Shimada T, Oji Y, Tsunemi T, Ikeda A, Li Y, Yoshino H, Ogata J, Shiba-Fukushima K, Funayama M, Nishioka K, Imai Y, Hattori N.
- Journal Title
  
  NPJ Parkinsons Dis.
  
  Volume: 8 Issue: 1 Pages: 97-97
- DOI
  10.1038/s41531-022-00367-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-21K07283, KAKENHI-PROJECT-21K07444, KAKENHI-PROJECT-22K07542, KAKENHI-PROJECT-22K15649, KAKENHI-PROJECT-20H03453, KAKENHI-PROJECT-20K07893, KAKENHI-PROJECT-20K21531
[Journal Article] Neurodegeneration-associated mitochondrial proteins, CHCHD2 and CHCHD10-what distinguishes the two?2022
- Author(s)
  Aya Ikeda
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 10 Pages: 1-12
- DOI
  10.3389/fcell.2022.996061
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16504, KAKENHI-PROJECT-21H04820, KAKENHI-PROJECT-20H03453, KAKENHI-PROJECT-20K21531
[Journal Article] α-Synuclein V15A variant in familial Parkinson's disease exhibits a weaker lipid-binding property.2022
- Author(s)
  Daida K, Shimonaka S, Shiba-Fukushima K, Ogata J, Yoshino H, Okuzumi A, Hatano T, Motoi Y, Hirunagi T, Katsuno M, Shindou H, Funayama M, Nishioka K, Hattori N, Imai Y.
- Journal Title
  
  Mov Disord.
  
  Volume: 37 Issue: 10 Pages: 2075-2085
- DOI
  10.1002/mds.29162
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-21K07424, KAKENHI-PROJECT-22K07542, KAKENHI-PROJECT-20K16160, KAKENHI-PROJECT-22K15649, KAKENHI-PROJECT-21H04820, KAKENHI-PROJECT-20H03453, KAKENHI-PROJECT-20K07893, KAKENHI-PROJECT-20K21531, KAKENHI-PROJECT-21K19443
[Journal Article] Parkinson disease-associated Leucine-rich repeat kinase regulates UNC-104-dependent axonal transport of Arl8-positive vesicles in Drosophila.2022
- Author(s)
  Inoshita T, Liu J-Y, Taniguchi D, Ishii R, Shiba-Fukushima K, Hattori N, Imai Y.
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 12 Pages: 105476-105476
- DOI
  10.1016/j.isci.2022.105476
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-22K06916, KAKENHI-PROJECT-21H04820, KAKENHI-PROJECT-20H03453, KAKENHI-PROJECT-19K07830, KAKENHI-PROJECT-20K21531
[Journal Article] A Novel LRRK2 Variant p.G2294R in the WD40 Domain Identified in Familial Parkinson’s Disease Affects LRRK2 Protein Levels2021
- Author(s)
  Ogata Jun、Hirao Kentaro、Nishioka Kenya、Hayashida Arisa、Li Yuanzhe、Yoshino Hiroyo、Shimizu Soichiro、Hattori Nobutaka、Imai Yuzuru
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 7 Pages: 3708-3708
- DOI
  10.3390/ijms22073708
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16929, KAKENHI-PROJECT-20H03453, KAKENHI-PROJECT-20K07893, KAKENHI-PROJECT-21K07283, KAKENHI-PROJECT-20K21531
[Journal Article] Syntaxin 17, an ancient SNARE paralog, plays different and conserved roles in different organisms2021
- Author(s)
  Kato Shun、Arasaki Kohei、Tokutomi Natsuki、Imai Yuzuru、Inoshita Tsuyoshi、Hattori Nobutaka、Sasaki Taeko、Sato Miyuki、Wakana Yuichi、Inoue Hiroki、Tagaya Mitsuo
- Journal Title
  
  Journal of Cell Science
  
  Volume: 134 Issue: 22
- DOI
  10.1242/jcs.258699
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19H05712, KAKENHI-PLANNED-20H05772, KAKENHI-PROJECT-20H03453, KAKENHI-PROJECT-21H02480, KAKENHI-PROJECT-20J01777, KAKENHI-PROJECT-20K21531, KAKENHI-PROJECT-23K21307
[Journal Article] UQCRC1 engages cytochrome c for neuronal apoptotic cell death2021
- Author(s)
  Hung Yu-Chien、Huang Kuan-Lin、Chen Po-Lin、Li Jeng-Lin、Lu Serena Huei-An、Chang Jui-Chih、Lin Han-Yi、Lo Wen-Chun、Huang Shu-Yi、Lee Tai-Ting、Lin Tai-Yi、Imai Yuzuru、Hattori Nobutaka、Liu Chin-San、Tsai Su-Yi、Chen Chun-Hong、Lin Chin-Hsien、Chan Chih-Chiang
- Journal Title
  
  Cell Reports
  
  Volume: 36 Issue: 12 Pages: 109729-109729
- DOI
  10.1016/j.celrep.2021.109729
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03453, KAKENHI-PROJECT-20K21531
[Journal Article] Editorial: Molecular Links Between Mitochondrial Damage and Parkinson's Disease and Related Disorders2021
- Author(s)
  Imai Yuzuru、Kim Kiyoung、Wu Zhihao、Sato Shigeto
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 9
- DOI
  10.3389/fcell.2021.734475
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03453, KAKENHI-PROJECT-20K21531
[Journal Article] High-fat diet-induced activation of SGK1 promotes Alzheimer’s disease-associated tau pathology2021
- Author(s)
  Elahi Montasir、Motoi Yumiko、Shimonaka Shotaro、Ishida Yoko、Hioki Hiroyuki、Takanashi Masashi、Ishiguro Koichi、Imai Yuzuru、Hattori Nobutaka
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 30 Issue: 18 Pages: 1693-1710
- DOI
  10.1093/hmg/ddab115
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03453, KAKENHI-PROJECT-20K21531, KAKENHI-PROJECT-20K16160
[Journal Article] Lipids: Key Players That Modulate -Synuclein Toxicity and Neurodegeneration in Parkinson’s Disease2020
- Author(s)
  Akio Mori, Yuzuru Imai, Nobutaka Hattori
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 9 Pages: 9-9
- DOI
  10.3390/ijms21093301
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15376, KAKENHI-PROJECT-19K22603, KAKENHI-PROJECT-20K21531, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-20H03453
[Journal Article] A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling2020
- Author(s)
  Shiba-Fukushima Kahori、Inoshita Tsuyoshi、Sano Osamu、Iwata Hidehisa、Ishikawa Kei-ichi、Okano Hideyuki、Akamatsu Wado、Imai Yuzuru、Hattori Nobutaka
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 5 Pages: 101048-101048
- DOI
  10.1016/j.isci.2020.101048
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07873, KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-17H04049, KAKENHI-PROJECT-17K09765
[Journal Article] Reduced astrocytic reactivity in human brains and midbrain organoids with PRKN mutations2020
- Author(s)
  Kano Masayoshi、Takanashi Masashi、Oyama Genko、Yoritaka Asako、Hatano Taku、Shiba-Fukushima Kahori、Nagai Makiko、Nishiyama Kazutoshi、Hasegawa Kazuko、Inoshita Tsuyoshi、Ishikawa Kei-ichi、Akamatsu Wado、Imai Yuzuru、Bolognin Silvia、Schwamborn Jens Christian、Hattori Nobutaka
- Journal Title
  
  npj Parkinson's Disease
  
  Volume: 6 Issue: 1 Pages: 33-33
- DOI
  10.1038/s41531-020-00137-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07873, KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-17H04049, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-17K09765
[Journal Article] Editorial for the Special Issue “Animal Models of Parkinson’s Disease and Related Disorders”2020
- Author(s)
  Imai Y
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 21 Issue: 12 Pages: 4250-4250
- DOI
  10.3390/ijms21124250
- Open Access
- Data Source
  KAKENHI-PROJECT-20K21531, KAKENHI-PROJECT-20H03453
[Journal Article] A novel rare variant of LRRK2 associated with familial Parkinson's disease: p.R1501W2020
- Author(s)
  Masuzugawa S, Nishioka K, Imai Y, Ogata J, Shojima Y, Li Y, Yoshino H, Hattori N.
- Journal Title
  
  Parkinsonism and Related Disorders.
  
  Volume: 76 Pages: 46-48
- DOI
  10.1016/j.parkreldis.2020.05.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07893, KAKENHI-PROJECT-17H04049
[Journal Article] PINK1-Parkin signaling in Parkinson's disease: Lessons from Drosophila.2020
- Author(s)
  Imai Y
- Journal Title
  
  Neurosci Res.
  
