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SAKAI RYUICHI  堺 隆一

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堺 隆一  サカイ リュウイチ

SAKAI Ryuichi  堺 隆一

SAKAI Ryu-ichi  堺 隆一

境 隆一  サカイ リュウイチ

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Researcher Number 40215603
Other IDs
Affiliation (Current) 2025: 北里大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2015 – 2023: 北里大学, 医学部, 教授
2011 – 2014: 独立行政法人国立がん研究センター, 研究所, 分野長
2009: National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, 研究所・細胞増殖因子研究部, 部長
2009: National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, 細胞増殖因子研究部, 部長
2005 – 2008: 国立がんセンター(研究所及び東病院臨床開発センター), 細胞増殖因子研究部, 部長 … More
2004: 国立がんセンター(研究所), 細胞増殖因子研究部, 部長
2002 – 2003: 国立がんセンター研究所, 細胞増殖因子研究部, 部長
2002: NCCRI, Growth Factor Division, Chief, 研究所・細胞増殖因子研究部, 部長
1999 – 2001: 国立がんセンター, 研究所・ウイルス部, 室長
1999 – 2001: 国立がんセンター研究所, ウイルス部, 室長
1999: Nat'l Cancer Ctr, Virol. Glyocobiol., Sec. head, ウイルス部, 室長
1991 – 1995: 自治医科大学, 医学部, 助手
1990: 東京大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Biological Sciences / Basic Section 50010:Tumor biology-related / Tumor biology / General medical chemistry / Neuroscience in general / Tumor biology / Biological Sciences
Except Principal Investigator
Hematology / Basic Section 52050:Embryonic medicine and pediatrics-related / 広領域 / Experimental pathology
Keywords
Principal Investigator
チロシンキナーゼ / チロシンリン酸化 / 神経芽腫 / Src / ALK / 細胞運動能 / RNAi / スキルス胃がん / ドッキング蛋白質 / SH3 … More / 細胞・組織 / 癌 / Flotillin-1 / 間質線維芽細胞 / p130Cas / Srcキナーゼ / Srcファミリーキナーゼ / 神経芽細胞種 / Shcファミリー蛋白質 / 腫瘍転移 / Srcファミリー / パキシリン / 蛋白質リン酸化 / Cas蛋白質 / Fyn / v-Crk / SH2 / PTP-RZ / ALKキナーゼ / チロシンホスファターゼ / Alk / キナーゼ阻害薬 / キナーゼ阻害剤 / 細胞増殖能 / dasatinib / 微小環境 / Dasatinib / CAF / がん間質相互作用 / 細胞間接着 / 癌微小環境 / 癌間質相互作用 / ファージ抗体 / gene amplification / metastasis / tyrosine kinases / Src family kinases / docking protein / neuroblastoma / ノックアウトマウス / 神経神経芽胞腫 / 遺伝子増幅 / SHP2 / ALK / 薬剤感受性 / 分子標的治療薬 / Shp2 / Flotillin / SHP2 / 転移能 / Anaplastic Lymphoma Kinase(ALK / エンドサイトーシス / 受容体チロシンキナーゼ / リン酸化蛋白質 / 質量分析 / シグナル伝達 / 共培養 / 細胞外基質 / がん浸潤 / 腹膜播種 / 浸潤 / リン酸化 / MET / スキルス胃癌 / 転移・浸潤能 / ShcC / paxillin / ephrin-B1 / pl30Cas / 細胞接着 / Cortactin / 腸間膜播種 / 運動能 / 酸化ストレス / Ossa / CDCP1 / 足場非依存性 / 転移・浸潤 / 神経芽細胞腫 / コルタクチン / メラノーマ / 腫瘍転移能 / 転移脳 / 神経芽種 / ドッキング分子 / がん遺伝子 / 形質転換 / SHZ / p-130^<cas> / インテグリン / Fak / P130^<cas> / p130 / Crk … More
Except Principal Investigator
ガングリオシドGD3合成酵素 / ガングリオシドGM3合成酵素 / シアリルモチーフ / II型膜蛋白質 / cDNAクローニング / シアル酸転移酵素-1 / 遺伝子ノックアウト細胞 / N結合型糖鎖 / GM3合成酵素欠損マウス / シアル酸転移酵素 / サイトカイン / チロシンキナーゼ / 転写因子 / 転写調節 / cDNA Cloning / ゲノム構造 / ガングリオシドGM3 / 5'-RACE法 / PCR / CD34 / C3H10T1 / 特異的アミノ酸置換 / シリアルモチーフ / 5`-RACE法 / 遺伝子治療 / アポトーシス / 自殺遺伝子 / polycomb / ChIPseq / transcriptome / neuroblastoma / MYCN / nural crest cell / 網羅的解析 / エピゲノム / 網羅的ノックアウト / Neural Crest Cell / テロメア異常 / 新規エピゲノム治療開発 / ヒストン修飾 / ゲノムメチル化 / ポリコーム / ゲノム編集 / NCC / iPS / 神経芽腫 / Cis Element / Three Dimesional Structure / Promoter Region / Gene Kockout / Genomic Structure / Ganglioside GM3 Synthase / Sialoglycosphingolipids / 遺伝子改変 / シアリルモティーフ / プロモーター活性 / Sp1結合部位 / TATA・CAAT配列 / ルシフェラーゼ活性 / シス因子 / 酵素蛋白立体構造 / プロモーター領域 / 遺伝子ノックアウト / シアロスフィンゴ糖脂質 / Extracellular Matrix Glycoprotein / Tenascin / Sialocholesterol / Genomic Structure Analysis / Ganglioside GM3 synthase / Synthetic Sialoglycolipids / Gangliosides / 合成シアロ糖化合物 / 分化誘導・増殖抑制 / ヒト骨髄性白血病 / 光学異性体β-アノマー / シアロジグリセリド / ガングリオシド類縁体 / 白血病分化誘導 / ガングリオシドGM3糖鎖ポリマー / ヒトLARGE遺伝子 / アミノCTH合成酵素 / シアル酸転移酵素遺伝子 / 細胞外マトリックス糖蛋白 / テネイシン / シアロコレステロール / ゲノム構造解析 / 脂質性シアロ糖化合物 / ガングリオシド / tyrosine phosphatase / チロシレフォスファターゼ / チロシンフォスファターゼ / チロシンファスファターゼ / Hematopoiesis-supporting ability / Differentiation induction / 2 cell / Preadipocyte / Stromal cell / 造血支持能 / 分化誘導 / 2細胞 / 前脂肪細胞 / ストローマ細胞 / Anti-sense / Protein-tyrosine kinase / レトロウィルス / アンチセンス / transcription factor / ets oncogene / differentiation / 顆粒球単球 / 細胞分化 / ets癌遺伝子 / 血球分化 / 遺伝子発現 / マウスホモローグcDNA / G-CSF / エストロゲン受容体 / Fas / トランスジェニックマウス / abl> / p210^<bcr / Ph^1染色体 / ストロース細胞 / レトロウイルスベクター / 遺伝子導入 / 造血幹細胞 / インターロイキン5 / 成人T細胞性白血病 / ストレス蛋白質 / レドックス / マウスB16メラトマ細胞 / 血管新生 / 転移能 / 血小板由来血管内皮細胞増殖因子 / SSCP法 / RTーPCR法 / p53遺伝子 / ABL遺伝子 / ras遺伝子 / 白血病 Less
  • Research Projects

    (31 results)
  • Research Products

    (168 results)
  • Co-Researchers

    (37 People)
  •  Analysis of reversible oncogenic signals in the pregression of neuroblastomaPrincipal Investigator

    • Principal Investigator
      堺 隆一
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Kitasato University
  •  Development of epigenome therapy for neuroblastoma by iPS-derived tumor model and genome editing

    • Principal Investigator
      Kamijo Takehiko
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Research Institute for Clinical Oncology Saitama Cancer Center
  •  Role of Src family kinases in the Drug Resistance and Progression of NeuroblastomaPrincipal Investigator

    • Principal Investigator
      Ryuichi Sakai
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Kitasato University
  •  Mechanistic analysis of cooperative invasion between cancer cells and stromal fibroblastsPrincipal Investigator

    • Principal Investigator
      Sakai Ryuichi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Tumor biology
    • Research Institution
      Kitasato University
  •  Biological roles of ALK-binding molecules in neuroblastomaPrincipal Investigator

    • Principal Investigator
      Sakai Ryuichi
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Tumor biology
    • Research Institution
      Kitasato University
      National Cancer Center Japan
  •  腹膜播種におけるがんと腹膜との相互作用Principal Investigator

    • Principal Investigator
      堺 隆一
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      National Cancer Center Japan
  •  Analysis of mediators of ALK signaling activated in neuroblastomaPrincipal Investigator

    • Principal Investigator
      SAKAI RYUICHI
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Tumor biology
    • Research Institution
      National Center of Neurology and Psychiatry
  •  Regulation of adhesion and migration of cancer cells by tyrosine kinase signalingPrincipal Investigator

    • Principal Investigator
      SAKAI Ryuichi
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  チロシンキナーゼ基質分子による腫瘍転移・浸潤の制御Principal Investigator

    • Principal Investigator
      堺 隆一
    • Project Period (FY)
      2001 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  Roles of ShcB/ShcC Docking Proteins in Neural Stem Cells and Neuronal TumorsPrincipal Investigator

    • Principal Investigator
      SAKAI Ryuichi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neuroscience in general
    • Research Institution
      National Cancer Center Research Institute
  •  がん特異的リン酸化基質Casによる癌化・転移の制御Principal Investigator

    • Principal Investigator
      堺 隆一
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  制癌の標的分子としての糖脂質糖鎖遺伝子(ガングリオシドGM3合成酵素遺伝子)

