TAKANO Tatsuya 高野達哉

Researcher Number	40124995
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2007: Teikyo University, 薬学部, 教授 1986 – 2005: 帝京大学, 薬学部, 教授 1986: 帝京大, 薬学部, 教授
Review Section/Research Field	Principal Investigator Biological pharmacy / Biological pharmacy Except Principal Investigator Biological pharmacy / 代謝生物化学 / 医薬分子機能学
Keywords	Principal Investigator 動脈硬化 / 過酸化脂質 / 泡沫細胞 / マクロファージ / 内皮細胞 / モノクローナル抗体 / atherosclerosis / リポタンパク質 / コレステロール / 酸化リポタンパク質 … More / 平滑筋細胞 / oxidized LDL / LCAT / Monoclonal antibody / Macrophage / 腎疾患 / 体外診断薬 / 高脂血症 / SREBP / foam cell / monoclonal antibody / lipoprotein / 9CHO-PC / 心筋梗塞 / cholesterol / extracellular matrix / vitronectin / glycoprotein / モノクロナル抗体 / コレステロール・エステル / エラスチン / 人工血管 / アポトーシス / コラ-ゲン / フィブロネクチン / 透過 / 血管壁 / Atherogenesis / Hyperlipidemia / Foam cell / Necrosis / Apoptosis / 脂質球 / リン脂質 / 256C抗体 / 動脈硬化進展 / ネクローシス / Atherectomy / Macorphage / Myocardial infarction / モリクローナル抗体 / ELISA / 免疫組織化学 / oxidized PC / 酸化燐脂質 / 酸化LDL / Phosphatidylcholine / Lipoprotein / Oxidized LDL / 賢疾患 / リソソーム / フォスファチジルコリン / Atherosclerosis / Transcription / LDL Receptor / Cholesterol / コレステロール合成 / HMGCoA還元酵素 / LDL受容体転写因子 / ALLN / 転写調節 / SRE / HMGCoA合成酵素 / 転写因子 / LDL受容体 / in vitro diagnosis / oxidized phosphatidylcholine / lipid peroxide / モノクロナール抗体 / 低比重リポタンパク質 / 診断薬 / ホスファチジルコリン / arterial wall / embryo / 器官培養 / 血管新生 / 発生学 / 大動脈 / 発生 / cDNA / コレステロ-ル / シアル酸 / ピトロネクチン / 細胞外マトリックス / ビトロネクチン / 糖蛋白質 / platelets / formic acid / fibronectin / fibrinogen / endothelial cells / collagen / biomimetic prosthesis / テフロン / ダクロン / 器官形成 / 蟻酸 / Lysosome / Endothelial Cell / Transcytosis / Angiotensin / フルオレッセインデキストラン / リポタン白質 / リポ蛋白 / ニワトリ / アホトーシス / 酸化リホタンバク質 / 粥状動脈硬化 / 内皮細胞剥離 / フィブリノ-ゲン / プロスタサイクリン / 血小板 / 極性 / 受容体 / アンジオテンシン … More Except Principal Investigator 血管新生 / 血管内皮細胞 / 血管内皮細胞成長因子 / 血管中膜平滑筋細胞 / 小器官 / 細胞応答 / 整合性 / 薬物刺激 / EDRF / エンドセリン / 細胞接着分子 / C_<12>E_9 / Triton-X-114 / H^+-ATPase / ポンプ / プロトン / Lysosome / リソゾーム / 肝臓 / ラット / 中膜平滑筋細胞 / 受容体リガンド / 受容体 / 医薬創製 / エンドサイトーシス / エキソサイトーシス / 蛋白質輸送 / リソソーム / 小胞輸送 / 蛋白質膜透過 / ゴルジ装置 / 小胞体 / 蛋白質選別輸送 Less

Molecular mechanism of the progression of Atherosclerosis triggered by degradation of form cellsPrincipal Investigator
- Principal Investigator
  
  YAMAGUCHI Shinj, 高野達哉
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Teikyo University
Foam cell rupture may involve in the development of atheromaPrincipal Investigator
- Principal Investigator
  
  TATSUYA Takano
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Teikyo University
Oxidized lipoproteins released from atherosclerotic lesionsPrincipal Investigator
- Principal Investigator
  