  Volume: 159 Pages: 40-46
- DOI
  10.1016/j.neures.2020.01.016
- Data Source
  KAKENHI-PROJECT-17H04049, KAKENHI-PROJECT-20H03453
[Journal Article] Identifying Therapeutic Agents for Amelioration of Mitochondrial Clearance Disorder in Neurons of Familial Parkinson Disease2020
- Author(s)
  Yamaguchi Akihiro、Ishikawa Kei-ichi、Inoshita Tsuyoshi、Shiba-Fukushima Kahori、Saiki Shinji、Hatano Taku、Mori Akio、Oji Yutaka、Okuzumi Ayami、Li Yuanzhe、Funayama Manabu、Imai Yuzuru、Hattori Nobutaka、Akamatsu Wado
- Journal Title
  
  Stem Cell Reports
  
  Volume: 14 Issue: 6 Pages: 1060-1075
- DOI
  10.1016/j.stemcr.2020.04.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08003, KAKENHI-PROJECT-20K07873, KAKENHI-PROJECT-20K07910, KAKENHI-PROJECT-17H04049, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-17K09765
[Journal Article] Twin CHCH Proteins, CHCHD2, and CHCHD10: Key Molecules of Parkinson’s Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia2019
- Author(s)
  Imai Yuzuru、Meng Hongrui、Shiba-Fukushima Kahori、Hattori Nobutaka
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 4 Pages: 908-908
- DOI
  10.3390/ijms20040908
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15465, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-17H04049, KAKENHI-PROJECT-16K19525
[Journal Article] Regulation of membrane dynamics by Parkinson’s disease-associated genes.2018
- Author(s)
  Inoshita T, Cui C, Hattori N, Imai Y
- Journal Title
  
  J Genet.
  
  Volume: 97 Pages: 715-727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04049
[Journal Article] Syntaxin 17 regulates the localization and function of PGAM5 in mitochondrial division and mitophagy2018
- Author(s)
  Sugo Masashi、Kimura Hana、Arasaki Kohei、Amemiya Toshiki、Hirota Naohiko、Dohmae Naoshi、Imai Yuzuru、Inoshita Tsuyoshi、Shiba‐Fukushima Kahori、Hattori Nobutaka、Cheng Jinglei、Fujimoto Toyoshi、Wakana Yuichi、Inoue Hiroki、Tagaya Mitsuo
- Journal Title
  
  The EMBO Journal
  
  Volume: 37 Issue: 21
- DOI
  10.15252/embj.201798899
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06138, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05902, KAKENHI-PROJECT-18H04023, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-17H04049, KAKENHI-PROJECT-18H02439, KAKENHI-PROJECT-18H02656
[Journal Article] Reduced TDP-43 Expression Improves Neuronal Activities in a Drosophila Model of Perry Syndrome2017
- Author(s)
  Hosaka Y, Inoshita T, Shiba-Fukushima K, Cui C, Arano T, Imai Y, Hattori N
- Journal Title
  
  EBioMedicine
  
  Volume: 21 Pages: 218-227
- DOI
  10.1016/j.ebiom.2017.06.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293070
[Journal Article] Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila2017
- Author(s)
  Inoshita Tsuyoshi、Arano Taku、Hosaka Yuka、Meng Hongrui、Umezaki Yujiro、Kosugi Sakiko、Morimoto Takako、Koike Masato、Chang Hui-Yun、Imai Yuzuru、Hattori Nobutaka
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 26 Issue: 15 Pages: 2933-2948
- DOI
  10.1093/hmg/ddx179
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09679, KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-17H04049
[Journal Article] Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c.2017
- Author(s)
  Meng H, Yamashita C, Shiba-Fukushima K, Inoshita T, Funayama M, Sato S, Hatta T, Natsume T, Umitsu M, Takagi J, Imai Y, Hattori N.
- Journal Title
  
  Nat Commun
  
  Volume: 8 Issue: 1 Pages: 15500-15500
- DOI
  10.1038/ncomms15500
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09676, KAKENHI-PROJECT-16K19525, KAKENHI-PROJECT-26293070, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-15KK0354, KAKENHI-PROJECT-17H01420
[Journal Article] 遺伝子から探るパーキンソン病病態へのミトコンドリアの関与2017
- Author(s)
  今居　譲、柴佳保里、服部信孝
- Journal Title
  
  医学のあゆみ
  
  Volume: 260 Pages: 85-91
- Data Source
  KAKENHI-PROJECT-16K15484
[Journal Article] ミトコンドリア機能障害とパーキンソン病2017
- Author(s)
  今居　譲
- Journal Title
  
  日本臨牀
  
  Volume: 75 Pages: 28-35
- Data Source
  KAKENHI-PROJECT-16K15484
[Journal Article] Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson’s disease2017
- Author(s)
  Shiba-Fukushima Kahori、Ishikawa Kei-Ichi、Inoshita Tsuyoshi、Izawa Nana、Takanashi Masashi、Sato Shigeto、Onodera Osamu、Akamatsu Wado、Okano Hideyuki、Imai Yuzuru、Hattori Nobutaka
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 26 Pages: 3172-3185
- DOI
  10.1093/hmg/ddx201
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09677, KAKENHI-PROJECT-17K09765, KAKENHI-PROJECT-26293070, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-26461280, KAKENHI-PROJECT-16K15484, KAKENHI-PROJECT-16K19524, KAKENHI-PUBLICLY-17H05706
[Journal Article] Mitochondrial-Associated Membranes in Parkinson's Disease.2017
- Author(s)
  Hattori N, Arano T, Hatano T, Mori A, Imai Y
- Journal Title
  
  Advances in Experimental Medical Biology
  
  Volume: 997 Pages: 157-169
- DOI
  10.1007/978-981-10-4567-7_12
- ISBN
  9789811045660, 9789811045677
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09675, KAKENHI-PROJECT-17H04049
[Journal Article] 遺伝子から探るパーキンソン病病態へのミトコンドリアの関与2017
- Author(s)
  今居　譲、柴佳保里、服部信孝
- Journal Title
  
  医学のあゆみ
  
  Volume: 260 Pages: 85-91
- Data Source
  KAKENHI-PROJECT-26293070
[Journal Article] ミトコンドリア機能障害とパーキンソン病2017
- Author(s)
  今居　譲
- Journal Title
  
  日本臨牀
  
  Volume: 75 Pages: 28-35
- Data Source
  KAKENHI-PROJECT-26293070
[Journal Article] Quantitative Assessment of Eye Phenotypes for Functional Genetic Studies Using Drosophila melanogaster.2016
- Author(s)
  Iyer J, Wang Q, Le T, Pizzo L, Gronke S, Ambegaokar S, Imai Y, Srivastava A, Llamusi Trois B, Mardon G, Artero R, Jackson GR, Isaacs AM, Partridge L, Kumar JP, Girirajan S.
- Journal Title
  
  G3
  
  Volume: - Issue: 5 Pages: 1427-1437
- DOI
  10.1534/g3.116.027060
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293070
[Journal Article] Functional Neurons Generated from T Cell-Derived Induced Pluripotent Stem Cells2016
- Author(s)
  Matsumoto T, Fujimori K, Andoh-Noda T, Ando T, Kuzumaki N, Toyoshima M, Tada H, Imaizumi K, Ishikawa M, Yamaguchi R, Isoda M, Zhou Z, Sato S, Kobayashi T, Ohtaka M, Nishimura K, Kurosawa H, Yoshikawa T, Takahashi T, Nakanishi M, Ohyama M, Hattori N, Akamatsu W, Okano H.
- Journal Title
  
  Stem Cell Reports.
  
  Volume: 6 Issue: 3 Pages: 422-35
- DOI
  10.1016/j.stemcr.2016.01.010
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06780, KAKENHI-PROJECT-15K09849, KAKENHI-PROJECT-15K15041, KAKENHI-PROJECT-26830018, KAKENHI-PLANNED-23111003, KAKENHI-PLANNED-24116002, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-26870074, KAKENHI-ORGANIZER-24116001, KAKENHI-PROJECT-16K08280
[Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)2016
- Author(s)
  Klionsky DJ., Abdelmohsen K., Abe A., Abedin MJ.,Inomata M., et al.
- Journal Title
  