    • Principal Investigator
      SAITO Masaki
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  制癌の標的分子としての糖脂質糖鎖遺伝子(ガングリオシドGM3合成酵素遺伝子)

    • Principal Investigator
      齋藤 政樹
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  Expression Mechanism and Its Medical Application of Ganglioside GM3 Synthase Gene Which Is Relevantly Related With Growth and Differentiation of Hematopoietic Cells

    • Principal Investigator
      SAITO Masaki
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      National Cancer Center Research Institute
  •  Exploitation on Biological Activities of Sialoglycosphingolipids and Their Synthetic Family Compounds (Neoglycollipids)

    • Principal Investigator
      SAITO Masaki
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      広領域
    • Research Institution
      National Cancer Center Research Institute
      Hokkaido University
  •  造血幹細胞への遺伝子導入のためのレトロウイルスベクター産生システムの改良

    • Principal Investigator
      OZAWA Keiya
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Jichi Medical University
  •  トランスジェニックマウスを用いたp210^<bcr/abl>の機能解析

    • Principal Investigator
      本田 浩章
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Jichi Medical University
  •  細胞接着・転移におけるCas/Fakの相互作用Principal Investigator

    • Principal Investigator
      堺 隆一
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Jichi Medical University
  •  サイトカイン補充遺伝子療法のための自殺遺伝子を介した細胞レベルでの調節法の開発

    • Principal Investigator
      小澤 敬也
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Jichi Medical University
  •  細胞がん化におけるP130^<cas>の役割Principal Investigator

    • Principal Investigator
      堺 隆一
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Jichi Medical University
  •  Anolysis of a novel protein-tyrosine phosphatase in hemotopoietic system

    • Principal Investigator
      HONDA Hiroaki
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      UNIVERSITY OF TOKYO
      Jichi Medical University
  •  造血幹細胞におけるTecチロシンキナーゼの解析

    • Principal Investigator
      MANO Hiroyuki
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Jichi Medical University
  •  Tecチロシンキナーゼを介する細胞増殖機構

    • Principal Investigator
      間野 博行
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Jichi Medical University
  •  Crk結合リン酸化蛋白質p130の機能解析Principal Investigator

    • Principal Investigator
      堺 隆一
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      General medical chemistry
    • Research Institution
      Jichi Medical University
  •  Molecular study of hematopoiesis-supporting ability of C3H10T1/2 mouse embryo fibroblasts

    • Principal Investigator
      OZAWA Keiya
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Jichi Medical School
  •  レドックス蛋白質の機能解析および癌診断への応用

    • Principal Investigator
      NISHIDA Junji
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Jichi Medical University
  •  成人T細胞性白血病細胞に特異的な転写機構の解明と癌化との関連

    • Principal Investigator
      西田 淳二
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Jichi Medical University
  •  A novel gene therapy against human leukemias : suppression of protein-tyrosine kinase activities

    • Principal Investigator
      MANO Hiroyuki
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Jichi Medical School
      The University of Tokyo
  •  Involvement of ets oncogene family in chromosomal translocation and hemopoietic cell dofferentiation into granulocyte/macrophage lineage

    • Principal Investigator
      NISHIDA Junji
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Jichi Medical School
  •  ヒト白血病の遺伝子診断

    • Principal Investigator
      HIRAI Hisamaru
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  マウスB16メラノ-マ細胞株の転移能に対する血小板由来血管内皮細胞増殖因子の作用

    • Principal Investigator
      平井 久丸
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      The University of Tokyo

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Other

  • [Journal Article] Endocytic vesicles act as vehicles for glucose uptake in response to growth factor stimulation2024

    • Author(s)
      Tsutsumi Ryouhei、Ueberheide Beatrix、Liang Feng-Xia、Neel Benjamin G.、Sakai Ryuichi、Saito Yoshiro
    • Journal Title

      Nature Communications

      Volume: 15 Issue: 1 Pages: 1-15

    • DOI

      10.1038/s41467-024-46971-9

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07105, KAKENHI-PROJECT-20K06633
  • [Journal Article] C9orf10/Ossa regulates the bone metastasis of established lung adenocarcinoma cell subline <scp>H322L‐BO4</scp> in a mouse model2024

    • Author(s)
      Uekita Takamasa、Yagi Reiko、Ichimura Tohru、Sakai Ryuichi
    • Journal Title

      Genes to Cells

      Volume: 29 Issue: 4 Pages: 290-300

    • DOI

      10.1111/gtc.13103

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07105, KAKENHI-PROJECT-21K05322, KAKENHI-PROJECT-21K07165
  • [Journal Article] Polycomb group protein BMI1 protects neuroblastoma cells against DNA damage-induced apoptotic cell death2023

    • Author(s)
      Akita Nobuhiro、Okada Ryu、Mukae Kyosuke、Sugino Ryuichi P.、Takenobu Hisanori、Chikaraishi Koji、Ochiai Hidemasa、Yamaguchi Yohko、Ohira Miki、Koseki Haruhiko、Kamijo Takehiko
    • Journal Title

      Experimental Cell Research

      Volume: 422 Issue: 1 Pages: 113412-113412

    • DOI

      10.1016/j.yexcr.2022.113412

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08269, KAKENHI-PROJECT-22K15517, KAKENHI-PLANNED-19H05745, KAKENHI-PROJECT-19H03625
  • [Journal Article] Transferrin receptor 1 promotes the fibroblast growth factor receptor-mediated oncogenic potential of diffused-type gastric cancer2022

    • Author(s)
      Shirakihara Takuya、Yamaguchi Hideki、Kondo Tadashi、Yashiro Masakazu、Sakai Ryuichi
    • Journal Title

      Oncogene

      Volume: 41 Issue: 18 Pages: 2587-2596

    • DOI

      10.1038/s41388-022-02270-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07242, KAKENHI-PROJECT-17K08648, KAKENHI-PROJECT-21K07105
  • [Journal Article] Integrin α5 mediates cancer cell-fibroblast adhesion and peritoneal dissemination of diffuse-type gastric carcinoma2022

    • Author(s)
      Miyamoto Shingo、Nagano Yoshiko、Miyazaki Makoto、Nagamura Yuko、Sasaki Kazuki、Kawamura Takeshi、Yanagihara Kazuyoshi、Imai Toshio、Ohki Rieko、Yashiro Masakazu、Tanaka Masato、Sakai Ryuichi、Yamaguchi Hideki
    • Journal Title

      Cancer Letters

      Volume: 526 Pages: 335-345

    • DOI

      10.1016/j.canlet.2021.11.008

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07242, KAKENHI-PROJECT-21K07105, KAKENHI-PROJECT-20H03523, KAKENHI-PROJECT-20F20414, KAKENHI-PROJECT-20K07605
  • [Journal Article] Polycomb EZH1 regulates cell cycle/5‐fluorouracil sensitivity of neuroblastoma cells in concert with MYCN2022

    • Author(s)
      Shinno Yoshitaka、Takenobu Hisanori、Sugino Ryuichi P.、Endo Yuki、Okada Ryu、Haruta Masayuki、Satoh Shunpei、Mukae Kyosuke、Shaliman Dilibaerguli、Wada Tomoko、Akter Jesmin、Ando Kiyohiro、Nakazawa Atsuko、Yoshida Hideo、Ohira Miki、Hishiki Tomoro、Kamijo Takehiko
    • Journal Title

      Cancer Science

      Volume: 113 Issue: 12 Pages: 4193-4206

    • DOI

      10.1111/cas.15555

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08269, KAKENHI-PROJECT-22K15517, KAKENHI-PROJECT-20K08174, KAKENHI-PROJECT-19H03625
  • [Journal Article] Comparative epigenomics by machine learning approach for neuroblastoma2022

    • Author(s)
      Sugino Ryuichi P.、Ohira Miki、Mansai Sayaka P.、Kamijo Takehiko
    • Journal Title

      BMC Genomics

      Volume: 23 Issue: 1 Pages: 852-852

    • DOI

      10.1186/s12864-022-09061-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08269, KAKENHI-PROJECT-19H03625
  • [Journal Article] The PRC2 molecule EED is a target of epigenetic therapy for neuroblastoma2022

    • Author(s)
      Shaliman Dilibaerguli、Takenobu Hisanori、Sugino Ryuichi P.、Ohira Miki、Kamijo Takehiko
    • Journal Title

      European Journal of Cell Biology

      Volume: 101 Issue: 3 Pages: 151238-151238

    • DOI

      10.1016/j.ejcb.2022.151238

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08269, KAKENHI-PROJECT-20K08174, KAKENHI-PROJECT-19H03625
  • [Journal Article] SHP2 as a Potential Therapeutic Target in Diffuse-Type Gastric Carcinoma Addicted to Receptor Tyrosine Kinase Signaling2021

    • Author(s)
      Nagamura Yuko、Miyazaki Makoto、Nagano Yoshiko、Tomiyama Arata、Ohki Rieko、Yanagihara Kazuyoshi、Sakai Ryuichi、Yamaguchi Hideki
    • Journal Title

      Cancers

      Volume: 13 Issue: 17 Pages: 4309-4309

    • DOI

      10.3390/cancers13174309

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07242, KAKENHI-PROJECT-21K07105
  • [Journal Article] Loss of p53 suppresses replication stress-induced DNA damage in ATRX-deficient neuroblastoma2021

    • Author(s)
      Akter Jesmin、Katai Yutaka、Sultana Parvin、Takenobu Hisanori、Haruta Masayuki、Sugino Ryuichi P.、Mukae Kyosuke、Satoh Shunpei、Wada Tomoko、Ohira Miki、Ando Kiyohiro、Kamijo Takehiko
    • Journal Title