  TAKANO Tatsuya
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Teikyo University
Novel diagnosis of oxidized LDL in serum using monoclonal antibodyPrincipal Investigator
- Principal Investigator
  
  TAKANO Tatsuya
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Teikyo University
Metabolism of Oxidized Low Density Lipoprotein by Lecithin-Colesterol AcyltransfersePrincipal Investigator
- Principal Investigator
  
  TAKANO Tatsuya
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Teikyo University
Transcriptional regulation of intracellular cholesterol metabolismPrincipal Investigator
- Principal Investigator
  
  TAKANO Tatsuya
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Teikyo University
Monoclonal Antibody Recognizing Peroxidized Lipoproteins Accumulated in Atherosclerotic Lesion.Principal Investigator
- Principal Investigator
  
  TAKANO Tatsuya
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Teikyo University
血管病変の成因究明を指向した血管内皮細胞の特性と機能に関する総合的研究
- Principal Investigator
  
  室田誠逸
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University
医薬創製理論構築のための基盤的研究-探索・設計・評価
- Principal Investigator
  
  広部雅昭
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  The University of Tokyo
小胞体経路の蛋白質選別輸送の分子機構
- Principal Investigator
  
  大村恒雄
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
Attempts for contruction of arterial wall with medial smooth muscle cells in vitro -An approach foam developmental biology-Principal Investigator
- Principal Investigator
  
  TAKANO Tatsuya
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Teikyo University
血管病変の成因究明を指向した血管内皮細胞の特性と機能に関する総合的研究
- Principal Investigator
  
  室田誠逸
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University
A novel monoclonal antibody recognizing extracellular space of the atherosclerotic lesions in WHHL rabbits.Principal Investigator
- Principal Investigator
  
  TAKANO Tatsuya
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Teikyo University
培養内皮細胞剥離モデルによる血小板粘着機構の解析Principal Investigator
- Principal Investigator
  
  高野達哉
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Teikyo University
培養内皮細胞による生理活性物質の透過制御機構の解析Principal Investigator
- Principal Investigator
  
  高野達哉
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Teikyo University
Preparation of biomimetic prosthesis prepared from cultured smooth muscle cells and endothelial cells.Principal Investigator
- Principal Investigator
  
  TAKANO Tatsuya
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Teikyo University
細胞培養法による血管系の分化機構の研究
- Principal Investigator
  
  室田誠逸
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Tokyo Medical and Dental University
培養内皮細胞を用いたアンジオテンシン透過機構の解析Principal Investigator
- Principal Investigator
  
  高野達哉
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Teikyo University
細胞培養による血管系の分化機構の研究
- Principal Investigator
  
  室田誠逸
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Tokyo Medical and Dental University
薬物応答による細胞整合性の分子論的解伏とその展開
- Principal Investigator
  
  野島庄七
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Teikyo University
培養血管内皮細胞を用いた物質輸送機構の解析Principal Investigator
- Principal Investigator
  
  高野達哉
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Teikyo University
Lysosome H^+-ATPaseの分子構築に関する生化学的・免疫化学的研究
- Principal Investigator
  
  大熊勝治
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  代謝生物化学
- Research Institution
  Teikyo University
細胞培養法による血管系の分化機構の研究
- Principal Investigator
  
  室田誠逸
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Tokyo Medical and Dental University
薬物応答による細胞内整合性の分子論的解析とその展開
- Principal Investigator
  
  野島庄七
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Teikyo University
動脈硬化巣に蓄積する過酸化脂質とその意義Principal Investigator
- Principal Investigator
  
  高野達哉
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Teikyo University

All 2009 2008 2007 2006 2004 2003 2002

All Journal Article Presentation Book

[Book] New Frontier in Lifestyle-Related Diseases. Regulation of Intracellular Lipid Storage and Adipose Differentiation-Related Protein (ADRP)2008
- Author(s)
  Itabe,H., Masuda, Y, Sasabe, N., Kitazato, K., Arai, H., Takano, T.
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-19590079
[Journal Article] Transient increase in plasma oxidized LDL during the progression of atherosclerosis in apolipoprotein E knockout mice2009
- Author(s)
  Kato, R.,Mori, C.,Kitazato, K.,Arata, S.,Obama, T.,Mori, M.,Takahashi, K.,Aiuchi, T.,Takano, T.,Itabe H.
- Journal Title
  