  Autophagy
  
  Volume: 12(1) Issue: 1 Pages: 1-222
- DOI
  10.1080/15548627.2015.1100356
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11094, KAKENHI-PROJECT-15K14681, KAKENHI-PROJECT-15K14951, KAKENHI-PUBLICLY-15H01239, KAKENHI-PUBLICLY-15H01380, KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118007, KAKENHI-PLANNED-26110003, KAKENHI-PUBLICLY-26111501, KAKENHI-PUBLICLY-26111503, KAKENHI-PUBLICLY-26111505, KAKENHI-PUBLICLY-26111514, KAKENHI-PUBLICLY-26111521, KAKENHI-PUBLICLY-26117727, KAKENHI-PROJECT-15H05298, KAKENHI-PROJECT-15H06095, KAKENHI-PROJECT-25460072, KAKENHI-PROJECT-25461364, KAKENHI-PROJECT-25462920, KAKENHI-PROJECT-26670446, KAKENHI-PROJECT-26670906, KAKENHI-PROJECT-25850198, KAKENHI-PROJECT-25290014, KAKENHI-PROJECT-25291040, KAKENHI-PROJECT-25291042, KAKENHI-PROJECT-25293383, KAKENHI-PROJECT-26290018, KAKENHI-PROJECT-26291039, KAKENHI-PROJECT-26292032, KAKENHI-PROJECT-26293179, KAKENHI-PROJECT-26713005, KAKENHI-PUBLICLY-15H01545, KAKENHI-PUBLICLY-15H01572, KAKENHI-ORGANIZER-25111001, KAKENHI-PLANNED-25111003, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-26253094, KAKENHI-PROJECT-16H05291, KAKENHI-PROJECT-16J00431, KAKENHI-PROJECT-26293070, KAKENHI-PROJECT-26293207, KAKENHI-PROJECT-25711005, KAKENHI-PROJECT-26430050, KAKENHI-PROJECT-15K06791, KAKENHI-PROJECT-15K08376, KAKENHI-PROJECT-15K10908, KAKENHI-PROJECT-15K11079, KAKENHI-PROJECT-15K12749, KAKENHI-PROJECT-16K15194, KAKENHI-PROJECT-16K15790, KAKENHI-PROJECT-16K15853, KAKENHI-PROJECT-15K16486, KAKENHI-PROJECT-16H05107, KAKENHI-PROJECT-20H03453
[Journal Article] Current Topics「PINK1とParkinが紡ぐリン酸化ポリユビキチンの鎖が、Parkinをミトコンドリアへと局在化させる」2015
- Author(s)
  今居　譲、柴佳保里、服部信孝
- Journal Title
  
  実験医学
  
  Volume: 33 Pages: 940-943
- Data Source
  KAKENHI-PUBLICLY-26117727
[Journal Article] The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway.2015
- Author(s)
  Imai Y, Kobayashi Y, Inoshita T, Meng H, Arano T, Uemura K, Asano T, Yoshimi K, Zhang CL, Matsumoto G, Ohtsuka T, Kageyama R, Kiyonari H, Shioi G, Nukina N, Hattori N, Takahashi R
- Journal Title
  
  PLoS Genet.
  
  Volume: 11 Issue: 9 Pages: e1005503-e1005503
- DOI
  10.1371/journal.pgen.1005503
- NAID
  120005946994
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06773, KAKENHI-PROJECT-26860219, KAKENHI-PLANNED-23111002, KAKENHI-PUBLICLY-15H01561, KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-15H02540, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-26670442
[Journal Article] Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology.2015
- Author(s)
  Vaikath NN, Majbour NK, Paleologou KE, Ardah MT, van Dam E, van de Berg WD, Forrest SL, Parkkinen L, Gai WP, Hattori N, Takanashi M, Lee SJ, Mann DM, Imai Y, Halliday GM, Li JY, El-Agnaf OM.
- Journal Title
  
  Neurobiol Dis.
  
  Volume: 79 Pages: 81-99
- DOI
  10.1016/j.nbd.2015.04.009
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-26293070
[Journal Article] Current Topics「PINK1とParkinが紡ぐリン酸化ポリユビキチンの鎖が、Parkinをミトコンドリアへと局在化させる」2015
- Author(s)
  今居　譲、柴佳保里、服部信孝
- Journal Title
  
  実験医学
  
  Volume: 33 Pages: 940-943
- Data Source
  KAKENHI-PROJECT-26293070
[Journal Article] PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila2014
- Author(s)
  Kahori Shiba-Fukushima, Tsuyoshi Inoshita, Nobutaka Hattori, Yuzuru Imai
- Journal Title
  
  Plos genetics
  
  Volume: 電子媒体
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24780048
[Journal Article] Lysine 63-linked polyubiquitination is dispensable for Parkin-mediated mitophagy.2014
- Author(s)
  Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y.
- Journal Title
  
  J Biol Chem.
  
  Volume: 289 Issue: 48 Pages: 33131-6
- DOI
  10.1074/jbc.c114.580944
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-24390224, KAKENHI-PUBLICLY-26117727, KAKENHI-PROJECT-26293070, KAKENHI-PROJECT-26461280
[Journal Article] Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering.2014
- Author(s)
  Shiba-Fukushima K, Arano T, Matsumoto G, Inoshita T, Yoshida S, Ishihama Y, Ryu KY, Nukina N, Hattori N, Imai Y.
- Journal Title
  
  PLoS Genet.
  
  Volume: 10 Issue: 12 Pages: 1004861-1004861
- DOI
  10.1371/journal.pgen.1004861
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-23500434, KAKENHI-PROJECT-24241062, KAKENHI-PROJECT-24390224, KAKENHI-PUBLICLY-26117727, KAKENHI-PROJECT-26293070, KAKENHI-PROJECT-26461280, KAKENHI-PROJECT-26860219
[Journal Article] Regulation by mitophagy2014
- Author(s)
  Hattori N, Saiki S, Imai Y.
- Journal Title
  
  Int J Biochem Cell Biol.
  
  Volume: 53 Pages: 147-50
- DOI
  10.1016/j.biocel.2014.05.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-24390224, KAKENHI-PLANNED-25111007, KAKENHI-PUBLICLY-26117727, KAKENHI-PROJECT-26293070
[Journal Article] ショウジョウバエを用いた遺伝性パーキンソン病の発症機序の研究2014
- Author(s)
  今居　譲
- Journal Title
  
  Aging & Health
  
  Volume: 23 Pages: 38-41
- Data Source
  KAKENHI-PROJECT-26293070
[Journal Article] PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila.2014
- Author(s)
  Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y.
- Journal Title
  
  PLoS Genet.
  
  Volume: Jun 5;10(6) Issue: 6 Pages: 1004391-1004391
- DOI
  10.1371/journal.pgen.1004391
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-24390224, KAKENHI-PROJECT-24790896, KAKENHI-PUBLICLY-26117727, KAKENHI-PROJECT-26293070, KAKENHI-PROJECT-26461280, KAKENHI-PROJECT-26860219
[Journal Article] ショウジョウバエを用いた遺伝性パーキンソン病の発症機序の研究2014
- Author(s)
  今居　譲
- Journal Title
  
  Aging & Health
  
  Volume: 23 Pages: 38-41
- Data Source
  KAKENHI-PUBLICLY-26117727
[Journal Article] Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance2013
- Author(s)
  Wu Z, Sawada T, Shiba K, Liu S, Kanao T, Takahashi R, Hattori N, Imai Y, Lu B
- Journal Title
  
  Genes Dev
  
  Volume: 27 Pages: 157-162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790973
[Journal Article] PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy2012
- Author(s)
  Shiba-Fukushima K, Imai Y, Yoshida S, Ishihama Y, Kanao T, Sato S, Hattori N
- Journal Title
  
  Sci Rep
  
  Volume: 2: Article number: 1002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790973
[Journal Article] Mitochondrial regulation by the PINK1-Parkin signaling2012
- Author(s)
  Yuzuru Imai
- Journal Title
  
  ISRN Cell Biology
  
  Volume: 2012 Pages: 926160-926160
- DOI
  10.5402/2012/926160
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790973
[Journal Article] Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria2012
- Author(s)
  Liu S, Sawada T, Lee S, Yu W, Silverio G, Alapatt P, Millan I, Shen A, Saxton WM, Kanao T, Takahashi R, Hattori N, Imai Y, Lu B
- Journal Title
  
  PLoS Genet
  
  Volume: 8:e1002537
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790973
[Journal Article] Mitochondrial regulation by the PINK1-Parkin signaling2012
- Author(s)
  Imai Y
- Journal Title
  
  ISRN Cell Biol
  
  Volume: Article ID 926160
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790973
[Journal Article] 神経変性疾患に関与するmiRNAとその臨床応用への可能性2012
- Author(s)
  今居　譲
- Journal Title
  
  遺伝子医学MOOK
  
  Volume: 23 Pages: 44-47
- Data Source
  KAKENHI-PUBLICLY-23110502
[Journal Article] モデルショウジョウバエを用いた遺伝性若年性パーキンソン病の研究2012
- Author(s)
  今居譲
- Journal Title
  
  自律神経
  
  Volume: (印刷中)
- NAID
  10031163529
- Data Source
  KAKENHI-PUBLICLY-23110502
[Journal Article] Editorial; Animal models of Parkinson’s disease.2012
- Author(s)
  Yuzuru Imai
- Journal Title
  
  Parkinsons Disease
  
  Volume: 2012 Pages: 729428-729428
- DOI
  10.1155/2012/729428
- Data Source
  KAKENHI-PROJECT-23790973
[Journal Article] Editorial; Animal models of Parkinson’s disease.2012
- Author(s)
  Yuzuru Imai
- Journal Title
  