      Oncogenesis

      Volume: 10 Issue: 11 Pages: 1256-1256

    • DOI

      10.1038/s41389-021-00363-6

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15256, KAKENHI-PROJECT-19K16759, KAKENHI-PROJECT-20K07579, KAKENHI-PROJECT-20K08174, KAKENHI-PROJECT-20K08269, KAKENHI-PROJECT-19H03625
  • [Journal Article] PLEKHA5 regulates the survival and peritoneal dissemination of diffuse-type gastric carcinoma cells with Met gene amplification2021

    • Author(s)
      Nagamura Yuko、Miyazaki Makoto、Nagano Yoshiko、Yuki Masako、Fukami Kiyoko、Yanagihara Kazuyoshi、Sasaki Kazuki、Sakai Ryuichi、Yamaguchi Hideki
    • Journal Title

      Oncogenesis

      Volume: 10 Issue: 3 Pages: 25-25

    • DOI

      10.1038/s41389-021-00314-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07242, KAKENHI-PROJECT-18K07219, KAKENHI-PROJECT-19K16758, KAKENHI-PROJECT-21K06879, KAKENHI-PROJECT-16H06276
  • [Journal Article] Thymidylate synthase inhibitor raltitrexed can induce high levels of DNA damage in MYCN ‐amplified neuroblastoma cells2020

    • Author(s)
      Yamashita Ken、Kiyonari Shinichi、Tsubota Shoma、Kishida Satoshi、Sakai Ryuichi、Kadomatsu Kenji
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 7 Pages: 2431-2439

    • DOI

      10.1111/cas.14485

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07242, KAKENHI-PROJECT-19K07711, KAKENHI-PROJECT-19H03415
  • [Journal Article] Homophilic complex formation of CDCP1 via the extracellular CUB2 domain facilitates SFK activation and promotes cancer cell migration2019

    • Author(s)
      Sawayama Tadashi、Nakashima Katsuhiko、Ichimura Tohru、Sakai Ryuichi、Uekita Takamasa
    • Journal Title

      Oncology Reports

      Volume: 42 Pages: 1507-1516

    • DOI

      10.3892/or.2019.7271

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07242
  • [Journal Article] Combined Genetic and Chromosomal Characterization of Wilms Tumors Identifies Chromosome 12 Gain as a Potential New Marker Predicting a Favorable Outcome2019

    • Author(s)
      Haruta Masayuki、Arai Yasuhito、Okita Hajime、Tanaka Yukichi、Takimoto Tetsuya、Sugino Ryuichi P.、Yamada Yasuhiro、Kamijo Takehiko、Oue Takaharu、Fukuzawa Masahiro、Koshinaga Tsugumichi、Kaneko Yasuhiko
    • Journal Title

      Neoplasia

      Volume: 21 Issue: 1 Pages: 117-131

    • DOI

      10.1016/j.neo.2018.10.007

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01592, KAKENHI-PROJECT-16K08745, KAKENHI-PROJECT-16K10050, KAKENHI-PROJECT-17K19623, KAKENHI-PROJECT-19K08310, KAKENHI-PROJECT-17H04356, KAKENHI-PROJECT-19H03625
  • [Journal Article] Aberrant alternative splicing of RHOA is associated with loss of its expression and activity in diffuse-type gastric carcinoma cells2018

    • Author(s)
      Miyamoto Shingo、Nagamura Yuko、Nakabo Ayaka、Okabe Akira、Yanagihara Kazuyoshi、Fukami Kiyoko、Sakai Ryuichi、Yamaguchi Hideki
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 495 Issue: 2 Pages: 1942-1947

    • DOI

      10.1016/j.bbrc.2017.12.067

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K14616, KAKENHI-PROJECT-26290043, KAKENHI-PROJECT-16K14622, KAKENHI-PROJECT-18K07219, KAKENHI-PROJECT-17H04051
  • [Journal Article] Intracellular cholesterol level regulates sensitivity of glioblastoma cells against temozolomide-induced cell death by modulation of caspase-8 activation via death receptor 5-accumulation and activation in the plasma membrane lipid raft2018

    • Author(s)
      Yamamoto Yutaro、Tomiyama Arata、Sasaki Nobuyoshi、Yamaguchi Hideki、Shirakihara Takuya、Nakashima Katsuhiko、Kumagai Kosuke、Takeuchi Satoru、Toyooka Terushige、Otani Naoki、Wada Kojiro、Narita Yoshitaka、Ichimura Koichi、Sakai Ryuichi、Namba Hiroki、Mori Kentaro
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 495 Issue: 1 Pages: 1292-1299

    • DOI

      10.1016/j.bbrc.2017.11.113

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K14616, KAKENHI-PROJECT-26290043, KAKENHI-PROJECT-16K14622, KAKENHI-PROJECT-18K07219
  • [Journal Article] The p53 activator overcomes resistance to ALK inhibitors by regulating p53-target selectivity in ALK-driven neuroblastomas2018

    • Author(s)
      Miyazaki Makoto、Otomo Ryo、Matsushima-Hibiya Yuko、Suzuki Hidenobu、Nakajima Ayana、Abe Naomi、Tomiyama Arata、Ichimura Koichi、Matsuda Koichi、Watanabe Toshiki、Ochiya Takahiro、Nakagama Hitoshi、Sakai Ryuichi、Enari Masato
    • Journal Title

      Cell Death Discovery

      Volume: 4 Issue: 1 Pages: 1-17

    • DOI

      10.1038/s41420-018-0059-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07242, KAKENHI-PROJECT-16K14616
  • [Journal Article] The p53 activator overcomes resistance to ALK inhibitors by regulating p53-target selectivity in ALK-driven neuroblastomas2018

    • Author(s)
      Makoto Miyazaki, Ryo Otomo, Yuko Matsushima-Hibiya, Hidenobu Suzuki, Ayana Nakajima, Arata Tomiyama, Koichi Ichimura, Koichi Matsuda, Toshiki Watanabe, Takahiro Ochiya, Hitoshi Nakagama, Ryuichi Sakai, Yoichi Taya, and Masato Enari
    • Journal Title

      Cell Death Discovery

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26290043
  • [Journal Article] Actinin-1 and actinin-4 play essential but distinct roles in invadopodia formation by carcinoma cells2017

    • Author(s)
      Yamaguchi Hideki、Ito Yuumi、Miura Nami、Nagamura Yuko、Nakabo Ayaka、Fukami Kiyoko、Honda Kazufumi、Sakai Ryuichi
    • Journal Title

      European Journal of Cell Biology

      Volume: 96 Issue: 7 Pages: 685-694

    • DOI

      10.1016/j.ejcb.2017.07.005

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K14616, KAKENHI-PROJECT-26290043, KAKENHI-PROJECT-17H04051, KAKENHI-PROJECT-16K14622, KAKENHI-PROJECT-16H05547, KAKENHI-PROJECT-16K15833
  • [Journal Article] Novel small molecule inhibiting CDCP1-PKCδ pathway reduces tumor metastasis and proliferation.2017

    • Author(s)
      Nakashima K, Uekita T, Yano S, Kikuchi JI, Nakanishi R, Sakamoto N, Fukumoto K, Nomoto A, Kawamoto K, Shibahara T, Yamaguchi H, Sakai R.
    • Journal Title

      Cancer Sci.

      Volume: 印刷中 Issue: 5 Pages: 1049-1057

    • DOI

      10.1111/cas.13218

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26290043, KAKENHI-PROJECT-15K06850, KAKENHI-PROJECT-16K14616, KAKENHI-PROJECT-16K14622
  • [Journal Article] Report of the Japan diabetes society/Japanese cancer association joint committee on diabetes and cancer, Second report.2016

    • Author(s)
      Goto A, Noto H, Noda M, Ueki K, Kasuga M, Tajima N, Ohashi K, Sakai R, Tsugane S, Hamajima N, Tajima K, Imai K, Nakagama H.
    • Journal Title

      Cancer Science

      Volume: 107(3) Issue: 3 Pages: 369-71

    • DOI

      10.1111/cas.12889

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-26290043, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-16H06297
  • [Journal Article] Recurrent neomorphic mutations of MTOR in central nervous system and testicular germ cell tumors may be targeted for therapy2016

    • Author(s)
      Ichimura K, Fukushima S, Nagane M, The Intracranial Berm Cell Tumor Genome Analysis Consortium, et al
    • Journal Title

      Acta Neuropathol

      Volume: Published online: 08 March Issue: 6 Pages: 889-901

    • DOI

      10.1007/s00401-016-1557-x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25462277, KAKENHI-PROJECT-26290043, KAKENHI-PROJECT-15K10346, KAKENHI-PROJECT-15K10349, KAKENHI-PROJECT-15K15534
  • [Journal Article] Direct interaction between carcinoma cells and cancer associated fibroblasts for the regulation of cancer invasion2015

    • Author(s)
      Yamaguchi H, and Sakai R
    • Journal Title

      Cancers

      Volume: 7 Issue: 4 Pages: 2054-2062

    • DOI

      10.3390/cancers7040876

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25430126, KAKENHI-PROJECT-26290043
  • [Journal Article] Augmentation of invadopodia formation in temozolomide-resistant or adopted glioma is regulated by c-Jun terminal kinase-paxillin axis2015

    • Author(s)
      Ueno H, Tomiyama A, Yamaguchi H, Uekita T et al.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 468 Issue: 1-2 Pages: 240-247

    • DOI

      10.1016/j.bbrc.2015.10.122

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K06850, KAKENHI-PROJECT-25430126, KAKENHI-PROJECT-25461494, KAKENHI-PROJECT-26290043
  • [Journal Article] Saracatinib impairs the peritoneal dissemination of diffuse-type gastric carcinoma cells resistant to Met and fibroblast growth factor receptor inhibitors2014