  Arterioseler Thromb Vase Bid 29
  
  Pages: 33-39
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590079
[Journal Article] Gene expression profile in cerebrum in the filial ial imprinting of domestic chick (Gallus gallus donlesticus)2008
- Author(s)
  Yamaguchi, S., Fujii-Taira, I., Katagiri, S., Izawa, E., Fujimoto, Y, Takeuchi, H., Takano, T., Matsushima, T. and Homma, K.J.
- Journal Title
  
  Brain Res. Bull 76
  
  Pages: 275-281
- Data Source
  KAKENHI-PROJECT-19590079
[Journal Article] Up-regulation of microtubule-associated protein 2 accompanying the filial imprinting of domestic chick (Gallus galltts domesticus)2008
- Author(s)
  Yamaguchi, S., Fujii-Taira, I., Murakami, A., Hirose, N., Aoki, N., Izawa, E., Fujimoto, Y., Takano, T., Matsushima, T., and Homma, K.J.
- Journal Title
  
  Brain Res. Bull 76
  
  Pages: 282-288
- Data Source
  KAKENHI-PROJECT-19590079
[Journal Article] Involvement of long chain acyl-CoA synthetase in local synthesis of neutral lipids in cytoplasmic lipid droplets in human hepatocyte HuH72007
- Author(s)
  Fujimoto, Y., Itabe, H., Kinoshita, T., Homma, K. J., Onoduka, J., Mori, M., Yamaguchi, S., Makita, M., Higashi, Y., Yamashita, A. and Takano, T.
- Journal Title
  
  J Lipid Res. 48
  
  Pages: 1280-1292
- Data Source
  KAKENHI-PROJECT-19590079
[Journal Article] In viva gene transfer into newly-hatched chick brain by electroporation2007
- Author(s)
  Yamaguchi, S., Katagiri, S., Hirose, N., Fujimoto, Y., Mori, M., Fujii-Taira, I., Takano, T., Matsushima, T. and Homma, K. J.
- Journal Title
  
  Neuroreport 18
  
  Pages: 735-739
- Data Source
  KAKENHI-PROJECT-19590079
[Journal Article] ADRP/adipophilin is degraded through the proteasome-dependent pathway during regression of lipid-storing cells2006
- Author(s)
  Y.Masuda, T.Takano et al.
- Journal Title
  
  J.Lipid Res. 47
  
  Pages: 87-98
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370751
[Journal Article] Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH72004
- Author(s)
  Y.Fujimoto, T.Takano et al.
- Journal Title
  
  Bioch.Bioph.Acta. 1644
  
  Pages: 47-59
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370751
[Journal Article] Serum high-density lipoprotein cholesterol levels modify the association between plasma levels of oxidatively modified low-density lipoprotein and coronary artery disease in men2004
- Author(s)
  B.Zhang, T.Takano et al.
- Journal Title
  
  Metabolism 53
  
  Pages: 423-429
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370751
[Journal Article] Transmembrane lipid transfer is crucial for providing neutral lipids during very low density lipoprotein assenbly in endoplasmic reticulum2003
- Author(s)
  Y.Higashi, T.Takano et al.
- Journal Title
  
  J.Biol.Chem. 278
  
  Pages: 21450-21458
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370751
[Journal Article] Minimally modified LDL is an oxidized LDL enriched with oxidized phosphatidylcholine2003
- Author(s)
  H.Itabe, T.Takano et al.
- Journal Title
  
  J.Biochemistry 134
  
  Pages: 459-465
- NAID
  50000316565
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370751
[Journal Article] Distribution of microsomal triglyceride transfer protein within sub-endoplasmic reticulum regions in human hepatoma cells.2002
- Author(s)
  Y.Higashi, T.Takano et al.
- Journal Title
  