  Parkinsons Disease
  
  Volume: 2012 Pages: 729428-729428
- Data Source
  KAKENHI-PUBLICLY-23110502
[Journal Article] Animal models of Parkinson's disease2012
- Author(s)
  Imai Y, Venderova K, Lim K-L: Editorial
- Journal Title
  
  Parkinsons Dis
  
  Volume: Article ID 729428
- Data Source
  KAKENHI-PROJECT-23790973
[Journal Article] Mitochondrial Dynamics and Mitophagy in Parkinson's disease: Disordered cellular power plant becomes a big deal in a major movement disorder2011
- Author(s)
  Imai Y, Lu B
- Journal Title
  
  Curr Opin Neurobiol
  
  Volume: 21 Pages: 935-941
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790973
[Journal Article] Dysregulation of microRNA-mediated translational repression is involved in neurodegeneration in a Drosophila model of Parkinson's disease2011
- Author(s)
  Imai Yuzuru
- Journal Title
  
  Bulletin
  
  Volume: 75 Pages: 39-56
- Data Source
  KAKENHI-PUBLICLY-23110502
[Journal Article] Mitochondrial Dynamics and Mitophagy in Parkinson's disease : Disordered cellular power plant becomes a big deal in a major movement disorder2011
- Author(s)
  Imai Yuzuru
- Journal Title
  
  Curr Opin Neurobiol
  
  Volume: 21 Pages: 935-941
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790302
[Journal Article] Dysregulation of microRNA-mediated translational repression is involved in neurodegeneration in a Drosophila model of Parkinson's disease2011
- Author(s)
  Imai, Y.
- Journal Title
  
  Bulletin
  
  Volume: 75 Pages: 39-56
- Data Source
  KAKENHI-PROJECT-21790302
[Journal Article] Dysregulation of microRNA-mediated translational repression is involved in neurodegeneration in a Drosophila model of Parkinson’s disease2011
- Author(s)
  Imai Yuzuru
- Journal Title
  
  Bulletin
  
  Volume: 75 Pages: 39-56
- Data Source
  KAKENHI-PROJECT-23790973
[Journal Article] Animal models of Parkinson's disease2011
- Author(s)
  Imai Y, Venderova K, Park DS, Cai H, Schmidt E: Editorial
- Journal Title
  
  Parkinsons Dis
  
  Volume: Article ID 364328
- Data Source
  KAKENHI-PROJECT-23790973
[Journal Article] Editorial ; Animal models of Parkinson's disease2011
- Author(s)
  Imai Yuzuru
- Journal Title
  
  Parkinsons Dis
- Data Source
  KAKENHI-PROJECT-21790302
[Journal Article] Editorial ; Animal models of Parkinson's disease2011
- Author(s)
  Imai Yuzuru
- Journal Title
  
  Parkinsons Dis
  
  Volume: 2011 Pages: 364328-364328
- DOI
  10.4061/2011/364328
- Data Source
  KAKENHI-PUBLICLY-23110502, KAKENHI-PROJECT-23790973
[Journal Article] Editorial; Animal models of Parkinson's disease2011
- Author(s)
  Imai, Y., Venderova, K., Park, DS., Cai, H., Schmidt, E.
- Journal Title
  
  Parkinsons Dis
  
  Volume: Article ID 364328
- Data Source
  KAKENHI-PROJECT-21790302
[Journal Article] Mitochondrial Dynamics and Mitophagy in Parkinson's disease: Disordered cellular power plant becomes a big deal in a major movement disorder2011
- Author(s)
  Imai, Y., Lu, B.
- Journal Title
  
  Curr Opin Neurobiol
  
  Volume: 21 Pages: 935-941
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790302
[Journal Article] Mitochondrial Dynarnics and Mitophagy in Parkinson's disease : Disordered cellular power plant becomes a big deal in a major movement disorder2011
- Author(s)
  Imai Yuzuru
- Journal Title
  
  Curr Opin Neurobiol
  
  Volume: 21 Issue: 6 Pages: 935-941
- DOI
  10.1016/j.conb.2011.10.016
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23110502, KAKENHI-PROJECT-23790973
[Journal Article] Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression2010
- Author(s)
  Gehrke, S., Imai, Y., Sokol, N., Lu, B.
- Journal Title
  
  Nature
  
  Volume: 466 Pages: 637-641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790302
[Journal Article] The Loss of PGAM5 Suppresses the Mitochondrial Degeneration Caused by Inactivation of PINK1 in Drosophila2010
- Author(s)
  Imai Y., et al
- Journal Title
  
  PLoS Genet
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790302
[Journal Article] The Loss of PGAM5 Suppresses the Mitochondrial Degeneration Caused by Inactivation of PINK1 in Drosophila2010
- Author(s)
  Imai, Y., Kanao, T., Sawada, T., Kobayashi, Y., Moriwaki, Y., Ishida, Y., Takeda, K., Ichijo, H., Lu, B., Takahashi, R.
- Journal Title
  
  PLoS Genet
  
  Volume: e1001229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790302
[Journal Article] Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila2010
- Author(s)
  Kanao, T., Venderova, K., Park, DS., Unterman, T., Lu, B., Imai, Y.
- Journal Title
  
  Hum Mol Genet
  
  Volume: 19 Pages: 3747-3758
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790302
[Journal Article] Parkin and ER strtess. Molecular Mechanisms in Parkinson' s disease.2005
- Author(s)
  Imai, Y.
- Journal Title
  
  Bioscience (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207032
[Journal Article] How do Parkin mutations result in neurodegeneration?2004
- Author(s)
  Imai, Y.
- Journal Title
  
  Current Opinion in Neurobiology 14・3
  
  Pages: 384-389
- Data Source
  KAKENHI-PROJECT-15680011
[Journal Article] How do Parkin mutation result in neurodegeneration?2004
- Author(s)
  Imai, Y., Takahashi, R.
- Journal Title
  
  Curr.Opin.Neurobiol. 14
  
  Pages: 384-389
- Data Source
  KAKENHI-PROJECT-14207032
[Journal Article] Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila.2003
- Author(s)
  Yang, Y., Nishimura, I., Imai, Y., Takahashi, R., Lu, B.
- Journal Title
  
  Neuron 37
  
  Pages: 911-924
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207032
[Journal Article] Parkin and ER stress.2003
- Author(s)
  Takahashi, R., Imai, Y., Hattori, N., Mizuno, Y
- Journal Title
  
  Ann.N.Y.Acad.Sci. 991
  
  Pages: 101-106
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207032
[Journal Article] CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.2002
- Author(s)
  Imai, Y.
- Journal Title
  
  Mol.Cell 10
  
  Pages: 55-67
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207032
[Journal Article] CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.2002
- Author(s)
  Imai, Y., Soda, M., Hatakeyama, S., Akagi, T., Hashikawa, T., Nakayama, K-I., Takahashi.R
- Journal Title
  