    • Author(s)
      Yamaguchi H, Takanashi M, Yoshida N, Ito Y, Kamata R, Fukami K, Yanagihara K, Sakai R
    • Journal Title

      Cancer Sci

      Volume: 105 Pages: 528-536

    • Data Source
      KAKENHI-PROJECT-23300353
  • [Journal Article] Flotillin-1 regulates oncogenic signaling in neuroblastoma cells by regulating ALK membrane association2014

    • Author(s)
      Tomiyama A, Uekita T, Kamata R, Sasaki K, Takita J, Ohira M, Nakagawara A, Kitanaka C, Mori K, Yamaguchi H, Sakai R
    • Journal Title

      Cancer Res

      Volume: (in press)

    • Data Source
      KAKENHI-PROJECT-23300353
  • [Journal Article] Stromal fibroblasts mediate extracellular matrix remodeling and invasion of scirrhous gastric carcinoma cells.2014

    • Author(s)
      Yamaguchi H, Yoshida H, Takanashi M, Ito Y, Fukami K, Yanagihara K, Yashiro M, Sakai R.
    • Journal Title

      PlosOne

      Volume: 9 Issue: 1 Pages: e85485-e85485

    • DOI

      10.1371/journal.pone.0085485

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23300353, KAKENHI-PROJECT-23390329, KAKENHI-PROJECT-25430126, KAKENHI-PROJECT-26290043
  • [Journal Article] Flotillin-1 regulates oncogenic signaling in neuroblastoma cells by regulating ALK membrane association.2014

    • Author(s)
      Tomiyama A, Uekita T, Kamata R, Sasaki K, Takita J, Ohira M, Nakagawara A, Kitanaka C, Mori K, Yamaguchi H, Sakai R.
    • Journal Title

      Cancer Res.

      Volume: 74(14) Issue: 14 Pages: 3790-3801

    • DOI

      10.1158/0008-5472.can-14-0241

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24249061, KAKENHI-PROJECT-24501327, KAKENHI-PROJECT-25253095, KAKENHI-PROJECT-25430126, KAKENHI-PROJECT-25461402, KAKENHI-PROJECT-26290043, KAKENHI-PROJECT-26293242, KAKENHI-PROJECT-26461603, KAKENHI-PROJECT-26670493
  • [Journal Article] Flotillin-1 regulates oncogenic signaling in neuroblastoma cells by regulating ALK membrane association2014

    • Author(s)
      Tomiyama A, Uekita T, Kamata R, Sasaki K, Takita J, Ohira M, Nakagawara A, Kitanaka C, Mori K, Yamaguchi H, Sakai R
    • Journal Title

      Cancer Research

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Journal Article] Stromal fibroblasts mediate extracellular matrix remodeling and invasion of scirrhous gastric carcinoma cells2014

    • Author(s)
      Yamaguchi H, Yoshida N, Takanashi M, Ito Y, Fukami K, Yanagihara K, Yashiro M, Sakai R
    • Journal Title

      PLoS One

      Volume: 9

    • Data Source
      KAKENHI-PROJECT-23300353
  • [Journal Article] Oncogenic Ras/ERK signaling activates CDCP1 to promote tumor invasion and metastasis2014

    • Author(s)
      Uekita T, Fujii S et al.
    • Journal Title

      Molecular Cancer Research

      Volume: 12 Issue: 10 Pages: 1449-1459

    • DOI

      10.1158/1541-7786.mcr-13-0587

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24501327, KAKENHI-PROJECT-26290043
  • [Journal Article] Saracatinib impairs the peritoneal dissemination of diffuse-type gastric carcinoma cells resistant to Met and FGFR inhibitors.2014

    • Author(s)
      Yamaguchi H, Takanashi M, Yoshida N, Ito Y, Kamata R, Fukami K, Yanagihara K, Sakai R.
    • Journal Title

      Cancer Sci.

      Volume: 105 Issue: 5 Pages: 528-536

    • DOI

      10.1111/cas.12387

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23300353, KAKENHI-PROJECT-25430126, KAKENHI-PROJECT-26290043, KAKENHI-PROJECT-26293071
  • [Journal Article] CDCP1 regulates the function of MT1-MMP and invadopodia-mediated invasion of cancer cells2013

    • Author(s)
      Miyazawa Y, Uekita T, Ito Y, Seiki M, Yamaguchi H, Sakai R
    • Journal Title

      Mol Cancer Res

      Volume: 11 Pages: 628-637

    • Data Source
      KAKENHI-PROJECT-23300353
  • [Journal Article] Report of the Japan Diabetes Society/Japanese Cancer Association Joint Committee on Diabetes and Cancer2013

    • Author(s)
      Kasuga M, Ueki K, Tajima N, Noda M, Ohashi K, Noto H, Goto A, Ogawa W, Sakai R, Tsugane S, Hamajima N, Nakagama H, Tajima K, Miyazono K, Imai K
    • Journal Title

      Cancer Sci

      Volume: 104 Pages: 965-976

    • Data Source
      KAKENHI-PROJECT-23300353
  • [Journal Article] Suppression of autophagy by CUB domain-containing protein 1 signaling is essential for anchorage-independent survival of lung cancer cells.2013

    • Author(s)
      Uekita T, Fujii S, Miyazawa Y, Hashiguchi A, Abe H, Sakamoto M, Sakai R.
    • Journal Title

      Cancer Sci.

      Volume: 104 Issue: 7 Pages: 865-870

    • DOI

      10.1111/cas.12154

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23300353, KAKENHI-PROJECT-24501327, KAKENHI-PUBLICLY-23112524
  • [Journal Article] CDCP1 regulates the function of MT1-MMP and invadopodia-mediated invasion of cancer cells.2013

    • Author(s)
      Miyazawa Y, Uekita T, Ito Y, Seiki M, Yamaguchi H, Sakai R.
    • Journal Title

      Mol Cancer Res.

      Volume: 11(6) Issue: 6 Pages: 628-37

    • DOI

      10.1158/1541-7786.mcr-12-0544

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22220014, KAKENHI-PROJECT-23300353, KAKENHI-PROJECT-24501327, KAKENHI-PROJECT-25430126
  • [Journal Article] Suppression of autophagy by CUB domain-containing protein 1 signaling is essential for anchorage-independent survival of lung cancer cells2013

    • Author(s)
      Uekita T, Fujii S, Miyazawa Y, Hashiguchi A, Abe H, Sakamoto M, Sakai R
    • Journal Title

      Cancer Sci

      Volume: 104 Pages: 865-870

    • Data Source
      KAKENHI-PROJECT-23300353
  • [Journal Article] Identification of integrin α3 as a molecular marker of cells undergoing epithelial-mesenchymal transition and of cancer cells with aggressive phenotypes2013

    • Author(s)
      Shirakihara T, Kawasaki T, Fukagawa A, Semba K, Sakai R, Miyazono K, Miyazawa K, Saitoh M
    • Journal Title

      Cancer Sci

      Volume: 104 Pages: 1189-1197

    • Data Source
      KAKENHI-PROJECT-23300353
  • [Journal Article] Identification of integrin α3 as a molecular marker of cells undergoing epithelial-mesenchymal transition and of cancer cells with aggressive phenotypes.2013

    • Author(s)
      Shirakihara T, Kawasaki T, Fukagawa A, Semba K, Sakai R, Miyazono K, Miyazawa K, Saitoh M.
    • Journal Title

      Cancer Science

      Volume: 104 Issue: 9 Pages: 1189-1197

    • DOI

      10.1111/cas.12220

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22112002, KAKENHI-PROJECT-23300353, KAKENHI-PROJECT-24390419, KAKENHI-PROJECT-25830096
  • [Journal Article] Roles of CUB domain-containing protein 1 signaling in cancer invasion and metastasis2011

    • Author(s)
      Uekita T. and Sakai R
    • Journal Title

      Cancer Sci

      Volume: 102 Issue: 11 Pages: 1943-1948

    • DOI

      10.1111/j.1349-7006.2011.02052.x

    • NAID

      10030244592

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590350, KAKENHI-PUBLICLY-23112524, KAKENHI-PROJECT-23300353
  • [Journal Article] ARAP3 inhibits peritoneal dissemination of scirrhous gastric carcinoma cells by regulating cell adhesion and invasion2011

    • Author(s)
      Yagi R., Tanaka M., et al.
    • Journal Title

      Oncogene

      Volume: 30 Issue: 12 Pages: 1413-1421

    • DOI

      10.1038/onc.2010.522

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22300324, KAKENHI-PUBLICLY-23112524, KAKENHI-PROJECT-23650590
  • [Journal Article] Cancer susceptibility polymorphism of p53 at codon 72 affects phosphorylation and degradation of p53 protein2011

    • Author(s)
      Ozeki C, Sawai y Shibata T, Kohno T, Okamoto K, Yokota J, Tashiro F, Tanuma S, Sakai R, Kawase T, Kitabayashi I, Taya Y, Ohki R
    • Journal Title

      J Biol Chem.