  Bioch.Bioph.Acta 1581
  
  Pages: 127-136
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370751
[Presentation] RNAiによるニワトリヒナ大脳での特異的遺伝子抑圧系の確立2008
- Author(s)
  片桐幸子、広瀬直樹、山口真二、平郁子、藤本康之、高野達哉、松島俊也、本間光一
- Organizer
  日本薬学会128回大会
- Data Source
  KAKENHI-PROJECT-19590079
[Presentation] 鳥類の大脳神経細胞選択的なin vivo遺伝子導入法の確立2007
- Author(s)
  廣瀬直樹、片桐幸子、山口真二、藤本康之、松島俊也、高野達哉、本間光一
- Organizer
  日本神経科学会30回大会
- Data Source
  KAKENHI-PROJECT-19590079
[Presentation] 脂肪滴アシルCoA合成酵素2007
- Author(s)
  藤本康之、板部洋之、木下哲昭、本間光一、山口真二、小野塚潤、山下純、前田正知、高野達哉
- Organizer
  日本生化学会80回大会
- Data Source
  KAKENHI-PROJECT-19590079
[Presentation] In vivoエレクトロボレーション法による鳥類生後脳における神経細胞選択的遺伝子導入2007
- Author(s)
  片桐幸子、廣瀬直樹、山口真二、藤本康之、松島俊也、高野達哉、本間光一
- Organizer
  遺伝子・デリバリー研究会第7回シンポジウム
- Data Source
  KAKENHI-PROJECT-19590079

1. MORI Masahiro (00230079)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
2. IMANAKA Tuneo (50119559)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
3. ITABE Hiroyuki (30203079)

# of Collaborated Projects: 8 results

# of Collaborated Products: 1 results
4. MINEO Chieko (00190710)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
5. SATO Ryuichiro (50187259)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
6. YAGYU Yasuko (60211611)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
7. 室田誠逸 (50072989)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
8. EYA Seiji (20221814)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
9. FUJIMOTO Yasuyuki (60317724)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
10. HIGASHI Yusuke (60286979)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
11. HONMA Koichi (90251438)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
12. 高久史磨 (40048955)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
13. 江橋節郎 (10009863)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
14. 吉田洋二 (10008237)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
15. 大熊勝治 (10119563)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
16. YAMAGUCHI Shinj (60398740)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
17. 赤松穣 (00072900)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
18. 宮坂昌之 (50064613)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
19. 丸山征郎 (20082282)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
20. 藤原敬己 (10190092)

# of Collaborated Projects: 2 results

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21. 沼野藤夫 (40013958)

# of Collaborated Projects: 2 results

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22. 中尾純子 (10150880)

# of Collaborated Projects: 2 results

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23. 野島庄七 (70090470)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
24. 石橋貞彦 (90012616)

# of Collaborated Projects: 2 results

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25. 大場義樹 (10012634)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
26. 山科郁男 (70025675)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
27. 毛利裕臣 (30182158)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
28. FURUKAWA Kin'ichi (80074508)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 大村恒雄 (80029933)

# of Collaborated Projects: 1 results

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30. 三原勝芳 (40029963)

# of Collaborated Projects: 1 results

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31. 姫野勝 (50037602)

# of Collaborated Projects: 1 results

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32. 中野明彦 (90142140)

# of Collaborated Projects: 1 results

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33. 勝沼信彦 (50035375)

# of Collaborated Projects: 1 results

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34. 池原征夫 (70037612)

# of Collaborated Projects: 1 results

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35. 田代裕 (40077558)

# of Collaborated Projects: 1 results

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36. 大西俊一 (00025272)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 広部雅昭 (20012594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 板井昭子 (60012647)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 柴崎正勝 (30112767)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 野村靖幸 (00034041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. 北川勲 (20028830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. KIMURA Junji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. 松田譲

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TAKANO Tatsuya 高野 達哉

Research Projects

Research Products

Co-Researchers

Molecular mechanism of the progression of Atherosclerosis triggered by degradation of form cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Foam cell rupture may involve in the development of atheromaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Oxidized lipoproteins released from atherosclerotic lesionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel diagnosis of oxidized LDL in serum using monoclonal antibodyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Metabolism of Oxidized Low Density Lipoprotein by Lecithin-Colesterol AcyltransfersePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Transcriptional regulation of intracellular cholesterol metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Monoclonal Antibody Recognizing Peroxidized Lipoproteins Accumulated in Atherosclerotic Lesion.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

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Attempts for contruction of arterial wall with medial smooth muscle cells in vitro -An approach foam developmental biology-Principal Investigator

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A novel monoclonal antibody recognizing extracellular space of the atherosclerotic lesions in WHHL rabbits.Principal Investigator

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培養内皮細胞剥離モデルによる血小板粘着機構の解析Principal Investigator

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TAKANO Tatsuya 高野達哉