  Mol.Cell 10
  
  Pages: 55-67
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207032
[Patent] ミトコンドリア品質管理酵素Parkin活性化剤のスクリーニング法2016
- Inventor(s)
  今居　譲、服部信孝、福嶋佳保里、荒野　拓
- Industrial Property Rights Holder
  今居　譲、服部信孝、福嶋佳保里、荒野　拓
- Industrial Property Rights Type
  特許
- Filing Date
  2016-02-01
- Data Source
  KAKENHI-PUBLICLY-26117727
[Presentation] Loss of MPAN-associated C19orf12 causes alteration of lipid metabolism and autophagosome-lysosome trafficking in Drosophila.2022
- Author(s)
  Shiina K, Mori A, Miki Y, Murakami M, Ueno N, Miura Y, Hatano T, Imai Y, Hattori N
- Organizer
  8th International symposium on NBIA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21531
[Presentation] Loss of MPAN-associated C19orf12 causes alteration of lipid metabolism and autophagosome-lysosome trafficking in Drosophila.2022
- Author(s)
  Shiina K, Mori A, Miki Y, Murakami M, Ueno N, Miura Y, Hatano T, Imai Y, Hattori N
- Organizer
  8th International symposium on NBIA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03453
[Presentation] Ubiquitination at the lysine 27 residue of the Parkin ubiquitin-like domain is suggestive of a new mechanism of Parkin activation.2022
- Author(s)
  Liu J-Y, Inoshita T, Shiba-Fukushima K, Hattori N, Imai Y
- Organizer
  Neuro2022
- Data Source
  KAKENHI-PROJECT-20K21531
[Presentation] Drosophila VPS13 regulates neuronal synaptic activity and mitochondrial homeostasis.2022
- Author(s)
  Shiba-Fukushima K, Inoshita T, Imai Y, Hattori N
- Organizer
  Neuro2022
- Data Source
  KAKENHI-PROJECT-20K21531
[Presentation] Loss of MPAN-associated C19orf12 causes alteration of lipid metabolism in Drosophila.2022
- Author(s)
  Shiina K, Mori A, Miki Y, Murakami M, Ueno N, Miura Y, Hatano T, Imai Y, Hattori N
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20H03453
[Presentation] Ubiquitination at the lysine 27 residue of the Parkin ubiquitin-like domain is suggestive of a new mechanism of Parkin activation.2022
- Author(s)
  Liu J-Y, Inoshita T, Shiba-Fukushima K, Hattori N, Imai Y
- Organizer
  Neuro2022
- Data Source
  KAKENHI-PROJECT-20H03453
[Presentation] Screening of lipid species and associated enzymes that participate in α-synuclein aggregation.2022
- Author(s)
  Kasahara R, Ogata J, Shiina K, Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y
- Organizer
  MBSJ2022
- Data Source
  KAKENHI-PROJECT-20H03453
[Presentation] 若年性パーキンソン病原因遺伝子産物Parkinの活性化メカニズムの新規知見2022
- Author(s)
  今居　譲
- Organizer
  第95回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03453
[Presentation] Screening of lipid species and associated enzymes that participate in α-synuclein aggregation.2022
- Author(s)
  Kasahara R, Ogata J, Shiina K, Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y
- Organizer
  MBSJ2022
- Data Source
  KAKENHI-PROJECT-20K21531
[Presentation] Loss of MPAN-associated C19orf12 causes alteration of lipid metabolism in Drosophila.2022
- Author(s)
  Shiina K, Mori A, Miki Y, Murakami M, Ueno N, Miura Y, Hatano T, Imai Y, Hattori N
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K21531
[Presentation] Drosophila VPS13 regulates neuronal synaptic activity and mitochondrial homeostasis.2022
- Author(s)
  Shiba-Fukushima K, Inoshita T, Imai Y, Hattori N
- Organizer
  Neuro2022
- Data Source
  KAKENHI-PROJECT-20H03453
[Presentation] Two novel variants in CHCHD2 associate with TDP-43 pathology among amyotrophic lateral sclerosis.2022
- Author(s)
  Ikeda A, Funayama M, Yoshida M, Li Y, Inoshita T, Shiba-Fukushima K, Meng H, Amo T, Aiba I, Saito Y, Atsuta N, Nakamura R, Tohnai G, Sone J, Izumi Y, Kaji R, Morita M, Taniguchi A, Nishioka K, Imai Y, Sobue G, Hattori N, JaCALS
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K21531
[Presentation] Two novel variants in CHCHD2 associate with TDP-43 pathology among amyotrophic lateral sclerosis.2022
- Author(s)
  Ikeda A, Funayama M, Yoshida M, Li Y, Inoshita T, Shiba-Fukushima K, Meng H, Amo T, Aiba I, Saito Y, Atsuta N, Nakamura R, Tohnai G, Sone J, Izumi Y, Kaji R, Morita M, Taniguchi A, Nishioka K, Imai Y, Sobue G, Hattori N, JaCALS
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20H03453
[Presentation] 若年性パーキンソン病原因遺伝子産物Parkinの活性化メカニズムの新規知見2022
- Author(s)
  今居　譲
- Organizer
  第95回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K21531
[Presentation] αシヌクレインの凝集要因、生体膜脂質とミトコンドリア2021
- Author(s)
  今居　譲
- Organizer
  第35回日本大脳基底核研究会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03453
[Presentation] αシヌクレインの凝集要因、生体膜脂質とミトコンドリア2021
- Author(s)
  今居　譲
- Organizer
  第35回日本大脳基底核研究会
- Invited
- Data Source
  KAKENHI-PROJECT-20K21531
[Presentation] ミトコンドリア変性とパーキンソン病2021
- Author(s)
  今居　譲
- Organizer
  第20回日本ミトコンドリア学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K21531
[Presentation] Mechanism of α-Synuclein aggregation by the disturbance of biomembrane remodelling2021
- Author(s)
  Imai Y
- Organizer
  “LIFS Seminar Series”, at Devision of Life Science, Hong Kong University of Science and Technology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03453
[Presentation] ミトコンドリア変性とパーキンソン病2021
- Author(s)
  今居　譲
- Organizer
  第20回日本ミトコンドリア学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03453
[Presentation] パーキンソン病病態に関与するリン脂質変化2020
- Author(s)
  今居　譲
- Organizer
  第 63 回日本神経化学会大会公募シンポジウム７「脂質が制御する神経機能」
- Invited
- Data Source
  KAKENHI-PROJECT-20K21531
[Presentation] パーキンソン病病態に関与するリン脂質変化2020
- Author(s)
  今居　譲
- Organizer
  第 63 回日本神経化学会大会公募シンポジウム７「脂質が制御する神経機能」
- Invited
- Data Source
  KAKENHI-PROJECT-17H04049
[Presentation] Mechanism of α-Synuclein aggregation by the disturbance of biomembrane remodelling.2020
- Author(s)
  Imai Y
- Organizer
  “LIFS Seminar Series”, at Devision of Life Science, Hong Kong University of Science and Technology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04049
[Presentation] Mechanism of α-Synuclein aggregation by the disturbance of biomembrane remodelling.2020
- Author(s)
  Yuzuru Imai
- Organizer
  LIFS Seminar Series”, at Devision of Life Science, Hong Kong University of Science and Technology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21531
[Presentation] パーキンソン病病態に関与するリン脂質変化2020
- Author(s)
  今居　譲
- Organizer
  第 63 回日本神経化学会大会公募シンポジウム７「脂質が制御する神経機能」
- Invited
- Data Source
  KAKENHI-PROJECT-20H03453
[Presentation] The axonal transport of mitochondria regulated by PINK1-Parkin signaling: Lessons from Drosophila2018
- Author(s)
  Y. Imai
- Organizer
  “The 20th aniversary of Parkin discovery” Elsevier/NSR symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04049
[Presentation] Reduced TDP-43 expression improves axonal transport and synaptic activity in a Drosophila model of Perry syndrome2017
- Author(s)
  Hosaka Y, Inoshita T, Cui C, Arano T, Shiba K, Imai Y, Hattori H
- Organizer
  World Congress of Neurology
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] Genetic association study of Parkinson's disease-related genes that control synaptic vesicle dynamics2017
- Author(s)
  崔長旭、井下強、服部信孝、今居譲
- Organizer
  第40回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17H04049
[Presentation] Vps35 in cooperation with LRRK2 regulates synaptic vesicle recycling through the endosomal pathway2017
- Author(s)
  井下強、崔長旭、荒野拓、穂坂有加、孟紅蕊、梅崎勇次郎、小杉紗紀子、森本高子、小池正人、Chang Hui-Yun、今居譲、服部信孝
- Organizer
  第40回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17H04049
[Presentation] パーキンソン病原因遺伝子産物CHCHD2の生理的機能とその変異による病態への関与2017
- Author(s)
  今居　譲
- Organizer
  第15回神経科学研究会
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] パーキンソン病原因遺伝子 Vps35はシナプス小胞再生関連遺伝子と協働して神経伝達を制御する2017
- Author(s)
  井下強、荒野拓、穂坂有加、孟紅蕊、梅崎勇次郎、小杉紗紀子、森本高子、小池正人、Chang Hui-Yun、今居譲、服部信孝
- Organizer
  ConBio2017
- Invited
- Data Source
  KAKENHI-PROJECT-17H04049
[Presentation] ミトコンドリアの機能維持に関与するパーキンソン病遺伝子の解析2017
- Author(s)
  今居　譲
- Organizer
  ミトコンドリア機能研究会
- Invited
- Data Source
  KAKENHI-PROJECT-16K15484
[Presentation] ミトコンドリアの機能維持に関与するパーキンソン病遺伝子の解析2017
- Author(s)
  今居　譲
- Organizer
  ミトコンドリア機能研究会
- Invited
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] ミトコンドリアの機能維持に関与するパーキンソン病原因遺伝子の解析2017
- Author(s)
  今居　譲
- Organizer
  ミトコンドリア機能研究会
- Place of Presentation
  大阪市
- Invited
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] ミトコンドリアの機能を司るパーキンソン病原因遺伝子2017
- Author(s)
  今居　譲
- Organizer
  Agilent Technologies XF User Group Meeting Japan
- Invited
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial cristae structure and facilitates cytochrome c release from mitochondria2017
- Author(s)
  Meng H, Yamashita C, Shiba-Fukushima K, Inoshita T, Imai Y, Hattori N
- Organizer
  第40回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] PINK1-Parkinシグナル伝達に関与する新規分子の解析2017
- Author(s)
  柴佳保里、井下強、青木裕子、石濱泰、今居譲、服部信孝
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-17H04049
[Presentation] パーキンソン病原因遺伝子CHCHD2の機能解析2017
- Author(s)
  今居　譲
- Organizer
  カテコールアミンと神経疾患研究会
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] PINK1-Parkinシグナル伝達に関与する新規分子の解析2017
- Author(s)
  柴佳保里、井下強、青木裕子、石濱泰、今居譲、服部信孝
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] パーキンソン病類縁疾患ペリー症候群ショウジョウバエモデルのシナプスの異常はTDP-43の減少で軽減される2017
- Author(s)
  今居　譲
- Organizer
  ConBio2017
- Invited
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] PINK1-Parkinシグナル伝達に関与する新規分子の解析2017
- Author(s)
  柴佳保里、井下強、青木裕子、石濱泰、今居譲、服部信孝
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-16K15484
[Presentation] ミトコンドリアの機能維持に関与するパーキンソン病原因遺伝子の解析2017
- Author(s)
  今居　譲
- Organizer
  ミトコンドリア機能研究会
- Place of Presentation
  大阪市
- Invited
- Data Source
  KAKENHI-PROJECT-16K15484
[Presentation] 小胞輸送と神経分泌を制御するパーキンソン病関連遺伝子のスクリーニング、ポスター、5-a 高次生命現象・疾患 - 脳・神経系2016
- Author(s)
  崔長旭、井下強、服部信孝、今居譲
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜、横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15H04842
[Presentation] パーキンソン病新規原因遺伝子CHCHD2の機能解析2016
- Author(s)