      Volume: 286 Pages: 18251-18260

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-23112524
  • [Journal Article] Cancer susceptibility polymorphism of p53 at codon 72 affects phosphorylation and degradation of p53 protein2011

    • Author(s)
      Ozeki C, Sawai Y, Shibata T, Kohno T, Okamoto K, Yokota J, Tashiro F, Tanuma S, Sakai R, Kawase T, Kitabayashi I, Taya Y & Ohki R
    • Journal Title

      J Biol Chem

      Volume: 286 Pages: 18251-18260

    • Data Source
      KAKENHI-PROJECT-23300353
  • [Journal Article] Phosphoinositide 3-kinase signaling pathway mediated by p110α regulates invadopodia formation2011

    • Author(s)
      Yamaguchi H, Yoshida S, Muroi E, Yoshida N, Kawamura M, Kouchi Z, Nakamura Y, Sakai R, and Fukami K
    • Journal Title

      J. Cell Biol

      Volume: 193 Pages: 1275-1288

    • Data Source
      KAKENHI-PROJECT-23300353
  • [Journal Article] Roles of CUB domain-containing protein 1 signaling in cancer invasion and metastasis2011

    • Author(s)
      Uekita T & Sakai R
    • Journal Title

      Cancer Sci

      Volume: 12 Pages: 1943-1948

    • Data Source
      KAKENHI-PROJECT-23300353
  • [Journal Article] Cancer susceptibility polymorphism of p53 at codon 72 affects phosphorylation and degradation of p53 protein2011

    • Author(s)
      Ozeki C, Sawai Y, Shibata T, Kohno T, Okamoto K, Yokota J, Tashiro F, Tanuma S, Sakai R, Kawase T, Kitabayashi I, Taya Y, Ohki R
    • Journal Title

      J Biol Chem.

      Volume: 286 Pages: 18251-18260

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Journal Article] Phosphoinositide 3-kinase signaling pathway mediated by p110α regulates invadopodia formation2011

    • Author(s)
      Yamaguchi H, Yoshida S, Muroi E, Yoshida N, Kawamura M, Kouchi Z, Nakamura Y, Sakai R, Fukami K
    • Journal Title

      J.Cell Biol.

      Volume: 193 Issue: 7 Pages: 1275-1288

    • DOI

      10.1083/jcb.201009126

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-23112524, KAKENHI-PUBLICLY-23113729, KAKENHI-PROJECT-23300353, KAKENHI-PROJECT-23701069
  • [Journal Article] ARAP3 inhibits peritoneal dissemination of scirrhous gastric carcinoma cells by regulating cell adhesion and invasion2011

    • Author(s)
      Yagi R, Tanaka M, Sasaki K, Kamata R, Nakanishi Y, Kanai Y & Sakai R
    • Journal Title

      Oncogene

      Volume: 30 Pages: 1413-1421

    • Data Source
      KAKENHI-PROJECT-23300353
  • [Journal Article] 足場非依存性と転移能に関わるチロシンリン酸化蛋白質CDCP12010

    • Author(s)
      堺隆一
    • Journal Title

      医学のあゆみ 第232巻

      Pages: 934-935

    • Data Source
      KAKENHI-PROJECT-17014086
  • [Journal Article] A novel RNA-binding protein, Ossa/C9orf10 regulates activity of Src kinases to protect cells from oxidative stress-induced apoptosis.2009

    • Author(s)
      Tanaka, M., Sasaki, K., Kamata, R., Hoshino, Y., Yanagihara, K., Sakai, R.
    • Journal Title

      Mol. Cell. Biol. 2009 29

      Pages: 402-413

    • Data Source
      KAKENHI-PROJECT-17014086
  • [Journal Article] CUB-domain containing protein 1 regulates peritoneal dissemination of gastric scirrhous carcinoma.2008

    • Author(s)
      Uekita, T., Tanaka, M., Takigahira, M., Miyazawa, Y., Nakanishi, Y., Kanai, Y., Yanagihara, K., Sakai, R.
    • Journal Title

      Am. J. Pathol. 172

      Pages: 1729-1739

    • Data Source
      KAKENHI-PROJECT-17014086
  • [Journal Article] Hyperphosphorylated cortactin in cancer cells plays an inhibitory role in cell motility by regulating tyrosine phosphorylation of p130Cas.2008

    • Author(s)
      Jia, L., Uekita, T., Sakai, R.
    • Journal Title

      Mol. Cancer. Res. 6

      Pages: 654-662

    • Data Source
      KAKENHI-PROJECT-17014086
  • [Journal Article] Carboxyl terminus of ephrin-B1 regulates metalloproteinase secretion and invasion of cancer cells.2007

    • Author(s)
      Tanaka, M., Sasaki, K., Kamata, R., Sakai, R.
    • Journal Title

      J. Cell Sci. 120

      Pages: 2179-2189

    • Data Source
      KAKENHI-PROJECT-17014086
  • [Journal Article] Phosphorylation of ephrin-B1 regulates dissemination of gastric scirrhous carcinoma.2007

    • Author(s)
      Tanaka, M., Kamata, R., Takigahira, M., Yanagihara, K., Sakai, R.
    • Journal Title

      Am. J. Pathol. 171

      Pages: 68-78

    • Data Source
      KAKENHI-PROJECT-17014086
  • [Journal Article] CUB domain-containing protein 1 is a novel regulator of anoikis resistance in lung adenocarcinoma2007

    • Author(s)
      Uekita, T., Jia, L., Narisawa-Saito, M., Yokota, J., Kiyono, T., Sakai, R.
    • Journal Title

      Mol. Cell. Biol. 27

      Pages: 7649-7660

    • Data Source
      KAKENHI-PROJECT-17014086
  • [Journal Article] Force sensing by mechanical extension of the Src family kinase substrate p130Cas.2006

    • Author(s)
      Sawada, Y., Tamada, M., Dubrin-Thaler, B., Cherniavskaya, O., Sakai, R., Tanaka S., Sheetz M.P.
    • Journal Title

      Cell 127

      Pages: 1015-1026

    • NAID

      130005448723

    • Data Source
      KAKENHI-PROJECT-17014086
  • [Journal Article] Phosphorylation of ephrin-B1 via the interaction with claudin following cell-cell contract formation.2005

    • Author(s)
      Tanaka, M., Kamata, R., Sakai, R.
    • Journal Title

      EMBO J. 24

      Pages: 3700-3711

    • Data Source
      KAKENHI-PROJECT-17014086
  • [Presentation] A pioneer factor CDX1 modifies developmental pathway in neuroblastoma cells2021

    • Author(s)
      Hisanori Takenobu、 Ryuichi Sugino、Masayuki Hruta、Miki Ohira, Takehiko Kamijo
    • Organizer
      The 80th Annual Meeting of the Japanese Cancer Association
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03625
  • [Presentation] Development of a chondroblastic osteosarcoma model from iPSC-based neural crest cells2021

    • Author(s)
      Kyosuke Mukae1, Hisanori Takenobu1, Hiroaki Kanda2, Miki Ohira1, Yuki Endo1, Masayuki Haruta1, Ryuichi Sugino1, Shunpei Satoh1, Junya Toguchida3, 4, Kenji Osafune4, Tatsutoshi Nakahata4, Takehiko Kamijo1
    • Organizer
      The 80th Annual Meeting of the Japanese Cancer Association
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03625
  • [Presentation] PRC1.1 targets a potential tumor suppressor gene BTG2 in neuroblastoma2021

    • Author(s)
      Shunpei Satoh, Mariko Hasegawa, Ryuichi Sugino, Masayuki Hruta, Miki Ohira, Takehiko Kamijo
    • Organizer
      The 80th Annual Meeting of the Japanese Cancer Association
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03625
  • [Presentation] 神経芽腫における分化関連遺伝子のエピジェネティックな発現抑制メカニズムの解明2020

    • Author(s)
      Hisanori Takenobu, Zhenghao Li, Ryuichi P. Sugino, Kyosuke Mukae, Miki Ohira, Masayuki Haruta, Yuki Endo, Ryu Okada, Dilibaerguli Shaliman, Takehiko Kamijo
    • Organizer
      2020 エピジェネティック研究会
    • Data Source
      KAKENHI-PROJECT-19H03625
  • [Presentation] Identification and functional analysis of FGFR2 binding proteins in diffuse-type gastric carcinoma2019

    • Author(s)
      Shirakihara T, Sakai R
    • Organizer
      AACR Annual Meeting 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07242
  • [Presentation] スキルス胃がんの進展に関わるFGF受容体結合タンパク質TfR1の機能解析2019

    • Author(s)
      白木原琢哉、堺隆一
    • Organizer
      第28回日本がん転移学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-18K07242
  • [Presentation] Identification and functional analysis of FGFR2 binding proteins in schirrous gastric cancer2019

    • Author(s)
      Shirakihara T, Sakai R
    • Organizer
      11th AACR-JCA Joint Conference : Breakthrough in Cancer Research
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07242
  • [Presentation] スキルス胃癌と間質線維芽細胞の直接的相互作用に関わる分子の探索2019

    • Author(s)
      宮本真吾、宮崎允、柳原五吉、矢代正和、堺隆一、山口英樹
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K07242
  • [Presentation] Identification and functional analysis of FGFR2 binding proteins in diffuse-type gastric carcinoma2019

    • Author(s)
      Shirakihara T, Sakai R
    • Organizer
      AACR Annual Meeting 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K14616
  • [Presentation] びまん性胃がんの進展に関わるFGFR2結合タンパク質の探索と機能解析2019

    • Author(s)
      白木原琢哉、堺隆一
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K07242
  • [Presentation] Identification and functional analysis of FGFR2 binding proteins in schirrous gastric cancer2019

    • Author(s)
      Shirakihara T, Sakai R
    • Organizer
      11th AACR-JCA Joint Conference : Breakthrough in Cancer Research
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K14616
  • [Presentation] スキルス胃がんの進展に寄与するFGF受容体結合タンパク質の探索と機能解析2018

    • Author(s)
      白木原琢哉、堺隆一
    • Organizer
      第27回日本がん転移学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-16K14616
  • [Presentation] スキルス胃がんと間質線維芽細胞の直接的な相互作用に関わる分子機構の解明2018

    • Author(s)
      宮本真吾、堺隆一、山口英樹
    • Organizer
      第27回日本がん転移学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-16K14616
  • [Presentation] スキルス胃がんの進展に寄与するFGF受容体結合タンパク質の探索と機能解析2018