  山下力、孟　紅蕊、井下強、福嶋佳保里、荒野拓、佐藤栄人、今居譲、服部信孝
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] In vivo evidence for the involvement of phospho-ubiquitin signal.2016
- Author(s)
  Shiba K, Ishikawa K, Takanashi M, Akamatsu W, Imai Y, Hattori N
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2016-07-22
- Data Source
  KAKENHI-PROJECT-26461280
[Presentation] パーキンソン病病態へのリン酸化ユビキチンシグナル関与の証拠、ポスター、5-i 高次生命現象・疾患 - 遺伝性疾患2016
- Author(s)
  柴佳保里、石川景一、高梨雅史、赤松和土、今居譲, 服部信孝
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜、横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15H04842
[Presentation] Parkinson's disease-associated mutations of PLA2G6 alters the membrane dynamics.2016
- Author(s)
  Mori A, Imai Y, Hattori N
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] パーキンソン病原因遺伝子によるシナプス小胞動態制御、ポスター、5-a 高次生命現象・疾患 - 脳・神経系2016
- Author(s)
  井下強、荒野拓、穂坂有加、孟紅蕊、梅崎勇次郎、小杉紗紀子、森本高子、小池正人、Hui-Yun Chang、今居譲、服部信孝
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜、横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15H04842
[Presentation] Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson’s disease.2016
- Author(s)
  Shiba K, Ishikawa K, Inoshita T, Akamatsu W, Hideyuki O, Imai Y, Hattori N
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26461280
[Presentation] 小胞輸送と神経分泌を制御するパーキンソン病関連遺伝子のスクリーニング2016
- Author(s)
  崔　長旭、井下　強、服部　信孝、今居　譲
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] CHCHD2, a Parkinson's-Disease Associated Protein, Regulates the Mitochondrial cristae integrity and function in Drosophila2016
- Author(s)
  Meng H, Yamashita C, Shiba-Fukushima K, Inoshita T, Imai Y, Hattori N
- Organizer
  第39回日本神経学会学術大会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] Synaptic vesicle dynamics are regulated by a subset of Parkinson’s disease genes2016
- Author(s)
  Inoshita T, Cui C, Hattori N, Imai Y
- Organizer
  第39回日本神経学会学術大会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] Synaptic vesicle dynamics are regulated by Parkinson’s disease-associated proteins Vps35 and LRRK22016
- Author(s)
  Inoshita T, Hosaka Y, Imai Y, Hattori N
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸コンベンションホール他、神戸
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-15H04842
[Presentation] In vivo evidence for the involvement of phospho-ubiquitin signal2016
- Author(s)
  Shiba-Fukushima K, Ishikawa K-I, Takanashi M, Akamatsu W, Imai Y, Hattori N
- Organizer
  第39回日本神経学会学術大会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] CHCHD2, a Parkinson's-Disease Associated Protein, Regulates the Mitochondrial cristae integrity and function in Drosophila, Oral O2-G-3-3, Movement Disorders2016
- Author(s)
  Meng H, Yamashita C, Shiba K, Inoshita T, Imai Y, Hattori N.
- Organizer
  The 39th Annual Meeting of the Japan Neuroscience Society
- Place of Presentation
  Yokohama, Yokohama
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-15H04842
[Presentation] Mutations of mitochondrial protein CHCHD2 lead to parkinson’s disease-like phenotypes inDrosophil. ポスター発表2016
- Author(s)
  Meng H, Yamashita C, Shiba-Fukushima K, Inoshita T, Funayama M, Sato S, Imai Y, Hattori N
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸コンベンションホール他、神戸
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-15H04842
[Presentation] パーキンソン病新規原因遺伝子CHCHD2の機能解析2016
- Author(s)
  山下力、孟紅蕊、井下強、福嶋佳保里、荒野拓、佐藤栄人、今居譲、服部信孝.
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸コンベンションホール他、神戸
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-15H04842
[Presentation] .The function of CHCHD2, the novel gene responsible for a familial form of Parkinson's disease, Symposium S1-D-3, Pathogenetic mechanisms underlying Parkinson's disease -On the roles of alpha-synuclein, mitochondria and lysosomes2016
- Author(s)
  Hattori N, Funayama M, Imai Y, Sato S
- Organizer
  The 39th Annual Meeting of the Japan Neuroscience Society
- Place of Presentation
  Pacifico Yokohama, Yokohama
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-15H04842
[Presentation] Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c.2016
- Author(s)
  Meng H, Yamashita C, Shiba-Fukushima K, Inoshita T, Funayama M, Sato S, Imai Y, Hattori N
- Organizer
  第39回日本分子生物学会年会　シンポジウム
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] Parkinson's disease-associated mutations of PLA2G6 alters the membrane dynamics.2016
- Author(s)
  Mori A, Imai Y, Hattori N
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸コンベンションホール他、神戸
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-15H04842
[Presentation] パーキンソン病原因遺伝子によるシナプス小胞動態制御2016
- Author(s)
  井下　強、荒野　拓、穂坂　有加、孟　紅蕊、梅崎　勇次郎、小杉　紗紀子、森本　高子、小池　正人、Hui-Yun Chang、服部　信孝、今居　譲
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] The Loss of Parkinson's Disease-Associated Protein CHCHD2 Affects Mitochondrial Cristae Structure and Destabilizes Cytochrome c, Symposium 2PS9-42016
- Author(s)
  Meng H, Yamashita C, Shiba K, Inoshita T, Funayama M, Sato S, Imai Y, Hattori N.
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜、横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15H04842
[Presentation] Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson's disease2016
- Author(s)
  Shiba-Fukushima K, Ishikawa K-I, Takanashi M, Akamatsu W, Imai Y, Hattori N
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] Regulation of mitochondrial division and mitophagy by syntaxin 17.2015
- Author(s)
  Arasaki K, Sugo M, Hirota N, Dohmae N, Ortiz-Sandoval C, Simmen T, Imai Y, Hattori N, Tagaya M
- Organizer
  Cell Symposia, Multifaceted Mitochondria
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-07-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04842
[Presentation] Mutations of a mitochondrial protein CHCHD2 in Drosophila lead to Parkinson’s disease-like phenotypes.2015
- Author(s)
  Meng H, Yamashita C, Shiba-Fukushima K, Hattori N, Imai Y.
- Organizer
  Cell Symposia, Multifaceted Mitochondria,
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-07-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04842
[Presentation] PINK1-Parkinシグナルによるミトコンドリアの品質管理機構、ワークショップ　フォスタグ技術による神経科学へのアプローチ　- タンパク質リン酸化研究の新潮流 -2015
- Author(s)
  柴　佳保里、今居　譲、服部信孝
- Organizer
  第38回日本分子生物学会年会（BMB2015）
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04842
[Presentation] Parkinson's disease-associated mutations of PLA2G6 alters the membrane dynamics、英語ポスター2015
- Author(s)
  森聡生、王子悠、奥住文美、波田野琢、今居譲、久保紳一郎、服部信孝．
- Organizer
  第56回日本神経学会総会
- Place of Presentation
  朱鷺メッセ、新潟市
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-15H04842
[Presentation] ショウジョウバエ分子遺伝学を利用した遺伝性パーキンソン病へのアプローチワークショップ神経変性疾患の原因を遺伝子レベルからアプローチする2015
- Author(s)
  今居　譲
- Organizer
  第38回日本分子生物学会年会（BMB2015）
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04842
[Presentation] Circadian rhythm analysis in a Drosophila model of Parkinson's syndrome、ポスター(英語)2015
- Author(s)
  穂坂有加、今居譲、服部信孝
- Organizer
  第56回日本神経学会総会
- Place of Presentation
  朱鷺メッセ、新潟市
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-15H04842
[Presentation] PINK1-Parkinシグナルによるミトコンドリアの品質管理機構2015
- Author(s)
  柴　佳保里、今居　譲、服部信孝
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-03
- Invited
- Data Source
  KAKENHI-PUBLICLY-26117727
[Presentation] Regulation of mitochondrial division and mitophagy by syntaxin 17. Cell Symposia, Multifaceted Mitochondria2015
- Author(s)
  Arasaki K, Sugo M, Hirota N, Dohmae N, Ortiz-Sandoval C, Simmen T, Imai Y, Hattori N, Tagaya M
- Organizer
  Cell Symposia
- Place of Presentation
  シカゴ
- Year and Date
  2015-07-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] ショウジョウバエ分子遺伝学を利用した遺伝性パーキンソン病へのアプローチワークショップ神経変性疾患の原因を遺伝子レベルからアプローチする2015
- Author(s)
  今居　譲
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PUBLICLY-26117727
[Presentation] Parkinson's disease-associated proteins Vps35 and LRRK2 regulate synaptic vesicle dynamics, Oral Session2015
- Author(s)
  Inoshita T, Hosaka Y, Imai Y, Hattori N.
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸コンベンションセンター
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-15H04842
[Presentation] Neurodegenerative mechanism of Parkinson’s disease-associated kinase LRRK22015
- Author(s)
  Imai Y
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ（新潟県新潟市）
- Year and Date
  2015-05-22
- Invited
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering2015
- Author(s)
  Shiba-Fukushima K, Arano T, Matsumoto G, Inoshita T, Yoshida S, Ishihama Y, Ryu K-K, Nukina N, Imai Y, Hattori N
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ（新潟県新潟市）
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering2015
- Author(s)
  Shiba-Fukushima K, Arano T, Matsumoto G, Inoshita T, Yoshida S, Ishihama Y, Ryu K-K, Nukina N, Imai Y, Hattori N
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ（新潟県新潟市）
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PUBLICLY-26117727
[Presentation] ショウジョウバエ分子遺伝学を利用した遺伝性パーキンソン病へのアプローチ2015
- Author(s)
  今居　譲
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] Mutations of a mitochondrial protein CHCHD2 in Drosophila lead to Parkinson’s disease-like phenotypes2015
- Author(s)
  Meng H, Yamashita C, Shiba-Fukushima K, Hattori N, Imai Y
- Organizer
  Cell Symposia
- Place of Presentation
  シカゴ
- Year and Date
  2015-07-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] PINK1-Parkinミトコンドリア品質管理機構に関与する分子の探索2014
- Author(s)
  柴佳保里、井下　強、梅崎勇次郎、今居　譲、服部信孝
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場（福岡県・福岡市）
- Year and Date
  2014-05-23
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] PINK1によるParkin機能制御の分子基盤と神経機能への影響2014
- Author(s)
  今居　譲
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場（福岡県・福岡市）
- Year and Date
  2014-05-24
- Data Source
  KAKENHI-PUBLICLY-26117727
[Presentation] PINK1によるリン酸化ポリユビキチン鎖のミトコンドリア上での形成は、Parkinのミトコンドリア局在を促す2014
- Author(s)
  今居　譲
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜）
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PUBLICLY-26117727
[Presentation] PINK1-Parkinミトコンドリア品質管理機構に関与する分子の探索2014
- Author(s)
  柴佳保里、井下　強、梅崎勇次郎、今居　譲、服部信孝
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場（福岡県・福岡市）
- Year and Date
  2014-05-23
- Data Source
  KAKENHI-PUBLICLY-26117727
[Presentation] Mitochondrial quality control by the gene products of early-onset Parkinson's disease2014
- Author(s)
  今居　譲
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜）
- Year and Date
  2014-09-11
- Invited
- Data Source
  KAKENHI-PUBLICLY-26117727
[Presentation] PINK1によるParkin機能制御の分子基盤と神経機能への影響2014
- Author(s)
  今居　譲
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場（福岡県・福岡市）
- Year and Date
  2014-05-24
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] Lysine 63-linked polyubiquitination is dispensable for Parkin-mediated mitophagy2014
- Author(s)
  Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-26461280
[Presentation] Lysine 63-linked polyubiquitination is dispensable for Parkin-mediated mitophagy2014
- Author(s)
  Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜）
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PUBLICLY-26117727
[Presentation] PINK1-Parkinミトコンドリア品質管理機構に関与する分子の探索2014
- Author(s)
  柴佳保里、井下　強、梅崎勇次郎、今居　譲、服部信孝
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡
- Year and Date
  2014-05-23
- Data Source
  KAKENHI-PROJECT-26461280
[Presentation] Mitochondrial quality control by the gene products of early-onset Parkinson's disease2014
- Author(s)
  今居　譲
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜）
- Year and Date
  2014-09-11
- Invited
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] Lysine 63-linked polyubiquitination is dispensable for Parkin-mediated mitophagy2014
- Author(s)
  Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜）
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] PINK1によるリン酸化ポリユビキチン鎖のミトコンドリア上での形成は、Parkinのミトコンドリア局在を促す2014
- Author(s)
  今居　譲
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜）
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-26293070
[Presentation] PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin: an initial step of mitophagy2012
- Author(s)
  Yuzuru Imai
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23790973
[Presentation] 若年性パーキンソン病遺伝子によるミトコンドリア輸送制御2012
- Author(s)
  今居　譲
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790973
[Presentation] PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy2012
- Author(s)
  Yuzuru Imai
- Organizer
  The 17th Takeda Science Foundation Symposium on Bioscience
- Place of Presentation
  吹田
- Data Source
  KAKENHI-PROJECT-23790973
[Presentation] LRRK2による小胞輸送制御とその神経機能に及ぼす影響2012
- Author(s)
  今居　譲
- Organizer
  第6回パーキンソン病・運動障害疾患コングレス
- Place of Presentation
  京都
- Invited
- Data Source
  KAKENHI-PUBLICLY-23110502
[Presentation] LRRK2 Modulates Notch Signaling through the Endosomal pathway2012
- Author(s)
  Yuzuru Imai
- Organizer
  Society for Neuroscience 39th annual meeting
- Place of Presentation
  New Orleans
- Data Source
  KAKENHI-PUBLICLY-23110502
[Presentation] The HECT-type ubiquitin ligase HUWE1 mediates the stability of PINK12011
- Author(s)
  Sawada, T., Kanao, T., Kobayashi, Y., Takahashi, R., Imai, Y.
- Organizer
  3rd Asian and Oceanian Parkinson's Disease and Movement Disorders Congress
- Place of Presentation
  Taipei
- Year and Date
  2011-03-26
- Data Source
  KAKENHI-PROJECT-21790302
[Presentation] モデルショウジョウバエを用いた遺伝性若年性パーキンソン病の研究2011
- Author(s)
  今居譲
- Organizer
  第64回日本自律神経学会総会
- Place of Presentation
  秋田(招待講演)
- Year and Date
  2011-10-28
- Data Source
  KAKENHI-PUBLICLY-23110502
[Presentation] HECT型ユビキチンリガーゼMule/Huwe1によるPINK1安定性の調節2011
- Author(s)
  澤田知世, 金尾智子, 小林芳人, 高橋良輔, 今居譲
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  名古屋
- Year and Date
  2011-05-18
- Data Source
  KAKENHI-PROJECT-21790302
[Presentation] Translational control and stress response in Parkinson's disease2011
- Author(s)
  Imai, Y.
- Organizer
  12th INTERNATIONAL CONGRESS ON AMINO ACIDS, PEPTIDES AND PROTEINS
- Year and Date
  2011-08-01
- Data Source
  KAKENHI-PROJECT-21790302
[Presentation] Translational control and stress response in Parkinson's disease2011
- Author(s)
  Imai Yuzuru
- Organizer
  12th INTERNATIONAL CONGRESS ON AMINO ACIDS, PEPTIDES AND PROTEINS
- Place of Presentation
  北京(招待講演)
- Year and Date
  2011-08-01
- Data Source
  KAKENHI-PROJECT-21790302
[Presentation] Translational control and stress response in Parkinson's disease2011
- Author(s)
  Imai Yuzuru
- Organizer
  12th INTERNATIONAL CONGRESS ON AMINO ACIDS, PEPTIDES AND PROTEINS
- Place of Presentation
  北京(招待講演)
- Year and Date
  2011-08-01
- Data Source
  KAKENHI-PUBLICLY-23110502
[Presentation] Pathogenic mechanisms in familial forms of Parkinson's disease revealed by Drosophila models2011
- Author(s)
  Imai Y.
- Organizer
  The 3rd International Symposium of Neurodegeneration Control Research Center
- Place of Presentation
  ソウル、韓国
- Year and Date
  2011-02-10
- Data Source
  KAKENHI-PROJECT-21790302
[Presentation] モデルショウジョウバエを用いた遺伝性若年性パーキンソン病の研究2011
- Author(s)
  今居　譲
- Organizer
  第64回日本自律神経学会総会(招待講演)
- Place of Presentation
  秋田
- Data Source
  KAKENHI-PROJECT-23790973
[Presentation] The HECT-type ubiquitin ligase Huwe1/Mule mediates the stability of PINK12011
- Author(s)
  澤田知世, 金尾智子, 小林芳人, 高橋良輔, 今居譲
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PROJECT-21790302
[Presentation] Translational control and stress response in Parkinson’s disease2011
- Author(s)
  Imai Yuzuru
- Organizer
  12th INTERNATIONAL CONGRESS ON AMINO ACIDS, PEPTIDES AND PROTEINS(招待講演)
- Place of Presentation
  北京
- Data Source
  KAKENHI-PROJECT-23790973
[Presentation] Pathogenic mechanisms in familial forms of Parkinson's disease revealed by Drosophila models2011
- Author(s)
  Imai, Y.
- Organizer
  "MicroRNAs in Neurodegenerative diseases" The 3rd International Symposium of Neurodegeneration Control Research Center
- Place of Presentation
  Seoul
- Year and Date
  2011-02-10
- Data Source
  KAKENHI-PROJECT-21790302
[Presentation] ショウジョウバエパーキンソン病モデルを用いたLRRK2シグナルの解析2010
- Author(s)
  今居譲
- Organizer
  グローバルCOEセミナー
- Place of Presentation
  京都大学医学研究科
- Year and Date
  2010-03-05
- Data Source
  KAKENHI-PROJECT-21790302
[Presentation] Nitric oxide signal modulates FoxO's activity and alters dopaminergic nueron survival and motor activity in Drosophila2010
- Author(s)
  Kanao, T., Sawada, T., Davies, SA., Moriwaki, Y., Takahashi, R. Imai, Y.
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会口演およびポスター
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21790302
[Presentation] PINK1のユビキチンリガーゼ候補としてのMule/Huwe1の解析2010
- Author(s)
  澤田知世, 金尾智子, 小林芳人, 高橋良輔, 今居譲
- Organizer
  平成22年度Movement Disorder Society Japan学術大会ポスター
- Place of Presentation
  神戸
- Year and Date
  2010-10-09
- Data Source
  KAKENHI-PROJECT-21790302
[Presentation] ショウジョウバエパーキンソン病モデルを用いたLRRK2シグナルの解析2010
- Author(s)
  今居譲
- Organizer
  グローバルCOEセミナー
- Place of Presentation
  京都大学
- Year and Date
  2010-03-05
- Data Source
  KAKENHI-PROJECT-21790302
[Presentation] The Loss of PGAM5 Suppresses the Mitochondrial Degeneration Caused by Inactivation of PINK1 in Drosophila2010
- Author(s)
  Imai Y.
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21790302
[Presentation] Regulation of the PINK1 signaling by a mitochondrial protein PGAM52010
- Author(s)
  Sawada, T., Kanao, T., Kobayashi, Y., Takahashi, R., Imai, Y.
- Organizer
  第33回日本神経科学大会口演
- Place of Presentation
  神戸
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-21790302
[Presentation] The Loss of PGAM5 Suppresses the Mitochondrial Degeneration Caused by Inactivation of PINK1 in Drosophila2010
- Author(s)
  Imai, Y., Kanao, T., Sawada, T., Kobayashi, Y., Moriwaki, Y., Ishida, Y., Takeda, K., Ichijo, H., Lu, B., Takahashi, R.
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会口演およびポスター
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21790302
[Presentation] Identification of Mule as a candidate ubiquitin ligase of PINK12010
- Author(s)
  Sawada, T., Kanao, T., Kobayashi, Y., Takahashi, R. Imai, Y.
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会ポスター
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21790302
[Presentation] LRRK2 phosphorylates FoxO and alters dopaminergic neuron survival in Drosophila2009
- Author(s)
  Kanao T., Venderova, K., Park, DS., Lu, B., Imai, Y.
- Organizer
  第32回日本分子生物学会年会口演およびポスター
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-21790302
[Presentation] Analysis of Pael-R complex components as Parkin substrates2009
- Author(s)
  澤田知世, 今居譲, 服部信孝, 北山滋雄, 高橋良輔
- Organizer
  第32回日本分子生物学会年会ポスター
- Place of Presentation
  横浜
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-21790302
[Presentation] Phosphorylation of FoxO by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila2009
- Author(s)
  今居譲
- Organizer
  日本神経科学大会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-21790302
[Presentation] Parkinの基質としてのPael-R複合体の解析2009
- Author(s)
  澤田知世, 今居譲, 服部信孝, 北山滋雄, 高橋良輔
- Organizer
  第32回日本神経科学大会口演
- Place of Presentation
  名古屋
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-21790302
[Presentation] Phosphorylation of FoxO by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila2009
- Author(s)
  Imai, Y., Kanao T., Venderova, K., Park, DS., Lu, B.
- Organizer
  第32回日本神経科学大会口演
- Place of Presentation
  名古屋
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-21790302
[Presentation] Analysis of sleep-wake rhythms in aged and Parkinson’s disease model flies.
- Author(s)
  Umezaki Y, Yoshii T, Helfrich-Förster C, Tomioka K, Hattori N, Imai Y
- Organizer
  The 2014 Meeting of the Society for Research on Biological Rhythms.
- Place of Presentation
  Montana
- Year and Date
  2014-06-14 – 2014-06-18
- Data Source
  KAKENHI-PROJECT-26293070