    • Author(s)
      白木原琢哉、堺隆一
    • Organizer
      第27回日本がん転移学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-18K07242
  • [Presentation] スキルス胃がんと間質線維芽細胞の直接的な相互作用に関わる分子機構の解明2018

    • Author(s)
      宮本真吾、堺隆一、山口英樹
    • Organizer
      第27回日本がん転移学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-18K07242
  • [Presentation] スキルス胃がんの進展に関わるFGFR2結合タンパク質の探索と機能解析2018

    • Author(s)
      白木原琢哉、堺隆一
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16K14616
  • [Presentation] びまん性胃がんにおけるRhoAのスプライシング異常とそれに伴う発現及び活性の低下2018

    • Author(s)
      宮本真吾、中坊彩花、深見希代子、柳原五吉、堺隆一、山口英樹
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16K14616
  • [Presentation] スキルス胃がんの進展に関わるFGFR2結合タンパク質の探索と機能解析2018

    • Author(s)
      白木原琢哉、堺隆一
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K07242
  • [Presentation] びまん性胃がんにおけるRhoAのスプライシング異常とそれに伴う発現及び活性の低下2018

    • Author(s)
      宮本真吾、中坊彩花、深見希代子、柳原五吉、堺隆一、山口英樹
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K07242
  • [Presentation] The signaling complex of tyrosine phosphstase SHP2 and docking protein ShcC regulates oncogenicity of neuroblastoma cells in a tyrosine-phosphorylation dependent manner2017

    • Author(s)
      Arata Tomiyama and Ryuichi Sakai
    • Organizer
      The 3rd Asia-Pacific International Symposium of Neuroblastoma
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290043
  • [Presentation] スキルス胃癌細胞におけるSHP2の機能解析2017

    • Author(s)
      山口英樹、富山新太、堺隆一
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-26290043
  • [Presentation] スキルス胃がんの悪性化に関わる受容体チロシンキナーゼ標的タンパク質の探索と機能解析2017

    • Author(s)
      白木原琢哉、堺隆一
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16K14616
  • [Presentation] スキルス胃癌細胞におけるSHP2の機能解析2017

    • Author(s)
      山口英樹、富山新太、堺隆一
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16K14616
  • [Presentation] スキルス胃癌細胞の増殖及び浸潤転移におけるSHP2の機能解析2017

    • Author(s)
      山口英樹、堺隆一
    • Organizer
      第26回日本がん転移学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-16K14616
  • [Presentation] 神経芽腫におけるALK受容体シグナルのFlotillin-1とShcC-Shp2経路による制御2016

    • Author(s)
      堺隆一、富山新太
    • Organizer
      第7回日本プロテインホスファターゼ研究会学術集会
    • Place of Presentation
      自然科学研究機構山手地区(愛知県岡崎市)
    • Year and Date
      2016-01-29
    • Data Source
      KAKENHI-PROJECT-26290043
  • [Presentation] 神経芽腫におけるShcCを介したSHP2とALKの結合は、神経芽腫細胞の腫瘍原性を制御する2016

    • Author(s)
      Arata Tomiyama, Takuya Shirakihara, Katsuhiko Nakashima, Hideki Yamaguchi, Kentaro Mori, Ryuichi Sakai
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-26290043
  • [Presentation] スキルス胃がんにおける活性化受容体型チロシンキナーゼ結合蛋白質の同定と機能解析2016

    • Author(s)
      白木原琢哉、山口英樹、堺隆一
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-16K14616
  • [Presentation] Interaction of SHP2 with ALK regulates oncogenicity of neuroblastoma cells2016

    • Author(s)
      Ryuichi Sakai
    • Organizer
      12th International Conference on Protein Phosphatase
    • Place of Presentation
      近畿大学(大阪府東大阪市)
    • Year and Date
      2016-10-27
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290043
  • [Presentation] Interaction between carcinoma cells and stromal fibroblasts during invasion and metastasis of scirrhous gastric carcinoma2016

    • Author(s)
      山口英樹、柳原五吉、八代正和、堺隆一
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-16K14616
  • [Presentation] The signaling complex of tyrosine phosphatase SHP2 and docking protein ShcC regulates oncogenicity of neuroblastoma cells in a tyrosine-phosphorylation dependent manner.2016

    • Author(s)
      Arata Tomiyama, Ryuichi Sakai
    • Organizer
      Advances in Neuroblastoma Research 2016
    • Place of Presentation
      Cairns, Australia
    • Year and Date
      2016-06-19
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290043
  • [Presentation] スキルス胃がんにおける新規チロシンリン酸化タンパク質PLEKHA5の機能解析2016

    • Author(s)
      山口英樹、白木原琢哉、堺隆一
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-16K14616
  • [Presentation] スキルス胃がん細胞におけるPLEKHA5の機能解析2016

    • Author(s)
      山口英樹、白木原琢哉、堺隆一
    • Organizer
      第25回日本がん転移学会学術集会・総会
    • Place of Presentation
      米子コンベンションセンター(鳥取県米子市)
    • Year and Date
      2016-07-21
    • Data Source
      KAKENHI-PROJECT-16K14616
  • [Presentation] 神経芽腫細胞におけるSHP2とALKの結合は、神経芽腫の腫瘍原性を制御する2015

    • Author(s)
      富山新太、上野英明、白木原琢哉、中島克彦、山口英樹、森健太郎、堺隆一
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-10
    • Data Source
      KAKENHI-PROJECT-26290043
  • [Presentation] Identification of ALK-binding phosphotyrosine-containing proteins as the critical regulators of oncogenic properties of neuroblastoma cells2015

    • Author(s)
      富山新太、堺隆一
    • Organizer
      2015 Asia-Pacific Symposium of Neuroblasoma
    • Place of Presentation
      台北(台湾)
    • Year and Date
      2015-11-14
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26290043
  • [Presentation] 神経芽腫のALK阻害剤感受性を制御するALK結合リン酸化蛋白質群2015

    • Author(s)
      堺隆一、富山新太
    • Organizer
      第38回日本分子生物学会年会第88回日本生化学大会・合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-26290043
  • [Presentation] Oncogenic Ras-ERK signaling requires activation of CDCP1 pathway for promotion of tumor metastasis2013

    • Author(s)
      Uekita T, Sakai R
    • Organizer
      9th AACR-Japanese Cancer Association Joint Conference
    • Place of Presentation
      Hawaii, USA
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] FGF-2 accelerates TGF-beta-induced epithelial-mesenchymal transition and promotes invasion of cancer2013

    • Author(s)
      Shirakihara T, Sakai R, Saitoh M
    • Organizer
      7th Mechanisms & Models of Cancer
    • Place of Presentation
      La Jolla, USA
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] Oncogenic Ras-ERK signaling requires activation of CDCP1 pathway for promotion of tumor metastasis2013

    • Author(s)
      堺 隆一
    • Organizer
      9th AACR-JCA Joint Conference
    • Place of Presentation
      Maui, USA
    • Year and Date
      2013-02-23
    • Data Source
      KAKENHI-PUBLICLY-23112524
  • [Presentation] Differential sensitivities to molecular target drugs in scirrhous gastric carcinoma cell lines2013

    • Author(s)
      Yamaguchi H, Yoshida N, Takanashi M, Yanagihara K, Sakai R
    • Organizer
      9th AACR-Japanese Cancer Association Joint Conference
    • Place of Presentation
      Hawaii, USA
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] 間質線維芽細胞との相互作用を指標としたスキルス胃癌腹膜播種に対する分子標的薬の探索2013

    • Author(s)
      山口英樹, 柳原五吉, 八代正和, 堺隆一
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] FGF-2 による TGF-β誘導性 EMT の亢進とがん浸潤への関与2013

    • Author(s)
      白木原琢哉, 齋藤正夫, 堺隆一
    • Organizer
      第22回日本がん転移学会学術集会・総会
    • Place of Presentation
      松本
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] がん細胞の足場非依存性増殖における CDCP1 シグナルを介したオートファジー抑制の重要性2013

    • Author(s)
      上北尚正, 堺隆一
    • Organizer
      第22回日本がん転移学会学術集会・総会
    • Place of Presentation
      松本
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] FGF-2 による TGF-β誘導性 EMT の亢進とがん浸潤への関与2013

    • Author(s)
      白木原琢哉, 堺隆一, 齋藤正夫
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] スキルス胃癌のシグナル異常の解析2013

    • Author(s)
      堺隆一
    • Organizer
      第85回日本胃癌学会総会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] Flotillin-1 is a novel ALK binding protein which regulates ALK signaling through receptor endocytosis2013

    • Author(s)
      Sakai R, Tomiyama A, Uekita T, Yamaguchi H, Sasaki K, Takita J, Nakagawara A, Mori K
    • Organizer
      7th Mechanisms & Models of Cancer
    • Place of Presentation
      La Jolla, USA
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] 新規 ALK 結合蛋白質である Flotillin-1 は, endocytosis を介して ALK シグナルを制御する2013

    • Author(s)
      富山新太, 上北尚正, 山口英樹, 佐々木一樹, 滝田順子, 中川原章, 森健太郎, 堺隆一
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] CDCP1 はMT1-MMP の機能と浸潤突起を介した癌細胞の浸潤を制御する2013

    • Author(s)
      上北尚正, 山口英樹, 堺隆一
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] CDCP1 regulates the function of MT1-MMP and invadopodia-mediated invasion of cancer cells2013

    • Author(s)
      Uekita T, Yamaguchi H, Sakai R
    • Organizer
      7th Mechanisms & Models of Cancer
    • Place of Presentation
      La Jolla, USA
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] スキルス胃癌のシグナル異常の解析2013