1. INOSHITA Tsuyoshi (20601206)

# of Collaborated Projects: 7 results

# of Collaborated Products: 30 results
2. SHIBA Kahori (30468582)

# of Collaborated Projects: 6 results

# of Collaborated Products: 36 results
3. HATTORI Nobutaka (80218510)

# of Collaborated Projects: 3 results

# of Collaborated Products: 50 results
4. ARANO Taku (80750091)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
5. EJIMA Aki (00548571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MENG Hongrui (90736498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
7. ISHIHAMA Yasushi (30439244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. TAKAHASHI Ryosuke (90216771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
9. SUZUKI Yasuyuki (40321773)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. OHBA Yusuke (30333503)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. FUNAYAMA Manabu (70468578)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
12. HATANO Taku (60338390)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. AKAMATSU Wado (60338184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. 佐藤栄人 (00445537)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
15. INOMATA Megumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 森聡生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 石川景一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 緒方洵

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 李元哲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 大塚俊之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 井上弘樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 佐藤美由紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 西岡健弥

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 池田彩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 斉木臣二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Imai Yuzuru 今居 譲

IMAI Yuzuru 今居 譲

今居 讓 イマイ ユズル

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanism of alpha-Synuclein aggregation by lipid and mitochondrial alterationPrincipal Investigator

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Analysis of propagation risk factors for food-derived alpha-Synuclein seedsPrincipal Investigator

Principal Investigator

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Elucidation of intracellular environmental factors that produce a risk for alpha-Synuclein seedingPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Exploration of Parkinson disease-specific pathological backgroundPrincipal Investigator

Principal Investigator

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Drug screening to improve mitochondrial functionsPrincipal Investigator

Principal Investigator

Project Period (FY)

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Analysis of lipid composition in hereditary Parkinson's Disease and the association with the pathology

Principal Investigator

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Research Institution

ミトコンドリアの共生を規定する、排除と維持の監視メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A study on the common pathogenesis of Parkinson's disease as a mitochondrial diseasePrincipal Investigator

Principal Investigator

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Research Institution

Elucidation of the mechanism of mitochondrial maintenance by Parkinson's disease gene products

Principal Investigator

Project Period (FY)

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Research Institution

in vivo live imaging for sex pheromone information presentation neural mechanism in Drosophila olfaction

Principal Investigator

Project Period (FY)

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Research Institution

晩発性パーキンソン病原因遺伝子産物タンパク質ネットワークの包括的解析Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Analysis of the molecular mechanism by which the genes for early‐onset parkinson's disease regulate mitochondrial maintenancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a multiphase screening method for genes responsible for age-dependent neurodegenerative disordersPrincipal Investigator

Principal Investigator

Imai Yuzuru 今居譲

IMAI Yuzuru 今居譲

今居讓イマイユズル

[Book] 認知症　発症前治療のために解明すべき分子病態は何か？ -劣性遺伝性若年性パーキンソン病(AR-JP)の臨床、病理、分子遺伝学2017

[Book] 週刊　医学のあゆみ　ミトコンドリア研究 UPDATE2017

[Book] 別冊　医学のあゆみ　ミトコンドリア研究 UPDATE2017