    • Author(s)
      堺 隆一
    • Organizer
      第85回日本胃癌学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2013-02-01
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-23112524
  • [Presentation] 新規ALK 結合蛋白質であるFlotillin-1 は, endocytosisを介してALKシグナルを制御する2012

    • Author(s)
      富山新太, 上北尚正, 山口英樹, 鎌田礼子, 佐々木一樹, 中川原章, 堺隆一
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] Cancer-associated fibroblasts mediate extracellular matrix remodeling and three-dimensional invasion of scirrhous gastric carcinoma cells2012

    • Author(s)
      Yamaguchi H, Yanagihara K, Yashiro M, Sakai R
    • Organizer
      AACR Annual Meeting 2012
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2012-04-01
    • Data Source
      KAKENHI-PUBLICLY-23112524
  • [Presentation] スキルス胃癌細胞におけるMetシグナル伝達系の機能解析2012

    • Author(s)
      山口英樹, 堺隆一
    • Organizer
      第21回日本がん転移学会学術集会・総会
    • Place of Presentation
      広島
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] 神経芽腫におけるALKによるRETタンパク質発現制御の解析2012

    • Author(s)
      二見仁康, 堺隆一
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] CDCP1 links Ras and Src signaling pathways as a common effecter for the promotion of tumor metastasis2012

    • Author(s)
      堺 隆一
    • Organizer
      AACR Annual Meeting
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2012-04-02
    • Data Source
      KAKENHI-PUBLICLY-23112524
  • [Presentation] CDCP1 は Ras により発現誘導され. がん細胞の足場非依存性及び浸潤, 転移に関与する2012

    • Author(s)
      上北尚正, 堺隆一
    • Organizer
      第21回日本がん転移学会学術集会・総会
    • Place of Presentation
      広島
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] CDCP1 links Ras and Src signaling pathways as a common effecter for the promotion of tumor metastasis2012

    • Author(s)
      Sakai R, Uekita T
    • Organizer
      AACR Annual Meeting 2012
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2012-04-02
    • Data Source
      KAKENHI-PUBLICLY-23112524
  • [Presentation] CDCP1 links Ras and Src signaling pathways as a common effecter for the promotion of tumor metastasis2012

    • Author(s)
      Sakai R, Uekita T
    • Organizer
      AACR Annual Meeting 2012
    • Place of Presentation
      Chicago, USA
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] スキルス胃癌細胞株における c-Met 受容体型チロシンキナーゼ依存性の検討2012

    • Author(s)
      山口英樹, 柳原五吉, 堺隆一
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] Differential reqirements for the receptor tyrosine kinase c-Met in scirrhous gastric carcinoma cell lines2012

    • Author(s)
      Yoshida N, Yamaguchi H, Muroi E, Takanashi M, Fukami K, Sakai R
    • Organizer
      AACR Annual Meeting 2012
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2012-04-02
    • Data Source
      KAKENHI-PUBLICLY-23112524
  • [Presentation] Differential reqirements for the receptor tyrosine kinase c-Met in scirrhous gastric carcinoma cell lines2012

    • Author(s)
      Yoshida N, Yamaguchi H, Muroi E, Takanashi M, Fukami K, Sakai R
    • Organizer
      AACR Annual Meeting 2012
    • Place of Presentation
      Chicago, USA
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] Flotillin-1 is a novel ALK binding protein which regulates ALK signaling through receptor endocytosis2012

    • Author(s)
      Tomiyama A, Uekita T, Sakai R
    • Organizer
      Advances in Neuroblastoma Research 2012
    • Place of Presentation
      Toronto, Canada
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] Cancer-associated fibroblasts mediate extracellular matrix remodeling and three-dimensional invasion of scirrhous gastric carcinoma cells2012

    • Author(s)
      Yamaguchi H, Yanagihara K, Yashiro M, Sakai R
    • Organizer
      AACR Annual Meeting 2012
    • Place of Presentation
      Chicago, USA
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] Ras-ERK シグナルによる癌の転移能の亢進は CDCP1 発現誘導を介する2012

    • Author(s)
      上北尚正, 清野透, 堺隆一
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] 腫瘍由来線維芽細胞との共培養によるスキルス胃がん浸潤機構の解析2011

    • Author(s)
      山口英樹, 柳原五吉, 八代正和, 堺隆一
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] CDCP1 links RAS and Src signaling pathways as a common effector for the promotion of tumor metastasis2011

    • Author(s)
      Uekita T, Sakai R
    • Organizer
      Mechanisms & Models of Cancer 2011
    • Place of Presentation
      La Jolla, USA
    • Year and Date
      2011-08-13
    • Data Source
      KAKENHI-PUBLICLY-23112524
  • [Presentation] Critical role of CDCP1 in RAS-mediated tumor progression and cell death2011

    • Author(s)
      Sakai R
    • Organizer
      France-Japanese Symposium on Cancer Research
    • Place of Presentation
      Tokyo, Japan
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] スキルス胃がん細胞の胃癌由来線維芽細胞を介した細胞外基質リモテリングと浸潤2011

    • Author(s)
      山口英樹、堺隆一
    • Organizer
      第20回日本がん転移学会学術集会・総会
    • Place of Presentation
      浜松
    • Year and Date
      2011-08-14
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] スキルス胃がん細胞の胃癌由来線維芽細胞を介した細胞外基質リモデリングと浸潤2011

    • Author(s)
      山口英樹、堺隆一
    • Organizer
      第20回日本がん転移学会学術集会・総会
    • Place of Presentation
      浜松
    • Year and Date
      2011-08-14
    • Data Source
      KAKENHI-PUBLICLY-23112524
  • [Presentation] CDCP1 によるオートファジーの抑制はがん細胞の足場非依存性増殖に重要である2011

    • Author(s)
      上北尚正, 堺隆一
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] CDCP1 links RAS and Src signaling pathways as a common effector for the promotion of tumor metastasis2011

    • Author(s)
      Uekita T, Sakai R
    • Organizer
      Mechanisms & Models of Cancer 2011
    • Place of Presentation
      La Jolla, USA
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] CDCP1 links Ras and Src signaling pathways as a common effector for the promotion of tumor metastasis2011

    • Author(s)
      Uekita T, Miyazawa Y, Sakai R
    • Organizer
      Japanese-German Cancer Workshop
    • Place of Presentation
      Hiroshima, Japan
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] CDCP1 links Ras and Src signaling pathways as a common effector for the promotion of tumor metastasis2011

    • Author(s)
      Uekita T, Miyazawa Y, Sakai R
    • Organizer
      Japanese-German Cancer Workshop
    • Place of Presentation
      広島
    • Year and Date
      2011-09-18
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] 神経芽腫におけるALKのチロシンリン酸化結合体白質群の同定とALK特異的ながん化シグナルにおける役割2011

    • Author(s)
      富山新太、山口英樹、鎌田礼子、中川原章、北中千史、堺隆一
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] 腫瘍由来線維芽細胞との共培養によるスキルス胃がん浸潤機構の解析2011

    • Author(s)
      山口英樹、柳原五吉、八代正和、堺隆一
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
    • Data Source
      KAKENHI-PUBLICLY-23112524
  • [Presentation] 神経芽腫のALK標的治療におけるRETシグナルの関わり2011

    • Author(s)
      二見仁康, 堺隆一
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] Critical role of CDCP1 in RAS-mediated tumor progression and cell death2011

    • Author(s)
      Sakai R
    • Organizer
      France-Japanese Symposium on Cancer Research
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-11-02
    • Data Source
      KAKENHI-PUBLICLY-23112524
  • [Presentation] 神経芽腫のALK標的治療におけるRETシグナルの関わり2011

    • Author(s)
      二見仁康、堺隆一
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
    • Data Source
      KAKENHI-PUBLICLY-23112524
  • [Presentation] スキルス胃がん細胞の胃癌由来線維芽細胞を介した細胞外基質リモデリングと浸潤2011

    • Author(s)
      山口英樹, 堺隆一
    • Organizer
      第20回日本がん転移学会学術集会・総会
    • Place of Presentation
      浜松
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] 神経芽腫におけるALKのチロシンリン酸化結合体白質群の同定とALK特異的ながん化シグナルにおける役割2011

    • Author(s)
      富山新太、山口英樹、鎌田礼子、中川原章、北中千史、堺隆一
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
    • Data Source
      KAKENHI-PUBLICLY-23112524
  • [Presentation] CDCP1 links Ras and Src signaling pathways as a common effector for the promotion of tumor metastasis2011

    • Author(s)
      Uekita T, Miyazawa Y, Sakai R
    • Organizer
      Japanese-German Cancer Workshop
    • Place of Presentation
      広島
    • Year and Date
      2011-09-18
    • Data Source
      KAKENHI-PUBLICLY-23112524
  • [Presentation] Critical role of CDCP1 in RAS-mediated tumor progression and cell death2011

    • Author(s)
      Sakai R
    • Organizer
      France-Japanese Symposium on Cancer Research
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-11-02
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] 神経芽腫における ALK のチロシンリン酸化結合体白質群の同定と ALK特異的ながん化シグナルにおける役割2011

    • Author(s)
      富山新太, 山口英樹, 鎌田礼子, 中川原章, 北中千史, 堺隆一
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] CDCP1によるオートファジーの抑制はがん細胞の足場非依存性増殖に重要である2011

    • Author(s)
      上北尚正、堺隆一
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-05
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] CDCP1によるオートファジーの抑制はがん細胞の足場非依存性増殖に重要である2011

    • Author(s)
      上北尚正、堺隆一
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-05
    • Data Source
      KAKENHI-PUBLICLY-23112524
  • [Presentation] A novel phosphoprotein, Ossa/C9orf10 protects cancer cells from oxidative stress-induced apoptosis2010

    • Author(s)
      Sakai R.
    • Organizer
      Japanese-German Cancer Workshop, Hamburg
    • Place of Presentation
      Germany.
    • Data Source
      KAKENHI-PROJECT-17014086
  • [Presentation] A novel phosphoprotein, Ossa/C9orf10 protects cancer cells from oxidative stress-induced apoptosis2010

    • Author(s)
      Sakai R
    • Organizer
      The 8th Joint Conference of AACR and JCA
    • Place of Presentation
      Hawaii
    • Year and Date
      2010-02-08
    • Data Source
      KAKENHI-PROJECT-17014086
  • [Presentation] スキルス胃がんの酸化ストレス抵抗性に関わる分子Ossaの機能解析2009

    • Author(s)
      堺隆一、田中正光
    • Organizer
      第18回日本がん転移学会学術集会・総会
    • Place of Presentation
      旭川
    • Data Source
      KAKENHI-PROJECT-17014086
  • [Presentation] 癌の酸化ストレス抵抗性に関わる新規分子Ossaの機能解析2009

    • Author(s)
      堺隆一
    • Organizer
      第4回日本プロテインホスファターゼ研究会学術総会
    • Place of Presentation
      熊本
    • Year and Date
      2009-11-13
    • Data Source
      KAKENHI-PROJECT-17014086
  • [Presentation] Role of membrane protein, CDCP1 in tumor metastasis and invasion.2009

    • Author(s)
      Sakai R.
    • Organizer
      Japanese-German Cancer Workshop
    • Place of Presentation
      Hamburg
    • Year and Date
      2009-09-17
    • Data Source
      KAKENHI-PROJECT-17014086
  • [Presentation] Regulation of invasion and metastasis by a Src substrate, CDCP12009

    • Author(s)
      Sakai R.
    • Organizer
      2nd DKFZ-NCC Workshop on Cancer Research
    • Place of Presentation
      Tokyo
    • Year and Date
      2009-07-07
    • Data Source
      KAKENHI-PROJECT-17014086
  • [Presentation] 肺腺癌における新規レセプターCDCP1の発現意義2008

    • Author(s)
      森井英一、池田純一郎、上北尚正、堺隆一、青笹克之
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Data Source
      KAKENHI-PROJECT-17014086
  • [Presentation] スキルス型癌の間質浸潤におけるリン酸化蛋白質の解析.2008

    • Author(s)
      田中正光、鎌田礼子、佐々木一樹、堺隆一
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Data Source
      KAKENHI-PROJECT-17014086
  • [Presentation] がん細胞の足場非依存性増殖を制御するCDCP1の機能ドメインの解析2008

    • Author(s)
      上北尚正、堺隆一
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Data Source
      KAKENHI-PROJECT-17014086
  • [Presentation] Analysis of domain function of CDCP1 in anoikis resistance of cancer cells.2008

    • Author(s)
      Sakai R., Uekita T., Miyazawa Y.
    • Organizer
      Mechanisms & Models of Cancer Meeting
    • Place of Presentation
      Cold Spring Harbor, USA
    • Data Source
      KAKENHI-PROJECT-17014086
  • [Presentation] 肺癌細胞の足場非依存性と転移能を制御する新規蛋白質CDCP1の解析2008

    • Author(s)
      堺隆一
    • Organizer
      第17回日本がん転移学会学術集会・総会
    • Place of Presentation
      鹿児島
    • Data Source
      KAKENHI-PROJECT-17014086
  • [Presentation] CDCP1によるがん細胞の運動能・浸潤能制御機構の解析2008

    • Author(s)
      宮澤悠里、上北尚正、堺隆一
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Data Source
      KAKENHI-PROJECT-17014086
  • [Presentation] ShcC protein controls differentiation of neuroblastoma cells.2008

    • Author(s)
      Sakai R., Ohira, M., Nakagawara, A., Miyake, I..
    • Organizer
      Advances in Neuroblastoma Research 2008
    • Place of Presentation
      Chiba, Japan
    • Data Source
      KAKENHI-PROJECT-17014086
  • [Presentation] 乳癌細胞におけるエストロゲン受容体α/HDAC6複合体による新規nongenomic作用2008

    • Author(s)
      東浩太郎、浦野友彦、林慎一、堺隆一、大内尉義、井上聡
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Data Source
      KAKENHI-PROJECT-17014086
  • [Presentation] Roles of phosphotyrosine-containing molecules in tumor progression.2008

    • Author(s)
      Sakai R.
    • Organizer
      Kyoto Prize 2008 Memorial Workshop
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2008-11-12
    • Data Source
      KAKENHI-PROJECT-17014086
  • [Presentation] CDCP1 regulates metastatic potential of humancan cers through anoikis resistance2007

    • Author(s)
      Sakai R & Uekita T.
    • Organizer
      The 12th Korea-Japan Cancer Research Workshop
    • Place of Presentation
      札幌
    • Year and Date
      2007-12-21
    • Data Source
      KAKENHI-PROJECT-17014086
  • [Presentation] CDCP1 regulates anoikis resistance in human lung adenocarcinoma2007

    • Author(s)
      Sakai R, Uekita T.
    • Organizer
      Mechanisms & Models of Cancer Meeting
    • Place of Presentation
      San Diego, USA
    • Data Source
      KAKENHI-PROJECT-17014086
  • [Presentation] シグナルドッキング分子と癌2006

    • Author(s)
      堺隆一
    • Organizer
      第15回広島大学・広島がんセミナー学術講演会
    • Place of Presentation
      広島
    • Year and Date
      2006-02-23
    • Data Source
      KAKENHI-PROJECT-17014086
  • [Presentation] 神経細胞の分化増殖異常と癌2006

    • Author(s)
      堺隆一
    • Organizer
      第29回日本神経科学大会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-17014086
  • [Presentation] Analysis of domain functions of ShcC protein in neuroblastoma2006

    • Author(s)
      Sakai, R., Miyake, I.
    • Organizer
      12th conference of Advances in Neuroblastoma Research
    • Place of Presentation
      Los Angeles, USA
    • Data Source
      KAKENHI-PROJECT-17014086
  • [Presentation] Oncogenic Ras-ERK signaling requires activation of CDCP1 pathway for promotion of tumor metastasis

    • Author(s)
      堺 隆一
    • Organizer
      9th AACR-JCA Joint Conference
    • Place of Presentation
      Maui, USA
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] スキルス胃癌のシグナル異常の解析

    • Author(s)
      堺 隆一
    • Organizer
      第85回日本胃癌学会総会
    • Place of Presentation
      大阪
    • Invited
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] Regulation of oncogenic signaling in neuroblastoma through binding partners of anaplastic lymphoma kinase.

    • Author(s)
      Sakai R
    • Organizer
      第11回プロテインホスファターゼ国際カンファレンス
    • Place of Presentation
      仙台
    • Year and Date
      2014-11-12 – 2014-11-14
    • Data Source
      KAKENHI-PROJECT-26290043
  • [Presentation] CDCP1 links Ras and Src signaling pathways as a common effecter for the promotion of tumor metastasis

    • Author(s)
      堺 隆一
    • Organizer
      AACR Annual Meeting
    • Place of Presentation
      Chicago, USA
    • Data Source
      KAKENHI-PROJECT-23300353
  • [Presentation] 新規ALK結合蛋白質であるFlotillin-1は、ALKの細胞膜結合の調節を介してALKシグナルを制御する.

    • Author(s)
      富山新太,上北尚正,山口英樹,上野英明,滝田順子,佐々木一樹,中川原章,森健太郎,堺隆一
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-26290043
  • [Presentation] Flotillin-1 regulates oncogenic signaling in neuroblastoma cells through receptor endocytosis of anaplastic lymphoma kinase

    • Author(s)
      Tomiyama A,Uekita T,Sakai R
    • Organizer
      Advances in Neuroblastoma Research 2014
    • Place of Presentation
      ケルン、ドイツ
    • Year and Date
      2014-05-13 – 2014-05-16
    • Data Source
      KAKENHI-PROJECT-26290043
  • []

  • 1.  HONDA Hiroaki (40245064)
    # of Collaborated Projects: 12 results
    # of Collaborated Products: 0 results
  • 2.  MANO Hiroyuki (90240704)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 0 results
  • 3.  HIRAI Hisamaru (90181130)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 4.  SAITO Masaki (60012762)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 5.  OZAWA Keiya (30137707)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 6.  MATSUDA Kazuhiro (80251502)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 7.  HAMANAKA Yuichiro (40189618)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 8.  NISHIDA Junji (80228189)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 9.  ISHII Atsushi (20232225)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 10.  TANAKA Tomoyuki (50227154)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 11.  白木原 琢哉 (30548756)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 11 results
  • 12.  山口 英樹 (10345035)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 17 results
  • 13.  豊島 秀男
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  Kamijo Takehiko (90262708)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 15.  宮川 清 (40200133)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  三谷 絹子 (50251244)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  花園 豊 (70251246)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  薮中 宗之 (70240637)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  大田 雅嗣 (90160514)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  大平 美紀 (20311384)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  牛島 俊和 (90232818)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  Tomiyama Arata
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 11 results
  • 23.  Kurosawa Gene
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  TAKIMOTO Tetsuya
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  NAGANE Motoo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 26.  市川 美紀
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 9 results
  • 27.  上北 尚正
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 28.  田中 正光
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  中川原 章
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  清木 元治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  宮園 浩平
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  AKTER JESMIN
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 33.  野田 哲生
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 34.  今井 浩三
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 35.  津金 昌一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 36.  甲斐 正広
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 37.  浜嶋 信之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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